Myc - MYC proto-oncogene, bHLH transcription factor Gene
Also Known as mMyc; c-myc; RNCMYC
Species: Rattus norvegicus
About Myc
This gene has 1 transcript (splice variant), 217 orthologues, 4 paralogues and is associated with 102 phenotypes. Biased expression in Spleen (RPKM 98.), Thymus (RPKM 64.5) and 9 other tissues.
Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]
Myc Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_012603.2 | NP_036735.2 | myc proto-oncogene protein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA binding |
IDA
IDA: Inferred from direct assay
|
11799123 | RGD |
| enables DNA-binding transcription factor activity |
IDA
IDA: Inferred from direct assay
|
15139290 | RGD |
| enables DNA-binding transcription factor activity |
IMP
IMP: Inferred from mutant phenotype
|
17341548 | RGD |
| enables double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
15139290 | RGD |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17334388 | RGD |
| enables protein-containing complex binding |
IPI
IPI: Inferred from physical interaction
|
17341548 | RGD |
| enables sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
15139290 | RGD |
Myc Protein Structure
Myc_N: pfam01056 (15 - 358)
bHLHzip_c-Myc: cd11458 (364 - 447)
- 0
- 100
- 200
- 300
- 400
- 453 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myc proto-oncogene protein |
|
|