Hdac1 - histone deacetylase 1 Gene
Also Known as HD1; RPD3; MommeD5; Hdac1-ps
Species: Mus musculus
About Hdac1
This gene has 7 transcripts (splice variants), 277 orthologues, 10 paralogues and is associated with 31 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 54.8), placenta adult (RPKM 51.1) and 28 other tissues.
Summary
Enables several functions, including E-box binding activity; Krueppel-associated box domain binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in heterochromatin; neuronal cell body; and nucleus. Part of NuRD complex and transcription repressor complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Hdac1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_008228.3 | NP_032254.1 | histone deacetylase 1 |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of NuRD complex |
IDA
IDA: Inferred from direct assay
|
11836251 | MGI |
| part of NuRD complex |
IPI
IPI: Inferred from physical interaction
|
14645126 | MGI |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
21093383 | MGI |
| located in heterochromatin |
IDA
IDA: Inferred from direct assay
|
14519686 | MGI |
| part of histone deacetylase complex |
IPI
IPI: Inferred from physical interaction
|
14645126 | MGI |
| located in neuronal cell body |
IDA
IDA: Inferred from direct assay
|
18651664 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11115394 | MGI |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
19796622 | MGI |
| part of transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
17707228 | MGI |
| part of transcription regulator complex |
IPI
IPI: Inferred from physical interaction
|
17182846 | MGI |
| part of transcription repressor complex |
IPI
IPI: Inferred from physical interaction
|
17182846 | MGI |
Hdac1 Protein Structure
HDAC1: cd10010 (3 - 373)
- 0
- 100
- 200
- 300
- 400
- 482 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
histone deacetylase 1 |
|