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Regulatory Circuits for Hyperalgesia

Chronic Inflammation Intercellular Communication & Diseases Calcium Homeostasis Cellular Stress

Regulatory circuits determine whether nociceptive input remains proportionate to tissue threat or becomes amplified beyond the initiating injury and its protective purpose. Hyperalgesia is an increased pain response to a stimulus that is normally painful, whereas allodynia is pain evoked by a normally innocuous stimulus. Both can arise when injury or inflammation changes gain across peripheral nociceptors, spinal dorsal-horn networks, ascending pathways, and descending brainstem control. This circuit view developed beyond a linear pain pathway because nociceptive signals are filtered by local excitation and inhibition, behavioral state, stress, expectation, and prior activity. Plasticity can protect injured tissue transiently, but persistent facilitation can convert an adaptive response into chronic pain[1][2][3][4].

Peripheral transducers first encode thermal, mechanical, and chemical danger and become sensitized by inflammatory mediators. Repeated nociceptor input can then induce central sensitization—a prolonged but reversible increase in excitability and synaptic efficacy within central nociceptive pathways. Clinically, this can manifest as secondary hyperalgesia, enhanced temporal summation, aftersensations, and dynamic tactile allodynia. The spinal dorsal horn is the first central synapse and integrates primary afferents, excitatory projection neurons, inhibitory interneurons, and descending inputs. Circuit identity matters because genetically and molecularly defined dorsal-horn populations route mechanical, thermal, itch, and injury-related signals differently rather than relaying a uniform pain code[1][2][3].

Descending control makes regulation bidirectional. The periaqueductal gray-rostral ventromedial medulla system, dorsal reticular nucleus, and ventrolateral medulla can inhibit or facilitate spinal processing according to behavioral priorities. Within the rostral ventromedial medulla, ON- and OFF-cell populations contribute to pain-facilitating and pain-inhibiting output. Dynamic imbalance can amplify pathological pain even after peripheral input falls. Applications include neuropathic pain, osteoarthritis, fibromyalgia, headache, postsurgical pain, visceral hypersensitivity, and inflammatory pain. Drug discovery targets peripheral ion channels, glutamatergic transmission, neuropeptide receptors, inhibitory signaling, glial mediators, and monoaminergic descending pathways, while neuromodulation and behavioral interventions test circuit-level control[1][3][4].

The major gap is identifying which circuit maintains hypersensitivity in an individual. Similar pain ratings can arise from ongoing peripheral input, spinal disinhibition, descending facilitation, impaired inhibition, or combinations, and a blood or imaging marker rarely isolates one mechanism. Future studies should integrate quantitative sensory testing, electrophysiology, spinal and brain imaging, autonomic measures, molecular biomarkers, and longitudinal response to selective perturbation. Preclinical work needs cell-specific recording and manipulation during spontaneous and evoked behavior, with both sexes, ages, and injury stages represented. Translation must avoid suppressing protective pain, motor function, arousal, or cardiovascular regulation. Closed-loop stimulation could target pathological activity only when detected, but algorithms require prospective validation and interpretable physiological signals. Trials should phenotype patients mechanistically and demonstrate that the intervention normalizes a predicted circuit measure alongside pain and function. Researchers also need to distinguish initiation from maintenance: a pathway necessary immediately after injury may become dispensable after central plasticity is established. Durable treatment may require sequentially reducing peripheral drive, restoring spinal inhibition, and recalibrating descending control. The objective is not global analgesia but restoration of appropriate gain, allowing harmful stimuli to remain detectable without persistent amplification[1][2][3][4].

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Cat. No. Product Name Information Application Publication
HY-D0814 DAPI dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
DNA Stain   Sodium Channel  
Neurological, Eye or Ear Disease  
169
HY-D2868 DAPI
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
DNA Stain   Sodium Channel  
Chronic Pain  
153
HY-D1738 DAPI dilactate
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
Fluorescent Dye  
129
HY-10448 Capsaicin
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.
Environmental Pollutants   Endogenous Metabolite   Autophagy   TRP Channel   Apoptosis  
Digestive System Disease   Breast Cancer   Prostate Cancer   Viral Infection   Pain   Digestive System Inflammation   SARS-CoV-2 Infection  
86
HY-L0095V OTAVAchemicals Screening Collection
OTAVAchemicals Screening Collection contains about 270,000 re-supply compounds for prompt delivery. All compounds have undergone quality control to confirm their chemical structures.
83
HY-L0114V Pharmeks Screening Compound Library
This library contains about 439,804 natural and synthetic screening compounds. The information in the database includes logP, H-bond donors, H-bond acceptors, rotable bonds.
83
HY-L0129V MCE Virtual Screening Compound Library1
A collection of over 2 million screening compounds from manufacturers such as VitasM, Specs, Otava and more, available at competitive prices, suitable for virtual screening and AI-driven screening applications.
83
HY-L105 Peptide Library
Peptides are a group of biologically active substances that are involved in various cellular functions of organisms. Peptides are often used in functional analysis, vaccine research and especially in the field of drug research and development. At present, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. MedChemExpress (MCE) offers a comprehensive collection of 2,621 peptides, including bioactive peptides, amino acid derivatives, and blocking peptides. MCE Peptide Library can be used for peptide library screening, peptide drug discovery, vaccine development, target verification, structural activity research, etc.

Structure Classified Libraries

83
HY-L117 Calcium Channel Blocker Library
Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat. MCE supplies a unique collection of 226 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Signaling Pathway Targeting Libraries

83
HY-L118 Sodium Channel Blocker Library
Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion. MCE offers a unique collection of 197 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Signaling Pathway Targeting Libraries

83
HY-L139 Pain-Related Compound Library
Pain is a kind of distressing feeling caused by the stimulation of tissue damage. According to the International Association for the Study of Pain (IASP), pain is defined as ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Pain is usually classified according to its location, duration, underlying causes, and intensity. For example, acute and chronic pain, muscle pain, and nerve pain. Pain is the main symptom of most diseases, which seriously affects the quality of life and body function of patients. In the medical treatment of pain, anti-inflammatory drugs and opioid analgesic agents have traditionally been used, but the side effects are serious. In recent years, targeted drugs targeting the ERK/MAPK pathway or other targets have gradually become a research hotspot. MCE supplies a unique collection of 3,490 compounds targeting key proteins in the pain system. MCE Pain-Related Compound Library is a useful tool for pain related research and anti-pain drug development.

Disease Focused Libraries

83
HY-LD002 DEL B Kit Regular Library
The discovery of hit molecule is a cornerstone of drug development. Among the diverse tools available, DNA-encoded libraries have emerged a revolutionary platform for high-throughput screening. Compared with traditional HTS, DEL features shorter screening processes, lower costs, simpler assays, and larger library capacities. DEL Construction utilizes split-and-pool synthesis, a combinatorial chemistry approach that involves iterative splitting, reaction, and pooling. This strategy enables rapid, exponential assembly of fragments in minimal steps without the need for individual compound synthesis andassoicicated isolation or purification steps, thus greatly reducing overall costs. The technology enables simultaneous affinity screeningof massive compound collections to target proteins in a single step. By coupling chemical structures with unique DNA barcodes, each compound is tagged with a distinct DNA sequence for convenient tracking and decoding.DELs readily enable the construction and efficient screening of libraries containing millions to billions of compounds. As a result, DEL screening combines the dual advantages of high efficiency and low cost, making DEL a transformative technology in modern drug discovery. The DEL kit consists of 50 independent libraries with a total scale of 100 billion compounds. It is constructed through stepwise combinatorial chemistry strategies involving 2-, 3-, and 4-round synthesis. By employing diverse scaffolds and flexible linking strategies, it encompasses various ring systems, linear frameworks, and heterocyclic structures. Screening can be achieved solely through affinity, independent of target-specific activity detection methods. This library is suitable for DEL screening against a wide range of targets.

DNA Encoded Libraries

83
HY-LD004 DEL Covalent Library
DEL technology enables the simultaneous screening of millions or billions of compounds in a single tube by covalently linking each small molecule with a unique DNA sequence. Traditional DEL screening primarily focuses on identifying non-covalent binding molecules, where interactions with the target are reversible. In contrast, DNA‑encoded covalent library is an ultra‑high‑throughput screening library developed on the basis of conventional DNA‑encoded library technology. It incorporates controllable electrophilic covalent warheads capable of forming irreversible covalent bonds with amino acid residues at the active sites of target proteins, including Cys, Lys, Ser, Tyr, and others. This covalent binding enhances binding affinity, prolongs residence time at the target site, and has the potential to overcome challenges associated with traditional non-covalent inhibitors, such as drug resistance or off-target effects. Each compound in the library contains both a binding domain and an electrophilic warhead. It first recognizes and binds to the target through non covalent interactions, and then forms a stable covalent bond with key amino acid residues to achieve irreversible inhibition. This library is specifically designed for the discovery of potent, long lasting, and highly selective covalent inhibitors, particularly for undruggable targets such as kinases, GPCRs, proteases, and mutant oncoproteins. Each molecule is uniquely labeled with a DNA barcode for molecular identification and sequencing decoding. This library is an advanced and highly diverse collection, consists of 35 independent sub-libraries with a total scaleof 14 million compounds, It incorporates over 14 experimentally validated covalent warheads capable of targeting cysteine, lysine, arginine, aspartic acid and glutamic acid. This library is constructed with diverse drug like core scaffolds and integrated controllable covalent warheads, it features structural diversity, reaction spec

DNA Encoded Libraries

83
HY-LD005 DEL D Kit Cyclic Peptide Library
Cyclic peptide library have advantages such as high affinity, high selectivity, and suitability for targeting protein–protein interactions. Through DEL synthesis technology, the library size can achieve hundreds of millions. DEL cyclic peptide library have advantages like low cost andhigh screeing efficiency, making them valuable for discovering lead compounds against challenging drug targets. This cyclic peptide library is constructed with unnatural amino acids as building block, synthesized through DNA-compatible chemical reactions. Each cyclic peptide consist of six amino acids and constrained conformations such as side-chain cross-linking, disulfide bonds, and macrocyclization. These cyclic peptides exhibit significantly improved stability and druggability compared with linear peptides, filling the gap between small molecules and macromolecular biologics. Each cyclic peptide is uniquely conjugated to a DNA barcode sequence for molecular identification and sequencing decoding. MCE’s cyclic peptide library has8 independent sub-libraries, with a total molecular diversity of 1.2 billion. It is constructed via multi-round combinatorial assembly of building blocks and diverse cyclization strategies, facilitating the discovery of cyclic peptide leads for undruggable targets.

DNA Encoded Libraries

83
HY-B0285A Amiloride hydrochloride
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
Sodium Channel   TRP Channel   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Pain   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection  
70
HY-B0285 Amiloride
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
Sodium Channel   TRP Channel   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Pain   Digestive System Inflammation   Cardiovascular Disease  
70
HY-B1618 Corticosterone
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Glucocorticoid Receptor   Endogenous Metabolite   iGluR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   SARS-CoV-2 Infection   Osteoarthritis  
69
HY-15084B Dizocilpine
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
49
HY-15084 Dizocilpine maleate
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
49
HY-N0219 Bicuculline
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice.
GABA Receptor  
Alzheimer's Disease   Parkinson's Disease  
41
HY-100714A D-AP5
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
36
HY-P0201 Substance P
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
Neurokinin Receptor   Endogenous Metabolite  
Infection   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Pancreatic Cancer  
33
HY-B1102 Evans Blue
Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability.
EAAT   iGluR  
Neurodegenerative Disease   Cardiovascular Disease  
32
HY-17551 NMDA
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
iGluR   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
31
HY-107994 Aminooxyacetic acid hemihydrochloride
Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
GABA Receptor  
Cancer   Alzheimer's Disease   Parkinson's Disease  
25
HY-B0649 Propofol
Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic.

Source: Periplaneta americana

Endogenous Metabolite   GABA Receptor  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Depression   Non-Small Cell Lung Cancer   Alzheimer's Disease   Parkinson's Disease  
24
HY-B0185 Lidocaine
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.
Sodium Channel   MEK   ERK   NF-κB   Apoptosis  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection   Obesity   Rheumatoid Arthritis  
23
HY-N1584 Halofuginone
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
DNA/RNA Synthesis   TGF-beta/Smad   Parasite   Sodium Channel   Calcium Channel  
Inflammation or Immune System Disease   Ovarian Cancer   Parasitic Infection   Pulmonary Hypertension  
22
HY-P99001 Human IgG1 kappa, Isotype Control
Human IgG1 kappa, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1 kappa antibody.
Others  
Cancer   Inflammation or Immune System Disease  
20
HY-N0662 Amentoflavone
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase.
Reactive Oxygen Species (ROS)   Apoptosis   Bacterial   Fungal   RSV   GABA Receptor  
Cancer   Digestive System Disease   Viral Infection   Bacterial Infection   Fungal Infection   Digestive System Inflammation   Glucose Metabolism   Alzheimer's Disease   Parkinson's Disease  
19
HY-B0246 Carbamazepine
Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain.
Sodium Channel   Autophagy   Mitophagy   Potassium Channel   Calcium Channel   HDAC  
Breast Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension  
18
HY-N0637 Eriodictyol
Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases.
Melanocortin Receptor   TRP Channel  
Cancer   Inflammation or Immune System Disease   Viral Infection   Obesity   Lung Fibrosis  
16
HY-B0211 Riluzole
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
Sodium Channel   GABA Receptor  
Cancer   Alzheimer's Disease   Parkinson's Disease  
16
HY-14608 L-Glutamic acid
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
Environmental Pollutants   Ferroptosis   iGluR   Endogenous Metabolite   Apoptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
16
HY-103533 Gabazine
Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor.
GABA Receptor  
Alzheimer's Disease   Parkinson's Disease  
15
HY-Y0966 Glycine
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.
Endogenous Metabolite   Ninjurin   VEGFR   iGluR   PROTAC Linkers   Ligands for E3 Ligase  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Schizophrenia   Pain   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Multiple Myeloma   HSV Infection   SARS-CoV-2 Infection   Alzheimer's Disease   Lung Fibrosis  
15
HY-B0007 Baclofen
Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist with blood-brain barrier permeability. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
GABA Receptor  
Depression   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease  
13
HY-10052 Aprepitant
Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.
Neurokinin Receptor   Bacterial   HIV   Antibiotic  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Pancreatic Cancer   Viral Infection   Bacterial Infection   SARS-CoV-2 Infection  
13
HY-106224A Orexin A (human, rat, mouse) TFA
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Orexin Receptor (OX Receptor)  
Neurological, Eye or Ear Disease  
12
HY-106224 Orexin A (human, rat, mouse)
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Orexin Receptor (OX Receptor)  
Neurological, Eye or Ear Disease  
12
HY-18732A L-NMMA acetate
L-NMMA (Tilarginine) acetate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA acetate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA acetate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA acetate is applicable to research related to nociception, bone cancer pain, and myopia.
NO Synthase  
Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Obesity   Lung Fibrosis  
11
HY-100806 Kynurenic acid
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
iGluR   Endogenous Metabolite   Apoptosis   CXCR   GPR35  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Depression   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease  
11
HY-P99003 Human IgG4 (S228P) kappa, Isotype Control
Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.
Others  
Infection   Inflammation or Immune System Disease  
11
HY-B0135 Furosemide
Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
NKCC   GABA Receptor  
Cancer   Metabolic or Endocrine Disease   Cardiovascular Disease   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease  
10
HY-P80757 Mouse IgG Isotype Control
Mouse IgG Isotype Control is a non-conjugated and Mouse origined polyclonal antibody, It can be used as an Mouse IgG isotype control.

Host: Mouse; Reactivity: Species independent

Polyclonal Antibodies Flow Cytometry Antibodies Isotype Control Antibodies Primary Antibodies

10
HY-N0603 20(S)-Ginsenoside Rg3
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
Sodium Channel   Potassium Channel   NF-κB   COX   Amyloid-β   Endogenous Metabolite  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   SARS-CoV-2 Infection   Alzheimer's Disease   Obesity   Rheumatoid Arthritis  
9
HY-N0215 L-Phenylalanine
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

Source: Escherichia coli

Calcium Channel   iGluR   Endogenous Metabolite   Ligands for E3 Ligase  
Metabolic or Endocrine Disease   Breast Cancer   Depression   Pain   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Hypertension  
9
HY-N2165 Vicenin 2
Vicenin 2, a flavonoid, is an orally active angiotensin-converting enzyme (ACE) inhibitor (IC50 of 43.83 μM). Vicenin 2 has radioprotective, anti-nociceptive effects, anti-glycation anti-inflammatory, antioxidant, anticancer, antiangiogenic properties.
Angiotensin-converting Enzyme (ACE)  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Hypertension  
8
HY-P99977 Mouse IgG1 kappa, Isotype Control
Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results.
Others  
Inflammation or Immune System Disease  
8
HY-N0746 Oxysophocarpine
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems. Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC).
Others  
Cancer   Neurological, Eye or Ear Disease  
6
HY-148800 Suzetrigine
Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy.
Sodium Channel  
Neurological, Eye or Ear Disease  
6
HY-19632 Fezolinetant
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Neurokinin Receptor  
Metabolic or Endocrine Disease  
5
HY-P990679 Rat IgG2a kappa, Isotype Control
Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology. Rat IgG2a kappa, an isotype control, can be used as an isotype control for Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144), Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (HY-P990801), and Anti-Mouse IL-2 Antibody (S4B6-1) (HY-P990796).
Others  
Cancer   Inflammation or Immune System Disease  
5
HY-N0067 γ-Aminobutyric acid
γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system.

Source: mammalian central nervous system

Environmental Pollutants   GABA Receptor   Endogenous Metabolite   PROTAC Linkers  
Depression   Alzheimer's Disease   Parkinson's Disease   Type 2 Diabetes  
5
HY-N2258 Poncirin
Poncirin is isolated from Poncirus trifoliata with anti-inflammory activites. Poncirin significantly reduces mechanical hyperalgesia and allodynia in Complete Freund’s Adjuvant (CFA)-induced inflammatory pain models.
Apoptosis  
Digestive System Disease   Digestive System Inflammation  
4
HY-16346 Netupitant
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect.
Neurokinin Receptor  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
4
HY-P1410C D-GsMTx4 TFA
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis.
Piezo Channel   Calcium Channel   mTOR   PI3K   Akt  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-14407A Fosaprepitant dimeglumine
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
4
HY-P1410B D-GsMTx4
D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 inhibits [Ca2+]i elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis.
Piezo Channel   Calcium Channel   mTOR   PI3K   Akt  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-N6691 Veratridine
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow.
Sodium Channel  
Neurological, Eye or Ear Disease  
4
HY-P80879 Rabbit IgG Isotype Control
Rabbit IgG Antibody is a non-conjugated and Rabbit origined polyclonal antibody.It can be used as an isotype control.

Host: Rabbit; Reactivity: Species independent

Flow Cytometry Antibodies Isotype Control Antibodies Primary Antibodies

4
HY-B2114 Escin
Escin, a natural compound of triterpenoid saponins that can be isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
Apoptosis  
Cancer   Digestive System Disease   Viral Infection   Coronavirus Infection   Digestive System Inflammation   Glucose Metabolism  
3
HY-10448R Capsaicin (Standard)
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.
Reference Standards   TRP Channel   Autophagy   Apoptosis   Endogenous Metabolite  
Breast Cancer  
3
HY-P0197 Neurokinin A
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
3
HY-P0187 Senktide
Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50=0.5-3 nM). Senktide less potently agonizes the NK1 receptor (EC50=35 µM). Senktide is promising for research of neurological disease.
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
3
HY-P0062 Ziconotide
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.
Calcium Channel  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
2
HY-N1478 Gardenoside
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study.
P2X Receptor   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
2
HY-P0062B Ziconotide acetate
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research.
Calcium Channel  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
2
HY-P99992 Human IgG1 lambda1, Isotype Control
Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer.
Others  
Inflammation or Immune System Disease   Pancreatic Cancer   Glucose Metabolism  
2
HY-P99978 Mouse IgG2a kappa, Isotype Control
Mouse IgG2a kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG2aκ antibodies. Mouse IgG2a kappa, Isotype Control maintains the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG2aκ subtype primary antibody, thus eliminating false positive signals caused by non-specific adsorption in immunological experiments and playing a core role in verifying experimental specificity. Mouse IgG2a kappa, Isotype Control can be applied to immunolocalization experiments such as immunofluorescence staining and immunohistochemistry in the field of cell biology, assisting in protein subcellular localization, cell structure analysis, and other research to ensure the reliability of experimental results.
Others  
Inflammation or Immune System Disease  
2
HY-K0017 Kinase Inhibitor Cocktail

MCE Kinase Inhibitor Cocktail controls the biological activity of kinases. This inhibitor is primarily used for Biochemicals applications.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Sample Preparation Kinase Inhibitor Cocktail

2
HY-P4910 Baceridin
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research.
Proteasome   Apoptosis  
1
HY-N1219 Stephanine
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer.
Apoptosis   Parasite  
Cancer   Infection   Inflammation or Immune System Disease  
1
HY-13545 ABT-510
ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD).
Apoptosis  
Cancer   Inflammation or Immune System Disease  
1
HY-P10908 H-20
H-20 is a PD-1 agonist. H-20 can be used in the research of chronic pain.
PD-1/PD-L1  
Lung Cancer  
1
HY-N3990 Hardwickiic acid
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases.
Sodium Channel   Parasite  
Infection   Neurological, Eye or Ear Disease  
1
HY-N0478 Neoline
Neoline (Bullatine B) is the active ingredient of the active ingredient (PA), which can be used to cure the disease. Neoline Flow Suppression Nav1.7 Electrical Flow Control (VGSC), improve diabetes mechanical pain sensitivity. Neoline has a list of compounds that can be used, research on its use, and the quality of its processing during processing in pain.
Others  
Neurological, Eye or Ear Disease   Glucose Metabolism  
1
HY-P990071 Fepixnebart
Fepixnebart (LY3016859) is a humanized monoclonal hIgG4 antibody, which binds and neutralizes only TGFα and epiregulin with high affinity. Fepixnebart can be used for the study of diabetic nephropathy and broad-spectrum chronic pain, including diabetic peripheral neuropathic pain (DPNP), signs and symptoms of osteoarthritis (OA), and chronic low back pain (CLBP).

Species: Human

EGFR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
1
HY-P3206 Serum thymic factor
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases.
ERK  
Inflammation or Immune System Disease   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pain   Glucose Metabolism   Obesity  
1
HY-P3206A Serum thymic factor acetate
Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases.
ERK  
Inflammation or Immune System Disease   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pain   Glucose Metabolism   Obesity  
1
HY-N0340 Scopolamine butylbromide
Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (Ki 83 nmol/L), hM2 (Ki 233 nmol/L), rat intestinal M3 (Ki 290 nmol/L) and hM3 (Ki 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer.
mAChR  
Pain   Experimental Autoimmune Encephalomyelitis   Gastric Ulcer   Muscle Relaxation and Spasm  
1
HY-N2067 Vanillyl alcohol
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases Bcl-2. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages.
Reactive Oxygen Species (ROS)   Bcl-2 Family  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Cardiovascular Disease  
1
HY-B1183 Hydrocortisone acetate
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
1
HY-R04602F FAM-MicroRNA Mimic Negative Control
FAM-MicroRNA Mimic Negative Control is a FAM labeled FAM-MicroRNA Mimic Negative Control (HY-R04602). MicroRNA Mimic Negative Control is a miRNA mimic of 21-nucleotides, and can be used as a negative control. The sequence of MicroRNA Mimic Negative Control is derived from cel-mir-239b. It has minimal sequence identity with miRNAs in human, mouse, and rat.
MicroRNA  
Cancer  
1
HY-172202A Control Liposomes(PBS)
Control Liposomes (PBS) can be used as control liposomes for Clodronate liposomes (HY-172202) without clodronate.
Biochemical Assay Reagents  
1
HY-N2071 Cedrol
Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.
Environmental Pollutants   Fungal   Apoptosis   Platelet-activating Factor Receptor (PAFR)   Cytochrome P450   Caspase  
Cancer   Digestive System Disease   Bacterial Infection   Fungal Infection   Digestive System Inflammation   Parkinson's Disease  
1
HY-N7108 7-Hydroxyflavone
7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active.
ERK   Keap1-Nrf2   Apoptosis   COX   Pyruvate Kinase   Lipoxygenase   Enterovirus   Virus Protease  
Colorectal Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Rheumatoid Arthritis  
1
HY-Y0892 4-Hydroxybenzyl alcohol
4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth.
Apoptosis   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation   Obesity  
1
HY-125474 Carrageenan
Carrageenan is an antiviral and anticancer agent. Carrageenan inhibits herpes simplex virus (HSV), HIV, and hepatitis A virus (HAV) by directly binding to the viral capsid to block the attachment of viruses such as HPV to HSPG factors on the cell surface. Carrageenan delays and arrests cell cycle progression, exhibits cytotoxicity against HeLa cancer cells, and can be applied to studies related to cervical cancer, genital warts, hepatitis A, and other conditions. Carrageenan also induces acute non-immune inflammation, triggers a three-phase inflammatory response involving the release of multiple proinflammatory mediators, and causes persistent edema, hyperalgesia, and neutrophil recruitment in mice.
Environmental Pollutants   HSV   HIV  
Cervical Cancer   HIV Infection   Hepatitis Virus Infection   HSV Infection  
1
HY-W250122 Glutamic acid sodium salt
Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders.
Biochemical Assay Reagents   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Apoptosis   HSP   Bcl-2 Family  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
1
HY-110004 ACEA
ACEA (short for arachidonyl-2'-chloroacetamide) is a synthetic organic compound that acts as an agonist of the cannabinoid receptor CB1. It is a chemical that affects the endocannabinoid system in the body, which regulates various physiological processes such as appetite, pain perception, mood, and memory.
Cannabinoid Receptor  
1
HY-P99221 Tanezumab
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia.

Species: Human

Trk Receptor  
Inflammation or Immune System Disease   Pain  
1
HY-164152 ADC Control Human IgG1-Deruxtecan (DAR 4)
ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E).
Antibody-Drug Conjugates (ADCs)   Topoisomerase  
Cancer  
1
HY-164152A ADC Control Human IgG1-Deruxtecan (DAR 8)
ADC Control Human IgG1-Deruxtecan (DAR 8) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E).
Antibody-Drug Conjugates (ADCs)   Topoisomerase  
Cancer  
1
HY-K0003 IP/Co-IP Elution Buffer

MCE IP Elution Buffer is a ready-to-use elution system specifically designed for IP/Co-IP experiments. It consists of an elution buffer and a matched neutralization buffer, enabling efficient and controlled elution of target proteins and ensuring compatibility with downstream analytical applications.

Protein Biology Immunoprecipitation Kit

1
HY-10448S1 Capsaicin-d3
Capsaicin-d3 is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.
Isotope-Labeled Compounds   TRP Channel   Autophagy   Apoptosis   Endogenous Metabolite  
Cancer  
/
HY-18101S BD-1063-d8 dihydrochloride
BD-1063-d8 dihydrochloride is the deuterium labeled BD1063 dihydrochloride (HY-18101A). BD-1063 dihydrochloride is a selective σ-1 receptor antagonist with inhibitory activity against TRPC5 and TRPM3. BD-1063 dihydrochloride exerts anti-hyperalgesic and anti-allodynic effects by inhibiting sustained calcium influx mediated by TRPC5 and TRPM3, and reverses the effects of Carrageenan (HY-125474). BD-1063 dihydrochloride also significantly reduces excessive ethanol self-administration behavior. BD-1063 dihydrochloride is widely used in studies on the mechanisms underlying neuropathic pain, inflammatory hyperalgesia, and alcohol abuse and dependence.
Isotope-Labeled Compounds   Sigma Receptor   TRP Channel  
/
HY-W009353S Tetrabutylammonium-d36 chloride
Tetrabutylammonium-d36 chloride (IPC-TBA-Cl-d36 chloride) is the deuterium labeled Tetrabutylammonium (chloride). Tetrabutylammonium chloride (IPC-TBA-Cl) is an organic compound commonly used as a catalyst and as an ionic liquid. It can be used to catalyze or promote reactions in certain organic reactions, and is widely used in batteries, solar cells and pigments. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
Isotope-Labeled Compounds  
/
HY-P992345 DS002
DS002 is a human monoclonal antibody targeting NGF/bNGF, with an IC50 of 6.60 nM against human NGF, 1.98 nM against rat NGF, and 8.46 nM against mouse NGF. DS002 blocks NGF-TrkA binding, interrupts pain signal transduction, inhibits TrkA-mediated downstream signaling pathways, and alters aromatic amino acid metabolic pathways. DS002 inhibits cancer cell proliferation. DS002 exerts a preventive effect on Paclitaxel-, Cisplatin- and Vincristine-induced peripheral neuropathy in rats. DS002 can be used in studies related to chronic pain and chemotherapy-induced peripheral neuropathy.

Species: Human

Trk Receptor  
Pain  
/
HY-182733M Plant Control Salt Solution
Plant Control Salt Solution is a control reagent specifically designed for plant physiological research. It is primarily used to study the absorption and selectivity of salts in plants and to analyze the effects of salt solutions on plants.
Biochemical Assay Reagents  
/
HY-167855S 1’-Epi Gemcitabine hydrochloride-13C,15N2
1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
Isotope-Labeled Compounds   P2Y Receptor  
Inflammation or Immune System Disease  
/
HY-N19281 Puberulin
Puberulin is a coumarin compound and an orally effective analgesic. Puberulin is present in Choisya ternata var. Sundance. Puberulin exerts analgesic activity against chemical and heat-induced pain agents in mouse models, and this activity does not involve opioid receptors or muscarinic receptors. Puberulin can be used in the research of neuropathic pain.
Drug Derivative  
Pain  
/
HY-W264038 4-Fluorohippuric acid
4-Fluorohippuric acid is a major metabolite of flupirtine with research potential against pain and epilepsy.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-17474AS Parecoxib-d5 sodium
Parecoxib-d5 sodium is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
Isotope-Labeled Compounds   COX  
Cancer   Inflammation or Immune System Disease  
/
HY-132184S 5,6-Epoxyeicosatrienoic acid-d11
5,6-Epoxyeicosatrienoic acid-d11 (5,6-EET-d11) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid is one of the four major epoxyeicosatrienoic acid (EET) isomers metabolized from Arachidonic acid (HY-109590). 5,6-Epoxyeicosatrienoic acid induces peripheral vasodilation and lowers blood pressure by inhibiting T-type calcium channels (Cav3.2: IC50 = 0.54 μM). 5,6-Epoxyeicosatrienoic acid causes vasoconstriction in hypoxic pulmonary blood vessels via activating Rho kinase in a membrane depolarization-dependent manner. 5,6-Epoxyeicosatrienoic acid induces mechanical pain by activating TRPA1. 5,6-Epoxyeicosatrienoic acid can be used in studies related to hypoxic pulmonary vasoconstriction, mechanical hyperalgesia and hypertension.
Isotope-Labeled Compounds   Adrenergic Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P10619 [Tyr6,D-Phe7,D-His9]-Substance P (6-11)
[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin NK1 receptor antagonist that antagonizes Histamine (HY-B1204) induced hyperalgesia.
Neurokinin Receptor  
Inflammation or Immune System Disease  
/
HY-P5907 Helianorphin-19
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-N0340R Scopolamine butylbromide (Standard)
Scopolamine butylbromide (Standard) is the analytical standard of Scopolamine butylbromide (HY-N0340). This product is intended for research and analytical applications. Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (Ki 83 nmol/L), hM2 (Ki 233 nmol/L), rat intestinal M3 (Ki 290 nmol/L) and hM3 (Ki 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer.
Reference Standards   mAChR  
Neurological, Eye or Ear Disease   Gastric Disease  
/
HY-P10169 Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scramble peptide of Acetyl-Calpastatin(184-210)(human) (HY-P1081). Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor.
Proteasome  
/
HY-133115AS N-Desmethylnefopam-d5 hydrochloride
N-Desmethylnefopam-d5 (hydrochloride) is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam hydrochloride is the main metabolite of Nefopam. N-Desmethylnefopam hydrochloride is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain.
Isotope-Labeled Compounds   β-catenin  
Neurological, Eye or Ear Disease  
/
HY-10448S4 Capsaicin-d7
Capsaicin-d7 is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects.
TRP Channel   Apoptosis   Endogenous Metabolite   Autophagy   Isotope-Labeled Compounds  
Cancer  
/
HY-17474S Parecoxib-d3
Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
Isotope-Labeled Compounds   COX  
Cancer   Inflammation or Immune System Disease  
/
HY-B2156S1 Menaquinone-4-13C6
Menaquinone-4-13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer  
/
HY-B0563BS Ropivacaine-d7 hydrochloride
Ropivacaine-d7 hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B). Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for neuropathic pain management in vivo.
Isotope-Labeled Compounds   Sodium Channel   Potassium Channel  
Neurological, Eye or Ear Disease  
/
HY-P2786A Phrixotoxin 2
Phrixotoxin 2 is a Kv4 family potassium channel inhibitor, with Ki values in rats of 120 nM for Kv4.2, 110 nM for Kv4.3, and 230 nM for Kv4.1. Phrixotoxin 2 mediates voltage-dependent inhibition of Kv4.2 and Kv4.3 currents, and voltage-independent inhibition of Kv4.1 currents. Phrixotoxin 2 fails to inhibit A-type K+ currents in visceral dorsal root ganglion neurons. Phrixotoxin 2 induces contraction of non-pregnant uterine smooth muscle and triggers orofacial cold hyperalgesia in rats. Phrixotoxin 2 can distinguish the contribution of Kv4 subunits to A-type K+ currents in different subsets of sensory neurons. Phrixotoxin 2 can be used in research related to chronic pain and trigeminal neuropathic pain.
Potassium Channel  
Muscle Disease   Chronic Pain  
/
HY-125527AS 17(R)-Resolvin D1-d5
17(R)-Resolvin D1-d5 (17(R)-RvD1-d5) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy.
Isotope-Labeled Compounds   TRP Channel  
Inflammation or Immune System Disease  
/
HY-P1020 Nocistatin(human)
Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
Prostaglandin Receptor  
Neurological, Eye or Ear Disease  
/
HY-P10471D MPSD control peptide
MPSD control peptide (MARCKS-ED control peptide) is a control peptide for MPSD peptide (HY-P10471). MPSD (MARCKS-ED) is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD can sense membrane curvature and recognize phosphatidylserine. MPSD can be utilized as biological probe to study membrane shape and lipid composition.
MARCKS   PKC  
/
HY-P2120 Pseudobactin A
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10.
Bacterial  
/
HY-P3839 Nocistatin
Nocistatin, a neuropeptide, is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a Gi/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-106224AS Orexin A-13C6,15N (human, rat, mouse) TFA
Orexin A-13C6,15N (human, rat, mouse) (Hypocretin-1-13C6,15N (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Isotope-Labeled Compounds   Orexin Receptor (OX Receptor)  
/
HY-P1319 Nociceptin(1-7)
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo.
Opioid Receptor  
Inflammation or Immune System Disease  
/
HY-134045 (-)-Anatoxin A
(-)-Anatoxin A is an enantiomer of (±)-Anatoxin A (HY-N2326). (-)-Anatoxin A is a neuronal nicotinic acetylcholine receptor agonist. (-)-Anatoxin A can be used for pain and inflammation research.

Source: cyanobacteria

nAChR  
Inflammation or Immune System Disease   Pain  
/
HY-W357142 3-Acetylumbelliferyl β-D-Glucopyranoside
3-Acetylumbelliferyl β-D-Glucopyranoside is a fluorogenic substrate for β-glucosidase and can be used as a positive control substrates for β-D-glucosidase.
Fluorescent Dye  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B1319S1 Pramocaine-d9 hydrochloride
Pramocaine-d9 (Pramoxine-d9) hydrochloride is the d9-labeled Pramocaine hydrochloride (HY-B1319). Pramocaine hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.
Isotope-Labeled Compounds   Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-B1462S1 Chlorzoxazone-13C
Chlorzoxazone-13C is the 13C labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
Cytochrome P450  
Inflammation or Immune System Disease  
/
HY-P11431 Cyclo(Gly-Pro)
Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the IGF-1. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice.
IGF-1R  
Inflammation or Immune System Disease   Pain  
/
HY-P1383A Rac1 Inhibitor F56, control peptide TFA
Rac1 Inhibitor F56, control peptide TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide TFA contains a Trp56 to Phe56 mutation. Rac1 Inhibitor F56, control peptide TFA has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs).
Ras  
/
HY-P3445 Anrikefon
Anrikefon is a peripherally restricted kappa opioid receptor (KOR) agonist, with an IC50 of 0.54 nM, an EC50 of 2.41 pM, and a Ka of 0.068 nM against human KOR, and it exhibits high selectivity over μ and δ opioid receptors. Anrikefon exerts analgesic effects by inhibiting behaviors associated with inflammatory, postoperative and neuropathic pain, and also exerts antipruritic effects by reducing itch-related behaviors. Anrikefon can be used in research on pain, pruritus, and pruritus associated with chronic kidney disease.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-B0383AS2 Almotriptan-d3 benzoate
Almotriptan-d3 benzoate (PNU180638 free base-d3) is deuterated labeled Almotriptan benzoate. Almotriptan benzoate is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan benzoate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan benzoate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan benzoate can be used in research related to migraine.
Isotope-Labeled Compounds   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-P991323 MEDI-1912
MEDI-1912 is a human monoclonal antibody (mAb) targeting NGF/bNGF. MEDI-1912 inhibits signaling through TrkA and p75 receptors. MEDI-1912 can be used in chronic pain research.

Species: Human

Trk Receptor   Neurokinin Receptor  
Inflammation or Immune System Disease  
/
HY-P5900 m3-Huwentoxin IV
m3-Huwentoxin IV (m3-HwTx-IV) is a potent NaV inhibitor with IC50s of 3.3, 6.8, 7.2, 8.4, 11.9 and 369 nM against hNaV1.7, hNaV1.6, hNaV1.3, hNaV1.1, hNaV1.2 and hNaV1.4, respectively in QPatch assay. m3-Huwentoxin IV dose-dependently suppresses spontaneous pain induced by the NaV1.7 activator OD1 in a rodent pain model.
Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-P2250 ELA RR>GG
ELA RR>GG (ELA-32 negative control), an ELABELA (ELA-32 human) mutant peptide, is inactive. ELA RR>GG is a negative control for ELABELA (HY-P2196).
Apelin Receptor (APJ)  
/
HY-B1430S Butamben-d9
Butamben-d9 is the deuterium labeled Butamben. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions.
Isotope-Labeled Compounds   Calcium Channel   Sodium Channel   Potassium Channel  
Neurological, Eye or Ear Disease  
/
HY-P11803 KAI-1678
KAI-1678 is a selective protein kinase Cε (PKCε) inhibitor that competitively blocks the binding of PKCε to its anchoring protein RACK. KAI-1678 attenuates the responses of nociceptive neurons in rodent neuropathic pain models. KAI-1678 can be used in research related to moderate to severe postoperative pain, neuropathic pain, and postherpetic neuralgia.
PKC  
Pain  
/
HY-P992012 CA1001
CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.

Species: Human

Opioid Receptor  
Melanoma   Pain  
/
HY-P10767 MD01-67
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with Ki of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models.
Neurotensin Receptor  
Neurological, Eye or Ear Disease  
/
HY-B0383AS Almotriptan hydrochloride-d6
Almotriptan-d6 (PNU180638-d6) hydrochloride is the deuterium labeled Almotriptan hydrochloride. Almotriptan hydrochloride is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan hydrochloride shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan hydrochloride induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan hydrochloride can be used in research related to migraine.
Isotope-Labeled Compounds   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-P992358 GSK2394002
GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys.

Species: Human

ADAMTS  
Cardiovascular Disease  
/
HY-P5163 NMB-1
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC50: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain.
Others  
Inflammation or Immune System Disease  
/
HY-P1399 Pep2m, myristoylated
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).
PKC  
Neurological, Eye or Ear Disease  
/
HY-P1319A Nociceptin(1-7) TFA
Nociceptin (1-7) TFA is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) TFA is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) TFA combines with nociceptin reduces hyperalgesia in vivo.
Opioid Receptor  
Inflammation or Immune System Disease  
/
HY-P1213A JKC363 TFA
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-D3172 BD-105
BD-105 (Glucagon Yellow) is a glucagon-binding fluorescent probe with a KD value of 13.3 μM. BD-105 exhibits changes in fluorescence intensity upon interaction with glucagon, and colocalizes with glucagon in cells and tissues. BD-105 is a selective cell stain that labels glucagon-secreting cells without staining insulin-secreting cells or non-endocrine control cells. BD-105 serves as an imaging reagent for glucagon in live cells and tissues (Ex/Em = 540 nm/580 nm).
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-B0168AS Milnacipran-d5 hydrochloride
Milnacipran-d5 hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia).
Isotope-Labeled Compounds   Serotonin Transporter   PERK  
Neurological, Eye or Ear Disease  
/
HY-N12694 3-O-Methylellagic acid-4′-O-α-L-rhamnopyranoside
3-O-Methylellagic acid-4′-O-α-L-rhamnopyranoside is an ellagic acid glycoside compound that can be isolated from the stem bark of Aphananthe aspera and can be used for the research of inflammation and pain.
Others  
Inflammation or Immune System Disease  
/
HY-N19801 N-Palmitoyl-D-glucosamine
N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds MD-2 with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy.

Source: Pseudomonas aeruginosa

Toll-like Receptor (TLR)   NF-κB   Interleukin Related   TNF Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-155236 Ancistrotecine B
Ancistrotecine B (Compound 2) is a Nav1.7 channel inhibitor (IC50: 0.73 μM). Ancistrotecine B relieves inflammatory pain in mice.
Sodium Channel  
Inflammation or Immune System Disease  
/
HY-P1020A Nocistatin(human) TFA
Nocistatin (human) TFA blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2.
Prostaglandin Receptor  
Neurological, Eye or Ear Disease  
/
HY-W702016 Bupivacaine-d9 hydrochloride
Bupivacaine-d9 hydrochloride is the deuterium labeled Bupivacaine hydrochloride (HY-B0405A). Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.
Sodium Channel  
Cancer  
/
HY-17447SA Tranylcypromine-d5 hydrochloride
Tranylcypromine-d5 (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis.
Monoamine Oxidase   Histone Demethylase  
Neurological, Eye or Ear Disease  
/
HY-143797S Almotriptan-d6 maleate
Almotriptan-d6 (PNU180638-d6) maleate is the deuterium labeled Almotriptan maleate. Almotriptan malate is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan malate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan malate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan malate can be used in research related to migraine.
Isotope-Labeled Compounds   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-P10088 Mouse TREM-1 SCHOOL peptide, control
Mouse TREM-1 SCHOOL peptide, control is a negative control of Mouse TREM-1 SCHOOL peptide.
TREM receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-17474S1 Parecoxib-d5
Parecoxib-d5 (SC 69124-d5) is deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
Isotope-Labeled Compounds   COX  
Cancer   Inflammation or Immune System Disease  
/
HY-W011777S Tricaine-d5 methanesulfonate
Tricaine-d5 methanesulfonate is the deuterium labeled Tricaine methanesulfonate (HY-W011777). Tricaine methanesulfonate (MS-222) is a commonly used agent that can suppress or relieve pain. agent for immobilization of aquatic species. Tricaine methanesulfonate, the most widely used agent that can suppress or relieve pain. in fish, has been shown to induce embryotoxic effects in zebrafish.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-N1478R Gardenoside (Standard)
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study.
Reference Standards   P2X Receptor   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-N2258R Poncirin (Standard)
Poncirin (Standard) is the analytical standard of Poncirin. This product is intended for research and analytical applications. Poncirin is isolated from Poncirus trifoliata with anti-inflammory activites. Poncirin significantly reduces mechanical hyperalgesia and allodynia in Complete Freund’s Adjuvant (CFA)-induced inflammatory pain models.
Reference Standards   Apoptosis  
Inflammation or Immune System Disease  
/
HY-18732AR L-NMMA acetate (Standard)
L-NMMA (Tilarginine) acetate (Standard) is the analytical standard of L-NMMA acetate (HY-18732A). This product is intended for research and analytical applications. L-NMMA (Tilarginine) acetate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA acetate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA acetate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA acetate is applicable to research related to nociception, bone cancer pain, and myopia.
Reference Standards   NO Synthase  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-101546A Cavidine
Cavidine ((+)-Cavidine) is an analgesic and anti-inflammatory agent. Cavidine can be isolated from Corydalis ternata f. yanhusuo (Y.H.Chou & Chun C.Hsu) Y.C.Zhu. Cavidine reduces the expression of inflammatory factors IL-1β, IL-6 and TNF-α, and inhibits calcium ion influx. Cavidine inhibits the phosphorylation of p38 and ERK1/2. Cavidine increases mechanical and thermal pain thresholds in chronic pain models. Cavidine can be used for the research of chronic pain.
p38 MAPK   ERK   Interleukin Related  
Inflammation or Immune System Disease   Chronic Pain  
/
HY-N0388R Gelsemine (Standard)
Gelsemine (Standard) is the analytical standard of Gelsemine. This product is intended for research and analytical applications. Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.
Reference Standards   Others  
Neurological, Eye or Ear Disease  
/
HY-P1626 Acetyl tetrapeptide-15
Acetyl tetrapeptide-15 is a synthetic peptide. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. Acetyl tetrapeptide-15 is used in the cosmetics for sensitive skin.
Opioid Receptor  
Depression   Pain  
/
HY-P3223A Biphalin acetate
Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-P991622 MNAC13
MNAC13 is a kind of mouse IgG1 chimeric antibody, targeting to human TrkA. MNAC13 inhibits the NGF dependent signaling pathway by specifically binding to TrkA receptors. MNAC13 has good analgesic effect and long-lasting efficacy. MNAC13 can be used for researches on inflammatory and chronic pain.

Species: Human

Trk Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-145491 Resolvin D5
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis.
ERK   NF-κB   CCR  
Rheumatoid Arthritis  
/
HY-N3710 Dehydrocrenatidine
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.
JAK   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P991711 Povovetug
Povovetug is a humanized IgG1κ chimeric monoclonal antibody inhibitor targeting NGF/bNGF. Povovetug has a significant analgesic activity. Povovetug can be used for central neuroinflammation like chronic radicular pain research.

Species: Human

Trk Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-17357S Nepafenac-d5
Nepafenac-d5 (AHR-9434-d5; AL-6515-d5) is the deuterium labeled Nepafenac (HY-17357). Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.
Isotope-Labeled Compounds   Prostaglandin Receptor   COX  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W101299 N-Acetyl-D-allo-isoleucine
N-Acetyl-D-allo-isoleucine is an amino acid derivative. N-Acetyl-D-allo-isoleucine is promising for research of amino acid metabolism, such as abnormal isoleucine metabolism.
Amino Acid Derivatives  
Metabolic or Endocrine Disease  
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HY-121975 N-Cyclohexanecarbonylpentadecylamine
N-Cyclohexanecarbonylpentadecylamine (Compound 1) is an inhibitor of N-Acylethanolamine hydrolyzing acid amidase (NAAA) with an IC50 of 4.5 μM. N-Cyclohexanecarbonylpentadecylamine can be used in the research of inflammation and pain.
Ceramidase  
Inflammation or Immune System Disease  
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HY-108449S Acoltremon-d3
Acoltremon-d3 (WS-12-d3) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.
Isotope-Labeled Compounds   TRP Channel  
Neurological, Eye or Ear Disease  
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HY-N11080 Cucurbitacin R
Cucurbitacin R is a cucurbitacin. Cucurbitacin R can be isolated from the roots of Cayaponia tayuya. Cucurbitacin R can be used for the research of pain and inflammation.
Others  
Inflammation or Immune System Disease  
/
HY-P10358 TAT-CBD3A6K
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-P10471E MPSD control peptide TFA
MPSD control peptide (MARCKS-ED control peptide) TFA is the control peptide of MPSD (HY-P10471). MPSD (MARCKS-ED) is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS).
MARCKS  
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HY-D148410F Cy5-Zorevunensen negative control
Cy5-Zorevunensen negative control (Cy5-STK-001 negative control) is an antisense oligonucleotide labeled with the fluorescent molecule Cy5, which can be used as a negative control for Zorevunersen (HY-148410).
Fluorescent Dye  
Neurological, Eye or Ear Disease  
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HY-B1901S Eperisone-d10 hydrochloride
Eperisone-d10 (hydrochloride) is the deuterium labeled Eperisone hydrochloride. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[2 .
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
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HY-P1073 ProTx-I
ProTx-I is a toxin derived from Thrixopelma pruriens and a peptide inhibitor targeting TTX-resistant sodium channels. ProTx-I interacts with voltage sensors of multiple domains such as NaV1.7, reduces neuronal excitability through allosteric modulation of channel gating and alteration of voltage dependence. The IC50 values of ProTx-I against human NaV1.7, NaV1.2, NaV1.6, and NaV1.5 are 95 nM, 104 nM, 21 nM, and 358 nM, respectively; ProTx-I also potently inhibits Ba2+ currents of hCav3.1, while its inhibitory potency against hCav3.2 is approximately 160-fold lower. ProTx-I is applicable to the research of chronic pain.
Calcium Channel   Potassium Channel   Sodium Channel   TRP Channel  
Cancer   Neurological, Eye or Ear Disease  
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HY-139201E Poly-D-lysine hydrobromide (MW 150000-300000)
Poly-D-lysine hydrobromide (MW 150000-300000) is a synthetic polymer composed of D-lysine residues and is one of the most widely used matrices in neural cell culture applications. Poly-D-lysine hydrobromide (MW 150000-300000) can be used as a non-specific cell adhesion enhancer. Poly-D-lysine hydrobromide (MW 30000-70000) is an orally active CaSR agonist peptide that indirectly activates the 5-HT₃ receptor signaling pathway, delaying gastric emptying and thereby slowing the rate at which glucose enters the small intestine and is absorbed.
CaSR   5-HT Receptor  
Glucose Metabolism  
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HY-106224AS1 Orexin A-13C18,15N3 (human, rat, mouse) TFA
Orexin A-13C18,15N3 (human, rat, mouse) ((Hypocretin-1-13C18,15N3 (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Isotope-Labeled Compounds   Orexin Receptor (OX Receptor)  
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HY-P1399A Pep2m, myristoylated TFA
Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).
PKC  
Cancer   Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
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HY-76711S Naltrexone-d4
Naltrexone-d4 is deuterium labeled Naltrexone (HY-76711). Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight.
Isotope-Labeled Compounds   Opioid Receptor  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
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HY-126941 Hecogenin acetate
Hecogenin acetate is an orally active steroid saponin aglycone with extensive biological activities. Hecogenin acetate inhibits the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizes TRPA1/TRPM8 channels, inhibits the production of pro-inflammatory cytokines, and has anti-inflammatory and analgesic effects. Hecogenin acetate inhibits the production of ROS and the activation of NLRP3 inflammasome; downregulates the expression of MMP-2, and has neuroprotective and anti-tumor activities. Hecogenin acetate enhances gastric mucosal defense and promotes ulcer healing. Hecogenin acetate can be used in combination with certain antibiotics to regulate bacterial efflux pumps and restore antibiotic sensitivity.
ERK   MMP   Reactive Oxygen Species (ROS)   NF-κB   p38 MAPK   NOD-like Receptor (NLR)   TRP Channel   TNF Receptor   Interleukin Related  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Bacterial Infection   Urologic Disease   Gastric Ulcer  
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HY-N6663 3-Carene
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation.
Environmental Pollutants   COX  
Rheumatoid Arthritis  
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HY-W357818 Glycinexylidide
Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease.
Sodium Channel   NF-κB   MEK   ERK   Drug Metabolite  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
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HY-P1213 JKC363
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
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HY-P4124 Pepinh-Control
Pepinh-Control is a negative control peptide.
Others  
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HY-W009235 Tetraethylammonium p-toluenesulfonate
Tetraethylammonium p-toluenesulfonate p-toluenesulfonate is an organic compound commonly used as a catalyst and surfactant. It can be used to catalyze or promote reactions in certain organic synthesis reactions, and is widely used in the fields of surfactants, lubricants and antistatic agents. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
Biochemical Assay Reagents  
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HY-N0412 Sesamoside
Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain.
PERK   JNK   TNF Receptor   Interleukin Related  
Inflammation or Immune System Disease   Pain  
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HY-P3499 Dolcanatide
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research.
Guanylate Cyclase  
Inflammation or Immune System Disease  
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HY-A0057S Gabapentin-d4
Gabapentin-d4 is the deuterium labeled Gabapentin. Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.
Calcium Channel  
Neurological, Eye or Ear Disease  
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HY-B0405S Bupivacaine-d9
Bupivacaine-d99 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
Isotope-Labeled Compounds   iGluR   Sodium Channel   Calcium Channel   Potassium Channel  
Neurological, Eye or Ear Disease  
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HY-W016656 4-Phenylurazole
4-Phenylurazole (4-Phenyl-1,2,4-triazolidine-3,5-dione) is an important intermediate. 4-Phenylurazole also serves as a photographic emulsion stabilizer and a lubricant additive.
Drug Intermediate  
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HY-DY1081 DAPI dihydrochloride (solution)
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride (solution) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
Solvent and concentration: ddH2O: 5 mg/mL
Sodium Channel   DNA Stain  
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HY-W008951 Ethylenediaminetetra(methylenephosphonic acid)
Ethylenediaminetetramethylenephosphonic acid (EDTMP) is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with 153Sm and 177Lu. Ethylenediaminetetramethylenephosphonic acid is used to study palliative therapy for pain associated with multiple bone metastatic cancers.
Radionuclide-Drug Conjugates (RDCs)  
Pain   Multiple Myeloma  
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HY-150150F Cy3-siRNA Negative Control
Cy3-siRNA Negative Control is Cy3-labeled SiRNA Negative Control (HY-150150). Cy3-siRNA Negative Control can be used for easy visualization and assessment of transfection efficiency.
Small Interfering RNA (siRNA)  
Inflammation or Immune System Disease  
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HY-N5025 Bullatine A
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression.
P2X Receptor   Apoptosis   ERK   p38 MAPK   c-Myc   NF-κB   Reactive Oxygen Species (ROS)  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Neurodegenerative Disease   Depression   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
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HY-N0637A (±)-Eriodictyol
(±)-Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. (±)-Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. (±)-Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. (±)-Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. (±)-Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases.
Melanocortin Receptor   TRP Channel  
Metabolic or Endocrine Disease  
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HY-N6967 Levomenol
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active.
Environmental Pollutants   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
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HY-111615 J-2156
J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats.
Somatostatin Receptor  
Neurological, Eye or Ear Disease  
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HY-W001992 2,6-Dichloro-3-nitropyridine
2,6-Dichloro-3-nitropyridine is a starting compound for the synthesis of a sulfide analog of Flupirtine (HY-17001A) with KV7.2/3 channel opening activity. 2,6-Dichloro-3-nitropyridine can be used in pain research.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-N0388 Gelsemine
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.
Others  
Neurological, Eye or Ear Disease  
/
HY-164154 ADC Control Human IgG1-vcMMAF
ADC Control Human IgG1-vcMMAF is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is MC-Val-Cit-PAB-MMAF (vcMMAF; HY-112786).
Antibody-Drug Conjugates (ADCs)   Microtubule/Tubulin  
Cancer  
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HY-111615A J-2156 TFA
J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 TFA has anti-inflammatory activity and it is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats.
Somatostatin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
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HY-P99112 Satralizumab
Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research.

Species: Human

Interleukin Related  
Cancer   Inflammation or Immune System Disease  
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HY-121615 α-Phellandrene
α-Phellandrene (alpha-Phellandrene) is an orally active monoterpenoid and insecticide. α-Phellandrene can be isolated from plant essential oils. α-Phellandrene induces Apoptosis and Autophagy. α-Phellandrene promotes cAMP signaling pathway and increases NO production. α-Phellandrene has anti-inflammatory and anticancer (sarcoma) activities. α-Phellandrene shows insecticidal activity against Lucilia cuprina L3. α-Phellandrene reduces mechanical hyperalgesia.
Environmental Pollutants   Apoptosis   NO Synthase   Insecticide   Autophagy  
Infection   Neurological, Eye or Ear Disease   Digestive System Disease   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation  
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HY-113093 Ethyl glucuronide
Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4.
Endogenous Metabolite   Toll-like Receptor (TLR)  
Cancer   Pain   Autoimmune Disease  
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HY-W008145 Sodium tetrachloropalladate(II)
Sodium tetrachloropalladate(II) is an organic compound commonly used as a catalyst and as a raw material for dye production. It can be used to catalyze or promote reactions in certain chemical reactions, and is widely used in the fields of organic synthesis and dye preparation. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
Biochemical Assay Reagents  
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HY-135013 Umbellulone
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.
TRP Channel  
Pain  
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HY-14751 Rolapitant
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.
Neurokinin Receptor  
Cancer   Neurological, Eye or Ear Disease   SARS-CoV-2 Infection  
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HY-W007432 RuPhos
RuPhos is a Buchwald ligand. In aqueous Suzuki-Miyaura catalytic transfer polymerization, RuPhos forms inactive Pd (RuPhos)2 with palladium and inhibits diffusion to improve polymerization controllability. RuPhos additional addition in anhydrous Kumada polymerization exacerbates catalyst deactivation and chain transfer, significantly impairing polymerization control.
Biochemical Assay Reagents  
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HY-P99143 Anti-Mouse NK1.1 Antibody (PK136)
Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1 IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH).

Species: Mouse

Neurokinin Receptor   NF-κB   STAT  
Digestive System Disease   Digestive System Inflammation  
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HY-P10746 EB1002
EB1002 is a highly selective, long-acting NK2R agonist. EB1002 exerts central appetite suppression, increases peripheral energy expenditure and enhances insulin sensitivity, which effectively reduces body weight, improves glucose and lipid metabolism, with favorable safety profiles. EB1002 can be used for research on diseases such as obesity and type 2 diabetes.
Neurokinin Receptor  
Metabolic or Endocrine Disease  
/
HY-164153 ADC Control Human IgG1-vcMMAE (DAR4, solution)
ADC Control Human IgG1-vcMMAE (DAR4, solution) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAE and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is vcMMAE (HY-15575).
Antibody-Drug Conjugates (ADCs)   Microtubule/Tubulin  
Cancer  
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HY-P99002 Human IgG2 kappa, Isotype Control
Human IgG2 kappa, Isotype Control is a human monoclonal antibody serving as an isotype control for human IgG2κ antibodies such as Cepeprubart (HY-P990732) and Ersodetug (HY-P990712). Human IgG2 kappa, Isotype Control can be used in T cell research.
Others  
Inflammation or Immune System Disease  
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HY-30536 tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate
tert-Butyl 3,9-diazaspiroundecane-3-carboxylate is a 3,9-diazaspiroundecane-based building block and precursor for synthesizing γ-aminobutyric acid type A (GABAA) receptor antagonists.
Drug Intermediate   GABA Receptor   PROTAC Linkers  
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HY-P701661 CKS1 Protein, Human
CKS1 Protein is vital, binding to the catalytic subunit of cyclin-dependent kinases and serving as an essential factor for their biological function. Forming a homohexamer, CKS1's potential to bind six kinase subunits underscores intricate regulatory mechanisms. This highlights CKS1's importance in modulating cyclin-dependent kinase activity, emphasizing its crucial role in facilitating the proper functioning of these key cellular regulators. CKS1 Protein, Human is the recombinant human-derived CKS1 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Enzymes & Regulators

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HY-P702779 CDK1 Protein, Human (Active, sf9)
The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9) is the recombinant human-derived CDK1, expressed by Sf9 insect cells, with tag-free. The total length of CDK1 Protein, Human (sf9) is 297 a.a..

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CMGC Cyclin-Dependent Kinases (CDKs) CDK Cyclin Dependent Kinase 1 (CDK1)

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HY-P71168 NPDC-1 Protein, Human (HEK293, His)
NPDC-1 protein critically hinders oncogenic transformation in neural and non-neural cells, suppressing neural cell proliferation. Its multifaceted impact extends to transcriptional regulation, emphasizing its role as a regulator with implications for mitigating oncogenic processes and modulating cellular proliferation in diverse cell systems. NPDC-1 Protein, Human (HEK293, His) is the recombinant human-derived NPDC-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P75668 CDK1 Protein, Human (Inactive, sf9, GST)
The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9, GST) is the recombinant human-derived CDK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CMGC Cyclin-Dependent Kinases (CDKs) CDK Cyclin Dependent Kinase 1 (CDK1)

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HY-P702775 Envelop VLP Control (HEK293)
Envelop VLP Control (HEK293) is recommended for the control of CCR2b Protein-VLP, Human (HEK293) (HY-P77589), CD20/MS4A1 Protein-VLP, Human (HEK293)(HY-P78543), Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293)(HY-P78368), etc. For more control information on other VLP proteins, please refer to the description of the specific protein.

Species: Virus; Source: HEK293

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HY-P701236 Virus-Like Particles (VLPs) isotype control Protein (HEK293)
Virus-Like Particles (VLPs) isotype control Protein (HEK293) is an empty virus-like particle, self-assembled from viral envelope or capsid proteins, and serves as a VLP control. Virus-Like Particles (VLPs) isotype control Protein (HEK293) can be used as a control for products such as CD133/PROM1 Protein-VLP, Human (HEK293, His) (HY-P78732), and Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His) (HY-P700472). For more information on controls for other VLP proteins, please refer to the specific protein description. Virus-Like Particles (VLPs) isotype control Protein (HEK293) is a recombinant Virus-Like Particles (VLPs) isotype control Protein expressed by HEK293.

Species: Virus; Source: HEK293

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HY-P75669 CDK1 Protein, Mouse (sf9, His-GST)
The CDK1 protein centrally controls the eukaryotic cell cycle, coordinating the G2-M transition and mitotic events. It interacts with a variety of cell cycle proteins, phosphorylates a variety of substrates, and affects cell cycle regulation, DNA repair, and apoptosis. CDK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Mouse; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CMGC Cyclin-Dependent Kinases (CDKs) CDK Cyclin Dependent Kinase 1 (CDK1)

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HY-P705590 EIF2AK4 Protein, Human (sf9, His-GST)

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Other Kinases PEK EIF2AK4/GCN2

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HY-P705433 Virus-Like Particles (VLPs) isotype control Protein (HEK293, solution)
Virus-Like Particles (VLPs) isotype control Protein (HEK293, solution) is recommended for the control of CCR7/CD197 Protein-VLP, Human (HEK293)(HY-P704232), Claudin-9/CLDN9 Protein-VLP, Human (HEK293)(HY-P703890), etc. For more control information on other VLP proteins, please refer to the description of the specific protein.

Species: Virus; Source: HEK293

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HY-P705435 Virus-Like Particles (VLPs) isotype control Protein (HEK293, GFP, solution)
Fluorescent VLP with a GFP tag, self-assembles from viral envelope/capsid proteins, serving as a control for VLPs displaying membrane proteins. Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening.

Species: Virus; Source: HEK293

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HY-P89424 Mouse IgA Isotype Control Antibody (YA8863)
Mouse IgA Isotype Control Antibody (YA8863) is a Non-conjugated and Mouse origined monoclonal antibody, It can be used as an Mouse IgA isotype control.

Host: Mouse; Reactivity: species independent

Monoclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89462 Normal Chicken IgY Isotype Control Antibody
Normal Chicken IgY Isotype Control Antibody is a Non-conjugated and Chicken origined monoclonal antibody, It can be used as an Chicken IgY isotype control.

Host: Chicken; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89463 Normal Chicken IgY Isotype Control Antibody (APC)
Normal Chicken IgY Isotype Control Antibody (APC) is a APC conjugated and Chicken origined monoclonal antibody, It can be used as an Chicken IgY isotype control.

Host: Chicken; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89464 Normal Chicken IgY Isotype Control Antibody (FITC)
Normal Chicken IgY Isotype Control Antibody (FITC) is a FITC conjugated and Chicken origined monoclonal antibody, It can be used as an Chicken IgY isotype control.

Host: Chicken; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89465 Normal Chicken IgY Isotype Control Antibody (PE)
Normal Chicken IgY Isotype Control Antibody (PE) is a PE conjugated and Chicken origined monoclonal antibody, It can be used as an Chicken IgY isotype control.

Host: Chicken; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89466 Normal Chicken IgY Isotype Control Antibody (PerCP)
Normal Chicken IgY Isotype Control Antibody (PerCP) is a PerCP conjugated and Chicken origined monoclonal antibody, It can be used as an Chicken IgY isotype control.

Host: Chicken; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89467 Normal Goat IgG Isotype Control Antibody
Normal Goat IgG Isotype Control Antibody is a Non-conjugated and Goat origined monoclonal antibody, It can be used as an Goat IgG isotype control.

Host: Goat; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-P89487 Normal Rat IgG Isotype Control Antibody
Normal Rat IgG Isotype Control Antibody is a Non-conjugated and Rat origined monoclonal antibody, It can be used as an Rat IgG isotype control.

Host: Rat; Reactivity: species independent

Polyclonal Antibodies Isotype Control Antibodies Primary Antibodies

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HY-K2004 Trypan Blue Staining Solution (0.4%)

MCE Trypan Blue Staining Solution (0.4%) is suitable for viability assessment of most adherent and suspension cell lines. It is commonly used for cell culture quality control, evaluation of cellular responses following drug treatment, and viability measurements after cell thawing and recovery.

Cell Biology Cell Analysis Cell Proliferation and Cytotoxicity

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HY-K6303 Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit

MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

Cell Biology 3D Cell Culture PSC Induction Product Series

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Keywords

hyperalgesia | allodynia | central sensitization | nociceptive circuits | spinal dorsal horn | descending pain control | pain plasticity | chronic pain