Topics

Nanoparticles Optimizing CAR-T

Cancer Immunotherapy Intercellular Communication & Diseases Tumor Microenvironment Cellular Stress

Nanoparticles can optimize CAR-T therapy at three distinct stages: gene transfer during manufacturing, pharmacologic support after infusion, and direct generation of CAR-T cells inside the patient. Viral vectors are effective but contribute cost, manufacturing complexity, and integration-related concerns. Lipid, polymer, and other nanomaterial platforms can carry messenger RNA, transposon components, gene editors, proteins, or small molecules to selected immune cells. Biomaterials can also present activation signals or release cytokines with greater spatial control. This flexibility has made nanoparticles a major research direction for reducing production time and improving function, although most in vivo CAR delivery systems remain preclinical and must not be confused with established commercial cell manufacturing The same material class can therefore function as a manufacturing reagent, a drug-delivery vehicle, or the therapeutic gene-transfer product itself[1][2][3].

Particle size, charge, composition, targeting ligand, and cargo release determine which cells take up a formulation and how long expression lasts. Messenger RNA enables transient CAR production without genomic integration, whereas DNA or editing systems may create durable expression but require nuclear access and more extensive safety testing. Nanoparticles targeted to T-cell surface proteins can enrich delivery, yet receptor choice may activate, deplete, or alter the cells being engineered. After infusion, particles can carry cytokines, metabolic modulators, or checkpoint inhibitors to CAR-T cells or the tumor microenvironment. Localized release may improve the therapeutic index by avoiding the systemic exposure produced by soluble immune agonists Endosomal escape is often a major bottleneck because uptake does not guarantee that nucleic acid cargo reaches the cytosol or nucleus intact[1][2].

Practical applications include nonviral ex vivo transfection, synthetic antigen-presenting particles for expansion, implantable or injectable depots that support transferred cells, and targeted nanoparticles for in vivo programming. Transient mRNA CARs may suit situations in which reversible activity is desirable, while durable systems could shorten the conventional vein-to-vein workflow. Nanocarriers may also remodel stroma or myeloid suppression before CAR-T arrival. Each use has a different product definition and regulatory problem: a particle used during closed manufacturing is not equivalent to a system that distributes gene-editing cargo throughout a patient. Complement activation, hepatic or splenic sequestration, unintended immune-cell transfection, and variable biodistribution require direct measurement For solid tumors, a carrier may be designed to reach both the transferred lymphocyte and the suppressive tissue surrounding its target[1][2][3].

Future development should prioritize reproducible composition, scalable production, and single-cell evidence of delivery specificity. Potency assays must connect cargo uptake to functional CAR expression, serial killing, and persistence. In vivo generation requires safeguards that prevent transfection of stem cells, malignant cells, or non-target tissues and permit activity to stop if toxicity occurs. Comparative studies should test nanoparticles against optimized viral and electroporation methods using the same receptor and starting cells. Cost claims also need full accounting of formulation, quality control, and clinical monitoring. Nanoparticles can make CAR-T therapy faster and more programmable, but success will depend on controlling where the cargo travels, which cells express it, and for how long Regulators and clinicians will need a clear boundary between transient cell programming and permanent genetic modification when defining follow-up requirements[1][2][3].

Articles

All
  • All
  • Scientific Reviews
  • EDM
  • Blog
Most Recent
  • Most Recent
  • Oldest

Products

All
  • All
  • Inhibitors & Agonists
  • Isotope-Labeled Compounds
  • Fluorescent Dye
  • Peptides
  • Recombinant Proteins
  • Antibodies
  • Screening Libraries
  • Kits
  • Inhibitory Antibodies
  • Reference Standards
  • Induced Disease Models Products
  • GMP Small Molecules
  • Biochemical Assay Reagents
  • Natural Products
Cat. No. Product Name Information Application Publication
HY-11109 Resatorvid
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.
Toll-like Receptor (TLR)   TNF Receptor   Interleukin Related   Autophagy  
Prostate Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
536
HY-B2176 ATP
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Source: widespread

Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
178
HY-B0240 Disulfiram
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu2+ increases intracellular ROS levels and induces cuproptosis.
Aldehyde Dehydrogenase (ALDH)   Interleukin Related   Pyroptosis   Apoptosis   Cuproptosis  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Autoimmune Disease   Digestive System Inflammation   SARS-CoV-2 Infection  
161
HY-100573 Necrosulfonamide
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.
Mixed Lineage Kinase   Necroptosis   Pyroptosis   Caspase   NOD-like Receptor (NLR)   Keap1-Nrf2   TNF Receptor   Interleukin Related   NO Synthase   Heme Oxygenase (HO)  
Digestive System Disease   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Depression   Digestive System Inflammation   Cardiovascular Disease   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
147
HY-L027 Antiviral Compound Library
Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs. MCE designs a unique collection of 1,237 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.

Disease Focused Libraries

104
HY-L031 Small Molecule Immuno-Oncology Compound Library
Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines. MCE Small Molecule Immuno-Oncology Compound Library offers 831 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Disease Focused Libraries

88
HY-14519 Methotrexate
Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer.
Antifolate   Dihydrofolate reductase (DHFR)   NO Synthase   COX   Interleukin Related  
Breast Cancer   Arthritis   Systemic Lupus Erythematosus   Psoriasis   Lung Fibrosis  
87
HY-L058 Glycolysis Compound Library
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 1,379 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Signaling Pathway Targeting Libraries

86
HY-L0104V UORSY New Generation Screening Library
UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.
83
HY-L0118V Asinex Covalent Inhibitors Library
A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.
83
HY-L0129V MCE Virtual Screening Compound Library1
A collection of over 2 million screening compounds from manufacturers such as VitasM, Specs, Otava and more, available at competitive prices, suitable for virtual screening and AI-driven screening applications.
83
HY-L0130V MCE Virtual Screening Compound Library2
A collection of over 10 million screening compounds from 18+ manufacturers. The data has been cleaned, suitable for virtual screening and AI screening.
83
HY-L096 Inactive Ingredient Library
An inactive ingredient is any component of a drug product other than the active ingredient. Inactive ingredients are added during the manufacturing process of pharmaceutical products such as tablets, capsules, suppositories, and injections. In new drug development, once an inactive ingredient has appeared in an approved drug product for a particular route of administration, the inactive ingredient is not considered new and may require a less extensive review the next time it is included in a new drug product. MCE offers a unique collection of 178 inactive ingredients, which only contain inactive ingredients of the final dosage forms of the drug. MCE Inactive Ingredient library is a powerful tool for aiding in the development of the drug and saving unnecessary time.

Compound Characteristic Classified Libraries

83
HY-L105S Peptide Compound Library
Peptides, composed of amino acids, serve as crucial building blocks for proteins and have gained significant attention in drug development over the past decade. The advancements in production, modification, and analytical technologies have led to a surge in the potential applications of peptides in medicine. Peptides offer a number of advantages over small molecule drugs, including: greater target specificity and efficacy, more predictable metabolic profiles, easier delivery to where they are needed in the body, and fewer side effects. Peptides are increasingly appearing in all branches of medicine as components of innovative drugs, imaging agents, diagnostic agents, and other complex drugs such as peptide-drug conjugates. To date, more than 80 peptide drugs have been approved to treat a variety of diseases, including microbial infections, obesity, anti-diabetes, and cancer, as well as to develop cell targeting platforms and improve cell penetration properties. MCE designs a unique collection of 867 peptide compounds. HY-L105S is a peptide compound library that can be provided with solution form based on HY-L105, and can be applied to peptides-based drug development.

Structure Classified Libraries

83
HY-L214 Liposome Library
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 227 liposome compounds, which is a good tool for drug delivery-related studies.
83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L251 Ionizable Lipid Compound Library
Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application. To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 93 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Structure Classified Libraries

83
HY-L256 Azide Compound Library
In modern drug discovery and chemical biology research, the azide group (-N3) is an important functional moiety that is widely used in click chemistry, biomolecular labeling, drug delivery systems, and prodrug design due to its unique reactivity and bioorthogonality. The MCE Azide Structural Compound Library contains 100 compounds featuring -N3 functional groups. It is designed for the construction of click chemistry reaction systems and the subsequent development of functional molecules. This library enables the rapid assembly of targeting ligands, linkers, and functional molecular modules, thereby accelerating PROTAC assembly, optimization of antibody-drug conjugate (ADC) linkers, and the development of biological labeling probes. In addition, the high reaction selectivity and excellent biocompatibility of the azide group allow it to maintain stable reactivity even in complex biological environments, improving controllability and efficiency in drug design. It serves as an indispensable molecular tool in modern medicinal chemistry and chemical biology research.

Compound Characteristic Classified Libraries

83
HY-L932V0 Kinase Macrocyclic Compound Virtual Library
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.

AI-enabled Libraries

83
HY-L934 CRBN Ligand Library
CRBN, namely cereblon, is the substrate recognition subunit of the E3 ubiquitin ligase complex in the ubiquitin-proteasome system. A CRBN ligand library refers to a collection of numerous fragments that can specifically bind to the CRBN protein. These ligands are mostly designed based on validated CRBN-binding warheads and modified through AI-driven molecular generation optimization systems. They not only include classic lenalidomide-derived structures but also cover novel non-lenalidomide scaffolds. After drug-likeness filtering, these ligands exhibit structural diversity and favorable druggable properties. They can be further optimized and modified to facilitate the development of novel molecular glue degraders, accelerate the discovery of molecular glues that induce interactions between CRBN and new substrate proteins, and enable the exploration of novel CRBN substrates for identifying previously unknown CRBN-binding proteins. MCE compiles 122 fragments that can specifically bind to the CRBN protein, with molecular weights ranging from 200 to 500. Compounds developed based on the library ligands target multiple disease targets such as cancer and autoimmune diseases, further advancing the development of Molecular Glues and PROTACs therapeutic agents.

Featured Fragment Libraries

83
HY-L936V0 Molecular Glue Virtual Library
Molecular Glue Virtual Library is constructed using generative AI technology, integrating the structural features, activity data of known molecular glues, and interaction information of ternary complexes (target protein-E3-molecular glue). Endowed with structural novelty, drug-likeness, diversity and synthesizability, it is applicable to molecular glue-based AI drug screening and large-scale virtual screening. MCE builds this library based on high-quality molecular building blocks by virtue of robust computing power, coupled with rigorous reaction rules and optimized compound generation strategies. To ensure library quality, molecules with high synthetic difficulty, poor drug-likeness, PAINS and other undesirable molecules are excluded first. Subsequently, scaffold-based compound analysis is performed to screen drug-like diverse molecules for synthesizability evaluation; those with excessively high synthetic difficulty are removed, ultimately forming a large-scale molecular glue virtual library with structural diversity, synthesizability and drug-likeness. Compounds in the library can be synthesized in only 1-2 chemical reaction steps. With MCE’s experienced chemical synthesis team, custom synthesis of different scales from milligram to kilogram can be easily achieved to meet diverse customer needs.

AI-enabled Libraries

83
HY-L948 PD-1/PD-L1 Lead-like Library
PD-1/PD-L1 are key immune checkpoint targets that suppress T-cell-mediated anti-tumor immunity, representing a major focus in cancer immunotherapy. While antibody drugs dominate the clinic, they are limited by administration challenges and immune-related side effects. Small-molecule PD-1/PD-L1 inhibitors, with oral availability, good tissue penetration and low cost, have emerged as a promising next-generation strategy. A PD-1/PD-L1 lead-like library was built via a five-step virtual screening process. After collecting 8,947 inhibitors from BindingDB and PubChem and filtering by activity and duplicates, AI similarity screening was performed using GeminiMol. Key pharmacophores were extracted from the PPI interface of co-crystal structures, and molecular was screened via a pharmacophore model, effectively enhancing target activity. Containing 10,000 structurally diverse and drug-like molecules well-matched to the PD-L1 pocket, the library supports virtual docking, high-throughput screening and hit discovery, enabling efficient and rapid development of small-molecule immunotherapies.

Focused and target libraries

83
HY-107202 Polyinosinic-polycytidylic acid
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Digestive System Disease   Prostate Cancer   Pain   Digestive System Inflammation   Lung Fibrosis   Rheumatoid Arthritis  
73
HY-108841 Raleukin
Raleukin (Kineret) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction.

Species: Human

Interleukin Related  
Metastatic Breast Cancer   SARS-CoV-2 Infection   Rheumatoid Arthritis  
57
HY-B1081A Oxidopamine hydrobromide
Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
Dopamine Receptor   Autophagy   Mitophagy   COX   PGE synthase   Interleukin Related   p38 MAPK   Apoptosis   Caspase  
Breast Cancer   Parkinson's Disease  
50
HY-P9926 Dupilumab
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease   Breast Cancer   Non-Small Cell Lung Cancer   Staphylococcus Aureus Infection  
9
HY-P99974 Nab-Paclitaxel
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11).
Microtubule/Tubulin   Apoptosis   Autophagy  
Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
8
HY-P99731 Milatuzumab
Milatuzumab (hLL1; MEDI-115) is a humanized anti-CD74 monoclonal antibody. CD74, a integral membrane protein, is associated with the promotion of B-cell growth and survival. Milatuzumab causes free radical oxygen generation, and loss of mitochondrial membrane potential. Milatuzumaba also decreases CD20/CD74 aggregates and cell adhesion, to lead to cell death.

Species: Human

CD74  
Cancer  
7
HY-W250978 Ovalbumins
Ovalbumins are the major proteins in egg white. Ovalbumins act as an allergen and inducer, and can be applied to mouse models of allergic diseases. Ovalbumins can induce allergic rhinitis in mice via sensitization and nasal challenge. Ovalbumins can be used to establish asthma models.
Ovalbumin, low endotoxin (HY-W250978A) is recommended for model establishment.
Interleukin Related   IFNAR  
Allergic Asthma   Allergic Rhinitis  
6
HY-102022 α-Galactosylceramide
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor).
Transmembrane Glycoprotein   Interleukin Related   CD1  
Inflammation or Immune System Disease   Lung Cancer   Leukemia/Lymphoma/Myeloma   Hepatitis Virus Infection  
4
HY-Y0850O Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed)
Polyvinyl alcohol (PVA; Poly (Ethenol)) (Mw 31000-50000, 87-89% hydrolyzed) is a polymer with emulsifying and stabilizing properties, with a degree of hydrolysis of 87-89%. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) mainly acts as a stabilizer in the preparation of nanomedicines; it not only maintains the structural integrity of PEGylated PLGA nanoparticles during double emulsion synthesis, but also facilitates the preparation of chitosan/matrine-PLGA nanoparticle aqueous solutions and lipid-polymer nanoparticles. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) can be widely used in research related to fields such as breast cancer.
Environmental Pollutants   Biochemical Assay Reagents  
Breast Cancer  
3
HY-135416 Streptolysin O
Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake.

Source: streptococci

Endogenous Metabolite  
Infection  
3
HY-P99042 Polatuzumab
Polatuzumab is a monoclonal antibody that targets CD79b on the surface of B cells. Polatuzumab can be used to synthesize the ADC Polatuzumab Vedotin (HY-132253), which has anti-tumor activity.

Species: Human

Transmembrane Glycoprotein   ADC Antibodies  
CNS Neoplasm   Non-Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
3
HY-41417 Octanoic acid
Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Octanoic acid is also a tremor-suppressing agent.
Environmental Pollutants   Endogenous Metabolite  
Metabolic or Endocrine Disease  
3
HY-P99126 Anti-Mouse/Human CD44 Antibody (IM7)
Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody that recognizes a conserved epitope outside the HA-binding domain of the CD44 molecule. Anti-Mouse/Human CD44 Antibody (IM7) exerts a potent anti-inflammatory effect by inducing the shedding of cell surface CD44, significantly improving symptoms in mice with rheumatoid arthritis without affecting relevant immune responses. Anti-Mouse/Human CD44 Antibody (IM7) can be used for researches on inflammation conditions and cancer such as arthritis and osteosarcoma.

Species: Human/Mouse

Transmembrane Glycoprotein   CD44  
Cancer   Inflammation or Immune System Disease   Arthritis  
3
HY-P9963 Blinatumomab
Blinatumomab (Anatumomab) is a bispecific monoclonal antibody with two binding sites, one for CD3E on T cells and one for CD19 on B cells. Blinatumomab can be used in research for acute lymphoblastic leukemia.

Species: Human

CD19  
Cancer  
3
HY-K1099 Endotoxin Detection Kit (Recombinant Factor C)

MCE Endotoxin Detection Kit (Recombinant Factor C) is suitable for the detection of endotoxins in therapeutic injectable drugs for human use (such as chemical drugs, antibiotics, and biologics), as well as in medical devices including dialysis fluids and implantable devices. It can be applied throughout raw material screening, process development, manufacturing, and commercialization stages.

Cell Biology Cell Analysis Endotoxin Detection

3
HY-113011 Maltotriose
Maltotriose is a maltooligosaccharide and a specific inducer of the Escherichia coli maltose operon. The oligosaccharide structure of Maltotriose acts as a highly efficient drug delivery carrier, which significantly enhances the targeting ability and water solubility of photosensitizers in photodynamic therapy for pancreatic cancer.
Endogenous Metabolite  
2
HY-P99711 Loncastuximab
Loncastuximab (RB4v1.2) is an anti-CD19 monoclonal antibody. Loncastuximab has antitumor activity and can be used in the research of Non-Hodgkin Lymphoma (NHL) and Diffuse Large B-cell Lymphoma (DLBCL). Loncastuximab is capable of synthesizing the ADC molecule Loncastuximab tesirine (HY-P99349).

Species: Human

CD19   ADC Antibodies  
Cancer  
2
HY-W013508 I2959
I2959 is widely used as a photoinitiator for photochemical cross-linking of hydrogels, and the combination of I2959 and CMA hydrogel has been used as a bio-ink for biological 3D printing applications. In addition, I2959 has a high free radical generation efficiency and is cytotoxic to rapidly dividing cell lines.
Biochemical Assay Reagents  
2
HY-P99931 Epcoritamab
Epcoritamab (GEN3013) is an bispecific IgG1 antibody redirecting T-cells toward CD3×CD20+ tumor cells. Epcoritamab induces potent T-cell-mediated cytotoxicity towards B-cell NHL cell lines.

Species: Human

CD3   CD20  
Chronic Lymphocytic Leukemia   Non-Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
2
HY-Y1878C Copper sulfate anhydrous, 99%
Anhydrous copper sulfate, 99% (Cupric sulfate anhydrous, 99%) is an orally administerable disinfectant. Anhydrous copper sulfate, 99% can be used as a biomaterial or organic compound related to life sciences research, and it can increase the Cu content in rat organs.
Environmental Pollutants   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
2
HY-K1041A Seamless DNA Assembly Ultra Kit

MCE Seamless DNA Assembly Ultra Kit is a next-generation recombinant cloning kit that allows the recombination of single or multiple DNA fragments in a single reaction.

Molecular Biology Vector Construction Seamless Cloning

2
HY-P1304A CART(55-102)(human) TFA
CART(55-102)(human) TFA is a human satiety factor with potent appetite-suppressing activity. CART(55-102)(human) TFA is closely associated with leptin and neuropeptide Y.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
1
HY-D1375A Sulfo-Cy5 amine hydrochloride
Sulfo-Cy5 amine hydrochloride is a Cyanine 5 (Cy5) (HY-D0821) dye derivative with an amine group. Sulfo-Cy5 amine hydrochloride can endow silica nanoparticles with fluorescent properties, be internalized by cancer cells, and exhibit enhanced photostability after being incorporated into silica nanoparticles. Its maximum excitation wavelength is approximately 646 nm, and maximum emission wavelength is approximately 662 nm.
Fluorescent Dye  
1
HY-133852 FD-1080
FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging.
Fluorescent Dye   MOFs  
1
HY-17373S1 Posaconazole-d4
Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
Fungal  
Infection  
1
HY-135416A Recombinant Streptolysin O
Recombinant Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Recombinant Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Recombinant Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake.
Endogenous Metabolite  
Infection  
1
HY-P1304 CART(55-102)(human)
CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
1
HY-15108G Purmorphamine (GMP)
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
Smo  
Cancer   Neurological, Eye or Ear Disease  
1
HY-P99285 Denintuzumab
Denintuzumab (hBU 12) is a recombinant humanized anti-CD19 monoclonal antibody. Denintuzumab binds to CD19 on the surface of B cells. Denintuzumab can be used as the antibody moiety (ADC antibody) of antibody-drug conjugates to synthesize ADC, Denintuzumab Mafodotin (SGN-CD19A). Denintuzumab Mafodotin can be used in the research of acute lymphoblastic leukemia.

Species: Human

ADC Antibodies   CD19  
Leukemia/Lymphoma/Myeloma  
1
HY-N5139 Lecithins, egg
Lecithins, egg (Lecithins, egg yolk; Belovo PL 85) is an orally active natural phospholipid mixture extracted from egg yolks. Lecithins, egg inhibits the activities of acetylcholinesterase (AChE) and angiotensin-converting enzyme (ACE). Lecithins, egg exhibits antibacterial, antioxidant and anti-inflammatory activities, and helps delay cellular senescence. Lecithins, egg enhances nerve conduction, improves memory and cognitive function, and exerts positive effects on delaying neurodegenerative diseases. Lecithins, egg promotes lipid absorption and alleviates diarrhea. Lecithins, egg acts as a high-efficiency drug carrier for the preparation of targeted drug delivery systems such as liposomes.
Cholinesterase (ChE)   Angiotensin-converting Enzyme (ACE)   Bacterial  
Digestive System Disease   Bacterial Infection   Neurodegenerative Disease   Oxidative Stress and Inflammation   Lipid Metabolism  
1
HY-D1375 Sulfo-Cy5 amine
Sulfo-Cy5 amine is a Cyanine 5 (Cy5) (HY-D0821) dye derivative with an amine group. Sulfo-Cy5 amine can endow silica nanoparticles with fluorescent properties, be internalized by cancer cells, and exhibit enhanced photostability after being incorporated into silica nanoparticles. Its maximum excitation wavelength is approximately 646 nm, and maximum emission wavelength is approximately 662 nm.
Fluorescent Dye  
1
HY-P10128 GE11
GE11 is a active peptide and combines with colloidal drug delivery systems as smart carriers for antitumor drugs and can be used for cancer study.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
1
HY-153084A CD19 CAR mRNA (Human)
CD19 CAR mRNA (Human) expresses CAR protein that specifically targets human CD19. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia.
mRNA   CD19  
Cancer  
1
HY-132253 Polatuzumab vedotin
Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. The antibody portion is Polatuzumab (HY-P99042), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL).
Antibody-Drug Conjugates (ADCs)   Transmembrane Glycoprotein  
Leukemia/Lymphoma/Myeloma  
1
HY-D1540 Cyanine5.5 amine
Cyanine5.5 amine (Cy 5.5 amine), a Cy5.5 Analogue, is a near-infrared (NIR) fluorescent dye (Ex=648 nm, Em=710 nm). Cyanine5.5 amine can be used in the preparation of Cy5.5-labeled nanoparticles, which can be tracked and imaged with low fluorescence background using confocal microscopy.
Fluorescent Dye  
1
HY-P99113 Inebilizumab
Inebilizumab is an anti-CD19 monoclonal antibody (mAb) with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used for multiple sclerosis and neuromyelitis optica research.

Species: Human

ADC Antibodies   CD19  
Myasthenia gravis   Multiple Sclerosis  
1
HY-P99394 Talquetamab
Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.

Species: Human

CD3  
Cancer  
1
HY-P99592 Solitomab
Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer.

Species: Human

CD3  
Ovarian Cancer  
1
HY-W094581 Gold(III) chloride trihydrate
Gold (III) chloride trihydrate is a reducing agent. Gold (III) chromium trihydrate can be used for chemical synthesis of gold nanoparticles (NP) and spirochromene derivatives.
Biochemical Assay Reagents  
1
HY-P99033 Mosunetuzumab
Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). The Fc region of Mosunetuzumab incorporates a "knob-into-hole" structural modification and an N297G point mutation to achieve heterodimerization and eliminate Fc glycosylation, thereby effectively silencing antibody effector functions.

Species: Human

CD20   CD3  
Cancer Immunology   Non-Hodgkin Lymphoma  
1
HY-P99024 Glofitamab
Glofitamab (RO7082859) is a T-cell-engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab leads to T-cell activation, proliferation, and tumor cell killing upon binding to CD20 on malignant cells. Glofitamab induces durable complete remissions in relapsed or refractory B-Cell non-Hodgkin lymphoma (B-NHL).

Species: Human

CD20   CD3  
Cancer   Inflammation or Immune System Disease  
1
HY-Y1089 4-Dimethylaminopyridine
4-Dimethylaminopyridine is an acyl transfer catalyst. 4-Dimethylaminopyridine is used for labeling and analysis of glycoproteins on the surface of living cells. 4-Dimethylaminopyridine reduces dyskinesia attacks.
Biochemical Assay Reagents   Transmembrane Glycoprotein  
Neurological, Eye or Ear Disease  
1
HY-K2023 In vivo OptiLNP RNA Transfection Reagent (Local Effect)

MCE In vivo OptiLNP RNA Transfection Reagent (Local Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions locally.

Cell Biology Cell Culture Cell Transfection

1
HY-U00449G AGN 193109 (GMP)
AGN 193109 (GMP) is AGN 193109 (HY-U00449) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AGN 193109 is a specific and highly effective retinoic acid receptor (RAR) antagonist. AGN 193109 (GMP) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.
RAR/RXR  
Cancer  
/
HY-P11423 CSK peptide
CSK peptide is a peptide that improves transport of macromolecules across the intestinal mucosal barrier targeting goblet cells. CSK peptide can be used for oral delivery system research.
Others  
/
HY-166975 Polysarcosine 100
Polysarcosine 100 (pSar 100) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 100 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-N15786 DSPE-RGD Lipid sodium
DSPE-RGD Lipid sodium is a lipid containing DSPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
/
HY-N18790 Coconut hydrogenated oil
Coconut oil hydrogenated is a vegetable oil which is hydrogenated. It can be used in food manufactures.
Others  
/
HY-P11221A CLIKKPF acetate
CLIKKPF acetate is a specific peptide segment. CLIKKPF acetate can bind strongly to phosphatidylserine (PS) on the inner layer of the cell membrane. CLIKKPF acetate can enhance the targeting ability of nanoparticles. CLIKKPF acetate can be used in the research of cardiovascular diseases.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-B2221S1 U-13C Cellulose from chicory
U-13C Cellulose from chicory is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-D3214 NIR-Cu(Ⅱ)
NIR-Cu (Ⅱ) is a near-infrared fluorescent Cu2+ probe. NIR-Cu (Ⅱ) enables fluorescence imaging of Cu2+ in living mice. NIR-Cu (Ⅱ) reduces self-absorption and exhibits minimal photobleaching, thus supporting in vivo imaging applications.
Fluorescent Dye  
/
HY-P11054 CREKA-YpFFK(Nph)
CREKA-YpFFK(Nph) is a gold nanoparticle surface ligand composed of CREKA and YPFFK (Nph), responsible for tumor targeting and alkaline phosphatase-responsive bond cleavage, respectively. CREKA-YpFFK(Nph) can be used for tumor targeting research.
Others  
/
HY-130921 Sulfo-Cyanine7 carboxylic acid potassium
Sulfo-Cyanine7 carboxylic acid potassium is a near-infrared fluorescent dye. Sulfo-Cyanine7 carboxylic acid potassium is applicable to ex vivo histological imaging of the trigeminal nerve in rats as well as studies on the distribution and retention in brain tissues. Sulfo-Cyanine7 carboxylic acid potassium can serve as a model hydrophilic probe for multiplex biomedical fluorescence imaging (Ex=750 nm, Em=773 nm).
Fluorescent Dye  
/
HY-P11101 plCSA-BP
plCSA-BP is a Placental CSA-binding peptide. plCSA-BP binds specifically to trophoblasts and not to other cell types in the placenta or to CSA-expressing cells in other tissues. plCSA-BP can guide nanoparticles for the targeted delivery of payloads (such as Indocyanine green (ICG) (HY-D0711) and Methotrexate (MTX) (HY-14519)) to the placenta, promising for placenta-specific drug delivery.
Biochemical Assay Reagents  
/
HY-158620 Acyclo-5-Br-UTP sodium
Acyclo-5-Br-UTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P10462 SAP15
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation in LPS (HY-D1056)-induced macrophages. SAP15 increases the expression of aggrecan and type II collagen and decreases the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials.
HDAC   NF-κB  
Inflammation or Immune System Disease  
/
HY-W583868S 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62 (1,2-POPE-d62) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.
Isotope-Labeled Compounds  
/
HY-B2221S5 U-13C Cellulose from broccoli
U-13C Cellulose from broccoli is the 13C labeled Cellulose (HY-B2221). Cellulose is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-D1367 Sulfo-Cyanine7 carboxylic acid
Sulfo-Cyanine7 carboxylic acid is a near-infrared fluorescent dye. Sulfo-Cyanine7 carboxylic acid is applicable to ex vivo histological imaging of the trigeminal nerve in rats as well as studies on the distribution and retention in brain tissues. Sulfo-Cyanine7 carboxylic acid can serve as a model hydrophilic probe for multiplex biomedical fluorescence imaging (Ex=750 nm, Em=773 nm).
Fluorescent Dye  
/
HY-P11221 CLIKKPF
CLIKKPF is a specific peptide segment. CLIKKPF can bind with phosphatidylserine (PS) in the inner layer of the cell membrane with high affinity. CLIKKPF can enhance the targeting ability of nanoparticles. CLIKKPF can be used for research on cardiovascular conditions.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-D3242 FD-1080 Maleimide
FD-1080 Maleimide (FD-1080-MAL) is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging.
Fluorescent Dye  
/
HY-12519G Oltipraz (GMP)
Oltipraz (GMP) is Oltipraz (HY-12519) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Oltipraz has an inhibitory effect on HIF-1α activation. Oltipraz is a potent Nrf2 activator.
HIF/HIF Prolyl-Hydroxylase   HIV   Keap1-Nrf2   Parasite  
Cancer  
/
HY-B0401S1 Tolbutamide-13C
Tolbutamide-13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
Isotope-Labeled Compounds   Potassium Channel   Autophagy  
Cancer   Metabolic or Endocrine Disease  
/
HY-W392100C Polycaprolactone diol (MW 10000)
Polycaprolactone diol (MW 10000) is a biocompatible, biodegradable polymer and also a castor oil-based polyurethane additive. Polycaprolactone diol (MW 10000) is used in studies of wound dressings and non-absorbable suture biomaterials.
Biochemical Assay Reagents  
/
HY-N18834 Tall oil
Tall oil is a by-product of the kraft process of wood pulp manufacture when pulping mainly coniferous trees.
Others  
/
HY-W1052215 FA-PEG1000-NH2
FA-PEG1000-NH2 (Folate-PEG1000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
Biochemical Assay Reagents  
/
HY-P992178 ALLO-647
ALLO-647 is a human monoclonal antibody targeting CD52. ALLO-647 transiently and selectively depletes host lymphocytes to promote the proliferation of allogeneic CAR T-cell following infusion. ALLO-647 can be used for the research of B-cell lymphoma and follicular lymphoma.

Species: Human

NF-κB  
Leukemia/Lymphoma/Myeloma  
/
HY-182981A Mannose-PEG2000-Biotin
Mannose-PEG2000-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.
Biochemical Assay Reagents  
/
HY-P99815 Pegacaristim
Pegacaristim is a monoclonal antibody with thrombopoietic activity. Pegacaristim can promote generation of platelets.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-B0797S Etretinate-d3
Etretinate-d3 is the deuterium labeled Etretinate. Etretinate (Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis research.
Apoptosis  
/
HY-P11550 VPGVG
VPGVG is a repeating sequence that constitutes elastin-like peptides. VPGVG is derived from sequences found in the hydrophobic regions of vertebrate elastin. Elastin-like peptides are temperature-responsive biomaterials.
Biochemical Assay Reagents  
/
HY-N11442 Antitumor agent-89
Antitumor agent-89 (Compd OTS-5), a natural compound, weakly suppresses fMLP-induced superoxide generation.

Source: Actiniaria

Others  
Cancer  
/
HY-P10306 Cys-LL37
Cys-LL37 is a biomaterial with antimicrobial properties developed by covalently fixing to the surface of titanium. Cys-LL37 uses a flexible hydrophilic polyethylene glycol spacer and selective n-terminal coupling LL37, a surface peptide layer that kills bacteria on contact is formed. Cys-LL37 can be used in research to develop new antimicrobial biomaterials.
Bacterial  
Infection  
/
HY-41417S2 Octanoic acid-d2
Octanoic acid-d2 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W1052215A FA-PEG2000-NH2
FA-PEG2000-NH2 (Folate-PEG2000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
Biochemical Assay Reagents  
/
HY-158621 AcycloCTP sodium
AcycloCTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P4115 CooP
CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles.
FABP  
Cancer  
/
HY-W040193S2 DSPC-d79
DSPC-d79 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-41417S6 Octanoic acid-d5
Octanoic acid-d5 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P1305A CART(55-102)(rat) TFA
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-N4174 Raddeanoside 20
Raddeanoside 20 is a triterpenoid isolated from the rhizome of Anemone raddeana. Raddeanoside 20 can suppresse superoxide generation.
Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
/
HY-D2619 ICG PEG5000 FA
ICG PEG5000 FA is a fluorescently labeled biomolecule containing Indocyanine green (ICG) (HY-D0711) fluorescent dye, polyethylene glycol (PEG) and Folic acid (FA) (HY-16637). ICG PEG5000 FA is widely used in drug delivery and biomaterial labeling (Ex/Em=785/813 nm).
Fluorescent Dye  
/
HY-B2221S U-13C Cellulose high DP from potato
U-13C Cellulose high DP from potato is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-W775262S Δ9-Tetrahydrocannabinolic acid-d3
Δ9-Tetrahydrocannabinolic acid-d3 is the deuterium labeled Δ9-Tetrahydrocannabinolic acid. Δ9-Tetrahydrocannabinolic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
/
HY-N18241 Hibiscolactone A
Hibiscolactone A is a 2H-naphtho[2,3-b]furan-2-one derivative and a superoxide anion generation inhibitor, which can be isolated from the stems of Pachira aquatica. The IC50 value of Hibiscolactone A against fMLP (HY-P0224)-induced human neutrophil activity (inhibiting superoxide anion generation) is 63.22 μM.
Others  
Inflammation or Immune System Disease  
/
HY-168943 PLGA nanoparticles, 100nm
PLGA nanoparticles, 100nm, are biodegradable tumor-targeting nanocarriers that can serve as drug delivery enhancers and multidrug resistance inhibitors. PLGA nanoparticles, 100nm, passively enriched through the EPR effect and actively targeted via ligand-mediated endocytosis, can encapsulate various antitumor active molecules. PLGA nanoparticles, 100nm can specifically recognize multiple types of tumor cells and improve cellular uptake, cytotoxicity and antiproliferative effects after modification with ligands such as transferrin, folic acid, and RGD. PLGA nanoparticles, 100nm can encapsulate various therapeutic drugs and can be surface modified to achieve targeting, imaging, and prolonged circulation time, making them suitable for cancer-related research.
Biochemical Assay Reagents  
Cancer  
/
HY-W414069 Thiocholesterol
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery.
Endogenous Metabolite   Liposome  
/
HY-B2221S3 U-13C Cellulose high DP from maize
U-13C Cellulose high DP from maize is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-141629S1 N-Palmitoyl-D-sphingomyelin-13C
N-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles.
Isotope-Labeled Compounds   Endogenous Metabolite   Liposome  
/
HY-178736S 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine-d46
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine-d46 (DLPE-d46; 1,2-Dilauroyl-sn-glycero-3-PE-d46) is the deuterium labeled 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE; 1,2-Dilauroyl-sn-glycero-3-PE) is an anionic phospholipid. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine promotes the endocytosis of liposome-DNA complexes into target cells, and subsequently mediates membrane fusion between liposome carriers and endosomes to deliver DNA into the nucleus. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a component of anionic artificial viral envelope liposomes, which deliver plasmid DNA to hepatoma cells without serum inhibition. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine enables the construction of biocompatible non-viral gene delivery vector systems. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is applicable for liposome synthesis.
Isotope-Labeled Compounds   Liposome  
/
HY-P0252B α-MSH free acid
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC50s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-126721 Tetralysine
Tetralysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles.
Biochemical Assay Reagents  
/
HY-166973 Polysarcosine 20
Polysarcosine 20 (pSar 20) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 20 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-182981 Mannose-PEG1000-Biotin
Mannose-PEG1000-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.
Biochemical Assay Reagents  
/
HY-P4975 CART (61-102) (rat)
CART (61-102) (rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
Others  
/
HY-N9676 Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid.
Others  
/
HY-171561G DOTAM-Maleimide triTFA (GMP)
DOTAM-Maleimide triTFA (GMP) is DOTAM-Maleimide triTFA (HY-171561) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAM-Maleimide triTFA is a bifunctional chelator.
Biochemical Assay Reagents  
/
HY-D2314 Cyanine 7-amine chloride hydrochloride
Cyanine 7-amine (chloride hydrochloride) can be used to label cationic nanoparticles (NPs) or to NP conjugates (NPCs). It can track the residence time and clearance of nanoparticles in the body.
Liposome  
/
HY-P10678 d-KYFIL
d-KYFIL is a peptide-based biomaterial that can be used for stereocomplexation and can be used to study the regulation of supramolecular assembly of hydrogel biomaterials.
Biochemical Assay Reagents  
/
HY-P11129 MAGE-A4 (286-294)
MAGE-A4 (286-294) is a polypeptide derived from the 286th to 294th amino acids of the MAGE-A4 protein. MAGE-A4 (286-294) binds HLA-­A*02 with an affinity of 560.08 nM and an IC50 of 8.52 nM. MAGE-A4 (286-294) can be detected in various types of cancers (such as esophageal cancer, lung squamous cell carcinoma, bladder cancer). MAGE-A4 (286-294) can be used to produce CAR-T cells and to develop CAR-T cell therapy.
Others  
Cancer  
/
HY-W013078R 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (Standard)
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) (Standard) is the analytical standard of 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) (HY-W013078). This product is intended for research and analytical applications. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) is a zwitterionic saturated phosphatidylethanolamine bearing two myristoyl (C14:0) chains, and serves as a model membrane component, a neutral lipid component of lipid nanoparticles, and a cocoa butter crystallization nucleating agent. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is used in nucleic acid delivery, construction of artificial cell membrane models, and research on urothelial carcinoma.
Reference Standards   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-16910G WIKI4 (GMP)
WIKI4 (GMP) is WIKI4 (HY-16910) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. WIKI4 is a potent tankyrase inhibitor.
Wnt  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-151998S DMPG-d54
DMPG-d54 is the deuterium labeled DMPG (1,2-Dimyristoyl-sn-glycero-3-phosphatidylglycerol). DMPG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
/
HY-W1052215D FA-PEG5000-NH2
FA-PEG5000-NH2 (Folate-PEG5000-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
Biochemical Assay Reagents  
/
HY-W099490 Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] oxalate
Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] oxalate is a fluorescent dye that can be used for generation of chemiluminescence.
Fluorescent Dye  
/
HY-159176 Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC50s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues.
Cytochrome P450  
/
HY-P992339 cT84.66
cT84.66 is a highly efficient tumor-targeting agent against carcinoembryonic antigen (CEA). cT84.66 engages in bivalent binding with CEA via variable region antigen-binding sites, enabling precise targeting of CEA-producing tumor cells for delivery of therapeutic radiation. cT84.66 exhibits high tumor uptake rate, rapid clearance rate, and excellent tumor-to-blood ratio. With dual functions as an imaging agent and an antibody-directed radiotherapy agent, cT84.66 is widely used in studies of colorectal cancer and metastatic CEA-positive malignancies.

Species: Human

Radionuclide-Drug Conjugates (RDCs)  
Colorectal Cancer  
/
HY-P3692 CART (55-76), rat
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-W1052215B FA-PEG3400-NH2
FA-PEG3400-NH2 (Folate-PEG3400-NH2) is a multifunctional drug delivery system composed of Folic acid (HY-16637), polyethylene glycol (PEG), and NH2. Folic acid (FA) has a high affinity for folic acid receptors and can be used to target cell membrane receptors for drug delivery.
Biochemical Assay Reagents  
/
HY-P11057 FGGH
FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu2+ and S2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu2+ and S2-, respectively) (Ex=488 nm, Em=525 nm), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research.
Fluorescent Dye  
/
HY-158622 AcycloATP sodium
AcycloATP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P1303A CART(62-76)(human,rat) TFA
CART(62-76)(human,rat) TFA is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) TFA can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain.
5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-N15990 4ME 16:0 Diether PE
4ME 16:0 Diether PE is a phospholipid that can be used to prepare lipid nanoparticles for drug delivery.

Source: Methanosarcina barkeri

Biochemical Assay Reagents  
/
HY-158588 3′-Azido-ddCTP sodium
3′-Azido-ddCTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-N1384B (rel)-Ambroxide
(rel)-Ambroxide is the racemic form of Ambroxide (HY-N1384). Ambroxide is a naturally occurring terpenoid. Ambroxide is one of the key constituents of ambergris. Ambroxide is used in the manufacture of high-end perfumes to improve the aroma quality and fragrance lasting time of perfumes.

Source: Physeter catodon L.

Biochemical Assay Reagents  
/
HY-P11186 CALNN
CALNN is a pentapeptide that can be used as a ligand to stabilise and functionalise gold nanoparticles in drug delivery systems.
Others  
Cancer  
/
HY-P4794 Osteoblast-Adhesive Peptide
Osteoblast-Adhesive Peptide (Lys-Arg-Ser-Arg) is an adhesion peptide that can be used as a dental/orthopedic biomaterial to support and enhance osteoblast (anchorage-dependent cell) adhesion. Osteoblasts adhere via both integrin-mediated and proteoglycan-mediated mechanisms. Osteoblast-Adhesive Peptide may be osteoblast- or osteocyte-specific and participate in proteoglycan-mediated osteoblast adhesion.
Others  
/
HY-P10674 QMT-CBT
QMT-CBT is a near-infrared aggregation-induced luminescent photon. After activation of caspase1 (Cas1), QMT-CBT undergoes a CBT-Cys click reaction to form a cyclic dimer QMT-Dimer (the first aggregate) and assembles into nanoparticles (the second aggregate), turning the AIE signal "on" to enhance imaging of Alzheimer's disease (AD).
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-P991213 Nonacog gamma
Nonacog gamma is a coagulation factor IX (FIX) supplement. Nonacog gamma activates coagulation factor X (FX), promotes the generation of thrombin, and then converts fibrinogen into fibrin, forming a stable blood clot to exert hemostatic activity. Nonacog gamma is promising for research of hemophilia B.
Factor XI  
Blood or Cardio-cerebrovascular Disease  
/
HY-158587 3′-Azido-ddGTP sodium
3′-Azido-ddGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-D3152 NRh-Cu
NRh-Cu is a highly sensitive near-infrared fluorescence turn-on indicator and Cu2+-selective probe (λex=680 nm, λem=740 nm). When NRh-Cu interacts with Cu2+, it undergoes a structural transition from a non-fluorescent spirocyclic state to a fluorescent ring-opened state, which drives the enhancement of fluorescence emission. NRh-Cu can be used for Cu2+ imaging in live cells and in vivo.
Fluorescent Dye  
/
HY-P1781A Peptide C105Y TFA
Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles.
Secretin Receptor  
Cancer  
/
HY-168947 Green Fluorescent PLGA nanoparticles, 100nm
Green Fluorescent PLGA nanoparticles, 100nm is a PLGA nanoparticle labeled with a green fluorescent dye and is commonly used in imaging and diagnostic applications.
Fluorescent Dye  
/
HY-166974 Polysarcosine 150
Polysarcosine 150 (pSar 150) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 150 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-D2004 ATTO 488 streptavidin
ATTO 488 streptavidin is a fluorescent reagent that specifically targets and binds to biotin (biotin), formed by the conjugation of ATTO 488 with streptavidin (HY-P3152). ATTO 488 streptavidin enables visualization of the activity of streptavidin immobilized on the surface of polymeric nanoparticles, or acts as a fluorescent probe to detect the selective binding and internalization process of anti-HB-EGF/NA with cells expressing HB-EGF (with no such effect on cells that do not express this receptor). ATTO 488 streptavidin effectively verifies the function of streptavidin conjugated to the surface of nanoparticles and is suitable for research related to atherosclerotic cardiovascular diseases.
Fluorescent Dye  
Atherosclerosis and Inflammation  
/
HY-N19660 (1'S,2'S)-1'-O-Methylvaginol
(1'S,2'S)-1'-O-Methylvaginol, a coumarin found in the fruits of Cnidium monnieri, is an elastase inhibitor. (1'S,2'S)-1'-O-Methylvaginol exhibits 11.99% inhibition of superoxide anion generation and 6.42% inhibition of elastase release by human neutrophils at 10 µg/mL. (1'S,2'S)-1'-O-Methylvaginol can be used for research on inflammatory diseases.
Elastase  
Inflammation or Immune System Disease  
/
HY-P10661 L-KYFIL
L-KYFIL is a pentapeptide that is amorphous on its own. When mixed with D-KYFIL, it transforms from fibrous hydrogels into plate-like networks, resulting in changes in mechanical properties and forming a crystalline state. The mixture can protect L-KYFIL from proteolytic degradation. L-KYFIL can be used to study stereocomplexation behavior of peptide sequences and in the development of biomaterials.
Biochemical Assay Reagents  
/
HY-P10335 SPARC (119-122) (mouse)
SPARC (119-122) (mouse) stimulates endothelial cell proliferation and angiogenesis. SPARC (119-122) (mouse) can be used to enhance neovascularization in modified polypropropylene biomaterials.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-158580 5-CF3-ddUTP sodium
5-CF3-ddUTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-172168A Orange Fluorescent PLGA nanoparticles, 200nm
Orange Fluorescent PLGA nanoparticles, 200nm a nanoparticle made from the polymer PLGA and labeled with an orange fluorescent dye. Orange Fluorescent PLGA nanoparticles, 200nm can be used for drug delivery and for tracing.
Fluorescent Dye  
/
HY-D2217 Cy7 tetrazine
Cy7 tetrazine is a near infrared dye that can be used for in vivo imaging.
Fluorescent Dye  
/
HY-113011R Maltotriose (Standard)
Maltotriose (Standard) is the analytical standard of Maltotriose (HY-13011). This product is intended for research and analytical applications. Maltotriose is a maltooligosaccharide and a specific inducer of the Escherichia coli maltose operon. The oligosaccharide structure of Maltotriose acts as a highly efficient drug delivery carrier, which significantly enhances the targeting ability and water solubility of photosensitizers in photodynamic therapy for pancreatic cancer.
Reference Standards   Endogenous Metabolite  
/
HY-P11808 Glycine ester-serine
Glycine ester-serine is a dipeptide composed of glycine and serine linked together. Glycine ester-serine and its derivatives are widely studied in biomedical fields, such as biomaterial synthesis.
Biochemical Assay Reagents  
/
HY-W040193S1 DSPC-d74
DSPC-d74 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-155902B Mal-PEG1000-OH
Mal-PEG1000-OH was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.
Biochemical Assay Reagents  
/
HY-D2848C Chitosan-Cy5.5 (MW 100000)
Chitosan-Cy5.5 (MW 100000) is a fluorescent dye composed of CY5.5 (HY-D0924) and chitosan. Chitosan-Cy5.5 (MW 100000) can be used for bioimaging, drug delivery and biomaterial research (Ex/Em = 680/710 nm).
Fluorescent Dye  
/
HY-D2848B Chitosan-Cy5.5 (MW 10000)
Chitosan-Cy5.5 (MW 1000) is a fluorescent dye composed of CY5.5 (HY-D0924) and chitosan. Chitosan-Cy5.5 (MW 1000) can be used for bioimaging, drug delivery and biomaterial research (Ex/Em = 680/710 nm).
Fluorescent Dye  
/
HY-172168 Orange Fluorescent PLGA nanoparticles, 100nm
Orange Fluorescent PLGA nanoparticles, 100nm a nanoparticle made from the polymer PLGA and labeled with an orange fluorescent dye. Orange Fluorescent PLGA nanoparticles, 100nm can be used for drug delivery and for tracing.
Fluorescent Dye  
/
HY-D2614 ICG PEG2000 biotin
ICG PEG2000 biotin is a fluorescent dye composed of Indocyanine green (ICG) (HY-D0711), PEG and biotin. Indocyanine green provides it with fluorescent labeling function, PEG enhances its biocompatibility and stability, and biotin can bind to target molecules containing streptavidin to achieve targeted imaging or targeted delivery (Ex/Em=785/813 nm).
Fluorescent Dye  
/
HY-D2618 ICG PEG2000 FA
ICG PEG2000 FA is a fluorescently labeled biomolecule containing Indocyanine green (ICG) (HY-D0711) fluorescent dye, polyethylene glycol (PEG) and Folic acid (FA) (HY-16637). ICG PEG2000 FA is widely used in drug delivery and biomaterial labeling (Ex/Em=785/813 nm).
Fluorescent Dye  
/
HY-P991839 Anti-CD19 Antibody (FMC63)
Anti-CD19 Antibody (FMC63) is an antibody that binds to CD19, with a human Kd value ranging from 0.42 nM to 149 nM. Anti-CD19 Antibody (FMC63) mediates tumor cell killing, cytokine secretion, stable CAR expression, T cell activation and memory differentiation. Anti-CD19 Antibody (FMC63) fails to eliminate lymphoma cells carrying CD19 point mutations or co-expressing FMC63-CAR19, induces higher levels of activation-induced cell death, and reduces cell persistence. Anti-CD19 Antibody (FMC63) can be used in research related to B-cell non-Hodgkin's lymphoma, B-cell acute lymphoblastic leukemia, relapsed or refractory diffuse large B-cell lymphoma, etc.

Species: Human

CD19  
Acute Lymphoblastic Leukemia   Non-Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
/
HY-D2848 Chitosan-Cy5.5 (MW 2000)
Chitosan-Cy5.5 (MW 2000) is a fluorescent dye composed of CY5.5 (HY-D0924) and chitosan. Chitosan-Cy5.5 (MW 2000) can be used for bioimaging, drug delivery and biomaterial research (Ex/Em = 680/710 nm).
Fluorescent Dye  
/
HY-D2848A Chitosan-Cy5.5 (MW 55000)
Chitosan-Cy5.5 (MW 55000) is a fluorescent dye composed of CY5.5 (HY-D0924) and chitosan. Chitosan-Cy5.5 (MW 55000) can be used for bioimaging, drug delivery and biomaterial research (Ex/Em = 680/710 nm).
Fluorescent Dye  
/
HY-116364C AZT triphosphate sodium
AZT triphosphate sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-N2410R N-trans-Feruloyltyramine (Standard)
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research.
Reference Standards   Reactive Oxygen Species (ROS)   Apoptosis  
Cancer   Inflammation or Immune System Disease  
/
HY-17373S3 Posaconazole-d7
Posaconazole-d7 (SCH 56592-d7) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
Isotope-Labeled Compounds  
Cancer   Infection  
/
HY-174353S CYP51-IN-23-d3
CYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum. CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs).
Isotope-Labeled Compounds   Cytochrome P450   Fungal  
Infection  
/
HY-17373S2 Posaconazole-d3
Posaconazole-d3 (SCH 56592-d3) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
Isotope-Labeled Compounds   Fungal   Parasite  
Cancer   Infection  
/
HY-W009400R (2-Dodecen-1-yl)succinic anhydride (Standard)
(2-Dodecen-1-yl)succinic anhydride (Standard) is the analytical standard of (2-Dodecen-1-yl)succinic anhydride (HY-W009400). This product is intended for research and analytical applications. (2-Dodecen-1-yl)succinic anhydride is an organic compound commonly used in certain polymerization reactions. It is used in the manufacture of products such as plastics and resins, and is widely used in certain industrial fields, such as coatings, inks and textile manufacturing. In addition, the compound is also used as a raw material for pharmaceutical intermediates and surfactants.
Others   Reference Standards  
/
HY-13675 ME-143
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo.
Wnt  
Neurological, Eye or Ear Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Hypertension   Lung Fibrosis   Rheumatoid Arthritis  
/
HY-18258S Berberine-d6 chloride
Berberine-d6 (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
Isotope-Labeled Compounds   Topoisomerase   Autophagy   Bacterial   Reactive Oxygen Species (ROS)   Antibiotic   Endogenous Metabolite  
Cancer  
/
HY-10475G AM580 (GMP)
AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist.
RAR/RXR  
Cancer  
/
HY-P991029 Sutacimig
Sutacimig (HMB-001) is a humanized antibody of the (H-γ4_L-κ)_(H-γ4_L-κ) format that targets FⅦa/TREML1. One arm of Sutacimig binds to endogenous FVIIa, thereby prolonging the half-life of FVIIa and increasing its accumulation in the bloodstream, while the other arm binds to TLT-1, which is exclusively expressed on the surface of activated platelets. This localizes endogenous FVIIa to activated platelets, further enhancing the activity of FVIIa. Sutacimig enhances Thrombin generation, fibrin formation, and the formation of stable fibrin-platelet networks at sites of vascular injury. Sutacimig can be used in studies related to Glanzmann thrombasthenia.

Species: Human

Thrombin   Ser/Thr Protease   TREM receptor  
Platelet Disease  
/
HY-17373S Posaconazole-d5
Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
Isotope-Labeled Compounds   Fungal  
Infection  
/
HY-W015308 Methyl nonanoate
Methyl nonanoate is an ester compound obtained by the reaction of methanol and nonanoic acid. It has a fruity aroma and is commonly used as a flavoring agent in a variety of foods such as baked goods, confectionary and beverages. Methyl nonanoate is also used as a fragrance ingredient in the manufacture of perfume, cologne and personal care products. Furthermore, it has applications in industrial settings, for example in the production of solvents, resins and plasticizers.
Biochemical Assay Reagents   Endogenous Metabolite  
/
HY-W127624 Polyoxyethylene monocetyl ether (n=approx. 23)
Polyoxyethylene monocetyl ether (n=approx. 23) is a nonionic surfactant and can be used to manufacture hand sanitizer, laundry detergent, body wash, laundry powder, dish soap, metal cleaning agents and other products.
Biochemical Assay Reagents  
/
HY-W009400 (2-Dodecen-1-yl)succinic anhydride
(2-Dodecen-1-yl)succinic anhydride is an organic compound commonly used in certain polymerization reactions. It is used in the manufacture of products such as plastics and resins, and is widely used in certain industrial fields, such as coatings, inks and textile manufacturing. In addition, the compound is also used as a raw material for pharmaceutical intermediates and surfactants.
Drug Intermediate  
/
HY-P4084A KLA seq acetate
KLA seq acetate is a cell membrane-penetrating α-helical amphipathic model peptide. KLA seq acetate conjugates peptide nucleic acids (PNAs) for delivery to mammalian cells. KLA seq acetate covalently links targeted mRNA and fluorescein to form a delivery system that has low re-export and is less resistant to serum effects.
Others  
/
HY-P3691 CART (1-39), Human
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-42682S1 D(+)-Galactosamine-13C hydrochloride
D(+)-Galactosamine-13C (hydrochloride) is the 13C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and
Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-W013078 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine
1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) is a zwitterionic saturated phosphatidylethanolamine bearing two myristoyl (C14:0) chains, and serves as a model membrane component, a neutral lipid component of lipid nanoparticles, and a cocoa butter crystallization nucleating agent. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is used in nucleic acid delivery, construction of artificial cell membrane models, and research on urothelial carcinoma.

Source: Penicillium expansum

Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P4794A Osteoblast-Adhesive Peptide acetate
Osteoblast-Adhesive Peptide (Lys-Arg-Ser-Arg) acetate is an adhesion peptide that can be used as a dental/orthopedic biomaterial to support and enhance osteoblast (anchorage-dependent cell) adhesion. Osteoblasts adhere via both integrin-mediated and proteoglycan-mediated mechanisms. Osteoblast-Adhesive Peptide acetate may be osteoblast- or osteocyte-specific and participate in proteoglycan-mediated osteoblast adhesion.
Others  
Metabolic or Endocrine Disease  
/
HY-D2615 ICG PEG5000 biotin
ICG PEG5000 biotin is a fluorescent dye composed of Indocyanine green (ICG) (HY-D0711), PEG and biotin. Indocyanine green provides it with fluorescent labeling function, PEG enhances its biocompatibility and stability, and biotin can bind to target molecules containing streptavidin to achieve targeted imaging or targeted delivery (Ex/Em=785/813 nm).
Fluorescent Dye  
/
HY-60351S 5-Aminopyrimidine-d3
5-Aminopyrimidine-d3 is the deuterated form of 5-Aminopyrimidine. 5-Aminopyrimidine is a biochemical reagent that can serve as a biomaterial or an organic compound for research related to life sciences. Its derivatives exhibit antioxidant activity.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-W177335 D-Mannopyranose
D-Mannopyranose (compound 19) is a biochemical reagent that can be used as a biomaterial or organic compound related to life science research.
Biochemical Assay Reagents  
/
HY-D2441 TAT-PEG-Cy3
TAT-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, Cell membrane penetrating peptide (TAT) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. TAT-PEG-Cy3 can be used for cell targeted delivery and biological imaging.
Fluorescent Dye  
Cancer  
/
HY-W087892 Barium diphenylamine-4-sulfonate
Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing.
Biochemical Assay Reagents  
/
HY-P990689 Zifibancimig
Zifibancimig (RO-7250284) is a monoclonal antibody against VEGF-A and Ang-2, with affinities of 4 pM and 2 pM, respectively. Zifibancimig has high stability, maintains target-binding capability under physiological stress and storage conditions, and is designed for sustained long-term ocular delivery via the Port Delivery implant device. Zifibancimig can be used in the research of retinal diseases.

Species: Human

VEGFR  
Retinopathy  
/
HY-W040193S3 DSPC-d83
DSPC-d83 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-116778 Prostaglandin G2
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A2 production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury.
Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W040193S4 DSPC-d4
DSPC-d4 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d4) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-P10679 GPLGLAGGWGERDGS
GPLGLAGGWGERDGS is a peptide with MMP enzyme responsiveness and tumor targeting function, which can be used to monitor enzyme-guided nanoparticle assembly in tumors.
MMP  
/
HY-P11174 CP05
CP05 is a peptide that specifically recognizes an exosome surface marker (CD63). CP05 anchors exosomes to target tissues for in vivo delivery of exosomes.
Exosomes   Transmembrane Glycoprotein  
/
HY-D0151 Tetramethylrhodamine-5-maleimide
Tetramethylrhodamine-5-maleimide is a fluorescent probe with high specificity for cysteine thiol (SH) groups. Tetramethylrhodamine-5-maleimide has high sensitivity, responds rapidly to negatively charged nanoparticles, and shows a concentration-dependent decrease in fluorescence intensity, but it is susceptible to interference from humic acids.
Fluorescent Dye  
/
HY-173592 Keratin methacryloyl
Keratin methacryloyl (KerMA) is a photosensitive biomaterial that can be used to synthesize hydrogels.
Biochemical Assay Reagents  
/
HY-41417S3 Octanoic acid-13C
Octanoic acid-13C is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P990870 Anti-CD19 Antibody (4G7)
Anti-CD19 Antibody (4G7) is an anti-human CD19 IgG1 monoclonal antibody. Anti-CD19 Antibody (4G7) reduces the killing effect of CAR T cells on Raji cells. Anti-CD19 Antibody (4G7) can be used for research on immunology. Anti-CD19 Antibody (4G7) is often used in flow cytometry. The recommend isotype control of Anti-CD19 Antibody (4G7): Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Mouse

CD19   IFNAR   Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P1303 CART(62-76)(human,rat)
CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain.
5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-17447AG Tranylcypromine hydrochloride (GMP)
Tranylcypromine (SKF 385) hydrochloride (GMP) is Tranylcypromine hydrochloride (HY-17447A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine hydrochloride is a potent monoamine oxidase (MAO) inhibitor.
Monoamine Oxidase  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-D0176 Dextrosil KA (65% in water)
Dextrosil KA ((3-Chloro-2-hydroxypropyl) trimethylammonium (chloride)) is a biological dye and indicator that can be used as a biomaterial or organic compound in life science-related research.
Biochemical Assay Reagents  
/
HY-158586 3'-Azido-ddATP sodium solution (100 mM)
3'-Azido-ddATP sodium solution (100 mM) is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P991342 CQY684
CQY684 (PCA062 antibody) is a monoclonal antibody targeting CDH3/P-cadherin, which locks P-cadherin in an X-dimer conformation and enhances the stability of this adhesion structure. CQY684 induces P-cadherin phosphorylation and promotes its dissociation from the cytoplasmic region of P-cadherin. As an endocytosis inducer and lysosome-targeting agent, CQY684 facilitates the internalization of the P-cadherin-CQY684 complex and improves the turnover efficiency of P-cadherin. CQY684 serves as a platform for the delivery of intracellular anticancer compounds, which is achieved through the targeted lysosomal transport of the antibody-P-cadherin complex. CQY684 is applicable to the research of breast cancer, esophageal cancer, and head and neck cancer.

Species: Human

Cadherin  
Breast Cancer   Esophageal Cancer  
/
HY-P6825 Ancelvotide Guraxetan
PNT2001 (LY4181530) is a high-affinity PSMA-targeted radiopharmaceutical ligand precursor. natLu-PNT2001 has an IC50 of 3.1 nM against PSMA. PNT2001 is applicable for PSMA targeting, radiopharmaceutical ligand delivery, and prostate cancer-related research.
PSMA  
Prostate Cancer  
/
HY-B0401S Tolbutamide-d9
Tolbutamide-d9 is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
Potassium Channel   Autophagy  
Cancer   Metabolic or Endocrine Disease  
/
HY-P99825 Relfovetmab
Relfovetmab is a monoclonal antibody and also serves as a single-chain variable fragment component for engineering chimeric antigen receptors (CAR) in modified CAR-T cells. Relfovetmab can be used in studies of cancer and immune disorders.

Species: Feline

Others  
Cancer   Inflammation or Immune System Disease  
/
HY-155902A Mal-PEG2000-OH
Mal-PEG2000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.
Biochemical Assay Reagents  
/
HY-N10450 Kumujian A
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL).
Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease  
/
HY-P5021 Cyclo(Arg-Gly-Asp-(D-Phe)-Glu)
Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) c(RGDfE) is a cyclic RGD peptide targeting integrin αvβ3. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is commonly used for modifying drug loaded nanoparticles. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is often used in cancer research, such as pancreatic cancer.
Integrin  
Pancreatic Cancer  
/
HY-155882 mPEG750-amine
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells.
Biochemical Assay Reagents  
Cancer  
/
HY-41417S1 Octanoic acid-d3
Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N16040 DMG-pSar25
DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations.
Liposome  
/
HY-P4102 Cyclic PSAP peptide
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo.
Others  
Cancer  
/
HY-B2144J Chitosan (≥90% deacetylated,viscosity 650-700 mPa.s)
Chitosan (Deacetylated chitin) (≥90% deacetylated, viscosity 650-700 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated, viscosity 650-700 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
Environmental Pollutants   Fungal   Bacterial   Biochemical Assay Reagents  
Cancer   Infection  
/
HY-P11070 SDSSD
SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.
Others  
/
HY-172174 Red Fluorescent PLGA nanoparticles, 100nm
Red Fluorescent PLGA nanoparticles, 100nm is a nanoparticle made from the polymer PLGA and labeled with a red fluorescent dye. Red Fluorescent PLGA nanoparticles, 100nm can be used for drug delivery and for tracing.
Fluorescent Dye  
/
HY-W105775 Diammonium succinate
Diammonium succinate (Ammonium succinate) is a hydrophobic hydrocarbon compound that can be used to study its interaction with microbial cells, especially the mechanisms of degradation and bioavailability. Diammonium succinate is a biomaterial or organic compound that can be used as a biomaterial or organic compound related to life science research.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-141629S2 N-Palmitoyl-D-sphingomyelin-d9
N-Palmitoyl-D-sphingomyelin-d9 (Sphingomyelin 16:0-d9) is deuterium labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles.
Isotope-Labeled Compounds   Endogenous Metabolite   Liposome  
/
HY-N1384 Ambroxide
Ambroxide is a naturally occurring terpenoid. Ambroxide is one of the key constituents of ambergris. Ambroxide is used in the manufacture of high-end perfumes to improve the aroma quality and fragrance lasting time of perfumes.

Source: Physeter catodon L.

Environmental Pollutants  
/
HY-B0315A Biotin-Vitamin B12
Biotin-Vitamin B12 (Biotin-Cyanocobalamin B12) is the biotinylated Vitamin B12 (HY-B0315). Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Biotin-Vitamin B12 can be used in researches on vitamin B12 transport, cellular uptake, targeted delivery, analytical detection, and other areas.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-B2144I Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
Chitosan (Deacetylated chitin) (≥90% deacetylated,viscosity 10 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated,viscosity 10 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
Environmental Pollutants   Fungal   Bacterial   Biochemical Assay Reagents  
Cancer   Infection  
/
HY-P5533 CRT
CRT, an iron peptide mimic, can bind to apo-transferrin (apo-Tf). CRT can be used to modify nanoparticles, and enhances drug delivery efficiency.
Biochemical Assay Reagents  
Cancer  
/
HY-W008816 Nonanol
Nonan-1-ol is an organic compound commonly used in the manufacture of surfactants and lubricants, among others. It can be used as a detergent, emulsifier and stabilizer, and is widely used in some cosmetics, personal care products and printing inks. In addition, the compound has important applications in certain industrial fields, for example in the production of plastics and rubber.
/
HY-155902 Mal-PEG5000-OH
Mal-PEG5000-OH can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.
Biochemical Assay Reagents  
/
HY-15147G XAV-939 (GMP)
XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor.
PARP  
Cancer   Neurological, Eye or Ear Disease  
/
HY-41417R Octanoic acid (Standard)
Octanoic acid (Standard) is the analytical standard of Octanoic acid. This product is intended for research and analytical applications. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-D1557 Cyanine5.5 tetrazine
Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Fluorescent Dye  
/
HY-76217 2,5-Furandicarboxaldehyde
2,5-Furandicarboxaldehyde (2,5-Diformylfuran), a furan derivative, is a volatile organic compound. 2,5-Furandicarboxaldehyde the aerobic oxidation product of 5-Hydroxymethylfurfural (HY-Y0051), and can be used in organic synthesis and functional polymer manufacture, such as fluorescent material, surfactants, and vitrimer.

Source: Apis mellifera, Apis cerana,and Apis dorsata

Drug Derivative  
/
HY-P10709 CREKA peptide
CREKA peptide is a selective non-covalent binding agent targeting fibrin, type IV collagen, and fibronectin, often used as a targeting ligand to modify delivery carriers. CREKA peptide specifically recognizes fibrin, fibronectin, and type IV collagen that are excessively deposited in the tumor microenvironment or fibrotic tissue, mediating the targeted accumulation of the carrier at the lesion site and promoting drug internalization into target cells (such as cancer cells and activated hepatic stellate cells). CREKA peptide can enhance targeted delivery efficiency, increase drug concentration at the lesion site, and reduce systemic side effects.
Collagen  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-P11428 DBCO-cyclo(RGDfK)
DBCO-cyclo (RGDfK) is a clickable DBCO-modified cyclic RGD peptide, and also a DBCO derivative of cyclo (RGDfK) (HY-P0023). DBCO-cyclo (RGDfK) is synthesized via an amide coupling reaction between DBCO-NHS ester and cyclo (RGDfK). DBCO-cyclo (RGDfK) can react with azide groups through copper-free click chemistry (SPAAC) to immobilize RGD peptides onto biomaterials or hydrogels. The RGD sequence in DBCO-cyclo (RGDfK) is recognizable by cellular integrins and promotes cell adhesion. DBCO-cyclo (RGDfK) can be used in studies related to tissue engineering, 3D cell culture, and surface functionalization of biomaterials.
Drug Derivative   Biochemical Assay Reagents  
/
HY-P990130 Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain.

Species: Mouse/Rat

Transferrin Receptor  
Neurological, Eye or Ear Disease  
/
HY-D0917 NIR-Red Dead Cell-1 Dye
NIR-Red Dead Cell-1 Dye is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). NIR-Red Dead Cell-1 Dye can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. NIR-Red Dead Cell-1 Dye is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. NIR-Red Dead Cell-1 Dye can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. NIR-Red Dead Cell-1 Dye can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies.
DNA Stain  
Cancer  
/
HY-42984 BHQ-2 NHS
BHQ-2 NHS is a fluorescence dark quencher with an absorption spectrum spanning 550-650 nm that overlaps with tetramethylrhodamine (TMR) emission. BHQ-2 NHS quenches TMR fluorescence when conjugated to mesoporous silica nanoparticles. BHQ-2 NHS can be used for the research of cancer.
Biochemical Assay Reagents   Fluorescent Dye  
Cancer  
/
HY-W923198 Fluorescein O-methacrylate
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm).
Fluorescent Dye  
/
HY-P1305 CART(55-102)(rat)
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-W040193S DSPC-d70
DSPC-d70 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70) is the deuterium labeled DSPC (HY-W040193). DSPC is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
Isotope-Labeled Compounds   Liposome  
/
HY-W250152 Polycytidylic acid potassium
Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-Y1369C Manganese sulfate monohydrate, for cell culture
Manganese sulfate monohydrate, for cell culture (Manganous sulfate monohydrate, for cell culture) can be used to prepare micronutrients. Manganese sulfate monohydrate, for cell culture is a biomaterial or organic compound that can be used as a life science research-related material.
Biochemical Assay Reagents  
/
HY-41417S4 Octanoic acid-13C4
Octanoic acid-13C4 is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-41417S Octanoic acid-d15
Octanoic acid-d15 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N2362 DL-Alanine
DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-76194A 3,4-Dihydronaphthalen-1-one
3,4-Dihydronaphthalen-1-one (3,4-Dihydro-1 (2H)-naphthalenone) is a biochemical reagent that can serve as a biomaterial or organic compound for life science-related research.
Biochemical Assay Reagents  
/
HY-126437I Poly-L-lysine hydrobromide (MW 1000-5000)
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer.
Biochemical Assay Reagents   DNA Alkylator/Crosslinker   Amino Acid Derivatives  
Lung Cancer  
/
HY-P99538 Ublituximab
Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects.

Species: Human

CD20  
Cancer  
/
HY-P990049 Becotatug
Becotatug (JMT-101) is a humanized IgG1 monoclonal antibody targeting epidermal growth factor receptor (EGFR), and serves as the antibody component of the antibody-drug conjugate Becotatug vedotin (HY-171265). Becotatug specifically binds to the extracellular domain of EGFR, induces receptor internalization and degradation, blocks the EGFR signaling pathway, and mediates antibody-dependent cellular cytotoxicity. When conjugated to monomethyl auristatin E (MMAE) (HY-15162) via a valine-citrulline cleavable linker, Becotatug enables targeted delivery of cytotoxic drugs to EGFR-positive tumor cells. Becotatug can be used for research related to non-small cell lung cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma..

Species: Human

EGFR   ADC Antibodies  
Non-Small Cell Lung Cancer   Nasopharyngeal Cancer  
/
HY-P99794 Osocimab
Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects.

Species: Human

Factor Xa  
Blood or Cardio-cerebrovascular Disease  
/
HY-145396 PLGA12000-PEG2000-NH2
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma.
Biochemical Assay Reagents  
Cancer  
/
HY-13257G Thiazovivin (GMP)
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor.
ROCK  
Cancer  
/
HY-D0835 Hydroxylapatite (25-45 μm)
Hydroxylapatite (Hydroxyapatite) (25-45 μm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (25-45 μm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (25-45 μm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (25-45 μm) can be used in research on osteoarthritis, gout, and atherosclerosis.

Source: bones

Others  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W145518 Pectin
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa.
Environmental Pollutants   Bacterial   Endogenous Metabolite   Antibiotic  
Cancer   Bacterial Infection  
/
HY-13027G DAPT (GMP)
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor.
γ-secretase  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-N7703 D-Mannuronic acid sodium
D-Mannuronic acid sodium is a uronic acid monosaccharide that is frequently utilized in alginate manufacturing. D-Mannuronic acid can be used for the study of cancer.
Others  
Cancer  
/
HY-141629 N-Palmitoyl-D-sphingomyelin
N-palmitoyl-D-sphingomyelin (sphingomyelin 16:0) is a component of LDL-carrying liposomes. N-palmitoyl-D-sphingomyelin can be used in colorectal cancer research.
Liposome   Endogenous Metabolite  
Cancer  
/
HY-W007599 (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid
(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates.
Drug Derivative  
Cancer  
/
HY-N6613 Polygalacturonic acid
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.
Others  
Inflammation or Immune System Disease  
/
HY-P99976 Anti-Mouse CD19 Antibody (1D3)
Anti-Mouse CD19 Antibody (1D3) is an IgG2a antibody inhibitor targeting mouse CD19. Anti-Mouse CD19 Antibody (1D3) reduces CD19 expression levels on the surface of B cells. Anti-Mouse CD19 Antibody (1D3) inhibits the replication of peritoneal B-1a cells.

Species: Mouse

CD19  
Inflammation or Immune System Disease  
/
HY-N2410 N-trans-Feruloyltyramine
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research.
Reactive Oxygen Species (ROS)   Apoptosis  
Digestive System Disease   Digestive System Inflammation   Parkinson's Disease  
/
HY-D1458 Peroxyfluor 1
Peroxyfluor 1 is a cell-permeable probe for H2O2. Peroxyfluor 1 represents a first-generation, green-fluorescent probe.
Fluorescent Dye  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-158082A TRITC-dextran, MW 20000
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching.
Fluorescent Dye  
/
HY-P99113A Inebilizumab (FUT8-KO)
Inebilizumab (FUT8-KO) is an anti-CD19 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody.Inebilizumab (FUT8-KO) exhibits enhanced ADCC against B cells and can be used for research on multiple sclerosis and neuromyelitis optica.

Species: Human

CD19  
Multiple Sclerosis  
/
HY-P99868 Duvortuxizumab
Duvortuxizumab (MGD 011) is a chimeric humanized IG antibody targeting CD19 and CD3E.

Species: Human

CD19   CD3  
Cancer  
/
HY-P99761 Obexelimab
Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus.

Species: Human

CD19   Apoptosis  
Inflammation or Immune System Disease  
/
HY-W008525 Tris(perfluorophenyl)borane
Tris (perfluorophenyl) borane is a biochemical reagent that can be used as a biomaterial or organic compound for life science-related research.
Biochemical Assay Reagents  
/
HY-P9965 Elotuzumab
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-P990792 Anti-Mouse CD4 Antibody (GK1.5)
Anti-Mouse CD4 Antibody (GK1.5) is an anti-mouse CD4 IgG2b monoclonal antibody. Anti-Mouse CD4 Antibody (GK1.5) can significantly deplete CD4+ T cells. Anti-Mouse CD4 Antibody (GK1.5) can extend the survival rate of xenograft models. Anti-Mouse CD4 Antibody (GK1.5) can be used for research on immunology. The recommend isotype control of Anti-Mouse CD4 Antibody (GK1.5): Rat IgG2b kappa, Isotype Control (HY-P990682).

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease   Melanoma  
/
HY-P99054 Tusamitamab
Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542).

Species: Human

Transmembrane Glycoprotein   ADC Antibodies  
Gastric Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer  
/
HY-P991028 Surovatamig
Surovatamig (AZD0486; TNB-486) is a fully human anti-CD19/CD3 IgG4 bispecific antibody. Surovatamig triggers T cell activation, releases cytotoxic granules, and induces T cell-dependent cellular cytotoxicity and tumor cell lysis. Surovatamig can reduces release of pro-inflammatory cytokines including IL-2, IFNγ, TNF. Surovatamig can be used for the research of cancer, such as B cell non-Hodgkin lymphoma.

Species: Human

CD3   CD19   Interleukin Related   TNF Receptor   IFNAR  
Non-Hodgkin Lymphoma  
/
HY-P991015 Pasritamig
Pasritamig (JNJ-78278343; KLCB-245) is a bispecific T-cell engager (BiTE) that targets the complex of human kallikrein KLK2 and CD3 receptor. Pasritamig redirects the cytotoxicity of T cells to KLK2-expressing tumor cells and induces T cell-mediated lysis of KLK2-expressing prostate cancer cells. Administered via subcutaneous injection, subcutaneous infusion or intravenous infusion, Pasritamig exhibits antitumor activity against metastatic castration-resistant prostate cancer. Pasritamig has a safety profile with an extremely low incidence of cytokine release syndrome and can be safely administered in an outpatient setting. Pasritamig is applicable to the research of metastatic castration-resistant prostate cancer.

Species: Human

CD3  
Castration-Resistant Prostate Cancer  
/
HY-P99971 Gemtuzumab
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Species: Human

ADC Antibodies   Transmembrane Glycoprotein  
Cancer  
/
HY-P990673 Vandortuzumab
Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC).

Species: Human

ADC Antibodies   Transmembrane Glycoprotein   Mitosis  
Castration-Resistant Prostate Cancer  
/
HY-P9954 Catumaxomab
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers.

Species: Human

CD3  
Gastric Cancer   Ovarian Cancer  
/
HY-P990688 Xaluritamig
Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8+ T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma.

Species: Human

CD3  
Castration-Resistant Prostate Cancer  
/
HY-P99392 Teclistamab
Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM).

Species: Human

CD3  
Cancer  
/
HY-P74351 CART Protein, Human (HEK293)
CART Protein, a satiety factor, intricately regulates feeding in connection with leptin and neuropeptide Y. It effectively suppresses regular and starvation-triggered feeding, robustly inhibiting neuropeptide Y-initiated feeding within the hypothalamus. Additionally, CART protein plays a pivotal role in fostering neuronal development and survival in vitro, extending beyond its appetite regulation function. CART Protein, Human (HEK293) is the recombinant human-derived CART protein, expressed by HEK293 , with tag free.

Species: Human; Source: HEK293

/
HY-P74350 CART Protein, Human (HEK293, Fc)
CART Protein, a satiety factor, intricately regulates feeding in connection with leptin and neuropeptide Y. It effectively suppresses regular and starvation-triggered feeding, robustly inhibiting neuropeptide Y-initiated feeding within the hypothalamus. Additionally, CART protein plays a pivotal role in fostering neuronal development and survival in vitro, extending beyond its appetite regulation function. CART Protein, Human (HEK293, Fc) is the recombinant human-derived CART protein, expressed by HEK293 , with C-mFc labeled tag.

Species: Human; Source: HEK293

/
HY-P702967 INCENP Protein, Human (sf9, His)
INCENP Protein, Human (sf9, His) is the recombinant human-derived INCENP, expressed by Sf9 insect cells , with His labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators

/
HY-P703463 AURB-INCENP Protein, Human (Active, sf9, GST, His, StrepⅡ)
AURB is an important serine/threonine protein kinase that plays a critical regulatory role in mitosis within the chromosomal passenger complex (CPC). It is essential for correct chromosome alignment and segregation, stabilizing microtubules and assembling the spindle. AURB/INCENP Protein, Human (Active, Sf9, GST(Active, AURKB), His, Strep (Active, INCENP)) is the recombinant human-derived AURB/INCENP, expressed by Sf9 insect cells, with Strep, His, GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins Other Kinases Aur AURKB/AurB

/
HY-P83063 TRAF4 Antibody (YA2808)
TRAF4 Antibody (YA2808) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRAF4.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P87277 INCENP Antibody (YA6960)
INCENP Antibody (YA6960) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to INCENP.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P87277A INCENP Antibody (YA6960)(PBS only)
INCENP Antibody (YA6960) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to INCENP.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

/
HY-K2022 In vivo OptiLNP RNA Transfection Reagent (Systemic Effect)

MCE In vivo OptiLNP RNA Transfection Reagent (Systemic Effect) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA in experimental animals. The RNA functions systemically.

Cell Biology Cell Culture Cell Transfection

/
HY-K2024 In vivo OptiLNP RNA Transfection Reagent (Liver-targeted)

MCE In vivo OptiLNP RNA Transfection Reagent (Liver-targeted) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA via intravenous injection in experimental animals.

Cell Biology Cell Culture Cell Transfection

/
HY-K2025 In vivo OptiLNP RNA Transfection Reagent (Lung-targeted)

MCE In vivo OptiLNP RNA Transfection Reagent (Lung-targeted) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of mRNA and short-chain RNA via intravenous injection in experimental animals.

Cell Biology Cell Culture Cell Transfection

/
HY-K2030 Lentivirus Packaging Kit

MCE Lentivirus Packaging Kit is based on the second-generation lentiviral packaging system and is also compatible with both second- and third-generation packaging plasmids. Lentiviruses produced using this kit exhibit high infection efficiency and a broad host range, enabling stable and sustained expression of exogenous genes in host cells.

Cell Biology Cell Culture Lentivirus

/
HY-K2033 OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells)

MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology to achieve highly efficient nucleic acid(eg. pDNA、mRNA、sgRNA、siRNA) delivery into Jurkat cells. It is designed for in vitro transfection of Jurkat cells and is well suited for applications in immunotherapy, tumor immunology, and other immune cell-related research.

Cell Biology Cell Culture Cell Transfection

/
HY-K2034 OptiLNP Antibody-ctLNP RNA Transfection Reagent (Human Primary T Cells)

MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology and is specifically optimized for human primary T cells. It enables efficient and targeted RNA delivery, improving transfection efficiency in difficult-to-transfect primary T cells. The kit is ideally suited for applications including CAR-T and TCR-T cell engineering, cancer immunology research, immune cell engineering, and in vitro T cell functional studies.

Cell Biology Cell Culture Cell Transfection

/
HY-K2035 Fluc mRNA (N1-Me-pUTP)

MCE Fluc mRNA (N1-Me-pUTP) is widely used for evaluating lipid nanoparticle (LNP) delivery efficiency, validating mRNA transfection reagents, assessing in vitro and in vivo mRNA expression, IVIS bioluminescence imaging, and screening novel nucleic acid delivery systems. It is commonly used as a positive control or reporter mRNA.

Cell Biology Cell Culture Cell Transfection

/
HY-K3122 Dry Plant-Derived Extracellular Vesicle Isolation and Purification Kit

MCE Dry Plant-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for dried plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

/
HY-K3123 Succulent Plant-Derived Extracellular Vesicle Isolation and Purification Kit

MCE Succulent Plant -Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for succulent plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

/
HY-K3124 Macrofungal-Derived Extracellular Vesicle Isolation and Purification Kit

MCE Macrofungal-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for fungal fruiting body samples. The optimized extraction system facilitates the release of EVs from fungal tissues, while the purification system effectively removes polysaccharides, proteins, phenolic compounds, terpenoids, and other non-vesicular components, enabling efficient isolation and purification of fungal EVs. The isolated macrofungal-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

/
HY-K6141 Human Brain Organoid (Expansion) Kit

MCE Human Brain Organoid (Expansion) Kit contains Human Brain Organoid Expansion Basal Medium and Human Brain Organoid Expansion Culture Supplements. This kit enables the efficient in vitro generation of human forebrain organoids (hFBs). Within this culture system, human brain tissue can spontaneously form organoid structures that faithfully recapitulate key features of in vivo cellular heterogeneity and complex tissue organization.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

/
HY-K6143 Mouse Fetal Brain Organoid (Expansion) Kit

MCE Mouse Fetal Brain Organoid (Expansion) Kit contains Mouse Fetal Brain Organoid Expansion Basal Medium and Mouse Fetal Brain Organoid Expansion Culture Supplement . This kit enables the efficient in vitro generation of mouse fetal brain organoids (mFBs). Within this culture system, mouse fetal brain tissue can spontaneously form organoid structures that faithfully recapitulate key features of in vivo cellular heterogeneity and complex tissue organization.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

/
HY-K6304 Human iPSC/ESC Hepatocyte Induction Differentiation Kit

MCE Human iPSC/ESC Hepatocyte Induction Differentiation Kit enables the efficient generation of hepatocyte-like cells with a high degree of maturation within 21 d. The resulting cells stably express multiple key hepatic functional markers, including albumin (ALB), cytochrome P450 (CYP) family enzymes, and other liver-specific functional molecules, and exhibit typical hepatocellular phenotypes and functions.

Cell Biology 3D Cell Culture PSC Induction Product Series

/
HY-KM0011 0.75 mL Storage Tube (External Screw Cap, Non-sterile)

MCE Storage Tube is manufactured from high-quality PP (polypropylene), offering excellent low-temperature resistance and mechanical strength for long-term sample storage under ultra-low-temperature conditions. Manufactured under stringent quality control, the tubes are free of DNase, RNase, and pyrogens, making them suitable for applications requiring high sample cleanliness.

Biological Laboratory Consumables Sample Storage

/
HY-KM0012 0.75 mL Storage Tube (External Screw Cap, Sterile)

MCE Storage Tube is manufactured from high-quality PP (polypropylene), offering excellent low-temperature resistance and mechanical strength for long-term sample storage under ultra-low-temperature conditions. Manufactured under stringent quality control, the tubes are free of DNase, RNase, and pyrogens, making them suitable for applications requiring high sample cleanliness.

Biological Laboratory Consumables Sample Storage

/
HY-KM0013 1 mL Storage Tube (External Screw Cap, Non-sterile)

MCE Storage Tube is manufactured from high-quality PP (polypropylene), offering excellent low-temperature resistance and mechanical strength for long-term sample storage under ultra-low-temperature conditions. Manufactured under stringent quality control, the tubes are free of DNase, RNase, and pyrogens, making them suitable for applications requiring high sample cleanliness.

Biological Laboratory Consumables Sample Storage

/
HY-KM0014 1 mL Storage Tube (External Screw Cap, Sterile)

MCE Storage Tube is manufactured from high-quality PP (polypropylene), offering excellent low-temperature resistance and mechanical strength for long-term sample storage under ultra-low-temperature conditions. Manufactured under stringent quality control, the tubes are free of DNase, RNase, and pyrogens, making them suitable for applications requiring high sample cleanliness.

Biological Laboratory Consumables Sample Storage

/
HY-KM0015 2 mL Storage Tube (External Screw Cap, Non-sterile)

MCE Storage Tube is manufactured from high-quality PP (polypropylene), offering excellent low-temperature resistance and mechanical strength for long-term sample storage under ultra-low-temperature conditions. Manufactured under stringent quality control, the tubes are free of DNase, RNase, and pyrogens, making them suitable for applications requiring high sample cleanliness.

Biological Laboratory Consumables Sample Storage

/

Keywords

nanoparticles | CAR-T manufacturing | in vivo CAR-T generation | nonviral gene delivery | biomaterials | targeted delivery