STAT3 - signal transducer and activator of transcription 3 Gene

Species: Macaca mulatta

Gene Type: protein coding
Gene ID: 574128

About STAT3

Primary_assembly 16: 53,440,779-53,524,629 reverse strand.Mmul_10:CM014351.1

This gene has 3 transcripts (splice variants), 133 orthologues and 6 paralogues.

STAT3 Products (13)

mRNA Protein Name
XM_028836496.1 XP_028692329.1 signal transducer and activator of transcription 3 isoform X6
XM_028836497.1 XP_028692330.1 signal transducer and activator of transcription 3 isoform X7
XM_028836498.1 XP_028692331.1 signal transducer and activator of transcription 3 isoform X8
XM_028836501.1 XP_028692334.1 signal transducer and activator of transcription 3 isoform X11
XM_028836500.1 XP_028692333.1 signal transducer and activator of transcription 3 isoform X10
XM_028836492.1 XP_028692325.1 signal transducer and activator of transcription 3 isoform X2
XM_028836502.1 XP_028692335.1 signal transducer and activator of transcription 3 isoform X12
XM_028836493.1 XP_028692326.1 signal transducer and activator of transcription 3 isoform X3
XM_028836491.1 XP_028692324.1 signal transducer and activator of transcription 3 isoform X1
XM_028836495.1 XP_028692328.1 signal transducer and activator of transcription 3 isoform X5
XM_028836494.1 XP_028692327.1 signal transducer and activator of transcription 3 isoform X4
XM_028836503.1 XP_028692336.1 signal transducer and activator of transcription 3 isoform X13
XM_028836499.1 XP_028692332.1 signal transducer and activator of transcription 3 isoform X9

STAT3 Protein Structure

STAT_int

STAT_int: smart00964 (96 - 214)

STAT3_CCD

STAT3_CCD: cd16853 (233 - 421)

STAT3_DBD

STAT3_DBD: cd16847 (424 - 587)

SH2_STAT3

SH2_STAT3: cd10374 (657 - 818)

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  • 800
  • 874 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib Inhibitor 99.85% Yes
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown
HY-N0193 Artesunate Inhibitor 99.89% Yes
HY-14944 Homoharringtonine Inhibitor 99.96% Yes
HY-B0497 Niclosamide Inhibitor 99.96% Yes
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-B2163 Astaxanthin Inhibitor 98.0% Unkown
HY-12987 Pimozide Inhibitor 99.94% Yes
HY-10201A Sorafenib tosylate Inhibitor 99.98% Yes
HY-B0130 Perindopril 99.85% Yes
HY-17015A Peramivir 99.94% Unkown
HY-B1436 Nifuroxazide Inhibitor 99.90% Unkown
HY-B0294 Flubendazole Inhibitor 99.05% Yes
HY-15728 Radotinib Inhibitor 99.19% Yes
HY-B0130A Perindopril erbumine 99.98% Yes
HY-B0667 Balsalazide Inhibitor 98.65% Yes
HY-B0667A Balsalazide sodium hydrate Inhibitor 98.30% Yes
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-112961 Patiromer Inhibitor 95.0% Unkown
HY-B0497B Niclosamide monohydrate Inhibitor / Unkown
HY-100754A Ritlecitinib malonate Inhibitor / Unkown
HY-108244 Balsalazide disodium Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9916 Sarilumab Inhibitor 99.36% Unkown
HY-P99118 Serplulimab Inducer 99.30% Unkown

Clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-12987S Pimozide-d4 Inhibitor 99.2% Phase 4
HY-16141 Cilengitide Inhibitor 99.91% Phase 3
HY-13919 Napabucasin Inhibitor 99.94% Phase 3
HY-113066C Guanosine 5'-diphosphate sodium, 96% (HPLC) Inhibitor 99.88% Phase 3
HY-109038 Mocravimod Activator 98.39% Phase 3
HY-113066 Guanosine 5'-diphosphate Inhibitor / Phase 3
HY-112288 C188-9 Inhibitor 99.84% Phase 2
HY-15312 WP1066 Inhibitor 99.53% Phase 2
HY-136657 SC-43 Inhibitor 99.01% Phase 2
HY-14743B Golotimod hydrochloride Inhibitor 99.79% Phase 2
HY-14743 Golotimod Inhibitor 98.98% Phase 2
HY-14743A Golotimod TFA Inhibitor / Phase 2
HY-156730 KT-333 Degrader 98.91% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-16196 ENMD-1198 Inhibitor 98.87% Phase 1
HY-156730A KT-333 ammonium Degrader 99.48% Phase 1
HY-156730B KT-333 diammonium Degrader / Phase 1
HY-124067 EC-70124 Inhibitor / Phase 1
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99210 Olokizumab Inhibitor 99.54% Phase 3
HY-P99244 Fezakinumab Modulator 99.9% Phase 2
HY-P991888 INCA033989 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (227)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13818 Stattic Inhibitor 99.96% Unkown
HY-107632 GYY4137 Inhibitor 98.64% Unkown
HY-12000 AG490 Inhibitor 99.86% Unkown
HY-P1061 Colivelin Activator 99.92% Unkown
HY-10074 TPCA-1 Inhibitor 99.66% Unkown
HY-15146 NSC 74859 Inhibitor 98.35% Unkown
HY-N0751 Scutellarin Inhibitor 99.57% Unkown
HY-N0174 Cryptotanshinone Inhibitor 99.07% Unkown
HY-148748 Butyzamide Activator 99.83% Unkown
HY-129602 SD-36 Inhibitor 99.73% Unkown
HY-N0177 Diosgenin Inhibitor 99.92% Unkown
HY-N0250 Saikosaponin D Inhibitor 99.81% Unkown
HY-125771 1-Stearoyl-sn-glycero-3-phosphocholine Inhibitor 99.53% Unkown
HY-P1061A Colivelin TFA Activator 99.79% Unkown
HY-111152 ML115 Agonist 99.98% Unkown
HY-N0622 Morusin Inhibitor 99.54% Unkown
HY-129603 SI-109 Inhibitor 99.91% Unkown
HY-16975 SH-4-54 Inhibitor 99.80% Unkown
HY-N1405 Cucurbitacin I Inhibitor 99.60% Unkown
HY-100493 BP-1-102 Inhibitor 99.26% Unkown
HY-100753 STAT3-IN-1 Inhibitor 96.28% Unkown
HY-115594 Erasin Inhibitor 96.02% Unkown
HY-N0038 Alantolactone Inhibitor 99.94% Unkown
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-N0202 Atractylenolide II Inhibitor 99.89% Unkown
HY-170621 STAT1/3-IN-1 Inhibitor 99.23% Unkown
HY-128588 STAT3-IN-3 Inhibitor 98.40% Unkown
HY-N2959 Brevilin A Inhibitor 99.86% Unkown
HY-N0826 Corynoline Modulator 98.84% Unkown
HY-113205 15-keto-Prostaglandin E2 Inhibitor ≥99.0% Unkown
HY-19536 LLL12 Inhibitor 99.45% Unkown
HY-160496 STAT3-IN-25 Inhibitor 99.36% Unkown
HY-103692 STX-0119 Inhibitor 98.40% Unkown
HY-100602 HJC0152 Inhibitor 99.75% Unkown
HY-121983 CAY10594 Inhibitor 98.64% Unkown
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-100453 HO-3867 Inhibitor 99.67% Unkown
HY-N6954 Garcinone C Inhibitor 99.51% Unkown
HY-N2312 Mogrol Inhibitor 99.76% Unkown
HY-N2116 Ginkgolic acid C17:1 Inhibitor 99.80% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-122258 NSC-370284 Inhibitor 99.27% Unkown
HY-N2963 Broussonin E Activator 98.11% Unkown
HY-148692 OSM-SMI-10B Inhibitor 99.70% Unkown
HY-N0735 Phellodendrine chloride Inhibitor 99.68% Unkown
HY-113573 Protosappanin A 99.95% Unkown
HY-N6953 Garcinone D Activator 99.30% Unkown
HY-103128 inS3-54A18 Inhibitor 99.93% Unkown
HY-N0897 Corylifol A Inhibitor 99.90% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-129125 YMU1 Activator 99.19% Unkown
HY-N2521 Tetramethylcurcumin Inhibitor 99.91% Unkown
HY-158142 PROTAC TYK2 degrader-1 Inhibitor 99.55% Unkown
HY-N6711 Equisetin Inhibitor 99.40% Unkown
HY-N1356 Reticuline Inhibitor 98.89% Unkown
HY-150538 STAT3-IN-12 Inhibitor 99.87% Unkown
HY-P10201A Ac-GpYLPQTV-NH2 acetate Inhibitor 99.00% Unkown
HY-N0918 Desmethoxyyangonin Inhibitor 99.00% Unkown
HY-P10953 Fulipiftide Activator 99.38% Unkown
HY-12538 Graveoline Inhibitor 99.93% Unkown
HY-164546 WB436B Inhibitor 99.93% Unkown
HY-129138 Cyanidin 3,5-diglucoside chloride Inhibitor 99.44% Unkown
HY-N1410 Triacetylresveratrol Inhibitor 99.11% Unkown
HY-18061 Ochromycinone Inhibitor 99.61% Unkown
HY-12352A HJC0416 hydrochloride Inhibitor 98.68% Unkown
HY-156466 QL-1200186 Inhibitor 99.95% Unkown
HY-N9561 Vanicoside B Inhibitor 99.82% Unkown
HY-151976 STAT3-IN-15 Inhibitor 98.99% Unkown
HY-N1988 Cucurbitacin IIa Activator 99.90% Unkown
HY-P5314 OK2 Inhibitor 99.13% Unkown
HY-N7064 Iminostilbene Inhibitor 99.34% Unkown
HY-136658 STAT3-IN-48 Inhibitor 98.64% Unkown
HY-N7695 Physalin B Inhibitor 97.20% Unkown
HY-124858 SC99 Inhibitor 98.90% Unkown
HY-N3239 Mulberrofuran G Inhibitor 97.86% Unkown
HY-N1407 Polygalaxanthone III Activator 99.28% Unkown
HY-148706 STAT3-IN-17 Inhibitor 98.0% Unkown
HY-124686 ER-464195-01 Inhibitor 99.72% Unkown
HY-179715 PROTAC JAK1/2 degrader-1 Inhibitor 99.47% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-163526 STAT3-IN-26 96.84% Unkown
HY-163176 WB518 Inhibitor 96.48% Unkown
HY-120395 UC-514321 Inhibitor 98.0% Unkown
HY-125771S 1-Stearoyl-sn-glycero-3-phosphocholine-d35 Inhibitor 99% Unkown
HY-N0143A Phlorizin dihydrate Antagonist 99.51% Unkown
HY-P2282 APTSTAT3-9R Inhibitor 98.82% Unkown
HY-147187 MNK8 Inhibitor 99.76% Unkown
HY-163502 PROTAC STAT3 degrader-3 Degrader 99.75% Unkown
HY-N2000 Bellidifolin Modulator 99.74% Unkown
HY-122949 Momordicine I Inhibitor 97.0% Unkown
HY-100494 SH5-07 Inhibitor 98.0% Unkown
HY-125170 Galiellalactone Inhibitor 99% Unkown
HY-N0427 Phellodendrine Inhibitor 99.60% Unkown
HY-172946 SD-2301 Degrader / Unkown
HY-100610 S3I-1757 Inhibitor 99.51% Unkown
HY-112391 SD-1029 Inhibitor 88.8% Unkown
HY-120692 Cyclanoline chloride Inhibitor 96.27% Unkown
HY-113509B 15(R)-Lipoxin A4 Inhibitor 98.3% Unkown
HY-N8389 Globulol Inhibitor 99.74% Unkown
HY-N2240 Eupalinolide K Inhibitor 99.20% Unkown
HY-169908 STAT3-IN-37 Inhibitor / Unkown
HY-172767 STAT3-D11-PROTAC-VHL Degrader 96.33% Unkown
HY-125542 DCZ3301 Inhibitor 99.73% Unkown
HY-150251 SD-91 Degrader 97.49% Unkown
HY-117511 HJC0123 Inhibitor 99.06% Unkown
HY-N6651 Isocryptotanshinone Inhibitor ≥98.0% Unkown
HY-177990 STAT3-IN-52 Inhibitor / Unkown
HY-178821 ROCK2-IN-12 Inhibitor 98.02% Unkown
HY-P10201 Ac-GpYLPQTV-NH2 Inhibitor 99.38% Unkown
HY-107595 SD-1008 Inhibitor 99.10% Unkown
HY-182359 YYSW001 Inhibitor / Unkown
HY-144871 STAT3-IN-8 Inhibitor / Unkown
HY-176876 Glucocorticoid receptor/IL-6-IN-1 Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-182380 ODZ10117 Inhibitor / Unkown
HY-174988 JAK2-IN-13 Inhibitor / Unkown
HY-169403 NW16 Inhibitor / Unkown
HY-162885 YSY01A Inhibitor / Unkown
HY-175634 ALOX5 stabilizer-1 Inhibitor / Unkown
HY-159157 Anti-inflammatory agent 92 Inhibitor / Unkown
HY-180117 MMP-2/9-IN-2 Inhibitor / Unkown
HY-N3913 Furowanin A Inhibitor / Unkown
HY-175320 PROTAC c-Met degrader-5 Inhibitor / Unkown
HY-N13352 Bufothionine Inhibitor / Unkown
HY-122759 CPA-7 Inhibitor / Unkown
HY-175227 STAT3/NF-κB-IN-1 Inhibitor / Unkown
HY-180956 PROTAC ALK degrader-5 Inhibitor / Unkown
HY-W717425 SC-60 Inhibitor / Unkown
HY-175201 pro-FTY Inhibitor / Unkown
HY-161864 STAT3-IN-29 Inhibitor / Unkown
HY-175781 CHI3L1-IN-4 Inhibitor / Unkown
HY-165386 TU-100 Inhibitor / Unkown
HY-184162 HSP110-IN-1 Inhibitor / Unkown
HY-181514 STAT3-IN-53 Inhibitor / Unkown
HY-183272 PI3K/Akt/mTOR-IN-7 Inhibitor / Unkown
HY-150895 SI-191 Ligand / Unkown
HY-12352 HJC0416 Inhibitor / Unkown
HY-180795 PKM2 activator 11 Inhibitor / Unkown
HY-169797 STAT3-IN-38 Inhibitor / Unkown
HY-146666 STAT3-IN-9 Inhibitor / Unkown
HY-180937 CHI3L1-IN-6 Inhibitor / Unkown
HY-138071 8α-Tigloyloxyhirsutinolide 13-O-acetate Inhibitor 95.0% Unkown
HY-N11501 7-epi-Isogarcinol Inhibitor / Unkown
HY-12292G IM-12 (GMP) Inhibitor / Unkown
HY-183783 PROTAC RET Degrader 2 Inhibitor / Unkown
HY-149700 ROCK2-IN-7 / Unkown
HY-125718 MLS-2384 free base / Unkown
HY-176555 Z169667518 Inhibitor / Unkown
HY-182288 YN11 Inhibitor / Unkown
HY-164216A (trans)-STAT6-IN-13 Modulator / Unkown
HY-182922 SD-965 Degrader / Unkown
HY-181587 PDGFRA/CAIX/XII-IN-1 Inhibitor 98.10% Unkown
HY-120031 NSC-368262 Inhibitor / Unkown
HY-175848 NSC 850745 Inhibitor / Unkown
HY-184149 ROCK2-IN-17 / Unkown
HY-174428 PROTAC JAK2 degrader-1 Inhibitor / Unkown
HY-175010 STAT3-IN-44 Inhibitor / Unkown
HY-161859 VEGFR-2/STAT-3-IN-1 Inhibitor / Unkown
HY-161351 STAT3/AKT-IN-1 Inhibitor / Unkown
HY-180226 Apoptosis inducer 55 Inhibitor / Unkown
HY-131559 N-Deacetyl-SI-109-(OEt)2 / Unkown
HY-175009 MRC-G-001 Inhibitor / Unkown
HY-184119 Pabgraminone C Modulator / Unkown
HY-164216 STAT6-IN-13 Inhibitor / Unkown
HY-181872 JAK1-IN-20 Inhibitor / Unkown
HY-183307 mTOR-IN-29 / Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-162803 c-Met-IN-24 Inhibitor / Unkown
HY-101021 Ascochlorin Inhibitor / Unkown
HY-N17494 Crispene E Inhibitor / Unkown
HY-183628 MEAP Modulator / Unkown
HY-168178 Hsp110-STAT3 PPI-IN-2 Inhibitor / Unkown
HY-183370 JAK2/STAT3-IN-2 Inhibitor / Unkown
HY-180245 STAT3-IN-51 Inhibitor / Unkown
HY-170947 Antitumor agent-195 Inhibitor / Unkown
HY-176535 KB-0118 Inhibitor / Unkown
HY-129341 WP1193 Inhibitor / Unkown
HY-164445 STAT3-IN-32 Inhibitor / Unkown
HY-181783 CHI3L1-IN-7 Inhibitor / Unkown
HY-115541 BRD4-IN-41 / Unkown
HY-183143 Lss-11 Inhibitor / Unkown
HY-153023 PROTAC STAT3 degrader-2 Degrader / Unkown
HY-182273 DM243 Modulator / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-N13294 Cernuumolide J Inhibitor / Unkown
HY-182510 NTZ-24 Inhibitor / Unkown
HY-146728 STAT3-IN-10 Inhibitor / Unkown
HY-170977 JAK1/STAT3-IN-1 Inhibitor / Unkown
HY-112447 STAT3-IN-5 Inhibitor / Unkown
HY-175013 CDK6/9-IN-2 Inhibitor / Unkown
HY-180922 EGFR kinase-IN-8 Inhibitor / Unkown
HY-174457 STAT3/CAIX-IN-1 Inhibitor / Unkown
HY-181773 P-gp-IN-36 Inhibitor / Unkown
HY-169370 STAT3 HiBiT degrader 1 Degrader / Unkown
HY-183670 JAK2-IN-21 Inhibitor / Unkown
HY-175298 STAT-3/c-Src-IN-1 Inhibitor / Unkown
HY-153858 PHI-501 Inhibitor / Unkown
HY-N16557 (Rac)-8-Gingerol Inhibitor / Unkown
HY-N13338 Avicin D Inhibitor / Unkown
HY-164533 STAT3-IN-33 Inhibitor / Unkown
HY-182274 DM245 Inhibitor / Unkown
HY-170946 WR-S-462 Inhibitor / Unkown
HY-149257 HAT-SIL-TG-1&AT Inhibitor / Unkown
HY-179468 STAT3-IN-49 Inhibitor / Unkown
HY-115438 AUH-6-96 Inhibitor / Unkown
HY-178140 STAT3-IN-47 Inhibitor / Unkown
HY-174386 STAT3-IN-43 Inhibitor / Unkown
HY-168903 STAT3-IN-41 Inhibitor / Unkown
HY-175771 STAT3-IN-46 Inhibitor / Unkown
HY-179243 S3D5 Degrader / Unkown
HY-N0390G L-Glutamine (GMP) Inhibitor / Unkown
HY-171038 STAT3-IN-39 Inhibitor / Unkown
HY-N14323 Madindoline A Inhibitor / Unkown
HY-164521 PMMB-187 Inhibitor / Unkown
HY-119009 TM-233 Inhibitor / Unkown
HY-N4189 Isocucurbitacin B Inhibitor 98.98% Unkown
HY-N16435 Plumericin Inhibitor / Unkown
HY-N20636 7α-Morroniside Inhibitor / Unkown
HY-107632G GYY4137 (GMP) Inhibitor / Unkown
HY-164425 ENT-03 Activator / Unkown
HY-N8098 Pulchinenoside E2 Inhibitor 99.28% Unkown
HY-183519 AH057 / Unkown
HY-N15201 Betavulgarin Inhibitor / Unkown
HY-124595 MPT0B098 / Unkown
HY-164473 DETD-35 Inhibitor / Unkown
HY-169361 STAT3 ligand 5 / Unkown
HY-N18989 Cyclo(L-Ile-D-Leu) Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99143 Anti-Mouse NK1.1 Antibody (PK136) Inhibitor 98.57% Unkown
HY-P991218 Anti-IL11 Antibody (X203) Inhibitor 98.53% Unkown
HY-P990212 Anti-Mouse IL-6 Antibody (MP5-20F3) Inhibitor 99.36% Unkown
HY-P990279 Anti-Mouse CD276/B7-H3 Antibody (MJ18) Inhibitor 95.00% Unkown
HY-P990294 Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Inhibitor 95.00% Unkown
HY-P99917 Eflepedocokin alfa Activator ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens STAT3 NCBI NCBI:6774