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Lipid Mediators Drive Allergic Inflammatory Responses

Chronic Inflammation Intercellular Communication & Diseases Cellular Stress Multiprotein Complexes and Disease

Lipid mediators are rapidly generated signaling molecules that translate membrane phospholipid metabolism into allergic inflammation. Following cell activation, phospholipase A2 releases arachidonic acid, which is converted through cyclooxygenase and lipoxygenase pathways into prostaglandins, thromboxanes, and leukotrienes. Mast cells are a major source after IgE-dependent activation, but eosinophils, platelets, epithelial cells, macrophages, and lymphocytes also synthesize or respond to these products. Unlike preformed histamine, lipid mediators are produced enzymatically and act through distinct G-protein-coupled receptors. Their short-range, context-dependent actions regulate vascular permeability, bronchial smooth-muscle tone, mucus secretion, leukocyte trafficking, and sensory responses, making them central to asthma, allergic rhinitis, urticaria, atopic disease, and anaphylactic reactions[1][2].

Cysteinyl leukotrienes LTC4, LTD4, and LTE4 are particularly potent. Generated through the 5-lipoxygenase pathway, they signal through CysLT1, CysLT2, and OXGR1-related receptor systems to produce bronchoconstriction and inflammation. Their function extends beyond the immediate effector phase: they can amplify type 2 immunity, influence dendritic and epithelial signals, and regulate innate and adaptive lymphocytes. Group 2 innate lymphoid cells respond to lipid cues as well as epithelial cytokines, enabling small cell populations to initiate or magnify allergic responses. Prostaglandins can be either activating or restraining depending on receptor, concentration, cell type, and timing. Thus, the lipid network is not uniformly proallergic; simultaneous production of opposing mediators helps determine whether inflammation expands, changes phenotype, or resolves. Additional receptor-selective agonists or antagonists could suppress harmful signals while preserving pro-resolving or protective lipid functions. Rational combinations may also target upstream type 2 cytokines, mast-cell activation, or downstream lipid receptors. Pharmacologic selectivity matters because a receptor can have different effects in airway smooth muscle, epithelium, vasculature, and immune cells, and blocking synthesis changes several downstream products at once[1][3][4][5].

This network also explains disease heterogeneity. The same allergen-specific IgE response can yield different clinical manifestations because tissue cells express different mediator receptors and metabolizing enzymes. Aspirin-exacerbated respiratory disease illustrates how perturbing cyclooxygenase metabolism can shift the balance toward leukotriene-dominant signaling. Environmental exposure, infection, epithelial damage, and cytokine context further alter mediator production and receptor expression. Modern analytical methods detect many lipid species released together, but abundance does not automatically establish biological dominance; sampling time is critical because production and degradation are rapid. Meaningful biomarkers should therefore link a mediator or metabolite to receptor engagement, cellular source, disease phase, and clinical response rather than treating a single plasma measurement as a stable signature. CysLT1 antagonists and the 5-lipoxygenase inhibitor zileuton reduce leukotriene signaling in selected allergic airway disorders, although responses vary and these agents do not replace emergency treatment for anaphylaxis[1][2][4][5].

Repeated sampling around allergen exposure or exacerbation may be more informative than a single baseline value and can reveal whether a drug shifts the balance toward resolution. Established therapies validate the pathway. Clinical trials should stratify patients by phenotype, mediator profile, aspirin sensitivity, and tissue compartment, and should measure symptoms and exacerbations alongside biochemical target engagement. A network-based view of lipid mediators clarifies why blockade of one branch helps some patients yet leaves parallel inflammatory circuits intact. Repeated sampling around exposure may clarify the mediator sequence[1][4][5].

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Cat. No. Product Name Information Application Publication
HY-17394 Cisplatin
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy.
DNA Alkylator/Crosslinker   Ferroptosis   Autophagy   Pyroptosis   Lipoxygenase  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Lung Squamous Cell Carcinoma   Large Cell Lung Carcinoma   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
837
HY-13419 U-73122
U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC.
Phospholipase   Lipoxygenase   Ferroptosis  
Inflammation or Immune System Disease   Prostate Cancer  
110
HY-L007 Immunology/Inflammation Compound Library
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 8,534 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Signaling Pathway Targeting Libraries

89
HY-L146 Metabolic Enzyme Compound Library
Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc. MCE designs a unique collection of 4,349 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.

Signaling Pathway Targeting Libraries

84
HY-L072 Exosomes Compound Library
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells in culture. Exosomes contain nucleic acids, proteins, lipids, amino acids, and metabolites, etc. Their diverse constituents can reflect their cell of origin. Exosomes are associated with immune responses, viral pathogenicity, pregnancy, cardiovascular diseases, central nervous system-related diseases, and cancer progression. Proteins, metabolites, and nucleic acids delivered by exosomes into recipient cells effectively alter their biological response. Such exosome-mediated responses can be disease promoting or restraining. The biology of exosomes in disease is still emerging, and the number of studies addressing their utility in the diagnosis and treatment of various pathologies has increased substantially. MCE supplies a unique collection of 56 compounds with the activity of inhibiting or stimulating exsomes secretion/biosynthesis. MCE Exosomes Compound Library is a useful tool for exsomes research.

Signaling Pathway Targeting Libraries

83
HY-L150 Membrane Receptor-targeted Compound Library
Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules. There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery. MCE provides a unique collection of 7,077 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

83
HY-L168 Extracellular Vesicles (EVs) Compound Library
Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells. MCE designs a unique collection of 696 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.

Signaling Pathway Targeting Libraries

83
HY-L228 Lipid Metabolite Compound Library
Lipids are important energy storage substances in the human body. They are involved in the regulation of cell structure and function, as well as signaling pathways and gene expression. Abnormal lipid levels in tissues or their dysregulation can lead to various diseases. These include obesity, type 2 diabetes, non-alcoholic fatty liver disease, neurodegenerative diseases, infections, and cancer. Therefore, maintaining normal levels of lipid metabolism is critical to overall health. One of the key features of cancer is aberrant lipid metabolism. This includes alterations in lipid uptake, lipid desaturation, neolipogenesis, lipid droplets, and fatty acid oxidation in cancer cells. These changes all contribute to cellular survival in an ever-changing microenvironment. They do this by modulating feed-forward oncogenic signals and key oncogenic functions. Additionally, they affect oxidative stress, other types of stress, immune responses, and intercellular communication. Alterations in lipid metabolism have a strong impact on the properties of cancer stem cells. This includes aspects such as self-renewal, differentiation, invasion, metastasis, drug sensitivity, and resistance. Furthermore, these alterations also modulate T cell responses. MCE can offer 148 metabolites of lipid metabolism pathways, which can be used for drug screening in cancer, immune-based diseases, metabolic diseases, and other diseases.

Metabolism Focused Libraries

83
HY-109590A Arachidonic acid sodium salt
Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function.

Source: mammalian cell

Endogenous Metabolite  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
60
HY-109590 Arachidonic acid
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function.

Source: mammalian cell

Endogenous Metabolite  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
60
HY-19989A MK-571 sodium
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.
P-glycoprotein   Leukotriene Receptor   LPL Receptor  
Inflammation or Immune System Disease   Ovarian Cancer   Lung Fibrosis  
36
HY-19989 MK-571
MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.
P-glycoprotein   Leukotriene Receptor   LPL Receptor  
Inflammation or Immune System Disease   Ovarian Cancer   Lung Fibrosis  
36
HY-N0142 Phloretin
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM，respectively.Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.
SGLT   Endogenous Metabolite   GLUT  
Cancer   Digestive System Disease   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
29
HY-N0551 Wedelolactone
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer.
Caspase   Lipoxygenase   Apoptosis  
Digestive System Disease   Prostate Cancer   Digestive System Inflammation  
25
HY-14164 Zileuton
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
Lipoxygenase   Ferroptosis  
Inflammation or Immune System Disease   Prostate Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
24
HY-108496 Sphingosine-1-phosphate
Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids. Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration.
Endogenous Metabolite   LPL Receptor  
Inflammation or Immune System Disease   Breast Cancer   Colorectal Cancer   Liver Cancer   Bladder Cancer   Ovarian Cancer  
21
HY-13315 Montelukast sodium
Montelukast sodium (MK0476) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast sodium decreases eosinophil infiltration into the asthmatic airways. Montelukast sodium can also be used for COVID-19 research.
Leukotriene Receptor  
Cancer   Inflammation or Immune System Disease   Viral Infection   SARS-CoV-2 Infection  
15
HY-13315A Montelukast
Montelukast (MK0476 free base) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast can be used for the reseach of asthma and liver injury. Montelukast also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast decreases eosinophil infiltration into the asthmatic airways. Montelukast can also be used for COVID-19 research.
Leukotriene Receptor  
Cancer   Inflammation or Immune System Disease   Viral Infection  
15
HY-14166 MK-886
MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.
FLAP   Leukotriene Receptor   PPAR   Apoptosis  
Cancer   Digestive System Disease   Digestive System Inflammation   Obesity  
14
HY-B0539 Desloratadine
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria.
Histamine Receptor   TNF Receptor   Leukotriene Receptor  
Prostate Cancer   Depression   Non-Small Cell Lung Cancer   SARS-CoV-2 Infection   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
14
HY-13516 Aloperine
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
Apoptosis   Autophagy   Filovirus   HIV  
Cancer   Digestive System Disease   Viral Infection   Digestive System Inflammation  
8
HY-12341 Onvoloxastat
Onvoloxastat (ML355) is an orally active selective 12-LOX inhibitor with an IC50 of 0.34 μM. Onvoloxastat inhibits platelet activation by blocking thrombin- or thromboxane A2-induced phosphorylation of Akt, PI3K and Erk1/2. At low doses (1-20 μM), it mainly acts by reducing ROS levels, while at high doses (50 μM), it functions via activating the cAMP pathway. Onvoloxastat can be used in research related to thrombosis and diabetes.
Lipoxygenase   Akt   PI3K   ERK   Reactive Oxygen Species (ROS)  
Cardiovascular Disease   Glucose Metabolism  
8
HY-N0198 Nordihydroguaiaretic acid
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
Lipoxygenase   Autophagy   Ferroptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Prostate Cancer   SARS-CoV-2 Infection  
8
HY-N0172 Caffeic acid
Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).
TRP Channel   Lipoxygenase   Endogenous Metabolite  
Inflammation or Immune System Disease   Prostate Cancer   Pain   SARS-CoV-2 Infection  
8
HY-107608 Leukotriene B4
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Endogenous Metabolite   PROTAC Linkers   Leukotriene Receptor  
Cancer   Inflammation or Immune System Disease  
7
HY-129555 Surfactin
Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects. Surfactin also has antiviral activity against a variety of enveloped viruses.

Source: Bacillus subtilis

Bacterial   HSV   Antibiotic  
Viral Infection   Bacterial Infection  
7
HY-N0232 Psoralidin
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.
COX   Lipoxygenase   Notch   Reactive Oxygen Species (ROS)   Bacterial  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Bacterial Infection   Depression   Rheumatoid Arthritis  
5
HY-N0573 Umbelliferone
Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.
Apoptosis   Fluorescent Dye  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
5
HY-W250978 Ovalbumins
Ovalbumins are the major proteins in egg white. Ovalbumins act as an allergen and inducer, and can be applied to mouse models of allergic diseases. Ovalbumins can induce allergic rhinitis in mice via sensitization and nasal challenge. Ovalbumins can be used to establish asthma models.
Ovalbumin, low endotoxin (HY-W250978A) is recommended for model establishment.
Interleukin Related   IFNAR  
Allergic Asthma   Allergic Rhinitis  
5
HY-N2259 Curcumenol
Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis.
Cytochrome P450   NF-κB   MMP   Interleukin Related   TNF Receptor   Akt   p38 MAPK   Ferroptosis   Apoptosis   CXCR   COX   Caspase   Bcl-2 Family   TGF-β Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Lung Cancer   Triple-Negative Breast Cancer   Osteoarthritis  
4
HY-111310 ML351
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D.
Lipoxygenase  
Glucose Metabolism   Parkinson's Disease  
4
HY-17492 Zafirlukast
Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
Leukotriene Receptor  
Cancer   Inflammation or Immune System Disease   Bacterial Infection  
4
HY-108568 15-Deoxy-Δ-12,14-prostaglandin J2
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
PPAR   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Alzheimer's Disease  
3
HY-B0290 Pranlukast
Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.
Leukotriene Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease  
3
HY-120973 Butaprost free acid
Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling.
Prostaglandin Receptor   TGF-beta/Smad  
Metabolic or Endocrine Disease  
2
HY-N0668 Rubusoside
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase).
GLUT   NF-κB   Amylases  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
2
HY-N0493 Pectolinarigenin
Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G2/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma.
COX   Lipoxygenase   NF-κB   p38 MAPK   ERK   HIF/HIF Prolyl-Hydroxylase   Keap1-Nrf2   PI3K   Apoptosis   Autophagy  
Colorectal Cancer   Prostate Cancer   Pancreatic Cancer   Neurodegenerative Disease   Rheumatoid Arthritis  
2
HY-N0656 Usnic acid
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase.
Bacterial   DNA/RNA Synthesis   Nuclear Factor of activated T Cells (NFAT)   Apoptosis  
Cancer   Digestive System Disease   Bacterial Infection   Digestive System Inflammation  
2
HY-13315S Montelukast-d6
Montelukast-d6 is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage.
Isotope-Labeled Compounds   Leukotriene Receptor  
Inflammation or Immune System Disease  
1
HY-13315S1 Montelukast-d6 sodium
Montelukast-d6 (sodium) is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage.
Leukotriene Receptor  
Inflammation or Immune System Disease  
1
HY-P4406A Abz-AGLA-Nba TFA
Abz-AGLA-Nba TFA is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba TFA is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal.
Fluorescent Dye  
1
HY-108568S 15-Deoxy-Δ-12,14-prostaglandin J2-d4
15-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
Isotope-Labeled Compounds   PPAR   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
1
HY-N4237 Saikogenin D
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.
Prostaglandin Receptor   Potassium Channel  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
1
HY-P4406 Abz-AGLA-Nba
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal.
Fluorescent Dye  
1
HY-P2203 SAHM1
SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice.
Notch  
Inflammation or Immune System Disease  
1
HY-NP159 House Dust Mite Extract, from D.farinae
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation.
Mucin   Interleukin Related  
Allergic Asthma  
1
HY-N0261 Aurantio-obtusin
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation.
TNF Receptor   COX  
Prostate Cancer   Depression   Hypertension   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-P990210 Anti-Mouse/Human IL-7 Antibody (M25)
Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for researches on inflammation conditions such as airway inflammation.

Species: Human/Mouse

Interleukin Related  
Inflammation or Immune System Disease  
1
HY-W012479 H-D-Trp-OH
H-D-Trp-OH (D-Tryptophan) is the D-isomer of tryptophan, which is occasionally found in natural peptides, such as marine toxin peptides. H-D-Trp-OH can increase intestinal microbial diversity and counteract the inhibitory effect of allergic airway inflammation on intestinal microbial diversity.
Endogenous Metabolite   Ligands for E3 Ligase  
Metabolic or Endocrine Disease  
1
HY-N0634 Cimifugin
Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS.
NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
1
HY-112248A HAMI 3379
HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation.
Leukotriene Receptor  
Inflammation or Immune System Disease   Cardiovascular Disease  
1
HY-D1056B3 Lipopolysaccharides, from Klebsiella pneumoniae
Lipopolysaccharides, from Klebsiella pneumoniae (LPS, from bacterial (Klebsiella pneumoniae)) are lipopolysaccharide endotoxins and TLR4 activators derived from Klebsiella pneumoniae, and are classified as S-type LPS. Lipopolysaccharides, from Klebsiella pneumoniae exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from Klebsiella pneumoniae may participate in bacterial immune evasion by inhibiting complement-mediated killing and suppressing the host's secretion of antimicrobial peptides, thereby allowing the bacteria to escape immune defenses. Lipopolysaccharides, from Klebsiella pneumoniae possess high viscosity and resistance to serum-mediated killing, which may lead to sepsis. Lipopolysaccharides, from Klebsiella pneumoniae can be used to construct Acute Lung Injury Model.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
1
HY-113053F Prostaglandin A1-biotin
Prostaglandin A1-biotin (PGA1-biotin) is a biotin-labeled Prostaglandin A1 (HY-113053). Prostaglandin A1-biotin can be found in the culture filtrate of rhizobia, and the culture filtrate containing this compound exhibits significant antiviral activity.
Drug Derivative  
Viral Infection  
/
HY-130440 Leukotriene F4
Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family. Leukotriene F4 induces bronchoconstriction with an ED50 of 16 μg/kg. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase.
Endogenous Metabolite   Leukotriene Receptor  
Inflammation or Immune System Disease  
/
HY-P992059 Anti-Mouse CD1d Antibody (1B1)
Anti-Mouse CD1d Antibody (1B1) is an antibody targeting mouse CD1d (Kd=12.5 nM). By inserting into the lipid-binding groove of CD1d, Anti-Mouse CD1d Antibody (1B1) overlaps with the binding sites of type I and type II NKT cell receptors (TCR), thereby effectively blocking TCR-mediated interactions. Anti-Mouse CD1d Antibody (1B1) activates antigen-presenting cells such as dendritic cells and macrophages, induces them to release IL-12p70, and increases the levels of key cytokines including IL-12, IFN-γ and IFN-α in mouse serum. Anti-Mouse CD1d Antibody (1B1) can be used in studies related to renal cancer, breast cancer and colon adenocarcinoma. When combined with anti-DR5 or anti-CD137 antibodies and chemotherapeutic drugs, Anti-Mouse CD1d Antibody (1B1) exhibits significant tumor inhibitory and even eradication effects in mice.

Species: Mouse

CD1  
Cancer  
/
HY-D3303 8-iso Prostaglandin A2-biotin
8-iso Prostaglandin A2-biotin (8-iso PGA2-biotin) is an affinity probe conjugated with biotin, consisting of 8-iso Prostaglandin A2 (8-iso PGA2). 8-iso PGA2 is an isoprostaglandane produced by the radical-catalyzed peroxidation of arachidonic acid. 8-iso Prostaglandin A2-biotin can be detected by its interaction with a biotin ligand.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-12292G IM-12 (GMP)
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca2+ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABLT315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia.
NF-κB   STAT   GSK-3   β-catenin   Bcr-Abl  
Leukemia/Lymphoma/Myeloma  
/
HY-N7833 Heneicosapentaenoic acid
Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.
Biochemical Assay Reagents  
/
HY-NP229 DNP-BSA
DNP-BSA is a multivalent antigen and protein-binding reagent. DNP-BSA binds to subdomain IIA (Site I) of bovine serum albumin via predominantly hydrophobic forces, with spontaneous complex formation via combined dynamic and static quenching. DNP-BSA induces cross-linking of IgE-bound FceRI, triggering tyrosine phosphorylation of FceRI β and γ subunits. DNP-BSA binds to anti-DNP IgE via its DNP groups, forming cross-links between IgE-FceRI complexes, with most DNP groups initially unavailable but transiently exposed for binding. DNP-BSA induces FITC fluorescence quenching in FITC-labeled anti-DNP IgE, proportional to occupied IgE Fab binding sites. DNP-BSA can be used for the research of allergy, inflammation, and contact sensitivity (allergic contact dermatitis).
Biochemical Assay Reagents  
Allergy  
/
HY-131384 8,11,14-Eicosatriynoic acid
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
COX  
/
HY-129953F Prostaglandin F2α-biotin
Prostaglandin F2α-biotin (PGF2α-biotin) is a biotinylated form of Prostaglandin F2α (HY-12956). Prostaglandin F2α-biotin can be used in the study of the mechanism of action of prostaglandins. In addition, Prostaglandin F2α-biotin can be detected in the ethanolic extract of Hawm Gra Dang Ngah rice.
Biochemical Assay Reagents   Prostaglandin Receptor  
/
HY-P11646 Brazzein
Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.
Brazzein inhibits COX-2 with an IC50 of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 μM). Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation.
Free Radical Scavengers   COX  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-112005G DOPE (GMP)
DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.
Ferroptosis   Glutathione Peroxidase   ACSL Family   Amino acid Transporter  
Digestive System Disease   Alzheimer's Disease   Colitis  
/
HY-B0131S2 Prostaglandin E1-d9
Prostaglandin E1-d9 is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh
Isotope-Labeled Compounds   Prostaglandin Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W654296 Octocrylene-13C3
Octocrylene-13C3 is the 13C-labeled Octocrylene (HY-A0087). Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes.
Isotope-Labeled Compounds   Biochemical Assay Reagents   Cytochrome P450   PPAR   Estrogen Receptor/ERR  
/
HY-116028S1 15-deoxy-Δ12,14-Prostaglandin D2-d4
15-Deoxy-Δ12,14-Prostaglandin D2-d4 (15-Deoxy-Δ12,14-PGD2-d4) is the deuterium labeled 15-deoxy-Δ12,14-Prostaglandin D2. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is a metabolite of prostaglandin D₂ (PGD₂) (HY-101988), which can undergo further dehydration metabolism to 15-deoxy-Δ12,14-PGJ₂. 15-deoxy-Δ12,14-Prostaglandin D2 is a highly selective agonist for DP2 receptor and PPARγ. 15-deoxy-Δ12,14-Prostaglandin D2 causes morphological changes in eosinophils and migration of type II innate lymphoid cells (ILC2). 15-deoxy-Δ12,14-Prostaglandin D2 has a growth inhibitory effect on prostate cancer cells expressing PPARγ, induces cell cycle arrest and promotes apoptosis. 15-deoxy-Δ12,14-Prostaglandin D2 can be used in related research on asthma and prostate cancer.
Isotope-Labeled Compounds   Endogenous Metabolite   Prostaglandin Receptor   PPAR   Src  
Cancer   Inflammation or Immune System Disease  
/
HY-175142 Prostaglandin E2-PEG11-biotin
Prostaglandin E2-PEG11-biotin is a ligand. Prostaglandin E2-PEG11-biotin can be immobilized on flow cells. The immobilized Prostaglandin E2-PEG11-biotin binds to BtOCT1. Prostaglandin E2-PEG11-biotin can be used in SPR.
Biochemical Assay Reagents  
/
HY-175131 Prostaglandin D2-biotin
Prostaglandin D2-biotin is a fluorescent probe that can be used for detecting PGD2.
Fluorescent Dye  
/
HY-P3600 FIZZ-1 (32-51) (mouse)
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia.
Apoptosis  
Inflammation or Immune System Disease  
/
HY-P0205A Saralasin acetate hydrate
Saralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
Angiotensin Receptor  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P4971 C5a Anaphylatoxin (human)
C5a Anaphylatoxin (human) is a pro-inflammatory peptide and a leukocyte chemoattractant. C5a Anaphylatoxin (human) can be used to study inflammation and immunity, such as allergic asthma.
Complement System  
Inflammation or Immune System Disease  
/
HY-120665 Prostaglandin B1
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand.

Source: Hunian semen

Prostaglandin Receptor  
Metabolic or Endocrine Disease  
/
HY-P992349 DXL625
DXL625 is an autophilic CD20-targeting agent. DXL625 triggers downstream apoptosis signaling pathways dependent on intact lipid rafts and extracellular Ca2+. DXL625 induces caspase-mediated apoptosis in cancer cells and selectively targets cells in the actively proliferative S phase. DXL625 mediates complement-dependent cytotoxicity in cancer cells and primary B lymphocytes. DXL625 can be used in research related to Burkitt's lymphoma and B-cell lymphoma.

Species: Human

CD20   Apoptosis  
Leukemia/Lymphoma/Myeloma  
/
HY-113459S Prostaglandin F1a-d9
Prostaglandin F1a-d9 is the deuterium labeled Prostaglandin F1a. Prostaglandin F1a is an endogenous metabolite and a cyclooxygenase product with platelet activity inhibitory effects. Prostaglandin F1a can be used as a marker in coagulation-related studies.
Isotope-Labeled Compounds   COX   Prostaglandin Receptor   Endogenous Metabolite  
/
HY-P10854 TAT-N15
TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke.
NF-κB   Akt   STAT   Interleukin Related  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P0193 Nocistatin (Bovine)
Nocistatin (Bovine) is a nociceptin precursor contains another biologically active peptide. Nocistatin (Bovine) blocks nociception-induced allodynia and hyperalgesia. Nocistatin (Bovine) also attenuates pain evoked by prostaglandin E2. Nocistatin (Bovine) can bind to the membrane of mouse brain and spinal cord with high affinity. Nocistatin (Bovine) can be studied in research on pain transmission.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-109590S4 Arachidonic acid-13C5
Arachidonic acid-13C5 (Immunocytophyt-13C5) is the 13C-labeled Arachidonic acid (HY-109590). Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-P1020 Nocistatin(human)
Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
Prostaglandin Receptor  
Neurological, Eye or Ear Disease  
/
HY-113887S Prostaglandin F1β-d9
Prostaglandin F1β-d9 is deuterium labeled Prostaglandin F1β.
Isotope-Labeled Compounds  
/
HY-N1964B Gibberellic acid Sterile Solution (1 mg/ml)
Gibberellic acid Sterile Solution (1 mg/mL) (GA3 Sterile Solution (1 mg/mL)) is a natural plant growth regulator with oral bioactivity. Gibberellic acid Sterile Solution (1 mg/mL) governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid Sterile Solution (1 mg/mL) optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid Sterile Solution (1 mg/mL) mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid Sterile Solution (1 mg/mL) can be used in studies of plant growth, metabolism, and abiotic stress responses.
Plant Growth Regulators   Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-113042S Prostaglandin B2-d4
Prostaglandin B2-d4 is the deuterium labeled Prostaglandin B2.
Isotope-Labeled Compounds  
/
HY-163552 Prostaglandin F2a/BSA
Prostaglandin F2a/BSA is an antigen-adjuvant conjugate formed by the conjugation of Prostaglandin F2a with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes and can enhance cross-presentation as well as the generation of antigen-specific T cells.
Prostaglandin Receptor  
Inflammation or Immune System Disease  
/
HY-P12011 MTS peptide
MTS peptide is a short peptide with a mitochondria-targeting sequence. In F-M-LNP, MTS peptide is displayed on the particle surface via thiol-maleimide conjugation, and is specifically responsible for being recognized by the mitochondrial proteins TOMM20/22, "anchoring" the nanoparticles to the outer mitochondrial membrane, followed by membrane potential-independent bilayer membrane penetration mediated by fluorinated lipids. MTS peptide can be used in the research of Leber's hereditary optic neuropathy.
Mitochondrial Metabolism  
Visual System Disease  
/
HY-139952S Prostaglandin D2 Dopamine-d4
Prostaglandin D2 Dopamine-d4 is the deuterium labeled Prostaglandin D2 Dopamine.
Isotope-Labeled Compounds  
/
HY-N1964A Gibberellic acid, suitable for plant cell culture
Gibberellic acid, suitable for plant cell culture (GA3, suitable for plant cell culture) is a natural plant growth regulator with oral bioactivity. Gibberellic acid, suitable for plant cell culture governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid, suitable for plant cell culture optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid, suitable for plant cell culture mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid, suitable for plant cell culture can be used in studies of plant growth, metabolism, and abiotic stress responses.
Plant Growth Regulators   Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-W777393 Umbelliferone-13C6
Umbelliferone-13C6 (7-Hydroxycoumarin-13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.
Isotope-Labeled Compounds   Fluorescent Dye   Apoptosis  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P991467 RG-7258
RG-7258 is a human monoclonal antibody (mAb) targeting CRLF2. RG-7258 blocks dendritic cell activation and mast cell cytokine release. RG-7258 reduces Th2 inflammation in a non-human primate model of allergic lung inflammation. RG-7258 can be used in asthma research.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-125150 AL-3138
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production.
Prostaglandin Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-116015 Dihomo-γ-Linolenic acid methyl ester
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects.
Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-P1111A Lyn peptide inhibitor TFA
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of  asthma, allergic, and other eosinophilic disorders.
Src   Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P1020A Nocistatin(human) TFA
Nocistatin (human) TFA blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
Prostaglandin Receptor  
Neurological, Eye or Ear Disease  
/
HY-W009300S1 4-Hydroxyestrone-13C6
4-Hydroxyestrone (4-OHE1)-13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
Isotope-Labeled Compounds   Endogenous Metabolite   Estrogen Receptor/ERR   Sirtuin   MDM-2/p53   PDI   Ferroptosis   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-A0024S Tolterodine-d14 hydrochloride
Tolterodine-d14 (hydrochloride) is the deuterium labeled Tolterodine hydrochloride. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.
Isotope-Labeled Compounds   mAChR   Cytochrome P450  
Neurological, Eye or Ear Disease  
/
HY-P10457 15-Hydroxy prostaglandin dehydrogenase blocking peptide
5-Hydroxy prostaglandin dehydrogenase blocking peptide (15-PGDH (92-105)) is a blocking peptide that corresponds to the amino acids (AGVNNEKNWEKTLQ) located at positions 92-105 of the 15-hydroxy prostaglandin dehydrogenase (15-PGDH) sequence. 5-Hydroxy prostaglandin dehydrogenase blocking peptide can block the formation of protein-antibody complexes during immunohistochemical analysis of 15-PGDH.
15-PGDH  
/
HY-W127501 Prostaglandin G1
Prostaglandin G1 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Biochemical Assay Reagents  
/
HY-113041S Prostaglandin A2-d4
Prostaglandin A2-d4 is the deuterium labeled Prostaglandin A2.
Isotope-Labeled Compounds  
/
HY-113366S Prostaglandin J2-d4
Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2.
Isotope-Labeled Compounds  
/
HY-B0580S2 Ketorolac-13C6
Ketorolac-13C6 (RS37619-13C6) is 13C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research.
Isotope-Labeled Compounds   COX   Apoptosis  
Inflammation or Immune System Disease  
/
HY-B0852S2 Tebuconazole-d6
Tebuconazole-d6 is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
Isotope-Labeled Compounds   Fungal   Cytochrome P450  
Infection  
/
HY-P2027 B 4310
B 4310 is a non-organ-selective Bradykinin antagonist. B 4310 induces uterine contraction in rats. B 4310 blocks bradykinin-mediated responses, including substance P release, plasma extravasation, venous contraction, prostaglandin E2 release and trigeminal nerve stimulation, but exerts no effect on angiotensin II, acetylcholine or capsaicin pathways. B 4310 exerts a reversible antagonistic effect on bradykinin-induced nociceptors. B 4310 serves as a tool for investigating the biological effects of bradykinin.
Bradykinin Receptor  
Female Reproductive System Disease   Hypotension  
/
HY-90010S Tolterodine tartrate-d14
Tolterodine tartrate-d14 (Kabi-2234-d14) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.
Isotope-Labeled Compounds   mAChR   Cytochrome P450  
Cancer   Neurological, Eye or Ear Disease  
/
HY-114826S Prostaglandin E2-1-glyceryl ester-d5
Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceyl ester-d5) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
Isotope-Labeled Compounds   Cannabinoid Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-138166S Rosuvastatin lactone-d6
Rosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.
Isotope-Labeled Compounds   NO Synthase   Drug Metabolite   Potassium Channel  
Blood or Cardio-cerebrovascular Disease  
/
HY-119684S Maresin 2
Maresin 2-d5 is the d5-labeled Maresin 2 (HY-119684). Maresin 2 is an anti-inflammatory and pro-resolving mediator. Maresin 2 drives intestinal epithelial cell migration by activating the focal cell-matrix adhesion signaling pathway in primary human intestinal epithelial cells, thereby promoting mucosal wound repair. Maresin 2 alleviates nociceptive and anxiety-like behaviors in rats with type 1 diabetes by inhibiting IL-1β in the spinal cord and prefrontal cortex. Maresin 2 attenuates allergic airway inflammation in mice by inhibiting the activation of the NLRP3 inflammasome, Th2-type immune responses, and oxidative stress. Maresin 2 inhibits inflammatory and neuropathic trigeminal neuralgia and reduces neuronal activation in the trigeminal ganglion. Maresin 2 promotes inflammation resolution and mucosal repair after DSS-induced colitis or biopsy-induced colonic mucosal injury.
Isotope-Labeled Compounds   NOD-like Receptor (NLR)   Interleukin Related  
Digestive System Disease   Anxiety or Fear-Related Disease   Pain   Colitis  
/
HY-151994S 1,3-Diolein-d66
1,3-Diolein-d66 is deuterium labeled 1,3-Diolein. 1,3-Diolein is a phospholipid compound that has the activity of regulating cell membrane fluidity and signal transduction. 1,3-Diolein is widely used in cell biology research to study lipid-mediated signal transduction pathways and membrane protein interactions. 1,3-Diolein can also serve as a functional carrier in compound delivery systems to help improve the bioavailability of compounds.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-D3313 15-Deoxy-Δ12,14-Prostaglandin J2-biotin
15-Deoxy-Δ12,14-Prostaglandin J2-biotin is a biotin-labled 15-Deoxy-Δ12,14-Prostaglandin J2 (HY-108568). 15-Deoxy-Δ12,14-Prostaglandin J2-biotin is a biotin can be used as a fluorescent probe.
Fluorescent Dye   Drug Derivative  
/
HY-P990122 Anti-Rat IL-4 Antibody (OX-81)
Anti-Rat IL-4 Antibody (OX-81) is an antibody inhibitor against rat IL-4. Anti-Rat IL-4 Antibody (OX-81) can specifically block the anti-inflammatory effect of IL-4. Anti-Rat IL-4 Antibody (OX-81) can be used for research on inflammation conditions such as experimental allergic encephalomyelitis (EAE).

Species: Rat

Interleukin Related  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-P990207 Anti-Mouse/Human Integrin β7 Antibody (FIB504)
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7 IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma.

Species: Human/Mouse

Integrin  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P990264 Anti-Mouse CD70 Antibody (FR70)
Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4+, CD8+ T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models.

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-113456S Leukotriene D4-d5
Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
Drug Metabolite   Endogenous Metabolite  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-N3535 Canniprene
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; IC50=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins.
Prostaglandin Receptor   Lipoxygenase  
Inflammation or Immune System Disease  
/
HY-N10225 Thielavin A
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration.

Source: Thielavia Terricola

Prostaglandin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P991278 ABM-125
ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations.

Species: Human

Interleukin Related  
Asthma  
/
HY-P991736 Anti-IL11 Antibody (X203, Mouse IgG)
Anti-IL11 Antibody (X203, Mouse IgG) is an antibody targeting IL-11. Anti-IL11 Antibody (X203, Mouse IgG) inhibits IL-11-mediated activation of the ERK-mTORC1 axis, inactivation of LKB1-AMPK, and pro-senescence pathways. Anti-IL11 Antibody (X203, Mouse IgG) alleviates age-related metabolic decline, improves muscle function, reduces tissue fibrosis, decreases the expression of senescence markers, and maintains telomere length and mtDNA copy number. Anti-IL11 Antibody (X203, Mouse IgG) restores browning of white adipose tissue, upregulates thermogenic and mitochondrial biogenesis gene programs, reduces lipid droplet size, and decreases immune cell infiltration in visceral white adipose tissue. Anti-IL11 Antibody (X203, Mouse IgG) extends the median lifespan of mice and reduces the incidence of age-related tumors. Anti-IL11 Antibody (X203, Mouse IgG) can be used in the research of age-related metabolic decline, sarcopenia and age-related cancers.

Species: Human

Interleukin Related   ERK   mTOR   AMPK  
Cancer   Inflammation or Immune System Disease  
/
HY-113465S Leukotriene E4-d5
Leukotriene E4-d5 (LTE4-d5) is the d-5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases.
Isotope-Labeled Compounds   Endogenous Metabolite   Leukotriene Receptor   Calcium Channel   ERK   P2Y Receptor  
Asthma  
/
HY-P990175 Anti-Mouse OX40L/CD134L Antibody (RM134L)
Anti-Mouse OX40L/CD134L Antibody (RM134L) is an anti-mouse OX40L/CD134L IgG2b monoclonal antibody. Anti-Mouse OX40L/CD134L Antibody (RM134L) reduces immune response by inhibiting the OX40/OX40L signaling pathway. Anti-Mouse OX40L/CD134L Antibody (RM134L) can inhibit plasma cell differentiation and antibody secretion. Anti-Mouse OX40L/CD134L Antibody (RM134L) can prolong the survival time of cell transplantation by inhibiting CD4+ T cells. Anti-Mouse OX40L/CD134L Antibody (RM134L) can be used for researches on inflammation and cancer such as graft versus host disease (GVHD), allergic reaction, lupus nephritis and hepatocellular carcinoma (HCC).

Species: Mouse

Orexin Receptor (OX Receptor)  
Cancer   Inflammation or Immune System Disease  
/
HY-P991911 PLT012
PLT012 is a humanized IgG4 antibody targeting CD36. PLT012 inhibits the lipid-binding domain of CD36. PLT012 blocks CD36-mediated metabolic adaptation in regulatory T cells (Tregs) and CD8+ tumor-infiltrating lymphocytes (TILs), thereby inhibiting tumor growth and shifting the tumor microenvironment from immunosuppressive to immunosupportive. PLT012 reduces intratumoral Tregs, enhances CD8+ T cell infiltration and cytotoxic function, and increases the abundance of progenitor-exhausted T cells. PLT012 exerts robust antitumor activity and synergizes with anti-PD-L1 or standard-of-care regimens (anti-VEGF + anti-PD-L1). PLT012 can be used for hepatocellular carcinoma, colorectal cancer and solid tumor research.

Species: Human

Scavenger Receptor Class B type I (SR-BI）  
Colorectal Cancer   Hepatitis B Virus Related Hepatocellular Carcinoma  
/
HY-W009300S 4-Hydroxyestrone-d4
4-Hydroxyestrone (4-OHE1)-d4 is the deuterium labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
Endogenous Metabolite   Isotope-Labeled Compounds   Estrogen Receptor/ERR   Sirtuin   MDM-2/p53   PDI   Ferroptosis   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P991266 SM-17
SM-17 is a human monoclonal antibody targeting IL-17RB. SM-17 binds to human IL-17RB, inhibits the dimerization of IL-17RA/IL-17RB, blocks IL-25-induced phosphorylation of ERK1/2 and STAT5, and suppresses Th2-mediated inflammatory responses. SM-17 inhibits the secretion of IL-5, IL-9, IL-13 and IL-4, impairs the proliferation/expansion of ILC2 and Th2 cells, and restores filaggrin expression. SM-17 reduces immune cell infiltration, epidermal hyperplasia, goblet cell hyperplasia, collagen deposition, ear swelling and scratching behavior in animal models. SM-17 can be used in research related to atopic dermatitis and allergic asthma.

Species: Human

Interleukin Related   ERK   STAT  
Allergic Asthma   Atopic Dermatitis  
/
HY-W011927R 4,4'-Sulfonyldiphenol (Standard)
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
Reference Standards   Estrogen Receptor/ERR   Histone Methyltransferase   Thyroid Hormone Receptor   PI3K   Akt   mTOR   Androgen Receptor   Drug Derivative  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N0573S Umbelliferone-d5
Umbelliferone-d5 (7-Hydroxycoumarin-d5) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.
Isotope-Labeled Compounds   Apoptosis   Fluorescent Dye  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-113053 Prostaglandin A1
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis.

Source: Human semen

Endogenous Metabolite   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N10319 Artepillin C
Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 μM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce necroptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation.
Epigenetic Reader Domain   Necroptosis   TRP Channel  
Digestive System Disease   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pain   Digestive System Inflammation   Glucose Metabolism   Obesity  
/
HY-N0081 (±)-Praeruptorin A
(±)-Praeruptorin A, a coumarin compound, is the main bioactive component in Peucedani Radix. As a calcium channel blocker, (±)-Praeruptorin A exhibits great antihypertensive effects. In addition, (±)-Praeruptorin A also has the effects of relaxing vascular smooth muscle, inhibiting airway inflammation and airway hyperresponsiveness. (±)-Praeruptorin A can be used for the research of allergic asthma, hypertension and other diseases.
Calcium Channel   NF-κB   Interleukin Related  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Hypertension   Obesity   Rheumatoid Arthritis  
/
HY-113505 Delta-12-Prostaglandin J2
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation.
Endogenous Metabolite   Apoptosis  
Cancer  
/
HY-113446S Leukotriene C4-d5
Leukotriene C4-d5 is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.
Endogenous Metabolite   Isotope-Labeled Compounds  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P990208 Anti-Mouse IL-9 Antibody (9C1)
Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody. Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF-κB signaling pathway and decrease the infiltration of inflammatory cells. Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects. Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation, infection conditions and cancer such as parasitic infections, allergic reactions, breast cancer and osteosarcoma.

Species: Mouse

Interleukin Related   NF-κB   Parasite  
Infection   Inflammation or Immune System Disease   Breast Cancer  
/
HY-108496S Sphingosine-1-phosphate-d7
Sphingosine-1-phosphate-d7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12.?Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids.
Endogenous Metabolite   LPL Receptor  
Metabolic or Endocrine Disease  
/
HY-P3982 CKLF1-C19
CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4.
CCR  
Inflammation or Immune System Disease  
/
HY-NP159A House Dust Mite Extract, from D.pteronyssinus
House Dust Mite Extract, from D. pteronyssinus is a house dust mite allergenic extract derived from Dermatophagoides pteronyssinus. House Dust Mite Extract, from D. pteronyssinus increases serum IgE, IgG1 and IgG2a levels, and elevates the levels of Interleukins 4, 5, 6, 10, 13 and 17. House Dust Mite Extract, from D. pteronyssinus induces significant asthmatic pathological changes. House Dust Mite Extract, from D. pteronyssinus can be used in studies related to asthma and allergic conjunctivitis.
Interleukin Related  
Allergic Asthma  
/
HY-P990260 Anti-Mouse CD86/B7-2 Antibody (GL-1)
Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation.

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-153235 COVID-19 Spike Protein mRNA-LNP
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing mRNA encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2.
mRNA   SARS-CoV   Liposome  
Infection  
/
HY-P0205 Saralasin
Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
Angiotensin Receptor  
Inflammation or Immune System Disease   Prostate Cancer   Hypertension  
/
HY-148978 18:0,18:1 PS sodium
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage.
Exosomes   Endogenous Metabolite   Liposome  
Metabolic or Endocrine Disease  
/
HY-N15135 Arabinoxylan (Medium viscosity)
Arabinoxylan Medium viscosity is an orally active Dectin-1 splice variant modulator, glucose absorption inhibitor, and chyme viscosity enhancer. Arabinoxylan Medium viscosity inhibits particulate β-glucan-induced Dectin-1A activation and mildly suppresses Dectin-1B activation. In human dendritic cells stimulated with particulate β-glucan, Arabinoxylan Medium viscosity reduces the production of IL-10 and TNF-α, and increases the production of IL-4 and IL-23. Arabinoxylan Medium viscosity also supports antifungal immune responses without activating TLR2, TLR4 or TLR5, and does not induce cytokine production when used to stimulate human dendritic cells alone. Arabinoxylan Medium viscosity increases small intestinal chyme viscosity, gets degraded in the large intestine to produce short-chain fatty acids, reduces glucose absorption and insulin response, and improves glucose homeostasis. Arabinoxylan Medium viscosity supports microbial fermentation and the growth of beneficial microbiota in the gastrointestinal tract, prevents bile acid reabsorption, and delays starch digestion. Arabinoxylan Medium viscosity can be used in research related to type 2 diabetes, impaired glucose tolerance, and metabolic syndrome.
Interleukin Related   Toll-like Receptor (TLR)   Fungal   C-type Lectin-like Receptors (CTLRs)  
Glucose Metabolism  
/
HY-D0053 6-ROX
6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2.
Fluorescent Dye  
/
HY-113366 Prostaglandin J2
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD).
Prostaglandin Receptor   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-113446 Leukotriene C4
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage.
Endogenous Metabolite  
Chronic Obstructive Pulmonary Disease   Asthma   Atherosclerosis  
/
HY-128900 11-cis-Vaccenyl acetate
11-cis-Vaccenyl acetate is male-specific lipid that mediates aggregation behavior in both male and female flies, which activates a few dozen olfactory neurons located in T1 sensilla on the antenna of both male and female flies.
Endogenous Metabolite  
/
HY-P0205B Saralasin TFA
Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an octapeptide analog of angiotensin II. Saralasin TFA is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin TFA can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
Angiotensin Receptor  
Inflammation or Immune System Disease   Prostate Cancer   Hypertension  
/
HY-N1193 Sulfuretin
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM.
NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Glucose Metabolism   Parkinson's Disease   Obesity  
/
HY-P990150 Anti-Mouse TSLP Antibody (28F12)
Anti-Mouse TSLP Antibody (28F12) is an anti-mouse TSLP IgG2a monoclonal antibody. Anti-Mouse TSLP Antibody (28F12) weakens skin inflammation and allergic reactions by reducing Treg cells and lymph node cells. Anti-Mouse TSLP Antibody (28F12) can be used for research on allergic conditions.

Species: Mouse

Interleukin Related  
Allergy  
/
HY-101952G Prostaglandin E2 (GMP)
Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions.
Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-115864 Osavampator
Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders.
iGluR   Lipoxygenase  
Neurological, Eye or Ear Disease  
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HY-W011927 4,4'-Sulfonyldiphenol
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
Estrogen Receptor/ERR   Histone Methyltransferase   Thyroid Hormone Receptor   PI3K   Akt   mTOR   Androgen Receptor   Drug Derivative  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease  
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Keywords

lipid mediators | allergic inflammation | cysteinyl leukotrienes | prostaglandins | ILC2 | type 2 immunity