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Tumor Cell Metabolites Regulate The Tumor Immune Microenvironment

Tumor Microenvironment Metabolic Diseases Cancer Immunotherapy Mitochondrial Dysfunction

Tumor cells do more than compete with immune cells for nutrients; they actively construct an immunosuppressive metabolic environment. Rapid glucose and amino-acid consumption, lactate export, extracellular adenosine production, lipid remodeling, and tryptophan catabolism can change the survival and function of T cells, natural killer cells, dendritic cells, macrophages, and myeloid-derived suppressor cells. These effects help explain why a tumor containing recognizable antigens can remain resistant to immune attack. Modern cancer immunometabolism therefore studies metabolites as intercellular signals and selective pressures, not merely by-products of growth. The field is moving from cataloguing metabolic differences toward identifying dependencies that can be blocked without disabling systemic immunity Tumor and immune cells also exchange metabolites through stromal and vascular compartments, making the niche a cooperative metabolic ecosystem rather than a tumor-only phenotype[1][2][3].

Cancer-cell glycolysis lowers glucose and acidifies tissue through lactate, impairing lymphocyte proliferation and cytokine production while favoring suppressive myeloid states. Hypoxia and mitochondrial stress reinforce these changes. ATP released in damaged tissue can be converted by CD39 and CD73 into adenosine, which signals through inhibitory receptors on immune cells. IDO1 and related pathways deplete tryptophan and generate immunoregulatory kynurenine. Tumor-derived lipids and altered fatty-acid handling can cause dysfunction in infiltrating lymphocytes or support macrophage and regulatory-cell programs. These pathways overlap: poor perfusion changes oxygen and nutrient gradients, and the resulting immune suppression permits further tumor metabolic adaptation Lactate and adenosine can simultaneously change intracellular signaling, chromatin, migration, and receptor expression, so their impact extends beyond simple energy deprivation[1][2].

Therapeutic applications include inhibitors of lactate production or transport, CD39–CD73–adenosine blockade, IDO-pathway intervention, and strategies that improve T-cell mitochondrial or nutrient fitness. Metabolic drugs may sensitize tumors to PD-1 blockade, adoptive cell therapy, radiation, or chemotherapy when the targeted pathway is a demonstrated resistance mechanism. Engineering CAR-T cells to use alternative fuels or resist adenosine is another approach. Systemic metabolic inhibition can affect liver, muscle, brain, hematopoiesis, and activated normal lymphocytes, so tumor selectivity and schedule matter. A pathway essential to cultured cancer cells may be redundant in vivo, where stromal cells and circulation provide alternative substrates Because activated lymphocytes share many biosynthetic requirements with cancer cells, an inhibitor can suppress the antitumor response at the same dose that slows malignant growth[1][2][3].

Key gaps include spatial resolution, causal validation, and patient selection. Bulk metabolomics can miss steep gradients between vessels, tumor nests, and necrotic regions, while metabolite abundance does not reveal which cell produced or consumed it. Stable-isotope tracing, spatial metabolomics, and single-cell transcriptional data should be integrated with functional immune assays. Trials need pharmacodynamic evidence that a drug changes the intended metabolite and restores immune activity in tissue. Dietary state, microbiome, organ function, and prior therapy can modify the same pathway. Metabolic therapy will be most effective when it targets a tumor-specific dependency and simultaneously preserves the energetic flexibility required for durable antitumor immunity Outcome studies should therefore relate metabolic target engagement to both tumor-cell viability and the number, state, and location of functional immune effectors. Combination dosing should follow the measured duration and compartment of metabolic suppression[1][2][3].

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Cat. No. Product Name Information Application Publication
HY-B0345A ATP disodium salt
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.

Source: Widespread

Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
175
HY-L084 Microbial Metabolite Library
Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine. MCE provides a unique collection of 939 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

Metabolism Focused Libraries Natural Product Screening Libraries

87
HY-L070 Neuroprotective Compound Library
Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases. MCE offers a unique collection of 1,851 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.

Compound Characteristic Classified Libraries

84
HY-L0107V Life Chemicals Natural Product-like Compound Library
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders. In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.
83
HY-L204 Lactic Acid Metabolic Compound Library
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 582 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
83
HY-L213 Anti-Cancer Approved Drug Library
The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies. This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment. MCE has collected 265 small-molecule compounds with cancer indications, which are good tools for drug repurposing.
83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L234 Nucleotide Metabolite Compound Library
Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs. MCE can provide 83 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.

Metabolism Focused Libraries

83
HY-L249 Lactylation Compound Library
Protein lactylation, an emerging post-translational modification identified in recent years, plays a critical role in linking cellular metabolic reprogramming, epigenetic regulation, and signaling networks. Based on a systematic framework encompassing lactate metabolism, lactylation, and downstream signaling pathways, this compound library comprehensively targets multiple regulatory layers, including histone modification enzymes (such as p300 and HDACs), key glycolytic enzymes (such as PKM2, LDHA, and GAPDH), transcriptional regulators (such as STAT3, HMGB1, and p53), as well as central signaling pathway nodes including HIF-1α, NF-κB, and PI3K-AKT-mTOR. This integrated design enables a comprehensive representation of the regulatory roles of lactylation across the “metabolism–epigenetics–signaling” axis. MCE has assembled a collection of 6,182 known bioactive compounds and potential functional molecules, making this library suitable for a wide range of applications, including high-throughput drug screening, inhibitor identification, and mechanistic studies. It can be used to systematically evaluate the functional roles of lactylation in biological processes such as tumor metabolism, immune regulation, and inflammatory responses, and to efficiently identify small-molecule candidates with regulatory potential, thereby facilitating the development of innovative therapeutics targeting the interplay between metabolism and epigenetic regulation.

Signaling Pathway Targeting Libraries

83
HY-L250 Lactic Acid Metabolite Compound Library
In the progression of various diseases, metabolic reprogramming has emerged as a key hallmark. Lactate, as an important metabolic signaling molecule, is widely involved in tumorigenesis, immune regulation, and inflammatory responses. Particularly within the tumor microenvironment, the abnormal accumulation of lactate not only affects cellular energy metabolism but also promotes disease progression by modulating immune cell functions and mediating protein lactylation, thereby participating in epigenetic regulation and signaling networks. Therefore, systematic investigation of lactate metabolic pathways and their associated metabolites is of great significance for understanding disease mechanisms and developing novel therapeutic strategies. The MCE lactic acid metabolite compound library contains 61 compounds and is constructed around key metabolic pathways involving lactate production, transport, and utilization. This library systematically includes core intermediates from glycolysis, the tricarboxylic acid (TCA) cycle, and the lactate cycle. Focusing on disease-associated metabolic reprogramming, it is suitable for research in oncology, inflammation, and metabolic disorders. The library can be used to elucidate the roles of lactate in tumor microenvironment regulation, immune evasion, and epigenetic modifications (such as protein lactylation). In addition, it provides high-quality small-molecule resources for drug screening, facilitating the discovery of potential modulators targeting key enzymes (such as LDH) or transporters (such as MCTs) involved in lactate metabolism.

Signaling Pathway Targeting Libraries

83
HY-L252 Carbohydrate Metabolite Compound Library
Carbohydrate metabolism serves as a central hub for energy supply and biosynthesis in living organisms and plays a critical role in the onset and progression of various diseases. In recent years, studies have shown that tumor cells reprogram their energy metabolism through aerobic glycolysis (the Warburg effect) to support rapid proliferation. Immune cells also rely on specific carbohydrate metabolic pathways to regulate their activation and differentiation states, while disorders such as diabetes and metabolic syndrome arise directly from dysregulation of carbohydrate metabolism. In addition, enzymes and key metabolic nodes involved in carbohydrate metabolism have become important targets for drug discovery, and therapeutic strategies targeting glycolysis, the pentose phosphate pathway, and energy metabolism are continuously advancing the treatment of cancer and metabolic diseases. Therefore, systematic analysis of carbohydrate metabolic networks and their associated metabolites is of great significance for elucidating disease mechanisms and developing novel therapeutic approaches. The MCE Carbohydrate Metabolism Metabolite Library is constructed based on classical carbohydrate metabolic pathways and contains 76 metabolites. It systematically integrates key metabolic networks, including glycolysis, the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle, monosaccharide metabolism, and sugar acid interconversions. The library comprehensively covers core metabolic nodes from glucose uptake and utilization to energy production and biosynthesis, while also incorporating important upstream and downstream intermediates. It enables accurate representation of intracellular metabolic flux dynamics and is well suited for applications such as metabolic flux analysis, target validation, and mechanistic studies. Furthermore, it provides robust support for multi-omics integration and the development of precision intervention strategies.
83
HY-L253 Fungal-Sourced Compound Library
For thousands of years, natural products have always been an important source for drug discovery. Fungi, due to their unique and diverse secondary metabolic capabilities, have become a valuable resource for natural active molecules. Since the discovery of penicillin, natural products derived from fungi have demonstrated significant application value in areas such as anti-infection, anti-tumor, immune regulation, and metabolic disease research. A large number of clinical drugs, such as antibiotics, immunosuppressants, and lipid-lowering drugs, are derived from fungal metabolites or their structurally optimized derivatives. MCE fungal-derived compound library contains 91 structurally diverse and bioactive fungal natural products and their derivatives. It can be widely applied in various research fields such as antibacterial, anti-tumor, anti-inflammatory, immune regulation, epigenetics, and cell signaling pathways, providing high-quality tools for natural product drug development and high-throughput screening.

Natural Product Screening Libraries

83
HY-L263 Energy Metabolites Library
Energy metabolism is the most fundamental biochemical process in living organisms, encompassing glycolysis, the TCA cycle, oxidative phosphorylation, the pentose phosphate pathway, and fatty acid oxidation. These core pathways directly regulate cell survival, proliferation, differentiation, and apoptosis. Dysregulation of energy metabolism is closely linked to major diseases including cancer, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders, and ischemia‑reperfusion injury. Targeting these metabolic pathways has become a frontier in drug discovery and mechanistic research. The MCE Energy Metabolite Compound Library features 89 structurally defined small‑molecule compounds. It covers energy substrates, pathway intermediates, coenzymes and redox carriers, nucleotide derivatives, and microenvironmental modulators. This library is applicable to research areas including tumor metabolism, insulin resistance, mitochondrial dysfunction, oxidative stress, neuroprotection, and cardiometabolic diseases, providing a high‑quality tool for mechanistic studies, biomarker discovery, and high‑throughput drug screening.

Signaling Pathway Targeting Libraries

83
HY-W013032 Oxamic acid
Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.

Source: Balanus nubilus Darwin

Lactate Dehydrogenase   Apoptosis  
Digestive System Disease   Digestive System Inflammation  
74
HY-W013032A Oxamic acid sodium
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.
Lactate Dehydrogenase   Apoptosis  
Cancer   Digestive System Disease   Digestive System Inflammation  
74
HY-15947 Ravoxertinib
Ravoxertinib (GDC-0994) is an orally active ERK1/2 inhibitor. Ravoxertinib inhibits the ERK1/2 MAPK signaling pathway and reduces the expression levels of c-Myc, HK2 and LDHA. Ravoxertinib decreases mammosphere formation, and exerts additive and/or superadditive cytotoxicity when combined with Ipatasertib (HY-15186) in 3D tumor sphere models. Ravoxertinib can be used in research related to various cancers including breast cancer, melanoma, head and neck cancer, non-small cell lung cancer, ovarian cancer and Merkel cell carcinoma.
ERK   Lactate Dehydrogenase   Hexokinase   c-Myc  
Colorectal Cancer   Pancreatic Cancer   Non-Small Cell Lung Cancer   Lung Adenocarcinoma  
52
HY-100681 GSK2837808A
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.
Lactate Dehydrogenase  
Cancer  
50
HY-16214 FX-11
FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts.
Lactate Dehydrogenase   Apoptosis   Reactive Oxygen Species (ROS)  
Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   Parkinson's Disease  
33
HY-B1511A Cyclic AMP sodium
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes.
Biochemical Assay Reagents  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
30
HY-B1511 Cyclic AMP
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
30
HY-N0171A Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
Bacterial   Apoptosis   Reactive Oxygen Species (ROS)   MDM-2/p53   Caspase   PARP   MMP   Bcl-2 Family   HIF/HIF Prolyl-Hydroxylase   TNF Receptor   Interleukin Related   NF-κB   mTOR   Lactate Dehydrogenase   CDK   Glutathione Peroxidase   SOD  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
25
HY-125286 AB-680
AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.
CD73  
Cancer  
24
HY-A0181A Adenosine 5'-monophosphate monohydrate
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2.
Endogenous Metabolite   Adenosine Receptor   HSV  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Viral Infection   SARS-CoV-2 Infection  
22
HY-W011012 Adenosine 5'-monophosphate disodium
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
Adenosine Receptor  
Metabolic or Endocrine Disease  
22
HY-A0181 Adenosine monophosphate
Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Endogenous Metabolite   Adenosine Receptor   HSV  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Viral Infection   SARS-CoV-2 Infection  
22
HY-B2227D Calcium 2-hydroxypropanoate pentahydrate
Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity.
Environmental Pollutants   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
20
HY-W010968 5'-Adenylic acid sodium hydrate
5'-Adenylic acid (sodium hydrate) (A-5'-P (sodium hydrate); AMP (sodium hydrate); Adenosine 5'-monophosphate (sodium hydrate)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Environmental Pollutants   Biochemical Assay Reagents  
20
HY-100742A (R)-GNE-140
(R)-GNE-140 is a potent inhibitor of lactate dehydrogenase (LDH) A, B and C, with IC50 values of 3, 5 and 5 nM against LDHA, LDHB, LDHC, respectively. (R)-GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. (R)-GNE-140 attenuates cardiac hypertrophy, alleviates PM2.5-induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression. (R)-GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer.
Lactate Dehydrogenase   Bacterial  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Breast Cancer   Bacterial Infection  
20
HY-W040118 Galloflavin
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 μM (LDH-A) and 15.06 μM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production.
Lactate Dehydrogenase  
Cancer  
19
HY-19533 SCH 58261
SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively.
Adenosine Receptor  
Lung Cancer   Parkinson's Disease  
18
HY-B0228 Adenosine
Adenosine (Adenine riboside), a ubiquitous and BBB-permeable endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Environmental Pollutants   Endogenous Metabolite   Nucleoside Antimetabolite/Analog   Autophagy   Apoptosis  
Metabolic or Endocrine Disease   Triple-Negative Breast Cancer  
18
HY-10888 Istradefylline
Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
Adenosine Receptor  
Cancer   Parkinson's Disease  
16
HY-19532 ZM241385
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.
Adenosine Receptor  
Cancer   Parkinson's Disease  
16
HY-N0092 Inosine
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
Adenosine Receptor   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Viral Infection   SARS-CoV-2 Infection   Lung Fibrosis  
16
HY-13201A CGS 21680 Hydrochloride
CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
Adenosine Receptor  
Cancer   Neurological, Eye or Ear Disease  
14
HY-B0809 Theophylline
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
Phosphodiesterase (PDE)   Adenosine Receptor   HDAC   Apoptosis   Interleukin Related   TNF Receptor   Endogenous Metabolite  
Breast Cancer   Colorectal Cancer   Cervical Cancer   Bladder Cancer   Depression   Digestive System Inflammation   Non-Small Cell Lung Cancer   Castration-Resistant Prostate Cancer   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Chronic Obstructive Pulmonary Disease   Asthma   Lung Fibrosis   Rheumatoid Arthritis  
14
HY-D0199 Adenosine 5'-diphosphate disodium
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.
Endogenous Metabolite  
Cardiovascular Disease  
10
HY-W010918 Adenosine 5'-diphosphate
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
Endogenous Metabolite  
10
HY-100937 DPCPX
DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes.
Adenosine Receptor  
Cancer   Cardiovascular Disease   Parkinson's Disease  
9
HY-147216 AXKO-0046
AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC50 value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism.
Lactate Dehydrogenase  
Cancer  
8
HY-103173 5'-N-Ethylcarboxamidoadenosine
5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.
Adenosine Receptor  
Cancer   Glucose Metabolism  
8
HY-P2764 Apyrase
Apyrase is an Nucleoside triphosphate diphosphohydrolase (NTPDase). Apyrase can hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP). Apyrase can inhibit Stx2 toxin release of enterohemorrhagic Escherichia coli (EHEC) infection and protect the intestinal barrier function. Apyrase can be used for the research of infection and inflammation, such as hemorrhagic colitis.
NTPDase  
Digestive System Disease   Colitis  
6
HY-100747 PSB-12379
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
CD73  
Cancer  
5
HY-103265D ARL67156 triethylamine
ARL67156 (FPL 67156) triethylamine is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 triethylamine is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 triethylamine can be used in the research of disease like calcific aortic valve disease, asthma.
NTPDase  
Inflammation or Immune System Disease   Cardiovascular Disease  
4
HY-103265B ARL67156 trisodium hydrate
ARL67156 (FPL 67156) trisodium hydrate is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium hydrate is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 trisodium hydrate can be used in the research of disease like calcific aortic valve disease, asthma.
NTPDase  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-103265 ARL67156 trisodium
ARL67156 (FPL 67156) trisodium is a selective small molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12?μM, respectively. ARL67156 trisodium can be used in the research of calcific aortic valve disease, asthma.
NTPDase  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-W008253 5-Hydroxyindole-3-acetic acid
5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
4
HY-Y0520 Itaconic acid
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect.
Endogenous Metabolite   Ferroptosis  
Cancer   Inflammation or Immune System Disease  
4
HY-B1180 Vinburnine
Vinburnine ((-)-Eburnamonine; (-)-Vincamone) is an orally active, blood-brain barrier permeable immunomodulator and apoptosis inducer. Vinburnine drives the secretion of IL-24 by activating the P38/MAPK/ATF3 signaling axis. Vinburnine induces reactive oxygen species production and DNA damage in cancer cells, thereby inhibiting cancer cell proliferation, activating the apoptotic cascade, and enhancing CD8+ T cell function to remodel the tumor immune microenvironment. Vinburnine can be used in the research of diseases such as melanoma.
Apoptosis   p38 MAPK  
Melanoma  
3
HY-B0153A Ticlopidine hydrochloride
Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
NTPDase   Cytochrome P450  
Cancer   Cardiovascular Disease   Parkinson's Disease  
3
HY-113486 Lathosterol
Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury[1].
Endogenous Metabolite   SOD   Lactate Dehydrogenase  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
3
HY-100386 Ticlopidine
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
NTPDase   Cytochrome P450  
Cardiovascular Disease  
3
HY-125850 Berberrubine chloride
Berberrubine chloride is an orally active metabolite of berberine. Berberrubine chloride alleviates mucosal lesions and inflammation in mouse colitis models. Berberrubine chloride has anti-inflammatory, anti-tumor, and antiviral activities.
Drug Metabolite   HIV   Interleukin Related  
Cancer   Digestive System Disease   Viral Infection   Digestive System Inflammation  
3
HY-N0797 (20S)-Protopanaxadiol
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells.
P-glycoprotein   Reactive Oxygen Species (ROS)   Apoptosis  
Digestive System Disease   Ovarian Cancer   Digestive System Inflammation  
3
HY-W010936 Nitrobenzylthioinosine
Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier.
Adenosine Receptor  
Cancer   Neurological, Eye or Ear Disease   Lung Fibrosis  
3
HY-75954 2-Hydroxyhexanoic acid
2-Hydroxyhexanoic acid is a metabolite. 2-Hydroxyhexanoic acid is elevated in metastatic pancreatic neuroendocrine tumors. 2-Hydroxyhexanoic acid does not promote the proliferation, migration or invasion of pancreatic neuroendocrine tumor cells. 2-Hydroxyhexanoic acid can be used in the research of metastatic pancreatic neuroendocrine tumors.
Endogenous Metabolite  
Cancer  
2
HY-W005288 4-Vinylphenol (10% in Propylene glycol)
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.

Source: recombinant Streptomyces mobaraense

Apoptosis   Endogenous Metabolite  
2
HY-N6985 Baccatin III
Baccatin III is an orally available, selective inhibitor of the TGF-β1 signaling pathway and myeloid-derived suppressor cell (MDSC) activation. Baccatin III targets the AKT/STAT6 and Smad2/3 pathways, blocking TGF-β1-induced fibroblast differentiation and MDSC-mediated immunosuppression. Baccatin III exerts anti-inflammatory and anti-fibrotic effects by inhibiting macrophage activation and extracellular matrix deposition, and shows potential in the treatment of pulmonary fibrosis and cancer in terms of regulating the tumor immune microenvironment.
Others  
Breast Cancer   Lung Fibrosis  
2
HY-W001171 3-Hydroxyanthranilic acid
3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.3-hydroxyanthranilic acid has anti-inflammatory, neuroprotective, and lipid-lowering effects. 3-hydroxyanthranilic acid can be used for researches of cardiovascular diseases, tumors, and metabolic diseases.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Cardiovascular Disease  
2
HY-P80223 METTL3 Antibody (YA294)
METTL3 Antibody (YA294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to METTL3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

2
HY-P1181 Pam2CSK4
Pam2CSK4 is a TLR2 agonist. Pam2CSK4 induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis.
Toll-like Receptor (TLR)   NO Synthase   IKK   Akt   PKC   NF-κB   p38 MAPK   Interleukin Related  
Leukemia/Lymphoma/Myeloma   Cancer Immunology   Immunotherapy for Melanoma   Influenza Virus Infection   Atherosclerosis and Inflammation   Heart Failure  
1
HY-145334 CD73-IN-5
CD73-IN-5 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (IC50 = 19 nM).
CD73  
Cancer  
1
HY-16467 Squalamine lactate
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

Source: Squalus acanthias

Bacterial  
Cancer   Infection   Blood or Cardio-cerebrovascular Disease  
1
HY-Y0479AS2 L-Lactate-13C sodium (20% in water)
L-Lactate-13C ((S)-2-Hydroxypropanoic acid-13C) sodium is the 13C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity.
Isotope-Labeled Compounds   Bacterial   Antibiotic   Drug Intermediate   Endogenous Metabolite  
Cancer   Infection  
1
HY-D0976 NF279
NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4, CCR5, CXCR3, and CXCR7-mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection.
P2X Receptor   HIV   NTPDase   CXCR  
HIV-1 Infection  
1
HY-P99039 Oleclumab
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.

Species: Human

CD73  
Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
1
HY-P1181A Pam2CSK4 TFA
Pam2CSK4 TFA is a TLR2 agonist. Pam2CSK4 TFA induces the expression of iNOS and NO in macrophage cell lines via TBK1 and MyD88 molecules. Pam2CSK4 TFA activates the NF-κB and Bruton's tyrosine kinase signaling pathways in platelets, and promotes platelet-endothelial cell interactions. TLR2 activation triggered by Pam2CSK4 TFA expands myeloid-derived suppressor cells (MDSCs) and suppresses anti-tumor immune responses in the tumor microenvironment. Pam2CSK4 TFA acts as a Th2-polarizing adjuvant in mouse vaccine models against Leishmania major and Brugia malayi. Pam2CSK4 TFA can be used in the research of various diseases, including thromboinflammatory diseases, sepsis, atherosclerosis, heart failure, influenza, lymphoma, melanoma, cutaneous leishmaniasis and lymphatic filariasis.
Toll-like Receptor (TLR)   NO Synthase   IKK   Akt   PKC   NF-κB   p38 MAPK   Interleukin Related  
Leukemia/Lymphoma/Myeloma   Cancer Immunology   Immunotherapy for Melanoma   Influenza Virus Infection   Atherosclerosis and Inflammation   Heart Failure  
1
HY-Y0479AS L-Lactic acid-13C3 sodium (20% w/w in water)
L-Lactic acid-13C3 ((S)-2-hydroxypropanoic-13C3) sodium (20% in water) is the 13C labeled L-Lactic acid. L-Lactic acid-13C3 sodium (20% in water) can be used for lactate metabolism research.
Antibiotic   Isotope-Labeled Compounds   Bacterial   Endogenous Metabolite  
Cancer   Infection   Metabolic or Endocrine Disease  
1
HY-P99144A Anti-Mouse PD-1 Antibody (S-5001)
Anti-Mouse PD-1 Antibody (S-5001) is a selective inhibitor targeting PD-1, blocking the PD-1/PD-L1 immune checkpoint axis through competitive binding to PD-1. Anti-Mouse PD-1 Antibody (S-5001) works by reversing the tumor immunosuppressive microenvironment and reactivating the anti-tumor activity of cytotoxic T lymphocytes. It can be used in research on tumors such as melanoma and HPV-positive oropharyngeal squamous cell carcinoma. Anti-Mouse PD-1 Antibody (S-5001) is often combined with photothermal therapy, chemotherapy, etc., to enhance efficacy.

Species: Mouse

PD-1/PD-L1  
Cancer Immunology   Immunotherapy for Melanoma   Squamous Cell Carcinoma  
1
HY-W015273A trans-3-Indoleacrylic acid
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis
Endogenous Metabolite   Ferroptosis  
Metabolic or Endocrine Disease   Colorectal Cancer  
1
HY-Y0479S L-Lactic acid-13C3
L-Lactic acid-13C3 is a 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid-13C3 can be used for lactate metabolism research.
Antibiotic   Isotope-Labeled Compounds   Bacterial   Endogenous Metabolite  
Cancer   Infection   Metabolic or Endocrine Disease  
1
HY-P70265 LDHB Protein, Human (His)
The LDHB protein, also known as lactate dehydrogenase B, is an enzyme that plays a crucial role in cellular energy metabolism. References indicate that the LDHB protein effectively catalyzes the simultaneous, stereospecific interconversion of pyruvate and lactate. LDHB Protein, Human (His) is the recombinant human-derived LDHB protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

1
HY-143959S Fingolimod Mono-lactate-d4 hydrochloride
Fingolimod Mono-lactate-d4 (hydrochloride) is the deuterium labeled Fingolimod Mono-lactate hydrochloride.
Isotope-Labeled Compounds  
/
HY-B1511G Cyclic AMP (GMP)
Cyclic AMP (GMP) (Cyclic adenosine monophosphate (GMP)) is Cyclic AMP (HY-B1511) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-W105639A Calcium L-lactate pentahydrate, meets USP testing specifications
Calcium L-lactate pentahydrate, meets USP testing specifications (Calcium lactate pentahydrate, meets USP testing specifications) is a biochemical reagent and serves as one of the important sources of calcium. Compared to other organic calcium salts, Calcium L-lactate pentahydrate, meets USP testing specifications exhibits excellent solubility and bioavailability. Calcium L-lactate pentahydrate, meets USP testing specifications possesses remarkable moisture resistance, thermal stability, and chemical stability and can be used in medical implants and drug delivery systems .
Biochemical Assay Reagents  
/
HY-W016773S 1,10-Decanediol-d20
1,10-Decanediol-d20 is the deuterium labeled 1,10-Decanediol. 1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism. can be used as a surfactant/stabilizer in the synthesis of nanomaterials.
Isotope-Labeled Compounds  
/
HY-155902D Mal-PEG10000-OH
Mal-PEG10000-OH (Maleimide-PEG10000-Hydroxy) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG10000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems.
Biochemical Assay Reagents  
/
HY-N6776R Penitrem A (Standard)
Prenylamine (lactate) (Standard) is the analytical standard of Prenylamine (lactate). This product is intended for research and analytical applications. Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588). Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents.
Reference Standards   Potassium Channel  
Cancer   Neurological, Eye or Ear Disease  
/
HY-136450S Triclabendazole sulfoxide-d3
Triclabendazole sulfoxide-d3 is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is an orally active ABCG2 inhibitor with antiparasitic activity. Triclabendazole sulfoxide inhibits ABCG2-mediated active efflux and ATPase activity. Triclabendazole sulfoxide increases the intracellular accumulation of Mitoxantrone (HY-13502). Triclabendazole sulfoxide reduces the apical-directed transepithelial transport of Nitrofurantoin and Danofloxacin, while increasing their basolateral-directed transepithelial transport. Triclabendazole sulfoxide elevates the plasma levels of sulfasalazine in wild-type mice. Triclabendazole sulfoxide decreases ABCG2-mediated secretion of Nitrofurantoin into milk in wild-type lactating mice. Triclabendazole sulfoxide can be used in the research of insecticidal agents and cancers such as breast cancer.
Isotope-Labeled Compounds   Parasite   BCRP  
Infection  
/
HY-P992446 PUR001
PUR001 is a monoclonal antibody targeting NTPDase 1 (CD39). PUR001 blocks the hydrolysis of extracellular ATP and ADP into AMP by inhibiting CD39, reduces the production of immunosuppressive adenosine, and increases extracellular ATP concentration to activate anti-tumor immune responses. PUR001 can be used in studies related to solid tumors.

Species: Human

NTPDase  
Cancer  
/
HY-137404 Adenosine 5'-O-thiomonophosphate dilithium
Adenosine 5'-O-thiomonophosphate dilithium is a compound that inhibits phosphohydrolase activity and can also serve as a substrate for 5'-nucleotidase.
Biochemical Assay Reagents  
/
HY-P992362 HBM1007
HBM1007 is a fully human monoclonal antibody targeting CD73. HBM1007 is an extracellular enzyme expressed on the surface of stromal cells and tumor cells, capable of converting extracellular adenosine monophosphate (AMP) into adenosine, and recognizing CD73 via a unique antigenic epitope. HBM1007 inhibits both CD73-dependent and CD73-independent enzyme activities.

Species: Human

CD73  
Cancer  
/
HY-120993 1,N6-Ethenoadenosine 5'-monophosphate sodium
1,N6-Ethenoadenosine 5'-monophosphate (1,N6-Etheno-AMP) sodium is a highly fluorescent analog of adenosine 5'-monophosphate (AMP). 1,N6-Ethenoadenosine 5'-monophosphate sodium is a powerful probe for systems involving adenosine 5'-monophosphate and can be detected at low concentration. 1,N6-Ethenoadenosine 5'-monophosphate sodium has long wavelength of excitation (250-300 nm), and emission at 415 nm.
Fluorescent Dye  
/
HY-W040073S Nifurtimox-d4
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
Isotope-Labeled Compounds   Parasite   Lactate Dehydrogenase  
Cancer   Infection  
/
HY-P992518 Pumitamig (Mouse IgG2a)
Pumitamig (Mouse IgG2a) is the Mouse IgG2a control antibody for Pumitamig (HY-P991097). Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy.
VEGFR   PD-1/PD-L1  
Ovarian Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
/
HY-P990038 Eurestobart
Eurestobart (ES002023) is a recombinant human IgG1 antibody against CD39. Eurestobart restores antitumor immunity by stabilizing the pro-inflammatory extracellular ATP (eATP) and interfering with synthesis of the immunosuppressive adenosine within the tumor microenvironment (TME). Eurestobart is used in the research of locally advanced and metastatic solid tumors.

Species: Human

NTPDase  
Neurological, Eye or Ear Disease  
/
HY-B1505G Acefylline (GMP)
Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research.
Adenosine Receptor   Protein Arginine Deiminase   Phosphodiesterase (PDE)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-155902E Mal-PEG20000-OH
Mal-PEG20000-OH (Maleimide-PEG20000-Hydroxy) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG20000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems.
Biochemical Assay Reagents  
/
HY-P10759 DTS-201 sodium
DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer.
Peptide-Drug Conjugates (PDCs)   Aminopeptidase  
/
HY-D1186 2-Aza-ε-adenosine
2-Aza-ε-adenosine (2-Aza-1,N6-ethenoadenosine) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
Fluorescent Dye  
/
HY-W250153A Adenosine 3'-phosphate 5'-phosphosulfate lithium, hydrate
Adenosine 3'-phosphate 5'-phosphosulfate lithium hydrate, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate lithium hydrate can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate lithium hydrate is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium hydrate can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group.
P2Y Receptor  
Platelet Disease  
/
HY-W008449S 1-Methylxanthine-13C,d3
1-Methylxanthine-13C,d3 is the 13C- and deuterium labeled 1-Methylxanthine. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-W008253S3 5-Hydroxyindole-3-acetic acid-13C6
5-Hydroxyindole-3-acetic acid-13C6 is the 13C-labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P5708 Adenoregulin
Adenoregulin (Dermaseptin b2) is an antimicrobial peptide antibiotic. Adenoregulin is active against Gram-negative and Gram-positive bacteria, yeast and fungi. Adenoregulin also enhances the binding of agonists to the A1 adenosine receptor.

Source: frog

Antibiotic   Bacterial   Fungal  
Infection  
/
HY-W011012R Adenosine 5'-monophosphate disodium (Standard)
Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
Reference Standards   Adenosine Receptor  
Metabolic or Endocrine Disease  
/
HY-W769991 Lactate sodium-13C2
Lactic acid-13C2 (DL-Lactic acid-13C2) sodium is the 13C-labeled Lactic acid sodium . Lactic acid (DL-Lactic acid) sodium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid sodium also has antimicrobial activity, which can be used as a food preservative.
Isotope-Labeled Compounds   Bacterial   Hydroxycarboxylic Acid Receptor (HCAR)   Endogenous Metabolite  
Cancer  
/
HY-112175R N-Acetylhistamine (Standard)
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.
Reference Standards   Histamine Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Staphylococcus Aureus Infection  
/
HY-105129AS Pimonidazole-d10
Pimonidazole-d10 is the deuterium labeled Pimonidazole. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
Isotope-Labeled Compounds  
/
HY-P991634 IBI-325
IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research.

Species: Human

CD73   TNF Receptor   Interleukin Related   IFNAR  
Cancer   Inflammation or Immune System Disease  
/
HY-N20238 Chinese gallnut extract
Chinese gallnut extract is an extract of the gallnut (Melaphis chinensis gallnut) and is an inhibitor of human lactate dehydrogenase (LDH)-A.
Lactate Dehydrogenase  
/
HY-P991403 BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. BC011 promotes CD8+T cell proliferation and depletes Treg cells, thereby increasing the proportion of effector T cells in the tumor microenvironment. BC011 can be used in tumor Immunity research.

Species: Human

TNF Receptor  
Cancer  
/
HY-155902C Mal-PEG3400-OH
Mal-PEG3400-OH (Maleimide-PEG3400-Hydroxy) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG3400-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems.
Biochemical Assay Reagents  
/
HY-P991309 ZM-008
ZM-008 is an anti-LLT1 monoclonal antibody. ZM-008 blocks the interaction between LLT1 and CD161 on the surface of NK cells and T cells. ZM-008 restores anti-tumor immune activity, shifts the tumor microenvironment to an immune-responsive state, and recovers NK cell-mediated cytotoxicity against tumor cells, thereby reversing immunosuppression in immune-resistant "cold" tumors. ZM-008 is applicable to the research of immune-resistant solid tumors.

Species: Human

C-type Lectin-like Receptors (CTLRs)  
Cancer  
/
HY-59208R 4-Quinolinol (Standard)
4-Quinolinol (Standard) is the analytical standard of 4-Quinolinol. This product is intended for research and analytical applications. 4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune.
Endogenous Metabolite   Reference Standards  
Cancer   Neurological, Eye or Ear Disease  
/
HY-W250153 Adenosine 3'-phosphate 5'-phosphosulfate lithium
Adenosine 3'-phosphate 5'-phosphosulfate lithium, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate lithium can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group.
P2Y Receptor  
Platelet Disease  
/
HY-141466 Crotonyl-CoA
Crotonyl-CoA, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA can be used for the research of LPS-induced inflammatory response.
Endogenous Metabolite   Histone Acetyltransferase  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-141465 3-Hydroxybutyryl-CoA
3-Hydroxybutyryl-CoA is a metabolite which can be found in mouse or E.coli, et al. 3-Hydroxybutyryl-CoA has a 3-hydroxybutanoyl as the S-acyl component, and is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-Y0496S 1,4-Dichlorobenzene-d4
1,4-Dichlorobenzene-d4 is the deuterium labeled 1,4-Dichlorobenzene. 1,4-Dichlorobenzene is a non-genotoxic, orally active mitogenic/tumor-promoting carcinogen that is also widely used as a dye, resin intermediate, and deodorant, moth repellent/insecticide. 1,4-Dichlorobenzene induces liver tumors in mice and promotes the growth of spontaneous precancerous lesions, but shows no liver tumor-inducing activity in F344 rats. 1,4-Dichlorobenzene increases the levels of white blood cell count, serum alanine aminotransferase and blood urea nitrogen in occupationally exposed populations. 1,4-Dichlorobenzene is metabolized to 2,5-dichlorophenol and excreted in urine, and this metabolite can serve as a biomarker for 1,4-Dichlorobenzene exposure. Due to its specific hepatotoxic characteristics, 1,4-Dichlorobenzene is applicable to liver cancer-related research.
Isotope-Labeled Compounds   Insecticide  
/
HY-W001542R 5-Hydroxyoxindole (Standard)
5-Hydroxyoxindole is a structural analog of uric acid for its antioxidant. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole is a product of partial metabolism of tryptophan involving conversion in the gut lumen of tryptophan to indole through the action of bacterial tryptophanase and tryptophan synthase. 5-Hydroxyoxindole is one of the main molecules responsible for the neurological symptoms of hepatic encephalopathy in rats. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders.
Reference Standards   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B1180R Vinburnine (Standard)
Vinburnine ((-)-Eburnamonine; (-)-Vincamone) (Standard) is the analytical standard of Vinburnine (HY-B1180). This product is intended for research and analytical applications. Vinburnine ((-)-Eburnamonine; (-)-Vincamone) phosphate is an orally active, blood-brain barrier permeable immunomodulator and apoptosis inducer. Vinburnine drives the secretion of IL-24 by activating the P38/MAPK/ATF3 signaling axis. Vinburnine induces reactive oxygen species production and DNA damage in cancer cells, thereby inhibiting cancer cell proliferation, activating the apoptotic cascade, and enhancing CD8+ T cell function to remodel the tumor immune microenvironment. Vinburnine can be used in the research of diseases such as melanoma.
Reference Standards   Apoptosis   p38 MAPK  
Melanoma  
/
HY-N11627 L-Indole-3-lactic acid
L-Indole-3-lactic acid is an L (-)-tryptophan metabolite found in strains of Bifidobacterium, Lactobacillus plantarum and Lactobacillus paraplantarum, and also an indole-based antioxidant. L-Indole-3-lactic acid is produced via the pathway that converts tryptophan into indole-3-pyruvic acid. L-Indole-3-lactic acid acts as a free radical scavenger to eliminate DPPH free radicals. L-Indole-3-lactic acid can be used in antioxidant and metabolism-related research.

Source: Bifidobacterium spp

Endogenous Metabolite  
Metabolic or Endocrine Disease   Antioxidant Agent  
/
HY-N6935R Sennidin B (Standard)
Sennidin B Standard is the analytical standard of Sennidin B (HY-N6935). This product is intended for research and analytical applications. Sennidin B is an anthraquinone compound isolated from Cassia angustifolia. Sennidin B is a DPP-4 inhibitor with an IC50 of 39.39 μM. Sennidin B is an insect chitinase inhibitor with a Ki of 80 nM against OfChi-h. Sennidin B competitively inhibits chitinase activity by forming π-π stacking interactions with key tryptophan residues in the active site through a folded conformation. Sennidin B activates PI3K/Akt to promote glucose uptake in adipocytes. Sennidin B can be used for the development of biopesticides and research on type 2 diabetes and metabolism-related signaling pathways.
Reference Standards   Insecticide   Dipeptidyl Peptidase   PI3K   Akt   Endogenous Metabolite  
Type 2 Diabetes  
/
HY-Y1322S Triphenyl phosphate-d15
Triphenyl phosphate-d15 is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.
JNK   Apoptosis   Isotope-Labeled Compounds   Indoleamine 2,3-Dioxygenase (IDO)   Akt   Reactive Oxygen Species (ROS)   PPAR   ERK   NF-κB   Mitophagy   PI3K   Environmental Pollutants   p38 MAPK   Monoamine Oxidase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Urogenital Disease  
/
HY-131485A 3-Acetylpyridine adenine dinucleotide, 95%
3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite.
Lactate Dehydrogenase  
Metabolic or Endocrine Disease  
/
HY-W040233S1 L-Lactic acid-2-d1 sodium
Sodium L-Lactate-2-d is the deuterium labeled Sodium L-Lactate-2.
Isotope-Labeled Compounds  
/
HY-P990324 Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5)
Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) is a humanized antibody expressed in CHO cells, targeting AA2AR/Adenosine A2aR. Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 146.66 kDa. The isotype control for Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Adenosine Receptor  
Inflammation or Immune System Disease  
/
HY-B0843AS Metalaxyl-M-d6
Metalaxyl-M-d6 ((R)-Metalaxyl-d6) is the deuterium labeled Metalaxyl-M (HY-B0843A). Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies.
Isotope-Labeled Compounds   DNA/RNA Synthesis   Fungal  
Infection   Inflammation or Immune System Disease  
/
HY-W005288S 4-Vinylphenol-d4
4-Vinylphenol-d4 is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.
Apoptosis   Endogenous Metabolite   Isotope-Labeled Compounds  
/
HY-N13295 Indole-3-lactate-O-β-D-glucopyranoside
Indole-3-lactate-O-β-D-glucopyranoside is an endogenous metabolite that acts as a plant growth regulator.
Plant Growth Regulators   Endogenous Metabolite  
/
HY-B0228S9 Adenosine-13C10,15N5
Adenosine-13C10,15N5 is the 13C and 15N labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Isotope-Labeled Compounds   Apoptosis   Nucleoside Antimetabolite/Analog   Autophagy   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-W076441 Ethyl (S)-3-hydroxybutanoate
Ethyl (S)-3-hydroxybutanoate, also known as (S)-ethyl lactate, which is an ester formed by the condensation of ethanol and (S)-3-hydroxybutanoate, is known for its fruity, sweet smell and taste , which are commonly used as flavoring agents and fragrances in the food and cosmetic industries, and in addition, its potential use as a starting material for the synthesis of various organic compounds, including pharmaceuticals and agrochemicals, has been investigated.
Biochemical Assay Reagents  
/
HY-W038795 (S)-Ethyl lactate
(S)-Ethyl lactate ((S)-(-)-ethyl lactate) is a volatile compound produced by plant fermentation. (S)-Ethyl lactate cansynergistically attracts palm weevils with specific pheromones and is mainly used for pest monitoring and control research.
Environmental Pollutants  
/
HY-176785S MCB-294
MCB-294 is a dual-state pan-KRAS inhibitor that selectively inhibits KRAS over NRAS and HRAS. MCB-294 capable of binding both the active (GTP-bound) and inactive (GDP-bound) forms of KRAS with Kds of approximately 1 pM and 10 nM, respectively. MCB-294 broadly impairs the growth of hTERT-HPNE cells expressing G12D, G12C, G12V, G12S, G13D, and wild-type KRAS, with IC50s of approximately 700 nM. MCB-294 induces irreversible apoptosis in KRAS-mutated tumors. MCB-294 effectively suppress KRASG12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-294 can be used for the study of pancreatic cancer, colorectal cancer and lung cancer.
Ras   Apoptosis   p38 MAPK   Caspase   TNF Receptor  
/
HY-103695 CD73-IN-1
CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80.
CD73  
Cancer  
/
HY-N14001 Naamidine J
Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors.

Source: Pericharax heteroraphis

TNF Receptor   Interleukin Related   Arginase   PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease  
/
HY-P990704 Rilvegostomig
Rilvegostomig (AZD-2936) is a bispecific humanized IgG1 antibody targeting PD-1 and TIGIT. Rilvegostomig induces tumor growth inhibition and modulates the tumor immune microenvironment. Rilvegostomig exhibits anti-tumor activity in metastatic non-small cell lung cancer (without prior immune checkpoint inhibitor treatment). Rilvegostomig can be used in research related to metastatic non-small cell lung cancer and endometrial cancer.

Species: Human

PD-1/PD-L1   Transmembrane Glycoprotein  
Non-Small Cell Lung Cancer   Endometrial Cancer  
/
HY-D2361 Adenosine 2'-PEG-Biotin
Adenosine 2'-PEG-Biotin is a biochemical reagent derived from adenosine. Adenosine 2'-PEG-Biotin regulates cell signaling pathways by mimicking the effects of endogenous adenosine and binding to its receptors. Adenosine 2'-PEG-Biotin can be used in the research of bioprobes, biosensors and diagnostic reagents.
Nucleoside Antimetabolite/Analog  
/
HY-B0228S4 Adenosine-1′-13C
Adenosine-1′-13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
Isotope-Labeled Compounds   Apoptosis   Nucleoside Antimetabolite/Analog   Endogenous Metabolite   Autophagy  
Cancer   Metabolic or Endocrine Disease  
/
HY-P10449 M2 Peptide
M2 Peptide is a peptide targeting M2-like tumor-associated macrophages (TAMs). M2 Peptide is used to carry drugs or small interfering RNA (siRNA) to promote the repolarization of M2-like macrophages to M1-like macrophages, thereby altering the immunosuppressive state in the tumor microenvironment and enhancing the anti-tumor immune response. M2 Peptide can be used to study the effect of macrophage polarization and how this polarization change affects tumor growth and metastasis.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-120566 PSB-16131
PSB-16131 is a potent inhibitor of human NTPDase2, showing non-competitive inhibition with an IC50 of 539 nM. PSB-16131 can be used in the study of inflammation, neurodegenerative diseases and cancer.
NTPDase  
Cancer   Inflammation or Immune System Disease   Neurodegenerative Disease  
/
HY-G0017S N-Desmethyl imatinib-d8
N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib (HY-G0017). N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia.
Isotope-Labeled Compounds   Drug Metabolite   P-glycoprotein   Apoptosis  
Cancer   Parkinson's Disease  
/
HY-N2498 Glomeratose A
Glomeratose A is a lactate dehydrogenase inhibitor, isolated from Polygala tenuifolia.
Lactate Dehydrogenase  
/
HY-103263 PSB-06126
PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM.
NTPDase  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Cardiovascular Disease  
/
HY-D0199R Adenosine 5'-diphosphate disodium (Standard)
Adenosine 5'-diphosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-diphosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.
Endogenous Metabolite   Reference Standards  
Blood or Cardio-cerebrovascular Disease  
/
HY-113098R 2-Oxovaleric acid (Standard)
2-Oxovaleric acid (Standard) is the analytical standard of 2-Oxovaleric acid (HY-113098). This product is intended for research and analytical applications. 2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase from Phycomyces blakesleeanus.
Reference Standards   Lactate Dehydrogenase   Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-W001542 5-Hydroxyoxindole
5-Hydroxyoxindole is a structural analog of uric acid for its antioxidant. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole is a product of partial metabolism of tryptophan involving conversion in the gut lumen of tryptophan to indole through the action of bacterial tryptophanase and tryptophan synthase. 5-Hydroxyoxindole is one of the main molecules responsible for the neurological symptoms of hepatic encephalopathy in rats. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders.
Free Radical Scavengers   Reactive Oxygen Species (ROS)  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection   Parkinson's Disease  
/
HY-W011398 Linoleate sodium
Linoleate sodium is an orally active IL8 regulator via the JNK and NF-κB pathway. Linoleate sodium can change the composition of fatty acids and the production of metabolites in cells. Linoleate sodium has anti-inflammatory, immune-regulating, and tumor cell growth-affecting activities.
Environmental Pollutants   Parasite   Apoptosis   NF-κB   Interleukin Related   JNK  
Metabolic or Endocrine Disease   Pancreatic Cancer   Pain   Digestive System Inflammation  
/
HY-P4520 (Trp4)-Kemptide
(Trp4)-Kemptide is a peptide substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase.
Amino Acid Derivatives  
/
HY-N6935 Sennidin B
Sennidin B is an anthraquinone compound isolated from Cassia angustifolia. Sennidin B is a DPP-4 inhibitor with an IC50 of 39.39 μM. Sennidin B is an insect chitinase inhibitor with a Ki of 80 nM against OfChi-h. Sennidin B competitively inhibits chitinase activity by forming π-π stacking interactions with key tryptophan residues in the active site through a folded conformation. Sennidin B activates PI3K/Akt to promote glucose uptake in adipocytes. Sennidin B can be used for the development of biopesticides and research on type 2 diabetes and metabolism-related signaling pathways.
Insecticide   Dipeptidyl Peptidase   PI3K   Akt   Endogenous Metabolite  
Type 2 Diabetes  
/
HY-B2227BS Lactic acid-d4 sodium (60% w/w in water)
Lactic acid-d4 (DL-Lactic acid-d4) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative.
Isotope-Labeled Compounds   Bacterial   Hydroxycarboxylic Acid Receptor (HCAR)   Endogenous Metabolite  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D0808 Meldola blue
Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.
Fluorescent Dye  
/
HY-P990263 Anti-Mouse CD73 Antibody (TY/23)
Anti-Mouse CD73 Antibody (TY/23) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD73. Anti-Mouse CD73 Antibody (TY/23) can neutralize CD73. Anti-Mouse CD73 Antibody (TY/23) can be used for the researches of cancer, infection and immunology, such as B16F10 tumor and murine cytomegalovirus infection.

Species: Mouse

CD73  
Cancer   Inflammation or Immune System Disease   Cytomegalovirus Infection  
/
HY-W008253S2 5-Hydroxyindole-3-acetic acid-d5
5-Hydroxyindole-3-acetic acid-d5 is the deuterium labeled 5-Hydroxyindole-3-acetic acid (HY-W008253). 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-B2227BS3 L-Lactic acid-13C-1 sodium (20% w/w in water)
L-Lactic acid-13C1 (L-E-270-13C1) sodium (20% in water) is the 13C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activityy.
Isotope-Labeled Compounds   Drug Intermediate   Bacterial   Endogenous Metabolite  
Cancer   Infection  
/
HY-112502 MethADP
MethADP is a specific CD73 inhibitor.
CD73  
Cancer  
/
HY-W008253S1 5-Hydroxyindole-3-acetic acid-d6
5-Hydroxyindole-3-acetic acid-d6 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
/
HY-150770S Adenosine 5'-triphosphate(ATP)-d4 ammonium solution (100 mM)
Adenosine 5'-triphosphate(ATP)-d4 (ammonium salt) is the deuterium labeled Adenosine 5'-triphosphate(ATP) ammonium salt.
Isotope-Labeled Compounds  
/
HY-W008253S 5-Hydroxyindole-3-acetic acid-d2
5-Hydroxyindole-3-acetic acid-d2 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P99181 Mupadolimab
Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73POS B cells.

Species: Human

CD73  
Inflammation or Immune System Disease   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   SARS-CoV-2 Infection  
/
HY-P99169 Uliledlimab
Uliledlimab is a potent against CD73 humanizedized monoclonal antibody. Uliledlimab inhibits the conversion of extracellular adenosine monophosphate (AMP) to adenosine. Uliledlimab can be used in research of cancer.

Species: Human

CD73  
Triple-Negative Breast Cancer  
/
HY-59208 4-Quinolinol
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
/
HY-W010918S2 Adenosine 5'-diphosphate-15N5 dilithium
Adenosine 5'-diphosphate-15N5 (Adenosine diphosphate-15N5 dilithium) dilithium is 15N labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
Isotope-Labeled Compounds   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990068 Perenostobart
Perenostobart (SRF617) is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC50 values of 1.9 nM (HEK293 OE cells), 0.7 nM (MOLP-8 cells), and 1.2 nM (RBC-lysed whole blood). Perenostobart enhances CD4+ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer.

Species: Human

NTPDase  
Cancer   Inflammation or Immune System Disease  
/
HY-185057 S-D-Lactoylglutathione
S-D-Lactoylglutathione (S-Lactylglutathione; (R)-S-Lactoylglutathione) is a multifunctional metabolic intermediate of the glyoxalase system. S-D-Lactoylglutathione activates K+ efflux in bacteria by displacing inhibitory glutathione from KefGB channels, thereby acidifying the cytoplasm. In eukaryotic cells, S-D-Lactoylglutathione mediates S-glutathionylation as a substrate of glyoxalase 2. S-D-Lactoylglutathione serves as a sensitive metabolic biomarker for neodymium nitrate neurotoxicity; when used in combination with MSCs-exo, it upregulates glutathione levels, downregulates lactate dehydrogenase and Glo2 levels, and inhibits cellular inflammatory responses and pyroptosis. S-D-Lactoylglutathione can be used in research related to prostate cancer, breast cancer, non-small cell lung cancer, sepsis-associated encephalopathy, and neurotoxicity.
Glyoxalase (GLO)   Endogenous Metabolite   Potassium Channel  
Breast Cancer   Prostate Cancer   Non-Small Cell Lung Cancer   Neurotoxic Agent  
/
HY-P990651 PY314
PY314 is a humanized antibody targeting TREM2. PY314 binds TREM2 on tumor-associated macrophages, depletes TREM2-high tumor-associated macrophages, reduces pro-tumorigenic M2 macrophage infiltration, increases CD8+ T cell, NK cell, and M1 macrophage infiltration, creates a proinflammatory tumor microenvironment, and promotes antitumor immune responseS. PY314 can be used for the research of platinum-resistant ovarian cancer, advanced solid tumors, breast cancer, and advanced refractory solid tumors.

Species: Human

TREM receptor  
Ovarian Cancer   Lung Adenocarcinoma   Triple-Negative Breast Cancer  
/
HY-P990961 Palverafusp alfa
Palverafusp alfa (IMM-2510; SYN-2510) is a PD-L1/VEGF-targeting IgG1κ type humanized antibody. Palverafusp alfa blocks PD-1/PD-L1 binding, relieves immune suppression, mediates PD-L1-directed antibody-dependent cellular cytotoxicity (ADCC). Palverafusp alfa blocks VEGF/VEGFR binding, inhibits angiogenic signaling, relieves VEGF-induced immune suppression. Palverafusp alfa reduces endothelial cell proliferation, enhances ADCC and antibody-dependent cellular phagocytosis (ADCP), inhibits tumor growth, reverses T cell immune suppression. Palverafusp alfa exhibits immune stimulatory, antiangiogenic, and anti-tumor activity in the tumor microenvironment. Palverafusp alfa can be used for the research of cancer, such as solid tumors, non-small cell lung cancer.

Species: Human

VEGFR   PD-1/PD-L1  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W039898 α-D-Mannose pentaacetate
α-D-Mannose pentaacetate (1,2,3,4,6-Penta-O-acetyl-α-D-mannopyranose) acts as a lactate promoter. It increases lactate production in rat red blood cells.
Biochemical Assay Reagents   Lactate Dehydrogenase  
Metabolic or Endocrine Disease  
/
HY-B0228S Adenosine-d1
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Isotope-Labeled Compounds   Nucleoside Antimetabolite/Analog   Autophagy   Apoptosis   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-W007328 5-Methoxyindole
5-Methoxyindole is an L-tryptophan metabolite with antifungal activity, and also serves as a pharmaceutical intermediate. Metabolites of 5-Methoxyindole exhibit COX-2 inhibitory, anti-inflammatory and anti-tumor activities. 5-Methoxyindole induces morphological distortion of hyphae and conidia, ROS accumulation, apoptosis and cell death in Gaeumannomyces graminis. 5-Methoxyindole can be used in studies related to fungal infections and organic synthesis.
Endogenous Metabolite   Drug Intermediate   Fungal   Reactive Oxygen Species (ROS)   Apoptosis  
Cancer   Inflammation or Immune System Disease   Fungal Infection  
/
HY-P4823 pTH (1-37) (human)
PTH (1-37) human is an adenylate cyclase stimulator and a normocalcemic regulator. PTH (1-37) human participates in cAMP-dependent signal transduction to affect the proliferation of skeletal tissue cells and bone metabolism. PTH (1-37) human induces cyclic adenosine monophosphate responses in human primary osteoblast-like cells and is also widely used in osteoporosis-related research.
Adenylate Cyclase   PTHR  
Osteoporosis  
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HY-Y1939A Metaphosphoric acid, 33.5-36.5%
Metaphosphoric acid, 33.5-36.5% (Glacial phosphoric acid, 33.5-36.5%) is a precipitant used for rapid enzymatic measurement of blood lactate and pyruvate. Metaphosphoric acid, 33.5-36.5% can also be used as a dehydrating agent, and its derivative sodium hexametaphosphate can be used as a chelating agent and food additive.
Biochemical Assay Reagents  
/
HY-B0228S11 Adenosine-15N5
Adenosine-15N5 (Adenine riboside-15N5; D-Adenosine-15N5) is the 15N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Isotope-Labeled Compounds  
Cancer  
/
HY-113221 Isovalerylcarnitine
Isovalerylcarnitine is a metabolite of leucine. Isovalerylcarnitine can specifically activate calpain in human neutrophils. Isovalerylcarnitine inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine are negatively correlated with reduced lung cancer risk.
Proteasome   Endogenous Metabolite   Apoptosis  
Cancer   Metabolic or Endocrine Disease  
/
HY-Y0520S Itaconic acid-13C5
Itaconic acid-13C5 is the 13C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.
Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-B0445GL NAD+ (GMP Like)
NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-113098 2-Oxovaleric acid
2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase from Phycomyces blakesleeanus.
Lactate Dehydrogenase   Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-107202GL Polyinosinic-polycytidylic acid (GMP Like)
Polyinosinic-polycytidylic acid (Poly(I:C)) (GMP Like) is the GMP Like class Polyinosinic-polycytidylic acid (HY-107202), and can be used as pharmaceutical excipients. Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Inflammation or Immune System Disease  
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HY-B0228S6 Adenosine-d2
Adenosine-d2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio
Apoptosis   Nucleoside Antimetabolite/Analog   Endogenous Metabolite   Autophagy  
Cancer   Metabolic or Endocrine Disease  
/
HY-124151 Adenosine-2'-monophosphate
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation.
Adenosine Receptor   Endogenous Metabolite  
Cancer   Pain  
/
HY-W170255 Sodium mercaptopyruvate
Sodium mercaptopyruvate serves as a substrate for Lactate dehydrogenase and Sulfurtransferase. Sodium mercaptopyruvate forms through enzymatic transamination and oxidative deamination of L-cysteine (HY-Y0337). Sodium mercaptopyruvate abolishes lactate dehydrogenase reaction activity. It increases urinary thiosulfate excretion, fails to sustain rat growth by replacing L-cystine (HY-N0394), and does not induce morbidity or mortality in mice. Sodium mercaptopyruvate is applicable to research related to 3-mercaptopyruvate disulfiduria and 3-mercaptolactate disulfiduria.
Lactate Dehydrogenase   Drug Derivative  
Urologic Disease  
/
HY-B0228S13 Adenosine-13C10
Adenosine-13C10 (Adenine riboside-13C10; D-Adenosine-13C10) is 13C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Isotope-Labeled Compounds   Nucleoside Antimetabolite/Analog   Endogenous Metabolite   Autophagy   Apoptosis  
Cancer   Metabolic or Endocrine Disease  
/
HY-A0181S1 Adenosine monophosphate-15N5 dilithium
Adenosine monophosphate-15N5 dilithium is the 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Isotope-Labeled Compounds   Endogenous Metabolite   Adenosine Receptor   HSV  
Infection   Metabolic or Endocrine Disease  
/
HY-W012642 2-Aminopurine
2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics.
DNA Stain  
/
HY-112502C MethADP triammonium
MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium is a CD73 inhibitor. MethADP can be used for the research of ATP-adenosine pathway.
CD73  
Cancer  
/
HY-A0181R Adenosine monophosphate (Standard)
Adenosine monophosphate (Standard) is the analytical standard of Adenosine monophosphate (HY-A0181). This product is intended for research and analytical applications. Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Reference Standards   Endogenous Metabolite   Adenosine Receptor   HSV  
Cancer   Infection   Metabolic or Endocrine Disease  
/
HY-134426 DL-β-Hydroxybutyryl coenzyme A lithium
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P6292A KS-133 TFA
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC50 values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation.
PACAP Receptor  
Cancer   Neurological, Eye or Ear Disease   Immunomodulation  
/
HY-B0228R Adenosine (Standard)
Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Reference Standards   Nucleoside Antimetabolite/Analog   Autophagy   Apoptosis   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-128748 DL-Glyceraldehyde
DL-Glyceraldehyde is a bioactive substance involved in cellular energy metabolism and a key intermediate in sugar metabolism pathways (such as glycolysis and gluconeogenesis). During glycolysis, DL-Glyceraldehyde is converted by enzymes into other metabolites to provide energy for cells; during gluconeogenesis, DL-Glyceraldehyde participates in the synthesis of glucose as a precursor. In the field of medical research, DL-Glyceraldehyde can be used to study diseases related to sugar metabolism, such as diabetes, tumors, etc[1][2].
Endogenous Metabolite  
Glucose Metabolism  
/
HY-P991097 Pumitamig
Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy.

Species: Human

VEGFR   PD-1/PD-L1  
Ovarian Cancer   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
/
HY-B0228S1 Adenosine-13C5
Adenosine-13C5 is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
Apoptosis   Nucleoside Antimetabolite/Analog   Autophagy   Endogenous Metabolite  
Cancer  
/
HY-P70225 LDHA Protein, Human (His)
LDHA protein catalyzes the stereospecific interconversion of pyruvate and lactate, concomitantly exchanging NADH and NAD(+). LDHA Protein, Human (His) is the recombinant human-derived LDHA protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P75530 ADK/Adenosine Kinase Protein, Human (HEK293)
ADK is an enzyme that catalyzes the transfer of gamma-phosphate from adenosine triphosphate (ATP) to adenosine (Ado) to form adenosine monophosphate (AMP). ADK acts as a potential regulator of extracellular adenosine and intracellular adenine nucleotide concentrations. ADK is a therapeutic target for controlling obesity and non-alcoholic fatty liver disease. ADK/Adenosine Kinase Protein, Human (HEK293) is the recombinant human-derived ADK/Adenosine Kinase protein, expressed by HEK293 , with tag free.

Species: Human; Source: HEK293

Enzymes & Regulators Transferases (EC 2)

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HY-P70259 LDHA Protein, Mouse (HEK293, His)
LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+).LDHA Protein, Mouse (HEK293, His) is the recombinant mouse-derived LDHA protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P73271 LDHA Protein, Rat (His)
The LDHA protein facilitates the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the concomitant exchange of NADH and NAD(+).LDHA Protein, Rat (His) is the recombinant rat-derived LDHA protein, expressed by E.coli , with N-His labeled tag.

Species: Rat; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P74429 Adenosine Deaminase/ADA Protein, Human (sf9, His)
The adenosine deaminase/ADA protein catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine, which is critical for purine metabolism and adenosine homeostasis. It affects cell signaling indirectly by regulating extracellular adenosine. Adenosine Deaminase/ADA Protein, Human (sf9, His) is the recombinant human-derived Adenosine Deaminase/ADA protein, expressed by Sf9 insect cells , with C-His labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Hydrolases (EC 3)

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HY-P77134 LDH Protein, P. falciparum (His)
The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. LDH Protein, P. falciparum (His) is the recombinant LDH protein, expressed by E. coli , with C-His labeled tag.

Species: Others; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P76250 CECR1 Protein, Human (sf9, His)
CECR1, an adenosine deaminase, degrades extracellular adenosine, a pivotal signaling molecule, with activity dependent on elevated adenosine levels. It binds cell surfaces through proteoglycans, hinting at roles in cell proliferation and differentiation beyond its enzyme function. This dual functionality highlights its potential significance in cellular regulatory processes. CECR1 Protein, Human (sf9, His) is the recombinant human-derived CECR1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Hydrolases (EC 3)

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HY-P702202 ADORA1 Protein, Human (Cell-Free, His)
ADORA1 Protein, a receptor for adenosine, inhibits adenylyl cyclase through G proteins, modulating cellular activity. ADORA1 Protein, Human (Cell-Free, His) is the recombinant human-derived ADORA1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of ADORA1 Protein, Human (Cell-Free, His) is 326 a.a., with molecular weight of 39.3 kDa.

Species: Human; Source: E. coli Cell-free

Receptor Proteins G-Protein-Coupled Receptors (GPCRs) Adenosine Receptor

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HY-P703633 METTL14-METTL3 Protein, Human (sf9, His, Strep)
METTL3 and METTL14 are important players in RNA methylation specifically involved in N6-methyladenosine (m6A) modification. METTL3 and METTL14 have shown associations with certain cancers and neurological disorders. METTL14-METTL3 Protein, Human (sf9, His, Strep) is expressed by Sf9 insect cells and carries Strep and His tags.

Species: Human; Source: Sf9 insect cells

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HY-P71522 IIdD Protein, E.coli (His)
GLO1/Glyoxalase I Protein catalyzes the conversion of hemimercaptal to S-lactoylglutathione, detoxifying cytotoxic methylglyoxal produced in glycolysis. Beyond detoxification, GLO1 regulates NF-kappa-B transcriptional activity in TNF-induced pathways, indicating its role in inflammation. Additionally, GLO1 is crucial for normal osteoclastogenesis, emphasizing its broader involvement in cellular processes. IIdD Protein, E.coli (His) is the recombinant E. coli-derived IIdD protein, expressed by E. coli , with N-His labeled tag.

Species: E.coli; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P702855 LDHC Protein, Human (sf9, His)
LDHC Protein, Human (sf9, His) is the recombinant human-derived LDHC, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P73270 LDHA Protein, Mouse (His)
LDHA protein catalyzes the simultaneous and stereospecific interconversion of pyruvate and lactate, accompanied by the reciprocal interconversion of NADH and NAD(+).LDHA Protein, Mouse (His) is the recombinant mouse-derived LDHA protein, expressed by E.coli , with N-His labeled tag.

Species: Mouse; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P75529 ADK/Adenosine Kinase Protein, Human (sf9, His-GST)
ADK is an enzyme that catalyzes the transfer of gamma-phosphate from adenosine triphosphate (ATP) to adenosine (Ado) to form adenosine monophosphate (AMP). ADK acts as a potential regulator of extracellular adenosine and intracellular adenine nucleotide concentrations. ADK is a therapeutic target for controlling obesity and non-alcoholic fatty liver disease. ADK/Adenosine Kinase Protein, Human (sf9, His-GST) is the recombinant human-derived ADK/Adenosine Kinase protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Transferases (EC 2)

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HY-P700899 ADORA2A Protein-VLP, Human (HEK293)
ADORA2A Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

Species: Human; Source: HEK293

Receptor Proteins G-Protein-Coupled Receptors (GPCRs) Adenosine Receptor

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HY-P706213 ADORA2A Protein-VLP, Human (HEK293, His)
ADORA2A Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HHY-P701236.

Species: Human; Source: HEK293

Receptor Proteins G-Protein-Coupled Receptors (GPCRs) Adhesion GPCRs

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HY-P701500 UEVLD Protein, Human (sf9)
UEVLD proteins are considered potential negative regulators of polyubiquitination, possibly controlling the ubiquitin-proteasome system. Its ability to form homodimers suggests that it has self-interacting properties, which may contribute to its role in regulating polyubiquitin chains. UEVLD Protein, Human (sf9) is the recombinant human-derived UEVLD protein, expressed by sf9 insect cells , with tag free.

Species: Human; Source: Sf9 insect cells

Ubiquitin Related Proteins

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HY-P702912 METTL3 Protein, Human (sf9, FLAG)
METTL3 Protein, Human (sf9, FLAG) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Transferases (EC 2)

/
HY-P701499 UEVLD Protein, Human (sf9, His, StrepⅡ)
UEVLD proteins are considered potential negative regulators of polyubiquitination, possibly controlling the ubiquitin-proteasome system. Its ability to form homodimers suggests that it has self-interacting properties, which may contribute to its role in regulating polyubiquitin chains. UEVLD Protein, Human (sf9, His, Strep) is the recombinant human-derived UEVLD protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

Species: Human; Source: Sf9 insect cells

Ubiquitin Related Proteins

/
HY-P705470 METTL3 Protein, Human (His)

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

/
HY-P80738 Lactate Dehydrogenase A Antibody (YA317)
Lactate Dehydrogenase A Antibody (YA317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80422 Lactate Dehydrogenase Antibody (YA316)
Lactate Dehydrogenase Antibody (YA316) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

Host: Rabbit; Reactivity: Human, Mouse, Rat, Zebrafish

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83596 Adenosine A1 Receptor Antibody (YA3341)
Adenosine A1 Receptor Antibody (YA3341) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine A1 Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82944 ADK Antibody (YA2689)
ADK Antibody (YA2689) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADK.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86942 LDHD Antibody (YA6635)
LDHD Antibody (YA6635) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LDHD.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86598 METTL3 Antibody (YA6290)
METTL3 Antibody (YA6290) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to METTL3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810451 Adenosine Deaminase Antibody (YA9756)
Adenosine Deaminase Antibody (YA9756) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to Adenosine Deaminase.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P810843 ADAR2 Antibody
ADAR2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ADAR2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P82862 Adenosine Deaminase Antibody (YA2607)
Adenosine Deaminase Antibody (YA2607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine Deaminase.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82862A Adenosine Deaminase Antibody (YA2607)(PBS only)
Adenosine Deaminase Antibody (YA2607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine Deaminase.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80739 Lactate Dehydrogenase C Antibody (YA315)
Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80739A Lactate Dehydrogenase C Antibody (YA315)(PBS only)
Lactate Dehydrogenase C Antibody (YA315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase C.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80994A Lactate Dehydrogenase A Antibody (YA3482)(PBS only)
Lactate Dehydrogenase A Antibody (YA3482) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82944A ADK Antibody (YA2689)(PBS only)
ADK Antibody (YA2689) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADK.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83596A Adenosine A1 Receptor Antibody (YA3341)(PBS only)
Adenosine A1 Receptor Antibody (YA3341) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine A1 Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86602 Lactate Dehydrogenase Antibody (YA6294)
Lactate Dehydrogenase Antibody (YA6294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86628 Lactate Dehydrogenase Isoenzyme V Antibody (YA6320)
Lactate Dehydrogenase Isoenzyme V Antibody (YA6320) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase Isoenzyme V.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80994 Lactate Dehydrogenase A Antibody (YA3482)
Lactate Dehydrogenase A Antibody (YA3482) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lactate Dehydrogenase A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810486 Lactate Dehydrogenase C Antibody
Lactate Dehydrogenase C Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Lactate Dehydrogenase C.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

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Keywords

tumor metabolites | immunometabolism | tumor immune microenvironment | lactate | adenosine | tryptophan metabolism