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Neuro-Skeletal Interaction Mechanisms and Targeted Interventions

Intercellular Communication & Diseases Chronic Inflammation Calcium Homeostasis Metabolic Diseases

Neuro-skeletal interactions comprise central, autonomic, and sensory pathways that regulate bone formation, resorption, repair, vascular coupling, and pain. Bone is innervated rather than mechanically autonomous, and skeletal signals can in turn alter neural activity through pain and metabolic feedback. A foundational mouse study showed that leptin acted through a hypothalamic-sympathetic route to inhibit bone formation independently of appetite control. Later work demonstrated that sensory innervation also contributes to bone-mass accrual. These discoveries created a neuro-skeletal framework in which neurotransmitters, neuropeptides, guidance cues, osteoblasts, osteoclasts, immune cells, and skeletal progenitors form a bidirectional regulatory system relevant to osteoporosis, fracture, osteoarthritis, and bone pain[1][2][3][4].

In leptin-deficient mice, reduced sympathetic tone accompanied high bone mass. Genetic or pharmacological loss of adrenergic signaling produced a leptin-resistant high-bone-mass phenotype, while β-adrenergic receptors on osteoblasts regulated proliferation; agonism reduced and antagonism increased bone mass in mouse models. Sensory regulation differs mechanistically. Neuron-derived semaphorin 3A maintained sensory innervation of trabecular bone, and neural Sema3A deletion or sensory ablation reduced bone mass without changing sympathetic fibers. Injury adds nerve growth factor and other neurotrophic signals that sensitize and remodel bone-innervating fibers, linking repair to pain. These pathways show that autonomic tone, axon guidance, neurotrophin signaling, and skeletal-cell activity can be targeted separately[1][2][3].

Intervention must distinguish structural biology from analgesia. In a randomized trial of 698 adults with hip or knee osteoarthritis inadequately controlled by standard analgesics, the anti-nerve-growth-factor antibody tanezumab modestly improved pain, physical function, and global assessment at 16 weeks. Rapidly progressive osteoarthritis occurred only in treated groups, and joint replacements were more frequent than with placebo. This result demonstrates both the therapeutic potential and structural risk of blocking a neural growth signal in diseased joints. Other preclinical directions include selective adrenergic modulation, Sema3A-guided reinnervation, neuropeptide delivery, neuromodulatory biomaterials, and coordinated nerve-vessel regeneration for fractures or implants[1][2][3][4].

Major gaps include species differences, anatomical heterogeneity, and opposing effects across disease stages. Sympathetic or sensory signals that support normal remodeling may worsen pain, while analgesia can change loading and mask joint deterioration. Future studies should map nerve subtype, transmitter, receptor-bearing skeletal cell, vascular niche, and immune context in human bone. Trials need imaging and structural endpoints alongside pain and function, with long follow-up for fracture, osteonecrosis, rapidly progressive disease, and joint replacement. Local delivery may reduce systemic cardiovascular, metabolic, or sensory effects, but must demonstrate controlled exposure and intact protective sensation. Precision interventions should modify one defined neural-skeletal circuit without broadly denervating bone or suppressing signals required for repair. Mechanistic intervention studies should include weight bearing, gait, vascular supply, mineralization, turnover, and innervation because improvement in one endpoint may conceal harm in another. Human bone biopsies and advanced imaging could test whether mouse-defined receptors occupy the same cells and niches. Rehabilitation and loading should be recorded as biological inputs, not background noise, because sensory feedback and mechanical adaptation are coupled. Biomaterials should be evaluated for nerve density, pain, bone quality, and long-term remodeling rather than callus volume alone[1][2][3][4].

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Cat. No. Product Name Information Application Publication
HY-13948B Angiotensin II human TFA
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
Angiotensin Receptor   Apoptosis  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
259
HY-13948A Angiotensin II human acetate
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
Angiotensin Receptor   Apoptosis  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Viral Infection   Digestive System Inflammation   Cardiovascular Disease  
259
HY-13948 Angiotensin II human
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
Angiotensin Receptor   Apoptosis  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Viral Infection   Digestive System Inflammation   Cardiovascular Disease  
259
HY-B0468 Isoprenaline hydrochloride
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.
Adrenergic Receptor  
Obesity  
97
HY-L018 TGF-beta/Smad Compound Library
The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc. MCE designs a unique collection of 458 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Signaling Pathway Targeting Libraries

83
HY-L034M Anti-Aging Compound Library Mini
Research has shown that drugs targeting aging pathways demonstrate promising potential in models of age-related diseases such as Alzheimer's disease, cardiovascular diseases, metabolic syndrome, osteoarthritis, and various malignancies. This suggests that intervening in the biological processes of aging may enable synergistic prevention and treatment of multiple chronic diseases. Against the backdrop of the gradual elucidation of core aging mechanisms-including cellular senescence, telomere attrition, epigenetic dysregulation, and chronic inflammation anti-aging research has shifted from traditional phenotypic interventions toward targeting key pathways that regulate biological age. The MCE Anti-Aging Compound Library Mini is precisely built upon this cutting-edge concept. It focuses on aging-related targets validated through genetic or functional studies, comprising 381 compounds designed to provide systematic research tools for aging biology and intervention strategy development. The library covers core mechanisms such as mTOR, SIRT, energy metabolism, clearance of senescent cells, optimization of mitochondrial function, and telomere maintenance. For each target, 1-5 compounds with clear activity and strong representativeness have been carefully selected, spanning the entire translational spectrum from preclinical tool molecules to clinically investigational drugs.

Disease Focused Libraries

83
HY-L038 Differentiation Inducing Compound Library
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method. MCE Differentiation Inducing Compound Library contains a unique collection of 2,574 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Signaling Pathway Targeting Libraries

83
HY-L079 Anti-Blood Cancer Compound Library
Blood cancers, also called hematologic cancers, occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection and produce new blood cells. Most blood cancers start in the bone marrow, which is where blood is produced. There are three main types of blood cancers: leukemia, lymphoma and myeloma, which afflict millions of children and adults every year, and are often deadly. Some common blood cancer treatments include stem cell transplantation, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. As we begin to understand the key signaling pathways and molecular drivers of malignant transformation in haematological disorders, new treatment strategies will continue to be developed. MCE offers a unique collection of 4,333 compounds with identified and potential anti-blood cancer activity. These compounds target blood cancer’s major targets and signaling pathways. MCE anti-blood cancer compound library is a useful tool for anti-blood cancer drugs screening and other related research.

Disease Focused Libraries

83
HY-L087 Anti-Obesity Compound Library
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 3,741 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Disease Focused Libraries

83
HY-L131 Osteogenesis Compound Library
Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health. Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Osteoblast formation and bone formation are regulated by hormones, growth factors, cytokines, etc. MCE offers a unique collection of 984 bone formation compounds with identified and potential inducing osteogenesis activity. MCE bone formation compound library is a useful tool for the study of bone disease drugs and pharmacology.

Signaling Pathway Targeting Libraries

83
HY-L171 Anti-Hematopathy Compound Library
Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs. MCE designs a unique collection of 4,388 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

Disease Focused Libraries

83
HY-L174 Macrophage Related Compound Library
Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 276 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L197 Vitamin Compound Library
Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases. MCE included 136 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.
83
HY-L210 Anti-Rheumatic Arthritis Compound Library
Rheumatoid Arthritis (RA) is a autoimmune disease characterized by persistent joint inflammation. The pathology of RA includes immune cell infiltration, synovial lining proliferation, pannus formation, and the destruction of joint cartilage and bone, which is highly disabling. Due to long-term chronic inflammation, RA not only severely affects the quality of life of patients but can also damage multiple organs, leading to lung diseases, cardiovascular diseases, and malignant tumors. The pathogenesis of RA is complex, involving genetic, environmental, and immune factors. With the advancement of high-throughput screening technology, screening for compounds targeting JAK, CCR, MEK, MMP targets may contribute to the development of more effective drugs against Rheumatoid Arthritis (RA). MCE has collected 2,023 small molecule compounds with definite or potential anti-rheumatoid arthritis activity. This library is of significant value for researching the anti-RA drugs.
83
HY-L249 Lactylation Compound Library
Protein lactylation, an emerging post-translational modification identified in recent years, plays a critical role in linking cellular metabolic reprogramming, epigenetic regulation, and signaling networks. Based on a systematic framework encompassing lactate metabolism, lactylation, and downstream signaling pathways, this compound library comprehensively targets multiple regulatory layers, including histone modification enzymes (such as p300 and HDACs), key glycolytic enzymes (such as PKM2, LDHA, and GAPDH), transcriptional regulators (such as STAT3, HMGB1, and p53), as well as central signaling pathway nodes including HIF-1α, NF-κB, and PI3K-AKT-mTOR. This integrated design enables a comprehensive representation of the regulatory roles of lactylation across the “metabolism–epigenetics–signaling” axis. MCE has assembled a collection of 6,182 known bioactive compounds and potential functional molecules, making this library suitable for a wide range of applications, including high-throughput drug screening, inhibitor identification, and mechanistic studies. It can be used to systematically evaluate the functional roles of lactylation in biological processes such as tumor metabolism, immune regulation, and inflammatory responses, and to efficiently identify small-molecule candidates with regulatory potential, thereby facilitating the development of innovative therapeutics targeting the interplay between metabolism and epigenetic regulation.

Signaling Pathway Targeting Libraries

83
HY-L925 Cysteine Protease Focused Library
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors. This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Focused and target libraries

83
HY-L926 Cysteine Protease Focused Covalent Library
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors. This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

Focused and target libraries

83
HY-13715A Norepinephrine hydrochloride
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.
Adrenergic Receptor   Autophagy   Endogenous Metabolite  
Cancer   Depression   Cardiovascular Disease   Glucose Metabolism   Obesity  
79
HY-13715 Norepinephrine
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.
Endogenous Metabolite   Adrenergic Receptor   Autophagy  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
79
HY-B0573 Propranolol hydrochloride
Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
Adrenergic Receptor   Bacterial  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Depression   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension  
52
HY-B0573B Propranolol
Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
Adrenergic Receptor   Bacterial  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Depression   Alzheimer's Disease   Psoriasis   Hypertension  
52
HY-13951 Zenidolol hydrochloride
Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
Adrenergic Receptor  
Metabolic or Endocrine Disease   Depression   Alzheimer's Disease   Hypertension  
50
HY-10095 Olcegepant
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.
CGRP Receptor  
Neurological, Eye or Ear Disease   SARS-CoV-2 Infection  
47
HY-12497 ANA-12
ANA-12 is a brain-penetrant, selective TrkB antagonist with IC50 values of 45.6 nM and 41.1 μM, and Kd values of 10 nM and 12 μM, for high- and low-affinity sites, respectively. ANA-12 specifically inhibits BDNF-induced TrkB receptor activation and its downstream signaling cascades by directly and non-competitively binding to the TrkB receptor, without affecting the functions of TrkA and TrkC. ANA-12 is used in research concerning neuropsychiatric disorders (such as depression and anxiety), acute and chronic pain, neuroimmune inflammation, and the mechanisms of learning and memory.
Trk Receptor   NOD-like Receptor (NLR)   AIM2   Caspase  
Depression   Anxiety or Fear-Related Disease   Pain   CNS Infection   Behavioral Addiction  
41
HY-B0769 Phenylephrine
(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.
Adrenergic Receptor  
Cancer   Viral Infection   Depression   Cardiovascular Disease   Obesity  
38
HY-12678 Entrectinib
Entrectinib (NMS-E628) is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice.
ROS Kinase   Trk Receptor   Anaplastic lymphoma kinase (ALK)   Autophagy  
Lung Cancer   Prostate Cancer   Pancreatic Cancer   Pain   SARS-CoV-2 Infection  
32
HY-116771A CL 316243
CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors.CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
Adrenergic Receptor  
Depression   Glucose Metabolism   Obesity  
28
HY-N6732 K-252a
K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

Source: Nocardiopsis sp.

Autophagy   Trk Receptor   PKC   PKA   CaMK  
Infection   Inflammation or Immune System Disease  
27
HY-B0617 S-Adenosyl-L-methionine
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.

Source: Escherichia coli

Endogenous Metabolite   Apoptosis  
Cancer   Digestive System Disease   Depression   Digestive System Inflammation  
23
HY-W013372 7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases.
Trk Receptor   Apoptosis  
Neurological, Eye or Ear Disease  
21
HY-17498 Atenolol
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.
Adrenergic Receptor  
Cancer   Metabolic or Endocrine Disease   Depression   Alzheimer's Disease   Hypertension  
21
HY-12866 Larotrectinib
Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
Trk Receptor   Apoptosis  
Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Pain   Digestive System Inflammation   SARS-CoV-2 Infection  
17
HY-N0378 D-Mannitol
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
Environmental Pollutants   PGC-1α   Apoptosis   Adrenergic Receptor   Endogenous Metabolite   PKA  
Digestive System Disease   Prostate Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Parkinson's Disease   Obesity  
15
HY-N0390S1 L-Glutamine-13C5
L-Glutamine-13C5 is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
13
HY-15498 Rimegepant
Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine .
CGRP Receptor  
Migraine  
12
HY-18314 GW 441756
GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth.
Trk Receptor   Apoptosis  
Cancer   Digestive System Disease   Pain   Digestive System Inflammation  
11
HY-18732A L-NMMA acetate
L-NMMA (Tilarginine) acetate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA acetate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA acetate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA acetate is applicable to research related to nociception, bone cancer pain, and myopia.
NO Synthase  
Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Obesity   Lung Fibrosis  
11
HY-B0527 Amitriptyline
Amitriptyline is an orally active tricyclic antidepressant (TCA). Amitriptyline mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline can reduce inflammation, angiogenesis and fibrosis. Amitriptyline binds to DAT (with Ki = 2.58 μM). Amitriptyline has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity.
Serotonin Transporter   5-HT Receptor   mAChR   Sodium Channel   Adrenergic Receptor   Trk Receptor   Histamine Receptor   Potassium Channel   Dopamine Transporter   Apoptosis  
Digestive System Disease   Depression   Pain   Digestive System Inflammation   SARS-CoV-2 Infection   Pseudomonas Aeruginosa Infection   Alzheimer's Disease   Parkinson's Disease   Hypertension   Obesity  
9
HY-P0209 Rat CGRP-(8-37)
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
CGRP Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
9
HY-103022 Repotrectinib
Repotrectinib (TPX-0005) is a potent ROS1 (IC50=0.07 nM) and TRK (IC50=0.83/0.05/0.1 nM for TRKA/B/C) inhibitor. Repotrectinib potently inhibits WT ALK (IC50=1.01 nM). Repotrectinib has anti-cancer activity.
ROS Kinase   Trk Receptor   Anaplastic lymphoma kinase (ALK)  
Pain   Non-Small Cell Lung Cancer  
9
HY-P0203 α-CGRP (mouse, rat)
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.
CGRP Receptor  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
9
HY-B2162A Chondroitin sulfate sodium (from shark cartilage)
Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
NO Synthase   MMP   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
8
HY-110066 (Z)-Guggulsterone
(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection.
Apoptosis   VEGFR   Akt   Angiotensin-converting Enzyme (ACE)   SARS-CoV   FXR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Pain   Digestive System Inflammation   Hypertension   Obesity   Lung Fibrosis  
8
HY-B2162 Chondroitin sulfate
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
NO Synthase   MMP   Endogenous Metabolite  
Inflammation or Immune System Disease   Pancreatic Cancer   Pain   Lung Fibrosis  
8
HY-N0036 Costunolide
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells.
Apoptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Digestive System Disease   Breast Cancer   Digestive System Inflammation   Glucose Metabolism  
7
HY-B1811 Vasopressin
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
7
HY-N0816 Polyphyllin VI
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer.
Apoptosis   Pyroptosis  
Digestive System Disease   Lung Cancer   Depression   Digestive System Inflammation  
6
HY-P1071 α-CGRP (human)
α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects.
CGRP Receptor  
Hypertension  
6
HY-N0866 20-Deoxyingenol
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).
Autophagy  
Inflammation or Immune System Disease  
5
HY-N0772 Isomangiferin
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
VEGFR   NOD-like Receptor (NLR)   NF-κB   Bacterial   AMPK   Acetyl-CoA Carboxylase   Apoptosis   Reactive Oxygen Species (ROS)   HSV   Drug Derivative  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Depression   Pain   Autoimmune Disease   Digestive System Inflammation   Glucose Metabolism   Obesity   Lung Fibrosis  
4
HY-N6779 Patulin
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.

Source: Penicillium and Aspergillus

Bacterial   Apoptosis   Autophagy   Antibiotic  
Digestive System Disease   Bacterial Infection   Digestive System Inflammation  
4
HY-N0390S9 L-Glutamine-15N-1
L-Glutamine-15N-1 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
4
HY-N0390S L-Glutamine-15N
L-Glutamine-15N is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
4
HY-P1471 Adrenomedullin (AM) (22-52), human
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.
CGRP Receptor  
Blood or Cardio-cerebrovascular Disease  
4
HY-P81217 Osteocalcin Antibody
Osteocalcin Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Osteocalcin.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

4
HY-P9958A Denosumab (anti-TNFSF11)
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies.

Species: Human

RANKL/RANK   Apoptosis   NF-κB  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Metastatic Breast Cancer  
3
HY-N0648 Monotropein
Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury.
Interleukin Related   Keap1-Nrf2   Heme Oxygenase (HO)   NF-κB   Apoptosis  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Autoimmune Disease   Digestive System Inflammation   Obesity   Lung Fibrosis  
3
HY-N2532 Diphyllin
Diphyllin is an orally active V-ATPase inhibitor (IC50=17 nM) and HIV-1 inhibitor (IC50=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC50=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption.
VSV   HIV   Proton Pump   Influenza Virus  
Cancer   Inflammation or Immune System Disease   Viral Infection  
3
HY-107854 N-Acetyl-5-hydroxytryptamine
N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
Endogenous Metabolite   Trk Receptor  
Depression  
3
HY-P9958 Denosumab
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies.

Species: Human

NF-κB   Caspase   Apoptosis   RANKL/RANK  
Metabolic or Endocrine Disease   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Metastatic Breast Cancer  
3
HY-P3462A Cagrilintide acetate
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.
CGRP Receptor  
Metabolic or Endocrine Disease  
3
HY-P0090 Calcitonin (salmon)
Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
CGRP Receptor  
Cancer  
3
HY-P3462 Cagrilintide
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.
CGRP Receptor  
Metabolic or Endocrine Disease  
3
HY-P990071 Fepixnebart
Fepixnebart (LY3016859) is a humanized monoclonal hIgG4 antibody, which binds and neutralizes only TGFα and epiregulin with high affinity. Fepixnebart can be used for the study of diabetic nephropathy and broad-spectrum chronic pain, including diabetic peripheral neuropathic pain (DPNP), signs and symptoms of osteoarthritis (OA), and chronic low back pain (CLBP).

Species: Human

EGFR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
2
HY-N1374 Magnolin
Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
ERK  
Inflammation or Immune System Disease   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Obesity   Lung Fibrosis  
2
HY-P99463 Batiraxcept
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((KD <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis.
TAM Receptor   PI3K   Akt   p38 MAPK  
Cancer  
2
HY-B0025 Voglibose
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

Source: Streptomyces hygroscopicies var. limonons.

Glycosidase  
Colorectal Cancer   Glucose Metabolism   SARS-CoV-2 Infection   Parkinson's Disease  
2
HY-P99221 Tanezumab
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia.

Species: Human

Trk Receptor  
Inflammation or Immune System Disease   Pain  
2
HY-P7880 Alkaline Phosphatase/ALPL Protein, Human (HEK293, His)
Alkaline Phosphatase/ALPL Protein, Human (HEK 293, His) is a cell-surface homodimeric phosphohydrolase that is richly expressed in the skeleton, liver, kidney and developing teeth.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3) Phosphatase Alkaline Phosphatase

2
HY-113308AS Taurolithocholic acid-d4 sodium
Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
1
HY-Y0332H Sodium dihydrogen phosphate dihydrate, for molecular biology
Sodium dihydrogen phosphate dihydrate (Sodium phosphate monobasic dihydrate), for molecular biology is a phosphate compound and nucleating agent. At a content of 1.2%, Sodium dihydrogen phosphate dihydrate, for molecular biology eliminates the supercooling degree of sodium acetate trihydrate to 0°C while maintaining or slightly enhancing its latent heat storage capacity. Sodium dihydrogen phosphate dihydrate, for molecular biology can serve as a starting material for the synthesis of degradable sodium phosphate glasses, which are applied in craniomaxillofacial bone repair. Sodium dihydrogen phosphate dihydrate, for molecular biology is widely used in research on craniomaxillofacial bone repair and related fields.
Biochemical Assay Reagents  
1
HY-113230 Galactosylhydroxylysine
Galactosylhydroxylysine is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine is released during bone resorption and has been shown to be elevated in metabolic bone loss.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-17490 Oxaceprol
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis.
Amino Acid Derivatives  
Inflammation or Immune System Disease  
1
HY-113230B Galactosylhydroxylysine hydrochloride
Galactosylhydroxylysine hydrochloride is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine hydrochloride is released during bone resorption and has been shown to be elevated in metabolic bone loss.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-N0390S5 L-Glutamine-1-13C
L-Glutamine-1-13C is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
1
HY-Z0478 (-)-Limonene
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture.
Bacterial   Antibiotic   CaMK  
Metabolic or Endocrine Disease   Bacterial Infection   Cardiovascular Disease   Parkinson's Disease  
1
HY-NP160 Recombinant Humanized Type I Collagen
Recombinant Humanized Type I Collagen is a recombinant humanized collagen protein with has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc.
Biochemical Assay Reagents  
1
HY-P99419 Acasunlimab
Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer.

Species: Human

PD-1/PD-L1  
Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
1
HY-101898 Indo-1 AM
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions.
Fluorescent Dye  
1
HY-P990001 Anti-Mouse IL-10 Antibody (JES5-2A5)
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for researches on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM).

Species: Mouse

Interleukin Related  
Cancer   Metabolic or Endocrine Disease   Neurodegenerative Disease   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
1
HY-W013407 α-Methyltyrosine methyl ester hydrochloride
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research.
Tyrosine Hydroxylase   Thyroid Hormone Receptor  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
1
HY-N0390S2 L-Glutamine-d5
L-Glutamine-d5 is the deuterium labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
1
HY-P99144A Anti-Mouse PD-1 Antibody (S-5001)
Anti-Mouse PD-1 Antibody (S-5001) is a selective inhibitor targeting PD-1, blocking the PD-1/PD-L1 immune checkpoint axis through competitive binding to PD-1. Anti-Mouse PD-1 Antibody (S-5001) works by reversing the tumor immunosuppressive microenvironment and reactivating the anti-tumor activity of cytotoxic T lymphocytes. It can be used in research on tumors such as melanoma and HPV-positive oropharyngeal squamous cell carcinoma. Anti-Mouse PD-1 Antibody (S-5001) is often combined with photothermal therapy, chemotherapy, etc., to enhance efficacy.

Species: Mouse

PD-1/PD-L1  
Cancer Immunology   Immunotherapy for Melanoma   Squamous Cell Carcinoma  
1
HY-N0390S8 L-Glutamine-15N2
L-Glutamine-15N2 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
1
HY-W015273A trans-3-Indoleacrylic acid
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis
Endogenous Metabolite   Ferroptosis  
Metabolic or Endocrine Disease   Colorectal Cancer  
1
HY-P9982 Romosozumab
Romosozumab is a humanized monoclonal anti-sclerostin antibody, it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis.

Species: Human

Others  
Cancer   Metabolic or Endocrine Disease  
1
HY-P700666 BSP2 Protein, Cynomolgus (HEK293, His)
The BSP2 protein has strong hydroxyapatite-binding ability and is a component of the mineralized matrix, shaping the structural framework of tissues. Its association implies a crucial role in cell-matrix interactions, affecting both physical and functional aspects. BSP2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BSP2 protein, expressed by HEK293 , with C-His labeled tag.

Species: Cynomolgus; Source: HEK293

1
HY-P81047 Collagen II Antibody
Collagen II Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen II.

Host: Rabbit; Reactivity: Human

Polyclonal Antibodies Primary Antibodies

1
HY-P81047A Collagen II Antibody(YA3550)
Collagen II Antibody(YA3550) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen II.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

1
HY-K0350 Mouse Neutrophil Negative Selection Kit

MCE Mouse Neutrophil Negative Selection Kit can isolate neutrophils from single-cell suspensions of mouse bone marrow or other tissue samples.

Cell Biology Cell Isolation

1
HY-K0607 Modified Safranin O–Fast Green Cartilage Staining Kit

MCE Modified Safranin O–Fast Green Cartilage Staining Kit through an optimized staining system, cartilage matrix and bone tissue in histological sections can be clearly distinguished. This method provides high staining contrast, good sensitivity, simple operation, and good reproducibility, and is widely used for cartilage morphology observation, studies of cartilage injury and degeneration, osteochondral tissue development research, and related histological analyses.

Cell Biology Cell Analysis Staining Kit

1
HY-B0634S Aceclofenac-d4
Aceclofenac-d4 is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
Isotope-Labeled Compounds   COX  
Inflammation or Immune System Disease  
/
HY-18719S Endoxifen-d5 (Z-isomer)
Endoxifen-d5 (Z-isomer) is the deuterated-labeled Endoxifen (Z-isomer methanesulfonate) (HY-18719H). Endoxifen-d5 Z-isomer is an orally active selective PKCβ1 inhibitor with an IC50 of 360 nM against human PKCβ1. It also acts as an estrogen receptor modulator and antiestrogen. Endoxifen-d5 Z-isomer binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen-d5 Z-isomer inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. It can be used in research related to ER+ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors
PKC   Estrogen Receptor/ERR   PI3K   Akt   mTOR   Apoptosis   Reactive Oxygen Species (ROS)  
Breast Cancer   Melanoma   Glioblastoma  
/
HY-13738S Raloxifene-d4
Raloxifene-d4 is the deuterium labeled Raloxifene. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research.
Isotope-Labeled Compounds   Estrogen Receptor/ERR  
/
HY-P3637 AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG
AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG promotes bone-ossification. AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG can be used in the research of diseases or disorders related to osteogenic defects or bone mineral density (BMD) decreasing, such as osteoporosis.
Others  
Inflammation or Immune System Disease  
/
HY-N0684S1 Vitamin K1-d4
Vitamin K1-d4 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990248 Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) is an anti-mouse E-Cadherin/CD324 IgG1 monoclonal antibody. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can downregulate the HER signaling axis and PI3K/Akt/mTOR signaling pathway. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can inhibit the proliferation of tumor cells and induce their apoptosis. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can be used for researches on cancer and inflammation conditions such as breast cancer, chronic compression injury (CCI) and asthma.

Species: Mouse

Cadherin   EGFR   PERK   Akt   mTOR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Breast Cancer  
/
HY-17490S Oxaceprol-d3
Oxaceprol-d3 (N-Acetyl-L-hydroxyproline-d3) is deuterium labeled Oxaceprol. Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis.
Isotope-Labeled Compounds   Amino Acid Derivatives  
Inflammation or Immune System Disease  
/
HY-P991362 GB-223
GB-223 is a human monoclonal antibody (mAb) targeting TNFSF11/RANKL/CD254. GB-223 can be used in Giant cell tumour of bone and Postmenopausal osteoporosis research.

Species: Human

TNF Receptor  
Cancer  
/
HY-116640 Amorphigenin
Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.
AP-1   Nuclear Factor of activated T Cells (NFAT)   AMPK   Autophagy  
/
HY-138794G XL177A (GMP)
XL177A GMP is XL177A (HY-138794) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections.
Deubiquitinase   SARS-CoV   Histone Demethylase  
/
HY-P3539 Exendin-4 (3-39)
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.
GCGR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-N20033 Symphytum officinale extract
Symphytum officinale extract is an extract of comfrey (Symphytum officinale) used in research on wound healing, anti-inflammation, and fracture treatment.
Others  
Inflammation or Immune System Disease  
/
HY-P991324 MEDI-7352
MEDI-7352 is a human bispecific antibody (bsAb) targeting NGF/bNGF & TNF. MEDI-7352 can be used in osteoarthritis (OA) pain research.

Species: Human

Trk Receptor   TNF Receptor  
Inflammation or Immune System Disease  
/
HY-124410S Mitoquinol-d15
Mitoquinol-d15 is deuterium labeled Mitoquinol (HY-124410). Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs.
Isotope-Labeled Compounds   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W740983S Dexamethasone dipropionate-d5
Dexamethasone dipropionate-d5 is the deuterium labeled Dexamethasone dipropionate. Dexamethasone dipropionate is a Dexamethasone (HY-14648) ester. Dexamethasone dipropionate can be used in the research of osteoarthritis.
Isotope-Labeled Compounds   Drug Derivative  
Inflammation or Immune System Disease  
/
HY-P992336 CRB0017
CRB0017 is a recombinant monoclonal antibody targeting ADAMTS5, with high affinity for the spacer domain of ADAMTS5 and strong antigen specificity. CRB0017 binds to the spacer domain of ADAMTS5 and reduces the proteolytic activity of this enzyme. CRB0017 delays articular cartilage degradation, alleviates the pathological severity of osteoarthritis, and decreases the osteoarthritis histopathological score. CRB0017 is applicable to the research of osteoarthritis.

Species: Human

ADAMTS  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-N20407 Oyster extract
Oyster extract is an oyster extract that can be used for bone formation.
Others  
/
HY-N20370 Lactuca sativa extract
Lactuca sativa extract (Lactucascariola extract) is a type of lettuce (Lactuca Sativa) seed used to relieve inflammation and bone pain.
Others  
/
HY-12278G K02288 (GMP)
K02288 (GMP) is K02288 (HY-12278) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
TGF-β Receptor  
Cancer  
/
HY-D2132 Sulfo-Cy5.5-ALN
Sulfo-Cy5.5-ALN is a fluorescent labeled alendronate, which targets bone. Sulfo-Cy5.5-ALN binds to hydroxyapatite and differentiated osteoblasts in vitro. Sulfo-Cy5.5-ALN selectively binds to the mineralized areas of the tumor. Sulfo-Cy5.5-ALN can be used to detect bone overgrowth in prostate bone metastasis.
Fluorescent Dye  
Cancer  
/
HY-N0390G L-Glutamine (GMP)
L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
mTOR   NF-κB   STAT   HIF/HIF Prolyl-Hydroxylase  
Inflammation or Immune System Disease   Ischemic Stroke   Osteoporosis   Osteoarthritis  
/
HY-P3735 Bone Gla Protein (45-49)
Bone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo.
Others  
/
HY-N19975 Bonesof cervuselaphus extract
Bonesof cervuselaphus extract, derived from red deer bones, has a dual effect of promoting bone formation and inhibiting bone resorption.
Others  
Osteogenic Differentiation  
/
HY-P4835 pTH (2-34) (human)
pTH (2-34) (human) (80 μg/kg) slightly increases serum osteocalcin levels and alkaline phosphatase activity of bone extract (markers of bone formation) in mice. pTH (2-34) is not as effective as pTH (1-34).
Phosphatase  
/
HY-D1701 Mag-Fura-2 AM
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions.
Fluorescent Dye  
/
HY-P992377 HY-0102
HY-0102 is a humanized IgG anti-NKG2A monoclonal antibody and immune checkpoint inhibitor targeting the NKG2A/HLA-E axis. HY-0102 is applicable for the research of advanced solid tumors.

Species: Human

C-type Lectin-like Receptors (CTLRs)  
Cancer  
/
HY-P11800 GPLGVRG
GPLGVRG is an MMP13-responsive linker peptide. GPLGVRG can be hydrolyzed by MMP13, which in turn triggers micellar disintegration, loss of amphipathicity, and increases the chondrocyte uptake rate of the related delivery system. GPLGVRG can be used in the research of osteoarthritis.
MMP  
/
HY-P2414 MMP-13 Substrate
MMP-13 Substrate is a substrate of MMP-13. MMP-13 Substrate can be used for the research of osteoarthritis (OA).
MMP  
Inflammation or Immune System Disease  
/
HY-B2162H Chondroitin sulfate (from fish)
Chondroitin sulfate (from fish), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate (from fish) reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
NO Synthase   Endogenous Metabolite   MMP  
Inflammation or Immune System Disease  
/
HY-N0059S1 D-Arabinose-13C-1
D-Arabinose-13C-1 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).
Isotope-Labeled Compounds   Parasite   Bacterial   AMPK   PPAR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P992366 HFB200901
HFB200901 is a galectin LGALS9 inhibitor and immunostimulant that can be used in studies related to pancreatic adenocarcinoma, pancreatic intraepithelial neoplasia, KRASG12C-mutant colon cancer, and prostate cancer. HFB200901 disrupts the LGALS9/TIM-3 axis, while blocking the internalization and vacuolization of recombinant LGALS9. HFB200901 reduces the proportion of regulatory T cells (Treg) and enhances dendritic cell activation, thereby inducing polyfunctional and memory CD8+ T cell responses. HFB200901 inhibits the progression of pancreatic neoplastic lesions and effectively improves the efficacy of PSMA-based vaccination.

Species: Human

Galectin   Tim3  
Prostate Cancer  
/
HY-113308AS2 Taurolithocholic acid-d4-1 sodium
Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
/
HY-P992312 APX008
APX008 is a monoclonal antibody that targets RANKL and is a RANKL inhibitor. APX008 can be used in research on bone diseases.

Species: Human

NF-κB  
Musculoskeletal and Skin Disease  
/
HY-P2414A MMP-13 Substrate TFA
MMP-13 Substrate TFA is a substrate of MMP-13. MMP-13 Substrate TFA can be used for the research of osteoarthritis (OA).
MMP  
Inflammation or Immune System Disease  
/
HY-113308S Taurolithocholic acid-d5
Taurolithocholic acid-d5 is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
/
HY-17361S Etofenamate-d4
Etofenamate-d4 is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases.
Isotope-Labeled Compounds   COX  
Inflammation or Immune System Disease  
/
HY-N20096 Black bone rattan extract
Black bone rattan extract (Black bone vine extract) is an extract of the black bone vine (Gardneria angustifolia) that can be used in rheumatology research.
Others  
/
HY-P5377 Abz-HPGGPQ-EDDnp
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
Ser/Thr Protease  
/
HY-N16118 Asperosaponin V
Asperosaponin V is an indirect modulator of bone metabolism-related targets (e.g., PI3K/AKT, BMP-2/p38, and ERK 1/2 pathways). Asperosaponin V promotes marrow stromal cell proliferation and induces osteoblast differentiation. Asperosaponin V is promising for research of osteoporosis and fracture healing.
PI3K   Akt   p38 MAPK   ERK  
Metabolic or Endocrine Disease  
/
HY-N15719 Dipsacus saponin R
Dipsacus saponin R (Compound 1) is an orally active triterpenoid saponin found in Radix Dipsaci. Dipsacus saponin R promotes bone formation and repair by regulating osteoblast activity or inhibiting osteoclast function. Dipsacus saponin R is promising for research of bone diseases such as osteoporosis and fracture healing.
Others  
/
HY-107413G SR11237 (GMP)
SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease.
RAR/RXR   Tyrosine Hydroxylase  
Inflammation or Immune System Disease   Parkinson's Disease   Osteoarthritis  
/
HY-N12648 Anemarsaponin E1
Anemarsaponin E1 can be isolated from Guizhi-Shaoyao-Zhimu decoction (GSZD), and can be used for research of rheumatoid arthritis (RA), gout, osteoarthritis, etc.
Others  
Inflammation or Immune System Disease  
/
HY-NP195 Osteocalcin protein (Cow)
Osteocalcin protein (Cow) is the most abundant non-collagenous protein in bone and plays an important role in bone metabolism.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P991569 PF-04840082
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research.

Species: Human

Wnt  
Metabolic or Endocrine Disease  
/
HY-15893G DMOG (GMP)
DMOG (GMP) is the GMP level of DMOG (HY-15893). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DMOG (GMP) is a HIF-1α stabilizer. DMOG (GMP) promotes the osteogenic, angiogenic, and chondrogenic differentiation of stem cells by stabilizing the expression of HIF-1α. DMOG (GMP) can enhance the osteogenic and angiogenic differentiation potential of stem cells, thereby improving bone regeneration in bone defects. DMOG (GMP) can be used in the research of bone defect repair, vascularized bone regeneration, and the treatment of bone-related diseases (such as osteoporosis and femoral head necrosis) .
Autophagy   HIF/HIF Prolyl-Hydroxylase  
Blood or Cardio-cerebrovascular Disease  
/
HY-W088413A DOTA-amide dihydrate
DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs). DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer.
Biochemical Assay Reagents  
Cancer  
/
HY-N6779S Patulin-13C7
Patulin-13C7 (Terinin-13C7) is the 13C labeled Patulin (HY-N6779). Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.
Isotope-Labeled Compounds  
Infection  
/
HY-P4839 GLP-2 (1-34) (human)
GLP-2 (1-34) (human) is a polypeptide released from the intestine within minutes after food intake. GLP-2 (1-34) (human) can be used for the research of bone remodeling processes.
Others  
Metabolic or Endocrine Disease  
/
HY-P10287 Neuropeptide W-30 (human)
Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human) activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-P11207 NLS-CPP
NLS-CPP is a nuclear localization signal (NLS)-cell-penetrating peptide, which contains the NLS of OCT6. NLS-CPP facilitates nuclear delivery. NLS-CPP can be used for chronic inflammatory diseases s research, such as metabolic-dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA).
Others  
Inflammation or Immune System Disease  
/
HY-P11208A mNLS-CPP-scramble
mNLS-CPP-scramble is a negative control peptide of mNLS-CPP-WSTF. mNLS-CPP-scramble is promising for research of chronic inflammatory diseases (e.g., MASH, osteoarthritis).
GABA Receptor  
Inflammation or Immune System Disease  
/
HY-P10289 Neuropeptide W-30 (rat)
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-P11641 GCRRGPLGLSLGKRRCG
GCRRGPLGLSLGKRRCG is an MMP13-specific substrate peptide cleaved by MMP13. GCRRGPLGLSLGKRRCG contributes to an MMP13-responsive hydrogel microsphere system that achieves intelligent and controllable drug release in osteoarthritis (OA), decelerates disease progression, and promotes articular cartilage repair. GCRRGPLGLSLGKRRCG can be used for the research of osteoarthritis.
MMP  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P11669 Ventegatide
Ventegatide is an integrin-binding peptide that can be used for the study of osteoarthritis.
Integrin  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P0284 C-telopeptide
C-telopeptide is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD). C-telopeptide can be used in studies related to postmenopausal osteoporosis.
MMP  
Osteoporosis  
/
HY-N0648R Monotropein (Standard)
Monotropein (Standard) is the analytical standard of Monotropein. This product is intended for research and analytical applications. Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury.
Reference Standards   Interleukin Related   Heme Oxygenase (HO)   Keap1-Nrf2   NF-κB   Apoptosis  
Inflammation or Immune System Disease  
/
HY-W738852 Hydroxylysylpyridinoline-d6
Hydroxylysylpyridinoline-d6 is deuterium labeled Pyridinoline. Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-179551S (±)11(12)-EET-d11 Methyl ester
(±)11(12)-EET-d11 Methyl ester is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis.
Isotope-Labeled Compounds  
/
HY-18732AR L-NMMA acetate (Standard)
L-NMMA (Tilarginine) acetate (Standard) is the analytical standard of L-NMMA acetate (HY-18732A). This product is intended for research and analytical applications. L-NMMA (Tilarginine) acetate is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA acetate inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA acetate alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA acetate is applicable to research related to nociception, bone cancer pain, and myopia.
Reference Standards   NO Synthase  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-W749516 Voglibose-13C3
Voglibose-13C3 is the 13C-labeled Voglibose (HY-B0025). Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.
Isotope-Labeled Compounds   Glycosidase  
Metabolic or Endocrine Disease  
/
HY-N0772R Isomangiferin (Standard)
Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
Reference Standards   VEGFR   NF-κB   NOD-like Receptor (NLR)   AMPK   Acetyl-CoA Carboxylase   Apoptosis   Reactive Oxygen Species (ROS)   HSV   Drug Derivative  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B1811R Vasopressin (Standard)
Vasopressin (Standard) is the analytical standard of Vasopressin. This product is intended for research and analytical applications. Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
Endogenous Metabolite   Reference Standards  
Neurological, Eye or Ear Disease  
/
HY-32343S Secalciferol-d6
Secalciferol-d6 is the deuterium labeled Secalciferol. Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.
Isotope-Labeled Compounds   VD/VDR   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-17490R Oxaceprol (Standard)
Oxaceprol (Standard) is the analytical standard of Oxaceprol. This product is intended for research and analytical applications. Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis.
Amino Acid Derivatives   Reference Standards  
Inflammation or Immune System Disease  
/
HY-108685S Alendronate-d4 sodium
Alendronate-d4 (sodium) (Alendronic acid-d4 (monosodium salt)) is deuterium labeled Alendronate sodium. Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis.
Isotope-Labeled Compounds  
Cancer   Metabolic or Endocrine Disease  
/
HY-113308AS1 Taurolithocholic Acid-d5 sodium salt
Taurolithocholic Acid-d5 (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic Acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic Acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic Acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic Acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic Acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic Acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
/
HY-N0036R Costunolide (Standard)
Costunolide (Standard) is the analytical standard of Costunolide. This product is intended for research and analytical applications. Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells.
Reference Standards   Apoptosis   Endogenous Metabolite  
Breast Cancer  
/
HY-P2588A Osteocalcin (human) TFA
Osteocalcin (Osteocalcin (1-49)) (human) TFA is a vitamin K-dependent bone specific protein. Osteocalcin (human) TFA is chemotactic for several of the cell types frequently found at bone remodeling surfaces.
Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-N0390S7 L-Glutamine-15N2,d5
L-Glutamine-15N2,d5 is the deuterium and 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-Y1322S Triphenyl phosphate-d15
Triphenyl phosphate-d15 is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.
JNK   Apoptosis   Isotope-Labeled Compounds   Indoleamine 2,3-Dioxygenase (IDO)   Akt   Reactive Oxygen Species (ROS)   PPAR   ERK   NF-κB   Mitophagy   PI3K   Environmental Pollutants   p38 MAPK   Monoamine Oxidase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Urogenital Disease  
/
HY-N19066 Cissus quadrangularis extract
Cissus quadrangularis extract contains a variety of bioactive compounds, such as flavonoids, phenolic acids, carotenoids, triterpenoids, vitamins, 3-ketosteroids, minerals, and sterols. Cissus quadrangularis extract can promote fracture healing, reduce bone loss, and increase bone density.
Others  
Metabolic or Endocrine Disease  
/
HY-P3069 γ-Neuropeptide (rabbit)
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-NP134 Flagellin from S. typhimurium
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases.
Toll-like Receptor (TLR)   MyD88   NF-κB   Interleukin Related   IFNAR  
Inflammation or Immune System Disease   Melanoma  
/
HY-P3497A Fmoc-Cys-Asp10 TFA
Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker, involves in the synthesis of releasable oligopeptide linker. Releasable oligopeptide linker can be used to deliver agent to a bone fracture-homing oligopeptide and reduces fractured femur healing times.
Amino Acid Derivatives  
/
HY-N4019 Maohuoside A
Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways.
TGF-β Receptor  
Metabolic or Endocrine Disease   Pancreatic Cancer   Lung Fibrosis  
/
HY-P99748 Nadecnemab
Nadecnemab is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab can be used for research of osteoarthritis of the knee/pain.

Species: Human

TGF-β Receptor  
Inflammation or Immune System Disease  
/
HY-N15723 Dipsacus saponin A
Dipsacus saponin A is an orally active triterpenoid saponin found in the roots of Dipsacus asper. Dipsacus saponin A promotes bone repair by regulating osteoblast activity and inhibiting osteoclast function. Dipsacus saponin A is promising for research of bone diseases such as fracture healing and osteoporosis.
Others  
/
HY-P3497 Fmoc-Cys-Asp10
Fmoc-Cys-Asp10 is a non-releasable oligopeptide linker, involves in the synthesis of releasable oligopeptide linker. Releasable oligopeptide linker can be used to deliver agent to a bone fracture-homing oligopeptide and reduces fractured femur healing times.
Amino Acid Derivatives  
/
HY-P10809 VAMP
VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 1.00 μM and a Kd of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes.
Dipeptidyl Peptidase  
Glucose Metabolism  
/
HY-B0148S Risedronic acid-d4
Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid (HY-B0148). Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC50 of 20.3 μM).
Isotope-Labeled Compounds   Parasite   Apoptosis  
Cancer   Infection   Metabolic or Endocrine Disease  
/
HY-P0090S Calcitonin-13C6,15N4 (salmon) TFA
Calcitonin-13C6,15N4 (salmon) (Salmon calcitonin-13C6,15N4) TFA is 13C and 15N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
CGRP Receptor  
Metabolic or Endocrine Disease  
/
HY-P2588 Osteocalcin (human)
Osteocalcin (Osteocalcin (1-49)) (human) is a vitamin K-dependent bone specific protein. Osteocalcin (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Breast Cancer  
/
HY-NP143 Nerve Growth Factor 2.5S,murine submaxillary gland
Nerve Growth Factor 2.5S,murine submaxillary gland is a neurotrophic polypeptide and protein growth factor isolated from murine submaxillary glands. Nerve Growth Factor 2.5S,murine submaxillary gland increases the survival rate, phagocytic capacity and superoxide anion production level of mouse cells. Nerve Growth Factor 2.5S,murine submaxillary gland acts through cell membrane surface receptors to mediate the differentiation and maintenance of adrenergic neurons in the sympathetic nervous system. Nerve Growth Factor 2.5S,murine submaxillary gland loses its activity and undergoes dimer dissociation due to oxidation; it remains active after modification of specific tryptophan residues, while its tyrosine residues are not essential for activity. Nerve Growth Factor 2.5S,murine submaxillary gland may play a role in the inflammatory process.
Reactive Oxygen Species (ROS)   Adrenergic Receptor  
Inflammation or Immune System Disease  
/
HY-P0284A C-telopeptide TFA
C-telopeptide TFA is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD). C-telopeptide TFA can be used in studies related to postmenopausal osteoporosis.
MMP  
Osteoporosis  
/
HY-B0633E Hyaluronic acid, low endotoxin
Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating disaccharide units containing low levels of endotoxin. Hyaluronic acid is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid activates PI3K-Akt signaling. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid can lubricate the corneal endothelium. Hyaluronic acid can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases.
Endogenous Metabolite   CD44   Bacterial   Akt   PI3K  
Cancer   Inflammation or Immune System Disease   Visual System Disease   Liver Disease   Osteoarthritis  
/
HY-N0943 (-)-Epiafzelechin
(−)-Epiafzelechin is a COX-1 inhibitor with an IC50 of approximately 15 μM against COX-1 activity. (−)-Epiafzelechin also exhibits DPPH free radical scavenging activity, with an EC50 of 20.9 μM. (−)-Epiafzelechin promotes osteoblast differentiation by increasing ALP activity, ECM collagen content and Runx2 expression, while reducing the growth of osteoclast precursors and RANKL-induced TRAP activity, thereby regulating the bone remodeling process. (−)-Epiafzelechin alleviates ovariectomy-induced bone loss. (−)-Epiafzelechin can be used in studies related to bone remodeling, postmenopausal osteoporosis, inflammatory responses and oxidative stress.
COX   Free Radical Scavengers  
Oxidative Stress and Inflammation   Osteoporosis  
/
HY-W250151 Leishman's stain
Leishman's stain is an essential staining tool for for staining of the peripheral blood and bone marrow smears (displayed pale bluish-grey to deep blue under oil-immersion lens).
Fluorescent Dye  
/
HY-B0631S Alendronic acid-d6
Alendronic acid-d6 is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease.
Isotope-Labeled Compounds  
Cancer  
/
HY-P1520A Prolactin Releasing Peptide (1-31), human acetate
Prolactin Releasing Peptide (1-31), human (acetate) is a high affinity GPR10 ligand that causes the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with Ki values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis.
GnRH Receptor  
Neurological, Eye or Ear Disease  
/
HY-P11208B mNLS-CPP-scramble TFA
mNLS-CPP-scramble (TFA) is the trifluoroacetate salt of mNLS-CPP-scramble (HY-P11208A). mNLS-CPP-scramble is a negative control peptide of mNLS-CPP-WSTF. mNLS-CPP-scramble is promising for research of chronic inflammatory diseases (e.g., MASH, osteoarthritis).
GABA Receptor  
Inflammation or Immune System Disease  
/
HY-P10289A Neuropeptide W-30 (rat) acetate
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-N2236 Dipsanoside B
Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipasandin B shows s an anti-osteoarthritis effect. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc.
Others  
Infection  
/
HY-N0390S3 L-Glutamine-13C5,15N2,d5
L-Glutamine-13C5,15N2,d5 is the deuterium, 13C-, and 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N0684S Vitamin K1-d7
Vitamin K1-d7 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-P1245 Neuropeptide SF (human)
Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
CRFR  
/
HY-N0684S3 Vitamin K1-13C6
Vitamin K1-13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-N0390S4 L-Glutamine-5-13C
L-Glutamine-5-13C is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P99627 Frunevetmab
Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats.

Species: Felcat

Trk Receptor  
Inflammation or Immune System Disease  
/
HY-P1520 Prolactin Releasing Peptide (1-31), human
Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with Ki values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis.
GnRH Receptor  
Neurological, Eye or Ear Disease  
/
HY-P4588 (Glu17,21,24)-Osteocalcin (1-49) (human)
(Glu17,21,24)-Osteocalcin (1-49) (human) is a bone-specific protein involved in bone formation and glucose metabolism.
GLUT  
Metabolic or Endocrine Disease  
/
HY-N9331 Cimicifugoside H-1
Cimicifugoside H-1, a cyclolanostanol xyloside, is a major constituent of C. foetida L. extract. Cimicifugoside H-1 inhibits bone resorption and ovariectomy-induced bone loss.
Others  
Metabolic or Endocrine Disease  
/
HY-P991748 Anti-Human/Mouse Amphiregulin Antibody (AR37)
Anti-Human/Mouse Amphiregulin Antibody (AR37) is an antibody targeting amphiregulin (AREG), with a Kd value of 3.24 nM for the human protein and 6.40 nM for the mouse protein. Anti-Human/Mouse Amphiregulin Antibody (AR37) blocks the autocrine activation of the AREG-EGFR-ERK axis. Anti-Human/Mouse Amphiregulin Antibody (AR37) inhibits the proliferation and migration of ovarian cancer cells. Anti-Human/Mouse Amphiregulin Antibody (AR37) prolongs the survival of immunocompetent mice bearing syngeneic ovarian cancer tumors. Anti-Human/Mouse Amphiregulin Antibody (AR37) is applicable to ovarian cancer-related research.

Species: Human/Mouse

EGFR   ERK  
Ovarian Cancer  
/
HY-W008951 Ethylenediaminetetra(methylenephosphonic acid)
Ethylenediaminetetramethylenephosphonic acid (EDTMP) is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with 153Sm and 177Lu. Ethylenediaminetetramethylenephosphonic acid is used to study palliative therapy for pain associated with multiple bone metastatic cancers.
Radionuclide-Drug Conjugates (RDCs)  
Pain   Multiple Myeloma  
/
HY-13948BS Angiotensin II human-13C6,15N TFA
Angiotensin II human-13C6,15N TFA (Ang II-13C6,15N TFA) is 13C- and 15N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions.
Isotope-Labeled Compounds  
Cancer  
/
HY-P99195 Fasinumab
Fasinumab (Anti-Human NGF) is a human IgG4 monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies.

Species: Human

Trk Receptor  
Inflammation or Immune System Disease  
/
HY-W110927 Alizarin Red S Indicator (4.3-6.3), IND
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research.
Biochemical Assay Reagents   Fluorescent Dye  
/
HY-P99677 Izenivetmab
Izenivetmab (ZTS-00075623) is an anti-NGFB IgG2κ monoclonal antibody. Izenivetmab shows anti-inflammatory and analgesic effects by targeting anti-nerve growth factor (NGF). Izenivetmab can be used for the research of osteoarthritis.

Species: Canlupfam

Trk Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Osteoarthritis  
/
HY-NP161 Mussel Adhesive Protein
Mussel Adhesive Protein (MAP) is a mussel-derived mucin. Mussel Adhesive Protein can be formulated into a waterproof, eco-safe adhesive that bonds materials such as glass, plastic, metal and wood to bones or teeth, biological organisms, and other chemicals or molecules.
Biochemical Assay Reagents  
/
HY-W088068 Wright's stain
Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities.
Fluorescent Dye  
/
HY-B2162D Chondroitin sulfate (from chicken)
Chondroitin sulfate (from chicken) (Chondroitin polysulfate (from chicken)) is an orally active, sulfated linear polysaccharide extracted from chickens, which belongs to glycosaminoglycans. Chondroitin sulfate (from chicken) reduces the phosphorylation levels of ERK1/2 and p38MAPK, inhibits the expression of inflammatory cytokines and MMP, and downregulates the levels of IL-1β, IL-6, TNF-α and PGE2. Chondroitin sulfate (from chicken) improves motor function, protects cartilage tissue, reverses chondrocyte aggregation, and regulates the structure of intestinal flora. Chondroitin sulfate (from chicken) can be used in research related to osteoarthritis.
ERK   p38 MAPK   Interleukin Related   TNF Receptor   Prostaglandin Receptor   MMP   Endogenous Metabolite  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P99398 Setrusumab
Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer.

Species: Human

Others  
Cancer   Inflammation or Immune System Disease  
/
HY-B2200 Calcium citrate tetrahydrate, 99%
Calcium citrate tetrahydrate, 99% exhibits the ability to release more calcium ions in a short time therefore allowing a high activity, and a high concentration of calcium ions that can stimulate bone formation.
Environmental Pollutants   Calcium Channel   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-N6588 3,4,5-Tricaffeoylquinic acid
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.
Akt   NF-κB  
Inflammation or Immune System Disease  
/
HY-B2162C Chondroitin sulfate (from pig)
Chondroitin sulfate (from pig) (Chondroitin polysulfate (from pig)) is a sulfated linear polysaccharide extracted from pigs, which belongs to glycosaminoglycans. Chondroitin sulfate (from pig) exerts inconsistent inhibitory effects on the resorptive activity of human osteoclasts. Chondroitin sulfate (from pig) can be used in studies related to osteoarthritis.
Endogenous Metabolite  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P990635 NGM-120
NGM-120 is a fully humanized IgG1 monoclonal antibody targeting GFRAL, which functions by blocking the GDF15-GFRAL axis. NGM-120 reduces serum GDF15 levels, increases body weight, expands central memory and proliferative CD8+ T cell populations, and decreases immunosuppressive and naive regulatory T cell populations. NGM-120 can be used for research on advanced prostate cancer.

Species: Human

TGF-β Receptor  
Prostate Cancer  
/
HY-N8307 Syringaresinol
Syringaresinol is a lignan-type phytochemical with anti-inflammatory activities. Syringaresinol inhibits the NF-κB and AKT signaling pathway in IL-1β-activated mouse chondrocytes. Syringaresinol increases phosphorylation of AMPK, eNOS, and intracellular Ca2+ levels in HUVECs. Syringaresinol attenuates osteoarthritis progression in mice with Destabilization of the Medial Meniscus (DMM)-induced osteoarthritis. Syringaresinol can be used for the study of osteoarthritis (OA).
NO Synthase   NF-κB   Akt   AMPK   Calcium Channel  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis  
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HY-W145486 Calcium gluconate
Calcium gluconate is an orally effective calcium salt supplement. Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury.
Environmental Pollutants   Biochemical Assay Reagents  
Postoperative Pain   Acute Lung Injury   Osteoporosis  
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HY-D1537 Dibenzocyclooctyne-Cy5.5
Dibenzocyclooctyne-Cy5.5 (DBCO-Cy5.5) is a fluorescent dye. Dibenzocyclooctyne-Cy5.5 can be used to syntheses calcium-binding near-infrared fluorescent nanoprobe for bone tissue imaging.
Fluorescent Dye  
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HY-124081 N-Oleoyl-L-serine
N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development.
Apoptosis  
Metabolic or Endocrine Disease  
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HY-N0442 5-O-Methylvisammioside
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the NF-κB pathway.
NF-κB   p38 MAPK   JNK   Src   TNF Receptor   NOD-like Receptor (NLR)   Amyloid-β   MEK   ERK   Ferroptosis   VEGFR   Anaplastic lymphoma kinase (ALK)   Reactive Oxygen Species (ROS)  
Liver Cancer   Depression   Hyperuricemia   Ulcerative Colitis   Liver Injury  
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HY-P99781 Plozalizumab
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

CCR  
Cancer   Inflammation or Immune System Disease  
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HY-W009154 3,6-Dibromocarbazole
3,6-Dibromocarbazole is a glucocorticoid receptor (GR) inhibitor and Environmental pollutant. 3,6-Dibromocarbazole induces abnormal development of zebrafish embryos and disrupts the neurohormonal function of the hypothalamic-pituitary-adrenal axis in zebrafish larvae. 3,6-Dibromocarbazole increases the α-diversity of soil bacteria, alters community structure, enhances interspecific competition, regulates metabolic functions, and changes the abundance of genes related to nitrogen fixation, nitrification and carbon cycling. 3,6-Dibromocarbazole exerts endocrine-disrupting potential by interfering with the gluconeogenesis pathway.
Environmental Pollutants   Glucocorticoid Receptor   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
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HY-P9992 Pelgifatamab
Peligifatamab is a PSMA-targeted α-radioimmunoconjugate with an EC50 of 1.2 nM against human targets. Peligifatamab induces DNA damage, DNA double-strand breaks, cell cycle arrest and apoptosis (Apoptosis) in PSMA-positive prostate cancer cells. Peligifatamab reduces cell viability in a manner dependent on cellular PSMA expression levels. Peligifatamab inhibits tumor growth and tumor-induced abnormal bone growth in prostate cancer bone metastasis models. Peligifatamab exhibits antitumor efficacy in subcutaneous prostate cancer models and xenograft models. Peligifatamab can be used for the research of metastatic castration-resistant prostate cancer.

Species: Human

PSMA   Apoptosis  
Castration-Resistant Prostate Cancer  
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HY-12071G LDN193189 (GMP)
LDN193189 GMP is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva.
Organoid   TGF-β Receptor  
Cancer  
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HY-N8847 α-Ionone
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro.
Environmental Pollutants   Apoptosis   YAP   Large Tumor Suppressor (LATS)   Hippo (MST)   Olfactory Receptor  
Cancer   Digestive System Disease   Digestive System Inflammation  
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HY-B2162B Chondroitin sulfate sodium (from bovine)
Chondroitin sulfate (Chondroitin polysulfate) sodium (from bovine)) is a sulfated linear polysaccharide extracted from bovine sources, belonging to glycosaminoglycans. Chondroitin sulfate sodium (from bovine) inhibits osteoclast-mediated bone resorption and exhibits antioxidant activity, which is negatively correlated with molecular weight. Chondroitin sulfate sodium (from bovine) can be used in studies related to osteoarthritis.
Free Radical Scavengers   Reactive Oxygen Species (ROS)   Endogenous Metabolite  
Inflammation or Immune System Disease   Osteoarthritis  
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HY-108786 Asfotase alfa
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 / knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP).

Species: Human

Phosphatase  
Metabolic or Endocrine Disease  
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HY-N0390S6 L-Glutamine-13C5,15N2
L-Glutamine-13C5,15N2 is the 13C- and 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Isotope-Labeled Compounds   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-158231 Polyether F127 Diacrylate
Polyether F127 Diacrylate (F127DA) is an acrylated polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer. Polyether F127 Diacrylate rapidly crosslinks and cures into a gel under ultraviolet or visible light with the action of a photoinitiator. Polyether F127 Diacrylate exhibits excellent thermogelation properties and favorable biosafety. Polyether F127 Diacrylate can upregulate the Integrin-FAK pathway, enhance collagen production, increase the protein and gene expression levels of COL-1/SCX, and promote fibroblastic differentiation of periodontal ligament stem cells. Polyether F127 Diacrylate promotes periodontal ligament regeneration and reduces abnormal healing in a rat model of delayed replanted teeth. Polyether F127 Diacrylate promotes functional osteochondral regeneration in a rat model of osteoarthritis. Polyether F127 Diacrylate supports adipose tissue survival, rendering it suitable for breast reconstruction applications. Polyether F127 Diacrylate can be used in studies related to periodontal ligament injury, breast defect and osteoarthritis.
Integrin   FAK  
Inflammation or Immune System Disease   Osteoarthritis  
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HY-P99297 Bedinvetmab
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.

Species: Canine

Trk Receptor  
Inflammation or Immune System Disease   Osteoarthritis  
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HY-P99186 Blosozumab
Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis.

Species: Human

Others  
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HY-D1249 Calcein (mixture of isomers)
Calcein (mixture of isomers), Calcein (HY-D0040) Derivative, is a fluorescent dye (Ex/Em = 495/515 nm). Calcein (mixture of isomers) can be used for the researches for live cell staining, calcium ion detection, bone fluorescence labeling and membrane permeability leakage detection.
Fluorescent Dye  
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HY-108775A Sodium thiosulfate (99%, water≤1.0%)
Sodium thiosulfate (Sodium hyposulfite) is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease.
COX   β-catenin   NF-κB   Interleukin Related   GSK-3  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Breast Cancer   Melanoma   Antioxidant Agent   Osteoarthritis  
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HY-P99721 Lutikizumab
Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
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HY-P5558 KLTWQELYQLKYKGI
KLTWQELYQLKYKGI is a VEGF mimetic peptide designed based on the VEGF helix sequence 17-25, with the ability to activate VEGF receptors and exert pro-angiogenic biological activity. KLTWQELYQLKYKGI effectively promotes the attachment, spreading and proliferation of human umbilical vein endothelial cells. KLTWQELYQLKYKGI enhances the proliferation, migration and osteogenic differentiation of bone marrow stromal cells (BMSCs). KLTWQELYQLKYKGI synergistically accelerates angiogenesis and bone regeneration in rat cranial defect models. KLTWQELYQLKYKGI can be used for the research of brain tissue engineering and traumatic brain injury repair and biomaterials for bone tissue engineering and bone repair.
VEGFR  
Neurological, Eye or Ear Disease  
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HY-N0390R L-Glutamine (Standard)
L-Glutamine (Standard) is the analytical standard of L-Glutamine (HY-N0390). This product is intended for research and analytical applications. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.

Source: Human Blood, Breast Milk, Cerebrospinal Fluid (CSF), Feces, Saliva, Sweat, Urine

Reference Standards   mGluR   Ferroptosis   Environmental Pollutants   Endogenous Metabolite   HIF/HIF Prolyl-Hydroxylase   mTOR   STAT   NF-κB  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-P0084 Cyclic somatostatin
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease.
Endogenous Metabolite  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
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HY-P2273 Calcitonin (human)
Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research.
CGRP Receptor  
Metabolic or Endocrine Disease  
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HY-P75472 BMP-5 Protein, Human (HEK293, hFc)
Bone morphogenetic protein 5 (BMP-5) is a pleiotropic ligand protein belonging to the TGFβ family, which is mainly expressed in the lung and liver. After BMP-5 silencing, the activity of p38/ERK signaling pathway can be down-regulated to inhibit chondrocyte senescence and apoptosis and knee arthritis (OA). Bmp-5 initiates typical BMP signaling cascades by binding to type I receptor BMPR1A and type II receptor BMPR2, or triggers signals through atypical pathways such as MAPK p38 signaling cascades to promote chondrogenic differentiation.

Species: Human; Source: HEK293

Cytokines and Growth Factors TGF-beta Superfamily Bone Morphogenetic Proteins (BMPs) Bone Morphogenetic Protein 5

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HY-P7674 BSP2 Protein, Mouse (HEK293, His)
BSP2 Protein, Mouse (HEK293, His) is a recombinant mouse bone sialoprotein 2 produced in HEK293 cells. Bone Sialoprotein 2, one of the major bone matrix proteins, with its previously known role in osseous tissue degradation, has been recently proven to play a role in the nucleation of hydroxyl apatite during osseous tissue mineralization.

Species: Mouse; Source: HEK293

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HY-P79077 BMP-3 Protein, Human
BMP-3 Protein, a TGF-beta superfamily member, crucially influences early skeletal formation and acts as a bone density negative regulator. It counteracts osteogenic BMPs, hindering osteoprogenitor differentiation. BMP-3 initiates signaling via ACVR2B, activating SMAD2-dependent and SMAD-independent pathways, including TAK1 and JNK. Structurally, it forms homodimers with disulfide bonds, interacting with ACVR2B to regulate functions. BMP-3 Protein, Human is the recombinant human-derived BMP-3 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Cytokines and Growth Factors TGF-beta Superfamily Bone Morphogenetic Proteins (BMPs) Bone Morphogenetic Protein 3 (BMP-3/Osteogenin)

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HY-P72241 IBSP Protein, Human (His-SUMO)
The IBSP protein has a strong affinity for hydroxyapatite and plays a crucial role in mineralized matrix formation, indicating its overall nature in this regard. Its tight binding suggests an important role in cell-matrix interactions, particularly in promoting RGD-dependent cell attachment. IBSP Protein, Human (His-SUMO) is the recombinant human-derived IBSP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Human; Source: E. coli

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HY-P700026AF Animal-Free BMP-3 Protein, Human (His)
BMP-3 Protein, a TGF-beta superfamily member, crucially influences early skeletal formation and acts as a bone density negative regulator. It counteracts osteogenic BMPs, hindering osteoprogenitor differentiation. BMP-3 initiates signaling via ACVR2B, activating SMAD2-dependent and SMAD-independent pathways, including TAK1 and JNK. Structurally, it forms homodimers with disulfide bonds, interacting with ACVR2B to regulate functions. Animal-Free BMP-3 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-3 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Species: Human; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins TGF-beta Superfamily Bone Morphogenetic Proteins (BMPs) Bone Morphogenetic Protein 3 (BMP-3/Osteogenin)

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HY-P700028AF Animal-Free BMP-5 Protein, Human (His)
BMP-5 protein is an important member of the TGF-β superfamily and is essential for cartilage and bone formation as well as neurogenesis. It activates canonical BMP signaling through BMPR1A and BMPR2 and phosphorylates SMAD1/5/8 for gene transcription regulation. Animal-Free BMP-5 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-5 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Species: Human; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins TGF-beta Superfamily Bone Morphogenetic Proteins (BMPs) Bone Morphogenetic Protein 5

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HY-P72103 BGLAP Protein, Mouse (His-SUMO)
The BGLAP protein, in its carboxylated state, forms an important part of the bone matrix and acts as a negative regulator of bone formation. It limits bone formation and preserves processes such as resorption and mineralization. BGLAP Protein, Mouse (His-SUMO) is the recombinant mouse-derived BGLAP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Mouse; Source: E. coli

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HY-P72104 BGLAP Protein, Rat (GST)
BGLAP protein in its carboxylated form negatively regulates bone formation while promoting bone resorption and mineralization.The carboxylated form has a strong affinity for apatite and calcium.BGLAP Protein, Rat (GST) is the recombinant rat-derived BGLAP protein, expressed by E.coli , with N-GST labeled tag.

Species: Rat; Source: E. coli

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HY-P82477 Axin 2 Antibody (YA2222)
Axin 2 Antibody (YA2222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Axin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86653 Alkaline phosphatase Antibody (YA6345)
Alkaline phosphatase Antibody (YA6345) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Alkaline phosphatase.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82540 BMP-4 Antibody (YA2285)
BMP-4 Antibody (YA2285) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BMP-4.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86447 BMP-2 Antibody (YA6139)
BMP-2 Antibody (YA6139) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BMP-2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87193 Decorin Antibody (YA6881)
Decorin Antibody (YA6881) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Decorin.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85061 BMP-4 Antibody (YA4753)
BMP-4 Antibody (YA4753) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BMP-4.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P87773 BMP-4 Antibody (YA7458)
BMP-4 Antibody (YA7458) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to BMP-4.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811637 BMP10 Antibody
BMP10 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to BMP10.

Host: Rabbit; Reactivity: Human

Polyclonal Antibodies Primary Antibodies

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HY-P82477A Axin 2 Antibody (YA2222)(PBS only)
Axin 2 Antibody (YA2222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Axin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86653A Alkaline phosphatase Antibody (YA6345)(PBS only)
Alkaline phosphatase Antibody (YA6345) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Alkaline phosphatase.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86794 Bone sialoprotein 2 Antibody (YA6487)
Bone sialoprotein 2 Antibody (YA6487) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bone sialoprotein 2.

Host: Rabbit; Reactivity: Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86813 CHD8 Antibody (YA6506)
CHD8 Antibody (YA6506) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CHD8.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-K0357 Mouse Mature B Cell Negative Selection Kit

MCE Mouse Mature B Cell Negative Selection Kit enables the efficient isolation of mature B cells from single-cell suspensions prepared from mouse spleen, lymph nodes, or bone marrow. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells (non-B cells), followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of mouse mature B cells.

Cell Biology Cell Isolation

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HY-K0361 Mouse Pan B Cell Negative Selection Kit

MCE Mouse Pan B Cell Negative Selection Kit enables the efficient isolation of total B cells from mouse spleen, lymph nodes, bone marrow, or peritoneal lavage fluid. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells (non-B cells), followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of mouse B Cells.

Cell Biology Cell Isolation

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HY-K0614 Oil Red O Staining Kit for Cell Smears

MCE Oil Red O Staining Kit for Cell Smears effectively stains lipid droplets of various sizes, including smaller lipid droplets, and preferentially adsorbs dye from the solvent. It is suitable for staining oil red O in cell smears, bone marrow smears, fluid smears, blood smears, and other samples. When using the kit, specimens should not be fixed with fixatives containing ethanol. If fixation is required, 10% formalin can be used. The positive staining result for fat typically appears orange-yellow to red, with the exact color varying depending on the lipid concentration.

Cell Biology Cell Analysis Staining Kit

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HY-K0617 Wright-Giemsa Stain Kit

Wright stain combines the acidic dye eosin (Eosin) with the basic dye methylene blue (Methylene Blue) to differentiate cellular structures. Giemsa stain consists of Azure II and eosin. Although the two stains have broadly similar staining mechanisms and color reactions, Giemsa stains the cytoplasm more strongly and shows its degree of basophilia more clearly. In blood and bone marrow specimens, it provides particularly effective staining of azurophilic, eosinophilic, and basophilic granules. However, its relatively intense nuclear staining can make fine intranuclear details difficult to distinguish. Because their staining properties are complementary, the two stains are often used together to offset their respective limitations.

Cell Biology Cell Analysis Staining Kit

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HY-K3037 McCoy’s 5A (Modified) Medium

MCE McCoy's 5A Modified Medium is a nutrient-rich medium designed for culturing a wide range of cell types, particularly suitable for supporting the growth of primary cells. It is widely used for the culture of various mammalian cells, including normal and tumor-derived cells, epithelial cells, fibroblasts, bone marrow cells, and other cell types. The product specifications are based on the 500 mL format, and larger volume packages are provided as multiples of this standard specification.

Cell Biology Cell Culture Basal Cell Culture Media

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Keywords

neuro-skeletal axis | bone innervation | sympathetic nervous system | sensory nerves | bone remodeling | fracture healing | osteoarthritis | bone pain