2. Gene
  3. Src - Rous sarcoma oncogene Gene

Src - Rous sarcoma oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as pp60c-src

Gene ID: 20779 | Gene type: protein coding

About Src

Chromosome 2: 157,260,364-157,313,782 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 261 orthologues, 32 paralogues and is associated with 54 phenotypes. Ubiquitous expression in duodenum adult (RPKM 49.), colon adult (RPKM 48.4) and 23 other tissues.

Summary

Enables several functions, including connexin binding activity; Ephrin Receptor binding activity; and scaffold protein binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; positive regulation of signal transduction; and protein destabilization. Acts upstream of or within several processes, including animal organ development; cellular response to growth factor stimulus; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal Cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human Src (Src proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Src Products(13)

mRNA Protein Name
NM_001412690.1 NP_001399619.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412691.1 NP_001399620.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001025395.3 NP_001020566.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412689.1 NP_001399618.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412693.1 NP_001399622.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412682.1 NP_001399611.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412683.1 NP_001399612.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_009271.4 NP_033297.2 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412687.1 NP_001399616.1 proto-oncogene tyrosine-protein kinase Src isoform 2
NM_001412686.1 NP_001399615.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412684.1 NP_001399613.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412685.1 NP_001399614.1 proto-oncogene tyrosine-protein kinase Src isoform 1
NM_001412688.1 NP_001399617.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Src Protein Structure

SH3_Src

SH3_Src: cd12008 (86 - 141)

SH2_Src_Src

SH2_Src_Src: cd10365 (145 - 245)

PTKc_Src

PTKc_Src: cd05071 (258 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase Src

neuronal proto-oncogene tyrosine-protein kinase Src

p60-Src

proto-oncogene c-Src

Recombinant Src Proteins

Cat. No. Product Name Accession Purity
HY-P73423 Src Protein, Mouse (sf9, His-GST) P05480-2 (M1-L535) ≥95%

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10181 Dasatinib Inhibitor 99.88% Yes
HY-12047 Ponatinib Inhibitor 99.43% Yes
HY-10158 Bosutinib Inhibitor 99.96% Yes
HY-10209 Masitinib Inhibitor 99.98% Yes
HY-10181A Dasatinib hydrochloride Inhibitor 98.86% Yes
HY-108766 Ponatinib hydrochloride Inhibitor 99.55% Yes
HY-10209A Masitinib mesylate Inhibitor 99.83% Yes
Clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-10234 Saracatinib Inhibitor 99.92% Phase 3
HY-10340 Tirbanibulin Inhibitor 99.56% Phase 3
HY-10340B Tirbanibulin Mesylate Inhibitor 99.97% Phase 3
HY-10340A Tirbanibulin dihydrochloride Inhibitor 99.59% Phase 3
HY-13024 Rebastinib Inhibitor 99.91% Phase 2
HY-50868 Bafetinib Inhibitor 99.77% Phase 2
HY-32718 Pelitinib Inhibitor 98.80% Phase 2
HY-59047 Tolimidone Activator 99.89% Phase 2
HY-111787 Elzovantinib Inhibitor 99.97% Phase 2
HY-10987A ENMD-2076 Inhibitor 99.12% Phase 2
HY-10987 ENMD-2076 Tartrate Inhibitor 99.42% Phase 2
HY-10186 TG 100801 Inhibitor 98.60% Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-15749 XL228 Inhibitor 99.29% Phase 1
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
HY-112314 AZD0424 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (103)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13805 PP2 Inhibitor 99.35% Unkown
HY-12299 WH-4-023 Inhibitor 99.75% Unkown
HY-15764A A 419259 trihydrochloride Inhibitor 99.21% Unkown
HY-12072 Lck Inhibitor Inhibitor 99.45% Unkown
HY-13804 PP1 Inhibitor 99.00% Unkown
HY-B0789 SU6656 Inhibitor 98.05% Unkown
HY-101053 Src Inhibitor 1 Inhibitor 99.96% Unkown
HY-112096 eCF506 Inhibitor 99.30% Unkown
HY-13942 1-NM-PP1 Inhibitor 99.28% Unkown
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-13941 1-Naphthyl PP1 Inhibitor 99.08% Unkown
HY-N0752 Scutellarein Inhibitor 99.25% Unkown
HY-112852 TL02-59 Inhibitor 99.84% Unkown
HY-135299 CH6953755 Inhibitor 98.03% Unkown
HY-11011 A-770041 Inhibitor 99.95% Unkown
HY-130254 Src Inhibitor 3 Inhibitor 98.61% Unkown
HY-108318 RK-24466 Inhibitor 98.53% Unkown
HY-10395 PD173955 Inhibitor 99.12% Unkown
HY-W062835 CGP77675 Inhibitor 99.00% Unkown
HY-10372 PP121 Inhibitor 98.67% Unkown
HY-13561 AZM475271 Inhibitor 99.85% Unkown
HY-112182 UM-164 Inhibitor 99.15% Unkown
HY-P3279 EPQpYEEIPIYL Activator 98.94% Unkown
HY-139147 iHCK-37 Inhibitor 99.69% Unkown
HY-136605 DGY-06-116 Inhibitor 99.54% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-15764 A 419259 Inhibitor 98.23% Unkown
HY-18303 AMG-47a Inhibitor 99.34% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.81% Unkown
HY-78263 MNS Inhibitor 99.55% Unkown
HY-155657 BT424 Inhibitor / Unkown
HY-10185 TG 100572 Hydrochloride Inhibitor 98.96% Unkown
HY-13941B 1-Naphthyl PP1 hydrochloride Inhibitor 99.94% Unkown
HY-108485 Damnacanthal Inhibitor ≥98.0% Unkown
HY-18622 PP58 Inhibitor 99.75% Unkown
HY-P1377A Caffeic acid-pYEEIE TFA 98.50% Unkown
HY-120213 YH-306 Inhibitor 98.01% Unkown
HY-107024 Osteogenic Growth Peptide (10-14) Inhibitor 99.69% Unkown
HY-108488 KB SRC 4 Inhibitor 99.66% Unkown
HY-127002 Squarunkin A Inhibitor 99.34% Unkown
HY-103274 PD180970 Inhibitor 99.27% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-163144 DAS-5-oCRBN Degrader / Unkown
HY-125028 Hck-IN-1 Inhibitor 98.53% Unkown
HY-N4201 β-Hydroxyisovalerylshikonin Inhibitor 99.83% Unkown
HY-118144 PD166326 Inhibitor 99.99% Unkown
HY-120595 JNJ-49095397 Inhibitor 99.85% Unkown
HY-132150A HPK1-IN-2 dihydrochloride Inhibitor 98.69% Unkown
HY-W013857 Lavendustin C Inhibitor 98.32% Unkown
HY-N6596 7-Hydroxy-4-chromone Inhibitor 99.94% Unkown
HY-N4127 3'-Demethylnobiletin 99.98% Unkown
HY-122113 PD173952 Inhibitor / Unkown
HY-123506 Fenlean Inhibitor 99.56% Unkown
HY-18237 KX1-004 Inhibitor 99.75% Unkown
HY-18507 AD57 Inhibitor 98.08% Unkown
HY-10158S Bosutinib-d8 Inhibitor ≥99.0% Unkown
HY-15764G A 419259 (GMP) Inhibitor / Unkown
HY-10184 TG 100572 Inhibitor / Unkown
HY-10234A Saracatinib difumarate Inhibitor 99.24% Yes
HY-112852A TL02-59 dihydrochloride Inhibitor / Unkown
HY-15324 PRT062607 acetate Inhibitor / Unkown
HY-W745090 Isomaltulose monohydrate Inhibitor / Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor / Unkown
HY-102073 TG53 Inhibitor / Unkown
HY-157497 DA5-HTL Inhibitor / Unkown
HY-10363 AP 24149 Inhibitor / Unkown
HY-112335 Lck Inhibitor III Inhibitor / Unkown
HY-157998 mG2N001 / Unkown
HY-123298 Chrysotoxine Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-P1377 Caffeic acid-pYEEIE / Unkown
HY-W062835A CGP77675 hydrate Inhibitor / Unkown
HY-162291 Lck-IN-3 Inhibitor / Unkown
HY-146014 Multi-kinase-IN-1 Inhibitor / Unkown
HY-157290 HL403 Inhibitor / Unkown
HY-P1200A Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Inhibitor / Unkown
HY-13342AS Apatinib-d8 free base 92.56% Unkown
HY-115723 Antiallergic agent-1 Inhibitor / Unkown
HY-147314 HIV-IN-6 98.35% Unkown
HY-W744699 Larixol Inhibitor / Unkown
HY-110367A LCB 03-0110 Inhibitor / Unkown
HY-15268 PP487 Inhibitor / Unkown
HY-P2547 Tyrosine Kinase Peptide 1 / Unkown
HY-128397 CpCDPK1/TgCDPK1-IN-1 Inhibitor / Unkown
HY-111187 KX2-361 Inhibitor 99.55% Unkown
HY-112291 SB 220025 Inhibitor / Unkown
HY-138202 Lck-IN-1 Inhibitor / Unkown
HY-139890 DC-Srci-6649 Inhibitor / Unkown
HY-150026 Multi-kinase-IN-2 Inhibitor / Unkown
HY-110367 LCB 03-0110 dihydrochloride Inhibitor / Unkown
HY-163278 Lck-IN-2 Inhibitor / Unkown
HY-P1200 Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Inhibitor / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-12847 CCT241161 Inhibitor / Unkown
HY-127002A Squarunkin A hydrochloride Inhibitor / Unkown
HY-15814 HG-7-85-01 Inhibitor 99.94% Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-108016 Peruvoside Inhibitor / Unkown
HY-15805 KIN-8194 Inhibitor / Unkown
HY-P3773 p60c-src substrate II / Unkown
HY-N7160 2-Hydroxy-3-methylanthraquinone Inhibitor / Unkown
HY-W700620 Hydroxymethyl dasatinib Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Src NCBI NCBI:6714