Ager - advanced glycosylation end product-specific receptor Gene

Also Known as RAGE

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81722

Summary

Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including bone disease (multiple); cardiovascular system disease (multiple); colorectal carcinoma; diabetic encephalopathy; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ager Products (1)

mRNA	Protein	Name
NM_053336.2	NP_445788.2	advanced glycosylation end product-specific receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables S100 protein binding	IPI IPI: Inferred from physical interaction	19910580	RGD
enables high mobility group box 1 binding	IPI IPI: Inferred from physical interaction	22740883	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7592757	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	11180401	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	22217518	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	20054520	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19885844	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	21807062	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	22467055	RGD
involved in glycoprotein metabolic process	IEP IEP: Inferred from expression pattern	23348924	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	17343756	RGD
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	22301267	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	21872885	RGD
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	22301267	RGD
involved in negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	22301267	RGD
involved in negative regulation of osteoblast proliferation	IEP IEP: Inferred from expression pattern	23529231	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21743278	RGD
involved in neuron projection development	IGI IGI: Inferred from genetic interaction	7592757	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	7592757	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19910580	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22293957	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19380826	RGD
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22301267	RGD
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	21743278	RGD
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	19959167	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	23053478	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21111711	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22717618	RGD
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	23238794	RGD
involved in positive regulation of potassium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23212096	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19885844	RGD
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19885844	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	23212096	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16368901	RGD
involved in positive regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21111711	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	23285277	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	21704028	RGD
involved in response to genistein	IEP IEP: Inferred from expression pattern	21704028	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	17343756	RGD
involved in response to methylglyoxal	IEP IEP: Inferred from expression pattern	22425979	RGD
involved in response to selenite ion	IEP IEP: Inferred from expression pattern	22476978	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	22274401	RGD
involved in transdifferentiation	IEP IEP: Inferred from expression pattern	23403079	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	7592757	RGD
located in basal plasma membrane	IDA IDA: Inferred from direct assay	9846897	RGD
located in cell surface	IDA IDA: Inferred from direct assay	17959934	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16456142	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	7592757	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
advanced glycosylation end product-specific receptor	receptor for advanced glycosylation end products

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0146	Verteporfin		99.58%	Yes
HY-16561	Resveratrol		99.95%	Yes
HY-147080	Avacincaptad pegol sodium	Inhibitor	94.64%	Unkown
HY-B0167A	Sodium Salicylate		99.99%	Yes
HY-W012382	N-Acetyl-L-tyrosine		99.48%	Unkown
HY-109561	Pegaptanib sodium	Inhibitor	90.51%	Unkown
HY-17549	Adrafinil	Agonist	99.85%	Unkown
HY-148457	Avacincaptad pegol	Inhibitor	92.50%	Unkown
HY-B0897	Bisoctrizole		98.0%	Unkown
HY-14892	Gemigliptin	Inhibitor	/	Unkown
HY-13995	Sevelamer	Inhibitor	/	Unkown
HY-185390	Verteporfin liposome	Inhibitor	/	Unkown
HY-B0146R	Verteporfin (Standard)		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108801	Aflibercept	Inhibitor	97.90%	Unkown
HY-P99116	Faricimab	Inhibitor	97.97%	Unkown

Clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W004260	Arachidic acid		99.94%	Phase 4
HY-N0160	Kinetin		99.76%	Phase 4
HY-I0626	Cytosine		99.99%	Phase 4
HY-P3252A	Pegcetacoplan acetate	Inhibitor	99.92%	Phase 3
HY-W013494	L-Carnosine		99.95%	Phase 3
HY-106024B	Alagebrium chloride	Inhibitor	99.82%	Phase 3
HY-B1745	Pyridoxylamine		99.91%	Phase 3
HY-19720A	Emixustat hydrochloride	Inhibitor	99.29%	Phase 3
HY-19720	Emixustat		98.00%	Phase 3
HY-116098	Anecortave desacetate		98.36%	Phase 3
HY-109118A	Masupirdine mesylate	Antagonist	99.62%	Phase 3
HY-109118	Masupirdine free base	Antagonist	/	Phase 3
HY-153484	Bevasiranib	Inhibitor	/	Phase 3
HY-112499	Menaquinone-7	Activator	98.51%	Phase 2
HY-128850	N-Acetyl-D-mannosamine		99.99%	Phase 2
HY-128973	Pyropheophorbide-a		98.0%	Phase 2
HY-P3204	POT-4	Inhibitor	98.88%	Phase 2
HY-132806	Alogabat	Agonist	99.93%	Phase 2
HY-P5285	Lunasin	Inhibitor	98.22%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-W250163	NAD+ lithium		99.49%	Phase 2
HY-W701069	Isomyosmine		97.38%	Phase 2
HY-112499R	Menaquinone-7 (Standard)		98.27%	Phase 2
HY-153484A	Bevasiranib sodium	Inhibitor	97.68%	Phase 2
HY-177668A	Umedaptanib pegol sodium	Inhibitor	/	Phase 2
HY-136788A	ALK4290 dihydrochloride	Inhibitor	/	Phase 2
HY-14564	GTS-21	Agonist	/	Phase 2
HY-150177	Mannose 6 phosphate		/	Phase 2
HY-177668	Umedaptanib pegol	Inhibitor	/	Phase 2
HY-P1930	Risuteganib	Inhibitor	/	Phase 2
HY-P3204A	POT-4 TFA	Inhibitor	/	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-B1041	Aminoguanidine hydrochloride		≥98.0%	Phase 1
HY-W050154	Kojic acid	Inhibitor	99.99%	Phase 1
HY-N1420A	Rhamnose monohydrate		99.95%	Phase 1
HY-15114	S 17092	Inhibitor	99.78%	Phase 1
HY-137557	Florzolotau	Ligand	/	Phase 1
HY-16387	PF 00337210	Inhibitor	/	Phase 1
HY-19692	Itasetron	Antagonist	/	Phase 1

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108801A	Aflibercept (VEGF Trap)	Inhibitor	97.66%	Phase 4
HY-P99576	Tarcocimab	Inhibitor	98.35%	Phase 3
HY-P99298	Lampalizumab	Inhibitor	99.46%	Phase 3
HY-P991416	BAT5906	Inhibitor	/	Phase 3
HY-P991418	MW02	Inhibitor	/	Phase 3
HY-P99629	Galegenimab	Inhibitor	99.91%	Phase 2
HY-P991535	PMN310	Inhibitor	/	Phase 1
HY-P991415	ASKG-712	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (355)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112879	Mito-TEMPO		99.19%	Unkown
HY-N0088	Apocynin	Inhibitor	99.94%	Unkown
HY-131042	NNMTi	Inhibitor	99.70%	Unkown
HY-N1485	Cycloastragenol	Activator	98.0%	Unkown
HY-N0664	Aucubin	Inhibitor	99.98%	Unkown
HY-12688A	Succinyl phosphonate trisodium salt	Inhibitor	98.0%	Unkown
HY-120912	Gingerenone A	Activator	99.95%	Unkown
HY-N0568	Madecassoside		99.58%	Unkown
HY-N0033	Poliumoside	Inhibitor	99.69%	Unkown
HY-147313	TH10785	Activator	99.93%	Unkown
HY-103157	PD146176		99.59%	Unkown
HY-NP165	Advanced glycation end products		/	Unkown
HY-W250118	Cephalin form bovine brain	Activator	98.0%	Unkown
HY-16561R	Resveratrol (Standard)		99.95%	Unkown
HY-W015924	2-Hydroxyisobutyric acid		98.0%	Unkown
HY-P0033	Argireline	Inhibitor	99.86%	Unkown
HY-N0295	Protocatechualdehyde	Inhibitor	99.92%	Unkown
HY-N1420	Rhamnose		99.35%	Yes
HY-125623	MitoPerOx		97.41%	Unkown
HY-402361	TERT activator-1		99.91%	Unkown
HY-147059	Dieckol		99.20%	Unkown
HY-126255	SBI-797812	Activator	99.88%	Unkown
HY-W001083	3-Hydroxyphenylacetic acid		99.77%	Unkown
HY-N2072	Crocetin	Inhibitor	98.07%	Unkown
HY-N5135	Liriopesides B		99.92%	Unkown
HY-P2048	MOTS-c (human)		99.90%	Unkown
HY-125944	MitoTEMPO hydrate		98.03%	Unkown
HY-129460	XJB-5-131	Inhibitor	99.9%	Unkown
HY-N2026	Propylparaben		99.96%	Unkown
HY-N9914	D-Psicose	Inhibitor	99.99%	Unkown
HY-11068	SB 239063	Inhibitor	99.49%	Unkown
HY-129380	Fructosyl-lysine		99.86%	Unkown
HY-120380	FeTMPyP	Inhibitor	99.98%	Unkown
HY-P1928	Humanin	Inhibitor	99.73%	Unkown
HY-P2048A	MOTS-c(human) acetate	Activator	99.74%	Unkown
HY-W337672	H-Pro-Hyp-OH		99.0%	Unkown
HY-W003607	3-O-Ethyl-L-ascorbic acid	Inhibitor	99.94%	Unkown
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-159062	Goji Extract	Activator	/	Unkown
HY-P1149	Epitalon	Activator	99.63%	Yes
HY-107811	Harmol		99.81%	Unkown
HY-133968	24-Methylenecholesterol		99.78%	Unkown
HY-N0012	Glycitin	Inhibitor	99.71%	Unkown
HY-N2484	Methylnissolin	Inhibitor	99.92%	Unkown
HY-150069	UBX1325		99.16%	Unkown
HY-136093A	Lixumistat acetate		99.88%	Unkown
HY-P1149A	Epitalon TFA	Activator	99.46%	Unkown
HY-N2292	Kinsenoside		99.92%	Unkown
HY-W013573	S-Allyl-L-cysteine	Inducer	98.64%	Unkown
HY-163690	HTRA1-IN-1	Inhibitor	95.28%	Unkown
HY-18740A	Trequinsin hydrochloride	Inhibitor	99.86%	Unkown
HY-N4170	Chebulic acid		99.89%	Unkown
HY-N6818	5,7,4'-Trimethoxyflavone		99.65%	Unkown
HY-W250160	PDRN		90.20%	Unkown
HY-43515	ESI1		99.76%	Unkown
HY-B1745A	Pyridoxylamine dihydrochloride		99.92%	Unkown
HY-101528	IDRA 21	Modulator	99.39%	Unkown
HY-164238	LysoPC(18:3)	Chemical	/	Unkown
HY-P10409	SHLP2		99.09%	Unkown
HY-W016414	Triethyl phosphate		99.95%	Unkown
HY-N0723	Neomangiferin		99.80%	Unkown
HY-N7690	3,5,7,3′,4′-Pentamethoxyflavone	Inhibitor	99.69%	Unkown
HY-137817	BCH001	Inhibitor	98.72%	Unkown
HY-106353	Smilagenin	Agonist	98.0%	Yes
HY-76383	LR-90	Inhibitor	99.24%	Unkown
HY-N4089	Quercetin 3-gentiobioside	Inhibitor	99.56%	Unkown
HY-P5904	Caveolin-1 (82-101) amide (human, mouse, rat)	Inhibitor	99.08%	Unkown
HY-W019724	2,2-Dihydroxyacetic acid	Activator	98.0%	Unkown
HY-W128156	10-Hydroxystearic acid	Agonist	99.94%	Unkown
HY-114988	PGE-M		99.9%	Unkown
HY-12462	WS3		98.70%	Unkown
HY-W020086	2,3-Diaminophenazine		99.84%	Unkown
HY-113303	FAPy-adenine		99.86%	Unkown
HY-128463	N-tert-Butyl-α-phenylnitrone	Inhibitor	99.94%	Unkown
HY-13101	MCOPPB trihydrochloride		99.98%	Unkown
HY-145628	CM398	Ligand	99.85%	Unkown
HY-N1517	Ganoderic acid C2		99.72%	Unkown
HY-N6588	3,4,5-Tricaffeoylquinic acid	Inhibitor	98.71%	Unkown
HY-137967	Genistein 7-β-D-Glucuronide		98.76%	Unkown
HY-66015	Palmitoyl hexapeptide-12		99.17%	Unkown
HY-108036A	(S)-Pro-xylane		99.72%	Unkown
HY-128387	2,3-Butanediol		99.96%	Unkown
HY-129566	Withanolide B		≥99.0%	Unkown
HY-16561S	Resveratrol-d4		99.9%	Unkown
HY-A0299	H-Gly-Pro-Hyp-OH	Inhibitor	99.48%	Unkown
HY-B1169	Timonacic		≥98.0%	Unkown
HY-B1340	Carbadox	Inhibitor	98.0%	Unkown
HY-N3127	Orobol	Inhibitor	99.74%	Unkown
HY-N9914R	D-Psicose (Standard)	Inhibitor	99.89%	Unkown
HY-P0064	Palmitoyl Tetrapeptide-3	Inhibitor	99.18%	Unkown
HY-14892A	Gemigliptin tartrate	Inhibitor	99.52%	Unkown
HY-123936	SR12343	Inhibitor	99.66%	Unkown
HY-136093	Lixumistat hydrochloride		99.25%	Unkown
HY-N0859	Schisanhenol	Inhibitor	99.99%	Unkown
HY-N2217	Rotundic acid		99.41%	Unkown
HY-N2278	Kushenol A	Inhibitor	99.98%	Unkown
HY-B1953	Thiacloprid	Agonist	99.66%	Unkown
HY-DY1073	MitoPerOx (solution)		/	Unkown
HY-134633	Alpha-lipoic acid choline ester chloride		99.72%	Unkown
HY-I0626S2	Cytosine-d2		99.69%	Unkown
HY-154847	WM-662	Inhibitor	99.48%	Unkown
HY-15289	Ciproxifan maleate	Antagonist	99.68%	Unkown
HY-169266	BRD-K56819078	Inhibitor	99.93%	Unkown
HY-N0363	(+)-Columbianetin		99.04%	Unkown
HY-N0757	8-O-Acetylharpagide		99.75%	Unkown
HY-N2485	4'-Methoxyresveratrol		99.48%	Unkown
HY-N2550A	(+)-Coclaurine hydrochloride	Control	99.09%	Unkown
HY-W001288	Indole-4-carboxaldehyde	Activator	99.85%	Unkown
HY-W015616	Benzylacetone	Inhibitor	99.98%	Unkown
HY-W585874	Nε-(Carboxyethyl)lysine	Modulator	99.97%	Unkown
HY-117924	AUTEN-67	Inducer	97.14%	Unkown
HY-110291	A-971432	Agonist	99.31%	Unkown
HY-130221	(25S)-Δ7-Dafachronic acid		96.92%	Unkown
HY-170794	ALT-007	Inhibitor	99.81%	Unkown
HY-N3026	Soyasaponin Ab		99.20%	Unkown
HY-P2096	Hexapeptide-11		99.77%	Unkown
HY-P5220A	Acetyl hexapeptide-1 acetate		99.47%	Unkown
HY-14567	Ciproxifan	Antagonist	99.26%	Unkown
HY-N0857	Deoxyandrographolide	Activator	98.0%	Unkown
HY-N7426	3-Deoxyglucosone		95.0%	Unkown
HY-P1930A	Risuteganib hydrochloride	Inhibitor	98.64%	Yes
HY-14892B	Gemigliptin tartrate hydrate	Inhibitor	99.83%	Unkown
HY-179041	SZ0232		99.25%	Unkown
HY-B0265A	(R)-Nimodipine	Antagonist	99.87%	Unkown
HY-N0363A	(+)-Columbianetin acetate		99.83%	Unkown
HY-NP162	Recombinant Humanized Type XVII Collagen		95.00%	Unkown
HY-P2914	Carnitine acetyltransferase		/	Unkown
HY-P2940	NADase		/	Unkown
HY-P3163	Hexapeptide-9		99.28%	Unkown
HY-P5251	Oligopeptide-68		98.56%	Unkown
HY-130687A	Psicose		99.90%	Unkown
HY-N2026S1	Propylparaben-d4		99.55%	Unkown
HY-W013494S	L-Carnosine-d4		99.84%	Unkown
HY-W747597	Ganglioside GD1b Disodium Salt (Bovine Brain)		98%	Unkown
HY-136093B	Lixumistat		99.33%	Unkown
HY-16467	Squalamine lactate	Inhibitor	98.42%	Unkown
HY-108036	Pro-xylane (30% in water)		98.0%	Unkown
HY-108036B	Pro-xylane		98.0%	Unkown
HY-125931	Unifiram	Activator	99.68%	Unkown
HY-128387S1	2,3-Butanediol-d8		99.28%	Unkown
HY-129380A	Fructosyl-lysine dihydrochloride		95.0%	Unkown
HY-139464	Q134R		99.11%	Unkown
HY-162866	CXM102	Activator	99.36%	Unkown
HY-162904	BPU17		98.16%	Unkown
HY-169265	BRD-K20733377	Inhibitor	99.50%	Unkown
HY-N2947	Boeravinone B	Inhibitor	97.59%	Unkown
HY-N7628	Cassiaside C		99.90%	Unkown
HY-P0099	Pentapeptide-3	Antagonist	99.83%	Unkown
HY-W012382S	N-Acetyl-L-tyrosine-d3		98.44%	Unkown
HY-Y0785	Glyoxal (40% w/w in water)		/	Unkown
HY-P5220	Acetyl hexapeptide-1		99.43%	Unkown
HY-W442049	Hydroxypinacolone retinoate		99.33%	Unkown
HY-11053	S 24795	Agonist	99.66%	Unkown
HY-114653	SRPIN803	Inhibitor	99.70%	Unkown
HY-126487A	H-Arg-Lys-OH TFA		99.86%	Unkown
HY-136688	MI-389	Inhibitor	99.34%	Unkown
HY-155988	Sirtuin modulator 6	Modulator	99.70%	Unkown
HY-173463	Sirtuin modulator 8	Modulator	96.24%	Unkown
HY-178239A	DX-8951 Hydroxy-acid sodium		98.65%	Unkown
HY-P0095	Acetyl tetrapeptide-5	Inhibitor	99.42%	Unkown
HY-P2663	Acetyl tetrapeptide-2		99.70%	Unkown
HY-N13212	Wolfberry Extract		/	Unkown
HY-W089800	trans-2-Nonenal		98.99%	Unkown
HY-107652	AF-DX 384	Antagonist	98.0%	Unkown
HY-124609	CAD031		99.39%	Unkown
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-147108	Mitochondria degrader-1	Inducer	95.10%	Unkown
HY-15492	AG-13958	Inhibitor	99.69%	Unkown
HY-164826	Acetyl zingerone		99.34%	Unkown
HY-186178	CD38-IN-6	Inhibitor	99.96%	Unkown
HY-65008	N-Demethylricinine		99.94%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.78%	Unkown
HY-N3757	(+)-Dihydrorobinetin		98.0%	Unkown
HY-P0104	Palmitoyl tripeptide-38	Activator	99.83%	Unkown
HY-156781	Sirtuin-1 inhibitor 1	Inhibitor	98.09%	Unkown
HY-161088	Anti-aging agent 1	Inhibitor	98.75%	Unkown
HY-164066	Sodium Acetylated Hyaluronate		/	Unkown
HY-17657	Androst-5-enediol sulfate sodium		99.90%	Unkown
HY-113127	L-Tryptophanamide		98.04%	Unkown
HY-133859	M084	Inhibitor	/	Unkown
HY-137557A	(E/Z)-Florzolotau	Ligand	98.01%	Unkown
HY-145486	1-Arachidonoyl-sn-glycerol 3-phosphate ammonium		/	Unkown
HY-153917	CRT0063465	Ligand	99.64%	Unkown
HY-156023	SIRT1 activator 2	Activator	99.28%	Unkown
HY-168336	E0924G	Activator	99.17%	Unkown
HY-169204	Mito-fisetin mF3	Inhibitor	/	Unkown
HY-172285	Cy3 hydrazide		/	Unkown
HY-172285A	Cy3 hydrazide bromide		/	Unkown
HY-178239	DX-8951 Hydroxy-acid		/	Unkown
HY-I0626S1	Cytosine-13C,15N2		98%	Unkown
HY-N12486A	(3S,8R,9R)-Isofalcarintriol		/	Unkown
HY-N8375	Sieboldin	Inhibitor	98.80%	Unkown
HY-N9347	Stepharine	Inhibitor	98.0%	Unkown
HY-P5237	Tetrapeptide-4	Activator	99.54%	Unkown
HY-P5250	Palmitoyl tripeptide-5	Inhibitor	/	Unkown
HY-Q49697	Sirtuin modulator 3	Modulator	99.32%	Unkown
HY-W614656	Pterostilbene glucoside		99.80%	Unkown
HY-116711	11-cis-Retinal		65.0%	Unkown
HY-12688	Succinyl phosphonate	Inhibitor	/	Unkown
HY-181604	MDH2-IN-2	Inhibitor	/	Unkown
HY-19878	Seletinoid G	Agonist	90.86%	Unkown
HY-N1190	DL-Syringaresinol	Inhibitor	96%	Unkown
HY-N2026A	Propylparaben sodium		99.03%	Unkown
HY-N2026R	Propylparaben (Standard)		99.81%	Unkown
HY-RS17216	Ager Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W268155	3,4'-Dihydroxypropiophenone		95.35%	Unkown
HY-184142	EYE1118	Inhibitor	/	Unkown
HY-N6818R	5,7,4'-Trimethoxyflavone (Standard)		/	Unkown
HY-135435	SU10944	Inhibitor	/	Unkown
HY-10104	GRL-8234	Inhibitor	/	Unkown
HY-107317	7-Keto-Naturalean		/	Unkown
HY-107811A	Harmol hydrochloride		/	Unkown
HY-107965	Safflower oil (from Carthamus tinctorius seed)	Inhibitor	/	Unkown
HY-113033A	Pentosidine TFA		/	Unkown
HY-119125	BMS-317180	Agonist	/	Unkown
HY-123681	R 57720		/	Unkown
HY-124223	AF-DX 384 methanesulfonate	Antagonist	/	Unkown
HY-128135	MHY 553	Agonist	/	Unkown
HY-128387S	2,3-Butanediol-d6		/	Unkown
HY-128463S	N-tert-Butyl-α-phenylnitrone-d14		/	Unkown
HY-131528	Tenilsetam		99.79%	Unkown
HY-133804	Arteanoflavone	Inhibitor	/	Unkown
HY-133806	Fumarranol	Inhibitor	/	Unkown
HY-133968S1	24-Methylenecholesterol-13C		/	Unkown
HY-138830A	(S,S)-TAK-418	Inhibitor	/	Unkown
HY-142778	Lp-PLA2-IN-10		/	Unkown
HY-145545	1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE		/	Unkown
HY-14567A	Ciproxifan hydrochloride	Antagonist	/	Unkown
HY-148322	Sirtuin modulator 5	Modulator	/	Unkown
HY-14892C	Gemigliptin hydrochloride	Inhibitor	/	Unkown
HY-151487	CypD-IN-3	Inhibitor	/	Unkown
HY-151488	CypD-IN-4	Inhibitor	/	Unkown
HY-151489	CypE-IN-1	Inhibitor	/	Unkown
HY-151546	MRS4596	Antagonist	/	Unkown
HY-151547	MRS4719	Antagonist	/	Unkown
HY-153183	Lp-PLA2-IN-12	Inhibitor	/	Unkown
HY-153560	Lp-PLA2-IN-14	Inhibitor	/	Unkown
HY-15492A	AG-13958 (mono(hydrochloride))	Inhibitor	/	Unkown
HY-155138	GLS1 Inhibitor-7	Inhibitor	/	Unkown
HY-156434	PDE11A4-IN-1	Inhibitor	/	Unkown
HY-159925	QKY-613	Activator	98.24%	Unkown
HY-162269	Nampt activator-5	Activator	/	Unkown
HY-162515	8-OAc		/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-163403	VEGFR-2-IN-43	Inhibitor	/	Unkown
HY-16561G	Resveratrol (GMP)		/	Unkown
HY-16561S1	Resveratrol-13C6		/	Unkown
HY-167711	Sirtuin modulator 9	Inducer	/	Unkown
HY-167740	Glycerophosphoinositol (lysine)		/	Unkown
HY-169846	CL5D		/	Unkown
HY-171336	TRC4186	Inhibitor	/	Unkown
HY-171925	BI-1124	Inhibitor	/	Unkown
HY-173337	HSP90α-IN-1	Inhibitor	/	Unkown
HY-174157	AR493	Activator	/	Unkown
HY-176127	JX10	Inhibitor	/	Unkown
HY-177945	MS99-β-Gal	Degrader	/	Unkown
HY-178284	Factor B-IN-7	Inhibitor	/	Unkown
HY-179657	PROTAC p300 degrader-2	Inhibitor	/	Unkown
HY-181589	PDE11A4-IN-2	Inhibitor	/	Unkown
HY-182303	Carboxyatractyloside	Inhibitor	/	Unkown
HY-182385	BPN-14136	Inhibitor	/	Unkown
HY-183057	GRK2 modulator 1		/	Unkown
HY-183306	mTOR/STAT3-IN-1	Inhibitor	/	Unkown
HY-183572	BW813U	Inhibitor	/	Unkown
HY-184141	EYE1090	Inhibitor	/	Unkown
HY-184158	HATC	Degrader	/	Unkown
HY-18740	Trequinsin	Inhibitor	/	Unkown
HY-B0801AS	Fexofenadine-d10 hydrochloride	Inhibitor	/	Unkown
HY-B1340S	Carbadox-d3	Inhibitor	/	Unkown
HY-D2990	KSA01		/	Unkown
HY-D2992	KSA02		/	Unkown
HY-D3208	oLOX		/	Unkown
HY-E70022	D-Mannose isomerase (PsMaSeAF)		/	Unkown
HY-E70410	NAD Synthetase		/	Unkown
HY-I0626S	Cytosine-13C2,15N3		/	Unkown
HY-N0679S	Retinyl acetate-d3		/	Unkown
HY-N0757R	8-O-Acetylharpagide (Standard)		/	Unkown
HY-N0859R	Schisanhenol (Standard)	Inhibitor	/	Unkown
HY-N1097	Venoterpine		/	Unkown
HY-N12653	Exserohilone	Inhibitor	/	Unkown
HY-N13232	Grape Skin Extract		/	Unkown
HY-N13380	6′‐O‐Galloylsalidroside		/	Unkown
HY-N15152	Isoaesculioside D		/	Unkown
HY-N1517A	(Rac)-Ganoderic acid C2	Inhibitor	/	Unkown
HY-N15225	12β-Hydroxyganoderenic acid B		/	Unkown
HY-N17816	Tambulin		/	Unkown
HY-N17872	Tenuifoliose W		/	Unkown
HY-N18386	Altissimacoumarin F		/	Unkown
HY-N18644	Calendula extract		/	Unkown
HY-N18682	Lonicera caprifolium extract		/	Unkown
HY-N18701	Achillea millefolium extract		/	Unkown
HY-N19082	Triphala extract		/	Unkown
HY-N19836	iso-Pedilanthocoumarin B		/	Unkown
HY-N2026AR	Propylparaben sodium (Standard)		/	Unkown
HY-N2026S	Propylparaben-d7		/	Unkown
HY-N20622	Terrestric acid		/	Unkown
HY-N2217R	Rotundic acid (Standard)		/	Unkown
HY-N2550	(+)-Coclaurine		/	Unkown
HY-N3612	Communic acid	Inhibitor	/	Unkown
HY-N6883	6-Methoxytricin	Inhibitor	/	Unkown
HY-NP002I	Sheep Serum Albumin		/	Unkown
HY-P0033A	Argireline acetate	Inhibitor	/	Unkown
HY-P10140	JNK-IN-15, Cell-Permeable	Inhibitor	/	Unkown
HY-P10141	JNK-IN-15, Cell-Permeable, Negative Control	Inhibitor	/	Unkown
HY-P10611	[D-Ser14]-Humanin		/	Unkown
HY-P11164	PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA	Ligand	/	Unkown
HY-P11656	α-Neoendorphin (porcine)		/	Unkown
HY-P1614	ZEP-3	Inhibitor	/	Unkown
HY-P2830	Complement factor D		/	Unkown
HY-P4308	Z-Pro-Pro-aldehyde-dimethyl acetal	Inhibitor	/	Unkown
HY-P5233	Acetyltetrapeptide 11	Inhibitor	/	Unkown
HY-RS00444	AGER Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W001083S1	3-Hydroxyphenylacetic acid-d5		/	Unkown
HY-W001083S2	3-Hydroxyphenylacetic acid-d6		/	Unkown
HY-W002968	SAHH-IN-1	Inhibitor	/	Unkown
HY-W127725	Thymolphthalexon tetrasodium		/	Unkown
HY-W127738	6-O-Stearoyl-L-ascorbic acid		/	Unkown
HY-W392413	Glutathione monoethyl ester	Inhibitor	/	Unkown
HY-W997836A	4-Amino-3-hydroxyphenylalanine dihydrochloride		98.97%	Unkown
HY-10380	(R)-DRF053	Inhibitor	/	Unkown
HY-107758	Y-29794 oxalate	Inhibitor	/	Unkown
HY-113033	Pentosidine		/	Unkown
HY-123754	AGN-201904	Inhibitor	/	Unkown
HY-123904	UoS12258	Activator	99.86%	Unkown
HY-138576	IDO1-IN-26	Inhibitor	98.22%	Unkown
HY-142025	Daumone		/	Unkown
HY-150179	ALCAT1-IN-1	Inhibitor	/	Unkown
HY-150361	Mouse Tert mRNA		/	Unkown
HY-154951	Oct4 inducer-2	Inducer	/	Unkown
HY-163103	(S)-Isomyosmine		/	Unkown
HY-165339	Lysyl-phenylalanyl-lysine	Inhibitor	/	Unkown
HY-167632	meso-Zeaxanthin		93.09%	Unkown
HY-168957	RuDiOBn	Inhibitor	/	Unkown
HY-169085	LRAT-IN-1	Inhibitor	/	Unkown
HY-174438	PSEC13	Modulator	/	Unkown
HY-175349	Tyrosinase-IN-43	Inhibitor	/	Unkown
HY-175862	ALR2-IN-9		/	Unkown
HY-185128	PE(P-16:0/18:2(9Z,12Z))		/	Unkown
HY-B1953S	Thiacloprid-d4	Agonist	/	Unkown
HY-N0363AR	(+)-Columbianetin acetate (Standard)		/	Unkown
HY-N0363R	(+)-Columbianetin (Standard)		/	Unkown
HY-N12071	Lucidin-ω-Me ether		/	Unkown
HY-N12486	Isofalcarintriol		/	Unkown
HY-N13261	Brickellin		/	Unkown
HY-N13299	Glucoberteroin		/	Unkown
HY-N8380	(-)-Latifolin		/	Unkown
HY-P3164	Acetyl tetrapeptide-9		/	Unkown
HY-RS23668	Ager Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W001288S	Indole-4-carboxaldehyde-13C	Activator	/	Unkown
HY-W050154S	Kojic acid-13C6	Inhibitor	/	Unkown
HY-W722107	Timonacic-d4		/	Unkown
HY-W997836	4-Amino-3-hydroxyphenylalanine		/	Unkown
HY-Y0785S	Glyoxal-d2		/	Unkown
HY-P3252AS	Pegcetacoplan-13C3,15N TFA		/	Unkown

Inhibitory Antibodies (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9951A	Ranibizumab (anti-VEGF)	Inhibitor	99.60%	Unkown
HY-P991488	BI-765423	Inhibitor	95.52%	Unkown
HY-P990859	Anti-CD44 Antibody (Hermes-1)		≥95.0%	Unkown
HY-P991886	ANX-M1 (Human IgG1)	Inhibitor	99.0%	Unkown
HY-P990328	Anti-AGER/RAGE Antibody (XT-M4)	Inhibitor	≥99.0%	Unkown
HY-P99402	Rinucumab	Inhibitor	99.9%	Unkown
HY-P99905	Efdamrofusp alfa		99.89%	Unkown
HY-P992151	Sphingomab	Inhibitor	/	Unkown
HY-P992142	Vonaprument	Inhibitor	/	Unkown
HY-P991385	UBX2050	Inhibitor	/	Unkown
HY-P991534	PF-04382923	Inhibitor	/	Unkown
HY-P992465	SIWA318H		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ager	NCBI	NCBI:177