C2 - complement component 2 (within H-2S) Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12263

Summary

This gene encodes component C2 of the classical pathway of the Complement System. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the Complement System. Mice lacking the encoded protein are found to be more susceptible to Bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]

C2 Products (1)

mRNA Protein Name
NM_013484.2 NP_038512.2 complement C2 preproprotein
Protein Preferred Names Protein Names

complement C2

  • MHC complement component C2

  • classical-complement pathway C3/C5 convertase

  • complement component C2

  • complement factor C2

Recombinant C2 Proteins

Cat. No. Product Name Accession Purity
HY-P74374 C2/Complement C2 Protein, Mouse (HEK293, His) P21180-1 (A19-L760) ≥ 95%, as determined by reducing SDS-PAGE.

Orthologs Information

Species Symbol Source ID
Homo sapiens C2 NCBI NCBI:717