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Epigenetic regulation mediates the three-dimensional genome and cellular memory

Multiprotein Complexes and Disease DNA Metabolism And Repair Cellular Stress Cellular Degeneration

The three-dimensional genome describes the non-random folding of chromosomes inside the nucleus, whereas cellular memory denotes the persistence of a regulatory state after the initiating signal has disappeared or through cell division. These concepts converge because chromosome folding constrains which promoters, enhancers, silencers, and nuclear compartments can communicate. Chromosome conformation studies established a hierarchy of active and inactive compartments, topologically associating domains, loops, and local contacts that organize gene regulation across genomic distance. Epigenetic marks and chromatin-bound proteins help stabilize these structures, while nuclear architecture feeds back on transcription and cell identity. This reciprocal relationship is important in development, differentiation, aging, and cancer, where an altered spatial contact can sustain an inappropriate expression program without changing DNA sequence[1][2].

At the mechanistic level, CTCF and cohesin establish many loop boundaries and insulated neighborhoods, compartmentalization separates active from inactive chromatin, and contacts between enhancers and promoters increase regulatory opportunity without making physical proximity alone sufficient for transcription. Polycomb-associated domains, heterochromatin, and lamina interactions add repressive layers, whereas active chromatin preferentially occupies transcriptionally permissive nuclear environments. DNA methylation can influence occupancy of methylation-sensitive factors such as CTCF, and histone modifications recruit readers and remodeling complexes that change chromatin mobility or compaction. During differentiation, these components are reorganized together, allowing transient developmental signals to become embedded in both local chromatin state and long-range genome topology[1][2].

Cellular memory additionally requires persistence through molecular turnover and, in dividing cells, DNA replication. Single-cell experiments showed that epigenetic repression can display distinct establishment, memory, and reactivation kinetics depending on the recruited regulator, demonstrating that a chromatin mark is not equivalent to a fixed state. Replication studies found different segregation behavior for parental nucleosomes in active and repressed domains, providing a physical route by which chromatin information can be transferred while new nucleosomes are deposited. These findings support models in which feedback among histone marks, reader-writer enzymes, transcription factors, and 3D contacts reconstructs a regulatory domain after replication. Applications include mapping developmental commitment, explaining stable disease cell states, engineering synthetic transcriptional memory, and identifying structural vulnerabilities created by oncogenic enhancer rewiring[3][4].

The major unresolved question is causality. A contact may create regulation, result from regulation, or simply correlate with a shared chromatin environment, and population-averaged conformation maps conceal cell-to-cell variability. It also remains unclear which architectural features survive mitosis directly and which are rebuilt from bookmarks, local chromatin marks, or transcription-factor networks. Future work should combine live-cell imaging, perturbative loop engineering, single-cell multi-omics, and lineage tracing across replication and differentiation. Disease studies need matched genetic, epigenetic, transcriptional, and structural measurements because mutations in cohesin, CTCF sites, lamins, or chromatin regulators can converge on similar spatial phenotypes. Therapeutically, the most defensible targets will be proteins whose perturbation reverses a pathogenic memory state without broadly disrupting essential genome organization A useful benchmark should test whether disrupting one loop or boundary erases the remembered expression state and whether restoring the contact rescues it. Measurements across several cell cycles can then separate transient architectural perturbation from genuine inheritance[1][2][3][4].

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Cat. No. Product Name Information Application Publication
HY-K0202 Protein A/G Magnetic Beads

MCE Protein A/G Magnetic Beads provide a fast and convenient method for Immunoprecipitation, Co-Immunoprecipitation and Chromatin Immunoprecipitation. The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Purification Magnetic Beads

1442
HY-N0005 Curcumin
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
Histone Acetyltransferase   Epigenetic Reader Domain   Keap1-Nrf2   Autophagy   Mitophagy   Influenza Virus   Ferroptosis   Apoptosis  
Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Pain   Digestive System Inflammation   Glucose Metabolism   Metastatic Breast Cancer   SARS-CoV-2 Infection   Obesity   Lung Fibrosis  
139
HY-L009 Kinase Inhibitor Library
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. Kinase inhibitor library designed by MCE contains 3,998 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Signaling Pathway Targeting Libraries

125
HY-13470 GSK126
GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM.
Histone Methyltransferase  
Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Small Cell Lung Cancer  
105
HY-L027 Antiviral Compound Library
Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs. MCE designs a unique collection of 1,237 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.

Disease Focused Libraries

104
HY-L005 Epigenetics Compound Library
Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases. MCE provide a unique collection of 2,031 epigenetics-related compounds that can be used in the research of the related diseases.

Signaling Pathway Targeting Libraries

102
HY-13803 Tazemetostat
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
Histone Methyltransferase   Apoptosis  
Pancreatic Cancer   Digestive System Inflammation   Castration-Resistant Prostate Cancer   Metastatic Prostate Cancer   Acute Myeloid Leukemia  
98
HY-L004 Cell Cycle/DNA Damage Compound Library
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair. MCE owns a unique collection of 3,522 cell cycle/DNA damage-related compounds which can be used in the research of the same.

Signaling Pathway Targeting Libraries

93
HY-L006 GPCR/G Protein Compound Library
GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery. MCE provides a unique collection of 3,519 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

Signaling Pathway Targeting Libraries

93
HY-L030 Human Endogenous Metabolite Compound Library
The composition of endogenous metabolite compounds is affected by the upstream influence of the proteome and genome as well as environmental factors, lifestyle factors, medication, and underlying disease. Therefore, metabolites have been described as proximal reporters of disease because their abundances in biological specimens are often directly related to pathogenic mechanisms. In more recent years, metabolomics approach has been adopted or suggested to be used in various research areas including drug discovery, neurosciences, agriculture, food and nutrition, and environmental sciences. MCE owns a unique collection of 765 human endogenous metabolites, all of which are derived from human issues. This library is a powerful tool for metabonomics research and metabolism-related drug discovery.

Metabolism Focused Libraries

91
HY-L024 Histone Modification Research Compound Library
A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases. MCE owns a unique collection of 931 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Signaling Pathway Targeting Libraries

85
HY-L091 Lipid Metabolism Compound Library
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 1,026 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Signaling Pathway Targeting Libraries

85
HY-L092 Glucose Metabolism Compound Library
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 1,777 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Signaling Pathway Targeting Libraries

85
HY-L040 Anti-diabetic Compound Library
Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage. The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes. MCE Anti-diabetic Compound Library owns a unique collection of 1,172 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Disease Focused Libraries

84
HY-L149 Membrane Protein-targeted Compound Library
A membrane protein is a protein molecule that is attached to or associated with the membrane of a cell or an organelle. Membrane proteins can be classified into two groups based on how the protein is associated with the membrane: integral membrane proteins and peripheral membrane proteins. In humans, about 30% genome encodes membrane proteins. Membrane proteins perform a variety of functions vital to the survival of organisms, for example, signal transduction, molecules or ion transportation, enzymatic catalysis, and intercellular communication. Membrane proteins also play important roles in drug discovery. As reported, more than 60% of current drug targets are membrane proteins. MCE supplies a unique collection of 7,999 compounds targeting a variety of membrane proteins. MCE Membrane Protein-targeted Compound Library can be used for membrane protein-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

84
HY-L005M Epigenetics Compound Library Mini
Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer. MCE provide a unique collection of 295 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.

Signaling Pathway Targeting Libraries

83
HY-L087 Anti-Obesity Compound Library
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 3,741 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Disease Focused Libraries

83
HY-L125 Anti-Pulmonary Fibrosis Compound Library
Pulmonary fibrosis (PF), also known as diffuse interstitial pulmonary fibrosis, is a very common end-stage manifestation of several diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension, and scleroderma, characterised by excessive matrix deposition and destruction of the lung architecture, finally leading to respiratory insufficiency. PF has become a global disease with significantly increased incidence rate, and the most common form of pulmonary fibrosis is idiopathic pulmonary fibrosis (IPF). Lung fibrosis is a complex disease, a multitude of signal factors and signaling pathways is disrupted in this complex disease, such as TGF-β, Wnt, VEGF and PI3K–Akt. MCE offers a unique collection of 2,810 compounds with identified and potential anti-pulmonary fibrosis activity. MCE Anti-Pulmonary Fibrosis Compound Library is a useful tool for anti-pulmonary fibrosis drugs screening and other related research.

Disease Focused Libraries

83
HY-L230 FDA Kinase Inhibitor Library
Kinases are enzymes that catalyze the addition of phosphate groups to substrate molecules, a process known as phosphorylation. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes, including cell division, metabolism, and signal transduction. The human genome encodes over 500 kinases, which collectively regulate approximately 50% of cellular functions. Due to their pivotal roles, kinases represent one of the most important target classes in drug development. Kinase inhibitors can selectively block the activity of disease-associated kinases, making them valuable therapeutics for conditions such as cancer and inflammatory diseases. FDA-approved kinase inhibitors have undergone extensive preclinical and clinical studies, demonstrating high bioactivity, favorable safety profiles, and good bioavailability, rendering them suitable for investigating new therapeutic indications.
83
HY-L244 High-Efficiency Gene Editing Compound Library
In this era of rapid advancement in gene-editing technology, the CRISPR-Cas system, with its powerful programmability, is leading a transformation in life sciences research. It enables efficient and precise targeted modification of an organism's genome, providing a robust tool for studying gene function, treating genetic diseases, and improving crop varieties. However, bottlenecks such as insufficient editing efficiency, low homologous directed repair efficiency, and potential off-target risks remain major challenges in achieving precise genetic modifications and developing gene therapies. To overcome these limitations, the MCE High-Efficiency Gene Editing Compound Library systematically includes 761 small molecules that are known or have the potential to enhance gene-editing efficiency. These compounds work by targeting and modulating the DNA damage repair network, mechanistically inhibiting non-homologous end joining, promoting homologous directed repair, or regulating chromatin states and cellular responses, thereby significantly optimizing editing outcomes. This library is suitable for developing "CRISPR-small molecule" combination therapy strategies, improving gene-editing efficiency, and providing a powerful tool for in-depth research into the mechanisms of DNA damage repair in gene editing.

Signaling Pathway Targeting Libraries

83
HY-L248 RNA Binding Bioactive Compound Library
The RNA-targeted bioactive compound library is a high-quality collection of small molecules specifically designed and curated to target RNA structures and functions. It is widely applied in cutting-edge drug discovery and life science research. Unlike traditional strategies that focus on protein targets, RNA-targeted compounds can directly modulate various functional RNA molecules by influencing their splicing, translation, stability, or structural conformation, thereby enabling precise intervention in key biological processes. In the field of drug development, these compounds provide a novel approach to addressing previously “undruggable” targets and have demonstrated significant potential in areas such as oncology, antiviral therapies, and neurodegenerative diseases. For example, by targeting disease-associated RNA structural domains or regulating the aberrant expression of non-coding RNAs, these compounds can effectively inhibit disease progression or restore normal cellular function. In mechanistic studies, RNA-targeted compounds serve as valuable chemical biology tools to elucidate the roles of RNA in gene expression regulation, cellular signaling pathways, and disease development. The MCE RNA-targeted bioactive compound library contains 858 compounds, sourced from databases such as TargetRX Atlas and R-BIND. The library features excellent structural diversity and biological activity, making it suitable for high-throughput screening (HTS), target validation, phenotypic screening, and lead compound discovery. It represents a valuable resource for RNA-related research and innovative drug development.

Signaling Pathway Targeting Libraries

83
HY-L914 Serine/Threonine Focused Covalent Fragment Library
In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

Functional Fragment Libraries

83
HY-L932V Kinase Macrocyclic Compound Virtual Library
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.
83
HY-L932V0 Kinase Macrocyclic Compound Virtual Library
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.

AI-enabled Libraries

83
HY-L943 MCE‑18 Novelty drug‑like Library
MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets. This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.

Distinctive Diversity Libraries

83
HY-D0842 BSA Protein
BSA Protein (Bovine Serum Albumin; BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
66
HY-K0204 Protein G Magnetic Beads

Protein G Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Purification Magnetic Beads

66
HY-W250163 NAD+ lithium
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
52
HY-10442 3-Deazaneplanocin A
3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor. 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity.
Histone Methyltransferase   S-adenosylhomocysteine hydrolase (SAHH)   Orthopoxvirus  
Respiratory Disease   Leukemia/Lymphoma/Myeloma   Non-Small Cell Lung Cancer   Orthopoxvirus Infection  
37
HY-101563 Pemrametostat
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma.
Histone Methyltransferase   SARS-CoV   MDM-2/p53   CDK   Apoptosis  
Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   HER-2 Positive Breast Cancer   SARS-CoV-2 Infection  
34
HY-13500 GSK343
GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
Histone Methyltransferase   Autophagy  
Leukemia/Lymphoma/Myeloma  
33
HY-15593 Pinometostat
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.
Histone Methyltransferase  
Leukemia/Lymphoma/Myeloma   SARS-CoV-2 Infection  
33
HY-K0203 Protein A Magnetic Beads

Protein A Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Purification Magnetic Beads

32
HY-B0350A Sodium butyrate
Sodium butyrate ((Butanoic acid; Butyric acid) sodium) is an orally active HDAC inhibitor. Sodium butyrate induces hyperacetylation of core histones and affects phosphorylation of H1/H2A, thereby altering chromatin structure and regulating gene expression. Sodium butyrate can be used in research related to various cancers, inflammatory bowel disease, and sickle cell anemia.
HDAC  
Cancer   Digestive System Disease   Digestive System Inflammation   Blood Disease  
28
HY-10587 BIX-01294
BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.
Histone Methyltransferase   Autophagy  
Leukemia/Lymphoma/Myeloma  
27
HY-D0085 DiSC3(5)
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3(5) in the presence of Na+/K+-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells.
Fluorescent Dye  
Cancer  
21
HY-K0205 Protein L Magnetic Beads

Protein L Magnetic Beads provide a fast and convenient method for Immunuoprecipitaion, Co-Immunoprecipitation and Chromatin Immunoprecipitation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Purification Magnetic Beads

20
HY-B2233A Calcium phosphorylcholine chloride, 98%
Calcium phosphorylcholine chloride, 98% is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride, 98% exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride, 98% exhibits a surprising range of immunomodulatory properties.
Biochemical Assay Reagents   Adrenergic Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
13
HY-136328 EZM0414 TFA
EZM0414 (SETD2-IN-1) TFA is the TFA salt form of EZM0414 (HY-144858). EZM0414 TFA is a potent, selective, orally active inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 TFA can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
Histone Methyltransferase  
10
HY-B1718 Choline theophyllinate
Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.
Histamine Receptor  
Respiratory Disease   Sleep-Wake Disorder   Cardiovascular Disease   Urologic Disease  
6
HY-101036 Choline (bitartrate)
Choline bitartrate (Oxtriphylline) is an orally active methylxanthine-derived choline salt of theophylline. Choline bitartrate exhibits weak antihistaminic and anticholinergic activities and can enhance the effects of histamine and acetylcholine. Choline bitartrate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates central nervous system motor activity, and induces transient hypotension following a pressor phase. Choline bitartrate modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline bitartrate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.

Source: human milk

Histamine Receptor  
Respiratory Disease   Sleep-Wake Disorder   Cardiovascular Disease   Urologic Disease  
6
HY-102055 JAK2 JH2 Tracer
JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd value of 0.2 μM.
JAK  
6
HY-B1337 Choline chloride
Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.
Histamine Receptor  
Respiratory Disease   Sleep-Wake Disorder   Cardiovascular Disease   Urologic Disease  
6
HY-109108 Valemetostat
Valemetostat (DS-3201), a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat can be used for the research of relapsed/refractory peripheral T-cell lymphoma.
Histone Methyltransferase  
Prostate Cancer   Leukemia/Lymphoma/Myeloma  
5
HY-15435A CHAPS hydrate
CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins.
Biochemical Assay Reagents   Exosomes  
4
HY-139611 Navlimetostat
Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study.
Histone Methyltransferase  
4
HY-P1454A Fz7-21 TFA
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids.
Wnt  
Cancer  
3
HY-P1454 Fz7-21
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids.
Wnt  
Cancer  
3
HY-W012078 5-Methyl-2'-deoxycytidine
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells.
DNA Methyltransferase   Endogenous Metabolite  
Leukemia/Lymphoma/Myeloma  
3
HY-W015346 Desaminotyrosine
Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

Source: Saccharomyces cerevisiae

Influenza Virus   Endogenous Metabolite  
Viral Infection  
3
HY-W012078R 5-Methyl-2'-deoxycytidine (Standard)
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells.
Reference Standards   DNA Methyltransferase   Endogenous Metabolite  
2
HY-B1514 Allantoic acid
Allantoic acid is a degradative product of uric acid and associated with purine metabolism.
Endogenous Metabolite  
2
HY-D0944 Giemsa stain
Giemsa stain is a composite dye composed of methylene azure, methylene blue, eosin and other components. Giemsa stain stains chromatin, nuclear membranes, specific cytoplasmic components and microorganisms. Giemsa stain is used in research on cytological and parasitological staining.
Fluorescent Dye  
2
HY-N0620 Mulberroside C
Mulberroside C is one of the main bioactive components in white mulberry (Morus alba L.). Mulberroside C exhibits antiplatelet, antiviral and neutrophil-regulating activities, and binds to EV-A71 VP1 with a Kd value of 1.289 nM. Mulberroside C reduces the phosphorylation level of ERK, promotes the phosphorylation of IP3RI at the Ser1756 site, and decreases calcium influx and calcium mobilization. Mulberroside C inhibits the expression of P-selectin (P-selectin). Mulberroside C upregulates the cyclic nucleotide signaling pathway in human platelets. Mulberroside C binds to IL-23R, upregulates the expression of G-CSF, GM-CSF and RASGRP1, and activates the RAS/ERK signaling pathway. Mulberroside C promotes neutrophil maturation, accelerates the recovery of leukopenia, and enhances the antibacterial activity of neutrophils. Mulberroside C inhibits the replication of hepatitis C virus in replicon cells. Mulberroside C prevents the uncoating and genome release of EV-A71, and inhibits the synthesis of viral proteins and RNA. Mulberroside C can be used in studies related to thrombosis-mediated cardiovascular diseases, chemotherapy- and radiotherapy-induced leukopenia, hepatitis C virus infection, and hand, foot and mouth disease.
HCV   Enterovirus   PERK   Calcium Channel   P-selectin   HCN Channel   Ras   ERK   DNA/RNA Synthesis  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Hepatitis C Virus Infection   Staphylococcus Aureus Infection  
1
HY-155539 Cisd2 agonist 2
Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters.
IKZF Family   Zinc Finger Protein  
Digestive System Disease   Digestive System Inflammation  
1
HY-113408 Tiglyl carnitine
Tiglyl carnitine is found to be associated with celiac disease and mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-D1815 Allophycocyanin
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I.
Fluorescent Dye  
1
HY-N5139 Lecithins, egg
Lecithins, egg (Lecithins, egg yolk; Belovo PL 85) is an orally active natural phospholipid mixture extracted from egg yolks. Lecithins, egg inhibits the activities of acetylcholinesterase (AChE) and angiotensin-converting enzyme (ACE). Lecithins, egg exhibits antibacterial, antioxidant and anti-inflammatory activities, and helps delay cellular senescence. Lecithins, egg enhances nerve conduction, improves memory and cognitive function, and exerts positive effects on delaying neurodegenerative diseases. Lecithins, egg promotes lipid absorption and alleviates diarrhea. Lecithins, egg acts as a high-efficiency drug carrier for the preparation of targeted drug delivery systems such as liposomes.
Cholinesterase (ChE)   Angiotensin-converting Enzyme (ACE)   Bacterial  
Digestive System Disease   Bacterial Infection   Neurodegenerative Disease   Oxidative Stress and Inflammation   Lipid Metabolism  
1
HY-153368 Zomiradomide
Zomiradomide (KT-413) is an orally active IRAK4 PROTAC degrader with a DC50 of 6 nM. Zomiradomide inhibits the NF-κB signaling pathway, while its molecular glue function mediates the degradation of Ikaros and Aiolos (with a DC50 of 1 nM for both), activates the IFN-I signaling pathway, and selectively degrades IMiD substrates. Zomiradomide inhibits cancer cell proliferation and tumor growth. Zomiradomide can be used in research related to B-cell non-Hodgkin's lymphoma and diffuse large B-cell lymphoma.
PROTACs   IRAK   NF-κB   IFNAR   Zinc Finger Protein   Molecular Glues  
Non-Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
1
HY-113162 Bovinic acid
Bovinic acid is an orally active anti-inflammatory agent. Bovinic acid inhibits oxidative stress and ferroptosis by regulating the Keap1-Nrf2 signaling pathway. Bovinic acid exerts hepatoprotective effects against alcohol-associated liver disease. Bovinic acid can be used for the research of alcohol-associated liver disease.
Keap1-Nrf2   Ferroptosis   Reactive Oxygen Species (ROS)   SOD  
Cancer   Inflammation or Immune System Disease  
1
HY-W014787 Decanedioic acid
Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
Endogenous Metabolite   PROTAC Linkers  
Type 2 Diabetes   Obesity   Hepatic Fibrosis  
1
HY-113080 N-Acetylornithine
N-Acetylornithine is a precursor of ornithine. N-Acetylornithine is associated with type 2 diabetes.
Others  
Glucose Metabolism  
1
HY-P99165 Teprotumumab
Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.

Species: Human

IGF-1R   TSH Receptor  
Metabolic or Endocrine Disease  
1
HY-P70039 CTCF Protein, Human
CTCF protein is a chromatin-binding factor that plays multiple roles in transcriptional regulation and epigenetic control. It binds to DNA at specific sites and acts as a transcriptional repressor by binding to chromatin insulators to prevent undesirable interactions between promoters and neighboring enhancers or silencers. CTCF Protein, Human is the recombinant human-derived CTCF protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

1
HY-P79315 HMGN1 Protein, Human
The HMGN1 protein is a key player in the immune response, binding to the Fc region of immunoglobulin alpha and specifically promoting the production of cytokines. HMGN1 is intricately related to the Fc epsilon RI gamma 2 receptor, can induce tyrosine phosphorylation of gamma 2, and actively participates in the complex coordination of immune signaling pathways. HMGN1 Protein, Human is the recombinant human-derived HMGN1 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

1
HY-P704230 DENV2 Envelope Protein (HEK293, His)
NS1 Protein, essential in virus budding, binds the cell membrane, forming a nucleocapsid that becomes the virus core. During entry, NS1 facilitates viral genome penetration post-hemifusion. NS1 migrates to the nucleus, influencing host functions, and counteracts host EXOC1's antiviral effects by sequestering and degrading EXOC1 via the proteasome pathway. Additionally, NS1 impedes RNA silencing by interfering with the host Dicer enzyme. DENV2 Envelope Protein (HEK293, His) is the recombinant DENV2 Envelope protein, expressed by HEK293, with N-His labeled tag.

Species: Virus; Source: HEK293

1
HY-K3012 N-2 Supplement (100×), Sterile

This product is serum-free and supports cell growth and survival. It has been associated with the growth and expression of neuroblastoma, and with post-mitotic neuronal survival and expression in primary cultures of both the peripheral nervous system (PNS) and central nervous system (CNS). This product is formulated with water-for-injection. The 5 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Culture Cell Culture Supplements

1
HY-P2465 Histone H3 (1-35)
Histone H3 (1-35) is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells.
DNA/RNA Synthesis  
Cancer  
/
HY-NP185 Chicken Tenascin,suitable for cell culture
Chicken Tenascin,suitable for cell culture is a glycoprotein that forms disulfide-linked hexamers. Chicken Tenascin,suitable for cell culture is composed of repetitive domains, including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Chicken Tenascin,suitable for cell culture can be used for cell culture.
Biochemical Assay Reagents  
/
HY-W725543 Chlorphenesin-d5
Chlorphenesin-d5 is the deuterium labeled Chlorphenesin (HY-A0133). Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics.
Isotope-Labeled Compounds   Bacterial   Fungal  
Inflammation or Immune System Disease  
/
HY-B0667S1 Balsalazide-d4
Balsalazide-d4 is deuterium labeled Balsalazide. Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
Isotope-Labeled Compounds   Interleukin Related   STAT  
Cancer   Inflammation or Immune System Disease  
/
HY-P2253 H3K27(Me2) (15-34)
H3K27(Me2) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).
Histone Demethylase  
Cancer  
/
HY-D3212 Crisp-17
Crisp-17 is a monovalent copper ion probe. Crisp-17 can be used to characterize cellular phenotypes associated with copper metabolism defects. Crisp-17 is applicable to research related to Menkes disease.
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-D2279 NFL-NH2
NFL-NH2 is a mitochondrial-targeted near-infrared ratiometric fluorescent probe. NFL-NH2 can rapidly detect NO levels associated with the inflammatory damage degree in rheumatoid arthritis (RA) mice models by ratiometric fluorescence imaging. The excitation wavelength and emission wavelength are 650 nm and 780 nm, respectively.
Fluorescent Dye  
Inflammation or Immune System Disease  
/
HY-P2252 H3K27(Me) (15-34)
H3K27(Me) (15-34), a histone peptide, is a repressive chromatin markderived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).
Histone Methyltransferase  
Cancer  
/
HY-138794G XL177A (GMP)
XL177A GMP is XL177A (HY-138794) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections.
Deubiquitinase   SARS-CoV   Histone Demethylase  
/
HY-D1771 Thionin perchlorate
Thionin perchlorate is a general nuclear stain for chromatin and mucin.
Fluorescent Dye  
/
HY-D3235 FDOCl-22
FDOCl-22 is a HOCl-responsive probe. FDOCl-22 reacts with hypochlorous acid to significantly enhance near-infrared emission and absorption signals, enabling the detection of HOCl levels associated with reagent-induced acute kidney injury. FDOCl-22 can be used in studies related to reagent-induced acute kidney injury.
Fluorescent Dye  
Renal Disease  
/
HY-137697 ddCTP
ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.
Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis   HIV Protease   HIV   Drug Metabolite  
Viral Infection  
/
HY-P10653 C5A
C5A is a microbicidal peptide, anti-hepatitis C virus (HCV), and anti-HIV agent. C5A disrupts the membrane integrity of the HIV virion as well as the integrity of the conical capsid core that surrounds the viral genome. C5A inhibits in vitro infectivity of a broad range of primary HIV isolates in various primary target cells. C5A protects mice against vaginal and rectal HIV challenges.
HCV   HIV  
Infection  
/
HY-W014125S Undecanedioic acid-d18
Undecanedioic acid-d18 is the deuterium labeled Undecanedioic acid (HY-W014125). Undecanedioic acid is an oral activie nndogenous metabolite. Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N17375 Saikosaponin bk1
Saikosaponin bk1 is a NADPH-oxidase 5(NOX5) dehydrogenase domain binder and hepatoprotective agent. Saikosaponin bk1 forms stable interactions with the dehydrogenase domain of NOX5 from Cylindrospermum stagnale. Saikosaponin bk1 is applicable to research related to COVID-19 and alcoholic liver injury.
NADPH Oxidase  
SARS-CoV-2 Infection   Liver Injury  
/
HY-P10567 Pip6a
Pip6a is an arginine-rich cell-penetrating peptide. Pip6a has the ability to deliver associated cargoes across the plasma and endosomal membranes and is stable to serum proteolysis. Pip6a is composed of a hydrophobic core region flanked on each side by arginine-rich domains containing β-alanine and aminohexanoyl spacers. Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced antisense oligonucleotide (ASO) delivery into striated muscles of myotonic dystrophy (DM1) mice.
Others  
/
HY-175875 HRZ-01-082-5
HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8  nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research.
Molecular Glues   Zinc Finger Protein   Drug Derivative  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-D3352 EMI-137
EMI-137 (AGSCYCSGPPRFECWCYETEGT-Cy5) is a fluorescent imaging agent targeting the c-Met receptor. EMI-137 specifically binds to the extracellular domain of the c-Met receptor and is used for fluorescent visualization of c-Met-expressing cells and tissues. EMI-137 can be applied to research related to colorectal cancer.
Fluorescent Dye   c-Met/HGFR  
Colorectal Cancer  
/
HY-P11643 LVV-hemorphin-7
LVV-hemorphin-7 is an Angiotensin IV receptor ligand and IRAP inhibitor (IC50s: 17.6 nM for sheep adrenal IRAP; 5.0 nM for sheep cerebellum IRAP). LVV-hemorphin-7 inhibits the catalytic activity of IRAP. LVV-hemorphin-7 stimulates DNA synthesis. LVV-hemorphin-7 elicits a number of physiological effects, including cellular proliferation and memory enhancement.
Angiotensin Receptor   Aminopeptidase   DNA/RNA Synthesis  
Alzheimer's Disease  
/
HY-135146G GSK-3484862 (GMP)
GSK-3484862 GMP is GSK-3484862 (HY-135146) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. GSK-3484862 is a highly potent non-covalent inhibitor and demethylating agent of DNMT1. GSK-3484862 induces genome-wide DNA demethylation, including the regulatory elements of DNMT3B and the promoter region of TERT, and significantly inhibits cell viability, growth, proliferation and self-renewal. GSK-3484862 blocks the transformation of young AT2 cells, induces apoptosis, and generates transcriptomic features similar to those of senescent cells. GSK-3484862 is widely used in studies related to lung cancer, oral squamous cell carcinoma and lung adenocarcinoma.
DNA Methyltransferase   Apoptosis  
/
HY-183629 ZNF281-IN-1
ZNF281-IN-1 is a ZNF281 inhibitor. ZNF281-IN-1 disrupts the binding of transcriptionally active DNA-bound ZNF281 to the promoters of target genes including TRIM35 and ZEB1. ZNF281-IN-1 inhibits tumor cell proliferation, stabilizes P53 and upregulates PUMA to induce apoptosis, while triggering cellular senescence. ZNF281-IN-1 completely prevents Doxorubicin (HY-15142A)-induced cardiotoxicity (AIC), and enhances rather than impairs the antitumor efficacy of Doxorubicin. ZNF281-IN-1 completely blocks the distant metastasis of melanoma to the lungs. ZNF281-IN-1 can be used in the research of cardiotoxicity, lung cancer and metastatic melanoma.
Zinc Finger Protein   Apoptosis  
Lung Cancer   Heart Disease   Mutant Melanoma  
/
HY-P5307A Peptide A5K acetate
Peptide A5K (INF7-A5K-TAT) acetate is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K acetate can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K acetate enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy.
Biochemical Assay Reagents  
/
HY-P10563 Noraramtide
Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma.
CD38   IFNAR  
Leukemia/Lymphoma/Myeloma  
/
HY-W854392 3-Carboxyumbelliferyl-β-D-glucuronide dipotassium
3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) is a chromogenic substrate with biological activity for enzyme activity detection. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) can be used to evaluate biological reactions associated with glycosidases. 3-Carboxyumbelliferyl-β-D-glucuronide (dipotassium) shows a wide range of application potentials in compound discovery and biomedical research.
Biochemical Assay Reagents  
/
HY-180281 PLAGL2-IN-1
PLAGL2-IN-1 is a inhibitor of pleiomorphic adenoma-like protein 2 (PLAGL2) with a Kd of 2.23 µM. PLAGL2-IN-1 suppresses PLAGL2 transcriptional activity, induces G0/G1 cell cycle arrest, and apoptosis, thereby inhibiting hepatocellular carcinoma (HCC) cell proliferation. PLAGL2-IN-1 disrupts extracellular matrix organization and suppresses the PI3K-AKT pathway by reducing AKT phosphorylation. PLAGL2-IN-1 inhibits tumor growth in an HCCLM3 xenograft mouse model. PLAGL2-IN-1 can be used for the research of HCC.
Zinc Finger Protein   Apoptosis   PI3K   Akt  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-P991546 MEDI-552
MEDI-552 is a human IgG monoclonal antibody targeting CD20/membrane-spanning 4-domains subfamily A member 1 (MS4A1).

Species: Human

CD20  
Cancer  
/
HY-E70162 Carbohydrate Sulfotransferase 2
Carbohydrate Sulfotransferase 2 (EC:2.8.2.-) can catalyze sulphate transfer to position 6 of non-reducing GlcNAc residues within keratan-like structures on N-linked glycans and within mucin-associated glycans.
Others  
Cancer  
/
HY-159570 XD2-149
XD2-149 is a ZFP91 PROTAC degrader with DC50 values of 0.08 μM and 0.06 μM, respectively. ZFP91 is a bifunctional nuclear protein with both transcription factor and E3 ubiquitin ligase activities, and is classified as an oncogenic non-canonical NF-κB pathway regulator in tumor and immune regulation. XD2-149 induces proteasome-dependent degradation of the E3 ubiquitin-protein ligase ZFP91. XD2-149 inhibits the STAT3 signaling pathway in pancreatic cancer cells and induces NQO1-dependent cell death independent of ZFP91 degradation. XD2-149 can be used for the research of pancreatic cancer.
PROTACs   Zinc Finger Protein   STAT   NF-κB   Quinone Reductase  
Pancreatic Cancer  
/
HY-P10999 INF7TAT-P55
INF7TAT-P55 (P55) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing.
Drug Derivative   Biochemical Assay Reagents  
/
HY-108398BR 11(Z),14(Z),17(Z)-Eicosatrienoic acid (Standard)
11(Z),14(Z),17(Z)-Eicosatrienoic acid (Standard) is the analytical standard of 11(Z),14(Z),17(Z)-Eicosatrienoic acid (HY-108398B). This product is intended for research and analytical applications. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is an unsaturated fatty acid that affects mitochondrial genome maintenance. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid fully incorporates into cell membrane phospholipids and supports the initial induction of cellular respiration, but fails to sustain the continuous replication and retention of mitochondrial genomes. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is applicable to research related to fatty acid acyl chain structure-dependent mitochondrial genome maintenance and mitochondrial biogenesis.
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-13271AG Tubastatin A (GMP)
Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
HDAC   Beta-lactamase   Autophagy   Apoptosis  
Cancer  
/
HY-P4110 TAT-NSF222 Fusion Peptide
TAT-NSF222 Fusion Peptide is a fusion polypeptide with two domains, a TAT domain, which enters cells through macropinocytosis, and an NSF domain that inhibits N-ethylmaleimide-sensitive factor (NSF). TAT-NSF222 Fusion Peptide is an exocytosis inhibitor.
iGluR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P991784 Anti-Mouse/Human EGFR (domain III) Antibody (EMab-88)
Anti-Mouse/Human EGFR (domain III) Antibody (EMab-88) reacts with domain III of the mouse and human EGFR. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Mouse/Human

EGFR  
/
HY-159060 Coriolus Versicolor Extract
Coriolus Versicolor Extract is a biological response modifier (BRM) with anti-cancer and anti-migratory properties. Coriolus Versicolor Extract can also inhibit the expression of tumorigenic factors associated with inflammation and can be used in cancer research.
MMP   Interleukin Related   Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-P991783 Anti-Mouse EGFR (domain I) Antibody (EMab-300)
Anti-Mouse EGFR (domain I) Antibody (EMab-300) reacts with domain I of the mouse EGFR. Anti-Mouse EGFR (domain I) Antibody (EMab-300) applies to the detection of mouse EGFR using flow cytometry. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).

Species: Mouse

EGFR  
/
HY-173256 Hyp-dBET1
Hyp-dBET1 is a hypoxia-activated BRD4 PROTAC degrader. The IC50 of Hyp-dBET1 for reducing cell viability under hypoxic conditions is approximately 153 nM to 192 nM, while it shows low activity under normoxic conditions (IC50 of approximately 2.8 μM to 3.8 μM). Hyp-dBET1 induces BRD4 degradation under hypoxic conditions, converts to dBET1 in hypoxic environments, and downregulates the expression level of ZFP-91. Hyp-dBET1 can be used in studies related to breast cancer, cervical cancer and solid tumors.
PROTACs   Epigenetic Reader Domain   Zinc Finger Protein  
Breast Cancer   Cervical Cancer  
/
HY-P11137 LANA
LANA is a KSHV latency-associated nuclear antigen. The core function of LANA is to act as an "anchor" for the viral genome, attaching it to the chromatin of the host cell. LANA ensures that the episomal DNA of KSHV replicates together with the host chromosome and is evenly distributed among the daughter cells, thereby maintaining the latent infection of the virus in the cell population. LANA can regulate the transcription of viral and host cell genes, and regulate certain host cell genes to promote cell survival. LANA can be used to study the viral DNA tethering structure.
HSV  
Cancer  
/
HY-D2204 SHP1-IN-1
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM).
Phosphatase   SHP1   Fluorescent Dye  
Cancer  
/
HY-134505 Avicin G
Avicin G is a sphingomyelinase inhibitor and plasma membrane disruptor. Avicin G inhibits the enzymatic activities of neutral sphingomyelinases (SMPD2/3) and acid sphingomyelinase (SMPD1), elevates intracellular sphingomyelin levels, and alters the distribution of sphingomyelin. Avicin G interferes with the lateral segregation of GTP- and GDP-bound H-Ras, inhibits the signal output of oncogenic K-Ras and H-Ras, reduces the phosphorylation of ERK and Akt, increases lysosomal pH, and inhibits the endocytic recycling of epidermal growth factor receptor. Avicin G can be used in research related to pancreatic ductal adenocarcinoma and non-small cell lung cancer.
Ras   Phospholipase   ERK   Akt  
Non-Small Cell Lung Cancer   Pancreatic Ductal Adenocarcinoma  
/
HY-166594S Deucravacitinib-13C,d3
Deucravacitinib-13C,d3 is the 13C- and deuterium labeled Deucravacitinib. Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis.
Isotope-Labeled Compounds   JAK   Interleukin Related   IFNAR  
Inflammation or Immune System Disease  
/
HY-13689G Go 6983 (GMP)
Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury.
PKC   Histone Methyltransferase   DNA Methyltransferase   DNA/RNA Synthesis  
Ischemia-Reperfusion Injury  
/
HY-N10241 Hortein
Hortein is a natural product from the fungus Hortaea werneckii associated with the sponge Aplysina aerophoba.

Source: fungus Hortaea werneckii 

Others  
/
HY-B1718R Choline theophyllinate (Standard)
Choline theophyllinate (Standard) (Oxtriphylline (Standard)) is the analytical standard of Choline theophyllinate (HY-B1718). This product is intended for research and analytical applications. Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.
Reference Standards   Histamine Receptor  
Respiratory Disease   Sleep-Wake Disorder   Cardiovascular Disease   Urologic Disease  
/
HY-N11872 Suffruticosol A
Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora.
Others  
Neurological, Eye or Ear Disease  
/
HY-W700491 AalphaC-15N3
AalphaC-15N3 (2-Amino-α-carboline-15N3) is 15N labeled AalphaC. AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer  
/
HY-N0005S1 Curcumin-d3
Curcumin-d3 (Diferuloylmethane-d3 ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
Isotope-Labeled Compounds   Keap1-Nrf2   Epigenetic Reader Domain   Histone Acetyltransferase   Mitophagy   Autophagy   Influenza Virus   Ferroptosis  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P2788 Hyp-Phe-Phe
Hyp-Phe-Phe is a tripeptide that forms helical-like sheets via aromatic interactions of the Phe rings to comprise a cross helical architecture. Hyp-Phe-Phe possesses a high shear piezoelectricity and acts as piezoelectric material.
Others  
/
HY-B0432AS2 Propafenone-d5 hydrochloride
Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
Isotope-Labeled Compounds   Sodium Channel  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990955 Ebribafusp alfa
Ebribafusp alfa (ADX-097) comprising a humanized anti-C3d monoclonal antibody linked to two moieties of the first five consensus repeats of factor H (fH1-5). Ebribafusp alfa binds C3d and related fragments, catalyzes AP convertase dissociation, acts as a factor I co-factor for C3b cleavage, and delivers fH1-5 moieties to C3d-deposited tissues for local complement inhibition without systemic blockade. Ebribafusp alfa reduces glomerular C3 deposition, proteinuria, urine albumin-creatinine ratios, and urine soluble C5b-9 levels, preserves podocyte foot-process architecture, inhibits skin complement activation, and localizes to UVB-damaged primate skin. Ebribafusp alfa can be used for the research of membranous nephropathy, bullous pemphigoid, discoid lupus erythematosus, C3 glomerulopathy, IgA nephropathy, and lupus nephritis.

Species: Human

CD3   Complement System  
Lupus Erythematosus   Chronic Kidney Disease   Nephritis  
/
HY-121199 Germanicol
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage.
Apoptosis  
/
HY-140696D m-PEG10000-OH
m-PEG10000-OH (mPEG10000-Hydroxy; Polyethylene glycol monomethyl ether 10000) is a hydroxyl-terminated methoxylated polyethylene glycol (PEG-based) compound that serves as a linker for PROTACs. m-PEG10000-OH is applicable to research on healthcare-associated infections.
Environmental Pollutants   PROTAC Linkers  
Infection  
/
HY-P991149 Nesfrotamig
Nesfrotamig (YH32367; ABL105) is a bispecific activator targeting HER2 and 4-1BB. The Kd values of Nesfrotamig for human HER2 and human 4-1BB are 0.48 nM and 3.36 nM, respectively. By blocking tumor cell growth signals, activating HER2-dependent local 4-1BB in tumors to maintain T cell survival, and inducing NK cell-mediated antibody-dependent cellular cytotoxicity, Nesfrotamig enhances the cytotoxicity and tumor infiltration ability of immune cells. Nesfrotamig promotes the generation of tumor-specific memory T cells, drives T cell-mediated tumor lysis, exhibits significant anti-tumor efficacy against both HER2-positive and HER2-low-expressing tumors, and shows synergistic activity when combined with anti-PD-1 antibodies. In cynomolgus monkey studies, Nesfrotamig demonstrates good safety and is suitable for research related to HER2-positive and HER2-low-expressing tumors.

Species: Human

TNF Receptor  
Breast Cancer   HER2-Positive Gastric Cancer  
/
HY-P1985A Notch 1 TFA
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.
Notch  
Blood or Cardio-cerebrovascular Disease  
/
HY-148043 Schnurri-3 inhibitor-1
Schnurri-3 inhibitor-1 is a potent schnurri-3 inhibitor which is an essential regulator of adult bone formation. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in osteoblast cell line Shn3FFL with an AC50 value of 2.09 μM. Schnurri-3 inhibitor-1 can be used to research osteoporosis.
Zinc Finger Protein  
/
HY-P10366 WEYIPNV
WEYIPNV is a ligand for SurA, specifically binding to the P1 domain of SurA (Kd: 1-14 μM). The binding of WEYIPNV promotes the release of the P1 domain from the core domain.
Others  
Infection  
/
HY-146127 Grb2 SH2 domain inhibitor 1
Grb2 SH2 domain inhibitor 1 is an inhibitor of the Grb2 SH2 domain with an IC50 of 0.40 μM. Grb2 SH2 domain inhibitor 1 is also a cell-permeable cyclic peptide that can enter the cytosol of mammalian cells. Grb2 SH2 domain inhibitor 1 downregulates the expression level of p-MEK. Grb2 SH2 domain inhibitor 1 can be used in the research of breast cancer.
MEK  
Breast Cancer  
/
HY-W014787S Decanedioic acid-d4
Decanedioic acid-d4 is the deuterium labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P1985 Notch 1
Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.
Notch  
Blood or Cardio-cerebrovascular Disease  
/
HY-169675 Lacripep
Lacripep is a synthetic tear protein. Lacripep binds to and activates syndecan-1 (SDC1). Lacripep restores progenitor cell identity and epithelial barrier function. Lacripep resolves dry eye.
Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P10999A INF7TAT-P55 acetate
INF7TAT-P55 acetate (P55 acetate) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 acetate serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing.
Drug Derivative   Biochemical Assay Reagents  
/
HY-W740027 5-Methyl-2'-deoxycytidine-d3
5-Methyl-2'-deoxycytidine-d3 (5-Methyldeoxycytidine-d3) is the deuterium labeled Methyl-2'-deoxycytidine (HY-W012078). 5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells.
Isotope-Labeled Compounds   Endogenous Metabolite   DNA Methyltransferase  
/
HY-120317 CPTH2-Alkyne
CPTH2-Alkyne is a cell active analog of CPTH2 (HY-W013274). CPTH2-Alkyne specifically accumulates in nucleoli and locates in nuclear periphery and in cytoplasma. CPTH2-Alkyne inhibits N-acetyltransferase 10 (NAT10). CPTH2-Alkyne is used in study of nuclear architecture and application in laminopathy.
Histone Acetyltransferase  
/
HY-113006 3-Methylglutarylcarnitine
3-Methylglutarylcarnitine is a biomarker of disease associated with compromised mitochondrial energy metabolism.
Endogenous Metabolite  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P99562 Tidutamab
Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and T-cell binding domain (CD3). Tidutamab possesses a full Fc domain to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC).

Species: Human

CD3  
Cancer  
/
HY-161303 ZNF207-IN-1
ZNF207-IN-1 is an orally active and brain-penetrant ZNF207 inhibitor with a target KD of 67 nM. ZNF207-IN-1 binds directly to ZNF207, downregulates stem-related genes and weakens glioma cell stemness. ZNF207-IN-1 hinders tumorigenesis and migration and promotes apoptosis. ZNF207-IN-1 can be used for the research of glioma[1].
Zinc Finger Protein   Apoptosis  
Glioma  
/
HY-P10426 cyclo(CLLFVY)
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers.
HIF/HIF Prolyl-Hydroxylase   VEGFR  
Cancer  
/
HY-P2254 H3K27(Me3) (15-34)
H3K27(Me3) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).
Histone Methyltransferase  
Cancer  
/
HY-W543137 PT-ttpy
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
G-quadruplex   Mitosis   DNA/RNA Synthesis  
Cancer  
/
HY-P990736 Efercoleukin alfa
Efercoleukin alfa (XTX-202) is an IL-2 Rβ-biased IL-2 which has a masking domain to prevent IL-2 activity in non-tumor regions along with a half-life extension domain. The masking domain is cleaved by matrix metalloproteases (MMP) in the TME, leading to the release of the IL-2 R agonist. Efercoleukin alfa shows potential immunoregulatory and antineoplastic activities.

Species: Human

Interleukin Related  
Cancer   Inflammation or Immune System Disease  
/
HY-P2258 Histone H3 (1-34)
Histone H3 (1-34) is a peptide derived from human histone isotype 3.1. Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA.
Histone Methyltransferase  
/
HY-126242S Tyk2-IN-7
Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis.
JAK   IFNAR   Interleukin Related  
Inflammation or Immune System Disease  
/
HY-76585 Paricalcitol-d6
Paricalcitol-d6 is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
VD/VDR  
Metabolic or Endocrine Disease  
/
HY-P1195 PDZ1 Domain inhibitor peptide
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain.
iGluR  
Neurological, Eye or Ear Disease  
/
HY-P99306 Modotuximab
Modotuximab (DS 1024) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab binds non-overlapping epitopes on domain III of EGFR, a domain that is intact in EGFRvIII. Modotuximab has antitumor activity in vivo.

Species: Human

EGFR  
Cancer  
/
HY-W008951 Ethylenediaminetetra(methylenephosphonic acid)
Ethylenediaminetetramethylenephosphonic acid (EDTMP) is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with 153Sm and 177Lu. Ethylenediaminetetramethylenephosphonic acid is used to study palliative therapy for pain associated with multiple bone metastatic cancers.
Radionuclide-Drug Conjugates (RDCs)  
Pain   Multiple Myeloma  
/
HY-P2465A Histone H3 (1-35) TFA
Histone H3 (1-35) TFA is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells.
DNA/RNA Synthesis  
Cancer  
/
HY-P10506 CMX-8933
CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin. CMX-8933 increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increases the phosphorylation of JNK and c-Jun proteins, and increases the cellular levels of c-Jun and c-Fos mRNA. CMX-8933 can be used to study the role of ependymin in neuroplasticity, learning, memory formation, and neural regeneration.
JNK  
Pain  
/
HY-B1648 Ferric pyrophosphate
Ferric pyrophosphate is an orally effective anti-inflammatory agent and iron fortifier. Ferric pyrophosphate downregulates the expression of colonic pro-inflammatory cytokines, modulates the intestinal flora, and corrects the dysbiosis associated with iron deficiency anemia (IDA). Ferric pyrophosphate can be used in studies related to iron deficiency anemia.
Biochemical Assay Reagents  
Blood Disease  
/
HY-W088068 Wright's stain
Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities.
Fluorescent Dye  
/
HY-N0005S Curcumin-d6
Curcumin-d6 (Diferuloylmethane-d6 ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
Isotope-Labeled Compounds   Keap1-Nrf2   Ferroptosis   Autophagy   Histone Acetyltransferase   Epigenetic Reader Domain   Mitophagy   Influenza Virus  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-NP175 Collagen (bovine skin)
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development.
Biochemical Assay Reagents   Integrin   Discoidin Domain Receptor  
/
HY-108398B 11(Z),14(Z),17(Z)-Eicosatrienoic acid
11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is an unsaturated fatty acid that affects mitochondrial genome maintenance. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid fully incorporates into cell membrane phospholipids and supports the initial induction of cellular respiration, but fails to sustain the continuous replication and retention of mitochondrial genomes. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is applicable to research related to fatty acid acyl chain structure-dependent mitochondrial genome maintenance and mitochondrial biogenesis.

Source: Saccharomyces cerevisiae

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-B1337R Choline chloride (Standard)
Choline chloride (Standard) is the analytical standard of Choline chloride (HY-B1337). This product is intended for research and analytical applications. Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.
Reference Standards   Histamine Receptor  
Respiratory Disease   Sleep-Wake Disorder   Cardiovascular Disease   Urologic Disease  
/
HY-P5904 Caveolin-1 (82-101) amide (human, mouse, rat)
Caveolin-1 (82-101) amide (human, mouse, rat) (Caveolin-1 scaffolding domain peptide) is a peptide that reverses aging-associated deleterious changes in multiple organs. Caveolin-1 (82-101) amide (human, mouse, rat) inhibits tyrosine kinases.
c-Met/HGFR  
/
HY-B1411S i-Inositol-d6
i-Inositol-d6 is the deuterium labeled i-Inositol. i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges.
Endogenous Metabolite  
/
HY-P10108 Hexokinase II VDAC binding domain peptide, cell-permeable
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth.
Hexokinase  
Neurological, Eye or Ear Disease  
/
HY-113144 L-Hexanoylcarnitine
L-Hexanoylcarnitine is an acylcarnitine and is found to be associated with celiac disease.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-403538 iZMYND8-34
iZMYND8-34 is a ZMYND8 inhibitor with an IC50 of 0.66 μM. iZMYND8-34 inhibits the binding of H3K4me1–H3K14ac peptide to the ZMYND8 protein. iZMYND8-34 inhibits ZMYND8’s histone recognition. iZMYND8-34 blocks neuroendocrine prostate cancer development.
Zinc Finger Protein  
Prostate Cancer  
/
HY-D1435 Oxonol VI
Oxonol VI is an optical indicator of membrane potential in lipid vesicles (excitation/emission wavelengths: 614/646 nm). Oxonol VI can be used to detect changes in membrane potential associated with (Na+ + K+)-ATPase activity in reconstituted vesicles.
Na+/K+ ATPase   Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-108822 Rilonacept
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P5307 Peptide A5K
Peptide A5K (INF7-A5K-TAT) is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy.
Biochemical Assay Reagents  
/
HY-P990748 Lunsekimig
Lunsekimig (SAR443765) is a nanobody composed of 5 VH domains that targets both TSLP and IL-13. Lunsekimig blocks the functional effects of TSLP and IL-13, inhibits related inflammatory signals, and improves lung function associated with type 2 inflammation. Lunsekimig can be used in research on asthma and type 2 inflammation.

Species: Human

Interleukin Related  
Asthma  
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HY-P99339 Tebentafusp
Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells.

Species: Human

Interleukin Related   TNF Receptor  
Cancer  
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HY-Y0649D Lithium chloride, 99%
Lithium chloride, for molecular biology, 99% can be used in the preparation of wash buffers for chromatin immunoprecipitation. Lithium chloride, for molecular biology, 99% is a kind of biological materials or organic compounds that are widely used in life science research.
Environmental Pollutants   Biochemical Assay Reagents  
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HY-P79151A TEV Protease Protein, Tobacco etch virus (S2256N, C-His)
The TEV protease is critical in aphid transmission and has proteolytic activity that cleaves the Gly-Gly dipeptide at its C terminus. In addition to proteolysis, it interacts with virions and aphid stylets, which is critical for aphid transmission. TEV Protease Protein, Tobacco etch virus (S2256N, C-His) is the recombinant Virus-derived TEV Protease protein, expressed by E. coli , with C-6*His labeled tag.

Species: Virus; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P70878A EDIL3 Protein, Human (HEK293, His)
EDIL3 Protein enhances endothelial cell adhesion by interacting with the alpha-v/beta-3 integrin receptor, while also inhibiting the formation of vascular-like structures. Its role suggests involvement in the regulation of vascular morphogenesis during embryonic development. EDIL3 Protein, Human (HEK293, His) is the recombinant human-derived EDIL3 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P71362 TIE-1 Protein, Human (HEK293, His)
TIE-1, a transmembrane kinase, modulates TEK/TIE2 activity, actively participating in the intricate regulation of angiogenesis. TIE-1 Protein, Human (HEK293, His) is the recombinant human-derived TIE-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators Angiopoietins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases TIE Receptors TIE-1

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HY-P76970 HHLA2 Protein, Human (HEK293, Fc)
HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Human (HEK293, Fc) is the recombinant human-derived HHLA2 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

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HY-P701528 HLTF Protein, Human
HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Enzymes & Regulators Ubiquitin Related Proteins Transferases (EC 2) Ubiquitin Enzymes E3 Ligases

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HY-P74601 RBBP4 Protein, Human (sf9, His)
The RBBP4 protein regulates chromatin assembly by binding to core histones and interacting with chromatin assembly factors, remodelers, and histone deacetylases. Its activity is determined by its interaction with nucleosomal DNA. RBBP4 Protein, Human (sf9, His) is the recombinant human-derived RBBP4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P76491 MEGF10 Protein, Human (HEK293, His)
The MEGF10 protein is a membrane receptor that plays a key role in phagocytosis by macrophages and astrocytes, specifically the clearance of apoptotic cells through C1q binding to phosphatidylserine. MEGF10 cooperates with ABCA1 to contribute to the formation of large vacuoles and may facilitate amyloid-beta peptide uptake. MEGF10 Protein, Human (HEK293, His) is the recombinant human-derived MEGF10 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P76971 HHLA2 Protein, Human (HEK293, His)
HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Human (HEK293, His) is the recombinant human-derived HHLA2 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P7985 SMARCA2 Protein, Human (P.pastoris, His)
SMARCA2 Protein, Human(P.pastoris, His) is a subunit of the Switch/Sucrose non-fermenting (SWI/SNF) complex, which play an important role in chromatin remodeling and regulation of downstream gene expression in neural development.

Species: Human; Source: P. pastoris

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HY-P78927 HHLA2 Protein, Human (Biotinylated, HEK293, Fc-Avi)
HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived HHLA2 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

Species: Human; Source: HEK293

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HY-P70926 LMCD1 Protein, Human (His)
The LMCD1 protein is a transcriptional cofactor that regulates GATA6 by blocking its DNA binding, thereby inhibiting transcriptional activation in lung and heart tissues. It inhibits GATA6-mediated transactivation of tissue-specific promoters, which is critical for developmental processes. LMCD1 Protein, Human (His) is the recombinant human-derived LMCD1 protein, expressed by E. coli , with N-6*His, C-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P71588 CHD1L Protein, Human (His-SUMO)
CHD1L protein is the ATP-binding subunit of the mitochondrial potassium channel and cooperates with CCDC51/MITOK to form a complex to promote ATP-dependent potassium current across the inner membrane (mitoK(ATP) channel). ABCB8 is essential for mitochondrial iron transport, affects cardiac function, and regulates the maturation of cytosolic iron-sulfur-containing enzymes. CHD1L Protein, Human (His-SUMO) is the recombinant human-derived CHD1L protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P74600 RBBP4 Protein, Mouse (sf9, His)
The RBBP4 protein is a core histone-binding subunit that directs chromatin regulators and histone deacetylases to their substrates and participates in chromatin metabolism.RBBP4 Protein, Mouse (sf9, His) is the recombinant mouse-derived RBBP4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

Species: Mouse; Source: Sf9 insect cells

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HY-P75810 HMGN3 Protein, Human (His)
HMGN3 binds to nucleosomes, regulates chromatin structure, and affects chromatin-dependent processes such as transcription and DNA repair. It affects insulin and glucagon levels and regulates pancreatic gene expression related to insulin secretion. HMGN3 Protein, Human (His) is the recombinant human-derived HMGN3 protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

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HY-P78597 HHLA2 Protein, Cynomolgus (HEK293, His)
HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived HHLA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of HHLA2 Protein, Cynomolgus (HEK293, His) is 325 a.a., with molecular weight of 60-70 kDa.

Species: Cynomolgus; Source: HEK293

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HY-P76389 Enterovirus 71 VP0 Protein (sf9, His-GST)
The enterovirus 71 VP0 protein forms a 300 angstrom icosahedral capsid with the VP2 and VP3 proteins.Enterovirus 71 VP0 Protein (sf9, His-GST) is the recombinant Virus-derived Enterovirus 71 VP0 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag.

Species: Virus; Source: Sf9 insect cells

Viral Proteins

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HY-P702052 CHMP6 Protein, Human
The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human is the recombinant human-derived CHMP6 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

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HY-P702982 RANGAP1 Protein, Human (His)
RANGAP1 Protein, Human (His) is the recombinant human-derived RANGAP1, expressed by E. coli , with His labeled tag. ,

Species: Human; Source: E. coli

Enzymes & Regulators

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HY-P703421 SPT16 Protein, Arabidopsis thaliana
SPT16 Protein, Arabidopsis thaliana is the recombinant SPT16, expressed by E. coli , with tag Free labeled tag. ,

Species: Others; Source: E. coli

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HY-P701529 HLTF Protein, Human (His)
HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Ubiquitin Related Proteins Transferases (EC 2) Ubiquitin Enzymes E3 Ligases

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HY-P701611 BPTF Protein, Human
BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human is the recombinant human-derived BPTF protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

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HY-P701612 BPTF Protein, Human (His)
BPTF proteins are regulatory subunits in the NURF-1 and NURF-5 ISWI chromatin remodeling complexes that assemble ordered nucleosome arrays to access DNA during replication, transcription, and repair. The NURF-1 complex is critical for brain development and actively regulates the expression of En1 and En2. BPTF Protein, Human (His) is the recombinant human-derived BPTF protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P701613 CECR2 Protein, Human (His)
The CECR2 protein is a regulatory subunit in the CERF-1 and CERF-5 ISWI chromatin remodeling complexes that assembles ordered nucleosome arrays to help DNA enter replication, transcription, and repair. Despite lacking mononucleosome sliding ability, these complexes make crucial contributions to various developmental processes. CECR2 Protein, Human (His) is the recombinant human-derived CECR2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P701920 3C protease Protein, Human rhinovirus 14
The 3C protease protein forms an icosahedral capsid with the VP2 and VP3 proteins, with a diameter of 300 angstroms. 3C protease Protein, Human rhinovirus 14 is the recombinant Virus-derived 3C protease protein, expressed by E. coli , with tag free.

Species: Virus; Source: E. coli

Viral Proteins

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HY-P701921 3C protease Protein, Human rhinovirus 14 (GST)
The 3C protease protein forms an icosahedral capsid with the VP2 and VP3 proteins, with a diameter of 300 angstroms. 3C protease Protein, Human rhinovirus 14 (GST) is the recombinant Virus-derived 3C protease protein, expressed by E. coli , with N-GST labeled tag.

Species: Virus; Source: E. coli

Viral Proteins

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HY-P702053 CHMP6 Protein, Human (His, StrepⅡ)
The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human (His, Strep) is the recombinant human-derived CHMP6 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P704569 EDIL3 Protein, Human (HEK293, Fc)
EDIL3 Protein enhances endothelial cell adhesion by interacting with the alpha-v/beta-3 integrin receptor, while also inhibiting the formation of vascular-like structures. Its role suggests involvement in the regulation of vascular morphogenesis during embryonic development. EDIL3 Protein, Human (HEK293, Fc) is the recombinant human-derived EDIL3 protein, expressed by HEK293, with C-hFc labeled tag.

Species: Human; Source: HEK293

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HY-P704580 Enterovirus 71 VP0 Protein (Sf9, His)
The enterovirus 71 VP0 protein forms a 300 angstrom icosahedral capsid with the VP2 and VP3 proteins. Enterovirus 71 VP0 Protein (Sf9, His) is the recombinant virus-derived Enterovirus 71 VP0 protein, expressed by sf9 insect cells, with N-His labeled tag.

Species: Virus; Source: sf9 insect cells

Viral Proteins

/
HY-P705142 HHLA2 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)

Species: Cynomolgus; Source: HEK293

Biotinylated Proteins

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HY-P706140 POLG Protein, Hepatitis C virus genotype 1b (435a.a)
POLG proteins play multiple roles in the viral life cycle, contributing to viral RNA packaging, budding, and particle production. It exhibits RNA-binding and RNA chaperone activities, affecting translation initiation through interactions with viral IRES and ribosomal subunits. POLG Protein, Hepatitis C virus genotype 1b (435a.a) is the recombinant Virus-derived POLG protein, expressed by E. coli , with tag free.

Species: Virus; Source: E. coli

Enzymes & Regulators

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HY-P80353 SUZ12 Antibody (YA044)
SUZ12 Antibody (YA044) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUZ12.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83721 WTAP Antibody
WTAP Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to WTAP.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P85636 FADD Antibody (YA5328)
FADD Antibody (YA5328) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FADD.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P88276 LMCD1 Antibody (YA7960)
LMCD1 Antibody (YA7960) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LMCD1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82825 CTCF Antibody (YA2570)
CTCF Antibody (YA2570) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTCF.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84357 CTCF Antibody (YA4054)
CTCF Antibody (YA4054) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CTCF.

Host: Mouse; Reactivity: Human, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P89689 EED Antibody (YA9033)
EED Antibody (YA9033) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EED.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Primary Antibodies

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HY-P80939 MYSM1 Antibody
MYSM1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MYSM1.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

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HY-P811765 SSRP1 Antibody (YA10236)
SSRP1 Antibody (YA10236) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to SSRP1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811765A SSRP1 Antibody (YA10236) (PBS only)
SSRP1 Antibody (YA10236) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to SSRP1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81743 p150 CAF1 Antibody (YA1488)
p150 CAF1 Antibody (YA1488) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p150 CAF1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P85564 SMARCC1 Antibody (YA5256)
SMARCC1 Antibody (YA5256) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SMARCC1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P80894 SMC1A Antibody (YA673)
SMC1A Antibody (YA673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMC1A.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P80894A SMC1A Antibody (YA673)(PBS only)
SMC1A Antibody (YA673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMC1A.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P811921 CHMP7 Antibody(YA10392)
CHMP7 Antibody(YA10392) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHMP7.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811921A CHMP7 Antibody(YA10392) (PBS only)
CHMP7 Antibody(YA10392) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHMP7.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81743A p150 CAF1 Antibody (YA1488)(PBS only)
p150 CAF1 Antibody (YA1488) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p150 CAF1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81912 WTAP Antibody (YA1657)
WTAP Antibody (YA1657) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WTAP.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82825A CTCF Antibody (YA2570)(PBS only)
CTCF Antibody (YA2570) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTCF.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83440 SUZ12 Antibody (YA3185)
SUZ12 Antibody (YA3185) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUZ12.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84357A CTCF Antibody (YA4054)(PBS only)
CTCF Antibody (YA4054) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CTCF.

Host: Mouse; Reactivity: Human, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P85112 CTCF Antibody (YA4804)
CTCF Antibody (YA4804) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CTCF.

Host: Mouse; Reactivity: Human, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P85502 SMC1A(N-term) Antibody (YA5194)
SMC1A(N-term) Antibody (YA5194) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SMC1A(N-term).

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P85503 SMC1A(C-term) Antibody (YA5195)
SMC1A(C-term) Antibody (YA5195) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SMC1A(C-term).

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86221 CTCF Antibody (YA5913)
CTCF Antibody (YA5913) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTCF.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86786 BAF170 Antibody (YA6479)
BAF170 Antibody (YA6479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAF170.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87031 Phospho-SMC1 (S957) Antibody (YA6724)
Phospho-SMC1 (S957) Antibody (YA6724) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-SMC1 (S957).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P87412 LRP4 Antibody (YA7100)
LRP4 Antibody (YA7100) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LRP4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88276A LMCD1 Antibody (YA7960)(PBS only)
LMCD1 Antibody (YA7960) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LMCD1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P89133 HHLA3 Antibody (YA8817)
HHLA3 Antibody (YA8817) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HHLA3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P89133A HHLA3 Antibody (YA8817)(PBS only)
HHLA3 Antibody (YA8817) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HHLA3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P811291 ARL8B Antibody
ARL8B Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ARL8B.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P87955 SA2 Antibody (YA7640)
SA2 Antibody (YA7640) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SA2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-K0606 Methenamine Silver Stain Kit For Basement Membrane (PASM)

MCE Methenamine Silver Stain Kit For Basement Membrane (PASM) is developed based on the classical staining principle. Through an optimized staining system and standardized reagent combination, it enables clear visualization of basement membranes and related reticular structures in tissue sections. This method is particularly widely used in renal pathology research, where it is commonly applied to examine morphological alterations of the glomerular capillary basement membrane, such as thickening, rupture, folding, double-contour (tram-track) appearance, or abnormal proliferation caused by inflammatory injury. In addition, this method can also be applied to the histological investigation and morphological observation of glomerular diseases, diabetic nephropathy, and other basement membrane–associated pathological changes.

Cell Biology Cell Analysis Staining Kit

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HY-K1043A Polyamine Supplement (1000×)

MCE Polyamine Supplement (1000×) can be used as a component of the CEPT Cocktail in combination with Emricasan, Chroman 1, and trans-ISRIB to enhance the survival of pluripotent stem cells (PSCs) and promote single-cell clonal expansion. In addition, this supplement improves the viability of PSCs and their differentiated derivatives during cryopreservation, organoid culture, single-cell cloning, and genome editing, thereby enhancing the robustness and reproducibility of downstream applications.

Cell Biology Cell Culture CEPT cocktail

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Keywords

3D genome | cellular memory | chromatin architecture | topologically associating domains | CTCF | cohesin | enhancer-promoter interaction | epigenetic inheritance | nucleosome segregation | cell identity