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Cryogels System: Strategies For Inflammation Modulation And Wound Healing

Chronic Inflammation Intercellular Communication & Diseases Cellular Stress Oxidative Stress

Cryogels are macroporous hydrogels produced by polymerization or physical gelation under subzero conditions. Ice crystals function as porogens; after thawing or freeze-drying, the material contains large, interconnected pores. This architecture distinguishes cryogels from many conventional hydrogels by combining rapid fluid uptake, elastic recovery, mass transport, and space for cell migration and tissue ingrowth. Natural polymers such as gelatin, collagen, chitosan, silk, agarose, and cellulose and synthetic systems such as poly(ethylene glycol), poly(vinyl alcohol), and methacrylate-based polymers can be tuned for dressings, injectable scaffolds, drug depots, and regenerative constructs. Their clinical value depends on matching pore structure and mechanics to the wound rather than on porosity alone[1][2][3].

A wound-healing cryogel must manage several competing demands. It should absorb exudate without losing integrity, maintain a moist environment, permit gas and nutrient exchange, protect against mechanical stress, and avoid cytotoxic degradation products. Interconnected pores can support immune-cell and fibroblast entry, angiogenesis, and matrix deposition, while chemical functionalization enables adhesion, controlled release, or presentation of regenerative cues. In chronic wounds, additional functions are attractive: antimicrobial activity, bioadhesion, proangiogenic signaling, and local modulation of excessive inflammation. Cellulose illustrates the design flexibility because dissolution, regeneration, solvent choice, freezing rate, temperature, fillers, and drying conditions can all alter morphology and performance[2][3][4].

Antimicrobial cryogel dressings combine the scaffold with antibiotics, antiseptics, metals, peptides, or other antimicrobial agents to reduce infection-associated delay in healing. Cryogels can also carry anti-inflammatory drugs, growth factors, extracellular vesicles, or cells, and injectable formulations may fill irregular defects through minimally invasive delivery. These additions increase functionality but create trade-offs: an antimicrobial concentration effective against bacteria may damage host cells, prolonged anti-inflammatory delivery may impair early defense, and a scaffold that encourages cell infiltration may also retain biofilm. Therapeutic claims therefore require simultaneous assessment of microbial burden, inflammatory state, vascularization, re-epithelialization, matrix organization, and material degradation. Human factors also matter: conformability, pain during dressing changes, transparency for inspection, shelf stability, and compatibility with debridement can determine whether favorable laboratory properties translate into routine wound care. Clear performance standards would facilitate comparison among formulations and indications[1][2][3][4][5].

Translation requires standardized structure–function relationships and clinically relevant testing. Investigators should report pore-size distribution, swelling kinetics, permeability, compressive behavior, sterilization effects, release profiles, degradation, and batch variability. Models should include infected, diabetic, ischemic, or otherwise impaired wounds rather than uncomplicated closure alone, and should compare the cryogel with current dressings and the same payload without the scaffold. Future platforms may combine sensors with responsive drug release or patient-specific 3D fabrication, but added complexity must improve healing, usability, or cost. The most credible cryogel systems will coordinate fluid management, infection control, immune resolution, and tissue support while remaining manufacturable, removable or biodegradable, and safe during repeated clinical use Material-driven inflammation must be evaluated separately from the therapeutic payload, because residual monomer, crosslinker, endotoxin, or degradation products can change macrophage and neutrophil behavior. Pore architecture should remain stable in clinically relevant fluids, and antimicrobial performance should be tested against planktonic organisms and biofilms. Multicenter validation should precede definitive wound-healing trials. Reporting must remain transparent and complete[1][2][3][4][5].

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Cat. No. Product Name Information Application Publication
HY-17589 Chloroquine phosphate
Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
Parasite   Autophagy   SARS-CoV   Toll-like Receptor (TLR)   HIV   Antibiotic  
Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   SARS-CoV-2 Infection   Rheumatoid Arthritis  
1344
HY-17589A Chloroquine
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
Parasite   Autophagy   SARS-CoV   Toll-like Receptor (TLR)   HIV   Antibiotic  
Breast Cancer   Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   SARS-CoV-2 Infection   Rheumatoid Arthritis  
1344
HY-D1056 Lipopolysaccharides, from E. coli O55:B5
Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

Source: surface of Gram-negative bacteria

Toll-like Receptor (TLR)  
Cancer   Pain   Autoimmune Disease   Escherichia Coli Infection  
616
HY-11109 Resatorvid
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.
Toll-like Receptor (TLR)   TNF Receptor   Interleukin Related   Autophagy  
Prostate Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
536
HY-10201 Sorafenib
Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
Raf   VEGFR   FLT3   Autophagy   Apoptosis   STAT   Akt   MMP   Cadherin   p38 MAPK   ERK   MEK   PI3K   PARP   Bcl-2 Family   Ephrin Receptor   PDGFR  
Gastric Cancer   Liver Cancer   Ovarian Cancer   Digestive System Inflammation   Small Cell Lung Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   Metastatic Colorectal Cancer   Metastatic Prostate Cancer   Multiple Myeloma   Metastatic Pancreatic Cancer   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Obesity   Lung Fibrosis  
316
HY-B2176 ATP
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Source: widespread

Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
178
HY-B0240 Disulfiram
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu2+ increases intracellular ROS levels and induces cuproptosis.
Aldehyde Dehydrogenase (ALDH)   Interleukin Related   Pyroptosis   Apoptosis   Cuproptosis  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Autoimmune Disease   Digestive System Inflammation   SARS-CoV-2 Infection  
161
HY-100573 Necrosulfonamide
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.
Mixed Lineage Kinase   Necroptosis   Pyroptosis   Caspase   NOD-like Receptor (NLR)   Keap1-Nrf2   TNF Receptor   Interleukin Related   NO Synthase   Heme Oxygenase (HO)  
Digestive System Disease   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Depression   Digestive System Inflammation   Cardiovascular Disease   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
147
HY-13740 Resiquimod
Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
Toll-like Receptor (TLR)   HCV  
Prostate Cancer   Viral Infection   Depression   Pain   Autoimmune Disease   SARS-CoV-2 Infection   Hepatitis C Virus Infection  
120
HY-10231 PX-478
PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis.
HIF/HIF Prolyl-Hydroxylase   VEGFR   Autophagy  
Blood Disease   Type 1 Diabetes   Atherosclerosis  
115
HY-10255A Sunitinib
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.
VEGFR   PDGFR   IRE1   Mitophagy   Autophagy   Apoptosis  
Neurological, Eye or Ear Disease   Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection   Lung Fibrosis  
113
HY-10981 Lenvatinib
Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities.
VEGFR   FGFR   PDGFR   c-Kit   RET  
Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
104
HY-10331 Regorafenib
Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and antiangiogenic activity.
VEGFR   Autophagy   PDGFR   Raf   RET   c-Kit   FGFR   Tie  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   SARS-CoV-2 Infection   Obesity   Lung Fibrosis  
96
HY-W031727 Hydroxychloroquine
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling.
Parasite   Toll-like Receptor (TLR)   SARS-CoV   Autophagy  
Prostate Cancer   Pancreatic Cancer   Viral Infection   Parasitic Infection   Pain   Rheumatoid Arthritis  
95
HY-L012 Metabolism/Protease Compound Library
Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases. MCE designs a unique collection of 7,360 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

Signaling Pathway Targeting Libraries

89
HY-14519 Methotrexate
Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer.
Antifolate   Dihydrofolate reductase (DHFR)   NO Synthase   COX   Interleukin Related  
Breast Cancer   Arthritis   Systemic Lupus Erythematosus   Psoriasis   Lung Fibrosis  
87
HY-L902 5K Scaffold Library
MCE 5K Scaffold Library consists of 5,000 lead-like compounds. Each compound represents one unique scaffold. All compounds are compatible with Lipinski’s rule (Rule of 5) with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120). Compounds contained within the library have been screened to remove any inappropriate chemical structures, avoiding “false hits”. The sufficient diverse of compound structure makes this library a powerful tool for drug screening.

Distinctive Diversity Libraries

87
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L101 Anti-Liver Cancer Compound Library
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers. Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc. MCE offers a unique collection of 3,003 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Disease Focused Libraries

84
HY-L0093V Chemspace Scaffold derived set
Diversity-based screening continues to be a vital tool for drug discovery. Efficiency and productivity can be improved by using screening libraries that offer maximum diversity whilst retaining drug-like properties. Chemspace Scaffold derived set composes 10,119 compounds, which including 3,373 scaffolds, 3 compounds per each. This library has exceptional coverage of drug-like chemical space.
83
HY-L0113V 1M Drug Fragment-Based Diversity Library
A diversity compound library contains 1,000,000 compounds with drug fragments. Each compound has at least one drug fragment. These selected molecules have 702,902 Bemis-Murcko Scaffolds (BMS) with drug-like chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.
83
HY-L0121V MCE 10K Natural Product-like Compound Library
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways. MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).
83
HY-L0124V Chemspace CNS-Focused Library
The basic requirements for the compounds that are supposed to penetrate the blood-brain barrier are somewhat different from those for the majority of drug discovery projects. Alongside the known problem with delivery of the large and non-polar compounds and their penetrability through the cell membrane, the other issue arises as well: small and polar compounds are not able to pass the Blood-Brain Barrier. Chemspace CNS-focused library comprises quite small, non-polar compounds that are also free from PAINS/toxic fragments and aggregators.
83
HY-L038 Differentiation Inducing Compound Library
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method. MCE Differentiation Inducing Compound Library contains a unique collection of 2,574 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Signaling Pathway Targeting Libraries

83
HY-L088 Angiogenesis-Related Compound Library
Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer). MCE offers a unique collection of 3,660 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

Signaling Pathway Targeting Libraries

83
HY-L105S Peptide Compound Library
Peptides, composed of amino acids, serve as crucial building blocks for proteins and have gained significant attention in drug development over the past decade. The advancements in production, modification, and analytical technologies have led to a surge in the potential applications of peptides in medicine. Peptides offer a number of advantages over small molecule drugs, including: greater target specificity and efficacy, more predictable metabolic profiles, easier delivery to where they are needed in the body, and fewer side effects. Peptides are increasingly appearing in all branches of medicine as components of innovative drugs, imaging agents, diagnostic agents, and other complex drugs such as peptide-drug conjugates. To date, more than 80 peptide drugs have been approved to treat a variety of diseases, including microbial infections, obesity, anti-diabetes, and cancer, as well as to develop cell targeting platforms and improve cell penetration properties. MCE designs a unique collection of 867 peptide compounds. HY-L105S is a peptide compound library that can be provided with solution form based on HY-L105, and can be applied to peptides-based drug development.

Structure Classified Libraries

83
HY-L214 Liposome Library
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 227 liposome compounds, which is a good tool for drug delivery-related studies.
83
HY-L216 Polysaccharides Compound Library
Polysaccharides are long chains of carbohydrate molecules, consisting of multiple smaller monosaccharides. Polysaccharides are found mainly in natural sources such as plants, microorganisms, algae and animals. Polysaccharides have a large number of active functional groups, different chemical compositions and different molecular weight ranges, which determines their diversity in nature and structure. Also in the field of medical research, polysaccharides act as a class of functional compounds and thus play a role. For example, nanocarrier construction, immunomodulation and vaccine development, new strategies for antitumor therapy, tissue regeneration engineering applications and disease diagnosis. With the advancement of glycomics and synthetic biotechnology, human beings are moving from “knowing polysaccharides” to “designing polysaccharides”, which will provide innovative solutions for materials science, precision medicine and sustainable development. MCE offers 70 polysaccharides that can be used in biomedical studies.
83
HY-L245 Natural Product Diversity Scaffold Library
At the forefront of innovative drug discovery, every medicinal chemist faces the challenge of rapidly identifying high-quality hit compounds from vast repositories of chemical resources. The MCE Natural Product Diversity Scaffold Library is the result of a streamlined optimization process built upon our existing natural product collection. Adhering to the rigorous selection principle of "retaining only one representative compound per BMS scaffold", we have concentrated the diversity of thousands of compounds into a high-value, low-redundancy core set containing 2,256 compounds. All compounds are derived from natural sources, inheriting their inherent advantages of structural complexity and drug-likeness. By eliminating redundancy, the library size is significantly reduced without any compromise to chemical diversity. This approach effectively lowers the cost and time required for primary screening while simplifying downstream data analysis and structure-activity relationship (SAR) studies.

Natural Product Screening Libraries

83
HY-L251 Ionizable Lipid Compound Library
Ionizable lipids are a class of specialized, functional lipid molecules with pH-sensitive charge characteristics. They are primarily divided into two major categories: ionizable cationic lipids and ionizable anionic lipids, though the term typically specifies ionizable cationic lipids within the biomedical field. Structurally, these lipids consist of an ionizable hydrophilic headgroup, a biodegradable linker, and hydrophobic tails. Their primary application is serving as the key delivery vehicle in lipid nanoparticles (LNPs) to encapsulate negatively charged nucleic acid macromolecules, such as mRNA vaccines, siRNA therapeutics, and CRISPR gene-editing components. In a physiological, neutral environment, they remain electrically neutral to minimize systemic toxicity and prolong circulation time. Upon entering the acidic microenvironment of cellular endosomes, however, they undergo protonation to become positively charged, thereby inducing membrane fusion and enabling the highly efficient intracellular release of the nucleic acid cargo. Consequently, they serve as the technological cornerstone for bringing nucleic acid therapies into clinical application. To accelerate the translational process of cutting-edge nucleic acid drugs, MCE has meticulously constructed an ionizable lipid compound library containing 93 high-performance molecules, aiming to provide researchers and pharmaceutical professionals with a high-throughput, multi-dimensional lipid screening platform.

Structure Classified Libraries

83
HY-L256 Azide Compound Library
In modern drug discovery and chemical biology research, the azide group (-N3) is an important functional moiety that is widely used in click chemistry, biomolecular labeling, drug delivery systems, and prodrug design due to its unique reactivity and bioorthogonality. The MCE Azide Structural Compound Library contains 100 compounds featuring -N3 functional groups. It is designed for the construction of click chemistry reaction systems and the subsequent development of functional molecules. This library enables the rapid assembly of targeting ligands, linkers, and functional molecular modules, thereby accelerating PROTAC assembly, optimization of antibody-drug conjugate (ADC) linkers, and the development of biological labeling probes. In addition, the high reaction selectivity and excellent biocompatibility of the azide group allow it to maintain stable reactivity even in complex biological environments, improving controllability and efficiency in drug design. It serves as an indispensable molecular tool in modern medicinal chemistry and chemical biology research.

Compound Characteristic Classified Libraries

83
HY-L901 50K Diversity Library
MCE 50K Diversity Library consists of 50,000 lead-like compounds with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120). These compounds were selected by dissimilarity search with an average Tanimoto Coefficient of 0.52. There are 36,857 unique scaffolds and each scaffold 1 to 7 compounds. What’s more, compounds with the same scaffold have as many functional groups as possible, which make abundant chemical spaces. This exceptionally diverse library is highly recommended for random screening against new as well as popular targets based its novel, diverse scaffolds, abundant chemical spaces and the convenience for subsequent modification.

Distinctive Diversity Libraries

83
HY-L905 Natural Product-like Compound Library
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways. MCE 5K Natural Product-like Compound Library consists of 4,813 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

Distinctive Diversity Libraries

83
HY-L927 10K Golden Scaffold Library
Designed to maximize efficiency in hit discovery and optimization, this compound library is built on a foundation of diverse Bemis-Murcko scaffolds, with each scaffold is represented by two specifically derived molecules. This strategy ensures broad chemical space through scaffold diversity while enabling preliminary functional group exploration. This approach provides early structure-activity relationship (SAR) insights for every scaffold, making it a valuable tool for accelerating drug discovery.

Distinctive Diversity Libraries

83
HY-L949 Spirocyclic Privileged Scaffold Lead-like Library
Spirocyclic compounds, with rigid 3D structures, high Fsp³ and strong conformational restriction, are highly privileged scaffolds in small-molecule drug screening. They overcome drawbacks of planar aromatic compounds such as poor solubility, high off-target risks and weak druggability. Their orthogonal bicyclic geometry fits well into protein pockets, improving target affinity, subtype selectivity, metabolic stability and membrane permeability, making them ideal for hit identification against kinases, GPCRs, PPIs and other targets. Spirocyclic scaffolds have been widely applied in oncology, antivirals, hypertension and CNS diseases, leading to many approved drugs and clinical candidates. SAR studies show that spiro-atom chirality, ring size and heteroatom substitution dominate bioactivity and selectivity, with the scaffold mainly serving as a conformational anchor. Azaspirocycles, spirooxindoles and spirosteranes target GPCRs, kinases, MDM2-p53 and PPIs. Approved drugs including irbesartan, spironolactone and rolapitant confirm their druggability, while revumenib and SAR405838 show promise against undruggable targets. The MCE Spirocyclic Druglike Library contains over 1,000 diverse, stereospecific molecules selected by Lipinski’s rules. It covers privileged cores such as azaspirocycles, oxaspirocycles and spirooxindoles. These molecules bear rich chiral centers and distinct 3D orientations, reducing non-specific binding and enhancing screening efficiency. Featuring novel scaffolds, the library offers a highly innovative starting point for drug discovery.

According to Lead-like Structures

83
HY-L950 7-Membered Ring Privileged Scaffold Lead-like Library
Seven-membered rings are privileged medium-sized scaffolds with distinct twist-chair conformations and greater 3D diversity than five- and six-membered rings. Their flexible conformations allow induced-fit protein binding and precise pharmacophore positioning. They also modulate Fsp³, pKa and logP to enhance solubility and permeability. Azepanes, oxepanes and benzodiazepines serve as bioisosteres for hit discovery against GPCRs, ion channels and kinases. Widely found in plant and microbial alkaloids, seven-membered heterocycles show excellent biocompatibility and target affinity. They underpin many approved drugs for CNS, cancer and infectious diseases, including diazepam, imipramine and carbamazepine. Clinical candidates further highlight their unique value. However, high transannular strain and synthetic difficulty limit their availability, leaving them rare in standard screening libraries. MCE 7 Membered Scaffold Library contains 2,792 structurally diverse, lead-like molecules covering azepanes, oxepanes, benzodiazepines and dibenzazepines. With varied substitutions, chiral centers and synthetic accessibility, it fills the shortage of medium-ring scaffolds. Ideal for HTS, virtual screening and SAR studies, these novel, patent-clear compounds offer a distinctive starting point for drug discovery in CNS disorders, oncology, antivirals and challenging targets such as PPIs.

According to Lead-like Structures

83
HY-10374 Semaxinib
Semaxinib (SU5416) is a potent and selective inhibitor of VEGFR (Flk-1/KDR) with an IC50 of 1.23 μM.
VEGFR  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   HIV Infection   Non-Small Cell Lung Cancer   Lung Fibrosis  
81
HY-N1446A Glycerol Monoleate
Glycerol Monoleate is a non-toxic, biodegradable, biocompatible, lipophilic glycerol fatty acid ester. Glycerol Monoleate exhibits hemolytic properties. Glycerol Monoleate is combined with bile salts for use as an emulsifier and absorption enhancer. Glycerol Monoleate can be applied in drug delivery systems and in vitro siRNA delivery.
Endogenous Metabolite  
75
HY-135748 Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   Apoptosis  
Cancer   Digestive System Disease   Pain   Autoimmune Disease   Digestive System Inflammation   Lung Fibrosis  
75
HY-50904 Nintedanib
Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
PDGFR   VEGFR   FGFR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Lung Fibrosis  
75
HY-N0822 Shikonin
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
Exosomes   Chloride Channel   Pyruvate Kinase   NF-κB   TNF Receptor   HIV   AIM2  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
74
HY-107202 Polyinosinic-polycytidylic acid
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Digestive System Disease   Prostate Cancer   Pain   Digestive System Inflammation   Lung Fibrosis   Rheumatoid Arthritis  
73
HY-A0003 Lenalidomide
Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8+ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury.
Molecular Glues   Ligands for E3 Ligase   IKZF Family   Casein Kinase   Apoptosis   Pyroptosis   MDM-2/p53   TNF Receptor  
Inflammation or Immune System Disease   Renal Disease   Chronic Lymphocytic Leukemia   Diffuse Large B-cell Lymphoma   Multiple Myeloma   Myelodysplastic Syndrome   Liver Failure  
63
HY-P9906 Bevacizumab
Bevacizumab (Anti-Human VEGF, Humanized Antibody) is a humanized monoclonal antibody against VEGF-A and an angiogenesis inhibitor. Bevacizumab blocks the interaction between VEGF-A and VEGF receptors. Bevacizumab possesses immunomodulatory properties. Bevacizumab can be used in research on metastatic colorectal cancer, metastatic breast cancer, and non-small cell lung cancer.

Species: Human

VEGFR  
Inflammation or Immune System Disease   Cardiovascular Disease   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   Metastatic Colorectal Cancer  
63
HY-B0180 Imiquimod
Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19.
Toll-like Receptor (TLR)   Autophagy   SARS-CoV   HSV  
Inflammation or Immune System Disease   Metastatic Breast Cancer   SARS-CoV-2 Infection  
62
HY-101952 Prostaglandin E2
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
Organoid   Prostaglandin Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease   Cardiovascular Disease   SARS-CoV-2 Infection   Liver Failure  
62
HY-13016 Cabozantinib
Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis.
VEGFR   c-Met/HGFR   c-Kit   TAM Receptor   FLT3   Apoptosis  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Digestive System Inflammation   Lung Fibrosis  
59
HY-108841 Raleukin
Raleukin (Kineret) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction.

Species: Human

Interleukin Related  
Metastatic Breast Cancer   SARS-CoV-2 Infection   Rheumatoid Arthritis  
57
HY-B1081A Oxidopamine hydrobromide
Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
Dopamine Receptor   Autophagy   Mitophagy   COX   PGE synthase   Interleukin Related   p38 MAPK   Apoptosis   Caspase  
Breast Cancer   Parkinson's Disease  
50
HY-126304 β-Glycerophosphate disodium salt hydrate
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
Phosphatase   Endogenous Metabolite   ERK  
Metabolic or Endocrine Disease   Pancreatic Cancer   Depression   Pain   Lung Fibrosis  
35
HY-N0182 Fisetin
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
Sirtuin   PPAR   TNF Receptor  
Digestive System Disease   Prostate Cancer   Viral Infection   Depression   Digestive System Inflammation   SARS-CoV-2 Infection   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
35
HY-D0886 β-Glycerophosphate disodium salt pentahydrate
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
Phosphatase   Endogenous Metabolite   ERK  
Cancer   Metabolic or Endocrine Disease  
35
HY-P9970 Infliximab
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research.
The component ratio of this product is Active ingredient : Excipients = 9 : 47.

Species: Human

TNF Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Lung Cancer   Breast Cancer  
30
HY-153808 Complete Freund's adjuvant (CFA)
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
25
HY-N7131 Coumarin 6
Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm).
Fluorescent Dye  
24
HY-17389 Genipin
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.
Autophagy  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Glucose Metabolism  
22
HY-P9908 Adalimumab
Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α).

Species: Human

TNF Receptor   Bacterial  
Cancer   Autoimmune Disease  
20
HY-Y0966 Glycine
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.
Ninjurin   Endogenous Metabolite   VEGFR   PROTAC Linkers   iGluR  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Schizophrenia   Pain   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Multiple Myeloma   HSV Infection   SARS-CoV-2 Infection   Alzheimer's Disease   Lung Fibrosis  
18
HY-108847 Etanercept
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
TNF Receptor   Bacterial  
Cancer   Rheumatoid Arthritis  
16
HY-D0251 Fluorescein
Fluorescein (Uranine) is widely used as a fluorescent tracer in medicinal and biological applications and tumor infected tissues tracer. Fluorescein (Uranine) is a representative green fluorophore that has been widely used as a scaffold of practically useful green fluorescent probes.
Fluorescent Dye  
14
HY-P9926 Dupilumab
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease   Breast Cancer   Non-Small Cell Lung Cancer   Staphylococcus Aureus Infection  
9
HY-107632 GYY4137
GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity.
Apoptosis   STAT   NF-κB   NO Synthase   COX   TNF Receptor   Interleukin Related  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
8
HY-P1222B LL-37, human acetate
LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing.
Bacterial  
Inflammation or Immune System Disease   Bacterial Infection  
6
HY-150086 Copper Fluor-4
Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10−13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission).
Fluorescent Dye  
6
HY-P1222A LL-37, human TFA
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing.
Bacterial  
6
HY-P1222 LL-37, human
LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
Bacterial  
Infection  
6
HY-W250978 Ovalbumins
Ovalbumins are the major proteins in egg white. Ovalbumins act as an allergen and inducer, and can be applied to mouse models of allergic diseases. Ovalbumins can induce allergic rhinitis in mice via sensitization and nasal challenge. Ovalbumins can be used to establish asthma models.
Ovalbumin, low endotoxin (HY-W250978A) is recommended for model establishment.
Interleukin Related   IFNAR  
Allergic Asthma   Allergic Rhinitis  
6
HY-Y0850P Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed)
Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 146000-186000 and hydrolytic properties. Polyvinyl alcohol (Mw 146000-186000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A).
Environmental Pollutants   Biochemical Assay Reagents  
Cancer  
3
HY-Y0850L Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed)
Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 85000-124000 and hydrolytic properties. Polyvinyl alcohol (Mw 85000-124000, 99+% hydrolyzed) forms hydrogels that can be used to simulate digestive organs and lesion models for the training of endoscopic ultrasound (EUS) and endoscopic ultrasound elastography (EUS-E). Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients.
Environmental Pollutants   Biochemical Assay Reagents  
Cancer  
3
HY-Y0850M Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed)
Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 85000-124000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient.
Environmental Pollutants   Biochemical Assay Reagents  
3
HY-B1391 D-Panthenol
D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.
Environmental Pollutants   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Glucose Metabolism  
3
HY-Y0850J Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed)
Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 130000-23000 and hydrolytic properties. Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate and polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A).
Environmental Pollutants   Biochemical Assay Reagents  
Cancer  
3
HY-Y0850E Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients.
Environmental Pollutants   Biochemical Assay Reagents  
Cancer   Blood or Cardio-cerebrovascular Disease  
3
HY-P4744 LL-37 amide
LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.
Formyl Peptide Receptor (FPR)   Bacterial  
Cancer   Infection  
2
HY-134636 PAPA NONOate
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.
Endogenous Metabolite  
Glucose Metabolism  
2
HY-P4744A LL-37 amide TFA
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.
Formyl Peptide Receptor (FPR)   Bacterial  
Cancer   Infection  
2
HY-P990131 Anti-Mouse CD47/IAP Antibody (MIAP301)
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse CD47/IAP IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis.

Species: Mouse

CD47  
Melanoma   Klebsiella Pneumoniae Infection   Sepsis  
2
HY-101952S Prostaglandin E2-d4
Prostaglandin E2-d4 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
Prostaglandin Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
2
HY-W013508 I2959
I2959 is widely used as a photoinitiator for photochemical cross-linking of hydrogels, and the combination of I2959 and CMA hydrogel has been used as a bio-ink for biological 3D printing applications. In addition, I2959 has a high free radical generation efficiency and is cytotoxic to rapidly dividing cell lines.
Biochemical Assay Reagents  
2
HY-B1620 Polyvinylpyrrolidone K30
Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
Environmental Pollutants   Biochemical Assay Reagents  
Infection  
2
HY-Y1168 DMTMM
DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials.
Biochemical Assay Reagents  
Breast Cancer   Alzheimer's Disease   Parkinson's Disease  
2
HY-B0055 Azulene
Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry.
HIV  
Viral Infection  
1
HY-N6028 Darutoside
Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. Darutoside reduces edema and pain responses by inhibiting the expression of COX-2 and the migration of inflammatory cells. It regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, alleviating inflammation and promoting wound healing. Through multi-target regulation of metabolic networks, Darutoside significantly alleviates acute gouty arthritis.
COX   NF-κB   Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease  
1
HY-W089353 8-Phenyl-BODIPY 505/515
8-Phenyl-BODIPY 505/515 is a molecular rotor based on the BODIPY scaffold, specifically used as a microviscosity probe. The working principle of 8-Phenyl-BODIPY 505/515 is based on the restriction of molecular motion by viscosity: in a high-viscosity environment, the rotational freedom of its chemical bonds is inhibited, which leads to a significant extension of fluorescence lifetime. This property makes 8-Phenyl-BODIPY 505/515 an effective tool for monitoring changes in the viscosity of intracellular microenvironments via fluorescence lifetime imaging (FLIM) technology.
MOFs   Fluorescent Dye  
1
HY-N6924 Zingibroside R1
Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection.
HIV   PIN1   Fungal   GLUT   Reactive Oxygen Species (ROS)  
Cancer   Metabolic or Endocrine Disease   Viral Infection   Neurodegenerative Disease   Candida Infection   Liver Injury  
1
HY-D2452 Cy3-Cisplatin
Cy3-Cisplatin is a Cyanine 3 fluorescent dye CY3 (HY-D0822) labled Cisplatin (HY-17394). Cy3-Cisplatin can be used for drug delivery, fluorescent labeling, cell imaging and tracking.
Fluorescent Dye  
1
HY-P10128 GE11
GE11 is a active peptide and combines with colloidal drug delivery systems as smart carriers for antitumor drugs and can be used for cancer study.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
1
HY-101952R Prostaglandin E2 (Standard)
Prostaglandin E2 (Standard) is the analytical standard of Prostaglandin E2. This product is intended for research and analytical applications. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
Reference Standards   Prostaglandin Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
1
HY-P990007 Tulisokibart
Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis.

Species: Human

TNF Receptor  
Digestive System Inflammation   Crohn's Disease   Ulcerative Colitis  
1
HY-P72066 ISCU Protein, Human (sf9, His)
ISCU is an important mitochondrial scaffolding protein in the ISC assembly complex and forms the structural basis of [2Fe-2S] cluster assembly. ISCU relies on FXN to centrally receive persulfide during de novo synthesis initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1). ISCU Protein, Human (sf9, His) is the recombinant human-derived ISCU protein, expressed by sf9 insect cells , with N-6*His labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P3386 Selcopintide
Selcopintide (Cpne7-DP) consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin.
Calcium Channel  
Metabolic or Endocrine Disease  
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HY-166975 Polysarcosine 100
Polysarcosine 100 (pSar 100) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 100 can be used in drug delivery research.
Biochemical Assay Reagents  
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HY-N15786 DSPE-RGD Lipid sodium
DSPE-RGD Lipid sodium is a lipid containing DSPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
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HY-P11063 AcfffGk
AcfffGk is a short peptide with the ability to self-assemble into helical nanofibers, forming non-covalently cross-linked hydrogels that serve as scaffolds for 3D cell culture.
Others  
Cancer  
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HY-P2004 FFAGLDD
FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
MMP  
Cancer  
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HY-P4131 MPS-Gαi3
MPS-Gαi3 is a cell penetrating peptide that can be used for drug delivery.
Others  
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HY-172377A Poly(L-lactide) (MW 10000)
Poly(L-lactide) (MW 10000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents.
Biochemical Assay Reagents  
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HY-P11281 GYGGGP(GPP)5GFOGER(GPP)5GPC
GYGGGP(GPP)5GFOGER(GPP)5GPC is a type I collagen mimic that can bind to integrins and modify hydrogels.
Others  
Inflammation or Immune System Disease  
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HY-D3141 DR probe
DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma.
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HY-P10101 APT STAT3, scrambled
APT STAT3, scrambled (APTscr), a control peptide of STAT3-specific aptide (APTSTAT3), does not bind STAT3. APT STAT3, scrambled contains the same trpzip scaffold but with a scrambled sequence in the target-binding site.
STAT  
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HY-P4075 Antennapedia Leader Peptide (CT)
Antennapedia Leader Peptide (CT) is a cell penetrating peptide that can be used for drug delivery.
Others  
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HY-P10687 H3B10-27(13/17αF)
H3B10-27(13/17αF) is an excellent scaffold for further developing reagent candidates and an important tool for understanding the physiological functions of the neuropeptide G protein-coupled receptor RXFP3, and it's very stable in serum.
RXFP Receptor  
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HY-P10675 Peptide K
Peptide K is a self-assembling peptide fiber that can be used to prepare fibrous nanocomposite hydrogels. The fibrous nanocomposite hydrogels have a dynamic network that adapts to cells and enhances cell-matrix and cell-cell interactions, thus significantly promoting the mechanotransduction, metabolic energy, and osteogenesis of encapsulated stem cells.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
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HY-D3027 Human Serum Albumin-Rhodamine
Human Serum Albumin-Rhodamine (HSA-Rhodamine) is a Rhodamine B (HY-Y0016) labeled serum albumin. Human Serum Albumin-Rhodamine plays an important role in fluorescent labeling, drug delivery research, and other fields (Ex/Em = 546/610 nm).
Fluorescent Dye  
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HY-N2546 (+)-Dehydroabietic acid
(+)-Dehydroabietic acid is a diterpenoid. (+)-Dehydroabietic acid can be used for the acrylamide Hydrogel synthesis.
Others  
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HY-N15951 C16 Ceramide-suc-PEG2K-maleimide
C16 Ceramide-suc-PEG2K-maleimide is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.
Liposome  
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HY-109541S3 Colfosceril miristate-d13
Colfosceril miristate-d13 (DMPC-d13) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
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HY-109541S Colfosceril miristate-d58
Colfosceril miristate-d58 (DMPC-d58) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
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HY-P11457 cCBD-LL37
cCBD-LL37 is a chimeric antimicrobial peptide modified with a collagen-binding domain (cCBD) (TKKTLRT). cCBD-LL37 has improved retention on collagen after PBS washing and varying electrostatic conditions. cCBD-LL37 binds to collagen involves both specific and non-specific interactions, initiated by long-range electrostatic forces that transitions to close range or hydrophobic interactions. cCBD-LL37 has potent antimicrobial activity with improved structural stability under different ionic strengths and pH conditions (pH 5.5-8). cCBD-LL37 can be used for biomaterials like collagen-based wound dressings research.
Bacterial  
Infection  
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HY-142985 Oleyl Mesylate
Oleyl Mesylate is a derivative of Oleyl Alcohol. Oleyl Alcohol has been incorporated into various formulations for drug delivery.
Liposome  
Metabolic or Endocrine Disease  
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HY-Y0850U8 PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization)
PVA (Polyvinyl alcohol; Poly(Ethenol)) (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) is a semicrystalline synthetic polymer with excellent biocompatibility and biodegradability, which is non-toxic and non-mutagenic upon oral administration in the human body. PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) can serve as an excipient, inhibitor or coating agent to prepare solid dispersions by absorbing water and inhibiting drug crystal nucleation and growth, and can encapsulate insulin-like growth factor-1. PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) can form physically crosslinked cryogels and degradable films, and is widely used in the construction of vascular grafts, the synthesis of articular cartilage, and studies on dry or minimally invasive ex vivo wounds. PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) also promotes hydrogen peroxide generation and enhances the redox cycle of iron species, thus acting as a sacrificial agent to effectively degrade pollutants.
Biochemical Assay Reagents  
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HY-P11886 GNYTCEVTELTREGETIIELK-N3
GNYTCEVTELTREGETIIELK-N3 (GNYTCEVTELTREGETIIELK-Azide) is a conjugate of an azide (-N3) group and a CD47 functional peptide (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduces the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS) and reduces their accumulation in non-target tissues such as the liver and spleen. The azide group in GNYTCEVTELTREGETIIELK-N3 can undergo click chemistry reactions for applications such as constructing targeted drug delivery systems and nanoparticle modification.
Biochemical Assay Reagents  
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HY-W775262S Δ9-Tetrahydrocannabinolic acid-d3
Δ9-Tetrahydrocannabinolic acid-d3 is the deuterium labeled Δ9-Tetrahydrocannabinolic acid. Δ9-Tetrahydrocannabinolic acid is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
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HY-W414069 Thiocholesterol
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery.
Endogenous Metabolite   Liposome  
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HY-D2962 CAQ
CAQ is a near-infrared fluorescent probe based on a curcumin scaffold (Ex/Em = 565/635). CAQ exhibits high affinity for Aβ1-42 aggregates (Kd = 78.89 nM) and excellent selectivity toward common biomolecules. CAQ’s emission wavelength shows significant solvent dependence. CAQ, by incorporating intramolecular rotation donors and quinoline functional groups, can be used for the specific detection and imaging of Aβ aggregates in Alzheimer's disease.
Fluorescent Dye  
Alzheimer's Disease  
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HY-P2004A FFAGLDD TFA
FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
MMP  
Cancer  
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HY-172377C Poly(L-lactide) (MW 40000)
Poly(L-lactide) (MW 40000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents.
Biochemical Assay Reagents  
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HY-P10556 (KFF)3K
(KFF)3K is a cell penetrating peptide that can promote the absorption of other antibiotics by disrupting the outer membrane of bacteria. (KFF)3K can be introduced into a hydrocarbon scaffold to induce its antibacterial properties, making it an effective antimicrobial peptide. (KFF)3K can be used in the development of new antimicrobial agents.
Bacterial  
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HY-166973 Polysarcosine 20
Polysarcosine 20 (pSar 20) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 20 can be used in drug delivery research.
Biochemical Assay Reagents  
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HY-P11068 RAD-KLT
RAD-KLT is a self-assembling peptide. RAD-KLT significantly enhances endothelial cell survival, proliferation, migration, and morphological tubulogenesis. RAD-KLT can be used for tissue regeneration research.
Others  
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HY-D0886R β-Glycerophosphate disodium salt pentahydrate (Standard)
β-Glycerophosphate disodium salt pentahydrate (Standard) is the analytical standard of β-Glycerophosphate disodium salt pentahydrate (HY-D0886). This product is intended for research and analytical applications. β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
Reference Standards   Phosphatase   Endogenous Metabolite   ERK  
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HY-77817R Pyrrole-2-carboxaldehyde (Standard)
Pyrrole-2-carboxaldehyde (2-Formylpyrrole) Standard is the analytical standard of Pyrrole-2-carboxaldehyde (HY-77817). This product is intended for research and analytical applications. Pyrrole-2-carboxaldehyde is a heterocyclic organic compound that serves as a scaffold for the synthesis of various bioactive compounds.
Reference Standards   Others  
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HY-109541S1 Colfosceril miristate-d4
Colfosceril miristate-d4 (DMPC-d4) is deuterium labeled Colfosceril miristate. Colfosceril miristate is a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
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HY-D3165 DCM-gal-CF
DCM-gal-CF is a fluorescent probe containing a DCM fluorophore scaffold and a D-galactose recognition moiety. DCM-gal-CF itself shows weak fluorescence, and its fluorescence is enhanced after cleavage by β-galactosidase. DCM-gal-CF can be used to detect β-galactosidase activity.
Fluorescent Dye  
Cancer  
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HY-N15803 DOPE-RGD Lipid sodium
DOPE-RGD Lipid sodium is a lipid containing DOPE and RGD peptides that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
Cancer  
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HY-138658 Janelia Fluor® 526, SE
Janelia Fluor 526, SE (JF526,SE) is a fluorogenic yellow fluorescent dye that contains NHS ester group. JF526 is a versatile scaffold for fluorogenic ligands, including labels for genetically encoded self-labeling protein tags and stains for endogenous structures. Janelia Fluor fluorescent dyes can be chemically conjugated to the specific HaloTag substrate (a chloroalkane ligand) to form a fluorescent ligand, rather than binding directly to the HaloTag protein itself. Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute (Ex/Em = 526/550 nm).
Fluorescent Dye  
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HY-151998S DMPG-d54
DMPG-d54 is the deuterium labeled DMPG (1,2-Dimyristoyl-sn-glycero-3-phosphatidylglycerol). DMPG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
Isotope-Labeled Compounds  
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HY-W015820R Phthalide (Standard)
Phthalide (Standard) is an analytical standard of Phthalide. This product is intended for research and analytical applications. Phthalide is a chemical scaffold. Phthalide can be used to synthesize a variety of phthalate derivatives, including anti-inflammatory agents, antimicrobial agents, antioxidants and blood-tumor barrier regulators.
Bacterial   Reference Standards   Biochemical Assay Reagents  
Cancer   Infection   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
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HY-109541S4 Colfosceril miristate-d63
Colfosceril miristate-d63 (DMPC-d63) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
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HY-P11067 PRG peptide
PRG peptide is a self-assembling peptide. PRG peptide significantly enhances endothelial cell survival, proliferation, migration, and morphological tubulogenesis. PRG peptide can be used for tissue regeneration research.
Others  
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HY-143211 Murapalmitine
Murapalmitine is the component of liposomes for drug delivery.
Liposome  
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HY-W006371R (2-Aminoethyl)phosphonic acid (Standard)
(2-Aminoethyl)phosphonic acid (Standard) is the analytical standard of (2-Aminoethyl)phosphonic acid (HY-W006371). This product is intended for research and analytical applications. (2-Aminoethyl)phosphonic acid is an endogenous metabolite and amino acid analog. (2-Aminoethyl)phosphonic acid can be used for the synthesis of biological macromolecules and the preparation of hydrogels.
Reference Standards   Endogenous Metabolite   Drug Intermediate  
Metabolic or Endocrine Disease  
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HY-P4368 Z-APF-CMK
Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP).
Ser/Thr Protease  
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HY-N15990 4ME 16:0 Diether PE
4ME 16:0 Diether PE is a phospholipid that can be used to prepare lipid nanoparticles for drug delivery.

Source: Methanosarcina barkeri

Biochemical Assay Reagents  
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HY-P4080 MPG peptides, Pα
MPG peptides, Pα is an amphipathic carrier peptide that can be used for drug delivery.
Others  
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HY-114844A L-Phenylalanyl-L-glutamic acid TFA
L-Phenylalanyl-L-glutamic acid TFA (H-Phe-Glu-OH TFA) is a dipeptide present in the exudates of alfalfa seedlings, which exhibits high affinity for PEPT2. L-Phenylalanyl-L-glutamic acid TFA can serve as the peptide scaffold of a tyrosyl-tRNA synthetase inhibitor against Staphylococcus aureus.
Amino Acid Derivatives   Drug Intermediate  
Bacterial Infection  
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HY-P11186 CALNN
CALNN is a pentapeptide that can be used as a ligand to stabilise and functionalise gold nanoparticles in drug delivery systems.
Others  
Cancer  
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HY-P6299 MAX8
MAX8 is a synthetic β-hairpin peptide that folds rapidly and self-assembles into a β-sheet-rich fibrous hydrogel network via non-covalent crosslinking. MAX8 hydrogel exhibits excellent shear-thinning and self-healing properties, enabling precise delivery via syringe and maintaining local retention after implantation. MAX8 hydrogel can uniformly encapsulate cells while preserving their viability and morphology, and protect growth factors (e.g., NGF) and chemotherapeutic drugs from degradation. MAX8 is applicable for spinal cord injury repair, medulloblastoma treatment, and three-dimensional high-throughput drug screening.
Biochemical Assay Reagents  
Nervous System Injury   Glioblastoma  
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HY-P5350 FN-A208 fusion peptide
FN-A208 is a biological active peptide. (This peptide is a fusion of A208, derived from murine laminin a1, and the active site of fibronectin (GRGDS), with a glycine spacer. This peptide forms amyloid-like fibrils and promotes formation of actin stress fibers that mediate fibroblast cell attachment, offering it potential as a bioadhesive for tissue regeneration and engineering. FN-A208 interacts with IKVAV receptors and integrins. Its activity is disrupted by the presence of EDTA.)
Others  
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HY-D2734 Heparin-Cy3
Heparin-Cy3 is a fluorescent dye composed of Cy3 (HY-D0822) and Heparin. Heparin-Cy3 can be used for cell tracing and drug delivery.
Fluorescent Dye  
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HY-P11309 QL6 peptide
QL6 peptide is a self-assembling peptide. QL6 peptide can self-assembles into β-sheets bridging the cavity at neutral pH and improves the inhibitory environment by reducing inflammation and tissue scaring. QL6 peptide can be used for synthesis nanofiber scaffolds for spinal cord injuries (SCI) research.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
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HY-166974 Polysarcosine 150
Polysarcosine 150 (pSar 150) is a hydrophilic alternative to PEG that has good targeted drug delivery properties and can remain in the bloodstream longer. Polysarcosine 150 can be used in drug delivery research.
Biochemical Assay Reagents  
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HY-P0316 TP508
TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.
Thrombin   NO Synthase  
Blood or Cardio-cerebrovascular Disease  
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HY-B1392S Esmolol-d7 hydrochloride
Esmolol-d7 hydrochloride is the deuterium labeled Esmolol hydrochloride (HY-B1392). Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 ReceptorEsmolol hydrochloride attenuates post resuscitation myocardial dysfunction. Esmolol hydrochloride improves diabetic wound healing by inhibiting (aldose reductase) and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers.
Isotope-Labeled Compounds   Adrenergic Receptor   Autophagy   Mitophagy  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-D2630 Cy3 HA MA (MW 3000)
Cy3 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
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HY-145782 Witepsol
Witepsol is a selective lipid-based vehicle for use in drug delivery systems.
Liposome  
Metabolic or Endocrine Disease  
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HY-15651S Alvelestat-13C,d3
Alvelestat-13C,d3 (AZD9668-13C,d3) is the deuterated, 13C-labeled Alvelestat (HY-15651). Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis.
Isotope-Labeled Compounds   Elastase   Claudin   Interleukin Related   MMP  
Skin Inflammation   Pulmonary Disease   Aneurysm  
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HY-W704076 Glyceryl monostearate-d5
Glyceryl monostearate-d5 (GMS-d5) is deuterium labeled Glyceryl monostearate. Glyceryl monostearate (GMS) is a single-tailed lipidic monoglyceride that can be used to synthesize nanoliposomes for drug delivery.
Isotope-Labeled Compounds   Liposome  
Cancer  
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HY-116282J Dextran sulfate, low sulfate (MW 5000)
Dextran sulfate, low sulfate (MW 5000), a biopolymer, is a sulfated polysaccharide. Dextran sulfate, low sulfate (MW 5000) has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent.
Bacterial  
Inflammation or Immune System Disease  
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HY-D2651 Cy5 HA MA (MW 50000)
Cy5 HA MA (MW 50000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 50000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
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HY-D2649 Cy5 HA MA (MW 5000)
Cy5 HA MA (MW 5000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 5000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
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HY-D2681 Cy7 HA MA (MW 3000)
Cy7 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
Fluorescent Dye  
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HY-W707384 Candesartan Cilexetil-d11
Candesartan Cilexetil-d11 (TCV-116-d11) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure.
Isotope-Labeled Compounds   Apoptosis   Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-N7131R Coumarin 6 (Standard)
Coumarin 6 (Standard) is the analytical standard of Coumarin 6 (HY-N7131). This product is intended for research and analytical applications. Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm).
Fluorescent Dye   Reference Standards  
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HY-D2632 Cy3 HA MA (MW 10000)
Cy3 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
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HY-D2633 Cy3 HA MA (MW 50000)
Cy3 HA MA (MW 50000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 50000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
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HY-N15825 C24:1 GB3 Ceramide (d18:1/24:1)
C24:1 GB3 Ceramide (d18:1/24:1) is a globoside that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
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HY-N15844 C24:1 GM3 Ceramide (d18:1/24:1)
C24:1 GM3 Ceramide (d18:1/24:1) is a globoside that can be used to prepare lipid nanoparticles for drug delivery.
Biochemical Assay Reagents  
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HY-D2650 Cy5 HA MA (MW 10000)
Cy5 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
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HY-D1386 JF526-Taxol TFA
JF526-Taxol (TFA) is a versatile scaffold for fluorogenic probes including ligands for self-labeling tags, stains for endogenous structures, and spontaneously blinking labels for super-resolution immunofluorescence.
Fluorescent Dye  
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HY-D2634 Cy3 HA MA (MW 100000)
Cy3 HA MA (MW 100000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 100000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
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HY-D2431 Galactose-PEG-Cy3
Galactose-PEG-Cy3 is a Cy3 (HY-D0822) labeled Galactose-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Galactose-PEG improves drug cellular uptake and reduces endosomal degradation, and can be used in drug delivery.
Fluorescent Dye  
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HY-D2648 Cy5 HA MA (MW 3000)
Cy5 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY5 (HY-D0821). Cy5 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 633/670 nm).
Fluorescent Dye  
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HY-D2631 CY3 HA MA (MW 5000)
Cy3 HA MA (MW 5000) is a hyaluronic acid methacrylate labeled with CY3 (HY-D0822). Cy3 HA MA (MW 5000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 550/570 nm).
Fluorescent Dye  
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HY-B0055R Azulene (Standard)
Azulene (Standard) is the analytical standard of Azulene. This product is intended for research and analytical applications. Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry.
Reference Standards   HIV  
Infection  
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HY-D2401F1 Cy5-Polystyrene microsphere (20um)
Cy5-Polystyrene microsphere (20um) is a Cy5 (HY-D0821)-labeled microsphere that can be used for bioimaging and drug delivery.
Fluorescent Dye  
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HY-138622S1 24:0 Lyso PC-d4
24:0 Lyso PC-d44 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.
Isotope-Labeled Compounds  
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HY-DY1104 Copper Fluor-4 (solution)
Copper Fluor-4 (solution) (CF4 (solution)) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 solution has high copper selectivity with a Kd value of 2.9×10?13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 solution is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission).
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
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HY-P10699 MAX1
MAX1 is a synthetic β-hairpin peptide that folds rapidly and self-assembles into a β-sheet-rich fibrous hydrogel network via non-covalent crosslinking. MAX1 hydrogel exhibits excellent shear-thinning and self-healing properties, enabling precise delivery via syringe and maintaining local retention after implantation. MAX1 hydrogel can uniformly encapsulate cells while preserving their viability and morphology, and protect growth factors (e.g., NGF) and chemotherapeutic drugs from degradation. MAX1 is applicable for spinal cord injury repair, medulloblastoma treatment, and three-dimensional high-throughput drug screening.
Biochemical Assay Reagents  
Nervous System Injury   Glioblastoma  
/
HY-W1120356 Bis-PEG12-NHS Ester
Bis-PEG12-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.
Biochemical Assay Reagents  
/
HY-P4117 Penetratin-Arg
Penetratin-Arg is an antimicrobial and is used for drug delivery vehicle.
Bacterial  
Inflammation or Immune System Disease  
/
HY-128737 Methyl β-D-Galactopyranoside
Methyl β-D-Galactopyranoside is a monosaccharide methyl glycoside that serves as the parent scaffold for the preparation of acylated MGP derivatives. Methyl β-D-Galactopyranoside is used in studies related to carbohydrate chemistry and glycoside derivatives.
Bacterial  
Metabolic or Endocrine Disease  
/
HY-109541S2 Colfosceril miristate-d9
Colfosceril miristate-d9 (DMPC-d9) is deuterium labeled Colfosceril miristate. Colfosceril miristate a synthetic phospholipid used in liposomes. Colfosceril miristate is used to study lipid monolayers, bilayers and drug delivery.
Isotope-Labeled Compounds  
Cancer  
/
HY-78985S Benzene-1,3,5-tricarboxylic acid-d3
Benzene-1,3,5-tricarboxylic acid-d3 (Trimesic acid-d3) is the deuterium labeled Benzene-1,3,5-tricarboxylic acid (HY-78985). Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006).
Isotope-Labeled Compounds   Biochemical Assay Reagents   MOFs  
/
HY-P5304A RTQLLWTPAAPTAMA TFA
RTQLLWTPAAPTAMA TFA is a peptide antigen，used for drug delivery in immune response.
Others  
Inflammation or Immune System Disease  
/
HY-D2401F Cy5-Polystyrene microsphere (100nm)
Cy5-Polystyrene microsphere (100 nm) is a Cy5 (HY-D0821)-labeled microsphere that can be used for bioimaging and drug delivery.
Fluorescent Dye  
/
HY-138622S 24:0 Lyso PC-13C6
24:0 Lyso PC-13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery.
Isotope-Labeled Compounds  
/
HY-125553 Hexapeptide-10
Hexapeptide-10 (Serilesine) is a synthetic hexapeptide. Hexapeptide-10 promotes wound healing and tissue remodeling. Hexapeptide-10 is applicable in cosmetic research.
Amino Acid Derivatives  
/
HY-N2540 (±)-Pinocembrin
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.
Free Fatty Acid Receptor  
/
HY-Y0850U9 PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization)
PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is a polyvinyl alcohol with a molecular weight of 67000 and hydrolytic properties. Degree of hydrolysis refers to the conversion rate of acetate groups in the original polyvinyl acetate to hydroxyl groups; PVA (Mw 67000, 87-89% hydrolyzed, ~1400 polymerization) is obtained by hydrolyzing and removing acetate groups after the polymerization of vinyl acetate. Polyvinyl alcohol with different degrees of hydrolysis can be used to form self-crosslinked cryogels and is applied as a biological adjuvant.
Biochemical Assay Reagents  
/
HY-N1507 Tracheloside
Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing.
Estrogen Receptor/ERR  
Breast Cancer   Ovarian Cancer  
/
HY-D2433 Glucose-PEG2000-Cy3
Glucose-PEG2000-Cy3 is a Cy3 (HY-D0822) labeled Glucose-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Glucose-PEG improves drug cellular uptake and reduces endosomal degradation, and can be used in drug delivery.
Fluorescent Dye  
/
HY-W777979 Frutinone A
Frutinone A is a CYP1A2 inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant.
Cytochrome P450   Bacterial  
/
HY-N8693 Withanoside IV
Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19).
COX   Amyloid-β   Sirtuin   Reactive Oxygen Species (ROS)   Apoptosis   SARS-CoV  
SARS-CoV-2 Infection   Alzheimer's Disease  
/
HY-N6577 Astragaloside VI
Astragaloside VI could activate EGFR/ERK signalling pathway to improve wound healing.
EGFR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P0316A TP508 TFA
TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues.
Thrombin   NO Synthase  
Blood or Cardio-cerebrovascular Disease  
/
HY-D2841 FITC-Heparin
FITC-Heparin is a fluorescent dye composed of FITC (HY-66019) and Heparin. FITC-Heparin can be used for cell tracing and drug delivery.
Fluorescent Dye  
/
HY-32004 Coumalic acid
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity.
Parasite   Hydroxycarboxylic Acid Receptor (HCAR)   Endogenous Metabolite  
Parasitic Infection  
/
HY-126304R β-Glycerophosphate disodium salt hydrate (Standard)
β-Glycerophosphate disodium salt hydrate (Standard) is the analytical standard of β-Glycerophosphate disodium salt hydrate (HY-126304). This product is intended for research and analytical applications. β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
Reference Standards   ERK   Endogenous Metabolite   Phosphatase  
/
HY-W190740 dPEG(R)4-SATA
dPEG(R)4-SATA is a PEG derivative that can be used for drug delivery research, etc.
Biochemical Assay Reagents  
/
HY-P2217 Aclerastide
Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers.
Angiotensin Receptor  
Inflammation or Immune System Disease   Glucose Metabolism  
/
HY-P10886 Zifogaptide
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc.
Gap Junction Protein   Claudin  
Skin Inflammation  
/
HY-B2144J Chitosan (≥90% deacetylated,viscosity 650-700 mPa.s)
Chitosan (Deacetylated chitin) (≥90% deacetylated, viscosity 650-700 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated, viscosity 650-700 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
Environmental Pollutants   Fungal   Bacterial   Biochemical Assay Reagents  
Cancer   Infection  
/
HY-B1391R D-Panthenol (Standard)
D-Panthenol (Standard) is the analytical standard of D-Panthenol. This product is intended for research and analytical applications. D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.
Reference Standards   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-17389R Genipin (Standard)
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.
Reference Standards   Autophagy  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-121462 Cyanine
Cyanine is an excellent fluorescent core scaffold for constructing fluorescent probes. Covalent conjugation of Cyanine with other potent compounds can not only enhance their efficacy but also expand their application modes. Cyanine supports the development of cancer theranostic agents. Cyanine can be used in cancer research.
Fluorescent Dye  
Cancer  
/
HY-P2532 Integrin Binding Peptide
Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation.
Integrin  
/
HY-B2144I Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
Chitosan (Deacetylated chitin) (≥90% deacetylated,viscosity 10 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated,viscosity 10 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
Environmental Pollutants   Fungal   Bacterial   Biochemical Assay Reagents  
Cancer   Infection  
/
HY-P10956 Colulintide
Colulintide (LY3541105) is an amylin-calcitonin dual receptor agonist with Amylin as its scaffold. Colulintide is applicable to research related to type 2 diabetes and obesity.
Amylin Receptor   CGRP Receptor  
Type 2 Diabetes   Obesity  
/
HY-W110542D Poly(ethylene glycol) diacrylate (MW 1000)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 1000) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine.
Biochemical Assay Reagents  
/
HY-D1262 BODIPY-TS
BODIPY-TS (Thiol-green 2) is a fast response and thiol-specific turn-on probe. BODIPY-TS utilizes the thiosulfonate scaffold as a thiol recognition unit. BODIPY-TS has low toxicity, and features high selectivity, low detection limit, and quantitative reaction to thiols. Ex: 490 nM; Em: 515 nM.
Fluorescent Dye  
/
HY-P3386A Selcopintide acetate
Selcopintide (Cpne7-DP) acetate consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide acetate highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide acetate promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin.
Calcium Channel  
Metabolic or Endocrine Disease  
/
HY-20362 4-Azaindole
4-Azaindole is a scaffold. 4-Azaindole can be used in the synthesis of Nav1.2 inhibitors. 4-Azaindole can be used in epilepsy and breast cancer research.
Biochemical Assay Reagents   Drug Intermediate  
Neurological, Eye or Ear Disease   Breast Cancer  
/
HY-P11281A GYGGGP(GPP)5GFOGER(GPP)5GPC TFA
GYGGGP(GPP)5GFOGER(GPP)5GPC TFA is a type I collagen mimic that can bind to integrins and modify hydrogels.
Others  
Inflammation or Immune System Disease  
/
HY-D1005A2 Poloxamer 105 (L35)
Poloxamer 105 L35 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1900 Da. Poloxamer 105 L35 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-W339545A α-Ketoglutaric acid disodium hydrate
α-Ketoglutaric acid disodium hydrate, an important dicarboxylic acid, is an intermediate in the tricarboxylic acid cycle (TCC) and amino acid metabolism. α-Ketoglutaric acid disodium hydrate can be used as building block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions and wound healing compounds, or as main component of new elastomers with a wide range of interesting mechanical and chemical properties.
Biochemical Assay Reagents  
/
HY-120435 Tyrothricin
Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds.

Source: Bacillus brevis

Environmental Pollutants   Influenza Virus   Bacterial   Antibiotic   Fungal  
Viral Infection   Bacterial Infection   Fungal Infection  
/
HY-P2463 Fequesetide
Fequesetide, a peptide segment, is the active site within the protein thymosin β4 responsible for actin binding, cell migration and wound healing.
Arp2/3 Complex  
Inflammation or Immune System Disease  
/
HY-166979 Stearic acid-mPEG2000
Stearic acid-mPEG2000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG2000 can be used in drug delivery research.
Biochemical Assay Reagents  
/
HY-76562 Methyl 6-bromopicolinate
Methyl 6-bromopicolinate is a synthetic intermediate used in the preparation of γ-secretase inhibitor library scaffolds.
Biochemical Assay Reagents  
/
HY-N1198 Strictosamide
Strictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing.
Parasite   Fungal   NO Synthase   Interleukin Related   NF-κB   p38 MAPK   Na+/K+ ATPase   PERK   JNK   Akt   PI3K  
Lung Cancer   Breast Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Fungal Infection   Parasitic Infection   Depression   Pain   Digestive System Inflammation   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
/
HY-W145519A Hydroxyethyl starch (Mw 110-150 kDa)
Hydroxyethyl starch (Mw 110-150 kDa) is a biochemical reagent used in drug delivery and other research.
Biochemical Assay Reagents  
/
HY-W802699 α-Ketoglutaric acid disodium dihydrate
α-Ketoglutaric acid disodium dihydrate, an important dicarboxylic acid, is an intermediate in the tricarboxylic acid cycle (TCC) and amino acid metabolism. α-Ketoglutaric acid disodium dihydrate can be used as building block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions and wound healing compounds, or as main component of new elastomers with a wide range of interesting mechanical and chemical properties.
Biochemical Assay Reagents  
/
HY-P990130 Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain.

Species: Mouse/Rat

Transferrin Receptor  
Neurological, Eye or Ear Disease  
/
HY-116282I Dextran sulfate sodium salt (MW>500000)
Dextran sulfate sodium salt (MW>500000) (DSS (MW>500000)) is a negatively charged sulfated polysaccharide. Dextran sulfate sodium salt has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate sodium salt can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent.
HSV   SARS-CoV  
Inflammation or Immune System Disease  
/
HY-W110542N Poly(ethylene glycol) diacrylate (MW 250),MEHQ as inhibitor
Poly(ethylene glycol) diacrylate (PEGDA) (MW 250), MEHQ as inhibitor is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor can be used to construct optical cross-linked hydrogel implants.
Biochemical Assay Reagents  
/
HY-W110542J Poly(ethylene glycol) diacrylate (MW 700)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 700) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 700) mimics the extracellular matrix (ECM), providing support and growth space for cells.
Biochemical Assay Reagents  
/
HY-W110542P Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor
Poly(ethylene glycol) diacrylate (PEGDA) (MW 4000), MEHQ as inhibitor is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor can be used to construct enzyme-responsive hydrogel drug delivery system.
Biochemical Assay Reagents  
/
HY-P6022 G4RGDSP, integrin-binding peptide
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology
Integrin  
/
HY-116282M Dextran sulfate, low sulfate (MW 40000)
Dextran sulfate, low sulfate (MW 40000), a biopolymer, is a sulfated polysaccharide. Dextran sulfate, low sulfate (MW 40000) has antiviral, antibacterial, anti-inflammatory, antifibrotic, and wound-healing properties. Dextran sulfate can be used as an additive in cell culture media for preventing cell aggregation and in cosmetics as a gel-forming agent.
Bacterial  
Inflammation or Immune System Disease  
/
HY-W041988 Fmoc-Glu-OMe
Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO3) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds.
Bacterial  
Staphylococcus Aureus Infection   Escherichia Coli Infection   Pseudomonas Aeruginosa Infection  
/
HY-P990282 Anti-Mouse CD24 Antibody (M1/69)
Anti-Mouse CD24 Antibody (M1/69) is a rat-derived anti-mouse CD24 IgG2b κ type antibody inhibitor. Anti-Mouse CD24 Antibody reduces heat stable antigen (HSA) expression level and delays wound healing in Wild-type HSA+/+ mice.

Species: Mouse

Transmembrane Glycoprotein  
Cancer  
/
HY-125870 Gellan gum, for cell culture
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations.
Environmental Pollutants   Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-P1771A OVA G4 peptide TFA
OVA G4 peptide TFA is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-P10294 Oligopeptide P11-4
Oligopeptide P11-4 is an α-peptide that can be self-assembled into β-sheet amyloids with a hydrogel appearance at low pH. Oligopeptide P11-4 can be used in biomimetic mineralization, enamel regeneration and oral care agent.
Amyloid-β  
/
HY-W763582B GelMA, 90% methacrylation
GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing.
Biochemical Assay Reagents  
/
HY-P990049 Becotatug
Becotatug (JMT-101) is a humanized IgG1 monoclonal antibody targeting epidermal growth factor receptor (EGFR), and serves as the antibody component of the antibody-drug conjugate Becotatug vedotin (HY-171265). Becotatug specifically binds to the extracellular domain of EGFR, induces receptor internalization and degradation, blocks the EGFR signaling pathway, and mediates antibody-dependent cellular cytotoxicity. When conjugated to monomethyl auristatin E (MMAE) (HY-15162) via a valine-citrulline cleavable linker, Becotatug enables targeted delivery of cytotoxic drugs to EGFR-positive tumor cells. Becotatug can be used for research related to non-small cell lung cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma..

Species: Human

EGFR   ADC Antibodies  
Non-Small Cell Lung Cancer   Nasopharyngeal Cancer  
/
HY-W250313 Polylactic acid
Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds.
Biochemical Assay Reagents  
Cancer  
/
HY-Y0519 Pyrimidine
Pyrimidine is a nitrogen-containing heterocyclic compound that serves as a scaffold for numerous natural and synthetic derivatives. As a pharmacophore, pyrimidine interacts with the synthesis and function of nucleic acids. Pyrimidine derivatives are used in research related to pancreatic cancer, triple-negative breast cancer, colon cancer, and leukemia.
Endogenous Metabolite  
Breast Cancer   Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer  
/
HY-132187 Sphingosylphosphorylcholine
Sphingosylphosphorylcholine is a bioactive lipid and a major component of plasma high-density lipoprotein that binds to OGR1 with a Kd of 33.3 nM. Sphingosylphosphorylcholine triggers delayed phosphorylation of Smad2, upregulates α-SMA expression, and activates TRPM3. Sphingosylphosphorylcholine reduces Apoptosis and upregulates the expression of uPA and its receptor uPA-R. Sphingosylphosphorylcholine exerts anti-apoptotic, anti-cardiac hypertrophy and pro-wound healing effects. Sphingosylphosphorylcholine induces scratching behavior in mice. Sphingosylphosphorylcholine is used in studies related to atopic dermatitis, promyelocytic leukemia, heart failure, myocardial ischemia/reperfusion injury, ovarian cancer, breast cancer, pancreatic cancer, and skin wound healing disorders in genetically impaired healing diabetes.
TGF-beta/Smad   TRP Channel   Apoptosis   PAI-1  
Breast Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Glucose Metabolism   Atopic Dermatitis   Ischemia-Reperfusion Injury   Heart Failure  
/
HY-P5557 TP4 (Nile tilapia piscidin)
TP4 (Nile tilapia piscidin) is an orally active amphipathic α-helical cationic antimicrobial peptide. TP4 (Nile tilapia piscidin) exerts broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria by disrupting cell membrane structures, and also exhibits certain hemolytic activity. TP4 (Nile tilapia piscidin) regulates the innate immune system and enhances the expression of lysozymes, cytokines and antioxidant enzymes to resist bacterial infection. TP4 (Nile tilapia piscidin) also stimulates the proliferation of keratinocytes and fibroblasts, and significantly promotes the healing of wounds infected with MRSA. TP4 (Nile tilapia piscidin) can be used in research related to bacterial infection, peritonitis, wound healing and other fields.
Bacterial   Necroptosis  
Inflammation or Immune System Disease   Bacterial Infection  
/
HY-N2551 Vitamin U chloride
Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration.
Others  
Inflammation or Immune System Disease  
/
HY-105174A BPC 157 acetate
BPC 157 acetate is an orally active peptide. BPC 157 acetate exhibits multiple activities such as promoting wound healing, tendon healing, neuroprotection, and gastrointestinal protection. BPC 157 acetate can be used in the research of tendon injury, burn, gastric ulcer, and neurological diseases.
JAK   FAK  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-Y0191 α-Pyridone
α-Pyridone (2-Pyridone) is an antibacterial agent that plays an important role in the field of biochemical research. α-Pyridone can serve as a scaffold compound to synthesize a variety of active compounds.
Endogenous Metabolite   Bacterial  
Bacterial Infection  
/
HY-W006371 (2-Aminoethyl)phosphonic acid
(2-Aminoethyl)phosphonic acid is an endogenous metabolite and amino acid analog. (2-Aminoethyl)phosphonic acid can be used for the synthesis of biological macromolecules and the preparation of hydrogels.
Endogenous Metabolite   Drug Intermediate  
Metabolic or Endocrine Disease  
/
HY-W019682 Fmoc-FF
Fmoc-FF is a building block. Fmoc-FF-prepared hydrogels and nanogels selectively deliver Dexamethasone (HY-14648) to leukemia cells.
Biochemical Assay Reagents  
Leukemia/Lymphoma/Myeloma  
/
HY-77817 Pyrrole-2-carboxaldehyde
Pyrrole-2-carboxaldehyde (2-Formylpyrrole) is a heterocyclic organic compound that serves as a scaffold for the synthesis of various bioactive compounds.
Drug Intermediate  
/
HY-N6613 Polygalacturonic acid
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.
Others  
Inflammation or Immune System Disease  
/
HY-P3159 VPM peptide
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel.
Biochemical Assay Reagents  
/
HY-W763582A GelMA, 60% methacrylation
GelMA (Gelatin Methacryloyl), 60% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing.
Biochemical Assay Reagents  
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HY-W763582 GelMA, 30% methacrylation
GelMA (Gelatin Methacryloyl), 30% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing.
Biochemical Assay Reagents  
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HY-W110542G Poly(ethylene glycol) diacrylate (MW 6000)
Poly(ethylene glycol) diacrylate (PEGDA) (MW 6000) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 6000) can be used as a building material for wound dressing hydrogels.
Biochemical Assay Reagents  
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HY-156829B PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1)
PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) is a biodegradable thermosensitive hydrogel product that can undergo phase transition at a specific temperature. PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) can be widely used in drug delivery systems, tissue engineering, wound dressings, and biosensors. The gelation temperature varies with concentration. The gelation temperature varies with the concentration; the higher the concentration, the lower the gelation temperature.
Biochemical Assay Reagents  
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HY-P990132 Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human CD47/IAP IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair.

Species: Human/Mouse/Rat

CD47  
Inflammation or Immune System Disease   Breast Cancer  
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HY-P5558 KLTWQELYQLKYKGI
KLTWQELYQLKYKGI is a VEGF mimetic peptide designed based on the VEGF helix sequence 17-25, with the ability to activate VEGF receptors and exert pro-angiogenic biological activity. KLTWQELYQLKYKGI effectively promotes the attachment, spreading and proliferation of human umbilical vein endothelial cells. KLTWQELYQLKYKGI enhances the proliferation, migration and osteogenic differentiation of bone marrow stromal cells (BMSCs). KLTWQELYQLKYKGI synergistically accelerates angiogenesis and bone regeneration in rat cranial defect models. KLTWQELYQLKYKGI can be used for the research of brain tissue engineering and traumatic brain injury repair and biomaterials for bone tissue engineering and bone repair.
VEGFR  
Neurological, Eye or Ear Disease  
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HY-153126 Yeast extract
Yeast extract is a concentrate of the soluble components of yeast, especially Saccharomyces cerevisiae. Yeast extract is rich in nutritional components such as partially hydrolyzed proteins, free amino acids, B vitamins, and minerals. As a food ingredient, Yeast extract has both nutritional and flavoring properties. Yeast extract can also promote wound healing.
Biochemical Assay Reagents   Bacterial  
Infection   Metabolic or Endocrine Disease  
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HY-W110584 Carboxybetaine methacrylate
Carboxybetaine methacrylate is an amphoteric ionic compound with excellent properties such as good hydrophilicity, antistatic property, and biocompatibility. Carboxybetaine methacrylate can be used to prepare tissue engineering scaffolds, drug carriers, and so on.
Biochemical Assay Reagents  
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HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery.
Biochemical Assay Reagents  
Cancer  
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HY-Y0775 1-Bromo-2,5-pyrrolidinedione
1-Bromo-2,5-pyrrolidinedione is a collagen protein ligand in docking experiments. 1-Bromo-2,5-pyrrolidinedione can be used to study wound healing-related diseases.
Biochemical Assay Reagents   Collagen  
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HY-P70931 MAPKSP1 Protein, Human (His)
The MAPKSP1 protein, also known as porphobilinogen deaminase (HMBS), is crucial in the heme biosynthetic pathway and catalyzes the sequential polymerization of four porphobilinogen molecules to form hydroxymethyl bixane. The process begins with the assembly of the dipyrromethane cofactor of porphobilinogen or preuroporphyrinogen. MAPKSP1 Protein, Human (His) is the recombinant human-derived MAPKSP1 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P703113 DLG4 Protein, Human (Biotinylated, HEK293)
DLG4 Protein, Human (Biotinylated, HEK293) is the recombinant human-derived DLG4, expressed by HEK293 , with tag Free labeled tag.

Species: Human; Source: HEK293

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HY-P703114 DLG4 Protein, Human (Biotinylated, Avi)
DLG4 Protein, Human (Biotinylated, Avi) is the recombinant human-derived DLG4, expressed by E. coli , with Avi labeled tag.

Species: Human; Source: E. coli

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HY-P703453 D13 Protein, Monkeypox virus (His, Strep)
D13 Protein, Monkeypox virus (His, Strep) is the recombinant virus-derived D13, expressed by E. coli , with Strep, His labeled tag.

Species: Virus; Source: E. coli

Viral Proteins

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HY-P71010 PSD95 Protein, Rat (His)
PSD95 protein plays a crucial role in PDZ domain binding, enzyme binding and signaling receptor binding. It is a structural component of the postsynaptic density and is involved in the regulation of synaptic transmission and cellular organization. PSD95 Protein, Rat (His) is the recombinant rat-derived PSD95 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Rat; Source: E. coli

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HY-P705527 Homer1 Protein, Human (His)

Species: Human; Source: E. coli

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HY-P81279 hnRNP U Antibody (YA979)
hnRNP U Antibody (YA979) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to hnRNP U.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P810828 BANP Antibody (YA10071)
BANP Antibody (YA10071) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to BANP.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P812026 ECPAS Antibody(YA10497)
ECPAS Antibody(YA10497) is a Mouse-derived and non-conjugated IgG2a recombinant monoclonal antibody, targeting to ECPAS.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P812026A ECPAS Antibody(YA10497) (PBS only)
ECPAS Antibody(YA10497) is a Mouse-derived and non-conjugated IgG2a recombinant monoclonal antibody, targeting to ECPAS.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81279A hnRNP U Antibody (YA980)
hnRNP U Antibody (YA980) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hnRNP U.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81306 SAFB1 Antibody (YA1042)
SAFB1 Antibody (YA1042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SAFB1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P81306A SAFB1 Antibody (YA1043)
SAFB1 Antibody (YA1043) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAFB1.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81434 BANK1 Antibody (YA1179)
BANK1 Antibody (YA1179) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BANK1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81434A BANK1 Antibody (YA1179)(PBS only)
BANK1 Antibody (YA1179) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BANK1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85435 hnRNP U Antibody (YA5127)
hnRNP U Antibody (YA5127) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to hnRNP U.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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Keywords

cryogel | wound healing | macroporous hydrogel | antimicrobial dressing | drug delivery | tissue regeneration | inflammation modulation | scaffold