CAT - catalase Gene
Species: Homo sapiens
About CAT
This gene has 6 transcripts (splice variants), 240 orthologues and is associated with 2 phenotypes. Broad expression in liver (RPKM 283.8), fat (RPKM 207.7) and 23 other tissues.
Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the Reactive Oxygen Species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
CAT Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001752.4 | NP_001743.1 | catalase |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables NADP binding |
IDA
IDA: Inferred from direct assay
|
10656833 | GOA |
| enables antioxidant activity |
IDA
IDA: Inferred from direct assay
|
10514471 | GOA |
| enables catalase activity |
IDA
IDA: Inferred from direct assay
|
7882369 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
16781659 | GOA |
| enables heme binding |
IDA
IDA: Inferred from direct assay
|
10656833 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
21976670 | GOA |
| enables protein homodimerization activity |
IDA
IDA: Inferred from direct assay
|
10656833 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in UV protection |
IMP
IMP: Inferred from mutant phenotype
|
16644728 | GOA |
| involved in cellular detoxification of hydrogen peroxide |
IDA
IDA: Inferred from direct assay
|
18379038 | GOA |
| involved in hydrogen peroxide catabolic process |
IDA
IDA: Inferred from direct assay
|
18379038 | GOA |
| involved in negative regulation of apoptotic process |
IMP
IMP: Inferred from mutant phenotype
|
16644728 | GOA |
| involved in response to reactive oxygen species |
IMP
IMP: Inferred from mutant phenotype
|
16644728 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of catalase complex |
IPI
IPI: Inferred from physical interaction
|
10656833 | GOA |
| is active in peroxisome |
IDA
IDA: Inferred from direct assay
|
8769411 | GOA |
| located in peroxisome |
IDA
IDA: Inferred from direct assay
|
2895531 | GOA |
| part of protein-containing complex |
IPI
IPI: Inferred from physical interaction
|
21976670 | GOA |
CAT Protein Structure
Catalase: Catalase (28 - 411)
Catalase-rel: Catalase-related immune-responsive (431 - 497)
- 0
- 100
- 200
- 300
- 400
- 500
- 527 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
catalase |
|
CAT Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CAT | P04040 | TYSND1 | Homo sapiens | Q2T9J0 | 29568061 | |
|
Intra
|
CAT | P04040 | TYSND1 | Homo sapiens | Q2T9J0 | 29568061 | |
|
Intra
|
CAT | P04040 | PTPN11 | Homo sapiens | Q06124 | 15556604 | |
|
Intra
|
CAT | P04040 | CAT | Homo sapiens | P04040 | 29568061 | |
|
Intra
|
CAT | P04040 | CAT | Homo sapiens | P04040 | 29568061 | |
|
Intra
|
CAT | P04040 | TYSND1 | Homo sapiens | Q2T9J0 | 22002062 | |
|
Intra
|
CAT | P04040 | PTPN11 | Homo sapiens | Q06124 | 15556604 | |
|
Intra
|
CAT | P04040 | SMARCA4 | Homo sapiens | P51532 | 29568061 | |
|
Intra
|
CAT | P04040 | CAT | Homo sapiens | P04040 | 21988832 | |
|
Intra
|
CAT | P04040 | ACOX1 | Homo sapiens | Q15067 | 29568061 | |
|
Intra
|
CAT | P04040 | ACOX1 | Homo sapiens | Q15067 | 29568061 | |
|
Intra
|
CAT | P04040 | SMARCA4 | Homo sapiens | P51532 | 26496610 | |
|
Intra
|
CAT | P04040 | APP | Homo sapiens | P05067 | 10567208 |
Recombinant CAT Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7744 | Catalase Protein, Human | P04040 (A2-L527) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P7744A | Catalase Protein, Human (His) | P04040 (A2-L527) | ≥ 95%, as determined by reducing SDS-PAGE. |
CAT Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80051 | Catalase Antibody (YA552) | WB, IHC-P | Human, Mouse, Rat |
| HY-P80052 | Catalase Antibody (YA811) | WB, ICC/IF, IHC-P, FC | Human, Mouse, Rat |
| HY-P86618 | Catalase Antibody (YA6310) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Acatalasemia |
|
|
| Pityriasis Versicolor |
|
|
| Acne |
|
|
| Peroxisome Biogenesis Disorder 1b |
|
|
| Neonatal Adrenoleukodystrophy |
|
|
| Diabetic Angiopathy |
|
|
| Chronic Granulomatous Disease |
|
|
| Zellweger Syndrome |
|
|
| Erysipelas |
|
|
| Hemosiderosis |
|
|
| Myeloperoxidase Deficiency |
|
|
| Asbestosis |
|
|
| Peroxisomal Disease |
|
|
| Cryptosporidiosis |
|
|
| Pneumoconiosis |
|
|
| Maple Syrup Urine Disease |
|
|
| Bacteriuria |
|
|
| Asthma |
|
|
| Rhizomelic Chondrodysplasia Punctata |
|
|
| Iron Deficiency Anemia |
|
|
| Syphilis |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Atrophic Gastritis |
|
|
| Refsum Disease, Classic |
|
|
| Rheumatoid Arthritis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Diabetes Mellitus |
|
|
| Male Infertility |
|
|
| Glycogen Storage Disease |
|
|
| Melanoma |
|
|
| Tetralogy Of Fallot |
|
|
| Constipation |
|
|
| Skin Disease |
|
|
| Bacteremia 2 |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Motor Neuron Disease |
|
|
| Cerebral Palsy |
|
|
| Acute Promyelocytic Leukemia |
|
|