C3 - complement C3 Gene

Also Known as ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 718

About C3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,677,704-6,720,650 (from NCBI)

This gene has 28 transcripts (splice variants), 268 orthologues, 8 paralogues and is associated with 6 phenotypes. Biased expression in liver (RPKM 1676.7), gall bladder (RPKM 250.0) and 5 other tissues.

Summary

Complement component C3 plays a central role in the activation of Complement System. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

C3 Products (2)

mRNA Protein Name
NM_000064.4 NP_000055.2 complement C3 preproprotein
NM_000064.4 NP_000055.2 complement C3 preproprotein
Molecular Function GO Annotation Evidence Verweise Source
enables C5L2 anaphylatoxin chemotactic receptor binding IDA
IDA: Inferred from direct assay
15833747 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7483825 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
21527715 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in B cell activation IDA
IDA: Inferred from direct assay
30107486 GOA
involved in complement activation IMP
IMP: Inferred from mutant phenotype
19302245 GOA
involved in positive regulation of D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
9059512 GOA
involved in positive regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15833747 GOA
involved in positive regulation of apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
19302245 GOA
involved in positive regulation of lipid storage IDA
IDA: Inferred from direct assay
9555951 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15833747 GOA
involved in positive regulation of vascular endothelial growth factor production IDA
IDA: Inferred from direct assay
16452172 GOA
involved in regulation of triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
10432298 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
25645918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C3 Protein Structure

A2M_N

A2M_N: MG2 domain (129 - 224)

A2M_N_2

A2M_N_2: Alpha-2-macroglobulin family N-terminal region (456 - 605)

ANATO

ANATO: Anaphylotoxin-like domain (693 - 728)

A2M

A2M: Alpha-2-macroglobulin family (770 - 866)

Thiol-ester_cl

Thiol-ester_cl: Alpha-macro-globulin thiol-ester bond-forming region (1000 - 1029)

A2M_comp

A2M_comp: A-macroglobulin complement component (1051 - 1283)

A2M_recep

A2M_recep: A-macroglobulin receptor (1398 - 1493)

NTR

NTR: UNC-6/NTR/C345C module (1534 - 1644)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1663 a.a.
Protein Preferred Names Protein Names

complement C3

  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1

C3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
C3 P01024 KRTAP10-8 Homo sapiens P60410 32296183
Intra
C3 P01024 KRTAP10-8 Homo sapiens P60410 32296183
Intra
C3 P01024 KRTAP10-8 Homo sapiens P60410 32296183
Intra
C3 P01024 CFH Homo sapiens P08603
SPR
21317894
Intra
C3 P01024 CFH Homo sapiens P08603 21979047
Intra
C3 P01024 CFH Homo sapiens P08603 21317894
Intra
C3 P01024 CFH Homo sapiens P08603 21317894
Intra
C3 P01024 CFH Homo sapiens P08603
NMR
21317894
Intra
C3 P01024 CFHR4 Homo sapiens Q92496-1 22518841
Intra
C3 P01024 Q03591-PRO_0000005896 Homo sapiens Q03591-PRO_0000005896 27814381
Intra
C3 P01024 CD46 Homo sapiens P15529 23086448
Intra
C3 P01024 CD46 Homo sapiens P15529 18796626
Intra
C3 P01024 CR2 Homo sapiens P20023
SPR
21527715
Intra
C3 P01024 CR2 Homo sapiens P20023 11387479
Intra
C3 P01024 CR2 Homo sapiens P20023 21527715
Intra
C3 P01024 CR2 Homo sapiens P20023 11387479
Intra
C3 P01024 GOLGA6L9 Homo sapiens A6NEM1 32296183
Intra
C3 P01024 GOLGA6L9 Homo sapiens A6NEM1 32296183
Intra
C3 P01024 AGR2 Homo sapiens O95994 32296183
Intra
C3 P01024 AGR2 Homo sapiens O95994 32296183
Intra
C3 P01024 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
C3 P01024 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
C3 P01024 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
C3 P01024 EFEMP2 Homo sapiens O95967 32296183
Intra
C3 P01024 EFEMP2 Homo sapiens O95967 32296183
Intra
C3 P01024 VSIG4 Homo sapiens Q9Y279-1
SPR
16530040
Intra
C3 P01024 VSIG4 Homo sapiens Q9Y279-1 16530040
Intra
C3 P01024 VSIG4 Homo sapiens Q9Y279-1 16530040
Intra
C3 P01024 VSIG4 Homo sapiens Q9Y279-2
SPR
16530040
Intra
C3 P01024 VSIG4 Homo sapiens Q9Y279-2 16530040
Intra
C3 P01024 KRT31 Homo sapiens Q15323 32296183
Intra
C3 P01024 KRT31 Homo sapiens Q15323 32296183
Intra
C3 P01024 KRT31 Homo sapiens Q15323 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C3 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7862 Complement C3a Protein, Human P01024 (S672-R748) ≥ 95%, as determined by reducing SDS-PAGE.

C3 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P80577 C3 Antibody (YA575) WB, IHC-P Human
HY-P80577A C3 Antibody (YA575)(PBS only) WB, IHC-P Human
HY-P83897 C3C Antibody (YA3594) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P83897A C3C Antibody (YA3594)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Hemolytic Uremic Syndrome, Atypical 5
  • AHUS5

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5

  • Atypical Hemolytic-Uremic Syndrome With C3 Anomaly

  • Ahus 5

  • Ahus, Susceptibility To, 5

  • Hemolytic Uremic Syndrome Atypical 5

  • Atypical Hemolytic Uremic Syndrome With C3 Anomaly

Complement Component 3 Deficiency, Autosomal Recessive
  • C3 Deficiency

  • C3D

  • C3 Deficiency, Autosomal Recessive

  • Complement Component 3 Deficiency

  • C3 Deficiency Autosomal Recessive

  • Complement Component 3 Deficiency Autosomal Recessive

  • Immune System Diseases

Macular Degeneration, Age-Related, 9
  • Age Related Macular Degeneration 9

  • ARMD9

  • Macular Degeneration, Age-Related, 9, Susceptibility To

  • Macular Degeneration, Age-Related, Type 9

Complement Component 3 Deficiency
  • C3 Deficiency

Atypical Hemolytic Uremic Syndrome With Complement Gene Abnormality
  • Atypical Hus With Complement Gene Abnormality

  • Ahus With Complement Gene Abnormality

D-Minus Hemolytic Uremic Syndrome
  • Atypical Hus

  • Atypical Hemolytic Uremic Syndrome

  • Hus, Atypical

  • Ahus

Hemolytic Uremic Syndrome, Atypical 1
  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical

Membranoproliferative Glomerulonephritis
  • Mesangiocapillary Glomerulonephritis

  • Dense Deposit Disease

  • Membranoproliferative Glomerulonephritis Type 2

  • Primary Membranoproliferative Glomerulonephritis

  • Mesangiocapillary Glomerulonephritis, Type Ii

  • Glomerulonephritis, Membranoproliferative

  • Chronic Glomerulonephritis, Lobular

  • Lobular Glomerulonephritis

  • Ddd

  • Glomerulonephritis Membranoproliferative Type 2

  • Mpgn 2

  • Membranoproliferative Glomerulonephritis Type Ii

  • Mesangiocapillary Glomerulonephritis Type 2

  • Mpgn

  • Primary Mpgn

  • Glomerulonephritis Membranoproliferative

  • Membranoproliferative Glomerulonephritis, Type Ii

Genetic Atypical Hemolytic-Uremic Syndrome
  • Familial Atypical Hemolytic-Uremic Syndrome

  • Familial Atypical Hemolytic Uremic Syndrome

Hemolytic-Uremic Syndrome
  • Hemolytic Uremic Syndrome

  • Haemolytic-Uraemic Syndrome

  • Hus

  • Acute Renal Failure, Thrombocytopenia, And Microangiopathic Hemolytic Anemia Associated With Distorted Erythrocytes

  • Typical Haemolytic Uraemic Syndrome

  • Gasser Syndrome

  • Hus - [Haemolytic Uraemic Syndrome]

Glomerulonephritis
  • Bright'S Disease

Arteriolosclerosis
Complement Deficiency
  • Complement Deficiency Disease

  • Hereditary Complement Deficiency Diseases

Retinal Drusen
Hemoglobinuria
Diffuse Glomerulonephritis
  • Glomerulonephritis Diffuse

Afibrinogenemia, Congenital
  • Congenital Afibrinogenemia

  • Afibrinogenemia

  • Factor I Deficiency

  • Familial Afibrinogenemia

  • Hypofibrinogenemia, Congenital

  • Fibrinogen Deficiency

  • Afibrinogenemia Congenital

  • CAFBN

  • Congenital Hypofibrinogenemia

  • Hypofibrinogenemia

  • Complement Factor I Deficiency

Histoplasmosis
  • Darling Disease

  • Reticuloendotheliosis, X-Linked

  • Infection By Histoplasma Capsulatum

  • Histoplasma Infection

  • Reticuloendothelial Cytomycosis

  • Cytomycosis

  • Darling Histoplasmosis

  • African Histoplasmosis

  • Histoplasmosis Duboisii

Hemolytic Anemia
  • Anemia, Hemolytic

  • Anemia Hemolytic

  • Anaemia Due To Other Disorders Of Glutathione Metabolism

  • Chronic Non Spherocytic Anaemia

  • G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

  • Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

  • Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

  • Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

  • Favism Anaemia

  • Haemolytic Anaemia Due Tog6pd Deficiency

  • Favism

  • Pentose Phosphate Pathway Disorder Anaemia

  • Anaemia Due To Pentose Phosphate Pathway Defect

Louse-Borne Relapsing Fever
  • Relapsing Fever, Louse-Borne

  • Relapsing Fever Due To Borrelia Recurrentis

Capillary Leak Syndrome
  • Systemic Capillary Leak Syndrome

  • Clarkson Disease

  • Capillary Leak Syndrome With Monoclonal Gammopathy

  • Scls

  • Periodic Systemic Capillary Leak Syndrome

  • Capillary Hyperpermeability Syndrome

  • Idiopathic Capillary Leak Syndrome

Exudative Glomerulonephritis
Middle Ear Cholesterol Granuloma
  • Cholesterin Granuloma

  • Cholesterin Granuloma Of Middle Ear

Erythema Nodosum
Neuromyelitis Optica
  • Devic Disease

  • Devic Syndrome

  • Neuromyelitis Optica Spectrum Disorder

  • Devic'S Disease

  • Devic'S Syndrome

  • Devic'S Neuromyelitis Optica

  • Nmo

  • Nmo Spectrum Disorder

  • Neuromyelitis Optica Spectrum Disorders

  • Devic Neuromyelitis Optica

  • Optic-Spinal Ms

  • Opticospinal Ms

  • Nmosd

  • Opticospinal Multiple Sclerosis

  • Devic

  • Ophthalmoneuromyelitis

  • Optic Neuromyelitis

  • Optic Neuroencephalomyelopathy

  • Nmo - [Neuromyelitis Optica]

  • Optic Neuritis With Demyelination

Complement Factor I Deficiency
  • Complement Component 3 Inactivator Deficiency

  • C3 Inactivator Deficiency

  • Hereditary Factor I Deficiency Disease

  • C3 Glomerulopathy 2

  • CFID

  • C3g2

  • Immunodeficiency With Factor I Anomaly

  • Complete Factor I Deficiency

  • CFI DEFICIENCY

  • Deficiency, Complement Factor I

  • Complement Factor I Deficiency

  • Deficiency Of Factor 1

  • Hereditary Fibrinogen Deficiency

  • Deficiency Of Fibrinogen

  • Congenital Fibrinogenopenia

C3 Glomerulopathy
  • C3 Glomerulonephritis

  • C3g

  • Non-Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis

  • Glomerulonephritis With Dominant C3

  • Ddd

  • Ddd/Mpgnii

  • Dense Deposit Disease

  • Membranoproliferative Glomerulonephritis Type Ii

  • Non-Ig-Mediated Mpgn

  • Non-Ig-Mediated Membranoproliferative Glomerulonephritis

  • Non-Immunoglobulin-Mediated Mpgn

  • Membranoproliferative Glomerulonephritis, Type Ii

Hypersensitivity Reaction Type Iii Disease
  • Immune Complex Diseases

  • Immune Complex Disease

  • Type Iii Hypersensitivity Reaction Disease

Eye Disease
  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy

Lyme Disease
  • Lyme Borreliosis

  • Lyme Neuroborreliosis

  • Borreliosis

  • Borrelia Burgdorferi Infection

  • Neuroborreliosis

  • Bannwarth Syndrome

  • Bannworth'S Syndrome

  • Neurological Lyme Disease

  • B. Burgdorferi Infection

  • Borreliosis, Lyme

  • Infection By Borrelia Burgdorferi

  • Infection Due To Borrelia Burgdorferi Sensu Lato

  • Lym

  • Borrelia Infections

Herpes Simplex
  • Herpes Simplex Infections

  • Herpesvirus Hominis Disease

  • Herpes Simplex Disease

  • Herpesviral Infection Due To Herpes Simplex

  • Infections Due To Simplex Virus

  • Herpes Nos

Pulmonary Tuberculosis
  • Tuberculosis, Pulmonary

  • PTB

  • Tuberculosis Pulmonary

Vasculitis
  • Angiitis

  • Autoimmune Vasculitis

  • Systemic Vasculitis

  • Vasculitis, Autoimmune

Epidermolysis Bullosa Dystrophica, Autosomal Dominant
  • Epidermolysis Bullosa Dystrophica, Cockayne-Touraine Type

  • Epidermolysis Bullosa Dystrophica, Pasini Type

  • Epidermolysis Bullosa Dystrophica, Ad

  • Autosomal Dominant Dystrophic Epidermolysis Bullosa

  • Generalized Dominant Dystrophic Epidermolysis Bullosa

  • DDEB

  • Dystrophic Epidermolysis Bullosa, Autosomal Dominant

  • Ebdct

  • Albopapuloid Dominant Dystrophic Epidermolysis Bullosa

  • Ebdd

  • Dominant Dystrophic Epidermolysis Bullosa

  • Autosomal Dominant Dystrophic Epidermolysis Bullosa, Pasini And Cockayne-Touraine Types

  • Ddeb, Pasini And Cockayne-Touraine Types

  • Ddeb, Generalized

  • Ddeb-Gen

  • Dominant Dystrophic Epidermolysis Bullosa, Generalized

  • Autosomal Dominant Generalized Dystrophic Epidermolysis Bullosa

  • Generalized Ddeb

  • Epidermolysis Bullosa Dystrophica, With Subcorneal Cleavage

  • EBDSC

  • Cockayne-Touraine Disease

  • Epidermolysis Bullosa Dystrophica With Subcorneal Cleavage

Acute Diffuse Nephritis
  • Acute Diffuse Glomerulonephritis

Antiphospholipid Syndrome
  • Antiphospholipid Antibody Syndrome

  • Hughes Syndrome

  • Familial Antiphospholipid Syndrome

  • Aps

  • Lupus Anticoagulant, Familial

  • Anti-Phospholipid Syndrome

  • Apls

  • Classic Apls

  • Classic Antiphospholipid Syndrome

  • Acromegaloid Facial Appearance Syndrome

  • Anticardiolipin Syndrome

Hyperlipidemia, Familial Combined, 3
  • Familial Combined Hyperlipidemia

  • Combined Hyperlipidemia, Familial

  • Mixed Hyperlipidaemia

  • FCHL3

  • Hyperlipidemia, Familial Combined

  • Familial Multiple Lipoprotein-Type Hyperlipidemia

  • Hyperbetalipoproteinemia With Prebetalipoproteinemia

  • Type Iib Hyperlipoproteinemia

  • Hyperlipidemia Familial Combined

  • Hyperlipoproteinemia Type Iib

  • Mixed Hyperlipemia

  • Hyperlipidaemia, Group C

  • Familial Hypercholesterolaemia With Hyperlipaemia

  • Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

  • Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

  • Hypercholesterolaemia With Endogenous Hyperglyceridaemia

  • Prebetalipoproteinemia Hyperbetalipoproteinaemia

  • Remnant Hyperlipoproteinemia

End Stage Renal Disease
  • End Stage Renal Failure

  • End-Stage Kidney Disease

  • Kidney Failure, Chronic

  • Chronic Kidney Disease Stage 5

Complement Component 5 Deficiency
  • C5 Deficiency

  • C5D

Meningococcal Infection
  • Meningococcal Disease

  • Meningococcal Infections

  • Neisseria Meningitidis Infection

  • Meningococcal Diseases

  • Meningococcus

  • Infection Due To Neisseria Meningitidis

  • Meningococcal Disease Nos

  • Meningococcal Infection Nos

Acute Poststreptococcal Glomerulonephritis
  • Post-Streptococcal Glomerulonephritis

  • Acute Post-Streptococcal Glomerulonephritis

Purpura
  • Purpuric Disorder

Meningitis
  • Streptococcal Meningitis

  • Acute Streptococcal Meningitis

  • Staphylococcal Meningitis

  • Adenoviral Meningitis

  • Influenza Meningitis

  • Influenzal Meningitis

  • Meningitis Due To H. Influenzae

  • Cryptococcal Meningitis

  • Fungal Meningitis Due To Cryptococcus Neoformans

  • Cryptococcosis Meningitis

  • Cryptococcus Meningitis

  • Cryptococcal Meningoencephalitis

  • Meningitis Due To Cryptococcus

  • Mumps Virus Meningitis

  • Mumps Meningitis

Macular Degeneration, Age-Related, 1
  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2

Angioedema
  • Angioneurotic Oedema

  • Quincke'S Edema

  • Angioneurotic Edema

  • Giant Urticaria

Heart Disease
  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure

Lupus Erythematosus
  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]

Otitis Media
  • Opsoclonus-Myoclonus Syndrome

  • OMS

  • Otitis Media, Susceptibility To

  • Kinsbourne Syndrome

  • Otitis Media, Chronic/Recurrent

  • Come/Rom

  • Ataxo-Opso-Myoclonus Syndrome

  • Dancing Eye Syndrome

  • Dancing Eye-Dancing Feet Syndrome

  • Oma Syndrome

  • Opsoclonus Myoclonus Syndrome

  • Opsoclonus-Myoclonus-Ataxia Syndrome

  • Poma Syndrome

  • Paraneoplastic Opsoclonus-Myoclonus

  • Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome

  • Opsoclonus Myoclonus

  • OM

  • {Otitis Media, Susceptibility To}

  • Infectious Otitis Media

Systemic Lupus Erythematosus
  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]

Pyuria
  • Pus Cells In Urine

Degeneration Of Macula And Posterior Pole
  • Degeneration Of Macula And Posterior Pole Of Retina

  • Degeneration Of Macula Or Posterior Pole

  • Macular Degeneration Nos

  • Degenerative Disorder Of Macula

  • Drusen Macular Degeneration

  • Posterior Pole Macular Degeneration Of Eye

  • Macular Eye Degeneration

  • Macular Degeneration Of Retina, Unspecified

  • Pseudohole Degeneration Of Macula Of Retina

Acute Proliferative Glomerulonephritis
  • Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis

  • Acute Post-Streptococcal Glomerulonephritis

Prostatitis
Immune-Complex Glomerulonephritis
  • Immune Complex Glomerulonephritis

Proliferative Glomerulonephritis
Tick-Borne Relapsing Fever
  • Relapsing Fever, Tick-Borne

  • Relapsing Fever Due To Any Borrelia Species Other Than Borrelia Recurrentis

  • African Tick-Borne Fever

Crescentic Glomerulonephritis
  • Idiopathic Crescentic Glomerulonephritis

Hypersensitivity Vasculitis
  • Cutaneous Small Vessel Vasculitis

  • Hypersensitivity Angiitis

  • Cutaneous Leukocytoclastic Vasculitis

  • Leukocytoclastic Angiitis

  • Vasculitis, Leukocytoclastic, Cutaneous

  • Leukocytoclastic Vasculitis

  • Cutaneous Leukocytoclastic Angiitis

  • Cutaneous Hypersensitivity Vasculitis

  • Vasculitis Hypersensitivity

  • Drug Induced Cutaneous Vasculitis

  • Allergic Vasculitis

Libman-Sacks Endocarditis
  • Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus

Iga Glomerulonephritis
  • Iga Nephropathy

  • Glomerulonephritis, Iga

  • Berger'S Iga Or Igg Nephropathy

  • Focal Glomerulonephritis

  • Primary Iga Nephropathy

  • Segmental Glomerulonephritis

  • Berger Disease

  • Berger'S Disease

  • Igan

  • Nephritis, Iga Type

  • Nephropathy Iga

  • Glomerulonephritis Focal

  • Iga Nephropathy, Susceptibility To

  • Primary Immunoglobulin A Nephropathy

Chronic Monocytic Leukemia
  • Leukemia, Myeloid

  • Leukemia, Monocytic, Chronic

Rapidly Progressive Glomerulonephritis
  • Glomerulonephritis Rapidly Progressive

  • Idiopathic Crescentic Glomerulonephritis

Zebrafish Allergy
  • Danio Rerio Allergy

Ludwig'S Angina
  • Cellulitis Of Floor Of Mouth

  • Ludwig Angina

Relapsing Fever
  • Febris Recurrens

  • Novy Febris Recurrens

  • Novy Relapsing Fever

Henoch-Schoenlein Purpura
  • Henoch-Schonlein Purpura

  • Iga Vasculitis

  • Allergic Purpura

  • Anaphylactoid Purpura

  • Rheumatoid Purpura

  • Immunoglobulin A Vasculitis

  • Vascular Purpura

  • Purpura Rheumatica

  • Henoch-Schönlein Purpura

  • Autoimmune Purpura

  • Henoch-Schnlein Purpura

  • Henoch-Sch@Nlein Purpura

  • Henoch-Scholein Purpura

  • Purpura, Autoimmune

  • Henoch Schonlein Purpura

  • Immunoglobulin-A Vasculitis

  • Purpura, Schonlein-Henoch

  • Purpura, Schönlein-Henoch

  • Hsp -

  • Schönlein-Henoch Purpura

Malaria
  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria

Meningococcal Meningitis
  • Meningitis, Meningococcal

  • Meningitis Meningococcal

  • Epidemic Meningitis

  • Meningitis Due To Neisseria Meningitidis

  • Meningococcal Meninges Infection

  • Meningococcal Meningeal Infection

  • Meningococcal Cerebrospinal Inflammation

  • Chronic Meningococcal Arachnoiditis

  • Meningococcal Arachnoiditis

  • Diplococcal Spinal Meningitis

  • Diplococcal Meningitis

  • Meningococcal Cerebrospinal Fever

  • Meningococcal Cerebrospinal Infection

  • Meningococcal Spinal Meningitis

Lipid Metabolism Disorder
  • Dyslipidemia

  • Disorder Of Fatty Acid Metabolism

  • Lipid Metabolism Disorders

  • Fatty Acid Metabolism Disorder

  • Disorder Of Lipid Metabolism

  • Abnormality Of Lipid Metabolism

  • Lipid Metabolism, Inborn Errors

  • Dyslipidemias

  • Disorders Of Lipid Metabolism

  • Congenital Disorders Of Lipid Metabolism

  • Inherited Disorders Of Lipid Metabolism

Anemia, Autoimmune Hemolytic
  • Autoimmune Hemolytic Anemia

  • Idiopathic Autoimmune Hemolytic Anemia

  • Immuno-Hemolytic Anemia

  • Anemia, Hemolytic, Autoimmune

  • Autoimmune Haemolytic Anaemia

  • Autoimmune Hemolytic Anaemia

  • Acquired Autoimmune Hemolytic Anemia

  • Anemia Hemolytic Autoimmune

  • Familial Auto-Immune Hemolytic Anemia

  • Aha

  • Aiha

Anti-Basement Membrane Glomerulonephritis
  • Anti-Gbm Glomerulonephritis

Autoimmune Disease Of Urogenital Tract
Goodpasture Syndrome
  • Anti-Glomerular Basement Membrane Disease

  • Anti-Gbm Disease

  • Pulmonary Renal Syndrome

  • Anti-Glomerular Basement Membrane Antibody Disease

  • Glomerulonephritis - Pulmonary Hemorrhage

  • Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage

  • Anti-Gbm Syndrome

  • Goodpasture'S Syndrome

  • Anti-Basement Membrane Glomerulonephritis

Nephrotic Syndrome
  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis

Autoimmune Disease Of Blood
Mesangial Proliferative Glomerulonephritis
  • Glomerulonephritis - Mesangial Proliferative

  • Mesangial Proliferative Gn

  • Mesangioproliferative Glomerulonephritis

  • Glomerulonephritis Mesangial Proliferative

Cataract 23, Multiple Types
  • Cataract 23

  • CTRCT23

  • Lamellar Cataract 23

  • Cataract 23, Multiple Types, With Or Without Microcornea

  • Isolated Microphthalmia With Cataract 4

  • Mcopct4

  • Cataract, Type 23

  • Microphthalmia, Isolated, With Cataract 4

Hereditary Angioedema
  • Hereditary Angioneurotic Edema

  • Hereditary Angioedema Type 1

  • Hane

  • Angioedema, Hereditary

  • Hae

  • Angioedemas, Hereditary

  • Deficiency Of C1 Esterase Inhibitor

  • C1 Esterase Inhibitor Deficiency

  • C1 Inhibitor Deficiency

  • Familial Angioneurotic Edema

  • Hereditary Bradykinine-Induced Angioedema

  • Hereditary Non Histamine-Induced Angioedema

  • Hae 1

  • Hae-I

  • Hereditary Angioneurotic Edema Type 1

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii

  • Hereditary Angioneurotic Oedema

  • Familial Angioedema

  • Hae - [Hereditary Angioneurotic Oedema]

  • Bannister Disease, Hereditary

  • Quincke Disease Or Oedema

  • Hereditary Quincke Oedema

Thrombocytopenia
  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos

Body Mass Index Quantitative Trait Locus 11
  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis

Retinitis Pigmentosa 46
  • RP46

  • Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related

  • Retinitis Pigmentosa Autosomal Recessive Idh3b-Related

  • Retinitis Pigmentosa, Type 46

3mc Syndrome
  • Craniofacial-Ulnar-Renal Syndrome

  • Malpuech Facial Clefting Syndrome

  • Oculopalatoskeletal Syndrome

  • Carnevale Syndrome

  • Michels Syndrome

  • Malpuech-Michels-Mingarelli-Carnevale Syndrome

  • Carnevale-Krajewska-Fischetto Syndrome

  • Craniosynostosis With Lid Anomalies

  • Malpuech Syndrome

  • Mingarelli Syndrome

  • Oculo-Skeletal-Abdominal Syndrome

  • Osa Syndrome

  • Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

  • Ptosis-Strabismus-Rectus Abdominis Diastasis

Diabetes Mellitus
  • Diabetes

Eye Degenerative Disease
Autoimmune Disease Of Musculoskeletal System
Type 2 Diabetes Mellitus
  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes

Blood Platelet Disease
  • Platelet Disorder

  • Blood Platelet Disorders

  • Thrombocytopathy

  • Platelet Dysfunction

  • Platelet Disorders

  • Qualitative Platelet Deficiency

Cystic Fibrosis
  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis

Prader-Willi Syndrome
  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat

Hypertension, Essential
  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration

Skin Disease
  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders

Nervous System Disease
  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta C3 VGNC VGNC:108484
Mus musculus C3 MGD MGI:88227
Rattus norvegicus C3 RGD RGD:2232
Bos taurus C3 VGNC VGNC:26638
Canis familiaris C3 VGNC VGNC:38591
Others C3 NCBI