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Kidney Function, Electrolyte Balance, and Blood Pressure Regulation

Chronic Inflammation Oxidative Stress Diabetes Metabolic Diseases

Renal tubular ion transport provides a unifying framework for kidney function, electrolyte balance, and long-term blood-pressure regulation because renal sodium excretion controls extracellular fluid volume and pressure natriuresis stabilizes arterial pressure around a set point. The field has developed from classical renin-angiotensin-aldosterone system models of arterial-pressure and volume homeostasis to integrated transporter-based models in which nephron sodium handling, renal perfusion pressure, local signaling, and potassium balance interact. Pressure natriuresis is impaired in hypertension, and experimental hypertension shows region-specific regulation of renal sodium transporters, making the kidney and distal nephron central research targets for explaining salt sensitivity and sustained increases in blood pressure. Dietary potassium has also become a major mechanistic focus because renal distal-tubule coordination of sodium and potassium excretion depends on interacting epithelial cell types, ion channels, transporters, and ATPases[1][2][3].

Within this network, angiotensin II and aldosterone couple hormonal sensing to renal sodium retention and potassium handling. When angiotensin II or aldosterone levels are inappropriately elevated, their antinatriuretic actions shift pressure natriuresis to higher pressure levels; intrarenal angiotensin II acts directly on tubular sodium transport and constricts efferent arterioles. Aldosterone acts mainly through mineralocorticoid receptors in the distal nephron and collecting duct and stimulates sodium absorption in part through the epithelial sodium channel, ENaC. ENaC therefore functions as a final effector of RAAS control of sodium excretion, while bradykinin provides a counter-regulatory pathway: B2-receptor activation stimulates phospholipase C and decreases ENaC open probability, promoting natriuresis. Potassium regulation intersects this circuitry through NCC and other distal-nephron pathways; a potassium-rich intake can produce renal sodium loss despite elevated aldosterone, and aldosterone-independent downregulation of the thiazide-sensitive NaCl cotransporter contributes to this natriuretic and antihypertensive response[3][4][5][6].

These pathways define several therapeutic and disease-research applications. ACE inhibition reduces blood pressure mainly through blockade of angiotensin II formation, while enhancement of bradykinin signaling contributes to the natriuretic and antihypertensive actions of ACE inhibition in the distal nephron. Mineralocorticoid-receptor antagonism targets aldosterone-dependent renal and cardiovascular effects, and abnormal aldosterone secretion or mutations affecting mineralocorticoid receptor, ENaC, or their regulators can disturb blood pressure and electrolyte balance. Genetic and experimental models further show that altered distal-nephron transport can generate blood-pressure and potassium phenotypes: PAR2 deficiency impairs renal sodium and potassium balance, whereas GILZ deficiency increases NCC activity and produces hyperkalemia-related features resembling familial hyperkalemic hypertension. These observations make ENaC, NCC, mineralocorticoid signaling, and renal protease/GPCR pathways mechanistically relevant entry points for hypertension and electrolyte-disorder research[4][5][6][7][8].

Important gaps persist in how these pathways are integrated across nephron segments and physiological states. The mechanisms linking renal perfusion pressure to sodium excretion remain incompletely understood, and future work must clarify how renal sympathetic activity, local inflammation, vascular-tubular signaling, and transporter regulation jointly impair pressure natriuresis. Potassium research likewise requires resolution of how altered dietary potassium is sensed and how that signal reaches distinct epithelial cells of the distal tubule. Bradykinin studies identify another translational question: whether genetic variation in B2-receptor or kallikrein-kinin components can predict responses to RAAS blockade. Together, these unresolved problems support research centered on integrated renal ion-transport networks, with pressure natriuresis, RAAS, ENaC/NCC regulation, and sodium-potassium coupling as linked determinants of kidney function and blood-pressure control[1][2][3][6].

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Cat. No. Product Name Information Application Publication
HY-13948B Angiotensin II human TFA
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
Angiotensin Receptor   Apoptosis  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
258
HY-13948A Angiotensin II human acetate
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
Angiotensin Receptor   Apoptosis  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Viral Infection   Digestive System Inflammation   Cardiovascular Disease  
258
HY-100381 Nigericin sodium salt
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC.

Source: Streptomyces hygroscopicus

Potassium Channel   NOD-like Receptor (NLR)   Bacterial   Antibiotic   Pyroptosis   Wnt   β-catenin  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Ovarian Cancer   Bacterial Infection   Depression   Hypertension   Lung Fibrosis   Rheumatoid Arthritis  
258
HY-127019 Nigericin
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC.
Potassium Channel   NOD-like Receptor (NLR)   Bacterial   Antibiotic   Pyroptosis   Wnt   β-catenin  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Ovarian Cancer   Bacterial Infection   Depression   Hypertension   Lung Fibrosis   Rheumatoid Arthritis  
258
HY-13948 Angiotensin II human
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
Angiotensin Receptor   Apoptosis  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Viral Infection   Digestive System Inflammation   Cardiovascular Disease  
258
HY-D0814 DAPI dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells. DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
DNA Stain   Sodium Channel  
Neurological, Eye or Ear Disease  
178
HY-100545 BAPTA-AM
BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.
Potassium Channel  
Cardiovascular Disease   Alzheimer's Disease  
155
HY-18723 Yoda 1
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation.
Piezo Channel   Akt   ERK   Potassium Channel  
Pancreatic Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Lung Fibrosis  
120
HY-L011 Membrane Transporter/Ion Channel Compound Library
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 2,278 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

90
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L054 Endoplasmic Reticulum Stress Compound Library
Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer. MCE Endoplasmic Reticulum Stress Compound Library contains 379 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

Signaling Pathway Targeting Libraries

85
HY-L091 Lipid Metabolism Compound Library
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 1,026 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Signaling Pathway Targeting Libraries

85
HY-L092 Glucose Metabolism Compound Library
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 1,777 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Signaling Pathway Targeting Libraries

85
HY-L095 Mechanoreceptors Compound Library
Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms. MCE offers a unique collection of 391 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

Signaling Pathway Targeting Libraries

85
HY-L029 Autophagy Compound Library
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 2,080 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Signaling Pathway Targeting Libraries

84
HY-L146 Metabolic Enzyme Compound Library
Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc. MCE designs a unique collection of 4,407 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.

Signaling Pathway Targeting Libraries

84
HY-L180 Mitophagy Compound Library
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 655 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Signaling Pathway Targeting Libraries

84
HY-L018 TGF-beta/Smad Compound Library
The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc. MCE designs a unique collection of 458 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Signaling Pathway Targeting Libraries

83
HY-L224 Diarrhea-Related Traditional Chinese Medicine Active Compound Library
Diarrhea is a disease symptom, and the pathophysiologic basis of diarrhea is a disturbance in intestinal water and electrolyte balance, which may be due to increased secretion of osmotically active electrolytes (secretory diarrhea) or increased intake of osmotically active substances (osmotic diarrhea). Food poisoning, pathogenic bacterial infections, and intestinal-related diseases can all contribute to the development of diarrhea. Traditional Chinese Medicine (TCM) considers diarrhea to be a symptom of an imbalance in the body's systems, particularly related to the functions of the spleen and stomach. Spleen qi deficiency, dampness-heat, liver and spleen disharmony are closely related to diarrhea. Many types of Chinese herbs regulate the function of diarrhea, such as: Dysosmae Verspiellis Rhixoma Et Radix, Ginkgo Semen, Forsythiae Fructus, and Campsis Flos. MCE can provide 2,478 active monomers that can be obtained from TCM herbs with diarrhea-regulating functions, which can be applied to drug development and disease mechanism research.

Traditional Chinese Medicine Libraries

83
HY-L239 Steroid Hormones Library
Steroid hormones (also known as steroidal hormones) are a class of tetracyclic aliphatic hydrocarbon compounds derived from cholesterol. Typical representatives of steroid hormones include cortisol, aldosterone, testosterone, estradiol, among others. These hormones serve diverse regulatory functions within the body. For instance, aldosterone helps maintain the homeostasis of extracellular fluid volume and circulating blood volume; testosterone and estradiol primarily promote the development and maturation of male and female reproductive organs and regulate reproductive functions. MCE designs a unique collection of 71 steroid hormones. This library can be used for research related to metabolic or immune diseases, investigations into the mechanisms of action of nuclear receptor signaling pathways, as well as identification and quantitative analysis in metabolomics studies.

Compound Characteristic Classified Libraries

83
HY-17412 Minocycline hydrochloride
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
Bacterial   Antibiotic   HIF/HIF Prolyl-Hydroxylase   Apoptosis   MDM-2/p53   Potassium Channel   Calcium Channel  
Metabolic or Endocrine Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Depression   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection   Lung Fibrosis  
76
HY-B0285A Amiloride hydrochloride
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
Sodium Channel   TRP Channel   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Pain   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection  
72
HY-B0285 Amiloride
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
Sodium Channel   TRP Channel   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Pain   Digestive System Inflammation   Cardiovascular Disease  
72
HY-19545A SCH-23390 hydrochloride
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
Dopamine Receptor   5-HT Receptor   Potassium Channel  
Depression   Alzheimer's Disease   Obesity  
35
HY-13771 Ursodeoxycholic acid
Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active.
G protein-coupled Bile Acid Receptor 1   FXR   Angiotensin-converting Enzyme (ACE)   Endogenous Metabolite  
Cancer   SARS-CoV-2 Infection  
32
HY-17504 Rosuvastatin Calcium
Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
HMG-CoA Reductase (HMGCR)   Autophagy   Potassium Channel   Bacterial  
Prostate Cancer   Viral Infection   Bacterial Infection   Cardiovascular Disease   Glucose Metabolism   Alzheimer's Disease  
29
HY-15206 Glibenclamide
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide can induce autophagy.
Potassium Channel   Mitochondrial Metabolism   Autophagy   CFTR   P-glycoprotein  
Digestive System Disease   Ovarian Cancer   Digestive System Inflammation   Glucose Metabolism   Alzheimer's Disease  
28
HY-129047 Trypsin
Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation.
Ser/Thr Protease   Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
27
HY-19414 MLN-4760
MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
Angiotensin-converting Enzyme (ACE)  
Hypertension   Obesity  
25
HY-B0185 Lidocaine
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.
Sodium Channel   MEK   ERK   NF-κB   Apoptosis  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection   Obesity   Rheumatoid Arthritis  
23
HY-B0368 Captopril
Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM.
Angiotensin-converting Enzyme (ACE)  
Cancer   Viral Infection   Glucose Metabolism   SARS-CoV-2 Infection   Hypertension  
23
HY-N1584 Halofuginone
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
DNA/RNA Synthesis   TGF-beta/Smad   Parasite   Sodium Channel   Calcium Channel  
Inflammation or Immune System Disease   Ovarian Cancer   Parasitic Infection   Pulmonary Hypertension  
22
HY-A0181 Adenosine monophosphate
Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Endogenous Metabolite   Adenosine Receptor   HSV  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Viral Infection   SARS-CoV-2 Infection  
22
HY-P0206A Bradykinin acetate
Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
Bradykinin Receptor   Endogenous Metabolite   Ser/Thr Protease  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
19
HY-P0206 Bradykinin
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
Bradykinin Receptor   Endogenous Metabolite   Ser/Thr Protease  
Infection   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
19
HY-12403 Talfirastide
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
Angiotensin Receptor   Angiotensin-converting Enzyme (ACE)  
Inflammation or Immune System Disease   Hypertension  
18
HY-B0246 Carbamazepine
Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain.
Sodium Channel   Autophagy   Mitophagy   Potassium Channel   Calcium Channel   HDAC  
Breast Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension  
18
HY-W728531 Ac4ManNAz
Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Biochemical Assay Reagents   p38 MAPK   Potassium Channel   Mitochondrial Metabolism  
Cancer  
17
HY-112558 AZ3451
AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.
Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
16
HY-B0211 Riluzole
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
Sodium Channel   GABA Receptor  
Cancer   Alzheimer's Disease   Parkinson's Disease  
16
HY-108896 Icatibant acetate
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively.
Bradykinin Receptor  
Inflammation or Immune System Disease  
14
HY-12404 Diminazene aceturate
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
Parasite   Angiotensin-converting Enzyme (ACE)  
Inflammation or Immune System Disease   Parasitic Infection  
14
HY-17446 Icatibant
Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
Bradykinin Receptor  
Metabolic or Endocrine Disease  
14
HY-B0331A Enalapril maleate
Enalapril maleate (MK-421 maleate) is an orally active angiotensin-converting enzyme inhibitor. Enalapril maleate blocks the conversion of angiotensin I to angiotensin II, regulates the renin-angiotensin system, reduces preload and afterload, and decreases plasma angiotensin II levels. Enalapril maleate inhibits apoptosis, reduces nitric oxide metabolite levels, stabilizes endothelial cells, enhances endothelial antioxidant defense, scavenges reactive oxygen species (ROS), and alleviates neuronal damage. Enalapril maleate attenuates glutathione depletion, protein/lipid oxidation, tissue damage, and type III collagen immunolabeling in organs of diabetic rats. Enalapril maleate reduces systolic blood pressure and urinary albumin excretion, and delays the progression of diabetic cardiac/renal injury. Enalapril maleate is used in research related to asymptomatic left ventricular dysfunction, congestive heart failure, Alzheimer's disease, diabetes mellitus, acute myocardial infarction, atrial fibrillation, hypertension, cerebral ischemia, chronic heart failure, and single-ventricle physiology.
Angiotensin-converting Enzyme (ACE)   Apoptosis   Reactive Oxygen Species (ROS)  
Cerebrovascular Disease   Glucose Metabolism   Alzheimer's Disease   Hypertension   Myocardial Infarction   Heart Failure   Atrial Fibrillation  
13
HY-B0331 Enalapril
Enalapril (MK-421) is an orally active angiotensin-converting enzyme inhibitor. Enalapril blocks the conversion of angiotensin I to angiotensin II, regulates the renin-angiotensin system, reduces preload and afterload, and decreases plasma angiotensin II levels. Enalapril inhibits apoptosis, reduces nitric oxide metabolite levels, stabilizes endothelial cells, enhances endothelial antioxidant defense, scavenges reactive oxygen species (ROS), and alleviates neuronal damage. Enalapril attenuates glutathione depletion, protein/lipid oxidation, tissue damage, and type III collagen immunolabeling in organs of diabetic rats. Enalapril reduces systolic blood pressure and urinary albumin excretion, and delays the progression of diabetic cardiac/renal injury. Enalapril is used in research related to asymptomatic left ventricular dysfunction, congestive heart failure, Alzheimer's disease, diabetes mellitus, acute myocardial infarction, atrial fibrillation, hypertension, cerebral ischemia, chronic heart failure, and single-ventricle physiology.
Angiotensin-converting Enzyme (ACE)   Apoptosis   Reactive Oxygen Species (ROS)  
Cerebrovascular Disease   Glucose Metabolism   Alzheimer's Disease   Hypertension   Myocardial Infarction   Heart Failure   Atrial Fibrillation  
13
HY-B1232 Metyrapone
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression.
Autophagy   Cytochrome P450  
Metabolic or Endocrine Disease   Fungal Infection  
12
HY-10119 Vorapaxar
Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.
Protease Activated Receptor (PAR)  
Viral Infection   Cardiovascular Disease  
12
HY-113313 Aldosterone
Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.
Endogenous Metabolite  
Hypertension   Heart Failure   Atrial Fibrillation  
11
HY-B0112 Minoxidil
Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM.
Potassium Channel  
Ovarian Cancer   Hypertension  
11
HY-W017018 L-Ornithine hydrochloride
L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
10
HY-N0603 20(S)-Ginsenoside Rg3
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
Sodium Channel   Potassium Channel   NF-κB   COX   Amyloid-β   Endogenous Metabolite  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   SARS-CoV-2 Infection   Alzheimer's Disease   Obesity   Rheumatoid Arthritis  
9
HY-111372 Finerenone
Finerenone (BAY 94-8862) is a third-generation, selective, and orally active nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (> 500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Mineralocorticoid Receptor  
Cardiovascular Disease   Glucose Metabolism  
9
HY-19870C Setmelanotide monoacetate
Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.
Melanocortin Receptor   Calmodulin   AMPK  
Blood or Cardio-cerebrovascular Disease   Respiratory Disease   Obesity   Fatty Liver Disease  
8
HY-110066 (Z)-Guggulsterone
(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection.
Apoptosis   VEGFR   Akt   Angiotensin-converting Enzyme (ACE)   SARS-CoV   FXR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Pain   Digestive System Inflammation   Hypertension   Obesity   Lung Fibrosis  
8
HY-B0251 Eplerenone
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV).
Mineralocorticoid Receptor   Endogenous Metabolite  
Breast Cancer   Bacterial Infection   Atherosclerosis   Hypertension   Myocardial Infarction   Heart Failure   Type 2 Diabetes   Insulin Resistance   Obesity   Hyperthyroidism   Chronic Kidney Disease  
8
HY-113325A NADP sodium hydrate
NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite  
Inflammation or Immune System Disease   Breast Cancer  
7
HY-F0002A NADP disodium salt
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

Source: Widespread

Endogenous Metabolite  
Metabolic or Endocrine Disease   Breast Cancer   Oxidative Stress and Inflammation  
7
HY-113325 NADP
NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Breast Cancer  
7
HY-B0561 Spironolactone
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca2+ channels to exert antihypertensive effects.
Mineralocorticoid Receptor   Androgen Receptor   Autophagy   Calcium Channel  
Prostate Cancer   Viral Infection   Glucose Metabolism   Parkinson's Disease   Hypertension  
7
HY-148800 Suzetrigine
Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy.
Sodium Channel  
Neurological, Eye or Ear Disease  
7
HY-18206 Lisinopril
Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
Angiotensin-converting Enzyme (ACE)  
Lung Cancer   Breast Cancer   Viral Infection   Glucose Metabolism   Hypertension  
6
HY-B0504 Creatinine
Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Endogenous Metabolite   GABA Receptor   iGluR  
Metabolic or Endocrine Disease   Prostate Cancer   Neurodegenerative Disease   SARS-CoV-2 Infection  
6
HY-P0078 TRAP-6
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.
Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
6
HY-W009356A L-Cystine monohydrochloride
L-Cystine monohydrochloride is an amino acid. L-Cystine is converted to L-Cysteine in the body. Moreover, L-Cystine/L-Cysteine conversion system is a channel on the cell membrane, which can maintain the internal REDOX homeostasis of E. coli.
Biochemical Assay Reagents  
5
HY-B0504S Creatinine-d3
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Cancer   Metabolic or Endocrine Disease  
5
HY-113414 Deoxycorticosterone
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM. Deoxycorticosterone could acts as an immune stimulator in fish.
Endogenous Metabolite   Mineralocorticoid Receptor  
Inflammation or Immune System Disease  
5
HY-W013175 Uridine 5'-monophosphate disodium salt
Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
Endogenous Metabolite   Cholinesterase (ChE)   Potassium Channel   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation   Cardiovascular Disease  
4
HY-N9435 28-Homobrassinolide
28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis.
Others  
Metabolic or Endocrine Disease  
4
HY-16276 Osilodrostat
Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS).
Mineralocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Cardiovascular Disease   SARS-CoV-2 Infection  
4
HY-122542B PPACK TFA
PPACK TFA is a potent, peptidic inhibitor targeting thrombin and granzyme GZMK. PPACK TFA specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1 cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK TFA exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK TFA binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK TFA is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases.
Protease Activated Receptor (PAR)   Thrombin   NF-κB  
Allergic Asthma   Atherosclerosis and Inflammation   Atherosclerosis  
4
HY-101981 Uridine 5'-monophosphate
Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
Endogenous Metabolite   Cholinesterase (ChE)   Potassium Channel   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Cardiovascular Disease  
4
HY-D0155 Zinpyr-1
Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn2+ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis.
Fluorescent Dye  
4
HY-N6691 Veratridine
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow.
Sodium Channel  
Neurological, Eye or Ear Disease  
4
HY-P1314 2-Furoyl-LIGRLO-amide
2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0..
Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
3
HY-W010991 N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system.
Angiotensin-converting Enzyme (ACE)  
3
HY-D1498 Mag-Fluo-4 AM
Mag-Fluo-4 AM, an analog of Fluo-4 AM (HY-101896), is an intracellular Mg2+ (Kd = 4.7 mM) indicator and a Ca2+ (Kd = 22 μM) indicator. Mag-Fluo-4 AM suitable for monitoring high concentrations and rapidly changing Ca2+ signals, and changes in intracellular Mg2+ homeostasis (Ex/Em = 496/525 nm).
Fluorescent Dye  
3
HY-13716 Noscapine
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier.
Opioid Receptor   Apoptosis  
Cancer   Digestive System Disease   Depression   Pain   Digestive System Inflammation  
2
HY-B1438 Canrenone
Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
Mineralocorticoid Receptor  
Cardiovascular Disease  
2
HY-15833 Chlorthalidone
Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
Sodium Chloride Cotransporter (NCC)  
Cardiovascular Disease   SARS-CoV-2 Infection  
2
HY-B1472 Deoxycorticosterone acetate
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria.
Mineralocorticoid Receptor  
Metabolic or Endocrine Disease   Hypertension  
2
HY-P1309 PAR-4 Agonist Peptide, amide
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
2
HY-P9993 Peresolimab
Peresolimab is a humanized IgG1-κ antibody targeting to PD-1. Peresolimab potentially stimulates physiological immune inhibitory pathways to restore immune homeostasis. Peresolimab can be used in research of rheumatoid arthritis.

Species: Human

PD-1/PD-L1  
Inflammation or Immune System Disease  
2
HY-P1308 SLIGRL-NH2
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).
Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
2
HY-108065 3'-Sialyllactose
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

Source: Human milk

NF-κB  
Inflammation or Immune System Disease  
1
HY-B1477 Clopamide
Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.
Sodium Chloride Cotransporter (NCC)  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Cardiovascular Disease  
1
HY-P0204 Endothelin-3, human, mouse, rabbit, rat
Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis.
Endothelin Receptor   Integrin  
Neurological, Eye or Ear Disease  
1
HY-P2256 H3K4(Me2) (1-20)
H3K4(Me2) (1-20) is a histone peptide. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
Others  
1
HY-W040307 Saccharopine
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-Y1117 Melamine
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models.
Drug Metabolite   NADPH Oxidase   TGF-β Receptor   COX   ROS Kinase   Apoptosis   NF-κB  
Bladder Cancer   Renal Disease   Male Reproductive System Disease   Alzheimer's Disease  
1
HY-P9939 Burosumab
Burosumab (KRN23) is a humanized FGF23-neutralizing antibody. By neutralizing FGF23, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia.

Species: Human

Others  
Cancer   Metabolic or Endocrine Disease  
1
HY-P0298A [Des-Arg9]-Bradykinin acetate
[Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.
Bradykinin Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
1
HY-N0321 Caftaric acid
Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities.
Others  
Inflammation or Immune System Disease   Cardiovascular Disease   Parkinson's Disease  
1
HY-W040307B Saccharopine hydrochloride
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-W008646 7,8-Dihydro-L-biopterin
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases.
SOD   Apoptosis   NO Synthase  
Neurodegenerative Disease   Hypertension  
1
HY-W017018S4 L-Ornithine-d7 hydrochloride
L-Ornithine-d7 hydrochloride is the d7-labeled L-Ornithine hydrochloride (HY-W017018). L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Isotope-Labeled Compounds   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
1
HY-Y1147 Diethyl maleate
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].
Biochemical Assay Reagents  
1
HY-B0150S Nicotinamide-d4
Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Sirtuin   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
1
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis.
Endothelin Receptor   Integrin  
Neurological, Eye or Ear Disease  
1
HY-19837 BMS-986120
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects.
Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
1
HY-108065A 3'-Sialyllactose sodium
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

Source: human milk

NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
1
HY-P7266 MIP-5/CCL15 Protein, Human
MIP-5/CCL15 Protein, Human is a CC chemokine with strong chemotactic properties towards myeloid cells such as dendritic cells, monocytes, neutrophils and some T-lymphocytes. MIP-5/CCL15 Protein, Human binds to chemokine receptors CCR1 and CCR3 and plays a key role in leukocyte recruitment and inflammatory disease development. development. MIP-5/CCL15 Protein, Human is a recombinant human MIP-5/CCL15 (Q22-I113) expressed by E. coli.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL15

1
HY-P7763 HCC-1/CCL14 Protein, Human (HEK293, His)
HCC-1/CCL14 Protein, Human (HEK293, His) is a CC chemokine with weak activity against human monocytes, promotes monocyte, eosinophil and T-lymphocyte chemotaxis, and mediates allergic airway inflammation and cancer. HCC-1/CCL14 Protein, Human (HEK293, His) is a recombinant human HCC-1/CCL14(T20-N93) expressed by HEK293 with a his tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL14

1
HY-P7196 HCC-4/CCL16 Protein, Human (CHO)
HCC-4/CCL16 Protein, Human (CHO) is a CC chemokine that specifically attracts lymphocytes, dendritic cells and monocytes, increases their adhesion and has myelosuppressive activity. HCC-4/CCL16 Protein, Human (CHO) interacts with CCR1, CCR2, CCR5 and CCR8 to mediate inflammatory and cancer responses. HCC-4/CCL16 Protein, Human (CHO) is a recombinant human HCC-4/CCL16 (Q24-Q120) expressed by CHO.

Species: Human; Source: CHO

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL16

1
HY-P7245 MCP-4/CCL13 Protein, Human
MCP-4/CCL13 Protein, Human is a CC family chemokine with chemotactic effects on basophils, monocytes, macrophages, immature dendritic cells and T cells. CCL13 binds to CCR1, CCR2, CCR3, CCR5, and CCR11 chemokine receptors and is able to induce key immunomodulatory responses through its effects on regulatory muscle, epithelial, and endothelial cells. MCP-4/CCL13 Protein, Human is a recombinant human MCP-4/CCL13 (Q24-T98) protein expressed by E.coli.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL13

1
HY-B0504S5 Creatinine-15N
Creatinine-15N (NSC13123-15N) is the 15N-labeled Creatinine (HY-B0504). Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-P0206S1 RPP-(Gly-13C2,15N)-FSPFR TFA
RPP-(Gly-113C2,15N)-FSPFR TFA is 13C- and 15N-labeled Bradykinin (HY-P0206). Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
Isotope-Labeled Compounds   Ser/Thr Protease   Endogenous Metabolite   Bradykinin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P5007 Copeptin (human)
Copeptin (human) is a peptide biochemical reagent corresponding to the 39 amino acid sequence at the C-terminus of human pre-provasopressin, which serves as a stable surrogate biomarker reflecting the secretion of arginine vasopressin (AVP). Copeptin (human) can be used in studies related to AVP secretion, fluid and osmotic homeostasis, stress responses, and cardiovascular biomarkers.
Cardiovascular Disease  
/
HY-13716R Noscapine (Standard)
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier[4].
Reference Standards   Opioid Receptor   Apoptosis  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-113313S2 Aldosterone-d4
Aldosterone-d4 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t
Isotope-Labeled Compounds   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-B1842S1 Fluroxypyr-d2
Fluroxypyr-d2 is the deuterium labeled Fluroxypyr (HY-B1842). Fluroxypyr is an auxin herbicide to control annual or perennial weeds. Fluroxypyr icauses auxin overdose or excessive endogenous auxin concentrations, thereby resulting in an imbalance of auxin homeostasis and interaction with other hormones in tissues.
Isotope-Labeled Compounds   Herbicide  
/
HY-B0285AS Amiloride-15N3 hydrochloride
Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2) channel.
Apoptosis   TRP Channel   Sodium Channel  
Metabolic or Endocrine Disease  
/
HY-W134328B Blue dextran (MW 10000)
Blue dextran (Dextran blue) (MW 10000) is a 10 kDa osmotic dextran. Blue dextran (MW 10000) penetrates all sublayers of the pre-epithelial mucus gel layer in the rat distal colon and is taken up by the nuclei of surface cells in the rat distal colonic mucosa. Blue dextran (MW 10000) is not blocked by the pre-epithelial mucus gel layer of the rat distal colon, which acts as a diffusion barrier.
Biochemical Assay Reagents  
/
HY-N16372 Pronqodine A
Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandin F1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation.

Source: Streptomyces strain

Indoleamine 2,3-Dioxygenase (IDO)   Quinone Reductase   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease  
/
HY-P990083A Tegoprubart (powder)
Tegoprubart (powder) (AT-1501 (powder)) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart (powder) suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart (powder) preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart (powder) is applicable to research related to kidney transplantation and kidney transplant rejection.
TNF Receptor  
Autoimmune Disease  
/
HY-P3545 5-Valine-angiotensin I
5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-N0390G L-Glutamine (GMP)
L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
mTOR   NF-κB   STAT   HIF/HIF Prolyl-Hydroxylase  
Inflammation or Immune System Disease   Ischemic Stroke   Osteoporosis   Osteoarthritis  
/
HY-P11626 Cyclo(Ala-Hyp)
Cyclo(Ala-Hyp) is an orally effective collagen-derived hydroxyproline-containing cyclic dipeptide that can be isolated from the culture supernatant of Lactobacillus plantarum. Cyclo(Ala-Hyp) has an AUC0-6h of 2.350 μg/mL·h, significantly higher than traditional collagen oligopeptides. Cyclo(Ala-Hyp) can be used in research related to liver and kidney function protection, skin care, and joint health.
Collagen  
Metabolic or Endocrine Disease  
/
HY-W013175R Uridine 5'-monophosphate disodium salt (Standard)
Uridine 5'-monophosphate (disodium salt) (Standard) is the analytical standard of Uridine 5'-monophosphate (disodium salt). This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
Endogenous Metabolite   Cholinesterase (ChE)   Reference Standards   Potassium Channel   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-118472R Benazeprilat (Standard)
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
Reference Standards   Drug Metabolite   Endogenous Metabolite   Angiotensin-converting Enzyme (ACE)  
Blood or Cardio-cerebrovascular Disease  
/
HY-W768772 Fluroxypyr-13C2,d2
Fluroxypyr-13C2,d2 is the deuterium labeled and 13C-labeled Fluroxypyr (HY-B1842). Fluroxypyr is an auxin herbicide to control annual or perennial weeds. Fluroxypyr icauses auxin overdose or excessive endogenous auxin concentrations, thereby resulting in an imbalance of auxin homeostasis and interaction with other hormones in tissues.
Isotope-Labeled Compounds   Herbicide  
/
HY-P3803 [D-Pro4,D-Trp7,9] Substance P (4-11)
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration.
Neurokinin Receptor  
Neurological, Eye or Ear Disease  
/
HY-119557 Buthiazide
Buthiazide (Butizide) is a diuretic compound that can be used for high blood pressure research.
Sodium Chloride Cotransporter (NCC)  
Cardiovascular Disease  
/
HY-111961 Epitizide
Epitizide, a benzothiadiazine, commonly found in combination Triamterene (HY-B0575), is used to produce diuresis.
Sodium Chloride Cotransporter (NCC)  
Metabolic or Endocrine Disease  
/
HY-P4985 γ3-MSH
γ3-MSH is derived from the N-terminal segment of pro-opiomelanocortin (POMC). γ3-MSH stimulates aldosterone secretion by human adrenal tumor cells in culture.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-126675G AS2863619 (GMP)
AS2863619 GMP is AS2863619 (HY-126675) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS2863619 is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets Stat5a-CDK8/19 to promote the differentiation of CD4+ T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects.
CDK   Apoptosis   TGF-beta/Smad   STAT  
Digestive System Disease   Periodontal Disease  
/
HY-P5978 Atriopeptin III (rat)
Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure.
Natriuretic Peptide Receptor (NPR)  
Blood or Cardio-cerebrovascular Disease  
/
HY-P1815 C-Type Natriuretic Peptide (1-53), human
C-Type Natriuretic Peptide (1-53), human is the 1-53 fragment of C-Type Natriuretic Peptide. C-Type Natriuretic Peptide is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P12125 TAT-Epsilon-V1-2 TFA
TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor. TAT-Epsilon-V1-2 TFA reduces chronic immune responses after heart transplantation. TAT-Epsilon-V1-2 TFA is applicable to research related to delayed graft function and acute kidney injury caused by renal ischemia-reperfusion injury.
PKC  
Inflammation or Immune System Disease  
/
HY-P4786 Acetyl-ACTH (7-24) (human, bovine, rat)
Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release.
Androgen Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-13716S Noscapine-13C,d3
Noscapine-13C,d3 is a 13C- labeled and deuterated labeled Noscapine. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier.
Isotope-Labeled Compounds   Apoptosis   Opioid Receptor  
Cancer  
/
HY-P10046 [Deamino-Pen1,Val4,D-Arg8]-vasopressin
[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
Vasopressin Receptor  
Metabolic or Endocrine Disease  
/
HY-112094S WNK-IN-11-d3
WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis.
WNK Kinase   Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-Y1890B Cremophor EL-10
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn2+ , Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses.
Biochemical Assay Reagents  
/
HY-P1930 Risuteganib
Risuteganib is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina.
Integrin  
Inflammation or Immune System Disease  
/
HY-W066890R 4-Nitrocatechol (Standard)
4-Nitrocatechol (Standard) is the analytical standard of 4-Nitrocatechol (HY-W066890). This product is intended for research and analytical applications. 4-Nitrocatechol is a Lipoxygenase inhibitor. 4-Nitrocatechol can serve as a ligand to stabilize the formation of metal complexes. As a (+) MALDI matrix, 4-Nitrocatechol significantly enhances the MALDI-MS detection and imaging of low-molecular-weight compounds in animal and plant tissue sections.
Reference Standards   Lipoxygenase   Biochemical Assay Reagents  
/
HY-W751098 Aldosterone-13C3
Aldosterone-13C3 is a 13C-labeled Aldosterone (HY-113313). Aldosterone is a primary mineralocorticoid and steroid hormone.
Isotope-Labeled Compounds  
/
HY-N0391G L-Citrulline (GMP)
L-Citrulline GMP is an orally active, blood-brain barrier permeable neutral α-amino acid. L-Citrulline GMP inhibits the mitochondrial translocation of Drp1 and maintains mitochondrial homeostasis via a NO-dependent pathway, thereby reducing excessive ROS production. Consequently, L-Citrulline GMP protects sperm DNA integrity, stabilizes the blood-testis barrier and improves semen quality. L-Citrulline GMP can be used in research related to male infertility, mycobacterial infection (tuberculosis) and radiation combined injury.
Dynamin   Reactive Oxygen Species (ROS)  
Genitourinary Inflammation   Mycobacterium Tuberculosis Infection  
/
HY-114457 Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABAA receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema.
Phospholipase  
Acute Lung Injury  
/
HY-N5010R Nepitrin (Standard)
Nepitrin (Standard) (Nepetin-7-glucoside (Standard)) is the analytical standard of Nepitrin (HY-N5010). This product is intended for research and analytical applications. Nepitrin (Nepetin-7-glucoside) is an orally active bradykinin and angiotensin antagonist isolated from Scrophularia striata. Nepitrin antagonizes the spasmogenic effects of Bradykinin and Angiotensin, thereby inhibiting inflammatory mediator pathways. Nepitrin is applicable to arthritis-related research.
Reference Standards   Bombesin Receptor   Angiotensin Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Arthritis  
/
HY-W011086R Tri-O-tolyl phosphate (Standard)
Tri-O-tolyl phosphate (Tri-O-cresyl phosphate; TOTP) (Standard) is an analytical standard of Tri-O-tolyl phosphate (HY-W011086). This product is intended for research and analytical applications. Tri-O-tolyl phosphate is an aryl phosphate compounds commonly utilized as flame retardants and lubricant additives across various industrie. Tri-O-tolyl phosphate has neurotoxicity and reproductive toxicity, decreasing cell viability, inhibiting cell proliferation, triggering cell cycle arrest, induceing apoptosis, causing mitochondrial dysfunction, disrupts calcium homeostasis.
Biochemical Assay Reagents   Reference Standards   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B1363S1 Bendroflumethiazide-d7
Bendroflumethiazide-d7 (Bendrofluazide-d7) is deuterium labeled Bendroflumethiazide (HY-B1363). Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus.
Isotope-Labeled Compounds   NKCC  
Blood or Cardio-cerebrovascular Disease  
/
HY-B0285S Amiloride-15N3
Amiloride-15N3 (MK-870-15N3) is 15N labeled Amiloride. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.
Isotope-Labeled Compounds   TRP Channel   Sodium Channel   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W017018S1 L-Ornithine-1,2-13C2 hydrochloride
L-Ornithine-1,2-13C2 hydrochloride is the 13C-labeled L-Ornithine hydrochloride (HY-W017018). L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Isotope-Labeled Compounds   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
/
HY-P6013A wt hMLN TFA
wt hMLN (TFA) is a microprotein that inhibits of SR Ca2+ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.
Calcium Channel  
/
HY-W017018B L-Ornithine monohydrochloride,suitable for cell culture
L-Ornithine monohydrochloride,suitable for cell culture is a CaSR activator and p38 activator suitable for cell culture. L-Ornithine monohydrochloride,suitable for cell culture inhibits ROS and supports urea cycle function. L-Ornithine monohydrochloride,suitable for cell culture can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
/
HY-106103 Seglitide
Seglitide (MK-678) is an orally active, selective SSTR2 agonist and somatostatin analog. Seglitide also acts as a competitive Somatostatin receptor antagonist, with pA2 values of 6.50, 6.24 and 6.09 against SS14, SS25 and SS28, respectively. Seglitide produces only weak, transient inhibition of myocardial contractility in isolated right atria of guinea pigs. Seglitide inhibits glucagon secretion and reduces circulating insulin levels. Seglitide causes a sustained, reversible reduction in elevated systolic blood pressure in streptozotocin (HY-13753)-induced diabetic rats, but exerts no effect on spontaneously hypertensive rats. Seglitide induces membrane hyperpolarization and inhibits electrical excitability. Seglitide induces concentration-dependent contraction and significant desensitization in isolated distal colon of rats. Seglitide can be used in research related to hypertension complicated with insulin-dependent diabetes mellitus.
Somatostatin Receptor  
Neurological, Eye or Ear Disease   Digestive System Disease   Glucose Metabolism   Hypertension  
/
HY-B0561S1 Spironolactone-d3
Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.
Isotope-Labeled Compounds   Mineralocorticoid Receptor   Androgen Receptor   Autophagy  
Cancer   Metabolic or Endocrine Disease  
/
HY-B0150S1 Nicotinamide-15N,13C3
Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Isotope-Labeled Compounds   Endogenous Metabolite   Sirtuin  
Cancer   Neurological, Eye or Ear Disease  
/
HY-B0561S4 Spironolactone-d6-1
Spironolactone-d6-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca2+ channels to exert antihypertensive effects.
Isotope-Labeled Compounds   Autophagy   Androgen Receptor   Mineralocorticoid Receptor   Calcium Channel  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-B1438S Canrenone-d6
Canrenone-d6 is the deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
Isotope-Labeled Compounds   Mineralocorticoid Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-B1193S Terfenadine-d3
Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
Isotope-Labeled Compounds   Apoptosis   Histamine Receptor   Potassium Channel   Na+/Ca2+ Exchanger   Caspase  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-101981S Uridine 5'-monophosphate-15N2
Uridine 5'-monophosphate-15N2 (5'-​Uridylic acid-15N2) is the 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
Endogenous Metabolite   Isotope-Labeled Compounds   Cholinesterase (ChE)   Potassium Channel   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-127026S Quinaprilat-d5
Quinaprilat-d5 is a deuterium-labeled Quinaprilat (HY-127026). Quinaprilat is a nonsulfhydryl ACE inhibitor, the active diacid metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits bradykinin degradation. Quinaprilat primarily acts as a vasodilator, decreasing total peripheral and renal vascular resistance.
Angiotensin-converting Enzyme (ACE)  
Blood or Cardio-cerebrovascular Disease  
/
HY-118472 Benazeprilat
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
Drug Metabolite   Angiotensin-converting Enzyme (ACE)  
Hypertension  
/
HY-B0575S Triamterene-d5
Triamterene-d5 is deuterium labeled Triamterene (HY-B0575). Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor.
Sodium Channel  
Metabolic or Endocrine Disease  
/
HY-B1363S Bendroflumethiazide-d5
Bendroflumethiazide-d5 (Bendrofluazide-d5) is the deuterium labeled Bendroflumethiazide (HY-B1363).Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus.
Isotope-Labeled Compounds   NKCC  
Blood or Cardio-cerebrovascular Disease  
/
HY-W017018S3 L-Ornithine-d2 hydrochloride
L-Ornithine-d2 hydrochloride is the d2-labeled L-Ornithine hydrochloride (HY-W017018). L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Isotope-Labeled Compounds   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
/
HY-113414R Deoxycorticosterone (Standard)
Deoxycorticosterone (Standard) is the analytical standard of Deoxycorticosterone. This product is intended for research and analytical applications. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.
Reference Standards   Endogenous Metabolite  
/
HY-W008646R 7,8-Dihydro-L-biopterin (Standard)
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases.
Reference Standards   SOD   Apoptosis   NO Synthase  
/
HY-113325AR NADP sodium hydrate (Standard)
NADP sodium hydrate (Standard) is the analytical standard of NADP sodium hydrate (HY-113325A). This product is intended for research and analytical applications. NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.
Endogenous Metabolite   Reference Standards  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D2335 SERTlight
SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-P3624 Cenderitide
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research.
Guanylate Cyclase  
Hypertension  
/
HY-B0150S2 Nicotinamide-13C6
Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Endogenous Metabolite   Sirtuin  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P1469 Bradykinin (1-6)
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).
Bradykinin Receptor  
Metabolic or Endocrine Disease   Cardiovascular Disease  
/
HY-P10886 Zifogaptide
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc.
Gap Junction Protein   Claudin  
Skin Inflammation  
/
HY-P1888 HIF-1 alpha (556-574)
HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis.
HIF/HIF Prolyl-Hydroxylase  
Blood or Cardio-cerebrovascular Disease  
/
HY-W661499 Orellanine
Orellanine, a nephrotoxic alkaloid found in Cortinarius orellanus, is an orally active and selective non-competitive inhibitor of alkaline phosphatase. Orellanine chelates iron, generates reactive oxygen species (ROS), induces DNA scission, forms ortho-semiquinone radicals, downregulates antioxidant defenses, and inhibits mitochondrial function. Orellanine induces caspase 8/9-mediated apoptosis. Orellanine inhibits synthesis of proteins, RNA, DNA, and mitochondrial protein synthesis, with metabolic activation required for cell-free protein synthesis inhibition. Orellanine can be used for the research of metastatic clear cell renal cell carcinoma, acute renal failure, chronic renal insufficiency, and kidney damage.

Source: Cortinarius orellanus

Phosphatase   Apoptosis   Reactive Oxygen Species (ROS)   Caspase  
Cancer  
/
HY-W654041 Adenosine monophosphate-13C5
Adenosine monophosphate-13C5 (AMP-13C5) is 13C labeled Adenosine monophosphate. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-A0181S2 Adenosine monophosphate-d12 dilithium
Adenosine monophosphate-d12 (AMP-d12) dilithium is deuterium labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Isotope-Labeled Compounds   Endogenous Metabolite   Adenosine Receptor   HSV  
Infection   Metabolic or Endocrine Disease  
/
HY-N3320 Marmin
Marmin is a histamine receptor inhibitor and tracheal smooth muscle relaxant. Marmin antagonizes histamine- and methacholine-induced contraction of tracheal smooth muscle. Marmin inhibits histamine release from mast cells, and also blocks extracellular calcium influx via voltage-dependent calcium channels as well as calcium release from intracellular calcium stores, thereby effectively inhibiting calcium-mediated smooth muscle contraction. Marmin slightly enhances the relaxant effect of isoprenaline, and induces epithelial-dependent tracheal smooth muscle relaxation independent of nitric oxide, cGMP or β2-adrenergic pathways through the release of prostaglandin E2.
5-HT Receptor   Histamine Receptor  
Neurological, Eye or Ear Disease  
/
HY-P1930A Risuteganib hydrochloride
Risuteganib hydrochloride is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina.
Integrin  
Inflammation or Immune System Disease   Parkinson's Disease  
/
HY-B0247S Torsemide-d7
Torsemide-d7 is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-NP162 Recombinant Humanized Type XVII Collagen
Recombinant Humanized Type XVII Collagen is a transmembrane protein that forms hemidesmosomes. Recombinant Humanized Type XVII Collagen facilitates interactions between stem cells，surrounding cells，and the extracellular matrix，thereby regulating skin homeostasis，aging，and wound healing. Recombinant Humanized Type XVII Collagen also possesses unique cell adhesion sites and signal transduction functions，which can regulate cell migration，proliferation，and differentiation.
Biochemical Assay Reagents  
/
HY-N6075 Specneuzhenide
Specneuzhenide (Nuezhenide) is an orally active phenol glycoside isolated from Ligustrum sinense. Specneuzhenide exhibits anti-inflammatory, antioxidant, antifibrotic, antitumor, hypoglycemic, as well as cartilage- and kidney-protective activities. Specneuzhenide inhibits fibrosis by activating the AMPK pathway (Kd = 62 µM), alleviates inflammation and oxidative stress by regulating multiple signaling pathways (NF-κB, Wnt/β-catenin and HO-1/Nrf-2), and upregulates podocyte proteins to comprehensively protect renal function. Specneuzhenide can be used in research related to cancer, rheumatoid arthritis, pulmonary fibrosis, diabetic nephropathy and osteoarthritis.
AMPK   NF-κB   β-catenin   Wnt   Heme Oxygenase (HO)   Interleukin Related   Reactive Oxygen Species (ROS)   ROS Kinase   Cadherin   MMP   PD-1/PD-L1   Lysyl Oxidase  
Cancer   Glucose Metabolism   Renal Disease   Lung Fibrosis   Osteoarthritis   Rheumatoid Arthritis  
/
HY-W017018S5 L-Ornithine-15N2 hydrochloride
L-Ornithine-15N2 hydrochloride is the 15N-labeled L-Ornithine (hydrochloride) (HY-W017018). L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Isotope-Labeled Compounds   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
/
HY-B1438R Canrenone (Standard)
Canrenone (Standard) is the analytical standard of Canrenone. This product is intended for research and analytical applications. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
Reference Standards   Mineralocorticoid Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-W002450 L-Cyclohexylalanine
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity.
Drug Derivative  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990250 Anti-Mouse DKK3 Antibody (DKK3-4.22)
Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse DKK3 IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE).

Species: Mouse

Wnt  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-113151 18-Oxocortisol
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.
Mineralocorticoid Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-13948BS Angiotensin II human-13C6,15N TFA
Angiotensin II human-13C6,15N TFA (Ang II-13C6,15N TFA) is 13C- and 15N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions.
Isotope-Labeled Compounds  
Cancer  
/
HY-P2491 Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research.
Fluorescent Dye  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-113414S Deoxycorticosterone-d8
Deoxycorticosterone-d8 is the deuterium labeled Deoxycorticosterone. Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor.
Endogenous Metabolite  
/
HY-122940 Precocene II
Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity.

Source: Insects

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-B0504S1 Creatinine-13C
Creatinine-13C is the 13C-labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Metabolic or Endocrine Disease  
/
HY-P1484 Bradykinin (1-7)
Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.
Bradykinin Receptor  
Metabolic or Endocrine Disease   Cardiovascular Disease  
/
HY-W013175S2 Uridine 5'-monophosphate-13C9,15N2 disodium
Uridine 5'-monophosphate-13C9,15N2 disodium is the 13C and 15N labeled Uridine 5'-monophosphate disodium salt (HY-W013175). Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
Isotope-Labeled Compounds   Endogenous Metabolite   Cholinesterase (ChE)   Potassium Channel   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N9941 2,8-Dihydroxyadenine
2,8-Dihydroxyadenine is an endogenous metabolite that forms crystals in urine, leading to kidney stone formation and crystal deposition in the kidney. 2,8-Dihydroxyadenine induces crystal-induced tubular injury, inflammation, and fibrosis through crystal deposition in renal tubules, where crystals are excreted in urine, internalized by tubular epithelial cells, and transported to the interstitium. 2,8-Dihydroxyadenine upregulates CD44 expression near crystals, TNF-α signaling through NF-κB, and mTORC1 signaling, while inducing actin stress fiber formation and cytoskeletal remodeling. 2,8-Dihydroxyadenine downregulates epithelial-mesenchymal transition pathways and oxidative phosphorylation, and induces changes affecting inflammation, metabolism, and cell cycle regulation. 2,8-Dihydroxyadenine can be used in research on kidney disease, adenine phosphoribosyltransferase deficiency, and kidney stone disease.
Endogenous Metabolite   NF-κB   TNF Receptor   mTOR   Oxidative Phosphorylation  
Chronic Kidney Disease   Kidney Stones  
/
HY-103290 R715
R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice.
Bradykinin Receptor  
/
HY-W017018S L-Ornithine-d6 hydrochloride
L-Ornithine-d6 hydrochloride is the d6-labeled L-Ornithine hydrochloride (HY-W017018). L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Isotope-Labeled Compounds   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
/
HY-N5010 Nepitrin
Nepitrin (Nepetin-7-glucoside) is an orally active bradykinin and angiotensin antagonist isolated from Scrophularia striata. Nepitrin antagonizes the spasmogenic effects of Bradykinin and Angiotensin, thereby inhibiting inflammatory mediator pathways. Nepitrin is applicable to arthritis-related research.
Bombesin Receptor   Angiotensin Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Arthritis  
/
HY-113313S Aldosterone-d8
Aldosterone-d8 is a deuterium labeled Aldosterone. Aldosterone, produced in the adrenal zona glomerulosa, regulates blood pressure.
Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-P1815A C-Type Natriuretic Peptide (1-53), human TFA
C-Type Natriuretic Peptide (1-53), human TFA is the 1-53 fragment of C-Type Natriuretic Peptide. C-Type Natriuretic Peptide TFA is natriuretic peptide family peptide that is involved in the maintenance of electrolyte-fluid balance and vascular tone.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P5792 Atrial natriuretic peptide (3-28) (human)
Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)) is a peptide hormone that is synthesized and secreted by the atrial myocardium. Atrial natriuretic peptide (3-28) (human) is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis.
Endothelin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P3749 Mca-(ala7,lys(dnp)9)-bradykinin
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage.
Fluorescent Dye  
/
HY-107339 Deserpidine
Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.
Angiotensin-converting Enzyme (ACE)  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Hypertension  
/
HY-116887 N6-Methyladenine
N6-Methyladenine is a DNA epigenetic modification that involves the addition of a methyl group to the sixth position of adenine. N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases.
Endogenous Metabolite   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
Lung Cancer   Leukemia/Lymphoma/Myeloma   Glucose Metabolism  
/
HY-W017018R L-Ornithine hydrochloride (Standard)
L-Ornithine hydrochloride (Standard) is the analytical standard of L-Ornithine hydrochloride (HY-W017018). This product is intended for research and analytical applications. L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Reference Standards   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
/
HY-W145486 Calcium gluconate
Calcium gluconate is an orally effective calcium salt supplement. Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury.
Environmental Pollutants   Biochemical Assay Reagents  
Postoperative Pain   Acute Lung Injury   Osteoporosis  
/
HY-113313S1 Aldosterone-d7
Aldosterone-d7 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.
Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-N2909 Aurantiamide
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models.
NF-κB   RIP kinase   Mixed Lineage Kinase  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Alzheimer's Disease   Parkinson's Disease   Obesity  
/
HY-P99791 Orilanolimab
Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity.

Species: Human

Others  
Inflammation or Immune System Disease  
/
HY-N0394R L-Cystine (Standard)
L-Cystine (Standard) is the analytical standard of L-Cystine. This product is intended for research and analytical applications. L-Cystine, the extracellular form of L-Cysteine (HY-Y0337), is a nutritionally dispensable semiessential sulfur-containing amino acid, occurring in proteins of plants and animals. L-Cystine induces Nrf2 protein elevation in a Keap1 (HY-P75897)-dependent manner and activates Nrf2 transcription factor. L-cystine can elicit cytoprotection by reducing ROS generation and protecting against oxidant- or doxorubicin-induced apoptosis. The reduced reabsorption of L-Cystine in renal tubules and its poor solubility in urine are the important causes of cystine precipitation and cystine crystal formation eventually leading to kidney stones. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and cystinosis
Reference Standards   Endogenous Metabolite   Ferroptosis   ROS Kinase   Keap1-Nrf2  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W066890 4-Nitrocatechol
4-Nitrocatechol is a Lipoxygenase inhibitor. 4-Nitrocatechol can serve as a ligand to stabilize the formation of metal complexes. As a (+) MALDI matrix, 4-Nitrocatechol significantly enhances the MALDI-MS detection and imaging of low-molecular-weight compounds in animal and plant tissue sections.
Lipoxygenase   Biochemical Assay Reagents  
/
HY-P99252 Itolizumab
Itolizumab (Anti-Human CD6 Recombinant Antibody) is a humanized recombinant anti-CD6 monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19.

Species: Human

CD6  
SARS-CoV-2 Infection   Psoriasis   Rheumatoid Arthritis  
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HY-101981R Uridine 5'-monophosphate (Standard)
Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
Reference Standards   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-B0504R Creatinine (Standard)
Creatinine (Standard) is the analytical standard of Creatinine. This product is intended for research and analytical applications. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Reference Standards   Endogenous Metabolite   iGluR   GABA Receptor  
Cancer   Metabolic or Endocrine Disease  
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HY-105155 Lobradimil
Lobradimil (RMP 7), a synthetic bradykinin analog, is a potent and selective bradykinin B2 receptor agonist (Ki: 0.54 nM). Lobradimil increases the permeability of the BBB. Lobradimil can be used in the research of brain tumors.
Bradykinin Receptor  
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HY-P990083 Tegoprubart
Tegoprubart (AT-1501) is a CD40 ligand inhibitor (EC50=100 ng/mL) and immunosuppressant that selectively inhibits the CD40 ligand, a co-stimulatory molecule involved in T cell activation. Tegoprubart suppresses immune rejection, prevents rejection in animal transplantation models, and reduces cell-mediated and antibody-mediated immune responses to create a more immunotolerant environment. Tegoprubart preserves renal function when combined with Mycophenolate (HY-B0421) and Corticosteroids, and maintains graft function in preclinical studies. Tegoprubart is applicable to research related to kidney transplantation and kidney transplant rejection.

Species: Human

TNF Receptor  
Autoimmune Disease  
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HY-A0181S1 Adenosine monophosphate-15N5 dilithium
Adenosine monophosphate-15N5 dilithium is the 15N labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
Isotope-Labeled Compounds   Endogenous Metabolite   Adenosine Receptor   HSV  
Infection   Metabolic or Endocrine Disease  
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HY-W017018S2 L-Ornithine-1,2,3,4,5-13C5 hydrochloride
L-Ornithine-1,2,3,4,5-13C5 hydrochloride is the 13C-labeled L-Ornithine hydrochloride (HY-W017018). L-Ornithine hydrochloride is an orally active CaSR and p38 activator. L-Ornithine hydrochloride inhibits ROS and supports urea cycle function. L-Ornithine hydrochloride can be used to study kidney diseases involving proximal tubular cell damage caused by oxidative stress or crystallopathy, as well as research related to anxiety disorders.
Isotope-Labeled Compounds   CaSR   p38 MAPK   Reactive Oxygen Species (ROS)  
Urogenital Disease   Anxiety or Fear-Related Disease  
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HY-B0504S2 Creatinine-d5
Creatinine-d5 is the deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Metabolic or Endocrine Disease  
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HY-D1781 NTPAN-MI
NTPAN-MI is a fluorescent probe (excitation wavelength: 405 nm). NTPAN-MI is selectively activated after labeling unfolded proteins with exposed thiols, thereby reporting the degree of protein homeostasis.
Fluorescent Dye  
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HY-P99471 Bepranemab
Bepranemab is a humanized IgG4 monoclonal antibody that binds to the central region of tau protein. Bepranemab inhibits the seeding, aggregation of pathological tau protein and the spread of tau pathology to distal brain regions. Bepranemab is applicable to research related to Alzheimer's disease.

Species: Human

Tau Protein  
Alzheimer's Disease  
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HY-150097 Recombinant Human Serum Albumin(rHSA)
Recombinant Human Serum Albumin (rHSA) is a non-glycosylated monomeric plasma protein that acts as a core factor for maintaining plasma colloid osmotic pressure. Recombinant Human Serum Albumin (rHSA) possesses multiple physiological functions including carrier, metabolic regulation, detoxification, antioxidation and enzyme mimicking. Recombinant Human Serum Albumin (rHSA) not only scavenges reactive oxygen and nitrogen species via specific residues and binds a variety of endogenous and exogenous compounds to maintain redox homeostasis, but also serves as a biomarker for multiple diseases such as cancer and inflammation. Recombinant Human Serum Albumin (rHSA) broadly supports the development of implantable materials, surgical adhesives and ligand capture, and can be used for research on critical illnesses including hypovolemia, liver failure, severe sepsis and various types of trauma resuscitation.
Biochemical Assay Reagents  
Cancer   Inflammation or Immune System Disease   Liver Failure  
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HY-W015854 Ethyl methanesulfonate
Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc.
Biochemical Assay Reagents   Apoptosis   DNA Alkylator/Crosslinker  
Cancer   Neurological, Eye or Ear Disease  
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HY-B1203 Fludrocortisone
Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
Mineralocorticoid Receptor   Glucocorticoid Receptor   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Small Cell Lung Cancer  
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HY-132809 Baxdrostat
Baxdrostat is a aldosterone synthase inhibitor.
Mineralocorticoid Receptor  
Metabolic or Endocrine Disease  
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HY-P99152 Muromonab
Muromonab (Muromonab-CD3; OKT3) is a mouse monoclonal antibody targeting the CD3 antigen. Muromonab specifically binds to the CD3 antigen on the surface of human and higher primate T cells. Muromonab blocks the function of T cell receptors to recognize foreign antigens and inhibits T cell-mediated immune responses, including cell-mediated lymphocyte lysis and T cell proliferation responses. Muromonab can be used to study acute kidney, liver, heart and combined kidney-pancreas transplant rejection, and can also be used to study graft-versus-host disease in bone marrow transplant patients.

Species: Human

CD3   IFNAR   Interleukin Related  
Inflammation or Immune System Disease   Leukemia/Lymphoma/Myeloma  
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HY-P1070A Amylin, amide, human TFA
Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human TFA inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.
Amylin Receptor  
Metabolic or Endocrine Disease  
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HY-109017 Vamorolone
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
Glucocorticoid Receptor   Mineralocorticoid Receptor   NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
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HY-B1770 Sodium Iodide,99%
Sodium Iodide is a compound composed of sodium ions and iodine ions. Sodium Iodide scavenges hydrogen peroxide. Sodium Iodide maintains the level of thyroid hormone T3 through its iodine component. Sodium Iodide protects tissues from oxidative damage and regulates thyroid homeostasis. Sodium Iodide relieves acute myocardial infarction.
Environmental Pollutants   Biochemical Assay Reagents  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-129047A Trypsin (MS grade)
Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation.
Ser/Thr Protease   Protease Activated Receptor (PAR)  
Inflammation or Immune System Disease  
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HY-P1070 Amylin, amide, human
Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.
Amylin Receptor  
Metabolic or Endocrine Disease  
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HY-P73267 Kininogen-1 Protein, Mouse (HEK293, His)
Together with endopeptidase inhibitor, protease, and signaling receptor binding activities, the Kininogen-1 protein is predicted to play a critical role in antimicrobial response, coagulation regulation, and control of endopeptidase activity.Kininogen-1 is located in the collagen-containing matrix and shows biased expression, particularly in the liver at embryonic (E18) and adult stages (RPKM 646.0 and 179.1).Kininogen-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Kininogen-1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Protease Inhibitors Cystatin Family Kininogen-1

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HY-P7195 HCC-1/CCL14 Protein, Human
HCC-1/CCL14 Protein, Human is a CC chemokine with weak activity against human monocytes, promotes monocyte, eosinophil and T-lymphocyte chemotaxis, and mediates allergic airway inflammation and cancer. HCC-1/CCL14 Protein, Human is a recombinant human HCC-1/CCL14(T22-N93) expressed by E. coli.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL14

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HY-P72163 CYP11B2 Protein, Human (His-SUMO)
CYP11B2 Protein, a cytochrome P450 monooxygenase, synthesizes aldosterone, pivotal for salt and water balance, impacting blood pressure and cardiovascular health. Mechanistically, it orchestrates three oxidative reactions, forming aldosterone, utilizing molecular oxygen and a mitochondrial transfer system. Additionally, CYP11B2 may be involved in the androgen metabolic pathway, expanding its physiological roles. CYP11B2 Protein, Human (His-SUMO) is the recombinant human-derived CYP11B2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P73266 Kininogen-1 Protein, Human (626a.a, HEK293, His)
Kininogen-1 protein undergoes alternative splicing, producing high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for coagulation, assembly of the kallikrein-kinin system, and release of the antimicrobial bradykinin. Kininogen-1 Protein, Human (626a.a, HEK293, His) is the recombinant human-derived Kininogen-1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Protease Inhibitors Cystatin Family Kininogen-1

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HY-P70956 Kininogen-1 Protein, Human (409a.a, HEK293, His)
Kininogen-1 is a key regulator in the coagulation process, inhibiting thiol proteases and strategically targeting prekallikrein and factor XI for coagulation regulation. HMW-kininogen prevents thrombin and plasmin-induced platelet aggregation and aids in hemostasis. Kininogen-1 Protein, Human (409a.a, HEK293, His) is the recombinant human-derived Kininogen-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Protease Inhibitors Cystatin Family Kininogen-1

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HY-P7197 HCC-4/CCL16 Protein, Human
HCC-4/CCL16 Protein, Human is a CC chemokine that specifically attracts lymphocytes, dendritic cells and monocytes, increases their adhesion and has myelosuppressive activity. HCC-4/CCL16 Protein, Human interacts with CCR1, CCR2, CCR5 and CCR8 to mediate inflammatory and cancer responses. HCC-4/CCL16 Protein, Human is a recombinant human HCC-4/CCL16 (Q24-Q120) expressed by E. coli.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL16

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HY-P72264 TPM2 Protein, Human (His)
The TPM2 protein binds actin filaments in muscle and nonmuscle cells and centrally regulates calcium-dependent striated muscle contraction in vertebrates, particularly in concert with the troponin complex. In smooth muscle cells, TPM2 helps regulate contraction by interacting with calcium-binding proteins. TPM2 Protein, Human (His) is the recombinant human-derived TPM2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P75149 HCC-1/CCL14 Protein, Human (66a.a, His)
HCC-1/CCL14 Protein, Human (66a.a, His) is a CC chemokine with weak activity against human monocytes, promotes monocyte, eosinophil and T-lymphocyte chemotaxis, and mediates allergic airway inflammation and cancer. HCC-1/CCL14 Protein, Human (66a.a, His) is a recombinant human HCC-1/CCL14 (G28-N93) expressed by E. coli with a his tag at the nitrogen end.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL14

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HY-P75316 CUTC Protein, Human (His)
CUTC proteins potentially regulate copper homeostasis by binding Cu(1+) of each subunit, suggesting a role in the control of cellular copper levels. As a homotetramer, the tetrameric arrangement of CUTC suggests cooperative behavior in managing copper ions. CUTC Protein, Human (His) is the recombinant human-derived CUTC protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

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HY-P703351 CHT Protein, Human (HEK293, Strep, His)
CHT Protein, Human (HEK293, Strep, His) is the recombinant human-derived CHT, expressed by HEK293 , with Strep, His labeled tag.

Species: Human; Source: HEK293

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HY-P75148 HCC-1/CCL14 Protein, Human (74a.a, His)
HCC-1/CCL14 Protein, Human (74a.a, His) is a CC chemokine with weak activity against human monocytes, promotes monocyte, eosinophil and T-lymphocyte chemotaxis, and mediates allergic airway inflammation and cancer. HCC-1/CCL14 Protein, Human (74a.a, His) is a recombinant human HCC-1/CCL14(T20-N93) expressed by E. coli with a his tag at the nitrogen end.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL14

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HY-P703215 SLC12A3 Protein, Human (HEK293, His, MBP, Flag)
SLC12A3 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC12A3, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

Species: Human; Source: HEK293

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HY-P701903 Dit Protein, Bacillus phage SPP1
The Dit protein is an important component that forms a 40 Å wide channel distal to the tail in its homohexameric structure. This unique channel structure plays a crucial role in cellular processes and may facilitate DNA ejection. Dit Protein, Bacillus phage SPP1 is the recombinant Dit protein, expressed by E. coli , with tag free.

Species: Others; Source: E. coli

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HY-P701904 Dit Protein, Bacillus phage SPP1 (FLAG, His)
The Dit protein is an important component that forms a 40 Å wide channel distal to the tail in its homohexameric structure. This unique channel structure plays a crucial role in cellular processes and may facilitate DNA ejection. Dit Protein, Bacillus phage SPP1 (FLAG, His) is the recombinant Dit protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.

Species: Others; Source: E. coli

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HY-P704781 MCP-4/CCL13 Protein, Human (His)
MCP-4/CCL13 Protein, Human (His) is the recombinant human-derived MCP-4/CCL13 protein, expressed by E. coli, with N-His tag.

Species: Human; Source: E. coli

Cytokines and Growth Factors Chemokine & Receptors CC Chemokines CCL13

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HY-P81204 Alpha-ENaC Antibody
Alpha-ENaC Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Alpha-ENaC.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82597 DLX5 Antibody (YA2342)
DLX5 Antibody (YA2342) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DLX5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87094 Slow Skeletal Myosin Heavy chain Antibody (YA6787)
Slow Skeletal Myosin Heavy chain Antibody (YA6787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Slow Skeletal Myosin Heavy chain.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82395 Kininogen 1 Antibody (YA2140)
Kininogen 1 Antibody (YA2140) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kininogen 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86853 Dlx2 Antibody (YA6546)
Dlx2 Antibody (YA6546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dlx2.

Host: Rabbit; Reactivity: Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810354 DLX3 Antibody (YA9676)
DLX3 Antibody (YA9676) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to DLX3.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83062 CLIC1 Antibody (YA2807)
CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83062A CLIC1 Antibody (YA2807)(PBS only)
CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P88000 TrpV5 Antibody (YA7685)
TrpV5 Antibody (YA7685) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P88155 DLX1 Antibody (YA7839)
DLX1 Antibody (YA7839) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DLX1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P88155A DLX1 Antibody (YA7839)(PBS only)
DLX1 Antibody (YA7839) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DLX1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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Keywords

kidney function | electrolyte balance | blood pressure regulation | renal ion transport | sodium homeostasis | potassium homeostasis | pressure natriuresis | renin-angiotensin-aldosterone system | RAAS | aldosterone | epithelial sodium channel | ENaC | sodium-chloride cotransporter | NCC | distal nephron | salt-sensitive hypertension | renal sodium reabsorption | bradykinin | renal tubular transport