2. Gene
  3. BRD4 - bromodomain containing 4 Gene

BRD4 - bromodomain containing 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAP; MCAP; HUNK1; HUNKI

Gene ID: 23476 | Gene type: protein coding

About BRD4

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,235,519-15,332,539 (from NCBI)

This gene has 13 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 111 phenotypes. Ubiquitous expression in placenta (RPKM 10.8), testis (RPKM 9.2) and 25 other tissues.

Summary

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

BRD4 Products(11)

mRNA Protein Name
NM_001379292.1 NP_001366221.1 bromodomain-containing protein 4 isoform short
NM_001330384.2 NP_001317313.1 bromodomain-containing protein 4 isoform 3
XM_047438543.1 XP_047294499.1 bromodomain-containing protein 4 isoform X4
XM_047438541.1 XP_047294497.1 bromodomain-containing protein 4 isoform X2
XM_047438542.1 XP_047294498.1 bromodomain-containing protein 4 isoform X3
XR_007066712.1
NM_001379291.1 NP_001366220.1 bromodomain-containing protein 4 isoform long
XM_047438544.1 XP_047294500.1 bromodomain-containing protein 4 isoform X4
XM_047438540.1 XP_047294496.1 bromodomain-containing protein 4 isoform X1
NM_058243.3 NP_490597.1 bromodomain-containing protein 4 isoform long
NM_014299.3 NP_055114.1 bromodomain-containing protein 4 isoform short

BRD4 Protein Structure

Bromodomain

Bromodomain: Bromodomain (70 - 151)

Bromodomain

Bromodomain: Bromodomain (357 - 445)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1362 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 4

chromosome-associated protein

mitotic chromosome-associated protein

Recombinant BRD4 Proteins

Cat. No. Product Name Accession Purity
HY-P7846 BRD4 Protein, Human (His-Flag) O60885 (E49-E460) ≥95%

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Rhabdomyosarcoma
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Kbg Syndrome

KBGS

Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies

Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies

Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome

Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Cornelia De Lange Syndrome 1

De Lange Syndrome

CDLS1

Cdl

Cdls

Typus Degenerativus Amstelodamensis

Brachmann-De Lange Syndrome

Bdls

Amstelodamensis Typus Degenerativus

Cornelia De Lange Syndrome, Type 1
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Ureteral Obstruction
Heterophyiasis

Heterophyes Infectious Disease
Nasal Cavity Cancer

Nasal Cavity Carcinoma

Malignant Neoplasm Of Nasal Cavities

Malignant Tumor Of The Nasal Cavity

Cancer Of Nasal Cavity

Carcinoma Of Nasal Cavity

Malignant Neoplasm Of Nasal Cavity

Neoplasm Of Nasal Cavity
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-111916 ODM-207 Inhibitor 99.71% Phase 2
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (103)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100972 ARV-771 Inhibitor 99.87% Unkown
HY-101838 dBET1 Inhibitor 99.24% Unkown
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-122826 ZXH-3-26 Inhibitor 98.61% Unkown
HY-14443 XMD8-92 Inhibitor 99.67% Unkown
HY-100482 CPI-637 Inhibitor 99.94% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-123941 FKBP12 PROTAC dTAG-7 Inhibitor 99.88% Unkown
HY-114305 A1874 Inhibitor 99.28% Unkown
HY-101519 BETd-260 Inhibitor 99.59% Unkown
HY-12863 Pelabresib Inhibitor 99.95% Unkown
HY-103632 PROTAC BRD9 Degrader-1 Inhibitor 98.30% Unkown
HY-19999A PF-CBP1 hydrochloride Inhibitor 99.99% Unkown
HY-129937A GNE-987 Inhibitor 99.91% Unkown
HY-123844 dBET57 Inhibitor 99.66% Unkown
HY-141438 SIM1 Inhibitor 99.72% Unkown
HY-125232 MS645 ≥98.0% Unkown
HY-126428 ZL0580 Modulator 99.26% Unkown
HY-120028 GNE-207 Inhibitor 97.02% Unkown
HY-133737 PROTAC BRD4 Degrader-5 Inhibitor 99.93% Unkown
HY-129917 KB02-JQ1 Inhibitor 99.17% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-107443 I-BET762 carboxylic acid Inhibitor 98.64% Unkown
HY-112376 MZP-54 Inhibitor 98.16% Unkown
HY-120000 MS402 Inhibitor 99.62% Unkown
HY-114204 GSK8814 Inhibitor 99.60% Unkown
HY-117491 BRD4 Inhibitor-10 Inhibitor 99.62% Unkown
HY-112429 HJB97 Inhibitor 98.24% Unkown
HY-112609 QCA570 Inhibitor 99.95% Unkown
HY-101146 SF2523 Inhibitor 98.25% Unkown
HY-111102 FL-411 Inhibitor 99.05% Unkown
HY-136920 CBP/p300-IN-8 Inhibitor 99.94% Unkown
HY-111875 SNIPER(BRD)-1 Inhibitor 99.43% Unkown
HY-130622 LT052 Inhibitor 98.77% Unkown
HY-114504 RVX-297 Inhibitor 96.59% Unkown
HY-133131 PROTAC BRD4 Degrader-1 Inhibitor 99.12% Unkown
HY-114416 GS-626510 Inhibitor 99.80% Unkown
HY-107442 PROTAC BRD4-binding moiety 1 / Unkown
HY-111502 Y06036 Inhibitor 98.96% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-148864 JQ1-TCO Inhibitor / Unkown
HY-147202 BRD4 Inhibitor-24 Inhibitor 99.27% Unkown
HY-145264 OARV-771 Inhibitor 98.33% Unkown
HY-142520 I-BET567 Inhibitor 99.49% Unkown
HY-138563 GSK973 Inhibitor 99.46% Unkown
HY-139148 UMB298 Inhibitor 99.11% Unkown
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.00% Unkown
HY-111503 Y06137 Inhibitor 99.90% Unkown
HY-145260 BRD4/CK2-IN-1 Inhibitor 98.62% Unkown
HY-135236 OXFBD04 Inhibitor 98.99% Unkown
HY-107425A cis-MZ 1 Degrader / Unkown
HY-148864A (Z)-JQ1-TCO Inhibitor 99.34% Unkown
HY-111977 ZEN-3219 Inhibitor 99.75% Unkown
HY-133136 PROTAC BRD4 Degrader-2 Inhibitor / Unkown
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / Unkown
HY-129937 (S)-GNE-987 Inhibitor / Unkown
HY-136857 PROTAC BRD4 Degrader-7 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-146660 BRD4 Inhibitor-18 Inhibitor / Unkown
HY-114407 TD-428 Inhibitor / Unkown
HY-102044 BET-IN-2 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-144338 PARP1/BRD4-IN-1 Inhibitor / Unkown
HY-103297 OXFBD02 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-143300 BRD4-BD1-IN-2 Inhibitor / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-157460 BRD4 Inhibitor-29 / Unkown
HY-153519 WWL0245 Inhibitor / Unkown
HY-150613 PARP1/BRD4-IN-2 Inhibitor / Unkown
HY-142705 BRD4 D1-IN-2 Inhibitor / Unkown
HY-151972 BRD4 Inhibitor-25 Inhibitor / Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor / Unkown
HY-143299 BRD4-BD1-IN-1 Inhibitor / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-147375 Bromodomain inhibitor-10 Inhibitor / Unkown
HY-157290 HL403 Inhibitor / Unkown
HY-135558 PROTAC BRD4 Degrader-3 Inhibitor / Unkown
HY-153945 BET-IN-15 Inhibitor / Unkown
HY-161368 BRD-SF2 Degrader / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-146999 YM458 Inhibitor / Unkown
HY-162240 SJH1-51B Degrader / Unkown
HY-111978 ZEN-3862 Inhibitor 98.86% Unkown
HY-160662 BRD4-IN-5 Inhibitor / Unkown
HY-104072 BRD4-IN-3 Inhibitor / Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-139294 PROTAC BRD4 Degrader-15 Inhibitor / Unkown
HY-143328 PROTAC BRD4 Degrader-17 Degrader / Unkown
HY-143235 BRD4 Inhibitor-15 Inhibitor / Unkown
HY-129201 ZEN-2759 Inhibitor 99.45% Unkown
HY-131203 PROTAC BRD4 Degrader-6 Inhibitor / Unkown
HY-149098 SJ1461 Inhibitor / Unkown
HY-147374 Bromodomain inhibitor-9 Inhibitor / Unkown
HY-143471 PLK1/BRD4-IN-1 Inhibitor / Unkown
HY-163413 BRD4-BD1-IN-3 Inhibitor / Unkown
HY-111979 ZEN-3411 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown
HY-160528 IBG3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BRD4 VGNC VGNC:38520
Macaca mulatta BRD4 VGNC VGNC:70301
Felis catus BRD4 VGNC VGNC:60168
Bos taurus BRD4 VGNC VGNC:26559
Rattus norvegicus BRD4 RGD RGD:1307282
Mus musculus BRD4 MGD MGI:1888520
Others BRD4 NCBI