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Pan-Adrenergic Signaling and Seizure Suppression

Intercellular Communication & Diseases Chronic Inflammation Calcium Homeostasis Cellular Stress

Here, seizure suppression concerns prevention of later spontaneous seizures after status epilepticus, not immediate termination of an active clinical seizure. Pan-adrenergic regulation refers to simultaneous manipulation of several α- and β-adrenergic receptor classes rather than selective modulation of one receptor. In the seizure study most directly matching this topic, the intervention was pan-adrenergic inhibition: propranolol, prazosin, and atipamezole jointly blocked β-, α1-, and α2-receptor signaling. The rationale arose from work showing that brain-state-dependent fluid movement changes extracellular-solute clearance. Cerebrospinal fluid enters along periarterial routes, exchanges with interstitial fluid, and drains solutes along perivenous pathways; astrocytic aquaporin-4 contributes to this transport. Sleep expands interstitial space and increases cerebrospinal-fluid-interstitial-fluid exchange in mice[1][2][3].

Status epilepticus releases glutamate and other active molecules and can initiate epileptogenesis, the process through which a previously normal brain develops spontaneous seizures. In adult male mice given intrahippocampal kainic acid, acute combined adrenergic antagonism enhanced glymphatic flow, reduced later spontaneous-seizure severity, reduced reactive gliosis, and limited loss of polarized AQP4 at astrocytic vascular endfeet. Treatment initiated 30 hours after kainate, after status epilepticus had ceased, also suppressed epileptogenesis. Conversely, Aqp4 deletion produced chronically reduced fluid transport and worsened epileptogenesis in this model, linking adrenergic state, astrocytic water-channel organization, clearance, and later network pathology[4].

The study suggests a disease-modifying strategy distinct from acute ion-channel suppression. Instead of only terminating an ongoing seizure, temporary pan-adrenergic blockade during a post-status window may improve extracellular clearance and alter the glial environment that supports chronic epileptogenesis. Applications include mechanistic studies of post-status epilepsy, AQP4 polarization, reactive astrocytes, extracellular glutamate and protein clearance, sleep-wake physiology, and timing of preventive treatment. The approach also supplies a pharmacological probe for asking whether enhanced glymphatic transport causes benefit or merely accompanies lower arousal. It does not establish that chronic adrenergic blockade treats established human epilepsy or that every seizure syndrome depends on impaired clearance[1][2][3][4].

Translation requires caution because α- and β-adrenergic receptors regulate blood pressure, heart rate, arousal, sleep, memory, and immune and vascular function. The three-drug combination may alter cerebral perfusion or behavior independently of fluid transport, and the principal experiment used one kainate model in male mice. Future work should replicate across sexes, ages, induction methods, species, and genetic epilepsy models; include electroencephalographic seizure burden, sleep state, perfusion, interstitial volume, tracer kinetics, AQP4 localization, inflammation, cognition, and cardiovascular safety. Receptor-specific deletion in astrocytes, neurons, vascular cells, and immune cells can identify which blockade is necessary and whether all three antagonists are required. Studies should compare intervention during status, after status, and after spontaneous seizures begin to define the therapeutic window. AQP4 rescue or disruption can test mediation rather than correlation. Human translation would require a tolerable regimen, central target-engagement marker, quantitative imaging or fluid-transport biomarker, and controlled trials in a population at measurable risk of post-injury epilepsy. The mechanistic insight is compelling but narrow: transient pan-adrenergic inhibition suppressed epileptogenesis in a defined mouse model, and its value now depends on separating glymphatic causality from systemic adrenergic effects[1][2][3][4].

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Cat. No. Product Name Information Application Publication
HY-B0468 Isoprenaline hydrochloride
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.
Adrenergic Receptor  
Obesity  
97
HY-L044 Nucleotide Compound Library
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications. MCE offers a unique collection of 593 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Structure Classified Libraries

89
HY-L089 Mitochondria-Targeted Compound Library
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,182 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Signaling Pathway Targeting Libraries

89
HY-L036 Covalent Screening Library
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 1,618 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

Structure Classified Libraries

87
HY-L067 Antibiotics Library
Antibiotics are types of antimicrobial products used for the treatment and prevention of bacterial infections. Antibiotics can kill or inhibit bacterial growth. Although the target of an antibiotic is bacteria, some antibiotics also attack fungi and protozoans. However, antibiotics rarely have an effect on viruses. The major mechanism underlying antibiotics is the inhibition or regulation of enzymes involved in cell wall biosynthesis, nucleic acid metabolism and repair, protein synthesis, or disruption of membrane structure. Many of these cellular functions targeted by antibiotics are most active in multiplying cells. Since there is often overlap in these functions between prokaryotic bacterial cells and eukaryotic mammalian cells, it is not surprising that some antibiotics have also been found to be useful as anticancer agents. MCE supplies a unique collection of 748 antibiotics, including penicillins, cephalosporins, tetracyclines, macrolides, etc. MCE Antibiotics Library is a useful tool for anti-bacterial or anti-cancer drugs discovery.

Compound Characteristic Classified Libraries

85
HY-L130 Non-steroidal Anti-Inflammatory Compound Library
Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen. The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity. MCE offers a unique collection of 635 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

Disease Focused Libraries Compound Characteristic Classified Libraries

84
HY-L036P Covalent Screening Library Plus
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 6,121 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc. MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Structure Classified Libraries

83
HY-L193 PBCRBS Traditional Chinese Medicine Compound Library
Since ancient times, promoting blood circulation for removing blood stasis (PBCRBS) has been one of the most popular research contents in the area of traditional Chinese medicine (TCM) and integrated medicine. Rhizoma, Persicae Semen, Carthami Flos, Curcumae Longae Rhizoma and so on are common TCM with PBCRBS characteristic. Studies have shown that the mechanism of action of PBCRBS TCM is to promote blood circulation (improving cardiovascular and cerebrovascular functions, physical and chemical properties of blood, platelet and coagulation system and other physiological functions) and remove blood stasis (anti-myocardial ischemia, cerebral ischemia, inhibition of platelet aggregation, anti-coagulation, anti-thrombosis, etc.). Not only that, PBCRBS TCM has anti-infection, inhibit inflammation, regulate immune function, inhibit immune response, inhibit abnormal tissue proliferation and other functions. Therefore, PBCRBS TCM has high research value in all- field disease research fields. MCE can supply 1,006 monomer component from more than a hundred sources of PBCRBS TCM, which can be used in TCM studies, drug development and mechanism-based studies.
83
HY-L264 DNA Damage Repair Inhibitor Library
DNA damage response (DDR) is a fundamental mechanism for maintaining genomic stability. When DNA damage occurs, such as single- or double-strand breaks or replication fork stalling, cells rely on key proteins including ATM, ATR, PARP, and DNA-PK to sense the damage and transmit signals, thereby regulating DNA repair, cell-cycle arrest, and cell death. Inhibition of specific DNA repair or checkpoint pathways can prevent tumor cells from effectively repairing accumulated DNA damage, ultimately leading to tumor cell death. MCE DNA Damage Repair Inhibitor Library contains 1,544 compounds, focusing on key nodes involved in DNA damage response and DNA repair. The library covers multiple DNA repair and cell-cycle checkpoint pathways, providing a systematic compound screening tool for research on precision oncology, synthetic lethality, drug resistance mechanisms, and chemo- or radiosensitization.
83
HY-L908 Lead-like Covalent Screening Library
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

According to Lead-like Structures

83
HY-L922 Good ADMET Diversity Library
A diverse compound library with favorable ADMET properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) is crucial in drug discovery. Early evaluation of ADMET properties allows for the exclusion of molecules with unfavorable profiles at the initial stages, thereby reducing the risk of late-stage development failures, lowering R&D costs, and accelerating optimization of lead compounds. Based on predictions from ADMET-related AI algorithms, the compounds in this library are predicted to exhibit favorable oral bioavailability (F > 30%), reasonable plasma protein binding (PPB < 98%), minimized CYP3A4 inhibition potential (inhibition probability < 50%, CYP3A4 is the most critical drug-metabolizing enzyme in the cytochrome P450 family) , low toxicity profiles, with 140 potentially toxic substructures pre-identified and excluded via substructure searching to eliminate compounds containing hazardous fragments. The diversity library enables broad applicability in high-throughput screening (HTS) and high-content screening (HCS).

Distinctive Diversity Libraries

83
HY-13715A Norepinephrine hydrochloride
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.
Adrenergic Receptor   Autophagy   Endogenous Metabolite  
Cancer   Depression   Cardiovascular Disease   Glucose Metabolism   Obesity  
79
HY-13715 Norepinephrine
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.
Endogenous Metabolite   Adrenergic Receptor   Autophagy  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
79
HY-B1618 Corticosterone
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Glucocorticoid Receptor   Endogenous Metabolite   iGluR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   SARS-CoV-2 Infection   Osteoarthritis  
71
HY-15084B Dizocilpine
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
iGluR  
Schizophrenia   Depression   Alzheimer's Disease   Parkinson's Disease  
52
HY-15084 Dizocilpine maleate
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
52
HY-B0573 Propranolol hydrochloride
Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
Adrenergic Receptor   Bacterial  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Depression   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension  
52
HY-B0573B Propranolol
Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
Adrenergic Receptor   Bacterial  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Depression   Alzheimer's Disease   Psoriasis   Hypertension  
52
HY-13951 Zenidolol hydrochloride
Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
Adrenergic Receptor  
Metabolic or Endocrine Disease   Depression   Alzheimer's Disease   Hypertension  
50
HY-B0769 Phenylephrine
(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.
Adrenergic Receptor  
Cancer   Viral Infection   Depression   Cardiovascular Disease   Obesity  
38
HY-100714A D-AP5
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
37
HY-17551 NMDA
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
iGluR   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
33
HY-B1102 Evans Blue
Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability.
EAAT   iGluR  
Neurodegenerative Disease   Cardiovascular Disease  
33
HY-116771A CL 316243
CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors.CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
Adrenergic Receptor  
Depression   Glucose Metabolism   Obesity  
28
HY-B1302 Quinidine hydrochloride monohydrate
Quinidine hydrochloride monohydrate is an orally active antiarrhythmic agent. Quinidine hydrochloride monohydrate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride monohydrate exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride monohydrate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride monohydrate can be used in studies related to uterine sarcoma and seizures.
P-glycoprotein   PARP   Caspase   Apoptosis   Potassium Channel  
Epilepsy   Cardiovascular Disease   Alzheimer's Disease  
24
HY-17498 Atenolol
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.
Adrenergic Receptor  
Cancer   Metabolic or Endocrine Disease   Depression   Alzheimer's Disease   Hypertension  
21
HY-Y0966 Glycine
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.
Ninjurin   Endogenous Metabolite   VEGFR   PROTAC Linkers   iGluR  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Schizophrenia   Pain   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Multiple Myeloma   HSV Infection   SARS-CoV-2 Infection   Alzheimer's Disease   Lung Fibrosis  
18
HY-14608 L-Glutamic acid
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
Environmental Pollutants   Ferroptosis   iGluR   Endogenous Metabolite   Apoptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
16
HY-N0378 D-Mannitol
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
Environmental Pollutants   PGC-1α   Apoptosis   Adrenergic Receptor   Endogenous Metabolite   PKA  
Digestive System Disease   Prostate Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Parkinson's Disease   Obesity  
15
HY-12882A Ifenprodil tartrate
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM). Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease.
iGluR   Adrenergic Receptor   Potassium Channel   Calcium Channel   Influenza Virus  
Viral Infection   Depression   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Hypertension   Lung Fibrosis  
12
HY-Y1889A Sodium carboxymethyl cellulose (MW 250000)
Sodium carboxymethyl cellulose (CMC-Na) (MW 250000) is a sodium salt of carboxymethyl cellulose. Sodium carboxymethyl cellulose has adsorption and corrosion inhibition on low-carbon steel in an acidic medium. Sodium carboxymethyl cellulose can be used as a thickener, paste and barrier agent.
Environmental Pollutants   Biochemical Assay Reagents  
12
HY-P9915 Daratumumab
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

Species: Human

CD38   ADC Antibodies  
Inflammation or Immune System Disease   Leukemia/Lymphoma/Myeloma  
12
HY-100806 Kynurenic acid
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
iGluR   Endogenous Metabolite   Apoptosis   CXCR   GPR35  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Depression   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease  
11
HY-148905 p-Aminophenylmercuric acetate
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor.
Cathepsin   MMP  
Infection  
11
HY-N0215 L-Phenylalanine
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

Source: Escherichia coli

Calcium Channel   iGluR   Endogenous Metabolite  
Breast Cancer   Colorectal Cancer   Depression   Pain   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension   Phenylketonuria  
9
HY-P3465 Bulevirtide
Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research.
HBV  
Viral Infection  
8
HY-B0300 Penicillamine
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and increases oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.

Source: Penicillium

Cuproptosis   Drug Metabolite  
Lung Cancer   Breast Cancer   Neurodegenerative Disease   Rheumatoid Arthritis  
4
HY-W010155 Tryptophol
Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.
Endogenous Metabolite   Apoptosis   Caspase   Bacterial  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Digestive System Disease   Bacterial Infection   Digestive System Inflammation   Cardiovascular Disease  
3
HY-K1050 Gentamicin, Sterile

MCE Gentamicin, Sterile (10 mg/mL) is a filtered and sterilized antibiotic solution that can be used directly in cell culture. Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria, mainly for gram-negative and gram-positive bacteria.

Cell Biology Cell Culture Sterile Antibiotic Solution

3
HY-B0661A Tamsulosin hydrochloride
Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
Adrenergic Receptor   Apoptosis  
Metabolic or Endocrine Disease   Prostate Cancer   Depression   Alzheimer's Disease  
2
HY-N2522 Carboxyatractyloside dipotassium
Carboxyatractyloside dipotassium is a diterpenoid. Carboxyatractyloside dipotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside dipotassium is an ADP/ATP carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside dipotassium promotes ROS production, induces Ca2+ release, and leads to mitochondrial dysfunction. Carboxyatractyloside dipotassium induces lethargy, weakness, and epileptic seizures in rats.
Mitochondrial Metabolism   Calcium Channel   Reactive Oxygen Species (ROS)  
Cancer   Digestive System Disease   Digestive System Inflammation   Parkinson's Disease  
2
HY-N1502 Carboxyatractyloside tripotassium
Carboxyatractyloside tripotassium is a diterpenoid. Carboxyatractyloside tripotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside tripotassium is an ADP/ATP carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside tripotassium promotes ROS production, induces Ca2+ release, and leads to mitochondrial dysfunction. Carboxyatractyloside tripotassium induces lethargy, weakness, and epileptic seizures in rats.
Mitochondrial Metabolism   Reactive Oxygen Species (ROS)   Calcium Channel  
Cancer   Digestive System Disease   Digestive System Inflammation   Parkinson's Disease  
2
HY-N3114 Panaxydiol
Panaxydiol exhibits histamine-release inhibition activity. Panaxydiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Histamine Receptor  
Inflammation or Immune System Disease  
1
HY-106150 Eniporide
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
Na+/H+ Exchanger (NHE)  
1
HY-12715S Yohimbine-13C,d3
Yohimbine-13C,d3 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.
Adrenergic Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-P1376A G-Protein antagonist peptide TFA
G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis.
mAChR   Adrenergic Receptor  
Metabolic or Endocrine Disease  
1
HY-12710A Rauwolscine hydrochloride
Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.
Adrenergic Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-N4289 3-Epiursolic Acid
3-Epiursolic Acid is a natural triterpenoid and a competitive inhibitor of Cathepsin L, with an IC50 of 6.5 μM and a Ki of 19.5 μM. 3-Epiursolic Acid acts through competitive inhibition of Cathepsin L. 3-Epiursolic Acid can be used in research on Cathepsin L inhibitors and tumor-associated proteases.
Cathepsin  
Cancer  
1
HY-D0162 Malachite green hemioxalate
Malachite green hemioxalate (MCCK1) is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green hemioxalate has antibacterial activity, which is attributed to inhibition of intracellular enzymes, insertion into DNA and/or interaction with cell membranes. Malachite green hemioxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green hemioxalate exhibits antitumor activity in vitro and in vivo.
Fungal   IKK   NF-κB   Apoptosis  
Cancer   Bacterial Infection  
1
HY-121608 Lumiflavin
Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer.
Fluorescent Dye   Notch  
1
HY-108810 Canakinumab
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease   Pancreatic Cancer   Non-Small Cell Lung Cancer   SARS-CoV-2 Infection   Type 2 Diabetes  
1
HY-N0339S Syringic acid-d6
Syringic acid-d6 is the deuterium labeled Syringic acid. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation.
Bacterial   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W013378S Carbamazepine 10,11 epoxide-d2
Carbamazepine 10,11 epoxide-d2 is the deuterium labeled Carbamazepine 10,11 epoxide. Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures.
Endogenous Metabolite   Isotope-Labeled Compounds  
/
HY-B0192AS Alfuzosin-d3 hydrochloride
Alfuzosin-d3 hydrochloride is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
Isotope-Labeled Compounds   Adrenergic Receptor  
Metabolic or Endocrine Disease  
/
HY-N3097R Pellitorine (Standard)
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.
Reference Standards   TRP Channel   Amyloid-β   Toll-like Receptor (TLR)   Keap1-Nrf2   Heme Oxygenase (HO)   Dihydroorotate Dehydrogenase   Ferroptosis   PAI-1   NF-κB   Proton Pump   Glutathione Peroxidase   Thrombin   Insecticide   Bacterial  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P1345C [DArg10, Aib20] TLQP-21
[DArg10, Aib20] TLQP-21 is a functional antagonist of the complement 3a receptor (C3aR), with EC50 values of 854 nM, 1007 nM, and 1715 nM against human C3aR. [DArg10, Aib20] TLQP-21 recruits β-arrestin, activates Gi3, mediates β-arrestin-dependent receptor internalization, and does not induce calcium influx. [DArg10, Aib20] TLQP-21 inhibits the adrenergic‑induced lipolysis enhancement mediated by TLQP-21 (HY-P1345) and also inhibits the β-hexosaminidase secretion induced by C3a63-77. [DArg10, Aib20] TLQP-21 can be used in research related to asthma and inflammatory diseases.
Drug Derivative   Complement System   Glycosidase   Arrestin  
Allergic Asthma  
/
HY-W699238 S-(-)-Aminoglutethimide D-tartrate
S-(-)-Aminoglutethimide D-tartrate is an aromatase inhibitor with activity that blocks adrenal steroidogenesis. S-(-)-Aminoglutethimide D-tartrate can be used to inhibit steroid-related diseases. S-(-)-Aminoglutethimide D-tartrate is often used clinically to control certain types of cancer. S-(-)-Aminoglutethimide D-tartrate effectively reduces testosterone and estrogen levels through an enzyme inhibition mechanism.
Biochemical Assay Reagents  
/
HY-B0192AS1 Alfuzosin-d7 hydrochloride
Alfuzosin-d7 (hydrochloride) is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
Isotope-Labeled Compounds   Adrenergic Receptor  
Metabolic or Endocrine Disease  
/
HY-P10937A AQP4 (205-215) TFA
AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO).
Aquaporin  
Inflammation or Immune System Disease  
/
HY-N0382S Galangin-13C3
Galangin-13C3 is the 13C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.
Isotope-Labeled Compounds   Cytochrome P450   Autophagy  
Cancer  
/
HY-N10211 Saccharothrixin K
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureus ATCC25923 with MIC values of 16 μg/mL.

Source: Saccharothrix sp.

Bacterial   Endogenous Metabolite  
Infection  
/
HY-P1327 BVD 10
BVD 10, a neuropeptide Y (NPY) analogue peptide, is a highly selective NPY Y1 receptor antagonist. BVD10 significantly prevents NPY-induced glutamate increase. BVD 10 can be used for seizure research.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-12278G K02288 (GMP)
K02288 (GMP) is K02288 (HY-12278) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
TGF-β Receptor  
Cancer  
/
HY-P5987 Calmodulin Kinase IINtide, Myristoylated
Calmodulin Kinase IINtide, Myristoylated (Myr-CaMKIINtide) is a selective and noncompetitive inhibitor of CaMKII.
CaMK  
Neurological, Eye or Ear Disease  
/
HY-P2707 α-Dendrotoxin
α-Dendrotoxin (α-DTX) is a voltage-gated K+ channel blocker and an acid-sensing ion channel (ASIC) inhibitor. α-Dendrotoxin blocks Kv1.1, Kv1.2, Kv1.6 and D-type (ID) voltage-gated K+ channels, and reversibly inhibits slowly inactivating potassium currents. α-Dendrotoxin induces epilepsy-related behaviors in mice. α-Dendrotoxin can be used in studies related to tonic-clonic seizures.
Sodium Channel   Potassium Channel  
Epilepsy  
/
HY-N10755 (+)-ε-Viniferin
(+)-ε-Viniferin is a stilbenes compound with PGE2 inhibition effect, and is an orally active anti-inflammatory agent. ε-viniferin is also able to reduce fat accumulation, thus can be used for research of inflammation or obesity.
PGE synthase  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-14187S1 Amiodarone-d5 hydrochloride
Amiodarone-d5 hydrochloride is deuterated labeled Amiodarone (HY-14187). Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
Autophagy   Potassium Channel   Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-N2511S Trimyristin--d15
Trimyristin--d15 is the d15-labeled Trimyristin (HY-N2511). Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC50 values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity.
Isotope-Labeled Compounds   Cholinesterase (ChE)   Phosphatase  
Neurological, Eye or Ear Disease   Parasitic Infection  
/
HY-W008226R Phloracetophenone (Standard)
Oxprenolol (hydrochloride) (Standard) is the analytical standard of Oxprenolol (hydrochloride). This product is intended for research and analytical applications. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.
Reference Standards   Cytochrome P450   Bacterial   Antibiotic  
Infection   Metabolic or Endocrine Disease  
/
HY-119802S Practolol-d7
Practolol-d7 is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.
Isotope-Labeled Compounds   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-114703S Eslicarbazepine-d3
Eslicarbazepine-d3 (BIA 2-194-d3) is the deuterium labeled Eslicarbazepine (HY-114703). Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
Isotope-Labeled Compounds   Sodium Channel   Beta-secretase  
Neurological, Eye or Ear Disease  
/
HY-W751152 α,β-Thujone
α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses.
GABA Receptor  
Cancer  
/
HY-W751152R α,β-Thujone (Standard)
α,β-Thujone (Standard) is the analytical standard of α,β-Thujone. This product is intended for research and analytical applications. α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses.
Others   Reference Standards  
Cancer  
/
HY-B0532S Trifluoperazine-d8
Trifluoperazine-d8 is a deuterium labeled Trifluoperazine. Trifluoperazine is an antipsychotic phenothiazine agent and a selective α1-adrenergic receptor antagonist. Trifluoperazine is also a potent dopamine D2 receptor inhibitor .
Isotope-Labeled Compounds   Adrenergic Receptor   Dopamine Receptor   Influenza Virus   Autophagy  
Cancer   Neurological, Eye or Ear Disease  
/
HY-N7156 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone, isolated from Parinari hypochrysea (Chrysobalanaceae), exhibits antioxidant and lipoxygenase inhibition.
Lipoxygenase  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P6176 JLB2-110c
JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect.
Melanocortin Receptor  
Metabolic or Endocrine Disease  
/
HY-P991248 TTX-080
TTX-080 is a humanized monoclonal antagonistic antibody targeting human leukocyte antigen G (HLA-G). TTX-080 exerts anti-tumor activity by relieving HLA-G-mediated immune suppression. TTX-080 is promising for research of solid tumors such as metastatic colorectal cancer (mCRC) and head and neck squamous cell carcinoma (mHNSCC).

Species: Human

Others  
Cancer  
/
HY-D1472 Azure A eosinate
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candida albicans.
Fluorescent Dye  
/
HY-W002116S Methyl syringate-d6
Methyl syringate-d6 is the deuterium labeled Methyl syringate. Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.
TRP Channel   COX   Phosphatase   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P11382 Octadecaneuropeptide
Octadecaneuropeptide is an 18-residue peptide. Octadecaneuropeptide can be derived from Diazepam binding inhibitor. Octadecaneuropeptide includes a specific ligand for the gamma-aminobutyric acid receptor regulatory site occupied by beta-carbolines. Octadecaneuropeptide elicits a dose-related facilitation of the punishment- elicited suppression of drinking.
GABA Receptor  
Neurological, Eye or Ear Disease  
/
HY-P11004 A3-APO
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus.
Bacterial   Antibiotic  
/
HY-P991773 Anti-Mouse CD11b Antibody (5C6)
Anti-Mouse CD11b Antibody (5C6) is a CD11b blocking antibody. Anti-Mouse CD11b Antibody (5C6) can be used for in vitro inhibition of myelomonocytic cell adhesion and in vivo inhibition of inflammatory cell recruitment. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).

Species: Mouse

Integrin  
Inflammation or Immune System Disease  
/
HY-P10985 CTX-1211
CTX-1211 is a selective, orally effective melanocortin MC4R agonist (EC50=0.38 nM). CTX-1211 can enhance the feeding suppression and weight loss effects induced by liraglutide (HY-P0014), and promote anorexia and weight loss activity. CTX-1211 is mainly used in the study of obesity and other metabolic disorders.
Melanocortin Receptor  
Metabolic or Endocrine Disease  
/
HY-P11335 Oscillamide Y
Oscillamide Y (Compound 1), a ureido-containing cyclic peptide, is a Chymotrypsin inhibitor. Oscillamide Y can be isolated from freshwater toxic cyanobacterium Oscillatoria agardhii. Oscillamide Y has potent toxicity against fish, daphnid magna and algae with a stimulatory effect for Raphidocelis subcapitata (EC50: 4.62 mg/L). Oscillamide Y induces high luminescence inhibition in Aliivibrio fischeri. Oscillamide Y can be used for ecological development research.
Ser/Thr Protease   Bacterial  
/
HY-P992511 CS2009
CS2009 is a trispecific antibody targeting PD-1, CTLA-4 and VEGFA. CS2009 blocks the interactions of PD-1/PD-L1, CTLA-4/CD80 and VEGFA/VEGFR2, mediates checkpoint inhibition, and suppresses tumor angiogenesis. CS2009 reactivates PD-1/CTLA-4 double-positive tumor-infiltrating T lymphocytes, induces T cell activation, enhances tumor growth inhibition, promotes vascular normalization, improves T lymphocyte infiltration, and converts the immunosuppressive tumor microenvironment into an immunocompetent one. CS2009 can be used for the research of various advanced solid tumors.

Species: Human

PD-1/PD-L1   CTLA-4   VEGFR  
Cancer  
/
HY-P990873 Anti-BRCA1 Antibody (BR64)
Anti-BRCA1 Antibody (BR64) is a kind of mouse IgG1 κ chimeric antibody, targeting to human BRCA1. Anti-BRCA1 Antibody (BR64) reacts with BRCA1 (Breast cancer susceptibility gene 1) involved in tumor suppression, transcription, genomic stability, DNA repair and recombination. Anti-BRCA1 Antibody (BR64) can be used for the detections of immunofluorescence, western blot, and immunoprecipitation in cancer, such as breast and ovarian cancer.

Species: Human

DNA/RNA Synthesis  
Cancer  
/
HY-D0235 Alizarin yellow GG
Alizarin yellow GG is a dye that exhibits corrosion inhibition effects on mild steel against concentrated H2SO4.
Fluorescent Dye  
/
HY-B0841S Acephate-d3
Acephate-d3 is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.
Isotope-Labeled Compounds   Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-B0495S6 Lamotrigine-13C2,15N2,d3
Lamotrigine-13C2,15N2,d3 is 15N and deuterated labeled Lamotrigine (HY-B0495). Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al.
Autophagy   Sodium Channel   Isotope-Labeled Compounds  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P991634 IBI-325
IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research.

Species: Human

CD73   TNF Receptor   Interleukin Related   IFNAR  
Cancer   Inflammation or Immune System Disease  
/
HY-P10049 TAT-TCL1-Akt-in
TAT-TCL1-Akt-in is an Akt inhibitor.
Akt  
Cancer  
/
HY-P10937 AQP4 (205-215)
AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO).
Aquaporin  
Inflammation or Immune System Disease  
/
HY-B1751S1 Quinidine-13C, d2 hydrochloride
Quinidine-13C, d2 hydrochloride is the 13C, d2 labeled Quinidine hydrochloride (HY-W115674). Quinidine hydrochloride is an orally active antiarrhythmic agent. Quinidine hydrochloride reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride can be used in studies related to uterine sarcoma and seizures.
Isotope-Labeled Compounds   P-glycoprotein   PARP   Caspase   Apoptosis   Potassium Channel  
Cervical Cancer   Epilepsy   Heart Disease  
/
HY-118807S Mepyramine-d2
Mepyramine-d2 (Pyrilamine-d2) is the d2-labeled Mepyramine (HY-118807). Mepyramine (Pyrilamine) is a selective histamine H1 receptor antagonist and KCNQ channel inhibitor, with an IC50 of 12.5 μM against KCNQ2/Q3. Mepyramine shows no activity against allergic asthma in mice when used alone, but modulates the effect of JNJ 7777120 (HY-13508) on allergic asthma in mice; it inhibits the development of morphine physical dependence and increases histamine levels in mouse brains. Mepyramine can be used in studies related to seizures, convulsions, allergic asthma and morphine physical dependence.
Isotope-Labeled Compounds   Histamine Receptor   Potassium Channel  
Epilepsy   Allergic Asthma  
/
HY-134567 Ac-VDVAD-CHO
Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM).
Caspase  
/
HY-107233 Saponin CP4
Saponin CP4 is an oleanolic acid derivative which lacks a 23-OH. Saponin CP4 shows no growth inhibition.
Others  
/
HY-N10452 Methyl maslinate
Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research.
Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-114703S1 Eslicarbazepine-d4
Eslicarbazepine-d4 (BIA 2-194-d4) is deuterium labeled Eslicarbazepine. Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
Isotope-Labeled Compounds   Beta-secretase   Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-12848G SAG (GMP)
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
Smo  
Cancer  
/
HY-A0027S Fenspiride-d5 hydrochloride
Fenspiride-d5 hydrochloride is the deuterium labeled Fenspiride hydrochloride (HY-A0027). Fenspiride hydrochloride is an α adrenergic and H1 histamine receptor antagonist.
Isotope-Labeled Compounds   Adrenergic Receptor   Histamine Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P991869 Aquaporumab
Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}

Species: Human

Aquaporin  
Visual System Disease  
/
HY-12390S Lofepramine-d3
Lofepramine-d3 (Lopramine-d3) is the deuterium labeled Lofepramine. Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-B0122S1 Topiramate-13C
Topiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
Isotope-Labeled Compounds   Sodium Channel   Carbonic Anhydrase   Potassium Channel   Calcium Channel   iGluR   GABA Receptor  
Neurological, Eye or Ear Disease  
/
HY-W002116R Methyl syringate (Standard)
Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.
Reference Standards   TRP Channel   COX   Phosphatase   Bacterial  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-A0066AR Tolazoline hydrochloride (Standard)
Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research.
Reference Standards   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-121877S Valnoctamide-d5
Valnoctamide-d5 is the deuterium labeled Valnoctamide. Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors.
Isotope-Labeled Compounds   GABA Receptor  
Neurological, Eye or Ear Disease  
/
HY-P991775 Anti-Rat CTLA-4 Antibody (WKH203)
Anti-Rat CTLA-4 Antibody (WKH203) reacts with rat CTLA-4. Anti-Rat CTLA-4 Antibody (WKH203) binds to the CTLA-4 protein disrupts the key signaling mechanisms linked to the suppression of T cell activity, triggering T cells readily and enhancing the immune system’s capacity to identify and eliminate cancer. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Rat

CTLA-4  
Enhance Immunity  
/
HY-N12427 Litchinol B
Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM.
Tyrosinase  
Cancer  
/
HY-A0019R Paliperidone (Standard)
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.
Drug Metabolite   Reference Standards   Dopamine Receptor   5-HT Receptor   Adrenergic Receptor  
Neurological, Eye or Ear Disease  
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HY-32329S Setiptiline-d3
Setiptiline-d3 is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.
Isotope-Labeled Compounds   5-HT Receptor   Adrenergic Receptor  
Neurological, Eye or Ear Disease  
/
HY-118060R Dipeptide 2 (Standard)
Dipeptide 2 (Standard) is the analytical standard of Dipeptide 2. This product is intended for research and analytical applications. Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient. Dipeptide 2 is an angiotensin-converting Enzyme (ACE).
Angiotensin-converting Enzyme (ACE)   Reference Standards  
Blood or Cardio-cerebrovascular Disease  
/
HY-17000S Tolvaptan-d7
Tolvaptan-d7 is the deuterium labeled Tolvaptan. Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation.
Isotope-Labeled Compounds   Vasopressin Receptor   Autophagy  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W127668 Triethylcholine iodide
Triethylcholine iodide is a choline acetyltransferase inhibitor and a regulator of the acetylcholine synthesis pathway. Triethylcholine iodide inhibits acetylcholine synthesis in brain tissues and blocks neuromuscular and autonomic ganglionic transmission. Triethylcholine iodide exerts weak curare-like effects at extremely high concentrations. Triethylcholine iodide elevates the pentylenetetrazol seizure threshold, alters electroencephalogram patterns in Felis catus, but does not affect the maximal electroshock seizure threshold in Oryctolagus cuniculus. Triethylcholine iodide can be used in seizure-related research.
Acyltransferase  
Epilepsy   Muscle Disease  
/
HY-B0661AR Tamsulosin hydrochloride (Standard)
Tamsulosin (hydrochloride) (Standard) is the analytical standard of Tamsulosin hydrochloride (HY-B0661A). Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
Reference Standards   Adrenergic Receptor   Apoptosis  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-14187S Amiodarone-d10 hydrochloride
Amiodarone-d10 (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
Potassium Channel   Autophagy  
Blood or Cardio-cerebrovascular Disease  
/
HY-P3557A Mibenratide TFA
Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research.
Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-NP0218 Chicken Ovomucoid
Chicken Ovomucoid is a major component of chicken ovalbumin, exhibiting trypsin inhibition and thermal stability.
Ser/Thr Protease  
Inflammation or Immune System Disease  
/
HY-P1401 Protein Kinase C (19-36)
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response.
PKC  
Metabolic or Endocrine Disease  
/
HY-W002299 Boc-D-Leucine monohydrate
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect.
Amino Acid Derivatives  
Neurological, Eye or Ear Disease  
/
HY-W017091 3-Phenoxy-1,2-propanediol
3-Phenoxy-1,2-propanediol (compound 15) is a weak aquaporin 4 (AQP4) inhibitor. 3-Phenoxy-1,2-propanediol is an important intermediate for pharmaceuticals.
Aquaporin  
Neurological, Eye or Ear Disease  
/
HY-W142169 N-Formyl-L-histidine
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM.
Aminoacyl-tRNA Synthetase  
/
HY-N7006 Timosaponin C
Timosaponin C is isolated from Rhizoma Anemarrhenae. Timosaponin C shows weaker NO inhibition in N9 microglial cells.
Others  
Inflammation or Immune System Disease  
/
HY-P10146 Ac-LETD-CHO
Ac-LETD-CHO is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with an IC50 value of 6.71 nM. Ac-LETD-CHO can be used for the research of anticancer.
Caspase  
Cancer  
/
HY-B1270S Isoxsuprine-d6 hydrochloride
Isoxsuprine-d6 (hydrochloride) is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
Isotope-Labeled Compounds   Adrenergic Receptor   iGluR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B0781S Promethazine-d4 hydrochloride
Promethazine-d4 (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.
Histamine Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-134567A Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor (IC50: 46 and 15 nM).
Caspase  
Neurodegenerative Disease  
/
HY-B0122S Topiramate-13C6
Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
Isotope-Labeled Compounds   Potassium Channel   iGluR   Sodium Channel   GABA Receptor   Carbonic Anhydrase   Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-B0982S Pindolol-d7
Pindolol-d7 (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is the antagonist for 5-HT 1A (Ki=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects.
Isotope-Labeled Compounds   5-HT Receptor   Adrenergic Receptor  
Neurological, Eye or Ear Disease  
/
HY-N0113S Hordenine-d6
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production.
Isotope-Labeled Compounds   Bacterial   p38 MAPK   JNK   ERK   Akt   Interleukin Related   TNF Receptor   NO Synthase   COX   Reactive Oxygen Species (ROS)   Microphthalmia Associated Transcription Factor (MITF)   Wnt   β-catenin   Dopamine Receptor   Adrenergic Receptor   5-HT Receptor   Serotonin Transporter   Dopamine Transporter   α-synuclein  
Musculoskeletal and Skin Disease   Pseudomonas Aeruginosa Infection   Parkinson's Disease   Acute Lung Injury  
/
HY-P3557 Mibenratide
Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research.
Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-N3097 Pellitorine
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.
TRP Channel   Amyloid-β   Toll-like Receptor (TLR)   Keap1-Nrf2   Heme Oxygenase (HO)   Dihydroorotate Dehydrogenase   Ferroptosis   PAI-1   NF-κB   ERK   Proton Pump   Glutathione Peroxidase   Thrombin   Insecticide   Bacterial  
Breast Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Alzheimer's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
/
HY-P11335A Oscillamide Y TFA
Oscillamide Y TFA is the trifluoroacetate salt of Oscillamide Y (HY-P11335). Oscillamide Y (Compound 1), a ureido-containing cyclic peptide, is a Chymotrypsin inhibitor. Oscillamide Y can be isolated from freshwater toxic cyanobacterium Oscillatoria agardhii. Oscillamide Y has potent toxicity against fish, daphnid magna and algae with a stimulatory effect for Raphidocelis subcapitata (EC50: 4.62 mg/L). Oscillamide Y induces high luminescence inhibition in Aliivibrio fischeri. Oscillamide Y can be used for ecological development research.
Ser/Thr Protease   Bacterial  
/
HY-P3472 Cyclo(IP)
Cyclo(IP) (Cyclo-(L-Pro-L-Ile)), a Diketopiperazine can be derived From Bacillus thuringiensis JCK-1233, results in suppression of PWD severity and increased the expression of defense-related genes similarly to Bacillus thuringiensis JCK-1233 treatment.
Amino Acid Derivatives  
Inflammation or Immune System Disease  
/
HY-113261S Oleoylcarnitine-d9
Oleoylcarnitine-d9 is deuterium labeled Oleoylcarnitine. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-P991180 TRX-518
TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].

Species: Human

TNF Receptor  
Cancer  
/
HY-N8693 Withanoside IV
Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19).
COX   Amyloid-β   Sirtuin   Reactive Oxygen Species (ROS)   Apoptosis   SARS-CoV  
SARS-CoV-2 Infection   Alzheimer's Disease  
/
HY-P99895 Rulonilimab
Rulonilimab is a human IgG1 monoclonal antibody against PD-1 that targets, binds and inhibits PD-1 and its downstream signalling pathways with potential immune checkpoint inhibition and anti-tumour activity.

Species: Human

PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-D1460 Fluorescein Di-β-D-Glucuronide
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition.
Bacterial   β-glucuronidase  
Infection  
/
HY-N3225 Myricanol
Myricanol is a diarylheptanoid and a Nampt activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through AMPK activation.
NAMPT   Sirtuin   Microtubule/Tubulin   Apoptosis   Autophagy   PDGFR   NF-κB   AMPK  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-D0876 POPSO
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5.
Biochemical Assay Reagents  
/
HY-P991570 Zaptuzumab
Zaptuzumab (AD5-10) is a DR5-specific humanized monoclonal antibody that selectively binds to DR5 with high affinity. Zaptuzumab specifically induces cancer cell death by both caspase-apoptosis and autophagic cell death (ACD). Zaptuzumab activates both ADCC and CDC. Zaptuzumab induces ROS generation and GSH level reduction. Zaptuzumab shows a significant suppression of the tumor growth and good safety in various xenografts mice tumor models.

Species: Human

TNF Receptor   Apoptosis   Caspase   Atg8/LC3   Akt   Beclin1   JNK  
Cancer  
/
HY-P10887 Pegevongitide
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.
Tie   ANGPTL   SARS-CoV   Aquaporin   TNF Receptor   PAI-1   CXCR   P-selectin  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   SARS-CoV-2 Infection  
/
HY-P991181 VTX-1218
VTX-1218 is a VSIG4 inhibitor with human Kd 7.4 nM. VTX-1218 blocks VSIG4 activity, relieves VSIG4-mediated macrophage suppression, repolarizes tumor-associated macrophages and induces T cell activation. VTX-1218 upregulates cytokines and chemokines linked to immune cell recruitment. VTX-1218 can be used for the research of multiple cancer types.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-P99818 Ramatercept
Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.
TGF-β Receptor  
Metabolic or Endocrine Disease  
/
HY-W324391 Coumarin 106
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56).
Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-P991222 AMG-529
AMG-529 is a humanized monoclonal antibody against ASGR1 that binds to ASGR1, blocks ligand binding, and causes a dose-dependent increase in ALP (a biomarker of ASGR1 inhibition). AMG-529 can be used for the research of cardiovascular diseases.

Species: Human

Phosphatase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P99403 Refanezumab
Refanezumab (GSK249320) is a brain-penetrant IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab has the potential for the enhancement of recovery of function poststroke.

Species: Human

Others  
Neurological, Eye or Ear Disease  
/
HY-78197 3,5-Dimethylisoxazole-4-boronic acid pinacol ester
3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of bromodomain inhibitors.
Drug Intermediate  
/
HY-130332 Mitomycin A
Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases.
Macrophage migration inhibitory factor (MIF)  
Cancer  
/
HY-W002116 Methyl syringate
Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.

Source: honey

TRP Channel   COX   Phosphatase   Bacterial  
Metabolic or Endocrine Disease   Lung Cancer   Gastric Cancer   Bacterial Infection   Pain   Rheumatoid Arthritis  
/
HY-Y0378S D-Leucine-d10
D-Leucine-d10 is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.
Isotope-Labeled Compounds   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-D1606 BODIPY FL prazosin
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes.
Adrenergic Receptor  
Metabolic or Endocrine Disease  
/
HY-N1163 Tetrahydroalstonine
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury.
Adrenergic Receptor   Atg8/LC3   Akt   mTOR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P990961 Palverafusp alfa
Palverafusp alfa (IMM-2510; SYN-2510) is a PD-L1/VEGF-targeting IgG1κ type humanized antibody. Palverafusp alfa blocks PD-1/PD-L1 binding, relieves immune suppression, mediates PD-L1-directed antibody-dependent cellular cytotoxicity (ADCC). Palverafusp alfa blocks VEGF/VEGFR binding, inhibits angiogenic signaling, relieves VEGF-induced immune suppression. Palverafusp alfa reduces endothelial cell proliferation, enhances ADCC and antibody-dependent cellular phagocytosis (ADCP), inhibits tumor growth, reverses T cell immune suppression. Palverafusp alfa exhibits immune stimulatory, antiangiogenic, and anti-tumor activity in the tumor microenvironment. Palverafusp alfa can be used for the research of cancer, such as solid tumors, non-small cell lung cancer.

Species: Human

VEGFR   PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W008270 2(5H)-Furanone
2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures.
Endogenous Metabolite   Bacterial  
Neurological, Eye or Ear Disease   Bacterial Infection  
/
HY-D2869 Ac-H-FluNox
Ac-H-FluNox is an acetylated cell-compatible prodrug of H-FluNox (HY-D2339). Ac-H-FluNox undergoes intracellular hydrolysis of its acetyl group by esterases to generate H-FluNox, which then undergoes a deoxygenation reaction with labile heme to form a fluorescent product. Ac-H-FluNox detects fluctuations of labile heme in living cells, acute labile heme release upon nitric oxide stimulation, and accumulation of labile heme following inhibition of heme export proteins.
Fluorescent Dye   Drug Intermediate  
/
HY-P99794 Osocimab
Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects.

Species: Human

Factor Xa  
Blood or Cardio-cerebrovascular Disease  
/
HY-P99215 Parsatuzumab
Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor (VEGF) inhibition.

Species: Human

VEGFR  
Cancer  
/
HY-137844 L-Leucine-7-amido-4-methylcoumarin hydrochloride
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro.
Fluorescent Dye  
/
HY-A0066A Tolazoline hydrochloride
Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research.
Adrenergic Receptor  
Metabolic or Endocrine Disease   Depression   Alzheimer's Disease   Hypertension  
/
HY-P99203 Cemiplimab
Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research.

Species: Human

PD-1/PD-L1  
Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
/
HY-P99192 Emibetuzumab
Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer.

Species: Human

c-Met/HGFR  
Gastric Cancer   Non-Small Cell Lung Cancer  
/
HY-W004761 Tetrahydroxydiboron
Tetrahydroxydiboron (Hypodiboric acid) acts as a hydrogel initiator and bioadhesion promoter, with broad-spectrum antibacterial activity, ROS scavenging capacity, and osteogenic induction properties. Tetrahydroxydiboron initiates rapid gelation by generating free radicals through reactions with vinyl monomers and dissolved oxygen, overcoming oxygen inhibition without deoxygenation or external triggers. Tetrahydroxydiboron achieves strong bioadhesion via interaction with carboxymethyl chitosan. Tetrahydroxydiboron can be used in the research of periodontitis and related inflammatory diseases.
Bacterial   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Bacterial Infection  
/
HY-W074785 Carboxyl diazirine alkyne
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives.
Biochemical Assay Reagents  
/
HY-P10746 EB1002
EB1002 is a highly selective, long-acting NK2R agonist. EB1002 exerts central appetite suppression, increases peripheral energy expenditure and enhances insulin sensitivity, which effectively reduces body weight, improves glucose and lipid metabolism, with favorable safety profiles. EB1002 can be used for research on diseases such as obesity and type 2 diabetes.
Neurokinin Receptor  
Metabolic or Endocrine Disease  
/
HY-P72087 AQP4 Protein, Human (His-SUMO)
The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His-SUMO) is the recombinant human-derived AQP4 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Human; Source: E. coli

/
HY-P72087A AQP4 Protein, Human (His)
The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His) is the recombinant human-derived AQP4, expressed by E. coli, with N-6*His labeled tag. The total length of AQP4 Protein, Human (His) is 71 a.a..

Species: Human; Source: E. coli

/
HY-P78036 SEZ6/BSRP-C Protein, Human (HEK293, His)
SEZ6/BSRP-C protein is pivotal in cell-cell recognition and neuronal membrane signaling. It maintains balance in dendrite elongation and branching, crucial for complex dendritic arbor development. Additionally, SEZ6/BSRP-C is implicated in establishing proper excitatory synaptic connectivity, emphasizing its role in fundamental processes of neuronal development. SEZ6/BSRP-C Protein, Human (HEK293, His) is the recombinant human-derived SEZ6/BSRP-C protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P704319 SEZ6L Protein, Human (HEK293, His)
SEZ6L Protein, Human (HEK293, His) is the recombinant human-derived SEZ6L protein, expressed by HEK293, with C-His tag.

Species: Human; Source: HEK293

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HY-P702216 AQP4 Protein, Mouse (Cell-Free, His)
The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

Species: Mouse; Source: E. coli Cell-free

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HY-P77200 SEZ6L2/BSRP-A Protein, Human (HEK293, His)
SEZ6L2/BSRP-A, potentially contributing to specialized functions in the endoplasmic reticulum (ER) of neurons, hints at a role critical for neuronal homeostasis.Its significance in the intricate molecular processes essential for neuronal function underscores the need for further exploration to unveil specific mechanisms and pathways through which SEZ6L2/BSRP-A participates in specialized ER functions.SEZ6L2/BSRP-A Protein, Human (HEK293, His) is the recombinant human-derived SEZ6L2/BSRP-A protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P78037 SEZ6/BSRP-C Protein, Mouse (HEK293, His)
The SEZ6/BSRP-C protein contributes significantly to cell-to-cell recognition and neuronal membrane signaling, playing a crucial role in fundamental processes of neural networks.SEZ6/BSRP-C is particularly important in balancing dendritic elongation and branching, which shapes the complex structure of neurons.SEZ6/BSRP-C Protein, Mouse (HEK293, His) is the recombinant mouse-derived SEZ6/BSRP-C protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

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HY-P78038 SEZ6L2/BSRP-A Protein, Mouse (HEK293, His)
The SEZ6L2//BSRP-A protein is a contributor to specialized endoplasmic reticulum function in neurons, implying a unique role in coordinating specific cellular activities. Its identification demonstrates potential effects on the regulation and maintenance of neuronal function, emphasizing its importance in neuronal cellular processes. SEZ6L2/BSRP-A Protein, Mouse (HEK293, His) is the recombinant mouse-derived SEZ6L2//BSRP-A protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

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HY-P700822 SEZ6/BSRP-C Protein, Cynomolgus (HEK293, His)
SEZ6/BSRP-C Protein shows a deficiency in conserved residue(s) essential for feature annotation propagation. SEZ6/BSRP-C Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived SEZ6/BSRP-C protein, expressed by HEK293 , with C-His labeled tag.

Species: Cynomolgus; Source: HEK293

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HY-P703679 SEZ6/BSRP-C Protein, Rat (HEK293, His)
SEZ6/BSRP-C Protein, Rat (HEK293, His) is the recombinant rat-derived SEZ6/BSRP-C protein, expressed by HEK293, with C-His tag.

Species: Rat; Source: HEK293

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HY-P704129 SEZ6L2/BSRP-A Protein, Human (Biotinylated, HEK293, His, Avi)
SEZ6L2/BSRP-A, potentially contributing to specialized functions in the endoplasmic reticulum (ER) of neurons, hints at a role critical for neuronal homeostasis. Its significance in the intricate molecular processes essential for neuronal function underscores the need for further exploration to unveil specific mechanisms and pathways through which SEZ6L2/BSRP-A participates in specialized ER functions. SEZ6L2/BSRP-A Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived SEZ6L2/BSRP-A , Human (Biotinylated, HEK293, His, Avi) protein, expressed by HEK293, with C-His and C-Avi labeled tag.

Species: Human; Source: HEK293

Biotinylated Proteins

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HY-P704876 SEZ6/BSRP-C Protein, Human (HEK293, mFc)
SEZ6/BSRP-C protein is pivotal in cell-cell recognition and neuronal membrane signaling. It maintains balance in dendrite elongation and branching, crucial for complex dendritic arbor development. Additionally, SEZ6/BSRP-C is implicated in establishing proper excitatory synaptic connectivity, emphasizing its role in fundamental processes of neuronal development. SEZ6/BSRP-C, Human (HEK293, mFc) is the recombinant human-derived SEZ6/BSRP-C protein, expressed by HEK293, with C-mFc labeled tag.

Species: Human; Source: HEK293

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HY-P705237 SEZ6/BSRP-C Protein, Human (Biotinylated, HEK293, His-Avi)
SEZ6/BSRP-C protein is pivotal in cell-cell recognition and neuronal membrane signaling. It maintains balance in dendrite elongation and branching, crucial for complex dendritic arbor development. Additionally, SEZ6/BSRP-C is implicated in establishing proper excitatory synaptic connectivity, emphasizing its role in fundamental processes of neuronal development. SEZ6/BSRP-C, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SEZ6/BSRP-C protein, expressed by HEK293, with N-Avi labeled tag.

Species: Human; Source: HEK293

Biotinylated Proteins

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HY-P83459A Aquaporin 4 Antibody
Aquaporin 4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Aquaporin 4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82477 Axin 2 Antibody (YA2222)
Axin 2 Antibody (YA2222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Axin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80317 S100A4 Antibody (YA084)
S100A4 Antibody (YA084) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S100A4.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83506 CD59 Antibody (YA3251)
CD59 Antibody (YA3251) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD59.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P85657 Aquaporin 4 Antibody (YA5349)
Aquaporin 4 Antibody (YA5349) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aquaporin 4.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P81289 NM23A Antibody (YA1002)
NM23A Antibody (YA1002) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NM23A.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P81289A NM23A Antibody (YA1003)
NM23A Antibody (YA1003) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NM23A.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81289AA NM23A Antibody (YA1003)(PBS only)
NM23A Antibody (YA1003) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NM23A.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82477A Axin 2 Antibody (YA2222)(PBS only)
Axin 2 Antibody (YA2222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Axin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83459 Aquaporin 4 Antibody (YA3204)
Aquaporin 4 Antibody (YA3204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 4.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85000 CD59 Antibody (YA4692)
CD59 Antibody (YA4692) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD59.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Nanobodies Primary Antibodies

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HY-P85009 CD82 Antibody (YA4701)
CD82 Antibody (YA4701) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD82.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Nanobodies Primary Antibodies

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HY-P85299 NM23A Antibody (YA4991)
NM23A Antibody (YA4991) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NM23A.

Host: Mouse; Reactivity: Human, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P85433 Hsc70 Interacting Protein Antibody (YA5125)
Hsc70 Interacting Protein Antibody (YA5125) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsc70 Interacting Protein.

Host: Mouse; Reactivity: Human, Bovine, Dog, Pig

Monoclonal Antibodies Primary Antibodies

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HY-P85626 S100A4 Antibody (YA5318)
S100A4 Antibody (YA5318) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to S100A4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85626A S100A4 Antibody (YA5318)(PBS only)
S100A4 Antibody (YA5318) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to S100A4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-K0324 Total Superoxide Dismutase (SOD) Activity Colorimetric Assay Kit (Xanthine Oxidase-NBT Method)

MCE MCE Total Superoxide Dismutase (SOD) Activity Colorimetric Assay Kit (Xanthine Oxidase-NBT Method) is based on the xanthine oxidase–NBT chromogenic system and quantitatively determines total SOD activity in various biological samples by measuring the inhibition of NBT reduction to formazan in the xanthine/xanthine oxidase–generated superoxide system at 560 nm. It is suitable for the determination of SOD activity in cell or tissue homogenate supernatants, whole blood, erythrocyte extracts, serum, and other biological samples.

Cell Biology Cell Analysis Metabolism Assay Kit

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HY-K0325 Total Superoxide Dismutase (SOD) Activity Colorimetric Assay Kit (WST-8 Method)

MCE Total Superoxide Dismutase (SOD) Activity Colorimetric Assay Kit (WST-8 Method) employs a water-soluble tetrazolium salt (WST-8)–based colorimetric system and quantifies total SOD activity in various biological samples by measuring the inhibition of WST-8 reduction to water-soluble formazan in the xanthine/xanthine oxidase system at 450 nm.

Cell Biology Cell Analysis Metabolism Assay Kit

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HY-K6303 Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit

MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

Cell Biology 3D Cell Culture PSC Induction Product Series

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Keywords

pan-adrenergic inhibition | epileptogenesis | status epilepticus | glymphatic transport | aquaporin-4 | reactive gliosis | seizure suppression | adrenergic antagonists