2. Gene
  3. Stat3 - signal transducer and activator of transcription 3 Gene

Stat3 - signal transducer and activator of transcription 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Aprf; 1110034C02Rik

Gene ID: 20848 | Gene type: protein coding

About Stat3

Chromosome 11: 100,775,924-100,830,366 reverse strand.GRCm39:CM001004.3

This gene has 14 transcripts (splice variants), 133 orthologues, 6 paralogues and is associated with 21 phenotypes. Ubiquitous expression in lung adult (RPKM 48.1), mammary gland adult (RPKM 46.4) and 28 other tissues.

Summary

The protein encoded by this gene is a member of the STAT protein family. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various Cytokines and Growth Factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and Apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Stat3 Products(3)

mRNA Protein Name
NM_213659.3 NP_998824.1 signal transducer and activator of transcription 3 isoform 1
NM_213660.3 NP_998825.1 signal transducer and activator of transcription 3 isoform 2
NM_011486.5 NP_035616.1 signal transducer and activator of transcription 3 isoform 3

Stat3 Protein Structure

STAT_int

STAT_int: smart00964 (1 - 119)

STAT3_CCD

STAT3_CCD: cd16853 (138 - 317)

STAT3_DBD

STAT3_DBD: cd16847 (320 - 483)

SH2_STAT3

SH2_STAT3: cd10374 (553 - 714)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 3

acute phase response factor

Related Agents

Approval
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14944 Homoharringtonine Inhibitor 99.96% Yes
HY-B0497 Niclosamide Inhibitor 99.90% Yes
HY-N0193 Artesunate Inhibitor 98.09% Yes
HY-B2163 Astaxanthin Inhibitor ≥98.0% Unkown
HY-12987 Pimozide Inhibitor 99.88% Yes
HY-B1436 Nifuroxazide Inhibitor 99.36% Unkown
HY-B0294 Flubendazole Inhibitor 99.33% Yes
HY-B0130A Perindopril erbumine 99.98% Yes
HY-17015A Peramivir 98.19% Unkown
HY-B0667 Balsalazide Inhibitor 99.34% Yes
HY-B0667A Balsalazide sodium hydrate Inhibitor 99.61% Yes
HY-B0497B Niclosamide monohydrate Inhibitor / Unkown
HY-B0130 Perindopril 98.01% Yes
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-12987S Pimozide-d4 Inhibitor ≥98.0% Phase 4
HY-16141 Cilengitide Inhibitor 99.80% Phase 3
HY-13919 Napabucasin Inhibitor 98.85% Phase 3
HY-14743B Golotimod hydrochloride Inhibitor 99.79% Phase 2
HY-14743 Golotimod Inhibitor 98.04% Phase 2
HY-14743A Golotimod TFA Inhibitor / Phase 2
HY-112288 C188-9 Inhibitor 99.90% Phase 1
HY-15312 WP1066 Inhibitor 99.77% Phase 1
HY-13326 ASP3026 99.73% Phase 1
Pre-clinical Phase
Bioactive Molecules (70)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13818 Stattic Inhibitor 99.60% Unkown
HY-12000 AG490 Inhibitor 99.97% Unkown
HY-10074 TPCA-1 Inhibitor 99.72% Unkown
HY-P1061A Colivelin TFA Activator 99.52% Unkown
HY-15146 NSC 74859 Inhibitor 98.64% Unkown
HY-148748 Butyzamide Activator 99.62% Unkown
HY-N0174 Cryptotanshinone Inhibitor 98.69% Unkown
HY-N0751 Scutellarin Inhibitor 98.56% Unkown
HY-129602 SD-36 Inhibitor 98.52% Unkown
HY-N0250 Saikosaponin D Inhibitor 98.76% Unkown
HY-N0177 Diosgenin Inhibitor 99.20% Unkown
HY-N1405 Cucurbitacin I Inhibitor 99.44% Unkown
HY-P1061 Colivelin Activator 99.27% Unkown
HY-100493 BP-1-102 Inhibitor 99.52% Unkown
HY-16975 SH-4-54 Inhibitor 99.45% Unkown
HY-N0038 Alantolactone Inhibitor 99.94% Unkown
HY-N0622 Morusin Inhibitor 99.94% Unkown
HY-129603 SI-109 Inhibitor 99.91% Unkown
HY-136657 SC-43 Inhibitor 99.02% Unkown
HY-100602 HJC0152 Inhibitor 98.92% Unkown
HY-122258 NSC-370284 Inhibitor 96.02% Unkown
HY-N6953 Garcinone D Activator 99.88% Unkown
HY-N2959 Brevilin A Inhibitor 99.71% Unkown
HY-100453 HO-3867 Inhibitor 99.39% Unkown
HY-N2963 Broussonin E Activator 98.18% Unkown
HY-N2312 Mogrol Inhibitor 99.25% Unkown
HY-N0897 Corylifol A Inhibitor 99.90% Unkown
HY-128588 STAT3-IN-3 Inhibitor 98.23% Unkown
HY-18061 Ochromycinone Inhibitor 98.29% Unkown
HY-103692 STX-0119 Inhibitor 99.21% Unkown
HY-115594 Erasin Inhibitor 95.03% Unkown
HY-103128 inS3-54A18 Inhibitor 99.53% Unkown
HY-120395 UC-514321 Inhibitor ≥98.0% Unkown
HY-N6954 Garcinone C Inhibitor 99.66% Unkown
HY-N1356 Reticuline Inhibitor 98.91% Unkown
HY-148692 OSM-SMI-10B Inhibitor 99.28% Unkown
HY-150538 STAT3-IN-12 Inhibitor 99.92% Unkown
HY-113573 Protosappanin A 99.98% Unkown
HY-100494 SH5-07 Inhibitor ≥98.0% Unkown
HY-151976 STAT3-IN-15 Inhibitor 98.99% Unkown
HY-N2521 Tetramethylcurcumin Inhibitor 99.91% Unkown
HY-124858 SC99 Inhibitor 98.96% Unkown
HY-N6843 Arnicolide D Inhibitor 99.20% Unkown
HY-16196 ENMD-1198 Inhibitor 98.87% Unkown
HY-136658 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Inhibitor 98.02% Unkown
HY-151634 Syk-IN-6 Inhibitor / Unkown
HY-148706 STAT3-IN-17 Inhibitor ≥98.0% Unkown
HY-P5314 OK2 Inhibitor 95.95% Unkown
HY-P2282 APTSTAT3-9R Inhibitor 99.55% Unkown
HY-112391 SD-1029 Inhibitor / Unkown
HY-12352A HJC0416 hydrochloride Inhibitor / Unkown
HY-N9561 Vanicoside B Inhibitor / Unkown
HY-144871 STAT3-IN-8 Inhibitor / Unkown
HY-163176 WB518 Inhibitor / Unkown
HY-146728 STAT3-IN-10 Inhibitor / Unkown
HY-153023 PROTAC STAT3 degrader-2 Degrader / Unkown
HY-147187 MNK8 Inhibitor 99.76% Unkown
HY-138071 8α-Tigloyloxyhirsutinolide 13-O-acetate Inhibitor / Unkown
HY-161351 STAT3/AKT-IN-1 Inhibitor / Unkown
HY-112447 STAT3-IN-5 Inhibitor / Unkown
HY-N11501 7-epi-Isogarcinol Inhibitor / Unkown
HY-125170 Galiellalactone Inhibitor / Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-149257 HAT-SIL-TG-1&AT Inhibitor / Unkown
HY-12352 HJC0416 Inhibitor / Unkown
HY-146666 STAT3-IN-9 Inhibitor / Unkown
HY-P10201 Ac-GpYLPQTV-NH2 Inhibitor / Unkown
HY-N3913 Furowanin A Inhibitor / Unkown
HY-149700 ROCK2-IN-7 / Unkown
HY-107595 SD-1008 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99917 Eflepedocokin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat3 NCBI NCBI:6774