VHL - von Hippel-Lindau tumor suppressor Gene

Also Known as RCA1; VHL1; pVHL; HRCA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7428

About VHL

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,141,778-10,153,667 (from NCBI)

This gene has 6 transcripts (splice variants), 168 orthologues, 1 paralogue and is associated with 102 phenotypes. Ubiquitous expression in lymph node (RPKM 12.2), spleen (RPKM 10.0) and 25 other tissues.

Summary

This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many Other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]

VHL Products (3)

mRNA	Protein	Name
NM_000551.4	NP_000542.1	von Hippel-Lindau disease tumor suppressor isoform 1
NM_001354723.2	NP_001341652.1	von Hippel-Lindau disease tumor suppressor isoform 3
NM_198156.3	NP_937799.1	von Hippel-Lindau disease tumor suppressor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11641274	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11641274	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	10205047	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7660122	GOA
enables transcription elongation factor activity	IDA IDA: Inferred from direct assay	7660122	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	24899725	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid fibril formation	EXP EXP: Inferred from Experiment	34431623	GOA
involved in amyloid fibril formation	IDA IDA: Inferred from direct assay	34431623	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	34290272	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	30902965	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	23338840	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23338840	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23338840	GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	23338840	GOA
involved in negative regulation of signal transduction	EXP EXP: Inferred from Experiment	23338840	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11641274	GOA
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	7660122	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17973242	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34290272	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	24899725	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	12169691	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15824735	GOA
involved in regulation of cellular response to hypoxia	EXP EXP: Inferred from Experiment	10205047	GOA
involved in regulation of gene expression	EXP EXP: Inferred from Experiment	15824735	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	17973242	GOA
involved in regulation of gene expression	IEP IEP: Inferred from expression pattern	15824735	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34290272	GOA
is active in intracellular non-membrane-bounded organelle	EXP EXP: Inferred from Experiment	14963040	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VHL Protein Structure

VHL

0
100
200
213 a.a.

Protein Preferred Names	Protein Names
von Hippel-Lindau disease tumor suppressor	elongin binding protein

VHL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VHL	P40337	FN1	Homo sapiens	P02751	Anti Tag CoIP	18323857
Intra	VHL	P40337	RNF139	Homo sapiens	Q8WU17	Anti Bait CoIP	12032852
Cross	VHL	P40337	P0C6X7-PRO_0000037322	Human SARS coronavirus	P0C6X7-PRO_0000037322	Anti Tag CoIP	25732088
Cross	VHL	P40337	P0C6X7-PRO_0000037322	Human SARS coronavirus	P0C6X7-PRO_0000037322	Confocal	25732088
Cross	VHL	P40337	P0C6X7-PRO_0000037322	Human SARS coronavirus	P0C6X7-PRO_0000037322	Pull Down	25732088
Intra	VHL	P40337	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	17350623
Intra	VHL	P40337	PRKCZ	Homo sapiens	Q05513	Imaging	17350623
Intra	VHL	P40337	RACK1	Homo sapiens	P63244	Anti Tag CoIP	20871634
Intra	VHL	P40337	RACK1	Homo sapiens	P63244	Y2H	20871634
Intra	VHL	P40337	RACK1	Homo sapiens	P63244	Pull Down	20871634
Cross	VHL	P40337	Hif1a	Mus musculus	Q61221	Anti Bait CoIP	11292862
Cross	VHL	P40337	Hif1a	Mus musculus	Q61221	Far-WB	11292862
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	11292862
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	21602890
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Pull Down	11292862
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	34818544
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Bait CoIP	15601820
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	33961781
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	15601820
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Pull Down	25661653
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	18323857
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Bait CoIP	17353931
Intra	VHL	P40337	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	VHL	P40337	TGM2	Homo sapiens	P21980	Anti Bait CoIP	21625219
Intra	VHL	P40337	TGM2	Homo sapiens	P21980	Enzymatic Study	21625219
Intra	VHL	P40337	TGM2	Homo sapiens	P21980	Anti Tag CoIP	21625219
Intra	VHL	P40337	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VHL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76124	VHL Protein, Human (His)	P40337 (M1-D213)	≥ 90%, as determined by reducing SDS-PAGE.

VHL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80517	VHL Antibody (YA683)	IHC-P	Human
HY-P86001	VHL Antibody (YA5693)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Erythrocytosis, Familial, 2	Chuvash Polycythemia ECYT2 Familial Erythrocytosis 2 Autosomal Recessive Benign Erythrocytosis Polycythemia, Vhl-Dependent Chuvash Erythromatosis Chuvash Type Polycythemia Chuvash Erythrocytosis Von Hippel-Lindau-Dependent Polycythemia Polycythemia Chuvash Type Vhl-Dependent Polycythemia Erythrocytosis, Familial, Type 2
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Retinal Hemangioblastoma	Capillary Hemangioma Of Retina
Acute Biphenotypic Leukemia	Mixed Phenotype Acute Leukemia Acute Leukemia Of Ambiguous Lineage Acute Undifferentiated Leukemia Acute Leukemia Of Indeterminate Lineage Hybrid Acute Leukemia Mixed Lineage Acute Leukemia All With Myeloid Markers Aml With Lymphoid Markers Acute Leukemia Of Undetermined Lineage Bal Biphenotypic Acute Leukemia Undifferentiated Acute Leukemia Mpal Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 Leukemia, Biphenotypic, Acute
Myasthenic Syndrome, Congenital, 6, Presynaptic	Familial Infantile Myasthenia CMS6 Cmsea Congenital Myasthenic Syndrome 6 Familial Infantile Myasthenia Gravis 2 Fimg2 Myasthenic Syndrome, Congenital, Associated With Episodic Apnea Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea Congenital Myasthenic Syndrome Type Ia2, Formerly Cms1a2, Formerly Cms Ia2, Formerly Myasthenia, Familial Infantile, Formerly Fim, Formerly Myasthenia Gravis, Familial Infantile, 2, Formerly Fimg2, Formerly Cms Ia2 Cms1a2 Congenital Myasthenic Syndrome 6, Presynaptic Congenital Myasthenic Syndrome Type Ia2 Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea Fim Cms1a Cms-Ea Cms Ia Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea Congenital Myasthenic Syndrome Type 1a Congenital Myasthenic Syndrome Type Ia Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Hereditary Paraganglioma-Pheochromocytoma Syndromes	Hereditary Pheochromocytoma-Paraganglioma Hereditary Paraganglioma-Pheochromocytoma Familial Pheochromocytoma-Paraganglioma Paragangliomas 2 Paragangliomas 3 Paragangliomas 4 Sdhx-Related Paraganglioma-Pheochromocytoma Familial Paraganglioma Syndrome Familial Paraganglioma-Pheochromocytoma Syndromes Fpgl Fpgl/Pheo Paragangliomas 1 Paraganglioma
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Hemangioblastoma	Capillary Hemangioblastoma
Microcystic Adenoma	Adenoma Microcystic Adenoma, Microcystic
Sporadic Pheochromocytoma/Secreting Paraganglioma
Cystadenoma	Cystoma Craniopharyngioma
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Primary Polycythemia	Familial Erythrocytosis Familiar Polycythemia Benign Familial Polycythemia Congenital Erythrocytosis Familial Polycythemia Hereditary Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Familial Polycythemia Vera Primary Familial Polycythaemia Primary Inherited Polycythaemia
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Hemangioma Of Liver	Hepatic Hemangioma Angioma Of Liver Hepatic Angioma
Collecting Duct Carcinoma	Kidney Medullary Carcinoma Renal Medullary Carcinoma Bdc Bellini Carcinoma Bellini Duct Carcinoma Cdc Collecting Duct Carcinoma Of The Kidney Renal Cell Adenocarcinoma Carcinoma Of Renal Collecting Duct Renal Carcinoma, Collecting Duct Type Renal Cell Carcinoma Bellini'S Duct Carcinoma Renal Collecting Duct Carcinoma Adenocarcinoma Of Kidney
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Hepatoblastoma
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Multiple Endocrine Neoplasia, Type Iia	Multiple Endocrine Neoplasia Type 2a Sipple Syndrome Multiple Endocrine Neoplasia Type 2 MEN2A Men2 Ptc Syndrome Multiple Endocrine Neoplasia, Type 2 Multiple Endocrine Neoplasia Iia Men 2a Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia, Type 2a Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Ii Men2 Syndrome Men-2a Syndrome Multiple Neoplasia 2a Multiple Neoplasia Type 2
Leiomyomatosis
Fumarate Hydratase Deficiency	Fumarase Deficiency Fumaric Aciduria
Pancreatic Serous Cystadenoma
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Central Nervous System Hemangioma	Hemangioma Of Cns Hemangioma Of The Central Nervous System
Cardiovascular Organ Benign Neoplasm
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Hemangioma	Hemangiomas
Middle Ear Adenocarcinoma	Adenocarcinoma Of Middle Ear Adenocarcinoma Of The Middle Ear
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Hereditary Renal Cell Carcinoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-180970	TD-004	Degrader	/	Phase 3
HY-130604	DT2216		99.97%	Phase 2
HY-159607	PRT3789	Degrader	98.08%	Phase 2
HY-156730	KT-333	Degrader	98.91%	Phase 1
HY-162362	MS8709	Degrader	99.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (467)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100947	VH-298	Inhibitor	99.78%	Unkown
HY-111431	p-Cresyl sulfate		99.98%	Unkown
HY-120217	VH032		99.43%	Unkown
HY-111997	VH285-PEG4-C4-Cl		≥98.0%	Unkown
HY-113491	3-Phosphoglyceric acid	Chemical	99.88%	Unkown
HY-130708	UNC6852	Inhibitor	98.49%	Unkown
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-129937A	GNE-987	Inhibitor	99.98%	Unkown
HY-151623	ACBI2	Inhibitor	99.38%	Unkown
HY-101763A	(S,R,S)-AHPC monohydrochloride		99.83%	Unkown
HY-112078	(S,R,S)-AHPC-Me		99.96%	Unkown
HY-18728	STF-31		99.79%	Unkown
HY-148030	XL01126		98.90%	Unkown
HY-145514A	dTAGV-1-NEG	Control	99.73%	Unkown
HY-130492	ARCC-4	Inhibitor	99.88%	Unkown
HY-132296	GSK215	Inhibitor	99.26%	Unkown
HY-160415A	WD6305 TFA		99.81%	Unkown
HY-152154	PROTAC NAMPT Degrader-30	Degrader	99.41%	Unkown
HY-137516	LC-2	Inhibitor	98.48%	Unkown
HY-114322	VZ185	Inhibitor	99.95%	Unkown
HY-162250	MS8847	Inhibitor	99.78%	Unkown
HY-153863	MS934	Degrader	98.48%	Unkown
HY-42424	(S,R,S)-AHPC-Me hydrochloride		99.95%	Unkown
HY-161176	PROTAC KRAS G12D degrader 1		98.32%	Unkown
HY-160525	NVS-VHL720	Degrader	98.63%	Unkown
HY-163897	PROTAC NCOA4 degrader-1	Inhibitor	99.75%	Unkown
HY-148771	MTX-23		99.79%	Unkown
HY-156106	VHL-IN-1		99.84%	Unkown
HY-145479	PROTAC AR-V7 degrader-1	Degrader	98.19%	Unkown
HY-103598	(S,R,S)-AHPC-PEG3-N3		99.67%	Unkown
HY-103602	(S,R,S)-AHPC-PEG3-NH2 hydrochloride		99.01%	Unkown
HY-176786	MCB-36		98.43%	Unkown
HY-145816A	JPS016 TFA		99.47%	Unkown
HY-153188	JNJ-1013		99.97%	Unkown
HY-169093	MS41		98.97%	Unkown
HY-168016	PROTAC YAP degrader-1		99.77%	Unkown
HY-136262	CRBN-6-5-5-VHL	Degrader	99.45%	Unkown
HY-103601	(S,R,S)-AHPC-PEG4-N3		99.71%	Unkown
HY-139218	(S,R,S)-AHPC-Me-C6-NH2		99.81%	Unkown
HY-159779	NR-V04	Degrader	99.90%	Unkown
HY-44432	Navitoclax-piperazine	Inhibitor	99.73%	Unkown
HY-141438	SIM1	Degrader	99.47%	Unkown
HY-155994	PIK5-12d		99.15%	Unkown
HY-125878	PROTAC SGK3 degrader-1	Inhibitor	99.89%	Unkown
HY-130602	MS432	Degrader	99.72%	Unkown
HY-125834	GMB-475		98.69%	Unkown
HY-125905	VH032-cyclopropane-F		99.92%	Unkown
HY-130257	CP5V		99.31%	Unkown
HY-155815	MS9715		99.48%	Unkown
HY-130979	EED226-COOH	Degrader	99.88%	Unkown
HY-47070	VH 101, acid		98.82%	Unkown
HY-114402	ARD-69	Degrader	99.61%	Unkown
HY-100746	STF-62247	Inducer	98.69%	Unkown
HY-103599	(S,R,S)-AHPC-PEG2-N3		99.94%	Unkown
HY-130815A	MAK683-C2-acid hydrochloride	Inhibitor	99.60%	Unkown
HY-131865	SJF-1521	Degrader	99.65%	Unkown
HY-103604A	(S,R,S)-AHPC-PEG4-NH2		99.51%	Unkown
HY-128756	SIAIS178	Inhibitor	98.64%	Unkown
HY-156744	DBr-1	Degrader	98.87%	Unkown
HY-103603	(S,R,S)-AHPC-PEG2-NH2 hydrochloride		99.77%	Unkown
HY-123961	SJF-8240	Degrader	99.33%	Unkown
HY-125845A	(S,S,S)-AHPC hydrochloride		99.16%	Unkown
HY-126456	(S,R,S)-AHPC-propargyl		99.46%	Unkown
HY-149924	CST626		99.60%	Unkown
HY-123109	(S,R,S)-AHPC-Boc		96.36%	Unkown
HY-103600	(S,R,S)-AHPC-PEG1-N3		98.78%	Unkown
HY-145815A	JPS014 TFA	Inducer	98.12%	Unkown
HY-147099	dTAG-47-NEG	Control	97.8%	Unkown
HY-153119	TMX-4153	Degrader	98.96%	Unkown
HY-153598	LD4172		98.32%	Unkown
HY-157581	MS39	Degrader	99.89%	Unkown
HY-111905	BRD7-IN-1	Inhibitor	99.77%	Unkown
HY-128767	VH032-PEG3-acetylene		98.10%	Unkown
HY-128845	PROTAC CRBN Degrader-1	Degrader	98.77%	Unkown
HY-130271	(S,R,S)-AHPC-PEG5-COOH		99.79%	Unkown
HY-156152A	PROTAC CARM1 degrader-1 hydrochloride	Degrader	99.94%	Unkown
HY-160924	MS147	Degrader	98.31%	Unkown
HY-162943	P60-L3-VHL		99.84%	Unkown
HY-171658	R1-ICR-5		98.73%	Unkown
HY-42419	(S,R,S)-AHPC-Me-NHBoc		98.26%	Unkown
HY-133487B	(S,R,S)-AHPC-C8-NH2		97.04%	Unkown
HY-130714	TD-165		98.08%	Unkown
HY-132857A	ZXH-4-130 TFA		99.71%	Unkown
HY-180907	PROTAC USP39 Degrader-1		98.61%	Unkown
HY-158239	MS181		98.36%	Unkown
HY-111663	VL285		99.34%	Unkown
HY-145703	SHP2-D26 isomer-1	Control	98.52%	Unkown
HY-148671	(S,R,S)-AHPC-amido-C7-acid		98.71%	Unkown
HY-171140	PROTAC HDAC6 degrader 3	Degrader	99.81%	Unkown
HY-173011	RJS308		99.62%	Unkown
HY-173011A	RJS308 TFA		99.00%	Unkown
HY-42424A	(S,R,S)-AHPC-Me dihydrochloride		99.84%	Unkown
HY-103604	(S,R,S)-AHPC-PEG4-NH2 hydrochloride		98.17%	Unkown
HY-103605	(S,R,S)-AHPC-C6-PEG3-C4-Cl		97.01%	Unkown
HY-135045	(S,R,S)-AHPC-C4-COOH		95.92%	Unkown
HY-136006B	(S,R,S)-AHPC-C6-NH2		98.03%	Unkown
HY-158684	YX-02-030		99.86%	Unkown
HY-161410	WH244	Degrader	99.82%	Unkown
HY-170859	AH078	Inhibitor	99.73%	Unkown
HY-159147	SIAIS039		99.68%	Unkown
HY-171830	MS105		98.27%	Unkown
HY-112495	VH032-PEG5-C6-Cl		99.93%	Unkown
HY-123109A	(S,S,S)-AHPC-Boc	Control	97.21%	Unkown
HY-131388	ABM-14		98.10%	Unkown
HY-133045	VHL Ligand 8		98.04%	Unkown
HY-135312	AZ'6421	Inhibitor	98.13%	Unkown
HY-143275	HL-8	Inhibitor	99.17%	Unkown
HY-158345	PROTAC ATM degrader-1		98.01%	Unkown
HY-175252	PROTAC EGFR degrader 14		99.26%	Unkown
HY-B2171A	Carubicin hydrochloride	Inducer	98.33%	Unkown
HY-133737	GAL-02-221	Inhibitor	99.87%	Unkown
HY-103603A	(S,R,S)-AHPC-PEG2-NH2		98.06%	Unkown
HY-130711B	(S,R,S)-AHPC-C3-NH2 hydrochloride		96.68%	Unkown
HY-130845A	AR antagonist 1 hydrochloride	Antagonist	99.53%	Unkown
HY-145819	JPS036		99.31%	Unkown
HY-148880	VHLL-BCN		96.30%	Unkown
HY-150803	VHL Ligand 14		99.93%	Unkown
HY-176792	ACBI-4	Degrader	98.01%	Unkown
HY-111431AR	p-Cresyl sulfate potassium (Standard)		99.88%	Unkown
HY-163167	VH 032 amide-alkylC5-azide		98.32%	Unkown
HY-130991	K-Ras ligand-Linker Conjugate 6		/	Unkown
HY-145264	OARV-771	Inhibitor	98.77%	Unkown
HY-131387	(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2		96.12%	Unkown
HY-136183	(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride		96.35%	Unkown
HY-136184	(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride		96.33%	Unkown
HY-103606	(S,R,S)-AHPC-PEG6-C4-Cl		95.97%	Unkown
HY-122702	PEG6-(CH2CO2H)2		95.0%	Unkown
HY-130654	(S,R,S)-AHPC-C2-PEG4-N3		97.63%	Unkown
HY-130716	Thalidomide-NH-C10-COOH	Inducer	97.50%	Unkown
HY-136005	VH032-C7-COOH		99.92%	Unkown
HY-138678	(R,S,S)-VH032		98.99%	Unkown
HY-148896	(S,R,S)-AHPC-C2-PEG3-BCN		98.44%	Unkown
HY-149760	PVD-06	Inhibitor	98.30%	Unkown
HY-155356	YN14	Degrader	99.08%	Unkown
HY-162553	GNE7599		99.19%	Unkown
HY-176528	PROTAC ERK5 degrader-1	Inhibitor	99.58%	Unkown
HY-D2413	BODIPY FL VH032		94.34%	Unkown
HY-W128709	SNAP-fusion protein ligand-1	Ligand	96.03%	Unkown
HY-138635	PROTAC BRD4 Degrader linker conjugate-3	Inhibitor	98.54%	Unkown
HY-136163	(S,R,S)-AHPC-C2-NH2 dihydrochloride		98.63%	Unkown
HY-136164	VH032-OH		99.43%	Unkown
HY-100947A	cis VH-298		99.96%	Unkown
HY-103607	(S,R,S)-AHPC-PEG2-C4-Cl		98.12%	Unkown
HY-103608	(S,R,S)-AHPC-(C3-PEG)2-C6-Cl		98.85%	Unkown
HY-107425A	cis-MZ 1		99.8%	Unkown
HY-131866	(S,R,S)-CO-C2-acid		98.0%	Unkown
HY-132857	ZXH-4-130		99.70%	Unkown
HY-136008	(S,R,S)-AHPC-PEG1-NH2		98.48%	Unkown
HY-136187A	(S,R,S)-AHPC-C5-NH2 dihydrochloride		97.8%	Unkown
HY-141797	MS33		99.38%	Unkown
HY-147174	PROTAC_ERRα	Degrader	99.71%	Unkown
HY-172946	SD-2301	Degrader	/	Unkown
HY-174981	LC-MF-4		98.05%	Unkown
HY-175417	VHL-SNAP2-5C		/	Unkown
HY-178065	PROTAC G9a/GLP degrader 1	Degrader	98.22%	Unkown
HY-P11228	FPP29		99.20%	Unkown
HY-130845	AR antagonist 1	Antagonist	99.03%	Unkown
HY-47851	VH 101, thiol		98.66%	Unkown
HY-130815	MAK683-CH2CH2COOH	Inhibitor	/	Unkown
HY-131959	(S,R,S)-AHPC-PEG5-Boc		/	Unkown
HY-133487A	(S,R,S)-AHPC-C8-NH2 hydrochloride		/	Unkown
HY-136006A	(S,R,S)-AHPC-C6-NH2 hydrochloride		/	Unkown
HY-136055	(S,R,S)-AHPC-C5-COOH	Inhibitor	98.81%	Unkown
HY-136165	(S,R,S)-AHPC-PEG3-propionic acid		97.03%	Unkown
HY-148381	A947		/	Unkown
HY-156730A	KT-333 ammonium	Degrader	99.48%	Unkown
HY-103602A	(S,R,S)-AHPC-PEG3-NH2		99.26%	Unkown
HY-103603B	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride		≥95.0%	Unkown
HY-114176B	(S,R,S)-AHPC-C4-NH2 dihydrochloride		/	Unkown
HY-129941A	(S,R,S)-AHPC-C10-NH2 dihydrochloride		96.74%	Unkown
HY-130642	(S,R,S)-AHPC-Me-C10-Br		98.02%	Unkown
HY-130707	K-Ras ligand-Linker Conjugate 3		/	Unkown
HY-130798	(S,R,S)-AHPC-amido-C5-acid		99.58%	Unkown
HY-130816	(S,R,S)-AHPC-O-Ph-PEG1-NH2		96.97%	Unkown
HY-130823	K-Ras ligand-Linker Conjugate 5		99.79%	Unkown
HY-130849	(S,R,S)-AHPC-Me-C5-COOH		96.87%	Unkown
HY-138632	PROTAC BRD4 Degrader linker conjugate-1	Degrader	98.98%	Unkown
HY-44148	FAK ligand-Linker Conjugate 1		98.91%	Unkown
HY-107425B	cis-MZ 1 hydrate		99.0%	Unkown
HY-111823	VH032 thiol		95.91%	Unkown
HY-114176	(S,R,S)-AHPC-C4-NH2 hydrochloride		99.69%	Unkown
HY-131168	(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH		98.57%	Unkown
HY-131295	PD0325901-O-C2-dioxolane	Inhibitor	98.62%	Unkown
HY-136257	CMP98		99.72%	Unkown
HY-138550A	(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA		99.63%	Unkown
HY-138861A	(S,R,S)-AHPC-C1-NH2 hydrochloride		98.08%	Unkown
HY-138862	(S,R,S)-AHPC-C1-Br		98.0%	Unkown
HY-143883	MS143	Degrader	97.8%	Unkown
HY-151227	VL285 Phenol		98.56%	Unkown
HY-156568A	SMD-3040 TFA	Degrader	99.90%	Unkown
HY-157512	SJF-0661		99.2%	Unkown
HY-159798	NR-11c	Inhibitor	99.75%	Unkown
HY-162930	PROTAC METTL3 degrader 1	Degrader	/	Unkown
HY-162947	2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid		99.75%	Unkown
HY-164977	JCS-1	Inhibitor	99.38%	Unkown
HY-172767	STAT3-D11-PROTAC-VHL		96.33%	Unkown
HY-173561	MS115	Inhibitor	/	Unkown
HY-174873	AF151		98.87%	Unkown
HY-175885	PROTAC FTO degrader 1		/	Unkown
HY-177119	ZBP1 Covalent PROTAC-1	Inhibitor	96.87%	Unkown
HY-181789	DOT1L808	Degrader	98.30%	Unkown
HY-181955	MS1129		/	Unkown
HY-184524	PROTAC HDAC4 Degrader-2	Control	/	Unkown
HY-185142	(S,R,S)-AHPC-Me-C8-NHS ester		99.89%	Unkown
HY-139341	Pomalidomide 4'-alkylC3-azide		/	Unkown
HY-RS16509	Vhl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W998310	(S,R,S)-AHPC-Me-CO-C4-COOH		99.75%	Unkown
HY-W998311	(S,R,S)-AHPC-Me-CO-C6-COOH		95.0%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-111905A	BRD7-IN-1 free base	Inhibitor	/	Unkown
HY-129775	K-Ras ligand-Linker Conjugate 1		/	Unkown
HY-129776	K-Ras ligand-Linker Conjugate 2		/	Unkown
HY-129941	(S,R,S)-AHPC-C10-NH2		/	Unkown
HY-130711A	(S,R,S)-AHPC-C3-NH2 TFA		/	Unkown
HY-133487	(S,R,S)-AHPC-C8-NH2 dihydrochloride		/	Unkown
HY-136006	(S,R,S)-AHPC-C6-NH2 dihydrochloride		/	Unkown
HY-141486	(Rac)-PROTAC PARP/EGFR ligand 1		/	Unkown
HY-170824	SMD-3236	Degrader	/	Unkown
HY-182766	AMX-883	Degrader	/	Unkown
HY-114176A	(S,R,S)-AHPC-C4-NH2		/	Unkown
HY-125846	(S,R,S)-AHPC-PEG1-OTs		/	Unkown
HY-125906	VHL Ligand-Linker Conjugates 15		/	Unkown
HY-130711	(S,R,S)-AHPC-C3-NH2		/	Unkown
HY-130822	K-Ras ligand-Linker Conjugate 4		98.76%	Unkown
HY-130847	(S,R,S)-AHPC-Me-C10-NH2		96.19%	Unkown
HY-136008A	(S,R,S)-AHPC-PEG1-NH2 dihydrochloride		/	Unkown
HY-156730B	KT-333 diammonium	Degrader	/	Unkown
HY-184958	AKT ligand-3	Ligand	/	Unkown
HY-184972	E3 Ligase Ligand-linker Conjugate 238		/	Unkown
HY-184990	E3 Ligase Ligand-linker Conjugate 239		/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-103602B	(S,R,S)-AHPC-PEG3-NH2 dihydrochloride		/	Unkown
HY-103603C	(S,S,S)-AHPC-PEG2-NH2		/	Unkown
HY-111824	VH032-thiol-C6-NH2		/	Unkown
HY-112078A	(S,R,S,R)-AHPC-Me		/	Unkown
HY-112078C	(S,R,R,R)-AHPC-Me		/	Unkown
HY-120217A	(S,S,S)-VH032		/	Unkown
HY-130641	Br-C10-methyl ester		97.87%	Unkown
HY-130711C	(S,R,S)-AHPC-C3-NH2 dihydrochloride		/	Unkown
HY-130991A	K-Ras ligand-Linker Conjugate 6 formate		98.93%	Unkown
HY-132862	ZXH-4-137		/	Unkown
HY-132997	PROTAC Bcl-xL degrader-3	Inhibitor	/	Unkown
HY-133046	VHL Ligand-Linker Conjugates 17		/	Unkown
HY-134303	CST651	Degrader	/	Unkown
HY-136163A	(S,R,S)-AHPC-C2-NH2		/	Unkown
HY-136186	(S,R,S)-AHPC-C7-amine		/	Unkown
HY-136186B	(S,R,S)-AHPC-C7-amine hydrochloride		/	Unkown
HY-136187	(S,R,S)-AHPC-C5-NH2		/	Unkown
HY-137516A	LC-2 epimer	Degrader	/	Unkown
HY-138637	PROTAC BRD4 Degrader-14	Inhibitor	/	Unkown
HY-138678B	(S,R,R)-VH032		/	Unkown
HY-138861	(S,R,S)-AHPC-C1-NH2		/	Unkown
HY-139335	VH 101 phenol-alkylC4-amine dihydrochloride		/	Unkown
HY-141651	(S,R,S)-AHPC-C3-COOH		/	Unkown
HY-144323	YF135		/	Unkown
HY-144605	PROTAC EGFR degrader 3	Inhibitor	97.39%	Unkown
HY-145514B	dTAGV-1-NEG TFA	Control	/	Unkown
HY-145715	Azido-PEG2-VHL		/	Unkown
HY-145815	JPS014	Inducer	/	Unkown
HY-145816	JPS016		/	Unkown
HY-145818	JPS035	Degrader	/	Unkown
HY-146022	SIAIS117	Degrader	/	Unkown
HY-147235	PROTAC RIPK2 Degrader-1	Inhibitor	/	Unkown
HY-147373	DA-PROTAC		/	Unkown
HY-148406	(S,R,S)-AHPC-C10-NHBoc		98.32%	Unkown
HY-150400	XF056-132 free base	Degrader	/	Unkown
HY-150400A	XF056-132	Degrader	/	Unkown
HY-150812	VHL Ligand 23		/	Unkown
HY-153321A	(R,R)-Bexobrutideg	Degrader	98.83%	Unkown
HY-153425	PROTAC SMARCA2/4 degrader-41	Degrader	/	Unkown
HY-153820	PROTAC BRD4 Degrader-20	Degrader	/	Unkown
HY-155356A	YN14 (mixture of diastereomers)		/	Unkown
HY-155506	NAMPT degrader-3	Degrader	/	Unkown
HY-155643	PROTAC TG2 degrader-1	Inhibitor	/	Unkown
HY-156152	PROTAC CARM1 degrader-1	Inhibitor	/	Unkown
HY-156153	PROTAC CARM1 degrader-2	Inhibitor	/	Unkown
HY-156401	BRD9 Degrader-1	Degrader	/	Unkown
HY-157558	KDRLKZ-1	Ligand	/	Unkown
HY-157590	E3 ligase Ligand-Linker Conjugate 32		/	Unkown
HY-157593	E3 ligase Ligand-Linker Conjugate 35		/	Unkown
HY-157596	E3 ligase Ligand-Linker Conjugate 40		/	Unkown
HY-157597	E3 ligase Ligand-Linker Conjugate 42		/	Unkown
HY-157598	E3 ligase Ligand-Linker Conjugate 46		/	Unkown
HY-157634	E3 Ligase Ligand-linker Conjugate 91		/	Unkown
HY-157752	E3 Ligase Ligand-linker Conjugate 101		/	Unkown
HY-157753	E3 Ligase Ligand-linker Conjugate 102		/	Unkown
HY-157754	E3 Ligase Ligand-linker Conjugate 103		/	Unkown
HY-157804	PROTAC SARS-CoV-2 Mpro degrader-1		/	Unkown
HY-157805	PROTAC SARS-CoV-2 Mpro degrader-2		/	Unkown
HY-158036	PROTAC STING Degrader-2		/	Unkown
HY-158046	UNC8899	Degrader	/	Unkown
HY-158047	UNC8900	Degrader	/	Unkown
HY-158048	UNC9036		/	Unkown
HY-158429	PROTAC CYP1B1 degrader-2		/	Unkown
HY-158685	RG7112D	MDM2 Inhibitor	/	Unkown
HY-159175	XM-U-14		/	Unkown
HY-160423	MS8815N	Control	/	Unkown
HY-160555	(S,R,S)-AHPC-CO-C9-NH2		/	Unkown
HY-160555A	(S,R,S)-AHPC-CO-C9-NH2 hydrochloride		98.79%	Unkown
HY-161132	Lenalidomide 4'-alkyl-C5-azide		/	Unkown
HY-161194	(S,R,S)-AHPC-acetyl-azetidine-PIP-boc		/	Unkown
HY-161207	(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc		/	Unkown
HY-161367	VHL-SF2		/	Unkown
HY-161368	BRD-SF2	Degrader	/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162193	E3 Ligase Ligand-linker Conjugate 27		/	Unkown
HY-162202	E3 Ligase Ligand-linker Conjugate 50		/	Unkown
HY-162281	PROTAC SOS1 degrader-6		/	Unkown
HY-162450	Antitumor agent-150		/	Unkown
HY-162813	PROTAC SMARCA2/4 degrader-25		/	Unkown
HY-162834	PROTAC SMARCA2/4 degrader-27	Degrader	/	Unkown
HY-162835	PROTAC SMARCA2/4 degrader-28	Degrader	/	Unkown
HY-163209	VH 032 amide-PEG6-amine hydrochloride		/	Unkown
HY-163215	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163216	PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163217	PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc		/	Unkown
HY-163219	VHL Ligand 8-PEG2-O-piperidine-Boc		/	Unkown
HY-163220	(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc		/	Unkown
HY-163223	(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc		/	Unkown
HY-163224	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163228	PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163231	(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH		/	Unkown
HY-163440	PROTAC NAMPT Degrader-1	Degrader	/	Unkown
HY-168026	CEP1347-VHL-02		/	Unkown
HY-168027	CEP-1347-acid		/	Unkown
HY-168234	PROTAC SMARCA2 degrader-31	Inhibitor	/	Unkown
HY-168288	MEK ligand-2	Inhibitor	/	Unkown
HY-168453	dBAZ2B	Degrader	/	Unkown
HY-168454	trans-VH032-Cyclopropane-F-C-cyclohexane-p-C-OTs		/	Unkown
HY-168487	PROTAC WDR5 degrader 1	Inhibitor	/	Unkown
HY-169086	KL-465		/	Unkown
HY-169395	(S,R,S)-AHPC-CO-PEG-C2-iodine		/	Unkown
HY-170352	E3 Ligase Ligand-linker Conjugate 150		/	Unkown
HY-170390	AB3067	Degrader	/	Unkown
HY-170769	FLT3 Ligand-Linker Conjugate 1	Inhibitor	/	Unkown
HY-170859A	AH081	Inhibitor	/	Unkown
HY-170996	ROR1 ligand-1	Degrader	/	Unkown
HY-172625	VH 101-amide-piperidine-Pip-alkyne		/	Unkown
HY-172645	(S,R,S)-AHPC-Me-amide-C-O-C5-Br		/	Unkown
HY-172948	VHL Ligand 36		/	Unkown
HY-173010	Me-(S,R,S)-AHPC-CO-C5-N3		/	Unkown
HY-173433	JV8	Degrader	/	Unkown
HY-174445	C199		/	Unkown
HY-174858	dASK1-VHL		/	Unkown
HY-174860	ASK1 ligand 1	Degrader	/	Unkown
HY-174861	(S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH		/	Unkown
HY-174875	(S,R,S)-AHPC-CO-C2-phenylboronic acid		/	Unkown
HY-174920	PROTAC BRD4 Degrader-34	Inhibitor	/	Unkown
HY-175025	CH091138		/	Unkown
HY-175144	KRASG12D-IN-6	Inhibitor	/	Unkown
HY-175255	EGFR-IN-47-C6-COOMe		/	Unkown
HY-175273	MA191		/	Unkown
HY-175358	PROTAC USP7 Degrader-1	Degrader	/	Unkown
HY-175797	E3 ligase Ligand 82		/	Unkown
HY-176261	DDD2		/	Unkown
HY-176366	AHPC-PEG6-CH2COOH		/	Unkown
HY-176492	E3 Ligase Ligand-linker Conjugate 193	Chemical	/	Unkown
HY-176530	(S,R,S)-AHPC-Me-amide-C4-Br		/	Unkown
HY-176823	PROTAC SGK3 degrader-2	Degrader	/	Unkown
HY-176917	E3 ligase Ligand 76		/	Unkown
HY-178467	PROTAC FAK degrader 4	Degrader	/	Unkown
HY-179230	E3 Ligase Ligand-linker Conjugate 214		/	Unkown
HY-179424	PROTAC HIF-1α degrader-2		/	Unkown
HY-179435	(S,R,S)-AHPC-Bromooctanoic acid	Ligand	/	Unkown
HY-179576	CV2a		/	Unkown
HY-179582	PROTAC DNPH1 Degrader 1	Degrader	/	Unkown
HY-181134	PROTAC HMGCR Degrader-2		/	Unkown
HY-181287	PROTAC CCR9 Degrader 1		/	Unkown
HY-181289	SelDeg51		/	Unkown
HY-181306	PROTAC EZH2 Degrader-11	Degrader	/	Unkown
HY-181326	PROTAC EZH2 Degrader-25		/	Unkown
HY-181355	PROTAC EZH2 Degrader-28	Degrader	/	Unkown
HY-181412	PROTAC EZH2 Degrader-43		/	Unkown
HY-181414	PROTAC EZH2 Degrader-45	Degrader	/	Unkown
HY-181728	MS243	Degrader	/	Unkown
HY-181734	E3 Ligase Ligand-linker Conjugate 224		/	Unkown
HY-181737	E3 Ligase Ligand-linker Conjugate 225		/	Unkown
HY-181748	VHL Ligand-Linker Conjugates 18		/	Unkown
HY-181787	DOT1L705	Inhibitor	/	Unkown
HY-181790	DOT1L ligand-2	Ligand	/	Unkown
HY-181791	VHL Ligand 39		/	Unkown
HY-181869	PROTAC BET Degrader-17		/	Unkown
HY-181880	PROTAC NAMPT Degrader-28	Degrader	/	Unkown
HY-181882	MV78-OH-C7-COOH		/	Unkown
HY-181905	(S,R,S)-AHPC-Me-C2-piperazine		/	Unkown
HY-181906	ZnPc-PEG2-VH032		/	Unkown
HY-181909	PROTAC SMARCA2 degrader-36	Degrader	/	Unkown
HY-181949	PROTAC BRD9 Degrader-10		/	Unkown
HY-181951	PROTAC BRD9 Degrader-11	Degrader	/	Unkown
HY-183007	LJM133	Degrader	/	Unkown
HY-183070	CXJ2080		/	Unkown
HY-183073	TZ1104		/	Unkown
HY-183555	MS108	Degrader	/	Unkown
HY-183799	GSI526		/	Unkown
HY-183800	JH-l-25-NH2	Ligand	/	Unkown
HY-183939	L1-CIDE-BRM1-13		/	Unkown
HY-184497	PROTAC EGFR degrader 18		/	Unkown
HY-184498	E3 Ligase Ligand-linker Conjugate 236		/	Unkown
HY-184506	R4VPL3-1	Inhibitor	/	Unkown
HY-184507	(R,R,R)-AHPC		/	Unkown
HY-184508	E3 ligase Ligand 81		/	Unkown
HY-184560	VL285-PEG3-I		/	Unkown
HY-184594	WDR5 ligand 4		/	Unkown
HY-184670	VHL Ligand 41		/	Unkown
HY-184671	VHL Ligand 41-CO-C10-NH2		/	Unkown
HY-184855	(S,S,S,S)-AHPC-Me		/	Unkown
HY-185582	EZH2 ligand-4		/	Unkown
HY-186146	SGI-1776-VHL-02		96.67%	Unkown
HY-186146A	SGI-1776-VHL-02-epimer	Control	/	Unkown
HY-186147	SGI-1776-amide-C6-acid		/	Unkown
HY-186225	KV-14		/	Unkown
HY-186226	KVL-9	Ligand	/	Unkown
HY-187006	Nampt-IN-21	Inhibitor	/	Unkown
HY-187072	(S,R,R)-VH032-CO-PEG4-NH2		/	Unkown
HY-400685	SMD-3040 intermediate-2		95.82%	Unkown
HY-44630	VH 032 amide-alkylC6-acid		/	Unkown
HY-48682	AKT ligand-2	Inhibitor	/	Unkown
HY-49515	VHL Ligand intermediate-2	Inhibitor	/	Unkown
HY-B2171	Carubicin	Inducer	95.82%	Unkown
HY-P11493	ALAPYIP		/	Unkown
HY-P5915	FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2	Agonist	/	Unkown
HY-RS15648	VHL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W584525	VH032-NH-CO-CH2-NHBoc		/	Unkown
HY-W584527	VH032 analogue-1		/	Unkown
HY-W584528	VH032 analogue-2		/	Unkown
HY-W584529	VH032-C2-NH-Boc		/	Unkown
HY-W584530	VH032-C4-NH-Boc		/	Unkown
HY-W584531	VH032-C6-NH-Boc		/	Unkown
HY-W584532	VH032-O-C2-NH-Boc		/	Unkown
HY-W584533	VH032-PEG2-NH-BOC		/	Unkown
HY-W584534	VH032-CH2-Boc		/	Unkown
HY-W584535	VH032-C3-Boc		/	Unkown
HY-103599R	(S,R,S)-AHPC-PEG2-N3 (Standard)		/	Unkown
HY-117844	VHL Ligand 35		/	Unkown
HY-122570	VHL Ligand 38	Inhibitor	/	Unkown
HY-125845B	(S,S,S)-AHPC		/	Unkown
HY-136186A	(S,R,S)-AHPC-C7-amine dihydrochloride		/	Unkown
HY-139334	VH 101 phenol-alkylC6-amine dihydrochloride		/	Unkown
HY-139343	Pomalidomide 4'-alkylC2-azide		/	Unkown
HY-164043	(S,R,S)-AHPC(Me)-amido-C2-acid		95.05%	Unkown
HY-168290	(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide		/	Unkown
HY-174856	PROTAC HBeAg degrader-1	Degrader	/	Unkown
HY-181356	(S,R,S,R)-AHPC-Me-CO-C7-N3		/	Unkown
HY-403544	CbzNH-(C5-O)2-C4-Boc		/	Unkown
HY-49514	VHL Ligand intermediate-1	Inhibitor	/	Unkown
HY-RS22941	Vhl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W1130360	(S,R,S)-AHPC-Me-PEG3-azide		/	Unkown
HY-W1130361	(S,R,S)-AHPC-PEG5-Azide		/	Unkown
HY-W1130374	(S,R,S)-AHPC-amide-C10-azide		/	Unkown
HY-W1130395	(S,R,S)-AHPC-PEG2-SH		/	Unkown
HY-W590558	(S,R,S)-AHPC-PEG8-NH2		/	Unkown
HY-W598206	(S,R,S)-AHPC-PEG8-NH2 hydrochloride		/	Unkown
HY-W688682	(S,R,S)-AHPC-C5-NH2 hydrochloride		/	Unkown
HY-W800760	(S,R,S)-AHPC-PEG6-Tos		/	Unkown
HY-W800964	(S,R,S)-AHPC 2-OH hydrochloride		/	Unkown
HY-W926049	(S,R,S)-AHPC-Me-C4-NH2 hydrochloride		/	Unkown
HY-W937057	(S,R,S)-AHPC-Me-10-bromodecanoic acid		/	Unkown
HY-W998245	(R,R,R)-AHPC hydrochloride		/	Unkown
HY-W998246	(R,R,S)-AHPC		/	Unkown
HY-W998247	(S,R,R)-VH032 hydrochloride		/	Unkown
HY-W998296	(S,R,S)-AHPC-PEG6-C4-NH2 hydrochloride		/	Unkown
HY-W998297	(S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride		/	Unkown
HY-W998298	(S,R,S)-AHPC-C5-PEG3-C3		/	Unkown
HY-W998314	(S,R,S)-AHPC-Me-CO-C2-COOH		/	Unkown
HY-W998315	(S,R,S)-AHPC-Me-CO-C3-COOH		/	Unkown
HY-W998339	(R,S,R)-AHPC-NHBoc		/	Unkown
HY-W999557	(R,S,S)-VH032-PEG5-N3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VHL	VGNC	VGNC:97325
Rattus norvegicus	VHL	RGD	RGD:3960
Mus musculus	VHL	MGD	MGI:103223
Others	VHL	NCBI