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Disulfide Stress and Cardiovascular Diseases

Oxidative Stress Proteostasis Unfolded Protein Response Cellular Stress

Disulfide stress is a specialized redox imbalance in which cellular thiol-control systems fail and abnormal disulfide bonds or oxidized cysteine species accumulate. It can arise when glutaredoxin and thioredoxin pathways are overwhelmed or disrupted, producing persistent protein glutathionylation, intermolecular disulfides, and irreversible thiol oxidation. Unlike a generic increase in reactive oxygen species, the concept emphasizes cysteine chemistry, protein conformation, and the enzymes that write or reverse disulfide bonds. Cardiovascular research links this stress to atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, diabetic cardiomyopathy, hypertrophy, and heart failure because contractile, metabolic, endothelial, and inflammatory proteins depend on precisely regulated thiol states The defining event is not oxidation itself but failure of regulated thiol exchange, which changes protein folding, enzyme activity, adhesion, and signaling in a site-specific manner[1][2].

Disulfide formation can be damaging or protective according to the protein and compartment. In ischemic cardiomyocytes, FMO2 acts as a chaperone that catalyzes disulfide formation in unfolded or misfolded proteins through its GVSG motif, reduces the unfolded-protein response, and limits CHOP- and caspase-12-associated apoptosis; deleting FMO2 worsens survival, whereas cardiomyocyte overexpression protects infarcted hearts in experimental systems. In pulmonary vascular cells, an oxidant-induced disulfide between cyclin D and CDK4 inhibits kinase activity, lowers retinoblastoma-protein phosphorylation, and arrests proliferation. Pulmonary arterial hypertension shows reduced CDK4 disulfide formation, while auranofin restores this redox brake and reduces experimental vascular remodeling FMO2-mediated folding and inhibitory kinase disulfides show that adding or removing a disulfide can be protective depending on the protein and cellular compartment involved[1][2][3].

Redox switches also control vascular barrier function and thrombosis. TNIK phosphorylates ezrin-radixin-moesin proteins to drive TNF-dependent endothelial contraction and permeability, but hydrogen-peroxide-mediated oxidation of TNIK Cys202 forms an inhibitory intermolecular disulfide. Integrins couple mechanical force to redox state at focal adhesions; disulfide reduction in platelet integrin αIIbβ3 by ERp5 under shear helps regulate adhesion, making thiol chemistry relevant to thromboinflammation. These pathways suggest therapeutic opportunities in ischemia, pulmonary hypertension, edema, diabetes-associated vascular inflammation, and platelet activation. Yet a global antioxidant cannot reproduce protein- and site-specific disulfide control and may remove adaptive redox signals alongside harmful oxidation Auranofin and other redox-active compounds therefore require target-level validation because their net cardiovascular effect may reflect several thioredoxin, glutaredoxin, inflammatory, and metabolic pathways[2][3][4][5].

Research must distinguish regulated disulfide switches, proteotoxic accumulation, and disulfidptosis-like cell death. Static oxidation measurements do not show whether a cysteine modification is causal, reversible, compartmentalized, or merely a consequence of injury. Future studies should use redox proteomics, site-directed genetics, structural assays, live-cell sensors, microfluidic shear systems, and dynamic force measurements to map when specific disulfides form and how they change protein function. Mitochondrial dynamics and mitophagy should be measured because mitochondrial dysfunction increases reactive oxygen species and intersects with several programmed-death pathways and macrophage states. Therapeutic design should favor protein-, cysteine-, tissue-, and timing-specific modulation while monitoring immunity and normal redox adaptation. The most credible targets will be validated switches whose correction restores cardiovascular function without broadly suppressing oxidation Mapping reversible cysteine states during injury and recovery could identify intervention windows before abnormal bonds become irreversible protein damage or trigger downstream inflammatory cell death[1][4][5][6].

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Cat. No. Product Name Information Application Publication
HY-50767 Palbociclib
Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
CDK  
Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Luminal Breast Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
255
HY-50767C Palbociclib hydrochloride
Palbociclib (PD 0332991) hydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib hydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells. Palbociclib hydrochloride can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
CDK  
Liver Cancer   Ovarian Cancer   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Luminal Breast Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer   Acute Lymphoblastic Leukemia   Chronic Myelogenous Leukemia   Pancreatic Ductal Adenocarcinoma  
235
HY-16297A Abemaciclib
Abemaciclib (LY2835219) is a selective and BBB-permeable CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
CDK  
Neurological, Eye or Ear Disease   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Non-Small Cell Lung Cancer   Luminal Breast Cancer   HER-2 Positive Breast Cancer   Metastatic Breast Cancer   Metastatic Prostate Cancer  
128
HY-L011 Membrane Transporter/Ion Channel Compound Library
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 2,278 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

90
HY-L036 Covalent Screening Library
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 1,618 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

Structure Classified Libraries

87
HY-15777 Ribociclib
RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
CDK  
Neurological, Eye or Ear Disease   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Non-Small Cell Lung Cancer   Luminal Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
86
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L054 Endoplasmic Reticulum Stress Compound Library
Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer. MCE Endoplasmic Reticulum Stress Compound Library contains 379 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

Signaling Pathway Targeting Libraries

85
HY-L078 Gut Microbial Metabolite Library
Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods. In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 475 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Metabolism Focused Libraries

85
HY-L092 Glucose Metabolism Compound Library
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 1,777 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Signaling Pathway Targeting Libraries

85
HY-L095 Mechanoreceptors Compound Library
Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms. MCE offers a unique collection of 391 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

Signaling Pathway Targeting Libraries

85
HY-L134 Anti-Aging Natural Product Library
Aging is an unavoidable process, leading to cell senescence due to physiochemical changes in an organism. Aging cells cease to divide and drive the progression of illness through various pathways, resulting in the death of an organism ultimately. Anti-aging activities are primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. Natural products are known as effective molecules in anti-aging treatments, which delay the aging process through influencing several pathways and thus ensure an extended lifespan. MCE offers a unique collection of 193 natural products with validated anti-aging activity. MCE anti-aging natural product library is a useful tool for the study of aging-related diseases drugs and pharmacology.

Natural Product Screening Libraries Disease Focused Libraries

85
HY-14660 Dabrafenib
Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively.
Raf   CDK  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Non-Small Cell Lung Cancer  
84
HY-L029 Autophagy Compound Library
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 2,080 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Signaling Pathway Targeting Libraries

84
HY-L046 Anti-Cardiovascular Disease Compound Library
Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 2,468 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Disease Focused Libraries

84
HY-L059 Pyroptosis Compound Library
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 2,034 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L060 Cytoskeleton Compound Library
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 2,313 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L146 Metabolic Enzyme Compound Library
Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc. MCE designs a unique collection of 4,407 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.

Signaling Pathway Targeting Libraries

84
HY-L180 Mitophagy Compound Library
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 655 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Signaling Pathway Targeting Libraries

84
HY-L036P Covalent Screening Library Plus
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 6,121 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc. MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Structure Classified Libraries

83
HY-L064 Glutamine Metabolism Compound Library
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 1,827 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Signaling Pathway Targeting Libraries

83
HY-L088 Angiogenesis-Related Compound Library
Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer). MCE offers a unique collection of 3,660 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

Signaling Pathway Targeting Libraries

83
HY-L119 Potassium Channel Compound Library
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. There are four major classes of K channels: voltage-gated potassium channel, calcium-activated potassium channel, inwardly rectifying potassium channel and tandem pore domain potassium channel. There is growing evidence that dysfunction in potassium channels correlates with several diseases, such as chronic hypertension, diabetes, hypercholesterolemia and atherosclerosis, etc. MCE Potassium Channel Compound Library consists of 337 potassium channel inhibitor and activators, which is a useful tool to discover drugs for cardiovascular diseases and potassium channel research.

Signaling Pathway Targeting Libraries

83
HY-L125 Anti-Pulmonary Fibrosis Compound Library
Pulmonary fibrosis (PF), also known as diffuse interstitial pulmonary fibrosis, is a very common end-stage manifestation of several diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension, and scleroderma, characterised by excessive matrix deposition and destruction of the lung architecture, finally leading to respiratory insufficiency. PF has become a global disease with significantly increased incidence rate, and the most common form of pulmonary fibrosis is idiopathic pulmonary fibrosis (IPF). Lung fibrosis is a complex disease, a multitude of signal factors and signaling pathways is disrupted in this complex disease, such as TGF-β, Wnt, VEGF and PI3K–Akt. MCE offers a unique collection of 2,810 compounds with identified and potential anti-pulmonary fibrosis activity. MCE Anti-Pulmonary Fibrosis Compound Library is a useful tool for anti-pulmonary fibrosis drugs screening and other related research.

Disease Focused Libraries

83
HY-L155 Mitochondrial Toxicity Compound Library
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 545 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Compound Characteristic Classified Libraries Signaling Pathway Targeting Libraries

83
HY-L239 Steroid Hormones Library
Steroid hormones (also known as steroidal hormones) are a class of tetracyclic aliphatic hydrocarbon compounds derived from cholesterol. Typical representatives of steroid hormones include cortisol, aldosterone, testosterone, estradiol, among others. These hormones serve diverse regulatory functions within the body. For instance, aldosterone helps maintain the homeostasis of extracellular fluid volume and circulating blood volume; testosterone and estradiol primarily promote the development and maturation of male and female reproductive organs and regulate reproductive functions. MCE designs a unique collection of 71 steroid hormones. This library can be used for research related to metabolic or immune diseases, investigations into the mechanisms of action of nuclear receptor signaling pathways, as well as identification and quantitative analysis in metabolomics studies.

Compound Characteristic Classified Libraries

83
HY-L261 Classic FDA-Approved Drug Library
MCE Classic FDA-Approved Drug Library features a curated selection of marketed drugs that have achieved the highest prescription volumes and greatest clinical impact in global practice since 2006. The collection covers eight major therapeutic areas, including cardiovascular diseases, oncology, metabolic disorders, infectious diseases, central nervous system disorders, respiratory diseases, digestive system diseases, and immunological conditions. All compounds have been validated through long‑term clinical use and possess well‑defined molecular targets, well‑established pharmacokinetic properties, quantifiable efficacy endpoints, and comprehensive toxicological safety profiles. The library currently contains 167 representative drugs and is designed to serve as an efficient tool for drug repurposing, phenotypic screening, mechanism‑of‑action studies, and combination therapy strategy development.

Drug Repurposing Series

83
HY-L263 Energy Metabolites Library
Energy metabolism is the most fundamental biochemical process in living organisms, encompassing glycolysis, the TCA cycle, oxidative phosphorylation, the pentose phosphate pathway, and fatty acid oxidation. These core pathways directly regulate cell survival, proliferation, differentiation, and apoptosis. Dysregulation of energy metabolism is closely linked to major diseases including cancer, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders, and ischemia‑reperfusion injury. Targeting these metabolic pathways has become a frontier in drug discovery and mechanistic research. The MCE Energy Metabolite Compound Library features 89 structurally defined small‑molecule compounds. It covers energy substrates, pathway intermediates, coenzymes and redox carriers, nucleotide derivatives, and microenvironmental modulators. This library is applicable to research areas including tumor metabolism, insulin resistance, mitochondrial dysfunction, oxidative stress, neuroprotection, and cardiometabolic diseases, providing a high‑quality tool for mechanistic studies, biomarker discovery, and high‑throughput drug screening.

Signaling Pathway Targeting Libraries

83
HY-L919 MCE CNS BBB Lead-like Library
With the aging population and increasing competitive pressures, neurodegenerative diseases of the central nervous system (CNS) have become a serious medical challenge in modern society, including Parkinson's disease, Alzheimer's disease, brain tumors, and multiple sclerosis. However, the success rate of CNS drug development remains remarkably low, primarily due to the blood-brain barrier (BBB). The blood-brain barrier (BBB) is a semipermeable barrier structure that surrounds the microvasculature of the CNS. In capillaries, the wedged endothelial cells are tightly packed and wedge-shaped, lining the interior of the vessels to form extensive tight junctions. Along with a range of receptors, transporters, efflux pumps, and other cellular components, this barrier regulates the entry and exit of molecules between the bloodstream and the brain. The intact BBB blocks the passage of most blood-borne substances into the brain, preventing nearly 100% of large-molecule drugs and over 98% of small-molecule drugs from entering. Compared to non-CNS drugs, physicochemical properties such as hydrogen bonds, lipophilicity, and molecular weight significantly influence a compound's ability to cross the BBB. Using artificial intelligence (AI) algorithms to predict BBB permeability, a predicted value greater than 0.75 indicates that the compound has strong potential to cross the BBB, providing a promising starting point for CNS drug discovery.

Focused and target libraries

83
HY-LD005 DEL D Kit Cyclic Peptide Library
Cyclic peptide library have advantages such as high affinity, high selectivity, and suitability for targeting protein–protein interactions. Through DEL synthesis technology, the library size can achieve hundreds of millions. DEL cyclic peptide library have advantages like low cost andhigh screeing efficiency, making them valuable for discovering lead compounds against challenging drug targets. This cyclic peptide library is constructed with unnatural amino acids as building block, synthesized through DNA-compatible chemical reactions. Each cyclic peptide consist of six amino acids and constrained conformations such as side-chain cross-linking, disulfide bonds, and macrocyclization. These cyclic peptides exhibit significantly improved stability and druggability compared with linear peptides, filling the gap between small molecules and macromolecular biologics. Each cyclic peptide is uniquely conjugated to a DNA barcode sequence for molecular identification and sequencing decoding. MCE’s cyclic peptide library has8 independent sub-libraries, with a total molecular diversity of 1.2 billion. It is constructed via multi-round combinatorial assembly of building blocks and diverse cyclization strategies, facilitating the discovery of cyclic peptide leads for undruggable targets.

DNA Encoded Libraries

83
HY-12529 Ro-3306
Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.
CDK   Apoptosis  
Digestive System Disease   Breast Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Digestive System Inflammation  
75
HY-10492 Dinaciclib
Dinaciclib (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively.
CDK   Apoptosis  
Lung Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Triple-Negative Breast Cancer   SARS-CoV-2 Infection  
58
HY-13328 Sapanisertib
Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies.
mTOR   Apoptosis   Akt   ERK   CDK   Ribosomal S6 Kinase (RSK)   Collagen   HIF/HIF Prolyl-Hydroxylase   Wnt  
Melanoma   Ovarian Cancer   Blood Disease   Lung Fibrosis  
56
HY-10005 Flavopiridol
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
CDK   Autophagy   HIV   Apoptosis  
Neurological, Eye or Ear Disease   Breast Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection  
55
HY-N0750 Monocrotaline
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. .
Others  
Metabolic or Endocrine Disease   Liver Cancer   SARS-CoV-2 Infection  
48
HY-141511 Coppersensor 1
Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu+ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu+) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases.
Fluorescent Dye  
Cancer   Neurological, Eye or Ear Disease  
37
HY-W018746 EDTA disodium
EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
Environmental Pollutants   Biochemical Assay Reagents  
31
HY-N1362 Salvianolic acid B
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
Autophagy  
Blood or Cardio-cerebrovascular Disease  
25
HY-15434 NG25
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
MAP4K   MAP3K  
Inflammation or Immune System Disease   Breast Cancer   Obesity  
24
HY-N0171A Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
Bacterial   Apoptosis   Reactive Oxygen Species (ROS)   MDM-2/p53   Caspase   PARP   MMP   Bcl-2 Family   HIF/HIF Prolyl-Hydroxylase   TNF Receptor   Interleukin Related   NF-κB   mTOR   Lactate Dehydrogenase   CDK   Glutathione Peroxidase   SOD  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
24
HY-N0485 Liensinine Diperchlorate
Liensinine Diperchlor​ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlor​ate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlor​ate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.
Autophagy   Mitophagy  
Cancer   Digestive System Disease   Digestive System Inflammation   Cardiovascular Disease   Lung Fibrosis  
22
HY-113324 NADPH
NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms.
Endogenous Metabolite  
Cancer   Parkinson's Disease  
22
HY-P7110A VEGF165 Protein, Human (HEK293)
VEGF165 Protein, Human is a Vascular Endothelial Growth Factor A (VEGF-A) isoform. VEGF165 Protein is the growth factor that affects the angiogenesis, vasculogenesis and endothelial cell growth. VEGF165 Protein can binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin, and affects the motor neuron signaling pathway. VEGF165 Protein, Human (HEK293) is a human-derived VEGF165 Protein that can be expressed by HEK293.

Species: Human; Source: HEK293

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

19
HY-70037 Cinacalcet
Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.
CaSR  
Prostate Cancer   Cardiovascular Disease  
17
HY-113355 NADH
NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.
Endogenous Metabolite   Apoptosis  
Neurodegenerative Disease   Autoimmune Disease   Renal Disease   Ischemia-Reperfusion Injury  
11
HY-N0935 Ligustrazine hydrochloride
Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine hydrochloride reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine hydrochloride possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis.
Reactive Oxygen Species (ROS)   Akt   NO Synthase   Aminotransferases (Transaminases)  
Cerebrovascular Disease   Lipid Metabolism   Ischemia-Reperfusion Injury   Atherosclerosis and Inflammation  
11
HY-100343 GNE-495
GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
MAP4K  
Cancer   Obesity  
11
HY-N0264 Ligustrazine
Ligustrazine (Chuanxiongzine) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis.
Reactive Oxygen Species (ROS)   Akt   NO Synthase   Aminotransferases (Transaminases)  
Cerebrovascular Disease   Lipid Metabolism   Ischemia-Reperfusion Injury   Atherosclerosis and Inflammation  
11
HY-100196 Pyrroloquinoline quinone
Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function.

Source: cultures of methylotropic bacteria and tissues of mammals

Endogenous Metabolite  
Inflammation or Immune System Disease   Bacterial Infection  
9
HY-W107464 G6PDi-1
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells.
PDI  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
9
HY-P7312 VEGF164 Protein, Mouse
VEGF164 Protein, Mouse is a potent mediator of angiogenesis and binds the semaphorin receptor, neuropilin1.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

9
HY-100041 Bromobimane
Bromobimane (Monobromobimane) is a nonfluorescent and converts into fluorescent products when reacts with thiols. Bromobimane has potential applications in labeling thiols.
Fluorescent Dye  
8
HY-113325A NADP sodium hydrate
NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite  
Inflammation or Immune System Disease   Breast Cancer  
7
HY-F0002A NADP disodium salt
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

Source: Widespread

Endogenous Metabolite  
Metabolic or Endocrine Disease   Breast Cancer   Oxidative Stress and Inflammation  
7
HY-113325 NADP
NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Breast Cancer  
7
HY-108749 Olive oil
Olive oil (Cropure OL) is an oleaginous compound found in the fruit of the Olea europaea tree. Olive oil contains many phenolic components and exerts antioxidant activity. Olive oil exhibits hydroxyl radical scavenging, platelet aggregation inhibition and xanthine oxidase inhibitory activity. Olive oil can promote wound healing and relieve inflammation. Olive oil can be used for the research of inflammation, cancer, metabolic and cardiovascular disease, such as diabetic foot ulcers and inflammatory bowel disease.
Environmental Pollutants   Xanthine Oxidase  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Inflammatory Bowel Disease  
7
HY-100433 PACMA 31
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PDI  
Ovarian Cancer  
6
HY-P80929 VEGFA Antibody (YA013)
VEGFA Antibody (YA013) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VEGFA.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

6
HY-111754 DMX-5804
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.
MAP4K  
Cardiovascular Disease   Obesity  
5
HY-19562 PF-06260933
PF-06260933 is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
MAP4K  
Inflammation or Immune System Disease   Obesity  
5
HY-100432 LOC14
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding. LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells.
PDI  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
5
HY-12378 BQ-123
BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension.
Endothelin Receptor  
Blood or Cardio-cerebrovascular Disease  
4
HY-100830 NCB-0846
NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation.
Wnt   MAP4K   TGF-beta/Smad  
Neurological, Eye or Ear Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Hypertension   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
4
HY-113252 2-Methoxyestrone
2-Methoxyestrone is an estrogen metabolite with antimitotic activity. 2-Methoxyestrone acts as a liver-specific prohormone that undergoes demethylation to form active 2-hydroxyestrogens, and it can also interconvert with 2-Methoxyestradiol (HY-12033) via the 17β-hydroxysteroid dehydrogenase pathway. In the presence of all-trans retinoic acid, 2-Methoxyestrone exerts a strong, concentration-dependent inhibitory effect on cell growth. 2-Methoxyestrone delays the progression of pulmonary hypertension in rats, alleviates right ventricular and pulmonary vascular remodeling, and relieves proliferative pulmonary hypertension in rats. 2-Methoxyestrone can be used in studies related to proliferative pulmonary hypertension.
Endogenous Metabolite   Drug Metabolite  
Metabolic or Endocrine Disease  
3
HY-15917A L-Dithiothreitol
L-Dithiothreitol (DTT) is a reducing agent commonly used in various biochemical applications to break disulfide bonds in proteins, thereby denaturing proteins or preventing the formation of unwanted aggregates. DTT has a unique chemical property that cleaves the sulfur-sulfur bond in the disulfide bond to form a sulfhydryl group. This makes it a useful tool for protein purification, enzyme assays, and protein structure studies.
Biochemical Assay Reagents  
3
HY-P1032 Angiotensin I (human, mouse, rat)
Angiotensin I is a decapeptide hormone. Angiotensin I is the precursor of Angiotensin II (HY-13948). Angiotensin I can be used in the study of cardiovascular diseases such as hypertension and vasospasm.
Endogenous Metabolite   Angiotensin-converting Enzyme (ACE)  
Blood or Cardio-cerebrovascular Disease  
3
HY-107193 Bacitracin
Bacitracin is a polypeptide antibiotic against staphylococcal and pathogenic protozoa infections. Bacitracin inhibits cell wall biosynthesis and permeability through binding to the undecaprenyl pyrophosphate. Bacitracin inhibits macromolecular synthesis. Bacitracin is also a protein disulfide isomerase (PDI) inhibitor.

Source: Tracey I strain of Bacillus subtilis

Environmental Pollutants   PDI   Bacterial   Antibiotic  
Cancer   Viral Infection   Bacterial Infection  
3
HY-P7311 VEGF164 Protein, Rat (CHO)
VEGF164 Protein, Rat (CHO) is a potent mediator of angiogenesis and binds the semaphorin receptor, neuropilin1.

Species: Rat; Source: CHO

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

3
HY-W014841 Sodium hippurate, 98%
Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research. .
Keap1-Nrf2   Reactive Oxygen Species (ROS)   MMP   TGF-beta/Smad   Endogenous Metabolite  
Metabolic or Endocrine Disease   Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Pain   Cardiovascular Disease   Lung Fibrosis   Rheumatoid Arthritis  
2
HY-122895 E64FC26
E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity.
Apoptosis   PDI  
Cancer  
2
HY-P0012A Aviptadil acetate
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al.
SARS-CoV  
Inflammation or Immune System Disease  
2
HY-108801A Aflibercept (VEGF Trap)
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease.

Species: Human

VEGFR  
Colorectal Cancer   Hypertension  
2
HY-108801 Aflibercept
Aflibercept is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease.

Species: Human

VEGFR  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Non-Small Cell Lung Cancer  
2
HY-P0012 Aviptadil
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al.
SARS-CoV  
Inflammation or Immune System Disease  
2
HY-P9993 Peresolimab
Peresolimab is a humanized IgG1-κ antibody targeting to PD-1. Peresolimab potentially stimulates physiological immune inhibitory pathways to restore immune homeostasis. Peresolimab can be used in research of rheumatoid arthritis.

Species: Human

PD-1/PD-L1  
Inflammation or Immune System Disease  
2
HY-P99590 Sotatercept
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions.
TGF-β Receptor  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
2
HY-P1913 Calcitonin Gene Related Peptide II (rat)
Calcitonin Gene Related Peptide II rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide II rat can be used in the research of cardiovascular diseases.
CGRP Receptor  
Blood or Cardio-cerebrovascular Disease  
1
HY-N6881 Gypenoside XIII
Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis.
Others  
Cardiovascular Disease  
1
HY-P1913A Calcitonin Gene Related Peptide II (rat) TFA
Calcitonin Gene Related Peptide II rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide II rat TFA can be used in the research of cardiovascular diseases.
CGRP Receptor  
Blood or Cardio-cerebrovascular Disease  
1
HY-111117 3-Methyltoxoflavin
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM.
PDI  
Cancer   Neurological, Eye or Ear Disease  
1
HY-D1261 Naph-EA-mal
Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells. Ex: 488 nM; Em: 540 nM.
Fluorescent Dye  
1
HY-W329357 15:0 Lyso PC
15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.
Endogenous Metabolite  
Cardiovascular Disease  
1
HY-124745 KY-05009
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity.
MAP4K   Wnt   Apoptosis  
Neurological, Eye or Ear Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Digestive System Inflammation   Hypertension   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-B1228 Ribostamycin sulfate
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant KD of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections.

Source: Streptomyces ribosidicus

Antibiotic   PDI  
Bacterial Infection  
1
HY-100430 CCF642
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity.
Apoptosis   PDI  
Digestive System Disease   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation  
1
HY-B0150S Nicotinamide-d4
Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Sirtuin   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
1
HY-A0126A Epoprostenol sodium
Epoprostenol sodium (Prostaglandin I2) sodium salt, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation.
Endogenous Metabolite   Apoptosis  
Blood or Cardio-cerebrovascular Disease  
1
HY-W010572 1-Thioglycerol
1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.
Biochemical Assay Reagents  
1
HY-P7110 VEGF165 Protein, Human (P.pastoris)
VEGF165 Protein, Human (P.pastoris) is a Vascular Endothelial Growth Factor A (VEGF-A) isoform. VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis.

Species: Human; Source: P. pastoris

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

1
HY-P72775 VEGF120 Protein, Mouse
VEGF-A Protein is a key member of the VEGF family of cytokines.VEGF-A participates in angiogenesis, vasculogenesis, and endothelial cell growth, inducing endothelial cell proliferation, promoting cell migration, inhibiting cell apoptosis, and inducing vascular permeability.VEGF-A stimulates endothelial cell mitogenesis and cell migration.VEGF120 Protein, Mouse is the recombinant mouse-derived VEGF120 protein, expressed by E.coli , with tag free.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

1
HY-P7421 VEGF164 Protein, Mouse (P.pastoris)
VEGF164 Protein, Mouse (P.pastoris), a VEGF isoform splice variant, is more potent at inducing endothelial ICAM-1 expression by VEGFR-2, leukocyte migration by VEGFR-1, and inflammation and angiogenesis in the adult cornea.

Species: Mouse; Source: P. pastoris

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

1
HY-40136R cis-4-Hydroxy-L-proline (Standard)
cis-4-Hydroxy-L-proline (Standard) is the analytical standard of cis-4-Hydroxy-L-proline (HY-40136). This product is intended for research and analytical applications. cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension.
Reference Standards   Endogenous Metabolite  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-17503S2 (S)-Metoprolol-d7
(S)-Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].
Isotope-Labeled Compounds   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-17503S1 (R)-Metoprolol-d7
(R)-Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].
Isotope-Labeled Compounds   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-113252R 2-Methoxyestrone (Standard)
2-Methoxyestrone (Standard) is the analytical standard of 2-Methoxyestrone (HY-113252). This product is intended for research and analytical applications. 2-Methoxyestrone is an estrogen metabolite with antimitotic activity. 2-Methoxyestrone acts as a liver-specific prohormone that undergoes demethylation to form active 2-hydroxyestrogens, and it can also interconvert with 2-Methoxyestradiol (HY-12033) via the 17β-hydroxysteroid dehydrogenase pathway. In the presence of all-trans retinoic acid, 2-Methoxyestrone exerts a strong, concentration-dependent inhibitory effect on cell growth. 2-Methoxyestrone delays the progression of pulmonary hypertension in rats, alleviates right ventricular and pulmonary vascular remodeling, and relieves proliferative pulmonary hypertension in rats. 2-Methoxyestrone can be used in studies related to proliferative pulmonary hypertension.
Reference Standards   Endogenous Metabolite   Drug Metabolite  
Metabolic or Endocrine Disease  
/
HY-P3051A CKS-17 (dimer)
CKS-17 (dimer) is the dimer of CKS-17 (HY-P3051). CKS-17 (dimer) can be prepared by introducing a naturally occurring cysteine at the carboxyl terminus and dimerizing via a cysteine-disulfide bond. CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has a highly conserved amino acid sequence present in the transmembrane envelope proteins of numerous animal and human retroviruses. As an immunomodulatory epitope, CKS-17 exhibits inhibitory properties on a variety of immune functions.
Drug Derivative  
Inflammation or Immune System Disease   Viral Infection  
/
HY-P1435A NoxA1ds TFA
NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors.
NADPH Oxidase  
Blood or Cardio-cerebrovascular Disease  
/
HY-D2943 BG-SS-SulfoCy3
BG-SS-SulfoCy3 is a SulfoCy3-labeled SNAP tag fluorescent probe, which is linked by a disulfide bond to achieve selective labeling and controllable cleavage. BG-SS-SulfoCy3 can be used to study the endocytosis and trafficking of membrane proteins such as GPCRs.
Fluorescent Dye  
/
HY-P1948 Thioredoxin reductase peptide
Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. Thioredoxin reductase acts as a reductant of disulfide-containing proteins and plays crucial role in cellular antioxidant defense.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-N16650 Bisadinrone A
Bisadinrone A is a sesquiterpene found in Curcuma longa. Bisadinrone A can inhibit LDH release and shows significant anti-myocardial ischemia-reperfusion injury activity. Bisadinrone A can be used for the research of cardiovascular disease, such as ischemic heart disease.
Lactate Dehydrogenase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P11221A CLIKKPF acetate
CLIKKPF acetate is a specific peptide segment. CLIKKPF acetate can bind strongly to phosphatidylserine (PS) on the inner layer of the cell membrane. CLIKKPF acetate can enhance the targeting ability of nanoparticles. CLIKKPF acetate can be used in the research of cardiovascular diseases.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-P4201 JKC 301
JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking.
Vasopressin Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-W011814S Hexadecane-1-thiol-d33
Hexadecane-1-thiol-d33 is the deuterium labeled Hexadecane-1-thiol.
Isotope-Labeled Compounds  
/
HY-P6013 wt hMLN
wt hMLN is a microprotein that inhibits of SR Ca2+ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.
Calcium Channel  
/
HY-105697 Protoveratrine A
Protoveratrine A (NSC 7526; Protalba; Protoveratrin) is an alkaloid with strong cardiostimulant and vasoconstrictive effects, which can be used in the study of hypertension and other cardiovascular diseases.
Glutamate Dehydrogenase (GLDH)  
Blood or Cardio-cerebrovascular Disease  
/
HY-W1127976S 1,2-Dicarbadodecaborane(12)-1-thiol-10B10
1,2-Dicarbadodecaborane(12)-1-thiol-10B10 is a boron-10 labeled 1,2-Dicarbadodecaborane(12)-1-thiol.
Isotope-Labeled Compounds  
/
HY-70037S Cinacalcet-d3
Cinacalcet-d3 is the deuterium labeled Cinacalcet. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Isotope-Labeled Compounds   CaSR   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-132184S 5,6-Epoxyeicosatrienoic acid-d11
5,6-Epoxyeicosatrienoic acid-d11 (5,6-EET-d11) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid is one of the four major epoxyeicosatrienoic acid (EET) isomers metabolized from Arachidonic acid (HY-109590). 5,6-Epoxyeicosatrienoic acid induces peripheral vasodilation and lowers blood pressure by inhibiting T-type calcium channels (Cav3.2: IC50 = 0.54 μM). 5,6-Epoxyeicosatrienoic acid causes vasoconstriction in hypoxic pulmonary blood vessels via activating Rho kinase in a membrane depolarization-dependent manner. 5,6-Epoxyeicosatrienoic acid induces mechanical pain by activating TRPA1. 5,6-Epoxyeicosatrienoic acid can be used in studies related to hypoxic pulmonary vasoconstriction, mechanical hyperalgesia and hypertension.
Isotope-Labeled Compounds   Adrenergic Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-103684 RT-NH2
RT-NH2 is a RealThiol prototype without the carboxylic acid groups. RT-NH2 is fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probe.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-105390 Renin-IN-4
Renin-IN-4 is a Renin inhibitor. Renin-IN-4 can be used for the research of cardiovascular disease.
Renin  
Blood or Cardio-cerebrovascular Disease  
/
HY-N13380 6′‐O‐Galloylsalidroside
6’-O-Galloylsalidroside is an active component of Rhodiola. 6’-O-Galloylsalidroside is promising for research of Alzheimer’s disease, lung diseases, cerebrovascular disease, diabetes, cardiovascular disease and aging-related diseases.
Others  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P4087 Cys(Npys)-(Arg)9
Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection.
HIV  
HIV Infection   Squamous Cell Carcinoma  
/
HY-W777002 Famotidine-13C3
Famotidine-13C3 (MK-208-13C3) is the 13C3-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-107337S Delapril-d3 hydrochloride
Delapril-d3 (hydrochloride) is the deuterium labeled Delapril hydrochloride. Delapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases.
Isotope-Labeled Compounds   Angiotensin-converting Enzyme (ACE)  
Blood or Cardio-cerebrovascular Disease  
/
HY-W707517 Famotidine-d4
Famotidine-d4 (MK-208-d4) is the deuterated-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-D2930 BG-SS-SulfoCy5
BG-SS-SulfoCy5 (SNAP-SS-SulfoCy5) is a SulfoCy5-labeled SNAP tag fluorescent probe, linked by a disulfide bond. BG-SS-SulfoCy5 combines the specific recognition of SNAP-tag, the cleavability of disulfide bond, and the excellent optical properties of SulfoCy5. BG-SS-SulfoCy5 can be used for tracking the internalization of cell surface proteins and multiple labeling experiments.
Fluorescent Dye  
/
HY-W653969 Arotinolol-d5 hydrochloride
Arotinolol-d5 (hydrochloride) is deuterium labeled Arotinolol. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
Isotope-Labeled Compounds   5-HT Receptor   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-W009299S Octadecane-1-thiol-d37
Octadecane-1-thiol-d37 is the deuterium labeled Octadecane-1-thiol.
Isotope-Labeled Compounds  
/
HY-W1048533A Biotin-PEG2000-SH
Biotin-PEG2000-SH (Biotin-PEG2000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection.
Biochemical Assay Reagents  
/
HY-P2097 L-363564
L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research.
Renin  
Blood or Cardio-cerebrovascular Disease  
/
HY-17356G Fenofibrate (GMP)
Fenofibrate (GMP) is Fenofibrate (HY-17356) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
Cytochrome P450   Autophagy   PPAR  
Blood or Cardio-cerebrovascular Disease  
/
HY-N16469 Ruscin
Ruscin (Ruscoponticoside D; Neoruscine) is steroidal saponin found in Butcher’s Broom. Ruscin has multiple bioactivities and possesses a variety of pharmacological activities, including anti-inflammatory properties, platelet aggregation inhibition, pulmonary hypertension lowering properties, acute lung injury alleviation.
Others  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-130601 Thiol-PEG5-thiol
Thiol-PEG5-thiol (Bis-PEG5-thiol) is a bifunctional thiol cross-linker agent.
Biochemical Assay Reagents  
/
HY-D1066 NIR-Thiol dinitrobenzenesulfonate
NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. NIR-Thiol dinitrobenzenesulfonate responds to thiol with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-Thiol dinitrobenzenesulfonate is capable of imaging endogenously produced thiol in living cells and mice.
Fluorescent Dye  
/
HY-P5888 PKCε inhibitor peptide,myristoylated
PKCε inhibitor peptide,myristoylated (Myr-PKCε-) is a cell permeable myristic acid conjugated PKC peptide inhibitor that attenuates NO release in cultured human umbilical vein endothelial cells (HUVECs).
PKC  
Inflammation or Immune System Disease  
/
HY-167906S Hexadecyl 2-((4-Nitrophenyl)thio)acetate-13C2
Hexadecyl 2-((4-Nitrophenyl)thio)acetate-13C2 is the 13C-labeled Lunamarine (HY-167906). Lunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED).
Isotope-Labeled Compounds   Bacterial   Phosphodiesterase (PDE)  
Metabolic or Endocrine Disease  
/
HY-P992470 STT-5058
STT-5058 (ARGX-116; NN5058) is a human monoclonal antibody targeting ApoC3 and belongs to the class of ApoC3 inhibitors. STT-5058 exhibits pH-dependent circulation properties and binds to a unique epitope on ApoC3. STT-5058 reduces triglyceride levels and accelerates the clearance of atherogenic remnant lipoproteins containing ApoC3. STT-5058 can be used in research related to hypertriglyceridemia, dyslipidemia and cardiovascular diseases.

Species: Human

Apolipoprotein  
Cardiovascular Disease   Lipid Metabolism  
/
HY-P99696 Lerodalcibep
Lerodalcibep (LIB003) is a recombinant fusion protein of a PCSK9-binding domain (adnectin) and human serum albumin. Lerodalcibep is a Lipid-lowering agent. Lerodalcibep can be used for the research of hypercholesterolemia and cardiovascular diseases.
PCSK9  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P10352 Pediocin PA 1
Pediocin PA 1 is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA 1 shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA 1 can be used not only as a food biopreservative but also for research on listeriosis.
Bacterial  
Bacterial Infection  
/
HY-D3522 pH630 Deep Red maleimide, Thiol Reactive
pH630 Deep Red maleimide, Thiol Reactive is a fluorescent labeling reagent combining pH responsiveness and thiol targeting capabilities. It combines pH sensitivity and thiol-specific labeling, primarily used for highly specific, low-background fluorescent labeling and imaging of thiol-containing biomolecules in acidic environments (Ex/Em = 630/650 nm).
Fluorescent Dye  
/
HY-P4597 (H-Cys-Phe-OH)2 (disulfide bond)
(H-Cys-Phe-OH)2 (disulfide bond) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
Others  
/
HY-15893G DMOG (GMP)
DMOG (GMP) is the GMP level of DMOG (HY-15893). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DMOG (GMP) is a HIF-1α stabilizer. DMOG (GMP) promotes the osteogenic, angiogenic, and chondrogenic differentiation of stem cells by stabilizing the expression of HIF-1α. DMOG (GMP) can enhance the osteogenic and angiogenic differentiation potential of stem cells, thereby improving bone regeneration in bone defects. DMOG (GMP) can be used in the research of bone defect repair, vascularized bone regeneration, and the treatment of bone-related diseases (such as osteoporosis and femoral head necrosis) .
Autophagy   HIF/HIF Prolyl-Hydroxylase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P1752A Urocortin II, human TFA
Urocortin II, human TFA is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human TFA has an effect of promoting satiet and neuroprotective effect. Urocortin II, human TFA also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human TFA can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human TFA can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human TFA can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease.
CRFR   Bacterial   Parasite   NF-κB   ERK  
Metabolic or Endocrine Disease  
/
HY-P4450 Homoglutathione
Homoglutathione is a ubiquitous and indispensable tripeptide in eukaryotes with multi-facetted functions, many of which relate to cellular redox regulation. Homoglutathione has taste modifying effect.
Others  
/
HY-P991574 MEDI-5884
MEDI-5884 (REG-101) is a humanized IgG4Pκ neutralizing monoclonal antibody targeting endothelial lipase (EL), with an IC50 of 1.3 nM and 1.7 nM against human and cynomolgus monkey EL, respectively; its Kd values for human and cynomolgus monkey EL are 4.1 nM and 1.6 nM, respectively. MEDI-5884 increases plasma levels of HDL-C, apolipoprotein A1 (ApoA1) and phospholipids, while causing a slight increase in LDL-C and apolipoprotein B (ApoB) levels. MEDI-5884 can be used in research related to cardiovascular diseases, coronary heart disease, coronary atherosclerosis and stable coronary artery disease.

Species: Human

Lipase   Apolipoprotein  
Atherosclerosis and Inflammation   Atherosclerosis  
/
HY-P991133 Efranarelaxin alfa
Efranarelaxin alfa is a relaxin receptor agonist. Efranarelaxin alfa is promising for research of cardiovascular diseases and tissue repair.
RXFP Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-N0322GL Cholesterol (GMP Like, synthetic)
Cholesterol (GMP Like, synthetic) is Cholesterol (synthetic) (HY-N0322E) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cholesterol (synthetic) is a synthetic form of cholesterol. It is a lipid that sustains vital functions. Cholesterol (synthetic) can be used in research on cardiovascular diseases.
Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-B0377S Famotidine-13C,d3
Famotidine-13C,d3 (MK-208-13C,d3) is the deuterated, 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-D2004 ATTO 488 streptavidin
ATTO 488 streptavidin is a fluorescent reagent that specifically targets and binds to biotin (biotin), formed by the conjugation of ATTO 488 with streptavidin (HY-P3152). ATTO 488 streptavidin enables visualization of the activity of streptavidin immobilized on the surface of polymeric nanoparticles, or acts as a fluorescent probe to detect the selective binding and internalization process of anti-HB-EGF/NA with cells expressing HB-EGF (with no such effect on cells that do not express this receptor). ATTO 488 streptavidin effectively verifies the function of streptavidin conjugated to the surface of nanoparticles and is suitable for research related to atherosclerotic cardiovascular diseases.
Fluorescent Dye  
Atherosclerosis and Inflammation  
/
HY-P3227 Cyclo(Ala-Arg-Gly-Asp-Mamb)
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension research.
Integrin  
Inflammation or Immune System Disease  
/
HY-P1930 Risuteganib
Risuteganib is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina.
Integrin  
Inflammation or Immune System Disease  
/
HY-P11857 Alkyne-GRWHPM-CONH-NH-CMK
Alkyne-GRWHPM-CONH-NH-CMK is a covalent Cathepsin S inhibitor (IC50=82 nM). Alkyne-GRWHPM-CONH-NH-CMK has an N-terminal alkyne handle for CuAAC functionalization that engages off-target protein disulfide isomerase PDIA1. Alkyne-GRWHPM-CONH-NH-CMK can be used for the research of autoimmune disorders.
Cathepsin  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-N5078 Terrestrosin K
Terrestrosin K, a steroidal saponin from Tribulus terrestris L., has potential to treat cardiovascular and cerebrovascular diseases.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-P5755A SWELYYPLRANL-NH2 TFA
SWELYYPLRANL-NH2 TFA is an E-cadherin and N-cadherin antagonist. SWELYYPLRANL-NH2 TFA inhibits phage clone binding to E- or N-cad/Fc chimeric protein (IC50: 0.7 and 0.09 μM respectively). SWELYYPLRANL-NH2 TFA inhibits cell aggregation. SWELYYPLRANL-NH2 can be used to promote drug delivery through epithelial and endothelial permeability barriers.
Others  
Cancer  
/
HY-N12019 Parishin K
Parishin K is a cardioprotective agent obtained from the roots of Gastrodia elata Bl. Parishin K can be used in cardiovascular disease research.
Biochemical Assay Reagents  
Blood or Cardio-cerebrovascular Disease  
/
HY-W176660S 3-Methylbut-2-ene-1-thiol-d6
3-Methylbut-2-ene-1-thiol-d6 is deuterated labeled 3-Methylbut-2-ene-1-thiol.
Isotope-Labeled Compounds  
/
HY-W653978 Cinacalcet-d4 hydrochloride
Cinacalcet-d4 (AMG-073-d4) hydrochlorideis deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Isotope-Labeled Compounds   Endogenous Metabolite   CaSR  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-14779S3 Riociguat-d3
Riociguat-d3 (BAY 632521-d3) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
Isotope-Labeled Compounds   Guanylate Cyclase  
Blood or Cardio-cerebrovascular Disease  
/
HY-76520S Sitaxsentan-13C6
Sitaxsentan-13C6 (IPI 1040-13C6) is 13C labeled Sitaxsentan (HY-76520). Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension.
Isotope-Labeled Compounds   Endothelin Receptor   TGF-β Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-126752R Ophthalmic acid (Standard)
Ophthalmic acid (Standard) is the analytical standard of Ophthalmic acid (HY-126752). This product is intended for research and analytical applications. Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a Ki of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research.
Reference Standards   Reactive Oxygen Species (ROS)  
Glucose Metabolism  
/
HY-P991758 Anti-Mouse PDGFRα Antibody (APA5)
Anti-Mouse PDGFRα Antibody (APA5) reacts with mouse PDGFRα. Anti-Mouse PDGFRα Antibody (APA5) can be used to block PDGFRα in vitro and in vivo. Anti-Mouse PDGFRα Antibody (APA5) can be used for the study of pulmonary hypertension. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).

Species: Mouse

PDGFR  
Pulmonary Hypertension  
/
HY-B0377S1 Famotidine-13C
Famotidine-13C (MK-208-13C) is the 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-B0130S1 Perindopril-d5
Perindopril-d5 (S-9490-d5) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension.
Isotope-Labeled Compounds   NF-κB   Angiotensin-converting Enzyme (ACE)   Sirtuin   STAT  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W778391 Bisphenol A-13C2
Bisphenol A-13C2 is 13C labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders.
Isotope-Labeled Compounds   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W192474S 1-(Furan-2-yl)ethane-1-thiol-d3
1-(Furan-2-yl)ethane-1-thiol-d3 is deuterated labeled 1-(Furan-2-yl)ethane-1-thiol.
Isotope-Labeled Compounds  
/
HY-F0002AR NADP disodium salt (Standard)
NADP (disodium salt) (Standard) is the analytical standard of NADP (disodium salt). This product is intended for research and analytical applications. NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite   Reference Standards  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-108715R Real Thiol (Standard)
Real Thiol (Standard) is the analytical standard of Real Thiol (HY-108715). This product is intended for research and analytical applications. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
Fluorescent Dye   Reference Standards  
/
HY-N18435 Komaroidine
Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight.
Bacterial   Reactive Oxygen Species (ROS)  
Infection  
/
HY-W010529S 2-Methylfuran-3-thiol-d3
2-Methylfuran-3-thiol-d3 is deuterated labeled 2-Methylfuran-3-thiol.
Isotope-Labeled Compounds  
/
HY-W010572R 1-Thioglycerol (Standard)
1-Thioglycerol (Standard) is the analytical standard of 1-Thioglycerol. This product is intended for research and analytical applications. 1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.
Biochemical Assay Reagents   Reference Standards  
/
HY-N0750R Monocrotaline (Standard)
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. .
Reference Standards   Others  
Cancer   Metabolic or Endocrine Disease  
/
HY-P2512 Phytochelatin 2 (PC2)
Phytochelatin 2, a short phytochelatin, is a key plant peptide binding heavy metals. Phytochelatins are a diverse set of plant compounds that chelate metals, protect against metal toxicity and function in metal homeostasis.
Others  
/
HY-P10342 Soystatin
Soystatin is a peptide extracted from soy protein, whose main activity is to inhibit the absorption of cholesterol. Soystatin, as a peptide with significant cholic acid binding ability, can be used in the study of cardiovascular diseases.
Others  
Cardiovascular Disease  
/
HY-P6013A wt hMLN TFA
wt hMLN (TFA) is a microprotein that inhibits of SR Ca2+ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.
Calcium Channel  
/
HY-12749AS Midodrine-d6 hydrochloride
Midodrine-d6 (hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine-d6 (hydrochloride) can strengthen vascular contraction. Midodrine-d6 (hydrochloride) can be used for the researches of cardiovascular disease, such as orthostatic hypotension.
Isotope-Labeled Compounds   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-N4305 Notoginsenoside FP2
Notoginsenoside FP2, a dammarane-Type Bisdesmoside isolated from the Fruit Pedicels of Panax notoginseng, has potential to treat cardiovascular disease.
Others  
Cardiovascular Disease  
/
HY-W1048533H Biotin-PEG1000-SH
Biotin-PEG1000-SH (Biotin-PEG1000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection.
Biochemical Assay Reagents  
/
HY-14779S Riociguat-13C,d6
Riociguat-13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-B0150S1 Nicotinamide-15N,13C3
Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Isotope-Labeled Compounds   Endogenous Metabolite   Sirtuin  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P991721 Ticalicibart
Ticalicibart is a humanized IgG4κ monoclonal antibody inhibitor targeting PCSK9. Ticalicibart has anti-hyperlipidaemic activity. Ticalicibart can be used for cardiovascular disease like hypercholesterolaemia research.

Species: Human

PCSK9  
Blood or Cardio-cerebrovascular Disease  
/
HY-W012814R 4-Methylcatechol (Standard)
4-Methylcatechol (Standard) is the analytical standard of 4-Methylcatechol. This product is intended for research and analytical applications. 4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation[1][2][3][4][5][6].
Reference Standards   Endogenous Metabolite   Apoptosis   Reactive Oxygen Species (ROS)  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-N6617 Norswertianolin
Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases.
Others  
Cardiovascular Disease  
/
HY-N0264R Ligustrazine (Standard)
Ligustrazine (Standard) (Chuanxiongzine (Standard)) is the analytical standard of Ligustrazine (HY-N0264). This product is intended for research and analytical applications. Ligustrazine (Chuanxiongzine) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis.
Reference Standards   Reactive Oxygen Species (ROS)   Akt   NO Synthase   Aminotransferases (Transaminases)  
Cerebrovascular Disease   Lipid Metabolism   Ischemia-Reperfusion Injury   Atherosclerosis and Inflammation  
/
HY-P1463A Calcitonin, eel TFA
Calcitonin, eel TFA is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.
Thyroid Hormone Receptor  
/
HY-W1048533C Biotin-PEG5000-SH
Biotin-PEG5000-SH (Biotin-PEG5000-Thiol) is a biotin PEG polymer containing a thiol (-SH). Biotin-labeled compounds can then be linked to avidin or streptavidin for further purification or detection.
Biochemical Assay Reagents  
/
HY-P1948A Thioredoxin reductase peptide TFA
Thioredoxin reductase peptide TFA corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. Thioredoxin reductase acts as a reductant of disulfide-containing proteins and plays crucial role in cellular antioxidant defense.
Others  
/
HY-P1463 Calcitonin, eel
Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.
Thyroid Hormone Receptor  
Metabolic or Endocrine Disease  
/
HY-W591476D m-PEG350-thiol
m-PEG350-thiol (mPEG350-SH) is a thiol-terminated polyethylene glycol ligand. m-PEG350-thiol participates in thiol-ene/thiol-yne click reactions to graft PEG chains onto hyperbranched and linear polyesters.
Biochemical Assay Reagents  
/
HY-17503S Metoprolol-d7
Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].
Isotope-Labeled Compounds   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P992008 PF-07868489
PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. PF-07868489 can be used for the research of pulmonary arterial hypertension (PAH). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

TGF-β Receptor  
Pulmonary Hypertension  
/
HY-70037AS Cinacalcet-d3 hydrochloride
Cinacalcet-d3 (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Isotope-Labeled Compounds   CaSR   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-N2558 Murrayone
Murrayone is a coumarin compound with antifungal and antiplatelet activities. Murrayone disrupts fungal redox homeostasis, impairs cell membrane integrity, inhibits sporulation, spore germination and hyphal growth, and causes morphological damage to fungal cells. Murrayone reduces the disease severity of blueberry fruits infected with Botrytis cinerea. Murrayone can be used in studies related to fungal infections and vascular diseases.
Fungal  
Blood or Cardio-cerebrovascular Disease   Fungal Infection  
/
HY-D1260 FM-red
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx).
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-W1048549C HOOC-PEG5000-SH
HOOC-PEG5000-SH (HOOC-PEG5000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability.
Biochemical Assay Reagents  
/
HY-90009S Tadalafil-d3
Tadalafil-d3 is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
Phosphodiesterase (PDE)  
Blood or Cardio-cerebrovascular Disease  
/
HY-P4087B Cys(Npys)-(Arg)9 acetate
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection.
HIV  
/
HY-Y0682S1 Ethylenediaminetetraacetic acid-d16
Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-100196S1 Pyrroloquinoline quinone-13C3 sodium
Pyrroloquinoline quinone-13C3 (PQQ-13C3) sodium is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function.
Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-135963 Thiol-PEG3-thiol
Thiol-PEG3-thiol (Bis-PEG3-thiol) is a thiol crosslinker used in the synthesis of PEG hydrogels.
Biochemical Assay Reagents  
/
HY-D0844F Biotin-glutathione oxidized TFA
Biotin-glutathione oxidized TFA ((N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA) is an inducer of protein S-glutathionylation and a detection probe for S-glutathionylated proteins. Biotin-glutathione oxidized TFA forms protein-glutathione disulfide adducts, mimics components of oxidative stress, and drives protein S-glutathionylation. Biotin-glutathione oxidized TFA enables the labeling, detection, localization and purification of proteins susceptible to S-glutathionylation.
Others  
/
HY-P99560 Tadocizumab
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research.

Species: Human

Integrin  
Blood or Cardio-cerebrovascular Disease  
/
HY-W1048549A HOOC-PEG2000-SH
HOOC-PEG2000-SH (HOOC-PEG2000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability.
Biochemical Assay Reagents  
/
HY-N9279 Dehydromonocrotaline
Dehydromonocrotaline is a mitochondrial respiratory chain complex I NADH oxidase inhibitor, with a IC50 of 62.06 μM and a Ki of 8.1 μM in rats. Dehydromonocrotaline exerts non-competitive inhibitory effects by modifying cysteine thiol groups on complex I, and does not bind to the NADH-binding site. Dehydromonocrotaline dissipates mitochondrial membrane potential and reduces ATP levels. Dehydromonocrotaline can be used in studies related to hepatotoxicity, pulmonary hypertension and liver tumors.
Endogenous Metabolite  
Liver Cancer   Pulmonary Hypertension  
/
HY-113325AR NADP sodium hydrate (Standard)
NADP sodium hydrate (Standard) is the analytical standard of NADP sodium hydrate (HY-113325A). This product is intended for research and analytical applications. NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite   Reference Standards  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-40136S cis-4-Hydroxy-L-proline-d3
cis-4-Hydroxy-L-proline-d3 is the deuterium labeled cis-4-Hydroxy-L-proline (HY-40136). cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension.
Isotope-Labeled Compounds   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P10887 Pegevongitide
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.
Tie   ANGPTL   SARS-CoV   Aquaporin   TNF Receptor   PAI-1   CXCR   P-selectin  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   SARS-CoV-2 Infection  
/
HY-B0150S2 Nicotinamide-13C6
Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Endogenous Metabolite   Sirtuin  
Cancer   Neurological, Eye or Ear Disease  
/
HY-W047191 D-Glucono-1,4-lactone
D-Glucono-1,4-lactone is a derivative of D-gluconic acid (HY-Y0569C). D-Glucono-1,4-lactone can be isolated from fruits, vegetables, honey, kombucha and wine. D-Glucono-1,4-lactone inhibits thrombin-induced arachidonic acid peroxidation and platelet activation. D-Glucono-1,4-lactone reduces superoxide anion production in thrombin-activated platelets. D-Glucono-1,4-lactone exerts antioxidant activity on platelets under oxidative stress conditions and prevents excessive platelet activation through antioxidant mechanisms. D-Glucono-1,4-lactone can be used in research related to cardiovascular diseases.
Drug Derivative  
Platelet Disease  
/
HY-W357818 Glycinexylidide
Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease.
Sodium Channel   NF-κB   MEK   ERK   Drug Metabolite  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity   Rheumatoid Arthritis  
/
HY-P1888 HIF-1 alpha (556-574)
HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis.
HIF/HIF Prolyl-Hydroxylase  
Blood or Cardio-cerebrovascular Disease  
/
HY-N2163 Mudanpioside C
Mudanpioside C is a protein disulfide isomerase (PDI) inhibitor with a human IC50 of 3.31 μM and human Kd of 3.9 μM. Mudanpioside C suppresses collagen-induced platelet aggregation, interferes with platelet activation, adhesion, and spreading. Mudanpioside C can be used for the research of cardiovascular diseases.
PDI  
Cardiovascular Disease  
/
HY-148748G Butyzamide (GMP)
Butyzamide (GMP) is Butyzamide (HY-148748) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay.
JAK   STAT   p38 MAPK  
Blood or Cardio-cerebrovascular Disease  
/
HY-W018746R EDTA disodium (Standard)
EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
Biochemical Assay Reagents   Reference Standards  
/
HY-P1930A Risuteganib hydrochloride
Risuteganib hydrochloride is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina.
Integrin  
Inflammation or Immune System Disease   Parkinson's Disease  
/
HY-110397G KP-457 (GMP)
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
MMP  
Blood or Cardio-cerebrovascular Disease  
/
HY-P991222 AMG-529
AMG-529 is a humanized monoclonal antibody against ASGR1 that binds to ASGR1, blocks ligand binding, and causes a dose-dependent increase in ALP (a biomarker of ASGR1 inhibition). AMG-529 can be used for the research of cardiovascular diseases.

Species: Human

Phosphatase  
Blood or Cardio-cerebrovascular Disease  
/
HY-DY1087 Coppersensor 1 (solution)
Coppersensor 1 (solution) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu+ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu+) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases.
Solvent and concentration: DMSO: 2 mM
Fluorescent Dye  
/
HY-14184S Macitentan-d4
Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Isotope-Labeled Compounds   Endothelin Receptor   Apoptosis  
Blood or Cardio-cerebrovascular Disease  
/
HY-P1752B Urocortin II, human acetate
Urocortin II, human acetate is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human acetate has an effect of promoting satiet and neuroprotective effect. Urocortin II, human acetate also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human acetate can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human acetate can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human acetate can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease.
CRFR   Bacterial   Parasite   NF-κB   ERK  
Metabolic or Endocrine Disease  
/
HY-D1262 BODIPY-TS
BODIPY-TS (Thiol-green 2) is a fast response and thiol-specific turn-on probe. BODIPY-TS utilizes the thiosulfonate scaffold as a thiol recognition unit. BODIPY-TS has low toxicity, and features high selectivity, low detection limit, and quantitative reaction to thiols. Ex: 490 nM; Em: 515 nM.
Fluorescent Dye  
/
HY-112486G TA-316 (GMP)
TA-316 (GMP) is TA-316 (HY-112486) produced by using GMP guidelines. GMP grade small molecules can be used as auxiliary agents in cell therapy. TA-316 is a c-MPL agonist and a thrombopoietin (TPO) receptor agonist.
Cyclin G-associated Kinase (GAK)  
Blood or Cardio-cerebrovascular Disease  
/
HY-P10352A Pediocin PA 1 TFA
Pediocin PA-1 TFA is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA-1 TFA shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA-1 TFA can be used not only as a food biopreservative but also for research on listeriosis.
Bacterial  
Infection  
/
HY-W002450 L-Cyclohexylalanine
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity.
Drug Derivative  
Blood or Cardio-cerebrovascular Disease  
/
HY-W591476B m-PEG750-thiol
m-PEG750-thiol (mPEG750-SH) is a thiolated methoxypolyethylene glycol oligomer. m-PEG750-thiol serves for the synthesis of gold nanorods (AuNR) and also acts as a side chain fragment precursor for post-polymerization Michael addition reactions. m-PEG750-thiol can be used in organic synthesis-related research.
Biochemical Assay Reagents  
/
HY-Y0682S Ethylenediaminetetraacetic acid-d12
Ethylenediaminetetraacetic acid-d12 is the deuterium labeled Ethylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-P1435 NoxA1ds
NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors.
NADPH Oxidase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990785 Etentamig
Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases.

Species: Human

CD3  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P5755 SWELYYPLRANL-NH2
SWELYYPLRANL-NH2 is an E-cadherin and N-cadherin antagonist. SWELYYPLRANL-NH2 inhibits phage clone binding to E- or N-cad/Fc chimeric protein (IC50: 0.7 and 0.09 μM respectively). SWELYYPLRANL-NH2 inhibits cell aggregation. SWELYYPLRANL-NH2 can be used to promote drug delivery through epithelial and endothelial permeability barriers.
Others  
Cancer  
/
HY-108715 Real Thiol
Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-P6365 APL180 TFA
APL180 TFA (L-4F) is an apolipoprotein AI mimetic peptide that enhances the anti-inflammatory activity of high-density lipoprotein (HDL). APL180 can be used in the study of cardiovascular diseases.
Apolipoprotein  
Blood or Cardio-cerebrovascular Disease  
/
HY-P10580A Vasculotide TFA
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability. Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury.
Cadherin   PI3K   Claudin   Tie   Akt  
Infection   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-138568 HPK1-IN-3
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs).
MAP4K  
Inflammation or Immune System Disease   Obesity  
/
HY-N2909 Aurantiamide
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models.
NF-κB   RIP kinase   Mixed Lineage Kinase  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Alzheimer's Disease   Parkinson's Disease   Obesity  
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HY-P99791 Orilanolimab
Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity.

Species: Human

Others  
Inflammation or Immune System Disease  
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HY-W591476 m-PEG1000-thiol
m-PEG1000-thiol (mPEG1000-SH) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials[2].
Biochemical Assay Reagents  
Cancer  
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HY-157149 DS21150768
DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has anticancer effects.
MAP4K  
Cancer   Obesity  
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HY-168972 Famlasertib
Famlasertib is a potent, brain-penetrant MAP4K inhibitor with IC50s value of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively. Famlasertib shows motor neuron protection and anti-inflammatory properties. Famlasertib can be used for the study of amyotrophic lateral sclerosis (ALS).
MAP4K   Mixed Lineage Kinase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Obesity  
/
HY-40136 cis-4-Hydroxy-L-proline
cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Breast Cancer   Cardiovascular Disease   Pulmonary Hypertension  
/
HY-129763 Di-4-ANEPPS
Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC50 remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias.
Fluorescent Dye  
Blood or Cardio-cerebrovascular Disease  
/
HY-P10580 Vasculotide
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability. Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury.
Tie   PI3K   Akt   Cadherin   Claudin  
Infection   Blood or Cardio-cerebrovascular Disease   Skin Inflammation  
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HY-117570 KSC-34
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PDI  
Neurological, Eye or Ear Disease  
/
HY-W012814 4-Methylcatechol
4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation.
Endogenous Metabolite   Apoptosis   Reactive Oxygen Species (ROS)  
Cancer   Digestive System Disease   Digestive System Inflammation   Cardiovascular Disease   Parkinson's Disease  
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HY-W027592 1H-1,2,4-Triazol-3-amine
1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.
Environmental Pollutants   MOFs  
/
HY-D1781 NTPAN-MI
NTPAN-MI is a fluorescent probe (excitation wavelength: 405 nm). NTPAN-MI is selectively activated after labeling unfolded proteins with exposed thiols, thereby reporting the degree of protein homeostasis.
Fluorescent Dye  
/
HY-P1752 Urocortin II, human
Urocortin II, human is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human has an effect of promoting satiet and neuroprotective effect. Urocortin II, human also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease.
CRFR   Bacterial   Parasite   NF-κB   ERK  
Metabolic or Endocrine Disease  
/
HY-126752 Ophthalmic acid
Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a Ki of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research.

Source: animal kingdom

Reactive Oxygen Species (ROS)  
Glucose Metabolism  
/
HY-NP008 β-Lactoglobulin
β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products.
Lipocalin Family  
Inflammation or Immune System Disease  
/
HY-NP165 Advanced glycation end products
Advanced glycation end products (AGEs) are a series of stable compounds generated through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. Advanced glycation end products are often used as targets to evaluate the inhibitory effects of anti-glycation compounds. Advanced glycation end products can be applied to research on diabetes, cardiovascular and cerebrovascular diseases, inflammation, aging, and other conditions.
Biochemical Assay Reagents  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P4153 Enlicitide chloride
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC50 of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders.
PCSK9  
Blood or Cardio-cerebrovascular Disease  
/
HY-W012530 Phenylpyruvic acid
Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity.
Endogenous Metabolite   PDI  
Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-160623 Rentosertib
Rentosertib (INS018 055) (compound 112) is the orally active TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively.
MAP4K   TGF-beta/Smad   Cadherin   Interleukin Related  
Colorectal Cancer   Prostate Cancer   Digestive System Inflammation   Obesity   Lung Fibrosis  
/
HY-P73471 VEGF121 Protein, Human (HEK293)
VEGF121 Protein is a subtype of Vascular Endothelial Growth Factor A (VEGF-A). VEGF-A is a key member of the VEGF family of cytokines that can promote neovascularization and increase vascular permeability. VEGF121 Protein, Human (HEK293) is the recombinant human-derived VEGF121 protein, expressed by HEK293 , with tag free. The total length of VEGF121 Protein, Human (HEK293) is 147 a.a., with molecular weight of ~19.9 & 17.0 kDa, respectively.

Species: Human; Source: HEK293

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

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HY-P72280 VEGF-A Protein, Pig (His)
The VEGF-A protein is a multifunctional growth factor that is essential for promoting angiogenesis, vasculogenesis, and endothelial cell growth. Its multiple effects include inducing endothelial cell proliferation, promoting migration, inhibiting apoptosis, and increasing vascular permeability. VEGF-A Protein, Pig (His) is the recombinant pig-derived VEGF-A protein, expressed by E. coli , with N-6*His labeled tag.

Species: Pig; Source: E. coli

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

/
HY-P73473 VEGF164 Protein, Canine (HEK293)
VEGFA Protein is a vascular endothelial growth factor that is active in angiogenesis and endothelial cell growth. VEGFA Protein induces endothelial cell proliferation, promotes cell migration, inhibits cell apoptosis, and induces vascular permeability. VEGF164 Protein, Canine (HEK293) is the recombinant canine-derived VEGF164 protein, expressed by HEK293 , with tag free.

Species: Canine; Source: HEK293

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

/
HY-P72057A PLY Protein, Streptococcus pneumoniae serotype 4 (N-His)
The PLY protein, a cholesterol-dependent toxin, induces cytolysis by forming pores in host membranes with a significant conformational change and oligomeric pore complex formation. Cholesterol is crucial for binding, insertion, and pore formation. PLY Protein, Streptococcus pneumoniae serotype 4 (N-His) is the recombinant PLY protein, expressed by E. coli , with N-His labeled tag.

Species: Others; Source: E. coli

/
HY-P75820 IFI30 Protein, Human (HEK293, His)
IFI30 is a lysosomal thiol reductase that plays a critical role in reducing protein disulfide bonds in the lysosomal environment. This enzymatic activity is critical for complete unfolding of proteins for lysosomal degradation. IFI30 Protein, Human (HEK293, His) is the recombinant human-derived IFI30 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P76122 VEGF164 Protein, Rat (sf9)
The VEGF164 protein is a growth factor critical for vasculogenesis, vasculogenesis, and endothelial cell growth, inducing proliferation, promoting migration, inhibiting apoptosis, and enhancing vascular permeability. It binds to FLT1/VEGFR1, KDR/VEGFR2, heparan sulfate, heparin, NRP1 and DEAR/FBXW7-AS1 receptors. VEGF164 Protein, Rat (sf9) is the recombinant rat-derived VEGF164 protein, expressed by Sf9 insect cells , with tag free.

Species: Rat; Source: Sf9 insect cells

Cytokines and Growth Factors VEGF & VEGFR VEGF VEGF-A

/
HY-P704192 PLY Protein, Streptococcus pneumoniae serotype 4
The PLY protein, a cholesterol-dependent toxin, induces cytolysis by forming pores in host membranes with a significant conformational change and oligomeric pore complex formation. Cholesterol is crucial for binding, insertion, and pore formation. PLY Protein, Streptococcus pneumoniae serotype 4 is the recombinant others-derived PLY protein, expressed by E. coli, with tag free.

Species: Others; Source: E. coli

/
HY-P75316 CUTC Protein, Human (His)
CUTC proteins potentially regulate copper homeostasis by binding Cu(1+) of each subunit, suggesting a role in the control of cellular copper levels. As a homotetramer, the tetrameric arrangement of CUTC suggests cooperative behavior in managing copper ions. CUTC Protein, Human (His) is the recombinant human-derived CUTC protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

/
HY-P705519 Ifi30 Protein, Mouse (His)

Species: Mouse; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P7891 Cystatin SA/CST2 Protein, Human (HEK293, His)
Cystatin SA/CST2 Protein, Human (HEK 293, His) is a recombinant cystatin SA/CST2 protein with His tag. Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans.

Species: Human; Source: HEK293

Enzymes & Regulators Protease Inhibitors Cystatin Family Cystatin-2

/
HY-P72057 PLY Protein, Streptococcus pneumoniae serotype 4 (sf9, His-Myc)
The PLY protein, a cholesterol-dependent toxin, induces cytolysis by forming pores in host membranes with a significant conformational change and oligomeric pore complex formation. Cholesterol is crucial for binding, insertion, and pore formation. PLY Protein, Streptococcus pneumoniae serotype 4 (sf9, His-Myc) is the recombinant PLY protein, expressed by sf9 insect cells , with N-10*His, C-Myc labeled tag.

Species: Others; Source: Sf9 insect cells

/
HY-P703536 SARS-CoV-2 NSP3 Protein (His)
The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (His) is the recombinant virus-derived NSP3, expressed by E. coli, with N-His labeled tag.

Species: Virus; Source: E. coli

Viral Proteins

/
HY-P703539 SARS-CoV-2 NSP7 Protein (His-Avi)
The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. SARS-CoV-2 NSP7 Protein (His-Avi) is the recombinant virus-derived NSP7, expressed by E. coli, with C-His-Avi labeled tag.

Species: Virus; Source: E. coli

Viral Proteins

/
HY-P705431 METTL7B Protein, Human (His)

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

/
HY-P86376 VEGFA Antibody (YA6068)
VEGFA Antibody (YA6068) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VEGFA.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P85795 VEGFA Antibody (YA5487)
VEGFA Antibody (YA5487) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to VEGFA.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P82375 APE1 Antibody (YA2120)
APE1 Antibody (YA2120) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APE1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P83104 Cystatin B Antibody (YA2849)
Cystatin B Antibody (YA2849) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cystatin B.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P86547 VEGF Receptor 1 Antibody (YA6239)
VEGF Receptor 1 Antibody (YA6239) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VEGF Receptor 1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P81840 Peroxiredoxin 2 Antibody (YA1585)
Peroxiredoxin 2 Antibody (YA1585) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Peroxiredoxin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P89165 Streptolysin O Antibody
Streptolysin O Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Streptolysin O.

Host: Rabbit; Reactivity: Streptococcus pyogenes

Polyclonal Antibodies Primary Antibodies

/
HY-P80929A VEGFA Antibody (YA013)(PBS only)
VEGFA Antibody (YA013) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VEGFA.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P81840A Peroxiredoxin 2 Antibody (YA1585)(PBS only)
Peroxiredoxin 2 Antibody (YA1585) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Peroxiredoxin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P83104A Cystatin B Antibody (YA2849)(PBS only)
Cystatin B Antibody (YA2849) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cystatin B.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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Keywords

disulfide stress | cardiovascular disease | thiol redox homeostasis | protein disulfides | oxidative protein folding | pulmonary hypertension | endothelial permeability | thromboinflammation