C3 - complement C3 Gene
Also Known as ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Species: Homo sapiens
About C3
This gene has 28 transcripts (splice variants), 268 orthologues, 8 paralogues and is associated with 6 phenotypes. Biased expression in liver (RPKM 1676.7), gall bladder (RPKM 250.0) and 5 other tissues.
Summary
Complement component C3 plays a central role in the activation of Complement System. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
C3 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000064.4 | NP_000055.2 | complement C3 preproprotein |
| NM_000064.4 | NP_000055.2 | complement C3 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables C5L2 anaphylatoxin chemotactic receptor binding |
IDA
IDA: Inferred from direct assay
|
15833747 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7483825 | GOA |
| enables receptor ligand activity |
IDA
IDA: Inferred from direct assay
|
21527715 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
25645918 | GOA |
C3 Protein Structure
A2M_N: MG2 domain (129 - 224)
A2M_N_2: Alpha-2-macroglobulin family N-terminal region (456 - 605)
ANATO: Anaphylotoxin-like domain (693 - 728)
A2M: Alpha-2-macroglobulin family (770 - 866)
Thiol-ester_cl: Alpha-macro-globulin thiol-ester bond-forming region (1000 - 1029)
A2M_comp: A-macroglobulin complement component (1051 - 1283)
A2M_recep: A-macroglobulin receptor (1398 - 1493)
NTR: UNC-6/NTR/C345C module (1534 - 1644)
- 0
- 300
- 600
- 900
- 1200
- 1500
- 1663 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
complement C3 |
|
C3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
C3 | P01024 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
C3 | P01024 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
C3 | P01024 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
C3 | P01024 | CFH | Homo sapiens | P08603 | 21317894 | |
|
Intra
|
C3 | P01024 | CFH | Homo sapiens | P08603 | 21979047 | |
|
Intra
|
C3 | P01024 | CFH | Homo sapiens | P08603 | 21317894 | |
|
Intra
|
C3 | P01024 | CFH | Homo sapiens | P08603 | 21317894 | |
|
Intra
|
C3 | P01024 | CFH | Homo sapiens | P08603 | 21317894 | |
|
Intra
|
C3 | P01024 | CFHR4 | Homo sapiens | Q92496-1 | 22518841 | |
|
Intra
|
C3 | P01024 | Q03591-PRO_0000005896 | Homo sapiens | Q03591-PRO_0000005896 | 27814381 | |
|
Intra
|
C3 | P01024 | CD46 | Homo sapiens | P15529 | 23086448 | |
|
Intra
|
C3 | P01024 | CD46 | Homo sapiens | P15529 | 18796626 | |
|
Intra
|
C3 | P01024 | CR2 | Homo sapiens | P20023 | 21527715 | |
|
Intra
|
C3 | P01024 | CR2 | Homo sapiens | P20023 | 11387479 | |
|
Intra
|
C3 | P01024 | CR2 | Homo sapiens | P20023 | 21527715 | |
|
Intra
|
C3 | P01024 | CR2 | Homo sapiens | P20023 | 11387479 | |
|
Intra
|
C3 | P01024 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
C3 | P01024 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
C3 | P01024 | AGR2 | Homo sapiens | O95994 | 32296183 | |
|
Intra
|
C3 | P01024 | AGR2 | Homo sapiens | O95994 | 32296183 | |
|
Intra
|
C3 | P01024 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
C3 | P01024 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
C3 | P01024 | PLEKHF2 | Homo sapiens | Q9H8W4 | 32296183 | |
|
Intra
|
C3 | P01024 | EFEMP2 | Homo sapiens | O95967 | 32296183 | |
|
Intra
|
C3 | P01024 | EFEMP2 | Homo sapiens | O95967 | 32296183 | |
|
Intra
|
C3 | P01024 | VSIG4 | Homo sapiens | Q9Y279-1 | 16530040 | |
|
Intra
|
C3 | P01024 | VSIG4 | Homo sapiens | Q9Y279-1 | 16530040 | |
|
Intra
|
C3 | P01024 | VSIG4 | Homo sapiens | Q9Y279-1 | 16530040 | |
|
Intra
|
C3 | P01024 | VSIG4 | Homo sapiens | Q9Y279-2 | 16530040 | |
|
Intra
|
C3 | P01024 | VSIG4 | Homo sapiens | Q9Y279-2 | 16530040 | |
|
Intra
|
C3 | P01024 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
C3 | P01024 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
C3 | P01024 | KRT31 | Homo sapiens | Q15323 | 32296183 |
Recombinant C3 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7862 | Complement C3a Protein, Human | P01024 (S672-R748) | ≥ 95%, as determined by reducing SDS-PAGE. |
C3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80577 | C3 Antibody (YA575) | WB, IHC-P | Human |
| HY-P80577A | C3 Antibody (YA575)(PBS only) | WB, IHC-P | Human |
| HY-P83897 | C3C Antibody (YA3594) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P83897A | C3C Antibody (YA3594)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hemolytic Uremic Syndrome, Atypical 5 |
|
|
| Complement Component 3 Deficiency, Autosomal Recessive |
|
|
| Macular Degeneration, Age-Related, 9 |
|
|
| Complement Component 3 Deficiency |
|
|
| Atypical Hemolytic Uremic Syndrome With Complement Gene Abnormality |
|
|
| D-Minus Hemolytic Uremic Syndrome |
|
|
| Hemolytic Uremic Syndrome, Atypical 1 |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
| Genetic Atypical Hemolytic-Uremic Syndrome |
|
|
| Hemolytic-Uremic Syndrome |
|
|
| Glomerulonephritis |
|
|
| Arteriolosclerosis |
|
|
| Complement Deficiency |
|
|
| Retinal Drusen |
|
|
| Hemoglobinuria |
|
|
| Diffuse Glomerulonephritis |
|
|
| Afibrinogenemia, Congenital |
|
|
| Histoplasmosis |
|
|
| Hemolytic Anemia |
|
|
| Louse-Borne Relapsing Fever |
|
|
| Capillary Leak Syndrome |
|
|
| Exudative Glomerulonephritis |
|
|
| Middle Ear Cholesterol Granuloma |
|
|
| Erythema Nodosum |
|
|
| Neuromyelitis Optica |
|
|
| Complement Factor I Deficiency |
|
|
| C3 Glomerulopathy |
|
|
| Hypersensitivity Reaction Type Iii Disease |
|
|
| Eye Disease |
|
|
| Lyme Disease |
|
|
| Herpes Simplex |
|
|
| Pulmonary Tuberculosis |
|
|
| Vasculitis |
|
|
| Epidermolysis Bullosa Dystrophica, Autosomal Dominant |
|
|
| Acute Diffuse Nephritis |
|
|
| Antiphospholipid Syndrome |
|
|
| Hyperlipidemia, Familial Combined, 3 |
|
|
| End Stage Renal Disease |
|
|
| Complement Component 5 Deficiency |
|
|
| Meningococcal Infection |
|
|
| Acute Poststreptococcal Glomerulonephritis |
|
|
| Purpura |
|
|
| Meningitis |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Angioedema |
|
|
| Heart Disease |
|
|
| Lupus Erythematosus |
|
|
| Otitis Media |
|
|
| Systemic Lupus Erythematosus |
|
|
| Pyuria |
|
|
| Degeneration Of Macula And Posterior Pole |
|
|
| Acute Proliferative Glomerulonephritis |
|
|
| Prostatitis |
|
|
| Immune-Complex Glomerulonephritis |
|
|
| Proliferative Glomerulonephritis |
|
|
| Tick-Borne Relapsing Fever |
|
|
| Crescentic Glomerulonephritis |
|
|
| Hypersensitivity Vasculitis |
|
|
| Libman-Sacks Endocarditis |
|
|
| Iga Glomerulonephritis |
|
|
| Chronic Monocytic Leukemia |
|
|
| Rapidly Progressive Glomerulonephritis |
|
|
| Zebrafish Allergy |
|
|
| Ludwig'S Angina |
|
|
| Relapsing Fever |
|
|
| Henoch-Schoenlein Purpura |
|
|
| Malaria |
|
|
| Meningococcal Meningitis |
|
|
| Lipid Metabolism Disorder |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Anti-Basement Membrane Glomerulonephritis |
|
|
| Autoimmune Disease Of Urogenital Tract |
|
|
| Goodpasture Syndrome |
|
|
| Nephrotic Syndrome |
|
|
| Autoimmune Disease Of Blood |
|
|
| Mesangial Proliferative Glomerulonephritis |
|
|
| Cataract 23, Multiple Types |
|
|
| Hereditary Angioedema |
|
|
| Thrombocytopenia |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Retinitis Pigmentosa 46 |
|
|
| 3mc Syndrome |
|
|
| Diabetes Mellitus |
|
|
| Eye Degenerative Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Blood Platelet Disease |
|
|
| Cystic Fibrosis |
|
|
| Prader-Willi Syndrome |
|
|
| Hypertension, Essential |
|
|
| Skin Disease |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | C3 | VGNC | VGNC:108484 |
| Mus musculus | C3 | MGD | MGI:88227 |
| Rattus norvegicus | C3 | RGD | RGD:2232 |
| Bos taurus | C3 | VGNC | VGNC:26638 |
| Canis familiaris | C3 | VGNC | VGNC:38591 |
| Others | C3 | NCBI |