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GlycoRNAs Regulate Inflammation And Cancer Development

Intercellular Communication & Diseases Tumor Microenvironment Chronic Inflammation Proteostasis

GlycoRNAs are an emerging class of small noncoding RNAs covalently modified with glycans and displayed at the cell surface. Their discovery expands glycosylation biology beyond proteins and lipids and places RNA at a membrane interface where immune cells inspect glycans. Current models indicate that selected small RNAs enter canonical glycosylation and secretory pathways and carry sialylated or fucosylated structures. Cell-surface localization creates opportunities for interaction with selectins and sialic-acid-binding immunoglobulin-like lectins, or Siglecs, which regulate leukocyte adhesion and inhibitory signaling. These properties make glycoRNAs plausible participants in intercellular communication, inflammation, and cancer. Yet the field began only recently, and much of the mechanistic and disease literature remains descriptive or preclinical[1][2][3].

Immune effects may depend on the intact glycan-RNA structure. Sialylated glycans can engage inhibitory Siglecs on immune cells and potentially restrain activation; in a tumor context, increased presentation could contribute to immune escape. Conversely, partial glycan removal may expose modified nucleosides that are recognized by Toll-like receptors, creating a possible switch from inhibitory glycan recognition to innate inflammatory sensing. Selectin interactions may influence trafficking or cell-cell contact. These models are biologically coherent but should not be collapsed into a single universal function, because RNA sequence, glycan composition, surface density, carrier cell, and receptor repertoire all vary. Direct evidence connecting a defined endogenous glycoRNA structure to a disease phenotype is still limited, particularly in humans. Such work will clarify whether reported disease differences reflect a defined molecular species rather than differences in labeling efficiency, cell viability, or sample handling[1][2][4][5].

Cancer adds metabolic and microenvironmental complexity. Tumor cells can reprogram glycolysis and nucleotide-sugar metabolism, potentially changing substrates such as UDP-GlcNAc that support glycosylation. Altered glycoRNA abundance has been proposed to influence immune recognition, migration, invasion, or adaptation to stressful metastatic niches. Cell-surface stability and possible release into circulation also raise interest in liquid-biopsy biomarkers. However, low abundance, structural heterogeneity, incomplete knowledge of biosynthesis and anchoring, and the risk of confusing RNA-protein or RNA-lipid complexes with covalent glycoRNA complicate interpretation. Detection commonly combines metabolic labeling, click chemistry, imaging, RNA sequencing, mass spectrometry, and glycan-binding assays; orthogonal validation is essential because no single method establishes identity, structure, location, and function simultaneously. Potential interventions include blocking a disease-specific glycan-lectin interaction, changing glycoRNA biosynthesis or surface anchoring, targeted degradation, or using a stable glycoRNA signature as a biomarker. Safety is a central concern because shared glycosylation enzymes and Siglecs regulate many normal immune processes[1][2][3][4][5].

Translation will require structure-resolved maps of glycoRNA species in normal and diseased tissues, identification of the enzymes and trafficking machinery that create them, and causal perturbations that preserve unrelated glycoproteins and glycolipids. Patient studies should connect a measured structure to receptor engagement, immune-cell behavior, tumor state, and outcome. GlycoRNAs are therefore promising mechanistic and drug-discovery candidates, but claims that they regulate clinical inflammation or cancer development should remain proportional to a young and rapidly evolving evidence base. Standards should include synthetic or purified structural references, rigorous nuclease and glycosidase controls, and blinded replication across laboratories. Additional structural confirmation remains important across independent laboratories[1][2][4].

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Cat. No. Product Name Information Application Publication
HY-17589 Chloroquine phosphate
Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
Parasite   Autophagy   SARS-CoV   Toll-like Receptor (TLR)   HIV   Antibiotic  
Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   SARS-CoV-2 Infection   Rheumatoid Arthritis  
1304
HY-17589A Chloroquine
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
Parasite   Autophagy   SARS-CoV   Toll-like Receptor (TLR)   HIV   Antibiotic  
Breast Cancer   Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   SARS-CoV-2 Infection   Rheumatoid Arthritis  
1304
HY-D1056 Lipopolysaccharides, from E. coli O55:B5
Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

Source: surface of Gram-negative bacteria

Toll-like Receptor (TLR)  
Cancer   Pain   Autoimmune Disease   Escherichia Coli Infection  
582
HY-11109 Resatorvid
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.
Toll-like Receptor (TLR)   TNF Receptor   Interleukin Related   Autophagy  
Prostate Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
524
HY-13740 Resiquimod
Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
Toll-like Receptor (TLR)   HCV  
Prostate Cancer   Viral Infection   Depression   Pain   Autoimmune Disease   SARS-CoV-2 Infection   Hepatitis C Virus Infection  
116
HY-L025 Anti-Cancer Compound Library
Cancer is the second leading cause of death globally and seriously threatens human health. A neoplasm and malignant tumor are other common names for cancer. Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Target therapy, which targets proteins that control how cancer cells grow, divide and spread, plays an important role in cancer treatment. Recent studies mainly focus on targeting the key proteins for cancer surviving, cancer stem cells, the tumor microenvironment, tumor immunology, etc. MCE designs a unique collection of 11,167 anti-cancer compounds that target kinases, cell cycle key components, tumorigenesis related signaling pathways, etc. MCE Anti-cancer compound library is a useful tool for anti-cancer drug screening.

Disease Focused Libraries

99
HY-L006 GPCR/G Protein Compound Library
GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery. MCE provides a unique collection of 3,479 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

Signaling Pathway Targeting Libraries

93
HY-W031727 Hydroxychloroquine
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling.
Parasite   Toll-like Receptor (TLR)   SARS-CoV   Autophagy  
Prostate Cancer   Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   Rheumatoid Arthritis  
91
HY-L011 Membrane Transporter/Ion Channel Compound Library
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 2,261 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

90
HY-L015 PI3K/Akt/mTOR Compound Library
The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials. MCE owns a unique collection of 1,125 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

Signaling Pathway Targeting Libraries

90
HY-L044 Nucleotide Compound Library
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications. MCE offers a unique collection of 586 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Structure Classified Libraries

89
HY-L134 Anti-Aging Natural Product Library
Aging is an unavoidable process, leading to cell senescence due to physiochemical changes in an organism. Aging cells cease to divide and drive the progression of illness through various pathways, resulting in the death of an organism ultimately. Anti-aging activities are primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. Natural products are known as effective molecules in anti-aging treatments, which delay the aging process through influencing several pathways and thus ensure an extended lifespan. MCE offers a unique collection of 193 natural products with validated anti-aging activity. MCE anti-aging natural product library is a useful tool for the study of aging-related diseases drugs and pharmacology.

Natural Product Screening Libraries Disease Focused Libraries

85
HY-L080 Targeted Therapy Drug Library
Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecular targets that are involved in the growth, progression, and spread of cancer. There are several different types of targeted therapy. The most common types are small-molecule drugs and monoclonal antibodies. Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells, while monoclonal antibodies are usually used for targets that are located outside the cells. Because of high specificity, low side effect and potent anticancer activity, targeted therapy has become the mainstream of new anti-tumor drugs. Various targeted therapies have been approved by FDA and used in the treatment of diseases. MCE carefully collects a unique of 108 targeted therapy drugs used in cancer treatment. MCE Targeted therapy drug library is a useful tool for the research of targeted therapy.

Disease Focused Libraries

84
HY-L0116V Asinex Macrocycles for RNA Library
Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
83
HY-L072 Exosomes Compound Library
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells in culture. Exosomes contain nucleic acids, proteins, lipids, amino acids, and metabolites, etc. Their diverse constituents can reflect their cell of origin. Exosomes are associated with immune responses, viral pathogenicity, pregnancy, cardiovascular diseases, central nervous system-related diseases, and cancer progression. Proteins, metabolites, and nucleic acids delivered by exosomes into recipient cells effectively alter their biological response. Such exosome-mediated responses can be disease promoting or restraining. The biology of exosomes in disease is still emerging, and the number of studies addressing their utility in the diagnosis and treatment of various pathologies has increased substantially. MCE supplies a unique collection of 56 compounds with the activity of inhibiting or stimulating exsomes secretion/biosynthesis. MCE Exosomes Compound Library is a useful tool for exsomes research.

Signaling Pathway Targeting Libraries

83
HY-L073 Anti-Hepatitis C Virus Compound Library
Hepatitis C virus (HCV) is a hepatotropic enveloped positive- strand RNA virus (family Flaviviridae) that infects the parenchymal cells of the liver. HCV infection is a significant public health burden. Globally, an estimated 71 million people have chronic hepatitis C virus infection. A significant number of those who are chronically infected will develop cirrhosis or liver cancer. To date, there is no vaccine against HCV, and combination pegylated alpha interferon (pIFN-) and ribavirin, the main standard-of-care treatment for HCV, is effective in only a subset of patients and is associated with a wide spectrum of toxic side effects and complications. More recently, new therapeutic approaches that target essential components of the HCV life cycle have been developed, including direct-acting antiviral (DAA) that specifically block a viral enzyme or functional protein and host-targeted agents (HTA) that block interactions between host proteins and viral components that are essential to the viral life cycle. However, the genetic diversity of HCV viruses and the stage of liver disease (i.e., cirrhosis) are revealing themselves as obstacles for effective, pan-genotypic treatments. There still exists a need for the discovery and development of new HCV inhibitors. In particular, since the future of HCV therapy will likely consist of a cocktail approach using multiple inhibitors that target different steps of infection, new antivirals targeting all steps of the viral infection cycle. MCE offers a unique collection of 395 compounds with identified and potential anti-HCV activity. MCE Anti- Hepatitis C Virus Compound Library is a useful tool for discovery new anti-HCV drugs and other anti-infection research.

Disease Focused Libraries

83
HY-L103 Anti-Colorectal Cancer Compound Library
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer. Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 2,611 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

Disease Focused Libraries

83
HY-L124 Anti-Prostate Cancer Compound Library
Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment. MCE offers a unique collection of 3,586 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

Disease Focused Libraries

83
HY-L148 TCA Cycle Compound Library
The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins. For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future. MCE supplies a unique collection of 72 compounds related to the TCA cycle. MCE TCA Cycle Compound Library is a useful tool for the TCA cycle related research and anti-cancer drug development.

Signaling Pathway Targeting Libraries

83
HY-L150 Membrane Receptor-targeted Compound Library
Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules. There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery. MCE provides a unique collection of 7,077 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

83
HY-L155 Mitochondrial Toxicity Compound Library
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 542 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Compound Characteristic Classified Libraries Signaling Pathway Targeting Libraries

83
HY-L156 Autoimmune Disease Compound Library
Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A). MCE designs a unique collection of 1,021 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Disease Focused Libraries

83
HY-L175 Inflammasomes related Compound Library
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 176 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L179 Radiosensitizer Library
Radiotherapy is a common treatment for various cancers, and more than 50% of cancer patients require radiotherapy during the disease treatment. With advances in radiation technology and a better understanding of tumor biology, the efficacy of radiation therapy has gradually improved, and more and more patients have benefited from it. However, even with the use of advanced radiotherapy techniques, there are still many malignant tumor cells with low sensitivity to radiation, leading to the radiation effect is not ideal. To solve this problem, radiosensitizers have received more and more attention. Radiosensitizer is a kind of drug that can enhance the radiosensitivity of tumor cells and improve the effect of radiotherapy. Radiation sensitizers act in a variety of ways, such as killing hypoxic cells, enhancing DNA damage, inhibiting DNA damage repair, and blocking cell cycle progression, making tumor cells more susceptible to radiation damage and death than surrounding normal cells. MCE designs a unique collection of 40 compounds with definite reported radiosensitization. It can be used for drug combination research in anti-cancer treatment.

Compound Characteristic Classified Libraries

83
HY-L211 Human Hormone Compound Library
Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases. MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.
83
HY-L231 TCA Cycle Metabolite Compound Library
The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins. For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future. MCE supplies a unique collection of 25 key intermediates of the TCA cycle, which can be utilized for TCA-related research and metabolomics identification studies.
83
HY-L237 Pattern Recognition Receptors Library
Pattern Recognition Receptors (PRRs) are a crucial class of protein molecules expressed in cells of the innate immune system. The core function of Pattern Recognition Receptors is to recognize Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs). Upon recognizing and binding to PAMPs or DAMPs, PRRs rapidly initiate intracellular signaling pathways (such as the NF-κB, IRF, and inflammasome pathways). This triggers the production of inflammatory factors, chemokines, and type I interferons, thereby initiating inflammatory responses to eliminate pathogens or repair damage. PRRs represent the body's first line of defense against infection, and the rapidity and broad specificity of their response are crucial for host survival. However, aberrant activation of PRR signaling is also a cause of many chronic inflammatory diseases, autoimmune disorders, and neurodegenerative diseases. Therefore, precisely regulating PRR activity has become a key therapeutic strategy for these conditions. MCE has cataloged 337 inhibitors targeting key PRRs, such as NLRs, TLRs, C-type Lectin Receptors (CLRs), and cGAS, to support drug discovery efforts for chronic inflammatory diseases.
83
HY-L248 RNA Binding Bioactive Compound Library
The RNA-targeted bioactive compound library is a high-quality collection of small molecules specifically designed and curated to target RNA structures and functions. It is widely applied in cutting-edge drug discovery and life science research. Unlike traditional strategies that focus on protein targets, RNA-targeted compounds can directly modulate various functional RNA molecules by influencing their splicing, translation, stability, or structural conformation, thereby enabling precise intervention in key biological processes. In the field of drug development, these compounds provide a novel approach to addressing previously “undruggable” targets and have demonstrated significant potential in areas such as oncology, antiviral therapies, and neurodegenerative diseases. For example, by targeting disease-associated RNA structural domains or regulating the aberrant expression of non-coding RNAs, these compounds can effectively inhibit disease progression or restore normal cellular function. In mechanistic studies, RNA-targeted compounds serve as valuable chemical biology tools to elucidate the roles of RNA in gene expression regulation, cellular signaling pathways, and disease development. The MCE RNA-targeted bioactive compound library contains 860 compounds, sourced from databases such as TargetRX Atlas and R-BIND. The library features excellent structural diversity and biological activity, making it suitable for high-throughput screening (HTS), target validation, phenotypic screening, and lead compound discovery. It represents a valuable resource for RNA-related research and innovative drug development.

Signaling Pathway Targeting Libraries

83
HY-L917 RNA Binding Library
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs. MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.

Focused and target libraries

83
HY-135748 Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   Apoptosis  
Cancer   Digestive System Disease   Pain   Autoimmune Disease   Digestive System Inflammation   Lung Fibrosis  
71
HY-107202 Polyinosinic-polycytidylic acid
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Digestive System Disease   Prostate Cancer   Pain   Digestive System Inflammation   Lung Fibrosis   Rheumatoid Arthritis  
70
HY-B0180 Imiquimod
Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19.
Toll-like Receptor (TLR)   Autophagy   SARS-CoV   HSV  
Inflammation or Immune System Disease   Metastatic Breast Cancer   SARS-CoV-2 Infection  
60
HY-153808 Complete Freund's adjuvant (CFA)
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
22
HY-W854659 Chlorin e6 trisodium
Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions.
Photosensitizer  
Cancer  
20
HY-129389 Benzyl-α-GalNAc
Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-Fluorouracil (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation.
Glycosyltransferase  
Pancreatic Cancer  
13
HY-107780A Cyclic-di-GMP sodium
Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research.

Source: bacterial species

STING   Endogenous Metabolite  
9
HY-107780 Cyclic-di-GMP
Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research.

Source: bacterial species

STING   Endogenous Metabolite  
9
HY-107780B Cyclic-di-GMP diammonium
Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research.
STING   Endogenous Metabolite  
Cancer   Bacterial Infection  
9
HY-110382 Cyclic-di-GMP disodium
Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
STING   Endogenous Metabolite  
9
HY-148596 UDP-GlcNAc
UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y14 receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections.
P2Y Receptor   Glycosyltransferase   Drug Intermediate   Endogenous Metabolite  
Bacterial Infection  
8
HY-B0158 Cytidine
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.

Source: Widespread

Nucleoside Antimetabolite/Analog   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Lung Cancer   Leukemia/Lymphoma/Myeloma   SARS-CoV-2 Infection  
8
HY-111496 Sulfo-NHS-SS-Biotin sodium
Sulfo-NHS-SS-biotin sodium is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin sodium can be used for the labeling and purifying of cell-surface protein.
Biochemical Assay Reagents  
7
HY-110288 3FAx-Neu5Ac
3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X.
Sialyltransferase  
Metabolic or Endocrine Disease  
5
HY-139056 SU0268
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
Glycosyltransferase  
Cancer   Infection   Inflammation or Immune System Disease   Lung Fibrosis  
4
HY-112415 Lith-O-Asp
Lith-O-Asp is a sialytransferase (ST) inhibitor, with IC50s of 12-37 μM.
Sialyltransferase  
Metabolic or Endocrine Disease  
4
HY-P99176 ATG-031
ATG-031 is a humanized anti-CD24 monoclonal antibody with high affinity and specificity. ATG-031 interacts with Siglec-10 expressed by tumor-associated macrophages. ATG-031 effectively stimulates macrophage-mediated phagocytosis and induces cancer cell destruction by blocking the anti-phagocytic surface proteins. ATG-031 can be used in the study of haematological malignancies as well as solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Species: Human

Others  
Leukemia/Lymphoma/Myeloma  
4
HY-157646 MZ-101
MZ-101 (GYS1-IN-2) is an orally active, potent and selective small-molecule glycogen synthase 1 (GYS1) inhibitor with with an IC50 value of 0.041 µM. MZ-101 reduces glycogen concentrations in cells and in mice. MZ-101 can used to study GYS1 -mediated Pompe disease and other glycogen storage diseases.
Glycosyltransferase  
Metabolic or Endocrine Disease  
4
HY-W096600 2F-Peracetyl-Fucose
2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) acts as a potent fucosyltransferase (FUT) inhibitor.
Glycosyltransferase  
Cancer  
4
HY-102022 α-Galactosylceramide
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor).
Transmembrane Glycoprotein   Interleukin Related   CD1  
Inflammation or Immune System Disease  
4
HY-P99042 Polatuzumab
Polatuzumab is a monoclonal antibody that targets CD79b on the surface of B cells. Polatuzumab can be used to synthesize the ADC Polatuzumab Vedotin (HY-132253), which has anti-tumor activity.

Species: Human

Transmembrane Glycoprotein   ADC Antibodies  
CNS Neoplasm   Non-Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
3
HY-116705 2-Deoxy-2-fluoro-L-fucose
2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma.
Glycosyltransferase  
Cancer  
3
HY-P99126 Anti-Mouse/Human CD44 Antibody (IM7)
Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody that recognizes a conserved epitope outside the HA-binding domain of the CD44 molecule. Anti-Mouse/Human CD44 Antibody (IM7) exerts a potent anti-inflammatory effect by inducing the shedding of cell surface CD44, significantly improving symptoms in mice with rheumatoid arthritis without affecting relevant immune responses. Anti-Mouse/Human CD44 Antibody (IM7) can be used for researches on inflammation conditions and cancer such as arthritis and osteosarcoma.

Species: Human/Mouse

Transmembrane Glycoprotein   CD44  
Cancer   Inflammation or Immune System Disease   Arthritis  
3
HY-KE7055 RNase R

RNase R is a magnesium ion-dependent 3'-5' exoribonuclease that can increase the abundance of circular RNA by degrading linear RNA in mixed RNA, thereby enriching circular RNA.

Molecular Biology Restriction Endonuclease

3
HY-122524 7-Methylguanosine
7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
Nucleoside Antimetabolite/Analog   Endogenous Metabolite   DNA/RNA Synthesis  
Lung Cancer   Leukemia/Lymphoma/Myeloma  
2
HY-107366 SGN-2FF
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity.
Glycosyltransferase  
Leukemia/Lymphoma/Myeloma  
2
HY-P9981 Tafasitamab
Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19.

Species: Human

Apoptosis  
Cancer   Inflammation or Immune System Disease  
2
HY-P4910 Baceridin
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research.
Proteasome   Apoptosis  
1
HY-N7068 Mupirocin calcium hydrate
Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.

Source: Pseudomonas fluorescens

Bacterial   Antibiotic  
Inflammation or Immune System Disease   Pancreatic Cancer   Viral Infection   Bacterial Infection  
1
HY-P10387A RSM3 TFA
RSM3 TFA is a METTL3-METTL14 complex inhibitor with a Kd of 3.10 μM for the METTL3-METTL14 complex. RSM3 TFA reduces the m6A modification level of SLC31A1 and the global RNA methylation level. RSM3 TFA upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 TFA is applicable to the research of preeclampsia and cancer.
METTL3   Apoptosis  
Cancer  
1
HY-P3443 Peanut agglutinin
Peanut agglutinin (PNA) is a carbohydrate-recognition protein that binds competitively and irreversibly to cell-surface β-D-Gal (1-3)-GalNAc, and this binding can be inhibited by D-galactose and asialofetuin. Peanut agglutinin recognizes exposed glycoepitopes and reflects the glycosylation status of cells. Peanut agglutinin can label glycoconjugates at neuromuscular junctions to safely visualize synaptic structures. Peanut agglutinin can be used to synthesize dyes to distinguish between normal and tumor tissues. Peanut agglutinin provides support for research on leukemia, Burkitt's tumors, and cutaneous squamous lesions.
Biochemical Assay Reagents  
Leukemia/Lymphoma/Myeloma  
1
HY-N0093 Ancitabine hydrochloride
Ancitabine (Cyclocytidine) hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer.
Autophagy   CMV   DNA/RNA Synthesis   Orthopoxvirus  
Colorectal Cancer   Viral Infection  
1
HY-W073524 DFAME
DFAME is a red fluorophore (Ex = 508 nm, Em = 641 nm). DFAME binds to Beetroot and Corn (dimeric fluorescent RNA aptamers) to form Beetroot-DFAME (Kd = 460 nM) and Corn-DFAME (Kd = 3600 nM). Beetroot-DFAME and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research.
Fluorescent Dye  
1
HY-113138 3-Methyluridine
3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-125474 Carrageenan
Carrageenan is an antiviral and anticancer agent. Carrageenan inhibits herpes simplex virus (HSV), HIV, and hepatitis A virus (HAV) by directly binding to the viral capsid to block the attachment of viruses such as HPV to HSPG factors on the cell surface. Carrageenan delays and arrests cell cycle progression, exhibits cytotoxicity against HeLa cancer cells, and can be applied to studies related to cervical cancer, genital warts, hepatitis A, and other conditions. Carrageenan also induces acute non-immune inflammation, triggers a three-phase inflammatory response involving the release of multiple proinflammatory mediators, and causes persistent edema, hyperalgesia, and neutrophil recruitment in mice.
Environmental Pollutants   HSV   HIV  
Cervical Cancer   HIV Infection   Hepatitis Virus Infection   HSV Infection  
1
HY-P2988 Neuraminidase, Microorganism
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection.
Sialyltransferase  
Infection  
1
HY-P0251 Neurotensin(8-13)
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
Neurotensin Receptor  
Neurological, Eye or Ear Disease  
1
HY-132253 Polatuzumab vedotin
Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. The antibody portion is Polatuzumab (HY-P99042), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL).
Antibody-Drug Conjugates (ADCs)   Transmembrane Glycoprotein  
Leukemia/Lymphoma/Myeloma  
1
HY-Y1089 4-Dimethylaminopyridine
4-Dimethylaminopyridine is an acyl transfer catalyst. 4-Dimethylaminopyridine is used for labeling and analysis of glycoproteins on the surface of living cells. 4-Dimethylaminopyridine reduces dyskinesia attacks.
Biochemical Assay Reagents   Transmembrane Glycoprotein  
Neurological, Eye or Ear Disease  
1
HY-K2023 In vivo OptiLNP RNA Transfection Reagent (Local Effect)

MCE In vivo OptiLNP RNA Transfection Reagent (Local Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions locally.

Cell Biology Cell Culture Cell Transfection

1
HY-KE7058 RNase H

RNase H is an endoribonuclease expressed and purified from Escherichia coli and can specifically hydrolyze RNA in DNA-RNA hybrid strands.

Molecular Biology Restriction Endonuclease

1
HY-110382S Cyclic-di-GMP-13C20,15N10 disodium
13C20,15N10-Cyclic di-GMP (13C20,15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
Isotope-Labeled Compounds   STING   Endogenous Metabolite  
Cancer  
/
HY-P11710 Phos-FLAG
Phos-FLAG is a phosphorylated FLAG peptide. Phos-FLAG can undergo a Staudinger-like linkage reaction with azide groups metabolized into cell surface glycans and organ glycoproteins, enabling quantitative analysis of the presence of cell surface azides. Phos-FLAG can detect azide-labeled glycans in isolated cell and organ lysates.
Others  
/
HY-142999 DOIC
DOIC is a cationic lipid that can be used for RNA vaccines.
Liposome  
Inflammation or Immune System Disease  
/
HY-B0421S2 Mycophenolic acid-13C17
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
Isotope-Labeled Compounds   Flavivirus  
/
HY-P4027 HCV-1 e2 Protein (554-569)
HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2.
HCV  
Infection  
/
HY-P2115 Ramorelix
Ramorelix is a luteinizing-hormone-releasing hormone (LHRH) antagonist. Ramorelix can inhibit tumor progression in vivo. Ramorelix can be studied in anti-cancer research.
GnRH Receptor  
Cancer  
/
HY-P4523 FA-Ala-Arg
FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-10241S Simeprevir-13C,d3
Simeprevir-13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.
Isotope-Labeled Compounds   HCV   HCV Protease   SARS-CoV   DNA/RNA Synthesis  
SARS-CoV-2 Infection  
/
HY-P11052 A8 peptide
A8 peptide is a Hsp72 antagonist. A8 peptide inhibits tumor progression and metastasis as well as enhances the cancer cells' sensitivity to apoptosis induced by chemotherapeutic agents (such as Cisplatin (HY-17394)) by blocking the Hsp72-TLR2 interaction and the subsequent activation of MDSCs. A8 peptide can be used for cancers research.
HSP  
/
HY-D3387 TBI
TBI is a fluorescence enhancer with a Kd of 71 nM for the Broccoli fluorogenic RNA aptamer. TBI binds to the Broccoli fluorogenic RNA aptamer to activate its fluorescence.TBI undergoes photobleaching of its trans form, which dissociates rapidly, while cis-TBI from the media replaces the dissociated fluorophore to enable fluorophore recycling.TBI enables enhanced fluorescence of Broccoli during continuous cellular imaging (Ex/Em = 485/527 nm).
Fluorescent Dye  
/
HY-NP0194B C1q Protein (rabbit)
C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease.
Complement System  
Inflammation or Immune System Disease  
/
HY-P4552 Hippuryl-Phe-Arg-OH
Hippuryl-Phe-Arg-OH is the active site on the cell surface of Angiotensin I converting enzyme (ACE).
Angiotensin Receptor  
/
HY-158467 Core 1 O-glycan (C1), 2AB labelled
Core 1 O-glycan (C1), 2AB labeled is a 2AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-D1598 Sulfo-CY3 tetrazine potassium
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates. Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Fluorescent Dye  
/
HY-P2413 Ac-PPPHPHARIK-NH2
Ac-PPPHPHARIK-NH2 (compound S1) is a compound that inhibits the interaction between androgen receptor and Src. It can inhibit the binding of androgen or estrogen-induced receptor and Src in cancer cells, as well as the activation of related signaling pathways, and can also inhibit cell cycle progression and tumor growth.
Androgen Receptor   Src  
/
HY-P4027A HCV-1 e2 Protein (554-569) TFA
HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2.
HCV  
Infection  
/
HY-P10427 DV1
DV1 is a CXCR4 inhibitor with anti-proteolytic properties that specifically blocks the binding of SDF-1α to its receptor. DV1 inhibits the migration of breast cancer cells and enables the targeted delivery of avidin-PLGA nanoparticles to CXCR4-expressing cancer cells. DV1 not only effectively suppresses the progression of metastatic breast cancer in mouse models, but also preferentially accumulates in brain tumor tissues rather than normal brain tissues, showing potential for inhibiting intracranial tumor metastasis. As a humoral immune stimulant, DV1 induces the production of specific IgG, neutralizing antibodies and cellular immune responses, thereby providing the host with protection against lethal challenges. DV1 has been applied to studies on CXCR4-expressing cancers, glioblastoma, dengue fever and other related diseases.
CXCR   Dengue Virus  
Immunomodulation   Metastatic Breast Cancer   Hepatitis B Virus Related Hepatocellular Carcinoma   Glioblastoma  
/
HY-D1409 DMTr-4'-F-U-CED-TBDMS phosphoramidite
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure.
DNA Stain   Phosphoramidites  
Blood or Cardio-cerebrovascular Disease  
/
HY-P992366 HFB200901
HFB200901 is a galectin LGALS9 inhibitor and immunostimulant that can be used in studies related to pancreatic adenocarcinoma, pancreatic intraepithelial neoplasia, KRASG12C-mutant colon cancer, and prostate cancer. HFB200901 disrupts the LGALS9/TIM-3 axis, while blocking the internalization and vacuolization of recombinant LGALS9. HFB200901 reduces the proportion of regulatory T cells (Treg) and enhances dendritic cell activation, thereby inducing polyfunctional and memory CD8+ T cell responses. HFB200901 inhibits the progression of pancreatic neoplastic lesions and effectively improves the efficacy of PSMA-based vaccination.

Species: Human

Galectin   Tim3  
Prostate Cancer  
/
HY-W142432S Perfluoroundecanoic acid-13C7
Perfluoroundecanoic acid-13C7 is the 13C-labeled Perfluoroundecanoic acid (HY-W142432). Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation.
Autophagy   Isotope-Labeled Compounds   Arginase   Akt   p62   Wnt   mTOR   Atg8/LC3   β-catenin   TGF-beta/Smad   ERK  
/
HY-W759219 Adrenosterone-13C3
Adrenosterone-13C3 ((+)-Adrenosterone-13C3) is the 13C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.
Isotope-Labeled Compounds   Androgen Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P10295 p53 (232-240)
p53 (232-240) is a peptide segment of the 232-240 amino acid sequence of the human tumor suppressor protein p53. p53 (232-240) enhances its binding affinity to the Major histocompatibility complex (MHC), thereby enhancing the immunogenicity of this peptide to enhance the immune system's response to tumor antigens. p53 (232-240) can be used in the development of cancer vaccines and in the study of tumor cell recognition and clearance by the immune system.
MDM-2/p53  
/
HY-P990506 Anti-Siglec-2/CD22 Antibody (NCI m971)
Anti-Siglec-2/CD22 Antibody (NCI m971) is a humanized antibody expressed in CHO cells that targets Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (NCI m971) features a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.64 kDa. The isotype control for Anti-Siglec-2/CD22 Antibody (NCI m971) can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Others  
Inflammation or Immune System Disease  
/
HY-D1408 DMTr-4'-Me-U-CED-TBDMS phosphoramidite
DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure.
DNA Stain   Phosphoramidites  
Blood or Cardio-cerebrovascular Disease  
/
HY-P992441 PHST001
PHST001 is a humanized anti-CD24 antibody. PHST001 binds cell-surface CD24, blocks CD24-Siglec10 interaction, and engages Fc receptors to promote macrophage-mediated tumor cell phagocytosis. PHST001 inhibits growth of breast cancer and ovarian cancer, and reduces metastatic lesions in mouse xenograft models. PHST001 can be used for the research of triple negative breast cancer, HER2+ breast cancer, metastatic tumors, and ovarian cancer.

Species: Human

Transmembrane Glycoprotein  
Ovarian Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer  
/
HY-P5487 GluR23Y
GluR23Y is a biological active peptide. (This GluR23Y peptide was used in ELISA cell-surface assay for the insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y prevented any insulin-induced reduction. The blockade of insulin action was observed when the GluR23Y peptide was delivered into neurons by fusing it to the membrane transduction domain of HIV-1.)
iGluR  
/
HY-113205S 15-Keto-prostaglandin E2-d9
15-Keto-prostaglandin E2-d9 is the d9 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
Isotope-Labeled Compounds   Endogenous Metabolite   Prostaglandin Receptor   STAT   PPAR   Fungal   Drug Metabolite  
Blood or Cardio-cerebrovascular Disease   Breast Cancer   Renal Disease   Cryptococcal Infection  
/
HY-158471 Core 1 O-glycan (C1)
Core 1 O-glycan (C1) is an important O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-N3913 Furowanin A
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells.
STAT   Bcl-2 Family  
/
HY-P4129 Rabies Virus Matrix Protein Fragment(RV-MAT)
Rabies Virus Matrix Protein Fragment (RV-MAT) is a polypeptide. Rabies Virus Matrix Protein Fragment targets the acetylcholine receptor (AChR) that exists on the cell surface.
nAChR  
/
HY-D1686 Biotin-16-UTP
Biotin-16-UTP is an active substrate for RNA polymerase. Biotin-16-UTP can replace UTP in the in vitro transcription reaction for RNA labeling.
DNA Stain  
/
HY-P991973 HuL001
HuL001 is a specific monoclonal antibody targeting ENO1. HuL001 remodels the tumor microenvironment by inhibiting cancer-associated fibroblasts, thereby suppressing the progression of multiple myeloma. HuL001 can be used for research on cancers such as colorectal cancer, pancreatic ductal adenocarcinoma, and myeloma.

Species: Human

Enolase  
Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Ductal Adenocarcinoma  
/
HY-B0158S8 Cytidine-d13
Cytidine-d13 (Cytosine β-D-riboside-d13) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
Nucleoside Antimetabolite/Analog   Endogenous Metabolite   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-P990505 Anti-Siglec-15/CD33L3 Antibody
The Anti-Siglec-15/CD33L3 Antibody is a human-derived antibody expressed in CHO cells, targeting Siglec-15/CD33L3. The Anti-Siglec-15/CD33L3 Antibody contains a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 146.02 kDa. The isotype control for the Anti-Siglec-15/CD33L3 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-113138R 3-Methyluridine (Standard)
3-Methyluridine (Standard) is the analytical standard of 3-Methyluridine. This product is intended for research and analytical applications. 3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance.
Endogenous Metabolite   Reference Standards  
Metabolic or Endocrine Disease  
/
HY-152303S N6-(4-Methoxybenzyl)adenosine-d3
N6-(4-Methoxybenzyl)adenosine-d3 is deuterium labeled N6-(4-Methoxybenzyl)adenosine. N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
Isotope-Labeled Compounds   Nucleoside Antimetabolite/Analog  
/
HY-W145682 Blood group H disaccharide
Blood group H carbohydrate is a carbohydrate containing two monosaccharides, fucose and galactose, linked by α1-2 glycosidic bonds. It is the precursor of ABO blood group antigens, which are present on the surface of red blood cells and play a role in immune recognition and transfusion compatibility. Type H disaccharides have diverse applications in biochemical research, especially in the study of carbohydrate-protein interactions and the biosynthesis of blood group antigens. In addition, it can be used as a diagnostic tool to identify ABO blood group phenotypes.
Biochemical Assay Reagents  
/
HY-113205S1 15-Keto-prostaglandin E2-d4
15-Keto-prostaglandin E2-d4 is the d4 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
Isotope-Labeled Compounds   Endogenous Metabolite   Prostaglandin Receptor   STAT   PPAR   Fungal   Drug Metabolite  
Blood or Cardio-cerebrovascular Disease   Breast Cancer   Renal Disease   Cryptococcal Infection  
/
HY-N7068R Mupirocin calcium hydrate (Standard)
Mupirocin (calcium hydrate) (Standard) is the analytical standard of Mupirocin (calcium hydrate). This product is intended for research and analytical applications. Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.
Reference Standards   Bacterial   Antibiotic  
Infection   Inflammation or Immune System Disease  
/
HY-P5407 HD5
HD5 is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer.
SARS-CoV   Angiotensin-converting Enzyme (ACE)  
Colorectal Cancer   Small Cell Lung Cancer   Epithelial Ovarian Cancer   SARS-CoV-2 Infection   HPV Infection  
/
HY-N14769 2-Hydroxyaclacinomycin B
2-Hydroxyaclacinomycin B is an anthracycline antibiotic. 2-Hydroxyaclacinomycin B can be found in Strptomyces galilaeus A-862 (FERM BP-45). 2-Hydroxyaclacinomycin B inhibits RNA synthesis and has anti-tumor activity.

Source: Streptomyces galilaeus

Bacterial  
Cancer  
/
HY-15448S1 Tezacaftor-d6
Tezacaftor-d6 (VX-661-d6) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation.
Isotope-Labeled Compounds   CFTR  
Cancer  
/
HY-D3308 CoelPhos
CoelPhos is the cell-impermeable coelenterazine derivative. CoelPhos specifically recognizes extracellular GLuc and generates luminescent signals. CoelPhos is a practical bioluminescent tool for monitoring exocytic processes such as cell surface membrane fusion.
Biochemical Assay Reagents  
/
HY-P990163 Anti-Mouse Siglec-H Antibody (440c)
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis.

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-W766368 C6 Ceramide-13C2,d2
C6 Ceramide-13C2,d2 (C6-Cer-13C2,d2) is the deuterium labeled and 13C-labeled C6 Ceramide (HY-19542). C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects.
Isotope-Labeled Compounds   Apoptosis  
/
HY-P99109 Zimberelimab
Zimberelimab (GLS-010) is a fully human IgG4 anti-PD-1 monoclonal antibody with an EC50 of 210 pM for human PD-1. Zimberelimab effectively blocks the binding of PD-L1 and PD-L2 to cell-surface PD-1 in CHO-S cells, with IC50 values of 580 pM and 670 pM, respectively. Zimberelimab shows antitumor activities, and can be used for various cancers research, including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma.

Species: Human

PD-1/PD-L1  
Respiratory Disease   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
/
HY-D1669 Biotin-11-UTP
Biotin-11-UTP is a Biotin-labeled uridine triphosphate (UTP), containing 11 atoms in the linker between biotin and UTP. Biotin-11-UTP can biotinylate transcribed RNA in vitro and has been widely used as labeling RNA probe. Biotin-11-UTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Fluorescent Dye  
/
HY-P992488 ZV05
ZV05 (ZV0501 Antibody) is an anti-5T4 monoclonal antibody with an EC50 of 4.3 ng/mL against h5T4. ZV05 does not induce apoptosis or interfere with cell cycle progression. ZV05 accumulates specifically in 5T4-positive tumor xenografts. ZV05 can serve as the antibody component of antibody-active molecule conjugates (ADCs) to bind the 5T4 glycoprotein, thereby enabling targeted delivery of toxins. ZV05 is used in studies of 5T4-positive cancers, including triple-negative breast cancer.

Species: Human

Transmembrane Glycoprotein   ADC Antibodies  
Triple-Negative Breast Cancer  
/
HY-P5407A HD5 TFA
HD5 TFA is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 TFA binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 TFA can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer.
SARS-CoV   Angiotensin-converting Enzyme (ACE)  
Colorectal Cancer   Small Cell Lung Cancer   Epithelial Ovarian Cancer   SARS-CoV-2 Infection   HPV Infection  
/
HY-N10103 Neoschaftoside
Neoschaftoside is a C-glycosyl flavonoid EGFR modulator, antifungal agent, and piercing-sucking stimulant for planthoppers. Neoschaftoside forms stable EGFR complexes, restricts global protein movement, enhances related dynamic processes, and inhibits tumor progression. Neoschaftoside interacts with EGFR core regulatory genes associated with lung cancer. Neoschaftoside inhibits Botrytis cinerea. Neoschaftoside can be used in research related to lung cancer and Botrytis cinerea infections.
Fungal   EGFR  
Lung Cancer   Fungal Infection  
/
HY-158470 Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labelled
Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is a 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 2. Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-158469 Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled
Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is a disialylated, 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-P991708 Olsutamig
Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells.

Species: Human

PSMA   CD3  
Cancer  
/
HY-W751835 Baloxavir-d4
Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity.
Isotope-Labeled Compounds  
Cancer  
/
HY-N8840 Laricitrin
Laricitrin is a natural product with multiple biological activities. Laricitrin inhibits the phosphorylation and DNA-binding activity of STAT3, and downregulates the expression of IL-10. Laricitrin acts as an immunomodulator to regulate the differentiation, maturation and function of dendritic cells (DCs). Laricitrin inhibits the migration and invasion of lung cancer cells, and ameliorates lung cancer progression. Laricitrin can be used in research related to hypertension and lung cancer.
STAT   Interleukin Related  
Lung Cancer   Hypertension  
/
HY-P991611 ART5803
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis.

Species: Human

iGluR  
Inflammation or Immune System Disease  
/
HY-P11023 E16-uPA24
E16-uPA24 is a chimeric peptide targeting urokinase-type plasminogen activator receptor (uPAR). E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research.
Others  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-NP0194C C1q Protein (rat)
C1q Protein (rat) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rat) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (rat) can be used for the research of mutiple disease.
Complement System  
Inflammation or Immune System Disease  
/
HY-P991455 PTX-35
PTX-35 is a costimulatory agonist antibody targeting TNFRSF25 as well as an immune activator that selectively regulates activated CD8+ T cells. PTX-35 enhances the expansion, survival and effector functions of T cells, while reducing the inhibitory activity of regulatory T cells and impairing their stability. PTX-35 exhibits anti-tumor activity, effectively delaying tumor progression and prolonging survival. PTX-35 has a synergistic effect with anti-OX40 agonist antibodies. PTX-35 can be widely used in research on related diseases such as colon cancer and melanoma.

Species: Human

TNF Receptor  
Colorectal Cancer   Cancer Immunology   Immunotherapy for Melanoma  
/
HY-W721874 Adrenosterone-d10
Adrenosterone-d10 ((+)-Adrenosterone-d10) is the deuterium labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.
Isotope-Labeled Compounds   Androgen Receptor   Endogenous Metabolite  
/
HY-179672 7.5M LiCl,RNase-free
7.5M LiCl, RNase-free is an RNase-free lithium chloride solution. 7.5M LiCl, RNase-free efficiently precipitates RNA molecules with a length of at least 100 nucleotides. 7.5M LiCl, RNase-free is used for mRNA purification after in vitro transcription or ribosomal RNA purification.
Biochemical Assay Reagents  
/
HY-135780 3'-Deoxyuridine-5'-triphosphate
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.
Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W011834S 2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d3 is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.
Isotope-Labeled Compounds   HCV  
Infection  
/
HY-126327 UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.
Histone Methyltransferase  
Cancer  
/
HY-145977A m7GpppGmpG ammonium solution (100 mM)
m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
Nucleoside Antimetabolite/Analog  
/
HY-P991358 XOMA-213
XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) targeting the prolactin receptor (PRLR), with a Kd value of 2 nM against the human target. XOMA-213 blocks PRL-induced cell proliferation and inhibits the activation of multiple PRLR ligands, including PRL and human growth hormone (hGH). XOMA-213 suppresses PRL-induced phosphorylation of Stat5, Akt and ERK1/2 in cells. XOMA-213 induces tumor regression, delays disease progression, and inhibits PRLR signaling as well as tumor growth. XOMA-213 can be used in research related to breast cancer.

Species: Human

Estrogen Receptor/ERR   STAT   Akt  
Breast Cancer  
/
HY-P10427A DV1 TFA
DV1 TFA is a CXCR4 inhibitor with anti-proteolytic properties that specifically blocks the binding of SDF-1α to its receptor. DV1 TFA inhibits the migration of breast cancer cells and enables the targeted delivery of avidin-PLGA nanoparticles to CXCR4-expressing cancer cells. DV1 TFA not only effectively suppresses the progression of metastatic breast cancer in mouse models, but also preferentially accumulates in brain tumor tissues rather than normal brain tissues, showing potential for inhibiting intracranial tumor metastasis. As a humoral immune stimulant, DV1 TFA induces the production of specific IgG, neutralizing antibodies and cellular immune responses, thereby providing the host with protection against lethal challenges. DV1 TFA has been applied to studies on CXCR4-expressing cancers, glioblastoma, dengue fever and other related diseases.
CXCR   Dengue Virus  
Infection  
/
HY-P990605 Anti-CD33 Antibody
Anti-CD33 Antibody (IMGN-779 antibody) is a CHO-expressed humanized antibody targeting Siglec-3/CD33. Anti-CD33 Antibody carries a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.6 kDa. The isotype control for Anti-CD33 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Others  
Inflammation or Immune System Disease  
/
HY-P991864 Annexuzlimab
Annexuzlimab is a humanised IgG1 monoclonal antibody which specifically binds to ANXA1 disrupting its interaction with formyl peptide receptors 1 and 2 (FPR1/2). Annexuzlimab arrests cell cycle progression with cancer cells accumulating in the G1 phase. Annexuzlimab targets secreted ANXA1, preventing FPR1/2 activation and reducing cancer progression. Annexuzlimab can be used for the research of triple negative breast cancer, pancreatic cancer and osteosarcoma.

Species: Human

Formyl Peptide Receptor (FPR)  
Pancreatic Cancer   Triple-Negative Breast Cancer  
/
HY-P99928 Efprezimod alfa
Efprezimod alfa (MK 7110; CD24 Fc) is a humanized CD24-Fc fusion protein. Efprezimod alfa enhances the interaction between CD24 and Siglec-10, thereby regulating the response of innate immune cells to damage-associated molecular patterns, inhibiting the activation of antigen-presenting cells and subsequent inflammatory responses. Efprezimod alfa is applicable to the research of acute graft-versus-host disease and acquired immunodeficiency syndrome.
Transmembrane Glycoprotein  
Cancer  
/
HY-NP0190 Ulex Europaeus Agglutinin I (Biotinylated)
Ulex Europaeus Agglutinin I Biotinylated (UEA I Biotinylated) is a biotinylated lectin that binds to α1,2-fucosylated proteins and cell-surface glycoconjugates containing α-L-fucose. Ulex Europaeus Agglutinin I Biotinylated serves as a histochemical marker for endothelial cells.
Fluorescent Dye  
/
HY-145794 ZA3-Ep10
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.
Liposome  
/
HY-101218 N-Biotinyl-6-aminohexanoic acid
N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) can be used to perform biotinylation.
Sialyltransferase  
/
HY-P10530 Nrf2 (69-84)
Nrf2 (69-84) is a peptide fragment of Nrf2 protein that contains the key ETGE motif, which is an important region for binding to the Kelch domain of Keap1 protein. Nrf2 (69-84) can be used to study the role of Nrf2 in the development and progression of diseases, especially in cancer, neurodegenerative diseases and inflammatory diseases.
Keap1-Nrf2  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-15448S Tezacaftor-d4
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface.
CFTR   Autophagy  
Cancer  
/
HY-P991364 Aldastotug
Aldastotug (PYX-106; BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. Aldastotug reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation. Aldastotug induces significantly increased levels of IFNγ and TNFα in T cells. Aldastotug can be used in cancer immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-B1817A Zinc acetate, 99.99% trace metals basis
Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions.
CDK   Heme Oxygenase (HO)   Apoptosis  
/
HY-N3255 Minecoside
Minecoside is a CXCR4/STAT3 inhibitor with anticancer and anti-inflammatory activity. Minecoside decreases CXCR4 expression and suppresses STAT3 activation, thus to inhibit CXCL 12-induced invasion. Minecoside potently inhibits cancer metastasis and promotes apoptotic progression.
CXCR   STAT  
Lung Cancer   Breast Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
/
HY-P991042 Anti-IGFBP2 Antibody (M14)
Anti-IGFBP2 Antibody (M14) is an human anti-IGFBP2 monoclonal inhibitory antibody, which binds IGFBP2 with high affinity and blocks its binding with IGF1. Anti-IGFBP2 Antibody (M14) inhibits human endothelial cell recruitment, thus blocks the tumor progression of human metastatic cancer.

Species: Human

IGF-1R  
Cancer  
/
HY-112535 (R)-Lith-O-Asp
(R)-Lith-O-Asp (α-2,3-Sialyltransferase-IN-1) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM.
Sialyltransferase  
Cancer   Inflammation or Immune System Disease  
/
HY-P991319 TAB-004
TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.

Species: Human

Others  
Pancreatic Cancer   Triple-Negative Breast Cancer  
/
HY-P5959 PTBP1 α3-helix derived peptide P1 TFA
PTBP1α3-helix derived peptide P1 is a polypeptide that inhibits RNA binding.
Others  
/
HY-P991636 AK006
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research.

Species: Human

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-145975A m7Gpppm6AmpG ammonium solution (100 mM)
m7Gpppm6AmpG ammonium solution (100 mM) is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG ammonium can be used for RNA synthesis in vitro.
DNA/RNA Synthesis  
/
HY-D1686B Biotin-16-UTP tetrasodium
Biotin-16-UTP tetrasodium is an active substrate for RNA polymerase. Biotin-16-UTP tetrasodium can replace UTP in the in vitro transcription reaction for RNA labeling.
DNA Stain  
/
HY-P99573 Tebotelimab
Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity.

Species: Human

LAG-3  
Inflammation or Immune System Disease   Triple-Negative Breast Cancer  
/
HY-W041895S1 DL-Glutamic acid-d3
DL-Glutamic acid-d3 is the d3-labeled DL-Glutamic acid (HY-W041895). DL-Glutamic acid is a racemic amino acid mixture and an antibacterial agent. DL-Glutamic acid reduces RNA and DNA levels, with a more significant effect on RNA. DL-Glutamic acid inhibits cell division of Rhodospirillum rubrum.
Isotope-Labeled Compounds   Endogenous Metabolite   DNA/RNA Synthesis   Bacterial  
Bacterial Infection  
/
HY-W091784 3'-O-Methylguanosine
3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.
Endogenous Metabolite   Orthopoxvirus   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
Lung Cancer   Leukemia/Lymphoma/Myeloma   Orthopoxvirus Infection  
/
HY-P99230 Pinatuzumab
Pinatuzumab is a humanized monoclonal antibody targeting cell-surface antigen CD22. Pinatuzumab can be used to synthesize antibody-drug conjugate (ADC) such as Pinatuzumab vedotin (HY-141602). Pinatuzumab can be studied in research on cancer such as non-Hodgkin lymphoma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Integrin   CD22  
Cancer  
/
HY-B0158S7 Cytidine-13C9
Cytidine-13C9 (Cytosine β-D-riboside-13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
Nucleoside Antimetabolite/Analog   Endogenous Metabolite   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-P1745 InsB (9-23)
InsB (9-23) (Insulin B chain (9-23)) is an HLA-DQ8-restricted insulin B-chain peptide composed of amino acid residues 9-23. InsB (9-23) serves as a major MHC II class-restricted antigen. InsB (9-23) supports the recognition and activation of T cells, stimulates the secretion of IFN-γ and cytokines, and induces cross-reactive immune responses. InsB (9-23)-specific CD4 T cells can initiate diabetes. InsB (9-23) can be used in research related to type 1 diabetes and autoimmune diabetes.
MHC   Insulin Receptor   IFNAR  
Inflammation or Immune System Disease  
/
HY-I0960S9 Uracil-d4
Uracil-d4 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
Endogenous Metabolite  
Cancer  
/
HY-P991480 ONC-841
ONC-841 is a blood-brain barrier-permeable, humanized monoclonal antibody targeting SIGLEC10. As an immune checkpoint inhibitor, ONC-841 restores the functions of immune effector cells such as T cells and enhances anti-tumor immune responses by blocking inhibitory signals mediated by SIGLEC10. ONC-841 restores the phagocytic and migratory activities of microglia, and promotes the phagocytosis of Amyloid-β and Tau protein aggregates by microglia. ONC-841 is applicable to research related to solid tumors and Alzheimer's disease.

Species: Human

Transmembrane Glycoprotein   Tau Protein   Amyloid-β  
Cancer   Alzheimer's Disease  
/
HY-N1033 12-Hydroxyjasmonic acid
12-Hydroxyjasmonic acid is a metabolite of Jasmonic acid (HY-122464A) and an inducer of defense responses. 12-Hydroxyjasmonic acid can be isolated from potato leaflets. During the response of sugar beet plants to Cercospora beticola infection, 12-Hydroxyjasmonic acid is released through deglycosylation of its glucoside form and participates in the Jasmonic acid-mediated defense signaling pathway. 12-Hydroxyjasmonic acid mediates changes in source-sink relationships during pathogen infection, prioritizing the activation of defense processes over growth processes. 12-Hydroxyjasmonic acid serves as a substrate for salicylic acid Glycosyltransferases in tobacco and rice. 12-Hydroxyjasmonic acid can induce leaflet closure in Samanea saman. 12-Hydroxyjasmonic acid acts as a potato tuber-inducing substance. 12-Hydroxyjasmonic acid does not induce protoplast shrinkage in extensor motor cells of Samanea saman. 12-Hydroxyjasmonic acid can be used in studies related to brown spot disease.
Phytohormone   Drug Metabolite   Glycosyltransferase  
Plant Infection  
/
HY-153108 3'-O-Me-m7G(5')ppp(5')A solution (100 mM)
3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100 mM), anti-reverse cap analog, has a special RNA cap structure. 3'-O-Me-m7G(5')ppp(5')A solution (100 mM) improves mRNA translation efficiency and stability, reduces translational inhibition by proteins such as IFIT1, and enables stronger and longer-lasting expression of the target protein. The RNA cap structure is a common feature of mRNAs in some RNA viruses and eukaryotes, and it serves as a signal for translation initiation.
DNA/RNA Synthesis  
/
HY-125961 T3Inh-1
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream).
FGFR   Glycosyltransferase  
Breast Cancer  
/
HY-P99231 Edrecolomab
Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research.

Species: Human

Others  
Cancer  
/
HY-W250124 Ribonucleic acid (yeast)
Ribonucleic acid (RNA) (yeast) is a ribonucleic acid isolated from yeast, characterized as a polynucleotide containing primary and secondary phosphate groups, amino groups, and purine-pyrimidine hydroxyl groups per 4 corrected phosphorus atoms. Ribonucleic acid (yeast) is widely used in scientific research as a substrate for nuclease detection, a carrier in ethanol precipitation processes, and a standard control for molecular biology techniques.
DNA/RNA Synthesis  
/
HY-173496 ST6GAL1-IN-1
ST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor (IC50 = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin/VEGFR2-mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC).
Sialyltransferase   Integrin   VEGFR   Akt  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis  
/
HY-E70055 α-2,6-Sialyltransferase, Pasteurella multocida (P-1059)
alpha-2,6-Sialyltransferase (Pd26ST) (EC 2.4.99.1) is capable of sialylating both terminal and internal galactose and N-acetylgalactosamine, which producing terminal α2,6-sialosides.

Species: Pasteurella multocida (P-1059)

Sialyltransferase  
/
HY-E70056 α2,3-Sialyltransferase, Pasteurella multocida (P-1059)
α2,3-Sialyltransferase, Pasteurella multocida (P-1059) (PmST1(M144D)), a sialyltransferase, can be isolated from Pasteurella multocida. alpha-2,3-Sialyltransferase (PmST1) can be converted into regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening.
Sialyltransferase  
Infection  
/
HY-P10396 Elf18
Elf18 is a peptide fragment of bacterial translation elongation factor Tu (EF-Tu). Elf18 can be recognized by plant pattern recognition receptors, thereby inducing an immune response. Elf18 can enhance plants' resistance to pathogens and can be used in research related to plant immune responses.
Bacterial  
Infection   Inflammation or Immune System Disease  
/
HY-17462 Adrenosterone
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.
Androgen Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease   Breast Cancer   Thyroid Cancer  
/
HY-P991728 Zarutatug
Zarutatug (TORL-3-600 antibody) is an IgG1κ humanized antibody targeting cadherin 17 (CDH17). It selectively binds to cell-surface CDH17, triggering endocytosis and trafficking to lysosomes. Zarutatug can be used to construct ADCs, such as TORL-3-600.

Species: Human

Cadherin   ADC Antibodies  
Cancer  
/
HY-NP0194A C1q Protein (mouse)
C1q Protein (mouse) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (mouse) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (mouse) can be used for the research of mutiple disease.
Complement System  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P99371 Lirentelimab
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.

Species: Human

Apoptosis  
Inflammation or Immune System Disease  
/
HY-E70024 CMP-sialic acid synthetase (NmCSS)
CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases.
Sialyltransferase  
Metabolic or Endocrine Disease  
/
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA
PTBP1-RNA-binding inhibitor (PTBP1 α3-helix derived peptide) P6 TFA is a cell-permeable PTBP1 inhibitor. PTBP1-RNA-binding inhibitor P6 TFA binds to the α3 helix binding site of the PTBP1 RRM1 domain, and disrupts the synergistic RNA-binding effect of the RRM1 and RRM2 domains of PTBP1. PTBP1-RNA-binding inhibitor P6 (TFA) regulates the regulatory pattern of PTBP1-related alternative splicing events, and thus exhibits anticancer potential.
DNA/RNA Synthesis  
Cancer  
/
HY-E70285 beta-1,4-Galactosyltransferase 1 (Y285L)
beta-1,4-Galactosyltransferase 1 (Y285L) can enzymatic synthesis of the LacdiNAc motif. beta-1,4-Galactosyltransferase 1 (Y285L) can transfer of GalNAc from UDP-GalNAc.

Species: Human

Glycosyltransferase  
Metabolic or Endocrine Disease  
/
HY-P10091 CD24/Siglec-10 blocking peptide, CSBP
CD24/Siglec-10 blocking peptide, CSBP can not only block the interaction of CD24/Siglec-10 but also PD-1/PD-L1. CD24/Siglec-10 blocking peptide, CSBP can induce the phagocytosis of tumor cell.
PD-1/PD-L1  
Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-P99829 Cofetuzumab pelidotin
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research.
Antibody-Drug Conjugates (ADCs)   Microtubule/Tubulin  
/
HY-145974A m7GpppAmpG ammonium solution (100 mM)
m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research.
DNA/RNA Synthesis   Eukaryotic Initiation Factor (eIF)  
/
HY-P9965 Elotuzumab
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-P990792 Anti-Mouse CD4 Antibody (GK1.5)
Anti-Mouse CD4 Antibody (GK1.5) is an anti-mouse CD4 IgG2b monoclonal antibody. Anti-Mouse CD4 Antibody (GK1.5) can significantly deplete CD4+ T cells. Anti-Mouse CD4 Antibody (GK1.5) can extend the survival rate of xenograft models. Anti-Mouse CD4 Antibody (GK1.5) can be used for research on immunology. The recommend isotype control of Anti-Mouse CD4 Antibody (GK1.5): Rat IgG2b kappa, Isotype Control (HY-P990682).

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease   Melanoma  
/
HY-E70097 Sialidase (α2-3-6-8-9)
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling.
Sialyltransferase  
/
HY-P99054 Tusamitamab
Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542).

Species: Human

Transmembrane Glycoprotein   ADC Antibodies  
Gastric Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer  
/
HY-P99971 Gemtuzumab
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Species: Human

ADC Antibodies   Transmembrane Glycoprotein  
Cancer  
/
HY-P990673 Vandortuzumab
Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC).

Species: Human

ADC Antibodies   Transmembrane Glycoprotein   Mitosis  
Castration-Resistant Prostate Cancer  
/
HY-E70289 Bovin beta-1,4-galactosyltransferase 1 (Y289L)
Bovin beta-1,4-galactosyltransferase 1 (Y289L) (Bovin B4GALT1 (Y289L)) is a mutated form of bovine-derived galactosyltransferase with a mutation at the Y289L genetic site. Bovin beta-1,4-galactosyltransferase 1 can label O-GlcNAcylated proteins with an N-azidoacetylgalactosamine (GalNAz) group. This labeling method allows for the specific, unbiased, and global labeling of O-GlcNAcylated proteins. After labeling, the appended azide group can react with a wide variety of alkyne-modified chemical probes, facilitating multiple downstream analyses.

Species: Bovin

Glycosyltransferase  
Cancer  
/
HY-P70384 GFRA1/GDNFR-alpha-1 Protein, Human (HEK293, His)
The GFRA1/GDNFR-alpha-1 Protein serves as a receptor for GDNF, facilitating GDNF-induced autophosphorylation and activation of the RET receptor. In a complex, two molecules of GDNFR-alpha-1 are believed to associate with the disulfide-linked GDNF dimer and two molecules of RET. It interacts with RET and SORL1, either alone or in a complex with GDNF, leading to GFRA1 internalization without degradation. GFRA1/GDNFR-alpha-1 Protein, Human (HEK293, His) is the recombinant human-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TGF-beta Superfamily Neurotrophic Factors Cytokine Receptors GDNF family GFR-alpha-1

/
HY-P75377 CD83 Protein, Human (HEK293, His)
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Human (HEK293, His) is the recombinant human-derived CD83 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P74260 CD83 Protein, Mouse (HEK293, His)
CD83 protein may be a key player in antigen presentation and cellular interactions during lymphocyte activation, highlighting its importance in immune processes. It potentially orchestrates antigen presentation and acts as a monomer. Investigating CD83's mechanisms in antigen presentation and lymphocyte activation could provide insights into its crucial role in shaping immune responses and cellular interactions within the immune system. CD83 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD83 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P76360 GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His)
GFRA1/GDNFR-alpha-1, a receptor for GDNF, mediates GDNF-induced autophosphorylation and activation of the RET receptor. It interacts with RET and forms a complex with disulfide-linked GDNF dimer, and interacts with SORL1. The SORL1-GFRA1 interaction results in GFRA1 internalization without degradation. GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA1/GDNFR-alpha-1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Receptor Proteins TGF-beta Superfamily Neurotrophic Factors Cytokine Receptors GDNF family GFR-alpha-1

/
HY-P72703 CD83 Protein, Human (HEK293, Fc)
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Human (HEK293, Fc) is the recombinant human-derived CD83 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P72704 CD83 Protein, Mouse (HEK293, Fc)
CD83 protein may be a key player in antigen presentation and cellular interactions during lymphocyte activation, highlighting its importance in immune processes. It potentially orchestrates antigen presentation and acts as a monomer. Investigating CD83's mechanisms in antigen presentation and lymphocyte activation could provide insights into its crucial role in shaping immune responses and cellular interactions within the immune system. CD83 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD83 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Mouse; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P75375 CD83 Protein, Rat (HEK293, His)
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Rat (HEK293, His) is the recombinant rat-derived CD83 protein, expressed by HEK293 , with C-His labeled tag.

Species: Rat; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P75921 MAP3K8/TPL-2 Protein, Human (sf9, GST)
MAP3K8/TPL-2 is critical for LPS-induced, TLR4-mediated activation of MAPK/ERK, leading to TNF production by macrophages. It regulates T cell differentiation, IFNG expression, and host resistance to bacterial infections by negatively regulating type I interferon production. MAP3K8/TPL-2 Protein, Human (sf9, GST) is the recombinant human-derived MAP3K8/TPL-2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins STE STE-Unique MAP3K8/COT

/
HY-P76245 CD83 Protein, Cynomolgus (HEK293, Fc)
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD83 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Cynomolgus; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P75376 CD83 Protein, Rat (HEK293, Fc)
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD83 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Rat; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P76246 CD83 Protein, Cynomolgus (HEK293, His)
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD83 protein, expressed by HEK293 , with C-His labeled tag.

Species: Cynomolgus; Source: HEK293

CD Antigens T Cell CD Proteins B Cell CD Proteins Dendritic Cell CD Proteins CD83

/
HY-P80055 CD4 Antibody (YA537)
CD4 Antibody (YA537) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD4.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P86568 CD3 epsilon Antibody (YA6260)
CD3 epsilon Antibody (YA6260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD3 epsilon.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P80883 RNA Polymerase II Subunit B1 Antibody (YA090)
RNA Polymerase II Subunit B1 Antibody (YA090) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RNA Polymerase II Subunit B1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P82521 GPA33 Antibody (YA2266)
GPA33 Antibody (YA2266) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPA33.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P84994 CD4 Antibody (YA4686)
CD4 Antibody (YA4686) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P87816 CD4 Antibody (YA7501)
CD4 Antibody (YA7501) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to CD4.

Host: Rabbit; Reactivity: Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P87784 CD4 Antibody (YA7469)
CD4 Antibody (YA7469) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to CD4.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P811002 CD200R Antibody
CD200R Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CD200R.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

/
HY-P85013 CD96 Antibody (YA4705)
CD96 Antibody (YA4705) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD96.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Nanobodies Primary Antibodies

/
HY-P86910 Human CD200R1 Antibody (YA6603)
Human CD200R1 Antibody (YA6603) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Human CD200R1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-K0358 Human CD66b+ Cell Positive Selection Kit

MCE Human CD66b+ Cell Positive Selection Kit is designed for the efficient isolation of CD66b+ cells from human peripheral blood single-cell suspensions. CD66b+ cells are first specifically labeled with the CD66b Capture Antibody and subsequently captured using Releasable Magnetic Beads. Following magnetic separation, the beads are detached from the cell surface using Magnetic Beads Release Buffer, resulting in highly purified CD66b+ cells free of residual magnetic bead labeling.

Cell Biology Cell Isolation

/
HY-K2018 OptiLNP RNA Transfection Reagent

MCE OptiLNP RNA Transfection Reagent is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into common cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2019 OptiLNP RNA Transfection Reagent (Stem Cells)

MCE OptiLNP RNA Transfection Reagent (Stem Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into stem cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2020 OptiLNP RNA Transfection Reagent (Primary Immune Cells)

MCE OptiLNP RNA Transfection Reagent (Primary Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into primary immune cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2021 OptiLNP RNA Transfection Reagent (Immune Cells)

MCE OptiLNP RNA Transfection Reagent (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into immune cells.

Cell Biology Cell Culture Cell Transfection

/
HY-K2022 In vivo OptiLNP RNA Transfection Reagent (Systemic Effect)

MCE In vivo OptiLNP RNA Transfection Reagent (Systemic Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions systemically.

Cell Biology Cell Culture Cell Transfection

/
HY-K2026 OptiLNP Short-Chain RNA Transfection Reagent

MCE OptiLNP Short-Chain RNA Transfection Reagent is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of short-chain RNA into common cells.

Cell Biology Cell Culture Cell Transfection

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Keywords

glycoRNA | cell-surface RNA | RNA glycosylation | Siglecs | immune recognition | cancer progression