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Ubiquitination and autophagy regulate host-pathogen interactions

Proteostasis Cellular Stress Multiprotein Complexes and Disease Chronic Inflammation

Ubiquitination and autophagy form a connected surveillance system that recognizes intracellular pathogens, directs them toward destruction, and calibrates inflammation. Ubiquitin can mark invading bacteria, damaged pathogen-containing vacuoles, viral proteins, or host signaling components. Selective autophagy receptors then bind ubiquitin and LC3-family proteins to enclose cargo in autophagosomes for lysosomal degradation, a process often termed xenophagy. Pathogens have evolved effectors that remove ubiquitin, block receptor recruitment, prevent autophagosome maturation, or exploit autophagic membranes. The outcome therefore reflects a molecular arms race in which the same machinery controls microbial restriction, antigen processing, inflammatory signaling, and host-cell survival The pathway was initially understood as a homeostatic recycling system, but infection biology revealed that it can act with remarkable cargo selectivity[1][2][3].

E1, E2, and E3 enzymes assemble ubiquitin chains with linkage patterns that encode degradation or signaling instructions. On cytosolic microbes, receptors such as p62, NDP52, and optineurin connect these tags to the autophagy machinery; phosphorylation by TBK1 can strengthen cargo recognition. Autophagy also removes damaged mitochondria and inflammasome-activating material, limiting excessive cytokine release. Salmonella provides a well-studied example in which vacuolar damage exposes bacteria to ubiquitin and selective autophagy, while bacterial factors manipulate both processes. Viral and bacterial pathogens may redirect host ubiquitin ligases or deubiquitinases to destabilize immune proteins and escape innate sensing Different ubiquitin-chain architectures recruit distinct readers, allowing the host to encode localization, signaling, and degradation within one conserved post-translational modifier[1][2][3].

Disease applications extend from acute infection to chronic inflammation and antimicrobial drug discovery. Enhancing xenophagy could help clear pathogens that persist inside macrophages or epithelial cells, whereas reducing harmful autophagy may be useful when a pathogen exploits the pathway for replication. Modulating ubiquitin enzymes can restore interferon or inflammatory signaling, but broad proteasome or autophagy intervention affects essential host functions. Genetic defects in autophagy or ubiquitin recognition can alter infection susceptibility and inflammatory disease. Therapeutic design must therefore identify a pathogen-specific effector, host enzyme dependency, or transient intervention window rather than globally turning autophagy “on” or “off” Autophagy can also influence presentation of microbial antigens and the survival of infected cells, adding adaptive immunity and tissue integrity to the outcome[1][3].

Research gaps include linkage-specific detection in infected tissue, cell-type differences, and limited translation from transformed cell lines. Proteomics and proximity labeling can identify host–pathogen ubiquitin networks, while live imaging can show whether tagged cargo reaches a functional lysosome. Organoids and primary immune cells are needed to preserve tissue-specific metabolism and signaling. Candidate drugs should be tested for microbial clearance, inflammatory injury, and host-cell viability together. Resistance may arise because pathogens carry multiple effectors targeting the same pathway. Ubiquitination and autophagy are promising therapeutic nodes precisely because they integrate recognition and disposal, but that centrality also makes untargeted manipulation hazardous A useful therapeutic study must specify whether benefit comes from direct pathogen destruction, restored innate signaling, reduced inflammatory damage, or a combination of these effects. Therapeutic studies should also test whether manipulating a host pathway changes pathogen evolution or selects escape variants that retain virulence while avoiding the engineered surveillance mechanism[1][2][3].

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Cat. No. Product Name Information Application Publication
HY-13259 MG-132
MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.
Proteasome   Autophagy   Apoptosis  
Cancer  
2269
HY-10219 Rapamycin
Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

Source: Streptomyces hygroscopicus

mTOR   FKBP   Molecular Glues   Fungal   Autophagy   Endogenous Metabolite   Antibiotic   Bacterial  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Fungal Infection   Pain   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   SARS-CoV-2 Infection   Obesity   Lung Fibrosis  
1475
HY-17589A Chloroquine
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
Parasite   Autophagy   SARS-CoV   Toll-like Receptor (TLR)   HIV   Antibiotic  
Breast Cancer   Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   SARS-CoV-2 Infection   Rheumatoid Arthritis  
1351
HY-100558 Bafilomycin A1
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

Source: Streptomyces griseus strains

Proton Pump   Autophagy   Antibiotic   Bacterial   Apoptosis  
Infection  
915
HY-17394 Cisplatin
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy.
DNA Alkylator/Crosslinker   Ferroptosis   Autophagy   Pyroptosis   Lipoxygenase  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Lung Squamous Cell Carcinoma   Large Cell Lung Carcinoma   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
862
HY-15142 Doxorubicin hydrochloride
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

Source: Streptomyces peucetius var. Caesius

Topoisomerase   ADC Payloads   AMPK   Autophagy   Apoptosis   HIV   HBV   Mitophagy   Antibiotic   Bacterial   Fluorescent Dye  
Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
713
HY-10071 Y-27632
Y-27632 is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.
ROCK   Reactive Oxygen Species (ROS)   Akt   Ras   mTOR   Apoptosis   PAK   NADPH Oxidase   NF-κB   Autophagy  
Cancer   Digestive System Disease   Digestive System Inflammation   Lung Fibrosis  
607
HY-100218A RSL3
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.
p62   Glutathione Peroxidase   Ferroptosis   Reactive Oxygen Species (ROS)  
Ovarian Cancer  
575
HY-13453 BAY 11-7082
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
IKK   Deubiquitinase   Autophagy   Apoptosis   NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
510
HY-14648 Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.
Exosomes   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic   ADC Payloads  
Metabolic or Endocrine Disease   Prostate Cancer   Pancreatic Cancer   Viral Infection   Bacterial Infection   Fungal Infection   Pain   Autoimmune Disease   Digestive System Inflammation   Cardiovascular Disease   Non-Small Cell Lung Cancer   Lung Squamous Cell Carcinoma   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
403
HY-13757A Tamoxifen
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).
Estrogen Receptor/ERR   HSP   Autophagy   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Digestive System Disease   Prostate Cancer   Viral Infection   Digestive System Inflammation   Luminal Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
273
HY-15371 Forskolin
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
Organoid   Adenylate Cyclase   FXR   Autophagy   PKC  
Glucose Metabolism   Non-Small Cell Lung Cancer   Hypertension  
233
HY-13417 AICAR
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity.
AMPK   Autophagy   YAP   Mitophagy   Endogenous Metabolite  
Cancer  
231
HY-K0208 Streptavidin Magnetic Beads

MCE Streptavidin Magnetic Beads provide a fast and convenient method for numerous applications, including purification of proteins and nucleic acids, protein interaction studies, immunoprecipitation, immunoassays, pull-down and cell isolation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Purification Magnetic Beads

228
HY-16561 Resveratrol
Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
DNA/RNA Synthesis   IKK   Autophagy   Mitophagy   Sirtuin   Apoptosis   Bacterial   Fungal   Antibiotic   Keap1-Nrf2  
Neurological, Eye or Ear Disease   Prostate Cancer   Liver Cancer   Bacterial Infection   Fungal Infection   Digestive System Inflammation   Glucose Metabolism   SARS-CoV-2 Infection   Obesity   Lung Fibrosis  
175
HY-100487 TAK-243
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.
E1/E2/E3 Enzyme   NF-κB   Apoptosis  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
97
HY-L007 Immunology/Inflammation Compound Library
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 8,643 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Signaling Pathway Targeting Libraries

89
HY-L109 Protein-protein Interaction Inhibitor Library
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 826 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

Signaling Pathway Targeting Libraries

86
HY-L014 NF-κB Signaling Compound Library
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,801 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

85
HY-L029 Autophagy Compound Library
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 2,080 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Signaling Pathway Targeting Libraries

84
HY-L033 Peptidomimetic Library
Peptidomimetics are compounds whose essential elements (pharmacophore) mimic a natural peptide or protein in 3D space and which retain the ability to interact with the biological target and produce the same biological effect. Peptidomimetics are designed to circumvent some of the problems associated with a natural peptide: e.g. stability against proteolysis (duration of activity) and poor bioavailability. Certain other properties, such as receptor selectivity or potency, often can be substantially improved. The design and synthesis of peptidomimetics are most important because of the dominant position peptide and protein-protein interactions play in molecular recognition and signaling, especially in living systems. Hence mimics have great potential in drug discovery. MCE Peptidomimetic Library contains 370 compounds including peptoid, α-helix mimetics, β-turn/sheets mimetics, etc. This library is an indispensable tool of structure-activity relationships in drug discovery.

Structure Classified Libraries

84
HY-L050 Ubiquitination Compound Library
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 507 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Signaling Pathway Targeting Libraries

84
HY-L051 Ferroptosis Compound Library
Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 1,255 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Signaling Pathway Targeting Libraries

84
HY-L059 Pyroptosis Compound Library
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 2,034 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L180 Mitophagy Compound Library
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 655 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Signaling Pathway Targeting Libraries

84
HY-L0119V Asinex PPI Pre-Plated Library
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.
83
HY-L041 Macrocyclic Compound Library
Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity. MCE offers a unique collection of 468 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

Structure Classified Libraries

83
HY-L128 E3 Ligase Ligand Library
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2). MCE carefully prepared a unique collection of 187 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Compound Characteristic Classified Libraries

83
HY-L129 Target Protein Ligand Library
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance. MCE carefully prepared a unique collection of 128 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

Compound Characteristic Classified Libraries

83
HY-L137 Molecular Glue Compound Library
Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention. Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy. MCE supplies a unique collection of 124 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

Compound Characteristic Classified Libraries

83
HY-L155 Mitochondrial Toxicity Compound Library
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 545 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Compound Characteristic Classified Libraries Signaling Pathway Targeting Libraries

83
HY-L156 Autoimmune Disease Compound Library
Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A). MCE designs a unique collection of 1,040 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Disease Focused Libraries

83
HY-L161 Cytokine Inhibitors Library
Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases. MCE designs a unique collection of 1,416 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

Signaling Pathway Targeting Libraries

83
HY-L174 Macrophage Related Compound Library
Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 276 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L175 Inflammasomes related Compound Library
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L204 Lactic Acid Metabolic Compound Library
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 582 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
83
HY-L219 Antimicrobial Peptides Library
Antimicrobial Peptides (AMPs), also known as antimicrobial peptides or antibiotic peptides, are a class of polypeptides encoded by specific genes in various biological cells and induced by external stimuli. They exhibit broad-spectrum bioactivity against bacteria, fungi, viruses, protozoa, and even tumor cells. AMPs serve as crucial effector molecules in the host's innate immune system.Due to their wide antimicrobial spectrum, low toxicity to normal cells of higher animals, high safety profile, low tendency to induce resistance, and additional benefits such as immune enhancement and antioxidant effects, antimicrobial peptides hold significant promise in new drug development. MCE offers 58 types of antimicrobial peptides, which can be applied in high-throughput screening for research in anti-infection therapies, immunotherapy, anticancer drug development, and agricultural disease control.
83
HY-L222 PROTAC Linkers Library
Linkers play a necessary role in the physicochemical properties and biological activity of the bifunctional molecule. These linkers are not a simply connection of two functional modules together, but its design and nature directly affect the stability, activity, selectivity, pharmacokinetics, and ultimately the therapeutic efficacy of the entire molecule. The length of the linker determines the extent of interaction between the two ligands and thus the maximum activity of the PROTAC molecule. MCE has collected 1,213 PROTAC Linkers can be used for the design and synthesis of bifunctional molecules.
83
HY-L226 Posttranslational Modification Library
Post-translational modifications (PTMs) refer to chemical modifications that occur on amino acid residues of proteins after translation, involving the addition or removal of specific functional groups. These modifications regulate protein activity, localization, folding, and interactions with other biomolecules. By influencing protein function, PTMs play a crucial role in various pathophysiological processes. Common types of PTMs include protein phosphorylation, methylation, acetylation, ubiquitination, glycosylation, and more. MCE offers 3,693 PTM-targeting compounds, which can be used for drug screening in cancer, neurodegenerative diseases, metabolic disorders, etc.
83
HY-L234 Nucleotide Metabolite Compound Library
Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs. MCE can provide 83 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.

Metabolism Focused Libraries

83
HY-L237 Pattern Recognition Receptors Library
Pattern Recognition Receptors (PRRs) are a crucial class of protein molecules expressed in cells of the innate immune system. The core function of Pattern Recognition Receptors is to recognize Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs). Upon recognizing and binding to PAMPs or DAMPs, PRRs rapidly initiate intracellular signaling pathways (such as the NF-κB, IRF, and inflammasome pathways). This triggers the production of inflammatory factors, chemokines, and type I interferons, thereby initiating inflammatory responses to eliminate pathogens or repair damage. PRRs represent the body's first line of defense against infection, and the rapidity and broad specificity of their response are crucial for host survival. However, aberrant activation of PRR signaling is also a cause of many chronic inflammatory diseases, autoimmune disorders, and neurodegenerative diseases. Therefore, precisely regulating PRR activity has become a key therapeutic strategy for these conditions. MCE has cataloged 338 inhibitors targeting key PRRs, such as NLRs, TLRs, C-type Lectin Receptors (CLRs), and cGAS, to support drug discovery efforts for chronic inflammatory diseases.
83
HY-L250 Lactic Acid Metabolite Compound Library
In the progression of various diseases, metabolic reprogramming has emerged as a key hallmark. Lactate, as an important metabolic signaling molecule, is widely involved in tumorigenesis, immune regulation, and inflammatory responses. Particularly within the tumor microenvironment, the abnormal accumulation of lactate not only affects cellular energy metabolism but also promotes disease progression by modulating immune cell functions and mediating protein lactylation, thereby participating in epigenetic regulation and signaling networks. Therefore, systematic investigation of lactate metabolic pathways and their associated metabolites is of great significance for understanding disease mechanisms and developing novel therapeutic strategies. The MCE lactic acid metabolite compound library contains 61 compounds and is constructed around key metabolic pathways involving lactate production, transport, and utilization. This library systematically includes core intermediates from glycolysis, the tricarboxylic acid (TCA) cycle, and the lactate cycle. Focusing on disease-associated metabolic reprogramming, it is suitable for research in oncology, inflammation, and metabolic disorders. The library can be used to elucidate the roles of lactate in tumor microenvironment regulation, immune evasion, and epigenetic modifications (such as protein lactylation). In addition, it provides high-quality small-molecule resources for drug screening, facilitating the discovery of potential modulators targeting key enzymes (such as LDH) or transporters (such as MCTs) involved in lactate metabolism.

Signaling Pathway Targeting Libraries

83
HY-L907 MCE Kinase Hinge Binder Fragment Library
The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity. The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments. MCE provides over 12,373 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.

Functional Fragment Libraries

83
HY-L917 RNA Binding Library
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs. MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.

Focused and target libraries

83
HY-L918 Molecular Glue-like Compound Library
Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms. Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases. Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Focused and target libraries

83
HY-L925 Cysteine Protease Focused Library
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors. This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Focused and target libraries

83
HY-L926 Cysteine Protease Focused Covalent Library
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors. This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

Focused and target libraries

83
HY-L935 Molecular Glue POI binding Fragment library
POI (Protein of Interest) refers to the target protein, namely the disease-causing protein or key functional protein that undergoes degradation or functional modulation in molecular glue-mediated processes. The Molecular Glue POI Library consists of a series of fragments that can specifically bind to different types of POIs. As key components of molecular glues, these ligands form stable interactions with target proteins, laying the foundation for molecular glues to induce the interaction between POIs and E3 ubiquitin ligases. The covered POIs include various types such as cancer-associated GSPT1, androgen receptors, and abnormally aggregated proteins linked to neurodegenerative diseases. This fragment library can be applied to the screening and optimization of targeted protein degraders. By screening ligands with high affinity and strong selectivity for specific POIs from the library, core structures can be identified to develop novel molecular glues. For instance, optimization of ligands targeting GSPT1 has yielded molecular glue degraders with enhanced degradation activity. Since many POIs are difficult to drug due to the lack of traditional small-molecule binding pockets, some ligands in the POI Ligand Library can modulate such POIs by inducing protein-protein interactions, thereby further expanding the scope of drug discovery for undruggable targets. MCE has compiled a POI Fragment Library comprising thousands of POI fragments with molecular weights ranging from 150 to 400. This compound library can be widely applied in Molecular Glue research and development.

Featured Fragment Libraries

83
HY-10029 Nutlin-3a
Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.
MDM-2/p53   E1/E2/E3 Enzyme   Autophagy   Apoptosis  
Colorectal Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation  
78
HY-18234A Leupeptin hemisulfate
Leupeptin hemisulfate is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis.

Source: Streptomyces roseus MB-26-AI

Ser/Thr Protease   Cathepsin   Autophagy   SARS-CoV   Atg8/LC3   NO Synthase   COX   p62   Arginase   PTEN   NF-κB   PI3K   Akt   p38 MAPK   ERK   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Respiratory Disease   Coronavirus Infection   Skin Disease  
69
HY-Y1269D Ammonium chloride, for molecular biology
Ammonium chloride (Salmiac), for molecular biology is an inhibitor of Slc26a4 and SMAD2. Ammonium chloride, for molecular biology reduces the protein expression level of Slc26a4 in lung tissue, and attenuates ozone-induced increases in proinflammatory cytokines, inflammatory cells, pulmonary resistance, goblet cell hyperplasia, peribronchial inflammation and thiocyanate levels in mouse tissues and bronchoalveolar lavage fluid. Ammonium chloride, for molecular biology decreases the level of phosphorylated SMAD2, inhibits autophagy by reducing autophagy-related proteins, and enhances Cisplatin (HY-17394)-induced cancer cell apoptosis and DNA double-strand breaks. Ammonium chloride, for molecular biology also inhibits the TCA cycle, reduces ATP production, increases glucose utilization, regulates the levels of lactic acid, glutamic acid and ATP, and induces morphological degeneration of neuroblastoma cells. Ammonium chloride, for molecular biology can be used in studies related to ozone-induced airway injury, hepatocellular carcinoma, human cervical cancer, hepatic encephalopathy, Reye syndrome, epilepsy and neurodegenerative diseases.
TGF-beta/Smad   Apoptosis   Chloride Channel  
Cancer   Epilepsy  
62
HY-Y1269C Ammonium chloride, for cell culture
Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor.
Environmental Pollutants   Autophagy   Biochemical Assay Reagents  
Cancer   Infection  
62
HY-Y1269 Ammonium chloride, AR, 99.5%
Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor.
Environmental Pollutants   Autophagy  
Cancer   Infection  
62
HY-15676 Idasanutlin
Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC50 of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors.
MDM-2/p53   E1/E2/E3 Enzyme   Apoptosis   Pyroptosis   Reactive Oxygen Species (ROS)   Caspase  
Musculoskeletal and Skin Disease   Colorectal Cancer   Melanoma   Neuroblastoma   Osteosarcoma   Non-Small Cell Lung Cancer   Acute Myeloid Leukemia   Non-Hodgkin Lymphoma  
52
HY-10074 TPCA-1
TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.
IKK   STAT   Apoptosis  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   Obesity  
47
HY-50696 Nutlin-3
Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
MDM-2/p53   E1/E2/E3 Enzyme  
Colorectal Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer  
43
HY-N0141 Parthenolide
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
NF-κB   Autophagy   Mitophagy   Apoptosis   IKK  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Non-Small Cell Lung Cancer   SARS-CoV-2 Infection   Contact Dermatitis   Obesity  
42
HY-10514 BX795
BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy.
PDK-1   IKK   Autophagy  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Obesity  
42
HY-108702 ML-792
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively).
E1/E2/E3 Enzyme  
Liver Cancer  
39
HY-10519 BMS-345541
BMS-345541 is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
IKK  
Prostate Cancer   Liver Cancer  
38
HY-111789 Subasumstat
Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
E1/E2/E3 Enzyme  
Inflammation or Immune System Disease   Liver Cancer  
38
HY-13687 IKK 16
IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.
IKK   LRRK2   P-glycoprotein   PKD   NF-κB   TNF Receptor   Interleukin Related  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
32
HY-B0221 Amphotericin B
Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

Source: Streptomyces nodosus

Fungal   Antibiotic   Bacterial   Parasite  
Cancer   Viral Infection   Bacterial Infection   Fungal Infection   Parasitic Infection   SARS-CoV-2 Infection  
32
HY-111941 GSK8612
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
IKK  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Prostate Cancer   Liver Cancer  
31
HY-B0713 Amlexanox
Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
IKK  
Metabolic or Endocrine Disease   Prostate Cancer   Liver Cancer   SARS-CoV-2 Infection  
30
HY-13018 MRT67307
MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.
IKK   ULK   Autophagy  
Inflammation or Immune System Disease   Prostate Cancer   Liver Cancer  
29
HY-12296 Navtemadlin
Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM.
MDM-2/p53   E1/E2/E3 Enzyme  
26
HY-N0527 Pentagalloylglucose
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities.
JAK   Keap1-Nrf2   Apoptosis   β-catenin   Reactive Oxygen Species (ROS)   E1/E2/E3 Enzyme  
Neurological, Eye or Ear Disease   Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
16
HY-B0298A Clemastine fumarate
Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .
Histamine Receptor   Pyroptosis   Autophagy   mAChR   p62   IKK   Apoptosis   Keap1-Nrf2   mTOR  
Parkinson's Disease   Obesity  
15
HY-114166 2-D08
2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM.
E1/E2/E3 Enzyme   TAM Receptor  
Liver Cancer  
12
HY-17567 Heparin
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.
Exosomes   Thrombin   Autophagy   Endogenous Metabolite   Bacterial  
Cancer   Blood or Cardio-cerebrovascular Disease   Coronavirus Infection   Bacterial Infection  
11
HY-P2260A Tat-beclin 1 TFA
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
Autophagy   HIV  
Infection  
7
HY-P2260 Tat-beclin 1
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
CHIKV   Autophagy   HIV  
Infection  
7
HY-112904 XRK3F2
XRK3F2 is a p62 (sequestosome-1) ZZ domain inhibitor that has specificity for the p62-ZZ domain over other p62 signaling domains. XRK3F2 blocks TNFα effects and upregulation in bone marrow stromal cells, and induces multiple myeloma cell apoptosis. XRK3F2 can be used for the research of multiple myeloma bone disease, acute myeloid leukemia, and multiple myeloma.
p62   Autophagy  
Leukemia/Lymphoma/Myeloma  
7
HY-N0901A Corynoxine B
Corynoxine B is an alkaloid-based autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances α-synuclein (α-syn) clearance in Parkinson's disease mice.
α-synuclein  
Cancer   Parkinson's Disease  
6
HY-115576 P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.
p62   Mitosis   Autophagy   Mitophagy  
Cancer   Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
6
HY-122550 Artemisitene
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.
Keap1-Nrf2   Topoisomerase   Apoptosis  
Digestive System Disease   Lung Cancer   Digestive System Inflammation   Obesity   Lung Fibrosis  
4
HY-B2123 Lactose
Lactose is a β-galactoside consisting of galactose and glucose residues, the main carbohydrate in mammalian breast milk. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory functions.
Environmental Pollutants   ERK   Interleukin Related   Endogenous Metabolite   NF-κB  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   SARS-CoV-2 Infection   Obesity  
4
HY-P99156 Relatlimab
Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer.

Species: Human

LAG-3  
Non-Small Cell Lung Cancer  
4
HY-W020033 Lanosterol
Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases.
Endogenous Metabolite  
Alzheimer's Disease   Parkinson's Disease  
4
HY-44134 Dimethyl 2-oxoglutarate
Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy.
Endogenous Metabolite   Drug Derivative   Autophagy   Mitochondrial Metabolism   Reactive Oxygen Species (ROS)  
Glucose Metabolism   Alzheimer's Disease   Cardiomyopathy   Hepatic Fibrosis  
4
HY-32350 Ercalcitriol
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases.
VD/VDR   Drug Metabolite   Endogenous Metabolite  
Metabolic or Endocrine Disease  
3
HY-P5819A xStAx-VHLL TFA
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity.
PROTACs   β-catenin   Wnt  
3
HY-N0610 Trans-Cinnamic acid
trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1.
Environmental Pollutants   Bacterial   Endogenous Metabolite  
Cancer   Bacterial Infection   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
3
HY-P5819 xStAx-VHLL
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity.
Wnt   β-catenin   PROTACs  
3
HY-129395 Mezigdomide
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity.
E1/E2/E3 Enzyme   Molecular Glues   Apoptosis  
Liver Cancer   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation  
3
HY-W016412 Coenzyme Q0
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling.
Apoptosis   Autophagy   EGFR   Akt   mTOR   Caspase   Bcl-2 Family   Reactive Oxygen Species (ROS)   PARP   COX   NO Synthase   TNF Receptor   Interleukin Related   MMP   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
2
HY-N5024 Gambogenic acid
Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer.
Histone Methyltransferase  
Leukemia/Lymphoma/Myeloma  
2
HY-W010201 Citronellol
Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
p62   Environmental Pollutants   Fungal   Atg8/LC3   PI3K   Autophagy   ERK   Apoptosis   Necroptosis   Reactive Oxygen Species (ROS)   TNF Receptor  
Respiratory Disease   Breast Cancer   Pancreatic Cancer   Fungal Infection   Pain   Autoimmune Disease   Digestive System Inflammation   Cardiovascular Disease   Non-Small Cell Lung Cancer   Parkinson's Disease  
2
HY-129960 L-Selenocystine
L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity.
Keap1-Nrf2   Autophagy   p62   Apoptosis   Reactive Oxygen Species (ROS)   Caspase   Bcl-2 Family  
Inflammation or Immune System Disease  
2
HY-W018791 Bifendate
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR).
HBV   Autophagy   Cytochrome P450   Atg8/LC3   p62   P-glycoprotein  
Ovarian Cancer   Viral Infection   Cardiovascular Disease  
2
HY-125859 Peroxidase, Horseradish
Peroxidase, Horseradish actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases.
Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
2
HY-P99434 Amlitelimab
Amlitelimab () is an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb). Amlitelimab inhibits OX40-OX40L interaction, and can be used in the research of atopic dermatitis.

Species: Human

Others  
Inflammation or Immune System Disease  
2
HY-P5522 TriDAP
TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP decreases IκBα levels and increases p65 levels. TriDAP induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection.
NOD-like Receptor (NLR)   NF-κB   MAP3K   MEK   ERK   p38 MAPK   Interleukin Related   SARS-CoV  
Digestive System Inflammation   SARS-CoV-2 Infection   Crohn's Disease   Ulcerative Colitis  
1
HY-141567 Pseudouridine 5'-triphosphate
Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection.
DNA/RNA Synthesis  
Viral Infection  
1
HY-P9801 Anti-Spike-RBD mAb
Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment.
SARS-CoV  
1
HY-B0469S Medroxyprogesterone acetate-d3
Medroxyprogesterone acetate-d3 is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
Progesterone Receptor   Androgen Receptor   Glucocorticoid Receptor  
Cancer   Metabolic or Endocrine Disease  
1
HY-P99736 Miptenalimab
Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II.

Species: Human

LAG-3  
Cancer  
1
HY-N6689 Destruxin A
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections.

Source: Metarhizium anisopliae

Insecticide   Bacterial  
Cancer   Infection   Inflammation or Immune System Disease  
1
HY-122815 Fusicoccin
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity.

Source: Fusicoccum amygdali

Apoptosis  
1
HY-N4247 Kuwanon G
Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis.
Bombesin Receptor   Bacterial   Apoptosis   Reactive Oxygen Species (ROS)   PI3K   Akt   GSK-3   MMP   mTOR   NF-κB   LXR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Alzheimer's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-N4180 Pennogenin 3-O-beta-chacotrioside
Pennogenin 3-O-beta-chacotrioside is an autophagy (autophagy) inducer. Pennogenin 3-O-beta-chacotrioside exhibits strong binding affinity for the pro-apoptotic proteins CYTC, AIF1 and BAX. Pennogenin 3-O-beta-chacotrioside triggers reactive oxygen species-induced autophagy in cancer cells. Pennogenin 3-O-beta-chacotrioside can be used in studies related to colorectal cancer.
Autophagy   Atg8/LC3   Reactive Oxygen Species (ROS)   Apoptosis  
Colorectal Cancer  
1
HY-B0469R Medroxyprogesterone acetate (Standard)
Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
Reference Standards   Progesterone Receptor   Androgen Receptor   Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
1
HY-D1056H Lipopolysaccharides, from S. marcescens
Lipopolysaccharides, from S. marcescens (Serratia marcescens) are lipopolysaccharide endotoxins and TLR-4 activators derived from Serratia marcescens, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. marcescens exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from S. marcescens induce NF-κB activation in mouse cells via Toll-like receptor (TLR4)/MD-2. The lipopolysaccharides of S. marcescens can induce apoptosis in host immune cells, thereby suppressing the host's innate immunity.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
1
HY-N1458 Isoschaftoside
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.
Parasite   Autophagy   p62   Reactive Oxygen Species (ROS)  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Parasitic Infection   Hypertension  
1
HY-141567A Pseudouridine 5'-triphosphate trisodium solution (100 mM)
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection.
DNA/RNA Synthesis  
Viral Infection  
1
HY-P99533 Urabrelimab
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction.

Species: Human

CD47   Interleukin Related  
Cancer  
1
HY-N9362 Emodinanthrone
Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC50=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury.
Ferroptosis   Antibiotic  
Infection   Cardiomyopathy  
1
HY-111126 K67
K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC50 of 1.5 μM. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC50 is 6.2 μM). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2.
p62   Keap1-Nrf2  
Colorectal Cancer   Liver Cancer   Ovarian Cancer  
1
HY-P2322 Iturin A
Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity.
Fungal   Reactive Oxygen Species (ROS)   Apoptosis   Autophagy  
Infection  
1
HY-B1920 Josamycin
Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM.

Source: Streptomyces narbonensis

Bacterial   Antibiotic  
Bacterial Infection   SARS-CoV-2 Infection  
1
HY-P99044 Sabatolimab
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.

Species: Human

Tim3  
Inflammation or Immune System Disease   Leukemia/Lymphoma/Myeloma   Non-Small Cell Lung Cancer  
1
HY-W041892 Dimethyl itaconate
Dimethyl itaconate induces innate immune memory (trained immunity), and exhibits immunomodulatory property. Dimethyl itaconate inhibits the activation of microglia, reduces the neuroinflammation and synaptic structural damage. Dimethyl itaconate regulates the composition of intestinal flora.
Reactive Oxygen Species (ROS)  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
1
HY-D1056B3 Lipopolysaccharides, from Klebsiella pneumoniae
Lipopolysaccharides, from Klebsiella pneumoniae (LPS, from bacterial (Klebsiella pneumoniae)) are lipopolysaccharide endotoxins and TLR4 activators derived from Klebsiella pneumoniae, and are classified as S-type LPS. Lipopolysaccharides, from Klebsiella pneumoniae exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from Klebsiella pneumoniae may participate in bacterial immune evasion by inhibiting complement-mediated killing and suppressing the host's secretion of antimicrobial peptides, thereby allowing the bacteria to escape immune defenses. Lipopolysaccharides, from Klebsiella pneumoniae possess high viscosity and resistance to serum-mediated killing, which may lead to sepsis. Lipopolysaccharides, from Klebsiella pneumoniae can be used to construct Acute Lung Injury Model.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
1
HY-P700392 UBAC1 Protein, Human (GST)
The UBAC1 protein is a non-catalytic component of the KPC complex and contributes to polyubiquitination, targeting proteins such as CDKN1B and NFKB1. The KPC complex regulates the cell cycle by ubiquitinating and degrading CDKN1B during G1 phase. UBAC1 Protein, Human (GST) is the recombinant human-derived UBAC1 protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

Ubiquitin Related Proteins Ubiquitin Enzymes E3 Ligases

1
HY-15371G Forskolin (GMP)
Forskolin (Coleonol) (GMP) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin (GMP) is also an inducer of intracellular cAMP formation. Forskolin (GMP) induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin (GMP) exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin (GMP) also induces autophagy.
Adenylate Cyclase   FXR   Autophagy   PKC  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P99698 Lesabelimab
Lesabelimab (LDP) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor.

Species: Human

PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-P99949 Etigilimab
Etigilimab (OMP-313M32), a humanized IgG1 monoclonal antibody, blocks TIGIT interaction with PVR (CD155; poliovirus receptor) and inhibits downstream signalling with target cell killing.

Species: Human

Others  
Cancer  
/
HY-135811S Desethyl chloroquine-d4
Desethyl chloroquine-d4 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.
Isotope-Labeled Compounds   Parasite   Toll-like Receptor (TLR)   Autophagy  
Infection  
/
HY-12222S Obeticholic acid-d5
Obeticholic acid-d5 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.
FXR   Autophagy  
/
HY-132001S1 Ziftomenib-d4
Ziftomenib-d4 (KO-539-d4) is the deuterium labeled Ziftomenib (HY-132001). Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities.
Isotope-Labeled Compounds   Epigenetic Reader Domain  
Cancer  
/
HY-D2977 AF-1
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH.
Fluorescent Dye   Autophagy   Fungal  
Fungal Infection  
/
HY-D0838S1 Dodecyltrimethylammonium-d34bromide
Dodecyltrimethylammonium-d34 (bromide) is the deuterium labeled Dodecyltrimethylammonium (bromide). Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.
Isotope-Labeled Compounds  
/
HY-158104 LPPM-8
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology.
ATF6  
/
HY-12292G IM-12 (GMP)
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca2+ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABLT315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia.
NF-κB   STAT   GSK-3   β-catenin   Bcr-Abl  
Leukemia/Lymphoma/Myeloma  
/
HY-W441002R DSPE-succinic acid (Standard)
Taurine (Standard) is the analytical standard of Taurine. This product is intended for research and analytical applications. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.
Liposome   Reference Standards  
/
HY-W750451 Reptoside
Reptoside, an iridoid glucoside, is a DNA damaging active agent. Reptoside has strong interactions with Trp352 and Tyr335 in AKT1.
Akt  
Cancer  
/
HY-10181GL Dasatinib (GMP Like)
Dasatinib (GMP Like) (BMS-354825 (GMP Like)) is Dasatinib (HY-10181) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib also induces apoptosis and autophagy.
Bcr-Abl   Src   Autophagy   Apoptosis  
/
HY-P11028 M1-20
M1-20 is a CDK1 inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model.
CDK  
/
HY-P4327 Hispidalin
Hispidalin is a novel antimicrobial peptide with broad and efficient antibacterial activity against various bacterial and fungal pathogens, and can be used as an antibacterial agent and food preservative.
Bacterial  
/
HY-B0925AS Oxacillin-d5
Oxacillin-d5 is the deuterium labeled Oxacillin. Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens.
Bacterial   Antibiotic  
Infection  
/
HY-P10066 Menin-MLL inhibitor 31
Menin-MLL inhibitor 31 (compound 18) is a potent inhibitor of the menin MLL interaction with an IC50 value of 4.6 nM.
Epigenetic Reader Domain  
Cancer  
/
HY-D2971 NCIC-VIS
NCIC-VIS is a lysosome-targeted, viscosity-sensitive two-photon near-infrared fluorescent probe. NCIC-VIS has a rigid structure that can restrict molecular torsion, thereby increasing the fluorescence quantum yield and two-photon absorption cross-section. NCIC-VIS enables real-time imaging of the autophagy process in cells.
Fluorescent Dye   Autophagy  
/
HY-D3211 HJTA
HJTA is a selective, pH/GSH dual-responsive Fluorescent probe and anticancer agent. HJTA selectively undergoes an enzymatic reaction with GSTπ. HJTA induces Apoptosis and Autophagy by regulating the expression of apoptotic and autophagic proteins. HJTA exhibits pH- and GSH-dual-responsive fluorescence in tumor cells. HJTA selectively illuminates tumor tissues, enabling precise in situ visualization of colon tumors. HJTA exerts anticancer effects against colon cancer. HJTA can be used for colon cancer research.
Fluorescent Dye   Apoptosis   Autophagy  
Colorectal Cancer  
/
HY-P11343 Verlamelin B
Verlamelin B (Compound 147) is effective against plant pathogenic fungal and is a derivative of Verlamelin (HY-N14856).Verlamelin B exhibits potent plant protective activity in vivo, particularly against rice blast and barley powdery mildew. Verlamelin B causes morphological changes in fungal cells, such as swelling or expansion. Verlamelin B exhibits weaker antifungal activity in vitro against plant pathogens such as rice blast, Dipolaris zeae, and Botrytis cinerea. Verlamelin B is useful for research on antifungal activities against plant pathogens.

Source: Lecanicillium sp.

Fungal  
Infection  
/
HY-135811S1 Desethyl chloroquine-d5
Desethyl chloroquine-d5 is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.
Isotope-Labeled Compounds   Parasite   Toll-like Receptor (TLR)   Autophagy  
Infection  
/
HY-W768347 Xylitol-13C5
Xylitol-13C5 (Xylite-13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model.
Isotope-Labeled Compounds   Endogenous Metabolite   Autophagy   Atg7   Bacterial   Atg8/LC3  
/
HY-N9826 Icterogenin
Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development.
Bcl-2 Family  
Leukemia/Lymphoma/Myeloma  
/
HY-P10343 Soybean peptide QRPR
Soybean peptide QRPR is an agonist of Autophagy. Soybean peptide QRPR activates cellular autophagy by upregulating the expression and activity of PIK3, AKT, and mTOR. Soybean peptide QRPR can reduce the inflammatory response.
Autophagy  
Inflammation or Immune System Disease  
/
HY-P11792 CP2-CPP
CP2-CPP is a conjugate of p27 Analogue CP2 (HY-P11020) and Antennapedia Peptide (HY-P0307). CP2-CPP crosses cell membranes and localizes to live cell cytosol. CP2-CPP blocks SCFSkp2/Cks1-p27 interaction to inhibit p27 ubiquitination and degradation, restoring p27 levels and inhibiting cell proliferation. CP2-CPP can be used for the research of cancer, such as breast cancer.
E1/E2/E3 Enzyme  
Breast Cancer  
/
HY-P5109 Minigastrin
Minigastrin is an acidic peptide. Minigastrin can be used to study peptidepeptide interaction.
Cholecystokinin Receptor  
/
HY-100596G AS1842856 (GMP)
AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1.
Autophagy  
Metabolic or Endocrine Disease  
/
HY-170220 PacFA Ceramide
PacFA Ceramide is a 15-carbon long photoactivatable and clickable fatty acid. PacFA Ceramide can be used for the analysis of protein-lipid interactions in living cells.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-N20382 Tripterygium wilfordii extract
Tripterygium wilfordii extract is an extract of Tripterygium wilfordii that can induce autophagy.
Autophagy  
Cancer  
/
HY-167816 1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine
1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine (21:0 PC) is a surfactant with antibacterial activity. 1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine can act in mucus to help prevent the spread of pathogens. 1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine plays a protective role in biofilms, maintaining the health of organisms.
Bacterial  
/
HY-N0610S trans-Cinnamic acid-d5
trans-Cinnamic acid-d5 is the deuterium labeled trans-Cinnamic acid. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1.
Bacterial   Endogenous Metabolite  
Infection  
/
HY-D1595 BODIPY FL Cholesterol
BODIPY FL Cholesterol is a green fluorescent, lipophilic probe. BODIPY FL Cholesterol can be used for the research of lipid transport processes and lipid-protein interactions.
Fluorescent Dye  
/
HY-D3005 NpCy-4
NpCy-4 is a reliable reporter for monitoring lysosomal pH and viscosity changes in real time during Autophagy (λex = 650 nm; λem = 660-740 nm). NpCy-4 demonstrates a superior signal-to-background ratio (SBR) for cellular imaging. NpCy-4 facilitates real-time, noninvasive diagnostic imaging of acute gastritis model with high contrast.
Fluorescent Dye   Autophagy  
Gastric Disease  
/
HY-P1720 Telomycin
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens.
Antibiotic   Bacterial  
Infection  
/
HY-P991305 AGEN-1571
AGEN-1571 is a human IgG1 monoclonal antibody (mAb) targeting ILT2. AGEN-1571 promotes adaptive and innate immune responses. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-D1056C4 Lipopolysaccharides, from S. enterica serotype abortus equi
Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype Abortusequi are lipopolysaccharide endotoxins and TLR-4 activators derived from the Abortusequi serotype of S. enterica, classified as a mutated R-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype abortus equi consist of core oligosaccharide (core oligosaccharide) and lipid A (Lipid A). S. enterica serotype Abortusequi is a major pathogen causing abortion in mares and is also associated with neonatal sepsis, multiple abscesses, orchitis, and polyarthritis in equids. It is primarily grouped based on lipopolysaccharides (O-antigen) and flagellin (H-antigen).
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
/
HY-P2291 Beta-defensin 103 isoform X1, pig
Beta-defensin 103 isoform X1, pig is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens.
Bacterial  
Inflammation or Immune System Disease  
/
HY-P10711 ALA-A2 peptide
ALA-A2 is an anticancer peptide discovered in alpha-lactalbumin that selectively kills cancer cells by inducing Autophagy. ALA-A2 has cell-penetrating capabilities, allowing it to effectively enter cells without relying on membranolytic effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. ALA-A2 holds promise for research in cancer therapy and autophagy regulation.
Autophagy  
/
HY-178411S Dodecyltrimethylammonium-d9 bromide
Dodecyltrimethylammonium-d9 bromide is the deuterium labeled Dodecyltrimethylammonium bromide (HY-D0838). Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-W725496 D-Fructose 6-phosphate dipotassium
D-Fructose 6-phosphate dipotassium is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose 6-phosphate dipotassium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate dipotassium can be used to study Lewy body dementia.
Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P3151A Gliadin p31-43 TFA
Gliadin p31-43 TFA is an undigested gliadin peptide. Gliadin p31-43 TFA induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 TFA can be used for celiac disease research.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-N20679 Aequinetin
Aequinetin is a tyrosinase inhibitor, and docking results show that it forms hydrogen bonds and hydrophobic interactions with key protein residues of NF-κB p65, MAPK10 and ERK1.
Drug Derivative   Tyrosinase  
/
HY-B0469S1 Medroxyprogesterone acetate-d7
Medroxyprogesterone acetate-d7 (Medroxyprogesterone 17-acetate-d7) is the deuterium labeled Medroxyprogesterone acetate (HY-B0469) . Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
Isotope-Labeled Compounds   Progesterone Receptor   Glucocorticoid Receptor   Androgen Receptor   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-152228 SMYD3-IN-2
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer.
Histone Methyltransferase   Autophagy  
/
HY-D0330 Mordant black 17
Mordant black 17 (Sunchromine blue black R) is a versatile chelating agent, demonstrating significant adsorptive properties through its interaction with metal ions, enhancing the efficiency of polymeric materials in various applications.
Biochemical Assay Reagents  
/
HY-N10305 Clionamine B
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells.

Source: Cliona celata

Autophagy  
/
HY-D0838S Dodecyltrimethylammonium-d25 bromide
Dodecyltrimethylammonium-d25 (bromide) is the deuterium labeled Dodecyltrimethylammonium (bromide). Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.
Isotope-Labeled Compounds  
/
HY-P10682 PuroA
PuroA is a tryptophan-rich domain of Puroindoline a that exerts antibacterial activity through interaction with bacterial membranes.
Bacterial  
Infection  
/
HY-Y1754 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid
2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) is a compound with the ability to probe conformational changes, folding processes and interactions of peptides and proteins. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid is often used in relevant biological research to gain a deeper understanding of the behavior and function of biomacromolecules. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid plays an important role in analyzing the interactions and dynamic responses of biological systems.
Biochemical Assay Reagents  
/
HY-W745714 Oxacillin-d5 sodium salt
Oxacillin-d5 sodium salt (HY-B0925) is the deuterium labeled Oxacillin sodium salt. Oxacillin sodium salt is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens.
Isotope-Labeled Compounds   Bacterial   Antibiotic  
Infection  
/
HY-NP057 Ovalbumin-AF555
Ovalbumin-AF555 is an AF555 conjugated ovalbumin (Ex=555 nM, Em=565 nm). Ovalbumin-AF555 can be used in the research of cell interaction.
Biochemical Assay Reagents  
/
HY-P2318 Bac2A TFA
Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.
Fungal  
Infection  
/
HY-B0850S Difenoconazole-d6 hydrochloride
Difenoconazole-d6 (hydrochloride) is deuterium labeled Difenoconazole. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
Isotope-Labeled Compounds   Fungal  
Infection  
/
HY-P2269 MAIT-203
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
Drug Derivative  
/
HY-W011117S Danofloxacin-d3
Danofloxacin-d3 is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.
Isotope-Labeled Compounds   Bacterial   DNA/RNA Synthesis   Antibiotic  
Mycoplasma Infection   Chlamydia Infection  
/
HY-N3486 Isodunnianol
Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity.
Autophagy  
Blood or Cardio-cerebrovascular Disease  
/
HY-P5984 Thioether-cyclized helix B peptide, CHBP
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.
mTOR  
/
HY-12041G SP600125 (GMP)
SP600125 (GMP) is SP600125 (HY-12041) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis.
JNK   Autophagy   Apoptosis   Ferroptosis  
Bladder Cancer  
/
HY-182660 Acetosyringone Sterile Solution (100 mM)
Acetosyringone Sterile Solution (100 mM) is formulated with acetosyringone, ethanol, etc., and is sterilized by filtration. It can be used for plant pathogen identification. It effectively induces the virulence genes of Agrobacterium tumefaciens.
Biochemical Assay Reagents  
/
HY-N20712 Anisomelic acid
Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor. Anisomelic acid directly interacts with HPV16 E6, promotes its ubiquitination and proteasomal degradation by recruiting E3 ubiquitin ligase, downregulates E6 and facilitates E7 degradation. Anisomelic acid induces endogenous mitochondrial apoptosis, activates caspase-3, causes cleavage of PARP, and triggers p53-independent endogenous apoptosis by depleting cIAP2. Anisomelic acid can be used in research related to HPV-positive cancers and cervical cancer.
HPV   Apoptosis   Caspase   PARP   IAP  
Cervical Cancer  
/
HY-N9362R Emodinanthrone (Standard)
Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC50=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury.
Reference Standards   Antibiotic   Ferroptosis  
Infection  
/
HY-N19738 Obtusaquinone
Obtusaquinone is a blood-brain barrier-permeable Keap1 inhibitor with anticancer activity. Obtusaquinone covalently binds to cysteine residues of Keap1, promotes its ubiquitination and proteasomal degradation, and activates the Nrf2 pathway. Obtusaquinone induces endoplasmic reticulum stress and DNA damage through abnormal accumulation of ROS, and triggers apoptosis of cancer cells. Obtusaquinone prolongs survival in orthotopic xenograft models of pediatric high-grade glioma, and exhibits antitumor activity in glioblastoma and breast cancer models. Obtusaquinone can be used in studies related to glioma and breast cancer.
Keap1-Nrf2   Reactive Oxygen Species (ROS)   Apoptosis  
Breast Cancer   Glioma  
/
HY-P992351 ELB021
ELB021 is an antibody inhibitor targeting the CD160 checkpoint. ELB021 specifically binds to CD160 on the cell surface and blocks its immune checkpoint pathway, thereby stimulating innate and adaptive anti-tumor immune responses. ELB021 effectively eliminates CD160-expressing cancer cells by enhancing T cell proliferation and CD8+ T cell-mediated cytotoxicity. Independent of PD-1 regulation, ELB021 is applicable to research related to B-cell leukemia and HIV-1 infection.

Species: Human

Others  
Leukemia/Lymphoma/Myeloma   HIV-1 Infection  
/
HY-P992396 KTN0073
KTN0073 is a high-affinity MET receptor tyrosine kinase inhibitor. KTN0073 can be used in studies related to non-small cell lung cancer and human cancers driven by HGF, MET amplification, or exon 14 mutation. KTN0073 binds to the Sema/PSI domain to block the HGF-MET interaction, and induces ubiquitination and degradation of oncogenic MET receptors via an HGF-independent pathway, thereby inhibiting MET-dependent signal transduction. KTN0073 exhibits significant antitumor activity in vivo, and its tumor suppressive activity is superior to that of the IgG1 subtype when grafted to the IgG2 constant region.

Species: Human

c-Met/HGFR  
Cancer  
/
HY-122292 Celastramycin A
Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml. Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml.

Source: Drosophila

Antibiotic   Bacterial  
Infection   Inflammation or Immune System Disease  
/
HY-N21759 Dendroside D
Dendroside D is a sesquiterpenoid compound. Dendroside D binds to the RNA site of RNA-dependent RNA polymerase and the active site of SARS-CoV-2 main protease through hydrogen bonds, electrostatic interactions, and hydrophobic interactions, thereby blocking viral replication. Dendroside D stimulates the proliferation of mouse T and B lymphocytes, promotes T and B lymphocyte proliferation, and exhibits immunomodulatory activity. Dendroside D can be used for viral infection and immune-related research.
Endogenous Metabolite   DNA/RNA Synthesis  
Inflammation or Immune System Disease   Viral Infection  
/
HY-P2291A Beta-defensin 103 isoform X1, pig TFA
Beta-defensin 103 isoform X1, pig TFA is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens.
Bacterial  
Inflammation or Immune System Disease  
/
HY-132001S Ziftomenib-d3
Ziftomenib-d3 (KO-539-d3) is the deuterium labeled Ziftomenib (HY-132001). Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities.
Isotope-Labeled Compounds   Epigenetic Reader Domain  
Cancer  
/
HY-P10543 SMRT peptide
SMRT peptide is one of the co-repressors of BCL6 BTB domain interaction. SMRT peptide binds to the BTB domain of BCL6 and enhances the transcriptional repression function of BCL6. SMRT peptide can be used to study protein-protein interactions.
BCL6  
Cancer  
/
HY-N6714R Alternariol (Standard)
Alternariol (Standard) is the analytical standard of Alternariol. This product is intended for research and analytical applications. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.
Reference Standards   Topoisomerase   Androgen Receptor   Estrogen Receptor/ERR   Apoptosis  
Cancer   Infection  
/
HY-125745 Loloatin B 10
Loloatin B 10 is an antibiotic, which exhibits antibacterial efficacy against gram positive antibiotic resistant human pathogens.
Antibiotic   Bacterial  
/
HY-P2457 rCRAMP (rat)
rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS.
Bacterial  
Inflammation or Immune System Disease  
/
HY-N12905 Celastramycin A (isomer)
Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL.

Source: Streptomyces strains

Antibiotic   Bacterial  
/
HY-W096997S Sodium octyl sulfate (SOS)-d17
Sodium octyl sulfate (SOS)-d17 (Sodium capryl sulfate-d17) is the deuterated analogue of Sodium octyl sulfate (SOS). Sodium octyl sulfate (Sodium capryl sulfate; SOS) is a medium‑chain anionic surfactant. Sodium octyl sulfate (SOS) can undergo strong hydrophobic interactions with serum albumins (such as human serum albumin (HSA) and bovine serum albumin (BSA)), while exhibiting weak interactions with other proteins including myoglobin and hemoglobin. As an environmental pollutant in freshwater ecosystems, Sodium octyl sulfate (SOS) can mimic interspecific pheromones released by Daphnia magna and induce the formation of multicellular colonies in green algae.
Isotope-Labeled Compounds  
/
HY-129493 Lateropyrone
Lateropyrone is a type of pyranone antibiotic that can inhibit Gram-negative bacteria, and it's a secondary metabolite produced by the oat fungal pathogen.

Source: Fusarium

Bacterial   Antibiotic   Endogenous Metabolite  
Infection  
/
HY-D0584 Reactive orange 86
Reactive orange 86 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-D0668 Reactive orange 13
Reactive orange 13 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-121125 Aucubigenin
Aucubigenin, the aglycone of the iridoid glycoside aucubin, has been characterized through X-ray diffraction analysis. Its crystal structure reveals monoclinic symmetry with specific conformations adopted by its cyclopentane and pyran rings. The study also determined the absolute configurations of both aucubin and aucubigenin. Significant O-H O hydrogen bonding interactions were observed in the crystal lattices of both compounds, highlighting their structural stability and potential for intermolecular interactions.
Others  
/
HY-P5407 HD5
HD5 is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer.
SARS-CoV   Angiotensin-converting Enzyme (ACE)  
Colorectal Cancer   Small Cell Lung Cancer   Epithelial Ovarian Cancer   SARS-CoV-2 Infection   HPV Infection  
/
HY-D0653 Reactive orange 35
Reactive orange 35 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-N16463 QS-S2
QS-S2 is the impurity of QS-21 (HY-101092A). QS-21 is an innate immune system-targeted adjuvant.
Drug Intermediate  
/
HY-111582G BBIQ (GMP)
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
/
HY-126757 Linichlorin A
Linichlorin A is a p27Kip1 ubiquitination inhibitor that blocks p27Kip1 degradation by inhibiting the Skp2-Cks1–p27Kip1 interaction. Linichlorin A shows selective antiproliferative activity against tumor cells. Linichlorin A induces apoptosis in leukemia cells via cytochrome c release, caspase activation and PARP cleavage. Linichlorin A can be used in the study of leukemia, melanoma, cervical cancer and breast cancer.
Caspase   Apoptosis   PARP  
Breast Cancer   Cervical Cancer   Melanoma   Blood Disease  
/
HY-D0622 Reactive Green 19
Reactive Green 19 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-D0514 Reactive blue 5
Reactive blue 5 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-N0916 Monomelittoside
Monomelittoside is a iridoid glycoside with antibacterial activity. Monomelittoside inhibits dental caries pathogen Streptococcus.
Bacterial  
Inflammation or Immune System Disease   Bacterial Infection  
/
HY-D0522 Reactive orange 16
Reactive orange 16 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-D0639 Reactive Brown 23
Reactive Brown 23 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-D0661 Reactive red 45
Reactive red 45 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.
Fluorescent Dye  
/
HY-W653999 Glycodeoxycholic acid-d5
Glycodeoxycholic acid-d5 is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
Isotope-Labeled Compounds   Autophagy   STAT   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-D2227 IR-58
IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway.
Autophagy   Apoptosis  
Cancer  
/
HY-32350S1 Ercalcitriol-d3
Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases.
Isotope-Labeled Compounds   VD/VDR   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W776847 3-(2-Iodoacetamido)-proxyl
3-(2-Iodoacetamido)-proxyl serves as a free radical spin probe employed in spin labeling techniques, which facilitate the exploration of the dynamic interactions among molecules, proteins, lipids, and cell membranes.
Fluorescent Dye  
/
HY-W096997A Sodium octyl sulfate (SOS), 95%
Sodium octyl sulfate (Sodium capryl sulfate; SOS), 95% is a medium-chain anionic surfactant. Sodium octyl sulfate (SOS), 95% exhibits strong hydrophobic interactions with serum albumins (such as human serum albumin HSA and bovine serum albumin BSA), but only weak interactions with other proteins including myoglobin and hemoglobin. Sodium octyl sulfate (SOS), 95% acts as an environmental pollutant in freshwater ecosystems, mimicking the interspecific pheromones released by *Daphnia magna* to induce the formation of multicellular colonies in green algae.
Biochemical Assay Reagents   Environmental Pollutants  
/
HY-W653896 Alternariol-d2
Alternariol-d2 is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.
Isotope-Labeled Compounds   Topoisomerase   Apoptosis   Androgen Receptor   Estrogen Receptor/ERR  
Infection  
/
HY-W748023 Cryptosporiopsin A
Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola.

Source: Cryptosporiopsis sp.strain CAFT122-1

Fungal  
Inflammation or Immune System Disease  
/
HY-N14856 Verlamelin
Verlamelin is a depsipeptide antibiotic. Verlamelin has anti-fungal activity against plant pathogens.
Antibiotic   Fungal  
Infection  
/
HY-P10425 T2857W
T2857W is a mutant peptide that has inhibitory effect on KIX-MLL interaction (IC50=5.67 μM). T2857W can be used for protein-protein interaction (PPI) and for the study of diseases related to KIX-MLL interaction, such as leukemia, cancer, etc.
Histone Methyltransferase  
Cancer  
/
HY-126604 Pyranonigrin A
Pyranonigrin A is isolated and identified from Penicillium brocae MA-231. Pyranonigrin A shows potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.

Source: Penicillium brocae MA-231

Others  
Infection  
/
HY-P2076A Dusquetide TFA
Dusquetide (SGX942) TFA is a first-in-class innate defense regulator (IDR). Dusquetide TFA modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide TFA shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns
p62   Bacterial  
Infection  
/
HY-B0015S1 Paclitaxel-d5 (benzoyloxy)
Paclitaxel-d5 (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
Isotope-Labeled Compounds   Microtubule/Tubulin   ADC Payloads   Apoptosis   Autophagy  
Cancer  
/
HY-144002 RIBI-529
RIBI-529 (RC-529) is a fully synthetic, low-toxicity TLR4 agonist vaccine adjuvant. RIBI-529 upregulates cell surface co-stimulatory molecules, receptors, cytokines and chemokines, and activates the innate immune system. RIBI-529 enhances short-term CD4+ T cell clonal expansion, division, and ex vivo survival under growth factor withdrawal conditions. RIBI-529 enhances humoral and cell-mediated adaptive immune responses, induces non-specific resistance against viral and bacterial pathogens, and skews responses toward a Th1 type, accompanied by Th2 responses.
Toll-like Receptor (TLR)   Interleukin Related  
Inflammation or Immune System Disease  
/
HY-B0272S1 Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
Bacterial   Influenza Virus   Antibiotic  
Infection  
/
HY-P2260C Tat-beclin 1 scrambled TFA
Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus.
HIV  
Infection  
/
HY-P11632 YLDLAPL
YLDLAPL is a sleep-enhancing peptide that can be isolated from truffle albumin hydrolysate. YLDLAPL exhibits sleep-promoting effects via regulation of lysosomal autophagy, neurological activity, tyrosine metabolism, and fatty acid elongation.
Autophagy  
Sleep-Wake Disorder  
/
HY-12222S1 Obeticholic acid-d4-1
Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.
FXR   Autophagy  
/
HY-P2266 SAH-EZH2
SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27.
Histone Methyltransferase  
Cancer  
/
HY-147889 BBR-BODIPY
BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins.
Apoptosis   Caspase   Bcl-2 Family  
/
HY-P10813 ZLIRTLHEWY
ZLIRTLHEWY is a potent peptide CD47/SIRPα interaction inhibitor. ZLIRTLHEWY is promising for research of cancers.
CD47  
Cancer   Inflammation or Immune System Disease  
/
HY-N12262 (+)-Epieudesmin
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen.
Bacterial  
Infection  
/
HY-D1056B2 Lipopolysaccharides, from Proteus mirabilis
Lipopolysaccharides, from Proteus mirabilis are lipopolysaccharide endotoxins and TLR-4 activators derived from Proteus mirabilis, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from Proteus mirabilis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Proteus mirabilis is a major pathogen causing urinary tract infections and may also contribute to rheumatoid arthritis. Lipopolysaccharides, from Proteus mirabilis also exhibit potential anti-tumor effects, demonstrating in vivo inhibitory activity against solid tumors such as meningosarcoma and Walker carcinosarcoma.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
/
HY-P5710 LCI peptide
LCI peptide is an antimicrobial peptide with antibacterial activity. LCI peptide is active against plant pathogens, Xanthomonas and Pseudomonas, including E. coli, Gentamicin-resistant MRSA and Xoo.
Bacterial  
Bacterial Infection  
/
HY-N4120 Valechlorine
Valechlorine, an iridoid, is an autophagy enhancer. Valechlorine is effective in alleviating fatty liver by acting as an autophagy enhancer to break down lipid droplets. Valechlorine can be used for the study of nonalcoholic fatty liver disease (NAFLD).
Autophagy  
/
HY-157922 Trehalose C12
Trehalose C12 (α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate) is a nonreducing disaccharide with amphiphilic property, which is used as emulsifier, surfactant, encapsulating materials, and in the biochemical researches of cellular processes and membrane interactions.
Biochemical Assay Reagents  
/
HY-P11633 YLRPEGDW
YLRPEGDW is an orally active sleep-promoting peptide. YLRPEGDW upregulates Autophagy-related genes, increase Autophagy activity. YLRPEGDW could improve Caffeine-induced sleep reduction.
Autophagy  
Sleep-Wake Disorder  
/
HY-P99709 Lodapolimab
Lodapolimab (LY3300054) is a fully human IgG1λ anti-PD-L1 monoclonal antibody, with an EC50 of 0.075 nM against hPD-L1 and an EC50 of 0.085 nM against cynomolgus monkey PD-L1. Lodapolimab induces naive T cell activation, enhances the T cell activation effect of anti-CTLA4 antibodies, promotes anti-tumor alloreactivity, regulates innate immune pathways, and induces characteristics of adaptive immune activation. Lodapolimab can be used in research related to high-grade serous ovarian cancer and other solid tumors.

Species: Human

PD-1/PD-L1  
Inflammation or Immune System Disease   Ovarian Cancer   Triple-Negative Breast Cancer  
/
HY-W020033R Lanosterol (Standard)
Lanosterol (Standard) is the analytical standard of Lanosterol. This product is intended for research and analytical applications. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases[1][2].
Reference Standards   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-P3709 TRAF6 peptide
TRAF6 peptide is a specific TRAF6-p62 inhibitor. TRAF6 peptide potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke.
p62   E1/E2/E3 Enzyme  
Neurological, Eye or Ear Disease  
/
HY-173150 Hapalindole Q
Hapalindole Q (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. Hapalindole Q binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. Hapalindole Q holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.).

Source: Hapalosiphon fontinalis

YAP  
Cancer  
/
HY-W020033S Lanosterol-d6
Lanosterol-d6 is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s
Isotope-Labeled Compounds   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-P10027 Clovibactin
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors.
Antibiotic   Bacterial  
Infection  
/
HY-B0272S Rifampicin-d3
Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
Bacterial   Influenza Virus   Antibiotic  
Infection  
/
HY-W008907 5'-O-Tritylthymidine
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.
Apoptosis  
Cancer   Digestive System Disease   Digestive System Inflammation  
/
HY-W836186 Cyclo(Leu-Ala)
Cyclo(Leu-Ala) (Cyclo(alanine-leucine)) is an antimicrobial compound isolated from microorganisms and has antimicrobial activity against some plant pathogens together with other compounds.
Bacterial  
/
HY-P11228 FPP29
FPP29 is a potent peptide-based FOXM1 PROTAC degrader. FPP29 induces ubiquitination and degradation of FOXM1. FPP29 inhibits FOXM1 via the ubiquitin-proteasome degradation pathway. FPP29 induces Apoptosis. FPP29 suppresses tumor growth in hepatocellular carcinoma xenograft models. FPP29 can be used in the research of hepatocellular carcinoma (cell-penetrating peptide: (HY-P0133); VHL ligase ligand: (HY-P11493); linker: (HY-W013664); FOXM1 ligand: (HY-P11494)).
PROTACs   FOXM1   Apoptosis   DNA/RNA Synthesis  
Liver Cancer  
/
HY-P3709A TRAF6 peptide TFA
TRAF6 peptide TFA is a specific TRAF6-p62 inhibitor. TRAF6 peptide TFA potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide TFA has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke.
p62   E1/E2/E3 Enzyme  
Neurological, Eye or Ear Disease  
/
HY-W145481A D-Galacto-D-mannan
D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease.
C-type Lectin-like Receptors (CTLRs)   Sirtuin  
Inflammation or Immune System Disease  
/
HY-P2320 IDR-1
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release.
Bacterial  
Inflammation or Immune System Disease  
/
HY-P99525 Varisacumab
Varisacumab (R 84; GNR-011) is a fully humanized IgG1 monoclonal antibody targeting VEGF. Varisacumab specifically blocks the interaction between VEGF and VEGFR2, but does not interfere with the interaction between VEGF and VEGFR1. Varisacumab achieves effective anti-tumor and anti-angiogenic effects and can be used in the research of non-small cell lung cancer and pancreatic cancer.

Species: Human

VEGFR  
Pancreatic Cancer   Non-Small Cell Lung Cancer  
/
HY-B1847S Terbuthylazine-d9
Terbuthylazine-d9 is the deuterium labeled Terbuthylazine (HY-B1847). Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein.
Isotope-Labeled Compounds   Herbicide   Acetolactate Synthase (ALS)  
/
HY-P990782 Efzofitimod
Efzofitimod is a splice variant of the aminoacyl-tRNA synthetase HARS1, which is fused with the Fc segment of a human antibody. Efzofitimod targets the neuronal phospholipid NRP2 (neuropilin-2) and has anti-inflammatory and immunomodulatory activities. Efzofitimod can downregulate the innate and adaptive immune responses in inflammatory disease states, suppressing indirect lung disease (ILD).

Species: Human

Aminoacyl-tRNA Synthetase  
Inflammation or Immune System Disease  
/
HY-B2123R Lactose (Standard)
Lactose (Standard) is the analytical standard of Lactose. This product is intended for research and analytical applications. Lactose is a β-galactoside consisting of galactose and glucose residues, the main carbohydrate in mammalian breast milk. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory functions.
Reference Standards   Endogenous Metabolite   Interleukin Related   ERK   NF-κB  
Inflammation or Immune System Disease  
/
HY-B1111S1 Amitraz-d3
Amitraz-d3 is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.
Isotope-Labeled Compounds   Adrenergic Receptor   Monoamine Oxidase   Parasite  
Infection   Metabolic or Endocrine Disease  
/
HY-P99928 Efprezimod alfa
Efprezimod alfa (MK 7110; CD24 Fc) is a humanized CD24-Fc fusion protein. Efprezimod alfa enhances the interaction between CD24 and Siglec-10, thereby regulating the response of innate immune cells to damage-associated molecular patterns, inhibiting the activation of antigen-presenting cells and subsequent inflammatory responses. Efprezimod alfa is applicable to the research of acute graft-versus-host disease and acquired immunodeficiency syndrome.
Transmembrane Glycoprotein  
Cancer  
/
HY-157353 MacConkey Agar
MacConkey Agar (MAC) can be used for selective isolation and culture of intestinal pathogens. The composition of 1 liter of MacConkey Agar (MAC) is: 20.0g peptone, 10.0 g lactose, 1.5 g Bile salt number three, 5.0 g sodium chloride, 0.03g Neutral red, 0.001 g Crystal viol and 15.0 g agar.
Biochemical Assay Reagents  
Cancer  
/
HY-B0272S2 Rifampicin-d4
Rifampicin-d4 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
Bacterial   Influenza Virus   Antibiotic  
Infection  
/
HY-N8418 Cearoin
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.
Autophagy   Reactive Oxygen Species (ROS)   ERK   Apoptosis  
Cancer  
/
HY-N8678 Thonningianin B
Thonningianin B is an antioxidant and an autophagy enhancer.
Free Radical Scavengers   Autophagy  
Neurological, Eye or Ear Disease  
/
HY-P5314 OK2
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research.
EGFR   STAT  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Hepatitis C Virus Infection   Obesity  
/
HY-P990845 Anti-Ganglioside GD2 Antibody (14G2a)
Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Ganglioside GD2. Anti-Ganglioside GD2 Antibody (14G2a) can induce neuroblastoma cells autophagy and lysis. Anti-Ganglioside GD2 Antibody (14G2a) can be used for the research of cancer, such as neuroblastoma.

Species: Human

Others  
Cancer  
/
HY-P99770 Omodenbamab
Omodenbamab is an anti-SpA (Staphylococcal protein A) human monoclonal antibody with a KD value of 0.0467 nM. Omodenbamab circumvents a key S. aureus evasion mechanism by targeting the cell wall moiety Protein A (SpA). Omodenbamab can be used in research of S. aureus bloodstream infection.

Species: Human

Bacterial  
Infection  
/
HY-W749867 Ca(II)-EDTA disodium dihydrate
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning.
Bacterial  
Bacterial Infection  
/
HY-P99484 Botensilimab
Botensilimab (AGEN 1181), a human anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer.

Species: Human

CTLA-4  
Non-Small Cell Lung Cancer  
/
HY-137884 3-Indolyl acetate
3-Indolyl acetate is an ester derivative of indole that is ubiquitous in various plant tissues, especially in certain cruciferous vegetables such as broccoli and cabbage. 3-Indolyl acetate has unique chemical properties that make it an important signaling molecule in plants, regulating various physiological processes such as growth and defense against pathogens. It also has potential applications in the pharmaceutical industry, as it has been shown to have antitumor and anti-inflammatory effects in some studies.
Biochemical Assay Reagents  
/
HY-101092A QS-21
QS-21 is a mixture of QS-21-Xyl (HY-101092B) and QS-21-Api (HY-101092), with a ratio of 35:65. QS-21 is an innate immune system-targeted adjuvant. QS-21 is promising for research of oncology vaccines (e.g., melanoma) and infectious disease vaccines (e.g., HIV, malaria).
Toll-like Receptor (TLR)  
Cancer   Infection  
/
HY-15206S1 Glyburide-d3
Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
Potassium Channel   Mitochondrial Metabolism   Autophagy   CFTR   P-glycoprotein  
Metabolic or Endocrine Disease  
/
HY-W010410 Oct-1-en-3-ol
Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling.
Environmental Pollutants  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-175552 CHIPOpt
CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research.
Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-159114 Whole Glucan Particles
Whole Glucan Particles is a Dectin-1a agonist. Whole Glucan Particles activates the innate immune system to improve the function of macrophages, monocytes and other immune cells.
C-type Lectin-like Receptors (CTLRs)   Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-N0610S1 trans-Cinnamic acid-d7
trans-Cinnamic acid-d7 is the deuterium labeled trans-Cinnamic acid. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1.
Bacterial   Endogenous Metabolite  
Infection  
/
HY-P99795 Otilimab
Otilimab (GSK 3196165) is an anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) human monoclonal antibody. Otilimab neutralises the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor.

Species: Human

c-Fms  
Inflammation or Immune System Disease  
/
HY-W020005 2-Carboxyphenol-d4
2-Carboxyphenol-d4 is the deuterium labeled 2-Carboxyphenol. 2-Carboxyphenol is a plant hormone and mediates host responses against microbial pathogens.
Isotope-Labeled Compounds  
/
HY-P2260B Tat-beclin 1 scrambled
Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus.
HIV  
Infection  
/
HY-NP0196 Mouse immunoglobulin G
Mouse Immunoglobulin G (Mouse IgG) is the most abundant glycoprotein in mouse serum, which bridges innate and adaptive immune responses. A conserved asparagine-297 residue on each heavy chain contains an N-linked glycosylation site. Mouse Immunoglobulin G shares many glycosylation features with human IgG, but contains N-Glycolylneuraminic acid (HY-128965) instead of N-acetylneuraminic acid (HY-I0400). Mouse Immunoglobulin G is widely used as a negative isotype control, immunoassay coating protein and research standard in the life sciences.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-N6714 Alternariol
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.

Source: fungi of the genus Alternaria

Topoisomerase   Androgen Receptor   Estrogen Receptor/ERR   Apoptosis  
Infection  
/
HY-P3151 Gliadin p31-43
Gliadin p31-43 is an undigested gliadin peptide. Gliadin p31-43 induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 can be used for celiac disease research.
Others  
Inflammation or Immune System Disease  
/
HY-P99791 Orilanolimab
Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity.

Species: Human

Others  
Inflammation or Immune System Disease  
/
HY-P99759 Nogapendekin alfa (his tag)
Nogapendekin alfa his tag is an immunostimulant that binds to the IL-2RβγC complex on immune cells. Nogapendekin alfa his tag stimulates the proliferation and activation of natural killer cells and CD8+ T cells, upregulates the expression of granzyme B and perforin, and activates the innate and adaptive immune branches. Nogapendekin alfa his tag forms ALT-803 with IL-15RαSuFc; this complex has an extended biological half-life, improved biodistribution and retention in lymphoid tissues, enhances natural killer cell-mediated rituximab-dependent cellular cytotoxicity, and reduces tumor burden and improves survival when combined with anti-CD20 monoclonal antibody therapy. Nogapendekin alfa his tag can be used in the research of non-Hodgkin's lymphoma.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease   Non-Hodgkin Lymphoma  
/
HY-P2076 Dusquetide
Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns
p62   Bacterial  
Infection  
/
HY-W145665 Amylose
Amylose is not a typical small-molecule ligand with a specific traditional receptor-binding target. It is a polysaccharide. In food science and biological systems, amylose can interact with proteins and free fatty acids through non-covalent forces like hydrophobic interactions and electrostatic interactions. For example, it can form a ternary complex with them, which is related to the structure and digestion of starch. It is widely studied in the fields of food science, carbohydrate metabolism, and is also relevant in research on controlling glycemic responses, as it affects starch digestion rate.
Biochemical Assay Reagents   Endogenous Metabolite  
/
HY-107202GL Polyinosinic-polycytidylic acid (GMP Like)
Polyinosinic-polycytidylic acid (Poly(I:C)) (GMP Like) is the GMP Like class Polyinosinic-polycytidylic acid (HY-107202), and can be used as pharmaceutical excipients. Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Inflammation or Immune System Disease  
/
HY-P991192 BI-1808
BI-1808 is a human IgG1 monoclonal antibody that targets TNFR2by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8+ T cells.

Species: Human

TNF Receptor  
Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-P10810 QPH-FR
QPH-FR is a LGR5 inhibitor. QPH-FR competitively binds to LGR5 and prevents the formation of the LGR5/RSPO1 complex. QPH-FR promotes RNF43/ZNRF3-mediated ubiquitination of FZD receptors, inhibits the Wnt β-catenin signaling pathway, and reduces the stemness of colorectal cancer cells. QPH-FR is applicable to relevant research on colorectal cancer.
Wnt   β-catenin  
Colorectal Cancer  
/
HY-141633 Sucrose monolaurate
Sucrose monolaurate is a glycolipid surfactant. Sucrose monolaurate interacts with bacterial DNA, disrupts cell membrane permeability, and exerts excellent inhibitory and bactericidal effects against a variety of foodborne pathogens (especially Gram-positive bacteria). Sucrose monolaurate significantly reduces liquid surface tension, and acts as a synergist for chlorine-based disinfectants in food cleaning and disinfection to improve the removal efficiency of pathogens on the surface of agricultural products.
Bacterial  
Bacterial Infection  
/
HY-N10159 1-Benzyl-I3C
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1.
E1/E2/E3 Enzyme  
Cancer  
/
HY-110228 Metformin-d6 hydrochloride
Metformin-d6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
Isotope-Labeled Compounds   AMPK   Autophagy   Mitophagy   Apoptosis   mTOR  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N8332 Bile extract
Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens.
Bacterial   DNA/RNA Synthesis  
Infection  
/
HY-15531S Venetoclax-d8
Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.
Bcl-2 Family   Autophagy  
Cancer  
/
HY-P99396 Spesolimab
Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-D0838 Dodecyltrimethylammonium bromide
Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.
Biochemical Assay Reagents  
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HY-P7620 ATG5 Protein, Human
ATG5 is an important participant in the formation of autophagy vesicles and binds to ATG12 through a ubiquitin-like system, which is critical for the lipidation of ATG8 family proteins. It plays a crucial role in mitochondrial quality control, affects cell longevity, and is critical for lymphocyte development, antigen processing, axonal morphology maintenance, adipocyte differentiation, primary ciliogenesis, and apoptotic processes. ATG5 Protein, Human is the recombinant human-derived ATG5 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

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HY-P703284 ATG7 Protein, Human (sf9)
ATG7 Protein, Human (sf9) is the recombinant human-derived ATG7, expressed by sf9 insect cells, with tag free labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P71576 ATG14 Protein, Human (Myc, His)
ATG14 is critical for basal and induced autophagy, determining PI3KC3-C1 localization, helping autophagosome formation and BECN1 translocation. It enhances PIK3C3 activity in a BECN1-dependent manner, which is essential for BECN1 phosphorylation. ATG14 Protein, Human (Myc, His) is the recombinant human-derived ATG14 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P7617 ATG3 Protein, Human
ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.

Species: Human; Source: E. coli

Ubiquitin Related Proteins Ubiquitin Enzymes E2 Enzymes Autophagy-Related Protein 3 (ATG3)

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HY-P701512 SMURF2 Protein, Human (His)
SMURF2 protein is an E3 ubiquitin protein ligase that interacts with SMAD7 to induce ubiquitin-dependent degradation of TGF-β receptors and downregulate TGF-β signaling. This interaction triggers autocatalytic degradation of SMURF2 and is antagonized by AIMP1. SMURF2 Protein, Human (His) is the recombinant human-derived SMURF2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Ubiquitin Related Proteins Transferases (EC 2) Ubiquitin Enzymes E3 Ligases

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HY-P71729 DCD Protein, Human (P.pastoris, His)
The DCD protein is found in sweat and has antimicrobial activity against Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Candida albicans. DCD Protein, Human (P.pastoris, His) is the recombinant human-derived DCD protein, expressed by P. pastoris , with N-6*His labeled tag.

Species: Human; Source: P. pastoris

Enzymes & Regulators Hydrolases (EC 3)

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HY-P7618 ATG4A Protein, Human (His)
ATG4A Protein, Human (His) is a recombinant human Autophagy Related 4 Homolog A (ATG4A) expressed in E. coli with a His tag. ATG4A, a member of a family of cysteine proteinases, is a autophagy-regulating protease.

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P7619 ATG4C Protein, Human (His)
ATG4C Protein, Human (His) is a recombinant human Autophagy Related 4 Homolog C (Atg4C) expressed in E. coli with a His tag. Atg4C, a member of a family of cysteine proteinases, is a autophagy-regulating protease.

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P78759 ELAPOR1 Protein, Human (sf9, His)
The ELAPOR1 protein emerged as a potential cytoprotective agent, inducing cytoplasmic vacuolation and upregulating the autophagy pathway to protect cells from death. ELAPOR1 interacts with HSPA5 and plays dual roles in apoptosis and cell proliferation. ELAPOR1 Protein, Human (sf9, His) is the recombinant human-derived ELAPOR1 protein, expressed by sf9 insect cells , with C-His labeled tag. The total length of ELAPOR1 Protein, Human (sf9, His) is 869 a.a., with molecular weight of 100-120 kDa.

Species: Human; Source: sf9 insect cells

Cytokines and Growth Factors

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HY-P701246 ATG10 Protein, Human (GST)
ATG10 Protein, Human (GST) is a recombinant human Autophagy Related 10 Homolog (ATG10) expressed in E. coli with a GST tag. ATG10 is an E2 ubiquitin-conjugating-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation.

Species: Human; Source: E. coli

Enzymes & Regulators Ubiquitin Related Proteins Transferases (EC 2) Ubiquitin Enzymes E2 Enzymes Autophagy-Related Protein 10 (ATG10)

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HY-P701513 SMURF2 Protein, Human
SMURF2 protein is an E3 ubiquitin protein ligase that interacts with SMAD7 to induce ubiquitin-dependent degradation of TGF-β receptors and downregulate TGF-β signaling. This interaction triggers autocatalytic degradation of SMURF2 and is antagonized by AIMP1. SMURF2 Protein, Human is the recombinant human-derived SMURF2 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Enzymes & Regulators Ubiquitin Related Proteins Transferases (EC 2) Ubiquitin Enzymes E3 Ligases

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HY-P703021 PRPF19 Protein, Human (sf9, GST)
PRPF19 Protein, Human (sf9, GST) is the recombinant human-derived PRPF19, expressed by Sf9 insect cells , with GST labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Transferases (EC 2)

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HY-P703352 ATG101 Protein, Human (sf9, His, Strep)
ATG101 Protein, Human (sf9, His, Strep) is the recombinant human-derived ATG101, expressed by sf9 insect cells, with Strep, His labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P705139 ELAPOR1 Protein, Human (Biotinylated, HEK293, His-Avi)
The ELAPOR1 protein emerged as a potential cytoprotective agent, inducing cytoplasmic vacuolation and upregulating the autophagy pathway to protect cells from death. ELAPOR1 interacts with HSPA5 and plays dual roles in apoptosis and cell proliferation. ELAPOR1, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ELAPOR1 protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Biotinylated Proteins

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HY-P80022 ATG5 Antibody (YA599)
ATG5 Antibody (YA599) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5.

Host: Rabbit; Reactivity: Human, Rat, Mouse, Monkey

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81905 ATG13 Antibody (YA1650)
ATG13 Antibody (YA1650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG13.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83336 ATG9A Antibody (YA3081)
ATG9A Antibody (YA3081) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG9A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87078 SMURF1 Antibody (YA6771)
SMURF1 Antibody (YA6771) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMURF1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80545 ATG5 Antibody (YA615)
ATG5 Antibody (YA615) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83313 PRPF19 Antibody (YA3058)
PRPF19 Antibody (YA3058) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRPF19.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80545A ATG5 Antibody (YA615)(PBS only)
ATG5 Antibody (YA615) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811985 RNF123 Antibody(YA10456)
RNF123 Antibody(YA10456) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RNF123.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811985A RNF123 Antibody(YA10456) (PBS only)
RNF123 Antibody(YA10456) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RNF123.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81236 ATG10 Antibody
ATG10 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ATG10.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

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HY-P81905A ATG13 Antibody (YA1650)(PBS only)
ATG13 Antibody (YA1650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG13.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86744 ATG5 Antibody (YA6436)
ATG5 Antibody (YA6436) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P86744A ATG5 Antibody (YA6436)(PBS only)
ATG5 Antibody (YA6436) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ATG5.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P86775 ATG12 Antibody (YA6468)
ATG12 Antibody (YA6468) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG12.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87136 Ube4A Antibody (YA6829)
Ube4A Antibody (YA6829) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ube4A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-K3120 Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads)

MCE Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads) utilizes a magnetic bead-based method for the isolation and purification of exosomes. The underlying principle is based on the charge-dependent interaction between exosomes and functional polymers on the surface of the magnetic beads under an optimized buffer system, enabling selective adsorption of exosomes. Subsequent adjustment of the ionic strength and pH of the buffer promotes the gentle dissociation of exosomes from the magnetic beads, thereby enabling efficient exosome isolation and purification while maintaining high vesicle integrity and low impurity carryover.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-KD1004A Vari Fluor 4-colour Multiple Fluorescent Staining Kit-1 (For all samples)
Multiplex immunohistochemistry is also known as Tyramide Signal Amplification (TSA, Tyramide dignal amplification). It has been used for more than 20 years as an enzymatic assay for high-density in situ labelling of target proteins or nucleic acids by horseradish peroxidase (HRP). The method is based on multiple cis-immunostaining with tyramide signal amplification, which allows the detection of multiple target sites in cell or tissue samples in situ, and elucidation of their interaction mechanism through the study of the combination and positional relationship of these target sites.

Protein Biology Multiple Fluorescent Staining

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Keywords

ubiquitination | autophagy | xenophagy | host-pathogen interactions | innate immunity | pathogen evasion