MB - myoglobin Gene
Also Known as PVALB
Species: Homo sapiens
About MB
This gene has 10 transcripts (splice variants), 207 orthologues and 11 paralogues. Restricted expression toward heart (RPKM 2708.0).
Summary
This gene encodes a member of the globin superfamily and is predominantly expressed in skeletal and cardiac muscles. The encoded protein forms a monomeric globular haemoprotein that is primarily responsible for the storage and facilitated transfer of oxygen from the cell membrane to the mitochondria. This protein also plays a role in regulating physiological levels of nitric oxide. Multiple transcript variants encoding distinct isoforms exist for this gene. [provided by RefSeq, May 2020]
MB Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001362846.2 | NP_001349775.1 | myoglobin isoform 1 |
| NM_001382809.1 | NP_001369738.1 | myoglobin isoform 1 |
| NM_001382810.1 | NP_001369739.1 | myoglobin isoform 1 |
| NM_001382811.1 | NP_001369740.1 | myoglobin isoform 1 |
| NM_001382812.1 | NP_001369741.1 | myoglobin isoform 2 |
| NM_001382813.1 | NP_001369742.1 | myoglobin isoform 2 |
| NM_005368.3 | NP_005359.1 | myoglobin isoform 1 |
| NM_203377.1 | NP_976311.1 | myoglobin isoform 1 |
| NM_203378.1 | NP_976312.1 | myoglobin isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables nitrite reductase activity |
IDA
IDA: Inferred from direct assay
|
32891753 | GOA |
| enables oxygen carrier activity |
IMP
IMP: Inferred from mutant phenotype
|
30918256 | GOA |
| enables peroxidase activity |
IDA
IDA: Inferred from direct assay
|
34679218 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28514442 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in removal of superoxide radicals |
IDA
IDA: Inferred from direct assay
|
34679218 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in sarcoplasm |
IDA
IDA: Inferred from direct assay
|
30918256 | GOA |
MB Protein Structure
Globin: Globin (7 - 112)
- 0
- 100
- 154 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myoglobin |
|
Recombinant MB Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70243 | Myoglobin Protein, Human (His) | P02144 (M1-G154) | ≥ 95%, as determined by reducing SDS-PAGE. |
MB Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81253 | Myoglobin Antibody (YA925) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P81430 | Myoglobin Antibody (YA1175) | IHC-P | Human |
| HY-P81430A | Myoglobin Antibody (YA1175)(PBS only) | IHC-P | Human |
| HY-P85922 | Myoglobin Antibody (YA5614) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Compartment Syndrome |
|
|
| Acute Kidney Tubular Necrosis |
|
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| Myxosarcoma |
|
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| Neuroleptic Malignant Syndrome |
|
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| Alveolar Soft Part Sarcoma |
|
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| Acute Kidney Failure |
|
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| Acute Myocardial Infarction |
|
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| Medullomyoblastoma |
|
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| Myoglobinuria |
|
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| Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration |
|
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| Leiomyosarcoma |
|
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| Disseminated Intravascular Coagulation |
|
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| Orbit Embryonal Rhabdomyosarcoma |
|
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| Anuria |
|
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| Granular Cell Leiomyosarcoma |
|
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| Angina Pectoris |
|
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| Myositis |
|
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| Ischemia |
|
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| Malignant Hyperthermia |
|
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| Plantar Fascial Fibromatosis |
|
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| Rhabdomyosarcoma |
|
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| Myocardial Infarction |
|
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| Embryonal Rhabdomyosarcoma |
|
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| Adenosarcoma |
|
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| Polymyositis |
|
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| Liposarcoma |
|
|
| Rhabdomyosarcoma 2 |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Lipoprotein Quantitative Trait Locus |
|
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| Myocarditis |
|
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| Gas Gangrene |
|
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| Pyomyositis |
|
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| Hemoglobinuria |
|
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| Breast Leiomyosarcoma |
|
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| Malignant Mesenchymoma |
|
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| Malignant Fibrous Histiocytoma |
|
|
| Botryoid Rhabdomyosarcoma |
|
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| Thymus Lipoma |
|
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| Immune System Organ Benign Neoplasm |
|
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| Anterior Compartment Syndrome |
|
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| Blastoma |
|
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| Orbit Rhabdomyosarcoma |
|
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| Carcinosarcoma |
|
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| Pulmonary Embolism |
|
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| Peroneal Nerve Paralysis |
|
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| Malignant Triton Tumor |
|
|
| Fallopian Tube Papillary Adenocarcinoma |
|
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| Skeletal Muscle Neoplasm |
|
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| Sulfhemoglobinemia |
|
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| Mediastinal Lipomatosis |
|
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| Malaria |
|
|
| Blackwater Fever |
|
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| Femoral Neuropathy |
|
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| Interstitial Myocarditis |
|
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| Myopathy |
|
|
| Anteroseptal Myocardial Infarction |
|
|
| Sarcoma |
|
|
| Breast Rhabdomyosarcoma |
|
|
| Toxoplasmosis |
|
|
| Tetanus |
|
|
| Skeletal Muscle Cancer |
|
|
| Ornithosis |
|
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| Angiomyoma |
|
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| Malignant Granular Cell Myoblastoma |
|
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| Rheumatic Myocarditis |
|
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| Peroneal Neuropathy |
|
|
| Glycogen Storage Disease V |
|
|
| Deficiency Anemia |
|
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| Muscle Cancer |
|
|
| Uterine Carcinosarcoma |
|
|
| Gallbladder Leiomyosarcoma |
|
|
| Neuromuscular Disease |
|
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| Ectopic Pregnancy |
|
|
| Creatine Phosphokinase, Elevated Serum |
|
|
| Cardiac Arrest |
|
|
| Renal Pelvis Squamous Cell Carcinoma |
|
|
| Methemoglobinemia |
|
|
| Intermediate Coronary Syndrome |
|
|
| Corneal Dystrophy, Subepithelial Mucinous |
|
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| Pericardium Disease |
|
|
| Ceftriaxone Allergy |
|
|
| Heart Disease |
|
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| Hypokalemia |
|
|
| Dilated Cardiomyopathy |
|
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| Muscular Disease |
|
|
| Critical Illness Polyneuropathy |
|
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| Muscle Tissue Disease |
|
|
| Isolated Elevated Serum Creatine Phosphokinase Levels |
|
|
| Muscular Dystrophy |
|
|
| Muscular Dystrophy, Duchenne Type |
|
|
| Porphyria, Acute Intermittent |
|
|
| Plexopathy |
|
|
| Variegate Porphyria |
|
|
| Coronary Artery Vasospasm |
|
|
| Pericardial Effusion |
|
|
| Prostate Embryonal Rhabdomyosarcoma |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Uterine Sarcoma |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Corneal Dystrophy, Posterior Polymorphous, 2 |
|
|
| Lung Clear Cell Carcinoma |
|
|
| Hemoglobinopathy |
|
|
| Vulvar Proximal-Type Epithelioid Sarcoma |
|
|
| Central Epithelioid Sarcoma |
|
|
| Cardiovascular System Disease |
|
|
| Hypermethioninemia Due To Adenosine Kinase Deficiency |
|
|
| Lipid Metabolism Disorder |
|
|
| Sodoku Disease |
|
|
| Retinitis Pigmentosa 7 |
|
|
| Stroke, Ischemic |
|
|
| Hemochromatosis, Type 1 |
|
|
| Hypertension, Essential |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | MB | VGNC | VGNC:31270 |
| Canis familiaris | MB | VGNC | VGNC:43046 |
| Macaca mulatta | MB | VGNC | VGNC:74668 |
| Rattus norvegicus | MB | RGD | RGD:620411 |
| Mus musculus | MB | MGD | MGI:96922 |
| Others | MB | NCBI |