Myc - myelocytomatosis oncogene Gene
Also Known as Myc2; Nird; Niard; bHLHe39
生物種: Mus musculus
About Myc
This gene has 7 transcripts (splice variants), 217 orthologues, 4 paralogues and is associated with 81 phenotypes. Broad expression in ovary adult (RPKM 36.6), thymus adult (RPKM 28.3) and 22 other tissues.
Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Myc Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001177352.1 | NP_001170823.1 | myc proto-oncogene protein isoform b |
| NM_010849.4 | NP_034979.3 | myc proto-oncogene protein isoform a |
| NM_001177354.1 | NP_001170825.1 | myc proto-oncogene protein isoform b |
| NM_001177353.1 | NP_001170824.1 | myc proto-oncogene protein isoform c |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables DNA binding |
IDA
IDA: Inferred from direct assay
|
12970171 | MGI |
| enables RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
18625840 | MGI |
| enables cis-regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
15511642 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9764821 | MGI |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
22328504 | MGI |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of Myc-Max complex |
IPI
IPI: Inferred from physical interaction
|
20434984 | MGI |
| located in axon |
IDA
IDA: Inferred from direct assay
|
10482234 | MGI |
| located in euchromatin |
IDA
IDA: Inferred from direct assay
|
22723415 | MGI |
| located in nuclear body |
IDA
IDA: Inferred from direct assay
|
15735755 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11872843 | MGI |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
22328504 | MGI |
| located in spindle |
IDA
IDA: Inferred from direct assay
|
15509711 | MGI |
Myc Protein Structure
Myc_N: pfam01056 (1 - 344)
bHLHzip_c-Myc: cd11458 (350 - 433)
- 0
- 100
- 200
- 300
- 400
- 439 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myc proto-oncogene protein |
|
Myc Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
Myc | P01108 | Max | Mus musculus | P28574 | 20946988 | |
|
Intra
|
Myc | P01108 | Max | Mus musculus | P28574 | 20946988 | |
|
Intra
|
Myc | P01108 | Max | Mus musculus | P28574 | 20434984 | |
|
Intra
|
Myc | P01108 | Trim32 | Mus musculus | Q8CH72 | 19269368 |