CAT - catalase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 847

About CAT

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,438,934-34,472,060 (from NCBI)

This gene has 6 transcripts (splice variants), 240 orthologues and is associated with 2 phenotypes. Broad expression in liver (RPKM 283.8), fat (RPKM 207.7) and 23 other tissues.

Summary

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the Reactive Oxygen Species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

CAT Products (1)

mRNA Protein Name
NM_001752.4 NP_001743.1 catalase
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
10656833 GOA
enables antioxidant activity IDA
IDA: Inferred from direct assay
10514471 GOA
enables catalase activity IDA
IDA: Inferred from direct assay
7882369 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
16781659 GOA
enables heme binding IDA
IDA: Inferred from direct assay
10656833 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21976670 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10656833 GOA
Biological Process GO Annotation Evidence References Source
involved in UV protection IMP
IMP: Inferred from mutant phenotype
16644728 GOA
involved in cellular detoxification of hydrogen peroxide IDA
IDA: Inferred from direct assay
18379038 GOA
involved in hydrogen peroxide catabolic process IDA
IDA: Inferred from direct assay
18379038 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16644728 GOA
involved in response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
16644728 GOA
Cellular Component GO Annotation Evidence References Source
part of catalase complex IPI
IPI: Inferred from physical interaction
10656833 GOA
is active in peroxisome IDA
IDA: Inferred from direct assay
8769411 GOA
located in peroxisome IDA
IDA: Inferred from direct assay
2895531 GOA
part of protein-containing complex IPI
IPI: Inferred from physical interaction
21976670 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAT Protein Structure

Catalase

Catalase: Catalase (28 - 411)

Catalase-rel

Catalase-rel: Catalase-related immune-responsive (431 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 527 a.a.
Protein Preferred Names Protein Names

catalase

  • epididymis secretory sperm binding protein

CAT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAT P04040 TYSND1 Homo sapiens Q2T9J0 29568061
Intra
CAT P04040 TYSND1 Homo sapiens Q2T9J0 29568061
Intra
CAT P04040 PTPN11 Homo sapiens Q06124 15556604
Intra
CAT P04040 CAT Homo sapiens P04040 29568061
Intra
CAT P04040 CAT Homo sapiens P04040 29568061
Intra
CAT P04040 TYSND1 Homo sapiens Q2T9J0 22002062
Intra
CAT P04040 PTPN11 Homo sapiens Q06124 15556604
Intra
CAT P04040 SMARCA4 Homo sapiens P51532 29568061
Intra
CAT P04040 CAT Homo sapiens P04040
Y2H
21988832
Intra
CAT P04040 ACOX1 Homo sapiens Q15067 29568061
Intra
CAT P04040 ACOX1 Homo sapiens Q15067 29568061
Intra
CAT P04040 SMARCA4 Homo sapiens P51532 26496610
Intra
CAT P04040 APP Homo sapiens P05067 10567208
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAT Proteins

Cat. No. Product Name Accession Purity
HY-P7744 Catalase Protein, Human P04040 (A2-L527) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P7744A Catalase Protein, Human (His) P04040 (A2-L527) ≥ 95%, as determined by reducing SDS-PAGE.

CAT Antibodies

Cat. No. Product Name Application Reactivity
HY-P80051 Catalase Antibody (YA552) WB, IHC-P Human, Mouse, Rat
HY-P80052 Catalase Antibody (YA811) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat
HY-P86618 Catalase Antibody (YA6310) WB, IHC-P, ICC/IF, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Acatalasemia
  • Acatalasia

  • Catalase Deficiency

  • Deficiency Of Catalase

  • ACATLAS

  • Takahara'S Disease

  • Takahara Disease

Pityriasis Versicolor
  • Tinea Versicolor

  • Infection By Pityrosporum Furfur

Acne
  • Acne Vulgaris

  • Acne Varioliformis

  • Frontalis Acne

Peroxisome Biogenesis Disorder 1b
  • Peroxisome Biogenesis Disorder

  • Infantile Refsum Disease

  • Infantile Phytanic Acid Storage Disease

  • PBD1B

  • Refsum Disease, Infantile

  • Adrenoleukodystrophy, Autosomal Neonatal

  • Ird

  • Mild Pbd-Zsd

  • Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Pbd-Zsd

  • Peroxisome Biogenesis Disorder Spectrum

  • Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Autosomal Neonatal Adrenoleukodystrophy

  • Refsum Disease Infantile

  • Peroxisome Biogenesis Disorders

  • Peroxisome Biogenesis Disorder, Type 1b

Neonatal Adrenoleukodystrophy
  • Nald

  • Adrenoleukodystrophy Autosomal Neonatal Form

  • Intermediate Pbd-Zsd

  • Intermediate Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Adrenoleukodystrophy, Autosomal, Neonatal Form

  • Adrenoleukodystrophy Neonatal

  • Adrenoleukodystrophy, Neonatal

Diabetic Angiopathy
  • Diabetic Angiopathies

  • Diabetic Peripheral Angiopathy

  • Diabetic Vascular Disorder

Chronic Granulomatous Disease
  • Cgd

  • Granulomatous Disease, Chronic

  • Autosomal Recessive Chronic Granulomatous Disease

  • X-Linked Chronic Granulomatous Disease

  • Bridges-Good Syndrome

  • Congenital Dysphagocytosis

  • Quie Syndrome

  • Chronic Septic Granulomatosis

  • Chronic Granulomatous Disorder

  • Granulomatous Disease Chronic

  • Granulomatous Disease, Chronic, X-Linked

Zellweger Syndrome
  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Erysipelas
Hemosiderosis
  • Haemosiderosis

  • Iron Overload

Myeloperoxidase Deficiency
  • Mpo Deficiency

  • MPOD

Asbestosis
  • Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

  • Pulmonary Fibrosis - From Asbestos Exposure

Peroxisomal Disease
  • Peroxisomal Disorder

  • Peroxisomal Disorders

  • Peroxisomal Defects

Cryptosporidiosis
  • Cryptosporidial Gastroenteritis

  • Intestinal Cryptosporidiosis

  • Infection By Cryptosporidium

  • Gastroenteritis Due To Cryptosporidium

  • Cryptosporidial Infection

Pneumoconiosis
  • Pneumoconioses

  • Silicosis Nos

  • Complicated Silicosis

  • Fibrosis Of Lung With Silicosis

  • Nodular Silicosis

  • Pneumoconiosis Due To Silica

  • Silicotic Fibrosis Of Lung

  • Simple Silicosis

  • Silicatosis

  • Silicotic Lung Fibrosis

  • Pneumoconiosis Due To Talc

  • Pulmonary Talcosis

  • Talc Lung Disease

  • Talc Pneumoconiosis

  • Talc Workers' Pneumoconiosis

  • Talcosis

  • Fibrosis Of Lung Due To Talc

  • Asbestos Pneumoconiosis

  • Amianthosis

  • Asbestosis

  • Lung Fibrosis With Asbestosis

  • Pulmonary Asbestosis

Maple Syrup Urine Disease
  • MSUD

  • Bckd Deficiency

  • Branched-Chain Ketoaciduria

  • Branched-Chain Alpha-Keto Acid Dehydrogenase Deficiency

  • Keto Acid Decarboxylase Deficiency

  • Maple Syrup Urine Disease, Type Ii

  • Branched Chain Ketoaciduria

  • Classic Maple Syrup Urine Disease

  • Intermittent Maple Syrup Urine Disease

  • Maple Syrup Urine Disease, Type Ia

  • Ketoacidaemia

  • Bckdh Deficiency

  • Branched-Chain 2-Ketoacid Dehydrogenase Deficiency

  • Thiamine-Responsive Maple Syrup Urine Disease

  • Intermediate Maple Syrup Urine Disease

  • Maple Syrup Urine Disease Type 1a

  • Maple Syrup Urine Disease Type 1b

  • Maple Syrup Urine Disease Type 2

  • Maple Syrup Urine Disease, Type Ib

  • Dihydrolipoamide Dehydrogenase Deficiency

  • Branched-Chain Ketoacid Dehydrogenase Deficiency

  • Maple Syrup Disease

  • Ketoacidemia

  • Classic Bckd Deficiency

  • Classic Msud

  • Classic Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Classic Branched-Chain Ketoaciduria

  • Thiamine-Responsive Bckd Deficiency

  • Thiamine-Responsive Msud

  • Thiamine-Responsive Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Intermittent Bckd Deficiency

  • Intermittent Msud

  • Intermittent Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Maple Syrup Urine Disease 1a

  • MSUD1A

  • Maple Syrup Urine Disease Type Ia

  • Msud Type Ia

  • Maple Syrup Urine Disease 1b

  • MSUD1B

  • Maple Syrup Urine Disease Type Ib

  • Msud Type Ib

  • Maple Syrup Urine Disease 2

  • MSUD2

  • Maple Syrup Urine Disease Type Ii

  • Msud Type Ii

  • Nadh Cytochrome B5 Reductase Deficiency

  • Lactic Acidosis, Congenital Infantile, Due To Lad Deficiency

  • Ketonemia

  • Maple Syrup Urine Disease, Type 1b

  • Ketoacid Decarboxylase Deficiency

  • Oxoacid Decarboxylase Deficiency

  • Branched Chain Ketoacid Dehydrogenase Deficiency

  • Msud - [Maple-Syrup-Urine Disease]

  • Ketoaminoacidaemia

  • Bckd - [Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency]

  • Maple-Syrup-Urine Disorder

  • Maple-Syrup-Urine Syndrome

Bacteriuria
Asthma
  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus

Rhizomelic Chondrodysplasia Punctata
  • Chondrodysplasia Punctata, Rhizomelic

  • Rcdp

  • Chondrodysplasia Punctata, Rhizomelic Form

  • Rcp

  • Chondrodysplasia Punctata Rhizomelic

Iron Deficiency Anemia
  • Iron-Deficiency Anemia

  • Fe Deficiency Anaemia

  • Ida - [Iron Deficiency Anemia]

  • Fe - [Iron] Deficiency Anemia Nos

Syphilis
  • Chancre

  • Syphilitic Chancre

Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1
  • Vitiligo

  • VAMAS1

  • Slev1

  • Vtlg

  • Systemic Lupus Erythematosus, Vitiligo-Related

  • Vitiligo-Associated Multiple Autoimmune Disease 1

  • Systemic Lupus Erythematosus Vitiligo-Related

Atrophic Gastritis
  • Gastritis, Atrophic

  • Gastric Atrophy

  • Gastritis Atrophic

Refsum Disease, Classic
  • Refsum Disease

  • Heredopathia Atactica Polyneuritiformis

  • Phytanic Acid Oxidase Deficiency

  • Hmsn Iv

  • Refsum Disease, Adult, 1

  • Refsum'S Disease

  • Phytanic Acid Storage Disease

  • Hereditary Motor And Sensory Neuropathy Iv

  • Hmsn4

  • Hmsn Type Iv

  • Hmsn 4

  • Adult Refsum Disease

  • Classic Refsum Disease

  • Hereditary Motor And Sensory Neuropathy Type Iv

  • Refsum Syndrome

  • Hsmn Iv

  • Disorder Of Cornification 11

  • Doc 11

  • Hereditary Sensory And Motor Neuropathy Type 4

  • Hypertrophic Neuropathy Of Refsum

  • Ard

  • Crd

  • Hereditary Motor And Sensory Neuropathy Type 4

  • Phytanic-Coa Hydroxylase Deficiency

  • RD

Rheumatoid Arthritis
  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis

Systemic Lupus Erythematosus
  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]

Diabetes Mellitus
  • Diabetes

Male Infertility
  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility

Glycogen Storage Disease
  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency

Melanoma
  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas

Tetralogy Of Fallot
  • TOF

  • Fallot Tetralogy

  • Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

  • Tetrad Of Fallot

  • Fallot Tetrad

  • Fallot Disease

  • Fallot Complex

  • Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

  • Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

  • Interventricular Septal Defect, In Tetralogy Of Fallot

  • Ventricular Septal Defect With Obstructed Right Ventricular Outflow

  • Tof - [Tetralogy Of Fallot]

  • Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

  • Pulmonary Atresia, Ventricular Septal Defect And Mapcas

  • Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Constipation
Skin Disease
  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders

Bacteremia 2
  • Bacteremia

  • Bacteremia, Susceptibility To, 2

  • BACTS2

  • Bacteremia, Susceptibility To

  • Bacteremia, Susceptibility To, Type 2

Type 2 Diabetes Mellitus
  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes

Motor Neuron Disease
  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease

Cerebral Palsy
  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed

Acute Promyelocytic Leukemia
  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma