Brd4 - bromodomain containing 4 Gene

Also Known as Brd5; MCAP; HUNK1; WI-11513

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57261

About Brd4

Chromosome 17: 32,415,248-32,503,696 reverse strand.GRCm39:CM001010.3

This gene has 12 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 41 phenotypes. Ubiquitous expression in thymus adult (RPKM 17.8), spleen adult (RPKM 13.4) and 28 other tissues.

Summary

This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]

Brd4 Products (3)

mRNA Protein Name
NM_198094.2 NP_932762.2 bromodomain-containing protein 4 isoform 2
NM_001286630.1 NP_001273559.1 bromodomain-containing protein 4 isoform 3
NM_020508.4 NP_065254.3 bromodomain-containing protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16109376 MGI
enables GTP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
22509028 MGI
enables RNA polymerase II C-terminal domain binding IPI
IPI: Inferred from physical interaction
22509028 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
IDA: Inferred from direct assay
22509028 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
IMP: Inferred from mutant phenotype
22509028 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
23154982 MGI
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
29379197 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16109376 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
16339075 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
11997514 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: Inferred from direct assay
16109376 MGI
involved in positive regulation of T-helper 17 cell lineage commitment IMP
IMP: Inferred from mutant phenotype
28262505 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
22509028 MGI
acts upstream of or within protein phosphorylation IPI
IPI: Inferred from physical interaction
16109376 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
16339075 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
10938129 MGI
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: Inferred from direct assay
23752591 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16109376 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10938129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brd4 Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (57 - 163)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (353 - 454)

BET

BET: pfam17035 (609 - 673)

PHA03247

PHA03247: cl33720 (791 - 1229)

TPH

TPH: cl38442 (1263 - 1306)

BRD4_CDT

BRD4_CDT: pfam17105 (1357 - 1399)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1400 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 4

  • bromodomain-containing 5

  • fsh-like protein

  • mitotic chromosome-associated protein

Brd4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Brd4 Q9ESU6 RELA Homo sapiens Q04206
Pull Down
19103749
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12863 Pelabresib Inhibitor 99.95% Phase 3
HY-111916 ODM-207 Inhibitor 99.58% Phase 2
HY-13030 (+)-JQ-1 Inhibitor 99.91% Phase 1
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
HY-100015 Mivebresib Inhibitor 99.29% Phase 1
HY-117286 (S)-JQ-35 Inhibitor 99.46% Phase 1
HY-117491 BRD4 Inhibitor-10 Inhibitor 99.52% Phase 1

Pre-clinical Phase

Bioactive Molecules (271)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100972 ARV-771 Degrader 99.87% Unkown
HY-101838 dBET1 Inhibitor 99.24% Unkown
HY-78695 JQ-1 carboxylic acid Inhibitor 99.69% Unkown
HY-129937A GNE-987 Inhibitor 99.98% Unkown
HY-136570 GSK778 Inhibitor 99.14% Unkown
HY-122826 ZXH-3-26 Inhibitor 99.53% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-100482 CPI-637 Inhibitor 99.94% Unkown
HY-176521 AR/BRD4 RIPTAC-1 Inhibitor 98.65% Unkown
HY-114305 A1874 Inhibitor 99.77% Unkown
HY-123941 FKBP12 PROTAC dTAG-7 Inhibitor 99.47% Unkown
HY-111433 BRD4 degrader AT1 Inhibitor 98.69% Unkown
HY-136571 GSK046 Inhibitor 99.70% Unkown
HY-120028 GNE-207 Inhibitor 99.94% Unkown
HY-107443 I-BET762 carboxylic acid Inhibitor 99.55% Unkown
HY-112609 QCA570 Inhibitor 99.30% Unkown
HY-114204 GSK8814 Inhibitor 99.80% Unkown
HY-123844 dBET57 Inhibitor 99.94% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-141438 SIM1 Degrader 99.47% Unkown
HY-160528 IBG3 Inhibitor 98.53% Unkown
HY-153385 TMX1 Degrader 99.57% Unkown
HY-13960 GSK1324726A Inhibitor 99.92% Unkown
HY-153459 IBG1 Degrader 99.88% Unkown
HY-125232 MS645 98.0% Unkown
HY-101146 SF2523 Inhibitor 99.34% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-126428 ZL0580 Modulator 99.42% Unkown
HY-156820 HLDA-221 99.24% Unkown
HY-101519 BETd-260 Inhibitor 99.68% Unkown
HY-133736 PROTAC BRD4 Degrader-5-CO-PEG3-N3 99.73% Unkown
HY-130622 LT052 Inhibitor 98.02% Unkown
HY-156828 MMH2 Degrader 98.95% Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor 98.80% Unkown
HY-163638 BRD4 degrader-1 Degrader 99.85% Unkown
HY-112429 HJB97 Inhibitor 99.12% Unkown
HY-103633 PROTAC BET Degrader-1 Inhibitor 99.41% Unkown
HY-129917 KB02-JQ1 Inhibitor 99.10% Unkown
HY-151594 iBRD4-BD1 Inhibitor 98.77% Unkown
HY-136857 BRD4 degrader-3 Degrader 99.43% Unkown
HY-112376 MZP-54 Inhibitor 98.03% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-158764 PROTAC BET Degrader-12 Degrader 98.10% Unkown
HY-156827 MMH1 Degrader 99.83% Unkown
HY-149878 BD-9136 Degrader 98.81% Unkown
HY-174995 JQ-1-Azidopropylamine Degrader 99.5700% Unkown
HY-103632 PROTAC BRD9 Degrader-1 Inhibitor 99.16% Unkown
HY-129939 BET-IN-31 Inhibitor 99.85% Unkown
HY-153894 SRX3177 Inhibitor 99.33% Unkown
HY-114407 TD-428 Inhibitor 98.81% Unkown
HY-148864 JQ1-TCO Inhibitor 99.95% Unkown
HY-145125 SJ995973 Degrader 98.88% Unkown
HY-114416 GS-626510 Inhibitor 99.46% Unkown
HY-129201 ZEN-2759 Inhibitor 99.51% Unkown
HY-133131 PROTAC BRD4 Degrader-1 Inhibitor 99.31% Unkown
HY-111102 FL-411 Inhibitor 99.05% Unkown
HY-120000 MS402 Inhibitor 98.36% Unkown
HY-112610 CF53 Inhibitor 99.81% Unkown
HY-148864A (Z)-JQ1-TCO Inhibitor 99.12% Unkown
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% Unkown
HY-130256 β-NF-JQ1 Degrader 98.05% Unkown
HY-111875 SNIPER(BRD)-1 Degrader 99.68% Unkown
HY-136920 CBP/p300-IN-8 Inhibitor 98.03% Unkown
HY-133737 GAL-02-221 Inhibitor 99.87% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.67% Unkown
HY-139148 UMB298 Inhibitor 99.28% Unkown
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.24% Unkown
HY-114228 PROTAC BET degrader-2 Inhibitor 98.21% Unkown
HY-115568 BETd-246 Inhibitor 98.34% Unkown
HY-145264 OARV-771 Inhibitor 98.77% Unkown
HY-123911 dBET23 Inhibitor 95.83% Unkown
HY-111502 Y06036 Inhibitor 98.57% Unkown
HY-145260 BRD4/CK2-IN-1 Inhibitor 98.21% Unkown
HY-43723 PROTAC BET-binding moiety 2 Ligand 99.77% Unkown
HY-145390 Nrf2 activator-1 Ligand 98.66% Unkown
HY-163729 I-BET787 Inhibitor 99.88% Unkown
HY-133136 PROTAC BRD4 Degrader-2 Inhibitor 98.30% Unkown
HY-107442 PROTAC BRD4-binding moiety 1 99.10% Unkown
HY-168936 DP-15 Degrader 99.06% Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-168546 CFT-1297 Degrader 98.82% Unkown
HY-146999 YM458 Inhibitor 99.16% Unkown
HY-156774 CCW 28-3 Degrader 99.38% Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor 98.55% Unkown
HY-138635 PROTAC BRD4 Degrader linker conjugate-3 Inhibitor 98.54% Unkown
HY-138634 GNE-987 GSH linker-2 Inhibitor 99.48% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-100696 PNZ5 Inhibitor 99.61% Unkown
HY-44103 Desmethyl-QCA276 Ligand 99.16% Unkown
HY-107425A cis-MZ 1 99.8% Unkown
HY-103297 OXFBD02 Inhibitor 98.04% Unkown
HY-P10446 TAT-PiET-PROTAC Inhibitor 98.04% Unkown
HY-149100 PLK1-IN-6 Inhibitor 99.60% Unkown
HY-132991 ML 2-14 Degrader 99.43% Unkown
HY-111503 Y06137 Inhibitor 98.39% Unkown
HY-142520 I-BET567 Inhibitor 99.49% Unkown
HY-138632 PROTAC BRD4 Degrader linker conjugate-1 Degrader 98.98% Unkown
HY-170380 XY221 Inhibitor / Unkown
HY-147202 BRD4 Inhibitor-24 Inhibitor 99.27% Unkown
HY-135236 OXFBD04 Inhibitor 98.99% Unkown
HY-111977 ZEN-3219 Inhibitor 99.75% Unkown
HY-169358 L134 Degrader 99.37% Unkown
HY-132941 CFT-2718 Degrader 99.87% Unkown
HY-151594A iBRD4-BD1 diTFA Inhibitor 99.52% Unkown
HY-169355 TrimTAC1 Degrader / Unkown
HY-107425B cis-MZ 1 hydrate 99.0% Unkown
HY-161651 BRD4 ligand 6 / Unkown
HY-111978 ZEN-3862 Inhibitor 98.86% Unkown
HY-147046 ET-JQ1-OH Inhibitor / Unkown
HY-139620 MS83 Degrader / Unkown
HY-132130 BRD4 Inhibitor-13 Inhibitor 99.08% Unkown
HY-160557 PLK1/BRD4-IN-2 Inhibitor 98.92% Unkown
HY-138633 PROTAC BRD4 Degrader linker conjugate-2 Degrader 99.75% Unkown
HY-130813 BET-IN-6 Inhibitor / Unkown
HY-102044 BET-IN-2 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-146660 BRD4 Inhibitor-18 Inhibitor / Unkown
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / Unkown
HY-184151 KBD-1 Degrader / Unkown
HY-169148 YT117R Degrader / Unkown
HY-157561 K2-B4-3e Degrader / Unkown
HY-132942 PROTAC BRD4 ligand-2 Ligand 96.69% Unkown
HY-187207 BRD4-BD1-IN-4 Inhibitor / Unkown
HY-111979 ZEN-3411 Inhibitor / Unkown
HY-184727 CDK8/BRD4-IN-1 Inhibitor / Unkown
HY-161650 PROTAC BRD4 Degrader-26 Degrader / Unkown
HY-142705 BRD4 D1-IN-2 Inhibitor / Unkown
HY-157290 HL403 Inhibitor / Unkown
HY-187390 BRD4 RIMTAC-1 Degrader / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-173256 Hyp-dBET1 Degrader / Unkown
HY-179588 PROTAC BET Degrader-14 Degrader / Unkown
HY-175610 PROTAC FLT3/JAK2/BRD4 Degrader-1 Degrader / Unkown
HY-184455 PROTAC BRD4 Degrader-47 Degrader / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-174812 BRD4 ligand 8 Inhibitor / Unkown
HY-153519 WWL0245 Inhibitor / Unkown
HY-157426 PROTAC BRD4 Degrader-50 Degrader / Unkown
HY-181735 BET-IN-30 Inhibitor / Unkown
HY-174210 PROTAC BRD4 Degrader-31 Degrader / Unkown
HY-182801 PROTAC BRD4 Degrader-46 Degrader / Unkown
HY-169151 PROTAC BRD4-DCAF1 degrader-1 / Unkown
HY-182036 KWZL-7f15 Inhibitor / Unkown
HY-180957 NEP108 Degrader / Unkown
HY-181505 BRD4-IN-12 Inhibitor / Unkown
HY-181758 PROTAC CBP/p300/BRD4 Degrader-1 Degrader / Unkown
HY-125230 CN427 Inhibitor / Unkown
HY-180150 PROTAC BRD4 Degrader-42 Degrader / Unkown
HY-50698A (S)-BI 2536 Inhibitor / Unkown
HY-182371 BRD4 ligand 15 Ligand / Unkown
HY-183575 JQ1-JX5 Degrader / Unkown
HY-183061 MrTAC-8 Degrader / Unkown
HY-151972 BRD4 Inhibitor-25 Inhibitor / Unkown
HY-181729 PROTAC BET Degrader-15 Degrader / Unkown
HY-153820 PROTAC BRD4 Degrader-20 Degrader / Unkown
HY-147375 Bromodomain inhibitor-10 Inhibitor / Unkown
HY-183273 BRD4/AKT-IN-1 Inhibitor / Unkown
HY-153945 BET-IN-15 Inhibitor / Unkown
HY-184923 PROTAC BRD4 Degrader-48 Degrader / Unkown
HY-183077 BRD4 degrader-7 Degrader / Unkown
HY-157460 BRD4 Inhibitor-29 / Unkown
HY-180923 AB3145 Degrader / Unkown
HY-181003 GSK785 Inhibitor / Unkown
HY-161769 HL435 Inhibitor / Unkown
HY-175611 FLT3/JAK2/BRD4 ligand-1 Ligand / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-181759 CBP/p300/BRD4 ligand-1 Ligand / Unkown
HY-174996 NEP162 Degrader / Unkown
HY-150613 PARP1/BRD4-IN-2 Inhibitor / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-153414 GXF-111 Degrader / Unkown
HY-149098 SJ1461 Inhibitor / Unkown
HY-175240 PROTAC BRD4 Degrader-38 Degrader / Unkown
HY-179734 PROTAC BRD4 Degrader-41 Degrader / Unkown
HY-184949 XY-06-005 Inhibitor / Unkown
HY-174811 PROTAC BRD4 Degrader-33 Degrader / Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-182912 PLX-4104 / Unkown
HY-187372 PROTAC BRD4 Degrader-51 Degrader / Unkown
HY-174920 PROTAC BRD4 Degrader-34 Inhibitor / Unkown
HY-175224 PROTAC BRD4 Degrader-36 Degrader / Unkown
HY-D3393 JQ1-FITC TFA / Unkown
HY-168634 SJ46421 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-155371 BT-PROTAC Degrader / Unkown
HY-161093 PROTAC BRD4 Degrader-23 Degrader / Unkown
HY-180831 BRD4 D1-IN-3 Inhibitor / Unkown
HY-181867 PROTAC BET Degrader-16 Degrader / Unkown
HY-162240 SJH1-51B Degrader / Unkown
HY-184339 BRD4-IN-42 Inhibitor / Unkown
HY-181495 RAJQ14 Degrader / Unkown
HY-172124 PROTAC BRD4 Degrader-29 Degrader / Unkown
HY-175033 BRD4-IN-11 Inhibitor / Unkown
HY-178510 JQ1-S(GlcNAc)Cq Degrader / Unkown
HY-175225 PROTAC BRD4 Degrader-37 Degrader / Unkown
HY-170900 SJ44236 Degrader / Unkown
HY-180152 BRD4 ligand 14 Inhibitor / Unkown
HY-169081 QS-57 Ligand / Unkown
HY-150941 BRD4 ligand 2 Inhibitor / Unkown
HY-143299 BRD4-BD1-IN-1 Inhibitor / Unkown
HY-161167 MM-02-08 Degrader / Unkown
HY-139294 PROTAC BRD4 Degrader-15 Inhibitor / Unkown
HY-181854 ZX079 Degrader / Unkown
HY-181553A PROTAC BRD4 Degrader-45 Degrader / Unkown
HY-138637 PROTAC BRD4 Degrader-14 Inhibitor / Unkown
HY-143327 PROTAC BRD4 Degrader-16 Degrader / Unkown
HY-155393 PROTAC BRD4 Degrader-22 Degrader / Unkown
HY-132128 BRD4 Inhibitor-12 Inhibitor 99.34% Unkown
HY-144338 PARP1/BRD4-IN-1 Inhibitor / Unkown
HY-174975 JY-21 Degrader / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-162876 PROTAC BRD4 ligand-3 Ligand / Unkown
HY-173327 BRD4 degrader-6 Degrader / Unkown
HY-183770 LCI40 Inhibitor / Unkown
HY-183339 IL-6/RIPK3-IN-1 Inhibitor / Unkown
HY-181869 PROTAC BET Degrader-17 Degrader / Unkown
HY-181553 PROTAC BRD4 Degrader-44 Degrader / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-173564 DW34 Inhibitor / Unkown
HY-170686 BRD4 Inhibitor-38 Inhibitor / Unkown
HY-179589 JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Degrader / Unkown
HY-104072 BRD4-IN-3 Inhibitor / Unkown
HY-180804 CZL-077 Inhibitor / Unkown
HY-170390 AB3067 Degrader / Unkown
HY-183992 CZL-149 Inhibitor / Unkown
HY-176535 KB-0118 Inhibitor / Unkown
HY-131203 PROTAC BRD4 Degrader-6 Degrader / Unkown
HY-176251 CBP/p300-IN-22 Inhibitor / Unkown
HY-180909 TMU454 Degrader / Unkown
HY-178984 PI3Kα-IN-28 Inhibitor / Unkown
HY-135558 PROTAC BRD4 Degrader-3 Degrader / Unkown
HY-182958 Hsp70TAC BRD4 Degrader-1 Degrader / Unkown
HY-176391 Ad-JQ1 Inhibitor / Unkown
HY-172130 PI3Kδ/BET-IN-1 Inhibitor / Unkown
HY-175924 BRD3/BRD4-L ligand-2 Ligand / Unkown
HY-160662 BRD4-IN-5 Inhibitor / Unkown
HY-174348 BRD4-IN-10 Inhibitor / Unkown
HY-173433 JV8 Degrader / Unkown
HY-175242 PROTAC BRD4 ligand-4 Ligand / Unkown
HY-143300 BRD4-BD1-IN-2 Inhibitor / Unkown
HY-175767 PROTAC BRD4 Degrader-39 Degrader / Unkown
HY-184335 PROTAC BET Degrader-18 Degrader / Unkown
HY-181496 (S)-JQ-35-Boc Ligand / Unkown
HY-W265951 3-Methylcarbostyril Inhibitor / Unkown
HY-161368 BRD-SF2 Degrader / Unkown
HY-184874 BRD4 ligand 16 Ligand / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-143235 BRD4 Inhibitor-15 Inhibitor / Unkown
HY-182577 CFT-743 Degrader / Unkown
HY-173062 BRD4 Inhibitor-40 Inhibitor / Unkown
HY-N16067 Penipanoid C Inhibitor / Unkown
HY-147374 Bromodomain inhibitor-9 Inhibitor / Unkown
HY-156566 PROTAC BRD4 Degrader-21 Degrader / Unkown
HY-181442 CK2-TN03 Inhibitor 98.02% Unkown
HY-186267 BD-7148 Degrader / Unkown
HY-139996 Pomalidomide-C5-Dovitinib Degrader / Unkown
HY-158331 Gal-ARV-771 Degrader / Unkown
HY-143328 PROTAC BRD4 Degrader-17 Degrader / Unkown
HY-P10445 TAT-PiET Inhibitor / Unkown
HY-163639 BRD4 degrader-2 Inhibitor / Unkown
HY-181164 PROTAC BRD4 Degrader-43 Degrader / Unkown
HY-162875 PROTAC BRD4 Degrader-27 Degrader / Unkown
HY-177730 PROTAC BRD4 Degrader-40 Degrader / Unkown
HY-178094 BRD4 ligand 13 Ligand / Unkown
HY-185854 PROTAC BRD4 Degrader-49 Degrader / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown
HY-155222 TW9 Inhibitor / Unkown
HY-W173361 CBP/p300-IN-24 Inhibitor / Unkown
HY-181831 XQ2 / Unkown
HY-185884 BRD4 ligand 10 Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd4 NCBI NCBI:23476