2. Gene
  3. VHL - von Hippel-Lindau tumor suppressor Gene

VHL - von Hippel-Lindau tumor suppressor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 494000 | Gene type: protein coding

About VHL

VHL Products(1)

mRNA Protein Name
NM_001008552.1 NP_001008552.1 von Hippel-Lindau disease tumor suppressor
Protein Preferred Names Protein Names

von Hippel-Lindau disease tumor suppressor

pVHL

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13001 Quizartinib 99.01% Yes
HY-14217 Quizartinib dihydrochloride 99.81% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-162362 MS8709 Degrader 98.91% Phase 1
Pre-clinical Phase
Bioactive Molecules (278)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100947 VH-298 Inhibitor 99.78% Unkown
HY-130604 DT2216 99.97% Unkown
HY-120217 VH032 99.64% Unkown
HY-42424 (S,R,S)-AHPC-Me hydrochloride 99.59% Unkown
HY-111997 VH285-PEG4-C4-Cl ≥98.0% Unkown
HY-137516 LC-2 Inhibitor 98.04% Unkown
HY-101763A (S,R,S)-AHPC monohydrochloride 99.83% Unkown
HY-130492 ARCC-4 Inhibitor 99.88% Unkown
HY-18728 STF-31 99.79% Unkown
HY-132296 GSK215 Inhibitor 99.85% Unkown
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-151623 ACBI2 Inhibitor 99.76% Unkown
HY-145479 PROTAC AR-V7 degrader-1 Inhibitor 99.34% Unkown
HY-148030 XL01126 Inhibitor 99.81% Unkown
HY-119932 PROTAC FAK degrader 1 Inhibitor 99.25% Unkown
HY-113491 3-Phosphoglyceric acid 99.78% Unkown
HY-130602 MS432 Inhibitor 99.78% Unkown
HY-125878 PROTAC SGK3 degrader-1 Inhibitor 99.89% Unkown
HY-112078 (S,R,S)-AHPC-Me 99.48% Unkown
HY-103601 (S,R,S)-AHPC-PEG4-N3 99.93% Unkown
HY-153863 MS934 Degrader 98.82% Unkown
HY-103598 (S,R,S)-AHPC-PEG3-N3 99.67% Unkown
HY-130257 CP5V Inhibitor 99.31% Unkown
HY-44432 Navitoclax-piperazine Inhibitor 99.73% Unkown
HY-130271 (S,R,S)-AHPC-PEG5-COOH 99.80% Unkown
HY-129937A GNE-987 Inhibitor 99.91% Unkown
HY-136262 CRBN-6-5-5-VHL 99.98% Unkown
HY-153188 JNJ-1013 99.80% Unkown
HY-125905 VH032-cyclopropane-F 99.92% Unkown
HY-112495 VH032-PEG5-C6-Cl 99.93% Unkown
HY-103600 (S,R,S)-AHPC-PEG1-N3 98.18% Unkown
HY-103602 (S,R,S)-AHPC-PEG3-NH2 hydrochloride 99.01% Unkown
HY-125834 GMB-475 98.98% Unkown
HY-145162 SHP2-D26 Inhibitor 95.03% Unkown
HY-125845A (S,S,S)-AHPC hydrochloride 99.42% Unkown
HY-128845 PROTAC CRBN Degrader-1 99.84% Unkown
HY-141438 SIM1 Inhibitor 99.57% Unkown
HY-138669 C004019 Degrader 99.37% Unkown
HY-145816A JPS016 TFA 98.70% Unkown
HY-103604A (S,R,S)-AHPC-PEG4-NH2 99.51% Unkown
HY-133737 PROTAC BRD4 Degrader-5 Inhibitor 99.93% Unkown
HY-100746 STF-62247 Inducer 98.69% Unkown
HY-103603 (S,R,S)-AHPC-PEG2-NH2 hydrochloride 99.77% Unkown
HY-128756 SIAIS178 Inhibitor 99.36% Unkown
HY-103599 (S,R,S)-AHPC-PEG2-N3 99.74% Unkown
HY-126456 (S,R,S)-AHPC-propargyl 99.48% Unkown
HY-132857A ZXH-4-130 TFA 99.71% Unkown
HY-153119 TMX-4153 98.96% Unkown
HY-128767 VH032-PEG3-acetylene 98.14% Unkown
HY-130979 EED226-COOH 98.53% Unkown
HY-130815A MAK683-CH2CH2COOH hydrochloride Inhibitor 98.03% Unkown
HY-47070 VH 101, acid 98.37% Unkown
HY-B2171A Carubicin hydrochloride Inducer 98.33% Unkown
HY-130798 (S,R,S)-AHPC-amido-C5-acid 99.58% Unkown
HY-133045 VHL Ligand 8 98.04% Unkown
HY-156106 VHL-IN-1 99.78% Unkown
HY-111905 BRD7-IN-1 Inhibitor 99.77% Unkown
HY-111663 VL285 98.84% Unkown
HY-148896 (S,R,S)-AHPC-C2-PEG3-BCN 99.22% Unkown
HY-137346 DD-03-156 Degrader 99.63% Unkown
HY-139218 (S,R,S)-AHPC-Me-C6-NH2 99.14% Unkown
HY-148671 (S,R,S)-AHPC-amido-C7-acid 98.28% Unkown
HY-152154 Nampt degrader-2 99.41% Unkown
HY-130714 TD-165 Inhibitor 99.41% Unkown
HY-103605 (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% Unkown
HY-114323 PROTAC FLT-3 degrader 1 99.74% Unkown
HY-123109 (S,R,S)-AHPC-Boc 95.21% Unkown
HY-103604 (S,R,S)-AHPC-PEG4-NH2 hydrochloride 98.06% Unkown
HY-103607 (S,R,S)-AHPC-PEG2-C4-Cl 98.21% Unkown
HY-42424A (S,R,S)-AHPC-Me dihydrochloride 99.84% Unkown
HY-136163 (S,R,S)-AHPC-C2-NH2 dihydrochloride 98.63% Unkown
HY-130845A AR antagonist 1 hydrochloride Antagonist 99.53% Unkown
HY-131388 ABM-14 98.17% Unkown
HY-131865 SJF-1521 Degrader 99.65% Unkown
HY-133487B (S,R,S)-AHPC-C8-NH2 97.04% Unkown
HY-130849 (S,R,S)-AHPC-Me-C5-COOH 96.87% Unkown
HY-103608 (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl 99.89% Unkown
HY-130711B (S,R,S)-AHPC-C3-NH2 hydrochloride 96.38% Unkown
HY-145815A JPS014 TFA 98.40% Unkown
HY-150803 VHL Ligand 14 99.93% Unkown
HY-47851 VH 101, thiol 98.66% Unkown
HY-145264 OARV-771 Inhibitor 98.33% Unkown
HY-155815 MS9715 Inhibitor / Unkown
HY-114176B (S,R,S)-AHPC-C4-NH2 dihydrochloride / Unkown
HY-130991 K-Ras ligand-Linker Conjugate 6 / Unkown
HY-136183 (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride 98.16% Unkown
HY-136184 (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 99.01% Unkown
HY-122702 PEG6-(CH2CO2H)2 ≥95.0% Unkown
HY-123109A (S,S,S)-AHPC-Boc 97.21% Unkown
HY-130716 Thalidomide-NH-C10-COOH Inducer 97.50% Unkown
HY-131295 PD0325901-O-C2-dioxolane Inhibitor 98.76% Unkown
HY-131866 (S,R,S)-CO-C2-acid ≥98.0% Unkown
HY-136006B (S,R,S)-AHPC-C6-NH2 98.03% Unkown
HY-138550A (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA 99.42% Unkown
HY-138678 (R,S,S)-VH032 ≥95.0% Unkown
HY-141797 MS33 Inhibitor / Unkown
HY-151227 VL285 Phenol 98.56% Unkown
HY-156152A CARM1 degrader-1 hydrochloride Degrader / Unkown
HY-156568 SMD-3040 Degrader 99.91% Unkown
HY-156568A SMD-3040 TFA Degrader 99.90% Unkown
HY-158142 PROTAC TYK2 degrader-1 Degrader / Unkown
HY-162250 MS8847 Inhibitor / Unkown
HY-162608 PROTAC JAK1 degrader 1 Degrader / Unkown
HY-163897 PROTAC NCOA4 degrader-1 Inhibitor 99.42% Unkown
HY-130815 MAK683-CH2CH2COOH Inhibitor / Unkown
HY-131959 (S,R,S)-AHPC-PEG5-Boc 95.29% Unkown
HY-136165 (S,R,S)-AHPC-PEG3-propionic acid 97.03% Unkown
HY-103602A (S,R,S)-AHPC-PEG3-NH2 99.26% Unkown
HY-103603A (S,R,S)-AHPC-PEG2-NH2 95.41% Unkown
HY-103603B (S,R,S)-AHPC-PEG2-NH2 dihydrochloride ≥95.0% Unkown
HY-130642 (S,R,S)-AHPC-Me-C10-Br 97.21% Unkown
HY-130707 K-Ras ligand-Linker Conjugate 3 / Unkown
HY-130816 (S,R,S)-AHPC-O-Ph-PEG1-NH2 96.97% Unkown
HY-130823 K-Ras ligand-Linker Conjugate 5 99.79% Unkown
HY-131387 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 96.12% Unkown
HY-133487A (S,R,S)-AHPC-C8-NH2 hydrochloride / Unkown
HY-136006A (S,R,S)-AHPC-C6-NH2 hydrochloride / Unkown
HY-136164 VH032-OH 99.43% Unkown
HY-156730 KT-333 Degrader / Unkown
HY-103606 (S,R,S)-AHPC-PEG6-C4-Cl 96.24% Unkown
HY-111823 VH032 thiol 95.91% Unkown
HY-114176 (S,R,S)-AHPC-C4-NH2 hydrochloride ≥97.0% Unkown
HY-136257 CMP98 99.72% Unkown
HY-138862 (S,R,S)-AHPC-C1-Br ≥98.0% Unkown
HY-158345 PROTAC VHL-type degrader-1 / Unkown
HY-159798 NR-11c Inhibitor / Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-111905A BRD7-IN-1 free base Inhibitor / Unkown
HY-129775 K-Ras ligand-Linker Conjugate 1 / Unkown
HY-129776 K-Ras ligand-Linker Conjugate 2 / Unkown
HY-129941 (S,R,S)-AHPC-C10-NH2 / Unkown
HY-130711A (S,R,S)-AHPC-C3-NH2 TFA / Unkown
HY-141486 (Rac)-PROTAC PARP/EGFR ligand 1 / Unkown
HY-156744 DBr-1 Degrader / Unkown
HY-159147 SIA​​IS039 / Unkown
HY-168555 YJ1206 / Unkown
HY-114176A (S,R,S)-AHPC-C4-NH2 / Unkown
HY-125846 (S,R,S)-AHPC-PEG1-OTs / Unkown
HY-125906 VHL Ligand-Linker Conjugates 15 / Unkown
HY-129941A (S,R,S)-AHPC-C10-NH2 dihydrochloride / Unkown
HY-130711 (S,R,S)-AHPC-C3-NH2 / Unkown
HY-130822 K-Ras ligand-Linker Conjugate 4 98.76% Unkown
HY-130847 (S,R,S)-AHPC-Me-C10-NH2 96.19% Unkown
HY-133487 (S,R,S)-AHPC-C8-NH2 dihydrochloride / Unkown
HY-136006 (S,R,S)-AHPC-C6-NH2 dihydrochloride / Unkown
HY-136008A (S,R,S)-AHPC-PEG1-NH2 dihydrochloride / Unkown
HY-136055 (S,R,S)-AHPC-C5-COOH Inhibitor 98.81% Unkown
HY-156730B KT-333 diammonium Degrader / Unkown
HY-100947A cis VH-298 / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-103602B (S,R,S)-AHPC-PEG3-NH2 dihydrochloride / Unkown
HY-111824 VH032-thiol-C6-NH2 / Unkown
HY-112078A (S,R,S,R)-AHPC-Me / Unkown
HY-114322A cis-VZ185 Degrader / Unkown
HY-130641 Br-C10-methyl ester 97.87% Unkown
HY-130654 (S,R,S)-AHPC-C2-PEG4-N3 / Unkown
HY-130711C (S,R,S)-AHPC-C3-NH2 dihydrochloride / Unkown
HY-131168 (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH 99.31% Unkown
HY-132857 ZXH-4-130 / Unkown
HY-133046 VHL Ligand-Linker Conjugates 17 / Unkown
HY-136005 VH032-C7-COOH / Unkown
HY-136008 (S,R,S)-AHPC-PEG1-NH2 / Unkown
HY-136163A (S,R,S)-AHPC-C2-NH2 / Unkown
HY-136186 (S,R,S)-AHPC-C7-amine / Unkown
HY-136186B (S,R,S)-AHPC-C7-amine hydrochloride / Unkown
HY-136187 (S,R,S)-AHPC-C5-NH2 / Unkown
HY-136187A (S,R,S)-AHPC-C5-NH2 dihydrochloride / Unkown
HY-137516A LC-2 epimer / Unkown
HY-138678B (S,R,R)-VH032 / Unkown
HY-138861 (S,R,S)-AHPC-C1-NH2 / Unkown
HY-138861A (S,R,S)-AHPC-C1-NH2 hydrochloride 98.08% Unkown
HY-139335 VH 101 phenol-alkylC4-amine dihydrochloride / Unkown
HY-141651 (S,R,S)-AHPC-C3-COOH / Unkown
HY-144323 YF135 Inhibitor / Unkown
HY-145514B dTAGV-1-NEG TFA / Unkown
HY-145715 Azido-PEG2-VHL / Unkown
HY-145815 JPS014 / Unkown
HY-145816 JPS016 / Unkown
HY-145818 JPS035 / Unkown
HY-145819 JPS036 / Unkown
HY-146022 SIAIS117 Inhibitor / Unkown
HY-147174 PROTAC_ERRα Inhibitor 99.71% Unkown
HY-147235 RIPK2-IN-2 Inhibitor / Unkown
HY-147373 DA-PROTAC / Unkown
HY-148406 (S,R,S)-AHPC-C10-NHBoc 98.32% Unkown
HY-155356 YN14 Degrader / Unkown
HY-155506 NAMPT degrader-3 Degrader / Unkown
HY-155643 PROTAC TG2 degrader-1 Inhibitor / Unkown
HY-156152 CARM1 degrader-1 Inhibitor / Unkown
HY-156153 CARM1 degrader-2 Inhibitor / Unkown
HY-156730A KT-333 ammonium Degrader / Unkown
HY-157512 SJF-0661 / Unkown
HY-157590 E3 ligase Ligand-Linker Conjugate 32 / Unkown
HY-157593 E3 ligase Ligand-Linker Conjugate 35 / Unkown
HY-157596 E3 ligase Ligand-Linker Conjugate 40 / Unkown
HY-157597 E3 ligase Ligand-Linker Conjugate 42 / Unkown
HY-157598 E3 ligase Ligand-Linker Conjugate 46 / Unkown
HY-157634 E3 Ligase Ligand-linker Conjugate 91 / Unkown
HY-157752 E3 Ligase Ligand-linker Conjugate 101 / Unkown
HY-157753 E3 Ligase Ligand-linker Conjugate 102 / Unkown
HY-157754 E3 Ligase Ligand-linker Conjugate 103 / Unkown
HY-158036 PROTAC STING Degrader-2 Degrader / Unkown
HY-158046 UNC8899 Degrader / Unkown
HY-158047 UNC8900 Degrader / Unkown
HY-158048 UNC9036 Degrader / Unkown
HY-158429 PROTAC CYP1B1 degrader-2 Degrader / Unkown
HY-158684 YX-02-030 Degrader / Unkown
HY-158685 RG7112D MDM2 Inhibitor / Unkown
HY-159175 XM-U-14 / Unkown
HY-159457 PROTAC SMARCA2/4-degrader-6 Degrader / Unkown
HY-160555 (S,R,S)-AHPC-CO-C9-NH2 / Unkown
HY-160555A (S,R,S)-AHPC-CO-C9-NH2 hydrochloride 98.79% Unkown
HY-160924 MS147 Inhibitor / Unkown
HY-161132 Lenalidomide 4'-alkyl-C5-azide / Unkown
HY-161194 (S,R,S)-AHPC-acetyl-azetidine-PIP-boc / Unkown
HY-161207 (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc / Unkown
HY-161367 VHL-SF2 / Unkown
HY-161368 BRD-SF2 Degrader / Unkown
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / Unkown
HY-162193 E3 Ligase Ligand-linker Conjugate 27 / Unkown
HY-162202 E3 Ligase Ligand-linker Conjugate 50 / Unkown
HY-162450 Antitumor agent-150 / Unkown
HY-162538 LC-MI-3 / Unkown
HY-162553 GNE7599 / Unkown
HY-162834 PROTAC SMARCA2/4-degrader-27 Degrader / Unkown
HY-162835 PROTAC SMARCA2/4-degrader-28 Degrader / Unkown
HY-162943 P60-L3-VHL / Unkown
HY-162947 2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid / Unkown
HY-163209 VH 032 amide-PEG6-amine hydrochloride / Unkown
HY-163215 (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc / Unkown
HY-163216 PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc / Unkown
HY-163217 PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc / Unkown
HY-163219 VHL Ligand 8-PEG2-O-piperidine-Boc / Unkown
HY-163220 (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc / Unkown
HY-163223 (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc / Unkown
HY-163224 (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc / Unkown
HY-163228 PROTAC PTK6 ligand-O-C2-O-piperidine-Boc / Unkown
HY-163231 (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH / Unkown
HY-163440 PROTAC NAMPT Degrader-1 Degrader / Unkown
HY-163845 YX862 Degrader / Unkown
HY-163872 PROTAC SMARCA2/4-degrader-10 Degrader / Unkown
HY-164977 JCS-1 Inhibitor / Unkown
HY-168026 CEP1347-VHL-02 / Unkown
HY-168027 CEP-1347-acid / Unkown
HY-168229 PROTAC SMARCA2 degrader-27 Degrader / Unkown
HY-168234 PROTAC SMARCA2 degrader-31 Inhibitor / Unkown
HY-169093 MS41 / Unkown
HY-169264 SJYHJ-026 / Unkown
HY-169395 (S,R,S)-AHPC-CO-PEG-C2-iodine / Unkown
HY-44630 VH 032 amide-alkylC6-acid / Unkown
HY-49515 SOS1 Ligand intermediate-2 / Unkown
HY-B2171 Carubicin Inducer / Unkown
HY-D2413 BODIPY FL VH032 / Unkown
HY-P5915 FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 Agonist / Unkown
HY-RS15648 VHL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W584525 VH032-NH-CO-CH2-NHBoc / Unkown
HY-W584527 VH032 analogue-1 / Unkown
HY-W584528 VH032 analogue-2 / Unkown
HY-W584529 VH032-C2-NH-Boc / Unkown
HY-W584530 VH032-C4-NH-Boc / Unkown
HY-W584531 VH032-C6-NH-Boc / Unkown
HY-W584532 VH032-O-C2-NH-Boc / Unkown
HY-W584533 VH032-PEG2-NH-BOC / Unkown
HY-W584534 VH032-CH2-Boc / Unkown
HY-W584535 VH032-C3-Boc / Unkown
HY-130845 AR antagonist 1 / Unkown
HY-131890 VH032 amide-PEG1-acid / Unkown
HY-135045 (S,R,S)-AHPC-C4-COOH / Unkown
HY-136186A (S,R,S)-AHPC-C7-amine dihydrochloride / Unkown
HY-139334 VH 101 phenol-alkylC6-amine dihydrochloride / Unkown
HY-139341 Pomalidomide 4'-alkylC3-azide / Unkown
HY-139343 Pomalidomide 4'-alkylC2-azide / Unkown
HY-162930 PROTAC METTL3 degrader 1 Degrader / Unkown
HY-164043 (S,R,S)-AHPC(Me)-amido-C2-acid / Unkown
HY-168288 MEK ligand-2 Inhibitor / Unkown
HY-168290 (S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide / Unkown
HY-400685 SMD-3040 intermediate-2 95.82% Unkown
HY-49514 SOS1 Ligand intermediate-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens VHL NCBI NCBI:7428