Th - tyrosine hydroxylase Gene
Also Known as The
Species: Rattus norvegicus
Summary
Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (Tyrosine Hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Th Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_012740.4 | NP_036872.1 | tyrosine 3-monooxygenase |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables amino acid binding |
IDA
IDA: Inferred from direct assay
|
19489646 | RGD |
| enables amino acid binding |
IPI
IPI: Inferred from physical interaction
|
15639226 | RGD |
| enables dopamine binding |
IPI
IPI: Inferred from physical interaction
|
15639226 | RGD |
| enables ferric iron binding |
IDA
IDA: Inferred from direct assay
|
16475826 | RGD |
| enables ferrous iron binding |
IDA
IDA: Inferred from direct assay
|
16475826 | RGD |
| enables monooxygenase activity |
IDA
IDA: Inferred from direct assay
|
33381 | RGD |
| enables oxygen binding |
IDA
IDA: Inferred from direct assay
|
19489646 | RGD |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11943812 | RGD |
| enables protein domain specific binding |
IPI
IPI: Inferred from physical interaction
|
19903816 | RGD |
| enables small molecule binding |
EXP
EXP: Inferred from Experiment
|
19371093 | RGD |
| enables small molecule binding |
IDA
IDA: Inferred from direct assay
|
10375411 | RGD |
| enables tetrahydrobiopterin binding |
IDA
IDA: Inferred from direct assay
|
19489646 | RGD |
| enables tyrosine 3-monooxygenase activity |
IDA
IDA: Inferred from direct assay
|
19489646 | RGD |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in axon |
IDA
IDA: Inferred from direct assay
|
14681933 | RGD |
| located in cytoplasmic vesicle membrane |
IDA
IDA: Inferred from direct assay
|
11943812 | RGD |
| located in dendrite |
IDA
IDA: Inferred from direct assay
|
21362438 | RGD |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
11943812 | RGD |
| located in neuronal cell body |
IDA
IDA: Inferred from direct assay
|
21325515 | RGD |
| located in perikaryon |
IDA
IDA: Inferred from direct assay
|
20434498 | RGD |
| located in synaptic vesicle |
IDA
IDA: Inferred from direct assay
|
15496595 | RGD |
| located in terminal bouton |
IDA
IDA: Inferred from direct assay
|
14681933 | RGD |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tyrosine 3-monooxygenase |
|