BRD4 - bromodomain containing 4 Gene

Also Known as CAP; MCAP; HUNK1; HUNKI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23476

About BRD4

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,235,519-15,332,539 (from NCBI)

This gene has 13 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 111 phenotypes. Ubiquitous expression in placenta (RPKM 10.8), testis (RPKM 9.2) and 25 other tissues.

Summary

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during Mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

BRD4 Products (11)

mRNA	Protein	Name
NM_001379292.1	NP_001366221.1	bromodomain-containing protein 4 isoform short
NM_001330384.2	NP_001317313.1	bromodomain-containing protein 4 isoform 3
XM_047438543.1	XP_047294499.1	bromodomain-containing protein 4 isoform X4
XM_047438541.1	XP_047294497.1	bromodomain-containing protein 4 isoform X2
XM_047438542.1	XP_047294498.1	bromodomain-containing protein 4 isoform X3
XR_007066712.1
NM_001379291.1	NP_001366220.1	bromodomain-containing protein 4 isoform long
XM_047438544.1	XP_047294500.1	bromodomain-containing protein 4 isoform X4
XM_047438540.1	XP_047294496.1	bromodomain-containing protein 4 isoform X1
NM_058243.3	NP_490597.1	bromodomain-containing protein 4 isoform long
NM_014299.3	NP_055114.1	bromodomain-containing protein 4 isoform short

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables P-TEFb complex binding	IDA IDA: Inferred from direct assay	17690245	GOA
enables RNA polymerase II C-terminal domain binding	IDA IDA: Inferred from direct assay	22509028	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IMP IMP: Inferred from mutant phenotype	22509028	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20871596	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21555454	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	23086925	GOA
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	20871596	GOA
enables p53 binding	IDA IDA: Inferred from direct assay	23317504	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17023018	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	23086925	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	21555454	GOA
enables transcription coregulator activity	IMP IMP: Inferred from mutant phenotype	24360279	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23728299	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	23728299	GOA
involved in negative regulation by host of viral transcription	IDA IDA: Inferred from direct assay	17690245	GOA
involved in negative regulation of DNA damage checkpoint	IMP IMP: Inferred from mutant phenotype	23728299	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21555454	GOA
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	10938129	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19103749	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23086925	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	19103749	GOA
acts upstream of or within positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18039861	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	19103749	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18039861	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome	IDA IDA: Inferred from direct assay	23728299	GOA
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	10938129	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20871596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD4 Protein Structure

Bromodomain

0
300
600
900
1200
1362 a.a.

Protein Preferred Names	Protein Names
bromodomain-containing protein 4	chromosome-associated protein mitotic chromosome-associated protein

BRD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	BRD4	O60885	E2	Human papillomavirus	P03120	SLC	22761572
Cross	BRD4	O60885	E2	Human papillomavirus	P03120	Anti Tag CoIP	15109495
Cross	BRD4	O60885	E2	Human papillomavirus	P03120	Y2H	18305892
Intra	BRD4	O60885	TWIST1	Homo sapiens	Q15672	NMR	24525235
Intra	BRD4	O60885	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	BRD4	O60885	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Cross	BRD4	O60885	E2	Human papillomavirus	P04015	Affinity Chrom	17023018
Cross	BRD4	O60885	E2	Human papillomavirus	P04015	SLC	22761572
Cross	BRD4	O60885	E2	Human papillomavirus	P06790	SLC	22761572
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	Anti Bait CoIP	19103749
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	Pull Down	23686307
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	NMR	22645123
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	Anti Bait CoIP	23686307
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	X-Ray Diffraction	23686307
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Pull Down	24360279
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Anti Bait CoIP	24360279
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Anti Tag CoIP	24360279
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BRD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7846	BRD4 Protein, Human (His-Flag)	O60885-1 (E49-E460)	≥ 90%, as determined by reducing SDS-PAGE.

BRD4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80976	BRD4 Antibody (YA3486)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80976A	BRD4 Antibody (YA3486)(PBS only)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Rhabdomyosarcoma
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Cornelia De Lange Syndrome 1	De Lange Syndrome CDLS1 Cdl Cdls Typus Degenerativus Amstelodamensis Brachmann-De Lange Syndrome Bdls Amstelodamensis Typus Degenerativus Cornelia De Lange Syndrome, Type 1
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Ureteral Obstruction
Heterophyiasis	Heterophyes Infectious Disease
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12863	Pelabresib	Inhibitor	99.95%	Phase 3
HY-111916	ODM-207	Inhibitor	99.58%	Phase 2
HY-13030	(+)-JQ-1	Inhibitor	99.91%	Phase 1
HY-112090	ABBV-744	Inhibitor	99.97%	Phase 1
HY-100015	Mivebresib	Inhibitor	99.29%	Phase 1
HY-117286	(S)-JQ-35	Inhibitor	99.46%	Phase 1
HY-117491	BRD4 Inhibitor-10	Inhibitor	99.52%	Phase 1

Pre-clinical Phase

Bioactive Molecules (264)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100972	ARV-771	Degrader	99.87%	Unkown
HY-101838	dBET1	Inhibitor	99.24%	Unkown
HY-78695	JQ-1 carboxylic acid	Inhibitor	99.69%	Unkown
HY-129937A	GNE-987	Inhibitor	99.98%	Unkown
HY-136570	GSK778	Inhibitor	99.14%	Unkown
HY-122826	ZXH-3-26	Inhibitor	99.53%	Unkown
HY-14443	XMD8-92	Inhibitor	99.48%	Unkown
HY-100482	CPI-637	Inhibitor	99.94%	Unkown
HY-176521	AR/BRD4 RIPTAC-1	Inhibitor	98.65%	Unkown
HY-114305	A1874	Inhibitor	99.77%	Unkown
HY-123941	FKBP12 PROTAC dTAG-7	Inhibitor	99.47%	Unkown
HY-111433	BRD4 degrader AT1	Inhibitor	98.69%	Unkown
HY-136571	GSK046	Inhibitor	99.70%	Unkown
HY-120028	GNE-207	Inhibitor	99.94%	Unkown
HY-107443	I-BET762 carboxylic acid	Inhibitor	99.55%	Unkown
HY-112609	QCA570	Inhibitor	99.30%	Unkown
HY-114204	GSK8814	Inhibitor	99.80%	Unkown
HY-123844	dBET57	Inhibitor	99.94%	Unkown
HY-110374	NVS-CECR2-1	Inhibitor	99.40%	Unkown
HY-141438	SIM1	Degrader	99.47%	Unkown
HY-160528	IBG3	Inhibitor	98.53%	Unkown
HY-13960	GSK1324726A	Inhibitor	99.92%	Unkown
HY-153385	TMX1	Degrader	99.57%	Unkown
HY-153459	IBG1	Degrader	99.88%	Unkown
HY-125232	MS645		98.0%	Unkown
HY-101146	SF2523	Inhibitor	99.34%	Unkown
HY-138563	GSK973	Inhibitor	99.97%	Unkown
HY-126428	ZL0580	Modulator	99.42%	Unkown
HY-156820	HLDA-221		99.24%	Unkown
HY-133736	PROTAC BRD4 Degrader-5-CO-PEG3-N3		99.73%	Unkown
HY-101519	BETd-260	Inhibitor	99.68%	Unkown
HY-130622	LT052	Inhibitor	98.02%	Unkown
HY-156828	MMH2	Degrader	98.95%	Unkown
HY-163638	BRD4 degrader-1	Degrader	99.85%	Unkown
HY-158031	PLK1/BRD4-IN-5	Inhibitor	98.80%	Unkown
HY-112429	HJB97	Inhibitor	99.12%	Unkown
HY-103633	PROTAC BET Degrader-1	Inhibitor	99.41%	Unkown
HY-129917	KB02-JQ1	Inhibitor	99.10%	Unkown
HY-151594	iBRD4-BD1	Inhibitor	98.77%	Unkown
HY-112376	MZP-54	Inhibitor	98.03%	Unkown
HY-136857	BRD4 degrader-3	Degrader	99.43%	Unkown
HY-114504	RVX-297	Inhibitor	95.00%	Unkown
HY-156827	MMH1	Degrader	99.83%	Unkown
HY-149878	BD-9136	Degrader	98.81%	Unkown
HY-174995	JQ-1-Azidopropylamine	Degrader	99.5700%	Unkown
HY-158764	PROTAC BET Degrader-12	Degrader	98.10%	Unkown
HY-129939	BET-IN-31	Inhibitor	99.85%	Unkown
HY-103632	PROTAC BRD9 Degrader-1	Inhibitor	99.16%	Unkown
HY-148864	JQ1-TCO	Inhibitor	99.95%	Unkown
HY-153894	SRX3177	Inhibitor	99.33%	Unkown
HY-114407	TD-428	Inhibitor	98.81%	Unkown
HY-145125	SJ995973	Degrader	98.88%	Unkown
HY-114416	GS-626510	Inhibitor	99.46%	Unkown
HY-129201	ZEN-2759	Inhibitor	99.51%	Unkown
HY-133131	PROTAC BRD4 Degrader-1	Inhibitor	99.31%	Unkown
HY-111102	FL-411	Inhibitor	99.05%	Unkown
HY-120000	MS402	Inhibitor	98.36%	Unkown
HY-112610	CF53	Inhibitor	99.81%	Unkown
HY-148864A	(Z)-JQ1-TCO	Inhibitor	99.12%	Unkown
HY-161515	BRD4/NAMPT-IN-1	Inhibitor	99.45%	Unkown
HY-136920	CBP/p300-IN-8	Inhibitor	98.03%	Unkown
HY-130256	β-NF-JQ1	Degrader	98.05%	Unkown
HY-133737	GAL-02-221	Inhibitor	99.87%	Unkown
HY-111875	SNIPER(BRD)-1	Degrader	99.68%	Unkown
HY-131061	BET bromodomain inhibitor 1	Inhibitor	99.67%	Unkown
HY-146208	BRD4 Inhibitor-20	Inhibitor	99.24%	Unkown
HY-139148	UMB298	Inhibitor	99.28%	Unkown
HY-115568	BETd-246	Inhibitor	98.34%	Unkown
HY-145264	OARV-771	Inhibitor	98.77%	Unkown
HY-114228	PROTAC BET degrader-2	Inhibitor	98.21%	Unkown
HY-111502	Y06036	Inhibitor	98.57%	Unkown
HY-145260	BRD4/CK2-IN-1	Inhibitor	98.21%	Unkown
HY-123911	dBET23	Inhibitor	95.83%	Unkown
HY-110215	XD14	Inhibitor	95.02%	Unkown
HY-133136	PROTAC BRD4 Degrader-2	Inhibitor	98.30%	Unkown
HY-146999	YM458	Inhibitor	99.16%	Unkown
HY-156774	CCW 28-3	Degrader	99.38%	Unkown
HY-43723	PROTAC BET-binding moiety 2	Ligand	99.77%	Unkown
HY-107442	PROTAC BRD4-binding moiety 1		99.10%	Unkown
HY-168936	DP-15	Degrader	99.06%	Unkown
HY-163729	I-BET787	Inhibitor	99.88%	Unkown
HY-160558	PLK1/BRD4-IN-3	Inhibitor	98.55%	Unkown
HY-138635	PROTAC BRD4 Degrader linker conjugate-3	Inhibitor	98.54%	Unkown
HY-138634	GNE-987 GSH linker-2	Inhibitor	99.48%	Unkown
HY-101121	NI-42	Inhibitor	99.53%	Unkown
HY-103297	OXFBD02	Inhibitor	98.04%	Unkown
HY-107425A	cis-MZ 1		99.8%	Unkown
HY-P10446	TAT-PiET-PROTAC	Inhibitor	98.04%	Unkown
HY-44103	Desmethyl-QCA276	Ligand	99.16%	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown
HY-100696	PNZ5	Inhibitor	99.61%	Unkown
HY-111503	Y06137	Inhibitor	98.39%	Unkown
HY-132991	ML 2-14	Degrader	99.43%	Unkown
HY-142520	I-BET567	Inhibitor	99.49%	Unkown
HY-138632	PROTAC BRD4 Degrader linker conjugate-1	Degrader	98.98%	Unkown
HY-132941	CFT-2718	Degrader	99.87%	Unkown
HY-170380	XY221	Inhibitor	/	Unkown
HY-169358	L134	Inhibitor	99.37%	Unkown
HY-169355	TrimTAC1	Degrader	/	Unkown
HY-161651	BRD4 ligand 6		/	Unkown
HY-107425B	cis-MZ 1 hydrate		99.0%	Unkown
HY-111977	ZEN-3219	Inhibitor	99.75%	Unkown
HY-147046	ET-JQ1-OH	Inhibitor	/	Unkown
HY-111978	ZEN-3862	Inhibitor	98.86%	Unkown
HY-139620	MS83	Degrader	/	Unkown
HY-135236	OXFBD04	Inhibitor	98.99%	Unkown
HY-151594A	iBRD4-BD1 diTFA	Inhibitor	99.52%	Unkown
HY-147202	BRD4 Inhibitor-24	Inhibitor	99.27%	Unkown
HY-132130	BRD4 Inhibitor-13	Inhibitor	99.08%	Unkown
HY-160557	PLK1/BRD4-IN-2	Inhibitor	98.92%	Unkown
HY-130813	BET-IN-6	Inhibitor	/	Unkown
HY-138633	PROTAC BRD4 Degrader linker conjugate-2	Degrader	99.75%	Unkown
HY-146660	BRD4 Inhibitor-18	Inhibitor	/	Unkown
HY-102044	BET-IN-2	Inhibitor	/	Unkown
HY-126325	BY27	Inhibitor	/	Unkown
HY-183273	BRD4/AKT-IN-1	Inhibitor	/	Unkown
HY-186267	BD-7148	Degrader	/	Unkown
HY-175224	PROTAC BRD4 Degrader-36	Degrader	/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-156566	PROTAC BRD4 Degrader-21	Degrader	/	Unkown
HY-153414	GXF-111	Degrader	/	Unkown
HY-163639	BRD4 degrader-2	Inhibitor	/	Unkown
HY-P10445	TAT-PiET	Inhibitor	/	Unkown
HY-149098	SJ1461	Inhibitor	/	Unkown
HY-182912	PLX-4104		/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib	Degrader	/	Unkown
HY-184151	KBD-1	Degrader	/	Unkown
HY-D3393	JQ1-FITC TFA		/	Unkown
HY-130612	PROTAC BRD2/BRD4 degrader-1	Inhibitor	/	Unkown
HY-155371	BT-PROTAC	Degrader	/	Unkown
HY-179734	PROTAC BRD4 Degrader-41	Degrader	/	Unkown
HY-143299	BRD4-BD1-IN-1	Inhibitor	/	Unkown
HY-161093	PROTAC BRD4 Degrader-23	Degrader	/	Unkown
HY-181867	PROTAC BET Degrader-16	Degrader	/	Unkown
HY-111979	ZEN-3411	Inhibitor	/	Unkown
HY-147374	Bromodomain inhibitor-9	Inhibitor	/	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-157290	HL403	Inhibitor	/	Unkown
HY-175225	PROTAC BRD4 Degrader-37	Degrader	/	Unkown
HY-158331	Gal-ARV-771	Degrader	/	Unkown
HY-184339	BRD4-IN-42	Inhibitor	/	Unkown
HY-172124	PROTAC BRD4 Degrader-29	Degrader	/	Unkown
HY-180831	BRD4 D1-IN-3	Inhibitor	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-169081	QS-57	Ligand	/	Unkown
HY-161167	MM-02-08	Degrader	/	Unkown
HY-150683	NC-III-49-1	Inhibitor	/	Unkown
HY-180152	BRD4 ligand 14	Inhibitor	/	Unkown
HY-173327	BRD4 degrader-6	Degrader	/	Unkown
HY-138637	PROTAC BRD4 Degrader-14	Inhibitor	/	Unkown
HY-174920	PROTAC BRD4 Degrader-34	Inhibitor	/	Unkown
HY-150941	BRD4 ligand 2	Inhibitor	/	Unkown
HY-180150	PROTAC BRD4 Degrader-42	Degrader	/	Unkown
HY-181553	PROTAC BRD4 Degrader-44	Degrader	/	Unkown
HY-143327	PROTAC BRD4 Degrader-16	Degrader	/	Unkown
HY-132128	BRD4 Inhibitor-12	Inhibitor	99.34%	Unkown
HY-181758	PROTAC CBP/p300/BRD4 Degrader-1	Degrader	/	Unkown
HY-184727	CDK8/BRD4-IN-1	Inhibitor	/	Unkown
HY-174975	JY-21	Degrader	/	Unkown
HY-179589	JQ-1 (carboxylic acid)-amine-PEG8-cyanogen	Degrader	/	Unkown
HY-183770	LCI40	Inhibitor	/	Unkown
HY-183992	CZL-149	Inhibitor	/	Unkown
HY-181869	PROTAC BET Degrader-17	Degrader	/	Unkown
HY-149806	Bromodomain IN-2	Inhibitor	/	Unkown
HY-179588	PROTAC BET Degrader-14	Degrader	/	Unkown
HY-173564	DW34	Inhibitor	/	Unkown
HY-183339	IL-6/RIPK3-IN-1	Inhibitor	/	Unkown
HY-180957	NEP108	Degrader	/	Unkown
HY-183061	MrTAC-8	Degrader	/	Unkown
HY-153519	WWL0245	Inhibitor	/	Unkown
HY-170686	BRD4 Inhibitor-38	Inhibitor	/	Unkown
HY-153820	PROTAC BRD4 Degrader-20	Degrader	/	Unkown
HY-131203	PROTAC BRD4 Degrader-6	Degrader	/	Unkown
HY-184923	PROTAC BRD4 Degrader-48	Degrader	/	Unkown
HY-181505	BRD4-IN-12	Inhibitor	/	Unkown
HY-182371	BRD4 ligand 15	Ligand	/	Unkown
HY-183077	BRD4 degrader-7	Degrader	/	Unkown
HY-176391	Ad-JQ1	Inhibitor	/	Unkown
HY-180909	TMU454	Degrader	/	Unkown
HY-182801	PROTAC BRD4 Degrader-46	Degrader	/	Unkown
HY-50698A	(S)-BI 2536	Inhibitor	/	Unkown
HY-139294	PROTAC BRD4 Degrader-15	Inhibitor	/	Unkown
HY-135558	PROTAC BRD4 Degrader-3	Degrader	/	Unkown
HY-161769	HL435	Inhibitor	/	Unkown
HY-150684	GXH-II-052	Inhibitor	/	Unkown
HY-183575	JQ1-JX5	Degrader	/	Unkown
HY-160662	BRD4-IN-5	Inhibitor	/	Unkown
HY-180923	AB3145	Degrader	/	Unkown
HY-181496	(S)-JQ-35-Boc	Ligand	/	Unkown
HY-174348	BRD4-IN-10	Inhibitor	/	Unkown
HY-173433	JV8	Degrader	/	Unkown
HY-151972	BRD4 Inhibitor-25	Inhibitor	/	Unkown
HY-143300	BRD4-BD1-IN-2	Inhibitor	/	Unkown
HY-181854	ZX079	Degrader	/	Unkown
HY-174996	NEP162	Degrader	/	Unkown
HY-184874	BRD4 ligand 16	Ligand	/	Unkown
HY-170390	AB3067	Degrader	/	Unkown
HY-W265951	3-Methylcarbostyril	Inhibitor	/	Unkown
HY-147375	Bromodomain inhibitor-10	Inhibitor	/	Unkown
HY-182577	CFT-743	Degrader	/	Unkown
HY-N16067	Penipanoid C	Inhibitor	/	Unkown
HY-175767	PROTAC BRD4 Degrader-39	Degrader	/	Unkown
HY-175240	PROTAC BRD4 Degrader-38	Degrader	/	Unkown
HY-143328	PROTAC BRD4 Degrader-17	Degrader	/	Unkown
HY-143471	WNY0824	Inhibitor	/	Unkown
HY-115541	BRD4-IN-41	Inhibitor	/	Unkown
HY-178510	JQ1-S(GlcNAc)Cq	Degrader	/	Unkown
HY-174811	PROTAC BRD4 Degrader-33	Degrader	/	Unkown
HY-181442	CK2-TN03	Inhibitor	98.02%	Unkown
HY-182958	Hsp70TAC BRD4 Degrader-1	Degrader	/	Unkown
HY-181164	PROTAC BRD4 Degrader-43	Degrader	/	Unkown
HY-161650	PROTAC BRD4 Degrader-26	Degrader	/	Unkown
HY-162875	PROTAC BRD4 Degrader-27	Degrader	/	Unkown
HY-168634	SJ46421	Inhibitor	/	Unkown
HY-181495	RAJQ14	Degrader	/	Unkown
HY-181553A	PROTAC BRD4 Degrader-45	Degrader	/	Unkown
HY-175033	BRD4-IN-11	Inhibitor	/	Unkown
HY-162240	SJH1-51B	Degrader	/	Unkown
HY-184335	PROTAC BET Degrader-18	Degrader	/	Unkown
HY-177730	PROTAC BRD4 Degrader-40	Degrader	/	Unkown
HY-170900	SJ44236	Degrader	/	Unkown
HY-175610	PROTAC FLT3/JAK2/BRD4 Degrader-1	Degrader	/	Unkown
HY-184949	XY-06-005	Inhibitor	/	Unkown
HY-181735	BET-IN-30	Inhibitor	/	Unkown
HY-184455	PROTAC BRD4 Degrader-47	Degrader	/	Unkown
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	Unkown
HY-155680	BET BD2-IN-1	Inhibitor	/	Unkown
HY-174210	PROTAC BRD4 Degrader-31	Degrader	/	Unkown
HY-132942	PROTAC BRD4 ligand-2	Ligand	96.69%	Unkown
HY-174812	BRD4 ligand 8	Inhibitor	/	Unkown
HY-182036	KWZL-7f15	Inhibitor	/	Unkown
HY-125230	CN427	Inhibitor	/	Unkown
HY-169151	PROTAC BRD4-DCAF1 degrader-1		/	Unkown
HY-155393	PROTAC BRD4 Degrader-22	Degrader	/	Unkown
HY-176535	KB-0118	Inhibitor	/	Unkown
HY-181003	GSK785	Inhibitor	/	Unkown
HY-181729	PROTAC BET Degrader-15	Degrader	/	Unkown
HY-162876	PROTAC BRD4 ligand-3	Ligand	/	Unkown
HY-142705	BRD4 D1-IN-2	Inhibitor	/	Unkown
HY-157561	K2-B4-3e	Degrader	/	Unkown
HY-178984	PI3Kα-IN-28	Inhibitor	/	Unkown
HY-153945	BET-IN-15	Inhibitor	/	Unkown
HY-172130	PI3Kδ/BET-IN-1	Inhibitor	/	Unkown
HY-157460	BRD4 Inhibitor-29		/	Unkown
HY-104072	BRD4-IN-3	Inhibitor	/	Unkown
HY-175924	BRD3/BRD4-L ligand-2	Ligand	/	Unkown
HY-175242	PROTAC BRD4 ligand-4	Ligand	/	Unkown
HY-175611	FLT3/JAK2/BRD4 ligand-1	Ligand	/	Unkown
HY-157426	PROTAC BRD4 Degrader-50	Degrader	/	Unkown
HY-169170	PARP1/BRD4-IN-3	Inhibitor	/	Unkown
HY-161368	BRD-SF2	Degrader	/	Unkown
HY-180804	CZL-077	Inhibitor	/	Unkown
HY-173062	BRD4 Inhibitor-40	Inhibitor	/	Unkown
HY-150613	PARP1/BRD4-IN-2	Inhibitor	/	Unkown
HY-181759	CBP/p300/BRD4 ligand-1	Ligand	/	Unkown
HY-143235	BRD4 Inhibitor-15	Inhibitor	/	Unkown
HY-176251	CBP/p300-IN-22	Inhibitor	/	Unkown
HY-W173361	CBP/p300-IN-24	Inhibitor	/	Unkown
HY-185854	PROTAC BRD4 Degrader-49	Degrader	/	Unkown
HY-181831	XQ2		/	Unkown
HY-178094	BRD4 ligand 13	Ligand	/	Unkown
HY-155222	TW9	Inhibitor	/	Unkown
HY-136570A	GSK778 hydrochloride	Inhibitor	/	Unkown
HY-185884	BRD4 ligand 10	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BRD4	VGNC	VGNC:38520
Macaca mulatta	BRD4	VGNC	VGNC:70301
Felis catus	BRD4	VGNC	VGNC:60168
Bos taurus	BRD4	VGNC	VGNC:26559
Rattus norvegicus	BRD4	RGD	RGD:1307282
Mus musculus	BRD4	MGD	MGI:1888520
Others	BRD4	NCBI