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Diffusion MRI and Microstructure

Neurodegeneration Cellular Degeneration Chronic Inflammation

Diffusion magnetic resonance imaging (dMRI) is a noninvasive imaging approach that probes tissue microstructure through the micron-scale displacement of water molecules, providing measures related to microstructural integrity and complexity, axonal order and density, and myelination. Diffusion-weighted approaches developed into diffusion tensor imaging (DTI), which became widely used in clinical and research settings for evaluating brain microstructure and white-matter organization. However, the tensor representation has important limitations because fractional anisotropy reflects both microscopic diffusion anisotropy and fiber orientation dispersion, complicating its interpretation as a marker of tissue integrity in regions with complex architecture. Advanced approaches-including diffusion kurtosis imaging (DKI), neurite orientation dispersion and density imaging (NODDI), free-water imaging, and microscopic anisotropy measurements-were developed to characterize tissue properties that conventional DTI cannot separate. This progression has made diffusion MRI an important framework for investigating neurological disease and candidate imaging biomarkers. The biological information obtained from diffusion MRI arises from restrictions and directional variation in water diffusion imposed by tissue microstructure rather than from activation or inhibition of a molecular signaling pathway[1][2][3].

DTI-derived fractional anisotropy is sensitive to anisotropic cellular structures such as axons but is also influenced by their orientation dispersion, whereas microscopic fractional anisotropy can separate microscopic anisotropy from orientation coherence. NODDI further partitions diffusion behavior into microstructural indices including neurite density and orientation dispersion. In a mouse model of human tauopathy, NODDI neurite density correlated with histological hyperphosphorylated tau levels, while lower DTI fractional anisotropy and higher NODDI orientation dispersion occurred in corpus callosum white matter; NODDI measures correlated more closely with histological tau pathology than DTI measures. In multiple sclerosis, advanced diffusion measurements identified changes from normal-appearing white matter through perilesional tissue to lesions, consistent with decreased tissue restriction and axonal density and increased DTI diffusivity. These findings illustrate how diffusion compartment modeling can connect water mobility with axonal organization, neurite density, tissue restriction, and pathological microstructural change. Disease applications now extend across neurodegeneration, cerebrovascular disease, tumors, spinal-cord imaging, and biomarker-oriented research[3][4][5].

In young-onset Alzheimer’s disease, superficial white matter showed lower neurite density and higher orientation dispersion, separating degenerative and organizational changes that standard tensor metrics could not distinguish. In cerebral small-vessel disease, multi-shell DKI metrics showed strong associations with processing speed and excellent reproducibility, supporting diffusion metrics as research and clinical-care markers. Brain-tumor studies demonstrated that microscopic fractional anisotropy can distinguish orientation dispersion from microscopic anisotropy, while spinal-cord studies showed that DTI and microstructural models are sensitive to multiple tissue features but may lack the biological specificity implied by their model parameters. This limitation defines a central research gap: diffusion-derived parameters can be sensitive to pathology without uniquely identifying the underlying tissue feature. Future work therefore requires histological validation, biologically appropriate model assumptions, robust parameter estimation, reproducible acquisition, and disease-specific interpretation before microstructural diffusion MRI can provide reliable individual-level biomarkers for diagnosis, disease progression, and therapeutic evaluation.[1][3][6][7][8].

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Cat. No. Product Name Information Application Publication
HY-L068 Flavonoids Library
Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc. MCE offers a unique collection of 583 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Structure Classified Natural Product Libraries

98
HY-L028 CNS-Penetrant Compound Library
The blood-brain barrier (BBB) is the complex network of brain microvessels. It protects the brain from the external bloodstream environment and supplies the brain with the required nutrients for normal function. However, blood-brain barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases or brain tumors, as it has the least permeable capillaries in the entire body due to physical barriers (tight junctions). Therefore, it is crucial to discover drugs which can cross this barrier for the treatment of brain-based diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and epilepsy. MCE offers a unique collection of 1,170 compounds with confirmed CNS-Penetrant property. It’s a useful tool for the discovery of drugs used for brain diseases, such as brain tumors, mental disorders, and neurodegenerative diseases.

Compound Characteristic Classified Libraries

91
HY-L054 Endoplasmic Reticulum Stress Compound Library
Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer. MCE Endoplasmic Reticulum Stress Compound Library contains 379 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

Signaling Pathway Targeting Libraries

85
HY-L086 Neurodegenerative Disease-related Compound Library
Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour. MCE offers a unique collection of 3,759 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

Disease Focused Libraries

85
HY-L136 Coagulation and Anti-coagulation Compound Library
Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation. Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process. MCE supplies a unique collection of 1,525 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Signaling Pathway Targeting Libraries

85
HY-L029 Autophagy Compound Library
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 2,080 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Signaling Pathway Targeting Libraries

84
HY-L050 Ubiquitination Compound Library
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 507 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Signaling Pathway Targeting Libraries

84
HY-L060 Cytoskeleton Compound Library
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 2,313 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L069 Anti-Alzheimer's Disease Compound Library
Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc. MCE offers a unique collection of 2,174 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

Disease Focused Libraries

84
HY-L070 Neuroprotective Compound Library
Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases. MCE offers a unique collection of 1,851 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.

Compound Characteristic Classified Libraries

84
HY-L021M Natural Product and Natural Product-Like Compound Library
From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research. MCE provides a unique collection of 20,566 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).
83
HY-L105 Peptide Library
Peptides are a group of biologically active substances that are involved in various cellular functions of organisms. Peptides are often used in functional analysis, vaccine research and especially in the field of drug research and development. At present, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. MedChemExpress (MCE) offers a comprehensive collection of 2,647 peptides, including bioactive peptides, amino acid derivatives, and blocking peptides. MCE Peptide Library can be used for peptide library screening, peptide drug discovery, vaccine development, target verification, structural activity research, etc.

Structure Classified Libraries

83
HY-L105S Peptide Compound Library
Peptides, composed of amino acids, serve as crucial building blocks for proteins and have gained significant attention in drug development over the past decade. The advancements in production, modification, and analytical technologies have led to a surge in the potential applications of peptides in medicine. Peptides offer a number of advantages over small molecule drugs, including: greater target specificity and efficacy, more predictable metabolic profiles, easier delivery to where they are needed in the body, and fewer side effects. Peptides are increasingly appearing in all branches of medicine as components of innovative drugs, imaging agents, diagnostic agents, and other complex drugs such as peptide-drug conjugates. To date, more than 80 peptide drugs have been approved to treat a variety of diseases, including microbial infections, obesity, anti-diabetes, and cancer, as well as to develop cell targeting platforms and improve cell penetration properties. MCE designs a unique collection of 867 peptide compounds. HY-L105S is a peptide compound library that can be provided with solution form based on HY-L105, and can be applied to peptides-based drug development.

Structure Classified Libraries

83
HY-L166 Ion Channel Compound Library
Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na+ ), potassium (K+ ), calcium (Ca2+ ), chloride (Cl- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1,751 small molecules related to ion channel, mainly targeting Na+ channel, K+ channel, Ca2+ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Signaling Pathway Targeting Libraries

83
HY-L175 Inflammasomes related Compound Library
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L194 Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library
Heat-clearing and detoxification is a specific treatment method in the research of traditional Chinese medicine (TCM), which is clinically used to treat infectious diseases with remarkable effect. Over the past decades, the research of heat-clearing and detoxification treatment has been one of the most active fields of combining traditional Chinese and western medicines, and has made remarkable achievements. Nowadays, the application field of heat-clearing and detoxification traditional Chinese medicine is not only limited to antibacterial and antiviral, but also has made progress in the research fields of anti-inflammatory reaction, anti-endotoxin, anti-peroxidative damage, anti-inflammatory cytokines, enhancement of immune function, protection of cellular organelles, and maintenance of calcium homeostasis. In addition to this, clearing heat and removing toxins has also made significant research progress in non-infectious diseases, for example, in tumors, cardiovascular diseases, renal diseases, blood diseases, geriatrics, and diabetes, all of which have shown good curative effect. MCE can supply 1,282 monomer component from more than a hundred sources of heat-clearing and detoxification TCM, which can be used in TCM studies, drug development and mechanism-based studies.
83
HY-L223 Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library
Antitussive and antiasthmatic method is a type of treatment strategy in traditional Chinese medicine, mainly used to alleviate symptoms such as coughing and asthma. These symptoms may be caused by various factors, such as: Bronchial asthma, chronic obstructive pulmonary disease, asthmatic bronchitis, cough-induced asthma, and others. Based on existing research in traditional Chinese medicine, many types of Chinese medicinal herbs showed antitussive and antiasthmatic effects. For example: Ardisiae Japonicae Herba, Ginkgo Semen, Amygdalus Communis Vas, Farfarae Flos, Viticis Cannabifoliae Fructus, Eriobotryae Folium etc. Therefore, the active ingredients derived from these traditional Chinese medicine have high medicinal value and have the potential to be developed into drugs for related diseases. MCE can provide 861 active ingredients that can be obtained from traditional Chinese medicine with antitussive and antiasthmatic functions, which can be applied to drug development and research on disease mechanisms.

Traditional Chinese Medicine Libraries

83
HY-L242 Flavors and Fragrances Compound Library
Flavors and fragrances serve as indispensable enhancing elements in modern industries, playing multidimensional roles in the fields of food, cosmetics, and pharmaceutical development. In the food industry, flavors and fragrances are not only used to compensate for flavor loss during processing but also to create novel sensory experiences and enhance product appeal. Natural flavors such as vanilla and citrus oils impart rich, layered aromas to foods, while synthetic flavors can precisely replicate specific tastes, meeting the demands of standardized production and extending the flavor stability of food products. In the cosmetics sector, flavors and fragrances are key to emotional design. They enhance product recognition and elevate the pleasure of use through pleasant scents. In pharmaceutical development, the application of flavors and fragrances focuses on improving compliance. Especially in formulations such as oral liquids and chewable tablets, the addition of mint, fruit, and other flavoring components effectively masks the bitter or irritating taste of medications, increasing patient acceptance. Additionally, some natural flavors may themselves possess auxiliary therapeutic benefits. MCE contains 495 kinds of flavors and fragrances, which can be used in fields such as food, cosmetics and drug development.

Compound Characteristic Classified Libraries

83
HY-L919 MCE CNS BBB Lead-like Library
With the aging population and increasing competitive pressures, neurodegenerative diseases of the central nervous system (CNS) have become a serious medical challenge in modern society, including Parkinson's disease, Alzheimer's disease, brain tumors, and multiple sclerosis. However, the success rate of CNS drug development remains remarkably low, primarily due to the blood-brain barrier (BBB). The blood-brain barrier (BBB) is a semipermeable barrier structure that surrounds the microvasculature of the CNS. In capillaries, the wedged endothelial cells are tightly packed and wedge-shaped, lining the interior of the vessels to form extensive tight junctions. Along with a range of receptors, transporters, efflux pumps, and other cellular components, this barrier regulates the entry and exit of molecules between the bloodstream and the brain. The intact BBB blocks the passage of most blood-borne substances into the brain, preventing nearly 100% of large-molecule drugs and over 98% of small-molecule drugs from entering. Compared to non-CNS drugs, physicochemical properties such as hydrogen bonds, lipophilicity, and molecular weight significantly influence a compound's ability to cross the BBB. Using artificial intelligence (AI) algorithms to predict BBB permeability, a predicted value greater than 0.75 indicates that the compound has strong potential to cross the BBB, providing a promising starting point for CNS drug discovery.

Focused and target libraries

83
HY-L920 CNS MPO Lead-like Library
With the aging population and increasing competitive pressures, neurodegenerative diseases of the central nervous system (CNS) have become a serious medical challenge in modern society, including Parkinson's disease, Alzheimer's disease, brain tumors, and multiple sclerosis. The CNS MPO (Multi-Parameter Optimization) score is a widely recognized algorithm in medicinal chemistry. Developed by Pfizer, this method is based on an analysis of approved CNS drugs and their interior CNS drug candidates, establishing the CNS MPO rules. It incorporates six key physicochemical properties (ClogP, ClogD, MW, TPSA, HBD, and pKa) to prospectively optimize CNS drug attributes—such as high blood-brain barrier (BBB) permeability, low P-gp efflux liability, low metabolic clearance, and high safety—thereby improving the clinical success rate of CNS drug candidates. The CNS MPO compound library is a collection of compounds with CNS MPO scores greater than 5, specifically designed for CNS drug discovery.

Focused and target libraries

83
HY-L949 Spirocyclic Privileged Scaffold Lead-like Library
Spirocyclic compounds, with rigid 3D structures, high Fsp³ and strong conformational restriction, are highly privileged scaffolds in small-molecule drug screening. They overcome drawbacks of planar aromatic compounds such as poor solubility, high off-target risks and weak druggability. Their orthogonal bicyclic geometry fits well into protein pockets, improving target affinity, subtype selectivity, metabolic stability and membrane permeability, making them ideal for hit identification against kinases, GPCRs, PPIs and other targets. Spirocyclic scaffolds have been widely applied in oncology, antivirals, hypertension and CNS diseases, leading to many approved drugs and clinical candidates. SAR studies show that spiro-atom chirality, ring size and heteroatom substitution dominate bioactivity and selectivity, with the scaffold mainly serving as a conformational anchor. Azaspirocycles, spirooxindoles and spirosteranes target GPCRs, kinases, MDM2-p53 and PPIs. Approved drugs including irbesartan, spironolactone and rolapitant confirm their druggability, while revumenib and SAR405838 show promise against undruggable targets. The MCE Spirocyclic Druglike Library contains over 1,000 diverse, stereospecific molecules selected by Lipinski’s rules. It covers privileged cores such as azaspirocycles, oxaspirocycles and spirooxindoles. These molecules bear rich chiral centers and distinct 3D orientations, reducing non-specific binding and enhancing screening efficiency. Featuring novel scaffolds, the library offers a highly innovative starting point for drug discovery.

According to Lead-like Structures

83
HY-17363 Dimethyl fumarate
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.
Keap1-Nrf2   Reactive Oxygen Species (ROS)   HIV   Autophagy   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Colorectal Cancer   Viral Infection   Obesity   Lung Fibrosis  
65
HY-K2005 High Sensitivity ECL Kit

High Sensitivity ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems. The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Electrophoresis & WB Chemiluminescent Detection

32
HY-K1047 AntiFade Mounting Medium (with DAPI)

Anti-Fade Mounting Medium (with DAPI) is a mounting reagent designed to retard fluorescence photobleaching and preserve signal intensity during long-term imaging. For immediate observation of samples, please select HY-K1048, a non-solidifying anti-fade mounting medium with DAPI. The 5 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Analysis AntiFade Mounting Medium

22
HY-15136 Lonafarnib
Lonafarnib (Sch66336) is an orally active, blood-brain barrier penetrant farnesyltransferase (FPTase) inhibitor. Lonafarnib increases the phosphorylation levels of Akt, CaMKII and CREB, upregulates BDNF expression in the hippocampus, elevates the content of α7nAChR on cell membranes, and blocks the isoprenylation of H-Ras. Lonafarnib repairs synapses and reverses spatial memory deficits in Aβ1-42 model mice. Lonafarnib inhibits RSV fusion and replication, and alleviates virus-induced lung injury. Lonafarnib activates the lysosomal and autophagic pathways, and reduces the phosphorylation and aggregation of tau. Lonafarnib acts synergistically with Sorafenib (HY-10201) to promote apoptosis, and inhibits the proliferation and invasion of melanoma cells. Lonafarnib inhibits the farnesylation of progerin, repairs nuclear membrane defects, and activates the cGAS-STING-STAT1 signaling pathway. Lonafarnib can be used in research related to diseases including Alzheimer's disease, viral infections, melanoma, and progeria.
Farnesyl Transferase   Tau Protein   RSV   Akt   Ras   Bcl-2 Family   STAT   nAChR   Apoptosis   Autophagy  
Melanoma   Viral Infection   Alzheimer's Disease  
14
HY-W015229 3-Indolepropionic acid
3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Endogenous Metabolite   Reactive Oxygen Species (ROS)  
Glucose Metabolism   Alzheimer's Disease  
13
HY-N0127 Yohimbine Hydrochloride
Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
Adrenergic Receptor  
Depression   Glucose Metabolism   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension  
11
HY-K2006 Sensitive ECL Kit

Sensitive ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems. The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Protein Biology Protein Electrophoresis & WB Chemiluminescent Detection

8
HY-139414 Lysophosphatidylcholines
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.
Interleukin Related   p38 MAPK   ERK   Apoptosis  
Inflammation or Immune System Disease  
7
HY-19948 Leucomethylene blue mesylate
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes.
Tau Protein  
Neurological, Eye or Ear Disease  
6
HY-D0722 5(6)-CFDA
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes.
Fluorescent Dye  
6
HY-18743 Coelenterazine
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).

Source: marine bioluminescent organisms

Reactive Oxygen Species (ROS)  
Cancer  
6
HY-K0246 Anti-GFP Magnetic Agarose Beads

MCE Anti-GFP Magnetic Agarose Beads can be used for the detection and purification of GFP, EGFP, and their fusion-expressed proteins and IP assays.

Protein Biology Protein Purification Magnetic Agarose Beads

6
HY-P99188 Carlumab
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds and neutralises profibrotic activities of human CCL2. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvascular density. Carlumab can be used for the research of cancer, suah as prostate cancer.

Species: Human

CCR  
Prostate Cancer  
5
HY-B1028 Pantethine
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration.
Endogenous Metabolite   SARS-CoV  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Ovarian Cancer   Viral Infection   Cardiovascular Disease   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease  
5
HY-W040821 DL-Homocysteine
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
4
HY-NP013 Oxidized low density lipoprotein (mouse)
Oxidized low density lipoprotein (mouse) (Mouse ox-LDL) is an oxidized low density lipoprotein (LDL). Oxidized low density lipoprotein (mouse) induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration. Oxidized low density lipoprotein (mouse) can be used to construct an in vitro model of AS.
LDLR   ROR   β-catenin  
Blood or Cardio-cerebrovascular Disease  
4
HY-K0237 Anti-HA Magnetic Agarose Beads

MCE Anti-HA Magnetic Agarose Beads can be used for the detection and purification of HA fusion-expressed proteins and IP assays.

Protein Biology Protein Purification Magnetic Agarose Beads

4
HY-D1080 EDANS
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET).
Fluorescent Dye  
3
HY-D0047 5-CFDA
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes.
Fluorescent Dye  
3
HY-W004284 Heptadecanoic acid
Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis.
Apoptosis   Akt   PI3K  
Pancreatic Cancer   Cardiovascular Disease   Glucose Metabolism   Multiple Sclerosis  
3
HY-D0837 Imidazole
Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
MOFs   Ser/Thr Protease   Thrombopoietin Receptor  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   SARS-CoV-2 Infection  
3
HY-K0225 Carboxyl Magnetic Beads (200 nm, 10 mg/mL)

MCE Carboxyl Magnetic beads (200 nm, 10 mg/mL) are characterized by superparamagnetism, fast magnetic response, abundant carboxyl functional groups, monodispersity, and submicron scale particle size. Biological ligands (proteins, peptides, oligonucleotides, drug molecules, etc.) can be covalently coupled to the surface of microspheres under the action of special chemical reagents (such as EDC).

Protein Biology Protein Purification Magnetic Beads

3
HY-K0236 Anti-Flag Magnetic Agarose Beads

MCE Anti-GFP Magnetic Agarose Beads can be used for the detection and purification of Flag (DYKDDDDK) fusion-expressed proteins and IP assays.

Protein Biology Protein Purification Magnetic Agarose Beads

3
HY-P3252AS Pegcetacoplan-13C3,15N TFA
Pegcetacoplan-13C3,15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
Isotope-Labeled Compounds   Complement System  
Inflammation or Immune System Disease  
2
HY-P1387 β-Amyloid (1-40) (rat)
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease.
Amyloid-β   Apoptosis  
Neurological, Eye or Ear Disease  
2
HY-P0097 Nonapeptide-1
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.
Melanocortin Receptor  
Cancer   Metabolic or Endocrine Disease  
2
HY-N0450 Sinapine thiocyanate
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
P-glycoprotein   Cholinesterase (ChE)  
Ovarian Cancer   Alzheimer's Disease   Parkinson's Disease  
2
HY-172286 Cy7 NHS ester
Cy7 NHS ester is a fluorescent dye that can be used for fluorescent imaging study.
Fluorescent Dye  
2
HY-P0097A Nonapeptide-1 acetate salt
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.
Melanocortin Receptor  
Cancer   Metabolic or Endocrine Disease  
2
HY-101184 T807
T807 a novel tau positron emission tomography (PET) tracer.
Tau Protein  
Viral Infection   SARS-CoV-2 Infection   Alzheimer's Disease  
2
HY-N5077 Sinapine
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
Cholinesterase (ChE)   P-glycoprotein  
Inflammation or Immune System Disease   Ovarian Cancer   Alzheimer's Disease   Parkinson's Disease  
2
HY-122704A Surfen dihydrochloride
Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen dihydrochloride inhibits HSV-1 viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE.
FGFR   HSV   Tau Protein  
Inflammation or Immune System Disease   Lung Cancer   Prostate Cancer   Liver Cancer   Viral Infection   Neurodegenerative Disease  
2
HY-10863 Anandamide
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis.
Cannabinoid Receptor   PPAR   TRP Channel   GPR55   Fungal   Tau Protein   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
2
HY-P71213 Pleiotrophin Protein, Mouse (HEK293, His)
Pleiotrophin (PTN) is a secreted growth factor that transduces signals through cell surface proteoglycan and non-proteoglycan receptors.PTN binds to chondroitin sulfate (CS) groups and regulates cell proliferation, survival, and differentiation, particularly inhibiting long-term synaptic potentiation of neurons.Pleiotrophin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Pleiotrophin protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors

2
HY-P700138AF Animal-Free MDK Protein, Human (His)
Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. Animal-Free MDK Protein, Human (His) is the recombinant human-derived animal-FreeMDK protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Species: Human; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins

2
HY-P1043 NGR peptide
NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging.
Aminopeptidase  
Cancer  
1
HY-W040074 Glycylglycine hydrochloride hydrate
Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
1
HY-D1464A CH1055 triethylamine
CH1055 triethylamine is a near-infrared II (NIR-II) fluorescent dye that can be used as a fluorescent probe for in vivo imaging. CH1055 triethylamine can be conjugated with antibodies or ligands for specific imaging (for example the tumor imaging).
Fluorescent Dye  
Cancer  
1
HY-P6083 RTSPSSR
RTSPSSR is synthesized peptide, which binds specifically to claudin-1 and visulizes the CRC tumor in mice, through near-infrared fluorescence imaging.
Biochemical Assay Reagents  
1
HY-P99891 Rovelizumab
Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke.

Species: Human

Integrin  
Blood or Cardio-cerebrovascular Disease  
1
HY-D1464 CH1055
CH1055 is a near-infrared II (NIR-II) fluorescent dye that can be used as a fluorescent probe for in vivo imaging. CH1055 can be conjugated with antibodies or ligands for specific imaging (for example the tumor imaging).
Fluorescent Dye  
Cancer  
1
HY-P99524 Vatelizumab
Vatelizumab (GBR500) is a monoclonal antibody that targets the α2 subunit (CD49b) of very late antigen 2 (VLA-2). Vatelizumab can be used for research on multiple sclerosis.

Species: Human

Integrin  
Multiple Sclerosis  
1
HY-W009300 4-Hydroxyestrone
4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
Endogenous Metabolite   Estrogen Receptor/ERR   Sirtuin   MDM-2/p53   PDI   Ferroptosis   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-Y0395 3-Carboxyphenylboronic acid
3-Carboxyphenylboronic acid is a biochemical reagent with multiple functions including nanoparticle enhancement, perovskite passivation, fluorescence quenching, and adhesion. 3-Carboxyphenylboronic acid improves tumor penetration and pulmonary retention of nanoparticles, and serves as a tumor-targeting ligand for carboxymethyl chitosan nanoparticles. 3-Carboxyphenylboronic acid optimizes film crystallization via coordinate chelation of free lead/iodide ions in perovskites. 3-Carboxyphenylboronic acid acts as an additive for n-i-p perovskite solar cells. Conjugation of 3-Carboxyphenylboronic acid with PPEG8 quenches the near-infrared fluorescence of single-walled carbon nanotubes, enabling aqueous dispersion of carbon nanotubes through binding to the diol structure of saccharides.
Biochemical Assay Reagents  
1
HY-P1043A NGR peptide Trifluoroacetate
NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging.
Aminopeptidase  
Cancer  
1
HY-N10574A Queuine dihydrochloride
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells.

Source: eubacteria

Others  
Metabolic or Endocrine Disease  
1
HY-122381 Kyotorphin
Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients.
Bacterial   Endogenous Metabolite  
Bacterial Infection   Alzheimer's Disease  
1
HY-106353 Smilagenin
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.
mAChR   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
1
HY-126415 Magnesium Lithospermate B
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration.
Na+/K+ ATPase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Cardiovascular Disease  
1
HY-128700 Nicotinic acid mononucleotide
Nicotinic acid mononucleotide acts as a SARM1 inhibitor and a NAD+ biosynthesis intermediate, with an IC50 value of 93.3 μM against SARM1. Nicotinic acid mononucleotide exerts axon-protective effects, delays axonal degeneration, elevates NAD+ levels, enhances Sirt1 activity, improves myocardial capillary density and alleviates myocardial fibrosis. Nicotinic acid mononucleotide reverses diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD+ levels. Nicotinic acid mononucleotide is applicable to research related to cancer, multiple sclerosis, diabetic cardiomyopathy, neurodegenerative diseases and Huntington's disease.
Endogenous Metabolite   Sirtuin  
Cancer   Huntington's Disease   Multiple Sclerosis  
1
HY-P1363F3 5-FAM-β-Amyloid (1-42), human Tris
5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) Tris is a 5-FAM labeled β-Amyloid (1-42), human. β-Amyloid (1-42), human is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome.
Amyloid-β  
Alzheimer's Disease  
1
HY-D0889 Glycylglycine
Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).
Endogenous Metabolite  
Neurodegenerative Disease   Male Reproductive System Disease  
1
HY-N10574 Queuine
Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells.

Source: eubacteria

Bacterial  
Metabolic or Endocrine Disease  
1
HY-111263 NIAD-4
NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM.
Fluorescent Dye   Amyloid-β  
1
HY-P10368 P110 heptapeptide
P110 heptapeptide is a peptide inhibitor of the Drp1-Fis1 interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of Drp1, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases.
Dynamin   Reactive Oxygen Species (ROS)  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
1
HY-P99113 Inebilizumab
Inebilizumab is an anti-CD19 monoclonal antibody (mAb) with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used for multiple sclerosis and neuromyelitis optica research.

Species: Human

ADC Antibodies   CD19  
Myasthenia gravis   Multiple Sclerosis  
1
HY-P79419 MDK/Midkine Protein, Mouse
Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration. MDK/Midkine Protein, Mouse is the recombinant mouse-derived Midkine protein, expressed by E. coli , with tag free.

Species: Mouse; Source: E. coli

1
HY-P700791 MDK/Midkine Protein, Human (His-Avi)
Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. MDK/Midkine Protein, Human (His-Avi) is the recombinant human-derived MDK/Midkine protein, expressed by E. coli , with C-Avi, N-His labeled tag.

Species: Human; Source: E. coli

Cytokines and Growth Factors

1
HY-P73295 MDK/Midkine Protein, Human (sf9)
Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. MDK/Midkine Protein, Human (sf9) is the recombinant human-derived MDK protein, expressed by Sf9 insect cells , with tag free.

Species: Human; Source: Sf9 insect cells

Cytokines and Growth Factors

1
HY-P700223AF Animal-Free Midkine Protein, Mouse (His)
Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors.It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration.Animal-Free Midkine Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMidkine protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins

1
HY-K0200A Magnetic Stand Plus

MCE Magnetic Stand Plus features an upgraded design that is compatible with multiple centrifuge tube formats, including 200 μL, 1.5 mL, 2 mL, 5 mL, 10 mL, and 15 mL tubes. It adopts a detachable strong magnetic block design, allowing flexible operation for samples of different volumes and improving both convenience and separation efficiency during experiments.

Protein Biology Protein Purification Magnetic Stand

1
HY-W008048S 2',3'-O-Isopropylideneadenosine-13C5
2',3'-O-Isopropylideneadenosine-13C5 is the 13C-labeled 2',3'-O-Isopropylideneadenosine (HY-W008048). 2',3'-O-Isopropylideneadenosine is a nucleoside compound and also a Golgi-targeting moiety. 2',3'-O-Isopropylideneadenosine constitutes a furanose ribose group that undergoes cyclization at the O (2') and O (3') atoms. As a component of the fluorescent probe TPE-Ade, 2',3'-O-Isopropylideneadenosine enables specific Golgi localization for fluorescence imaging. 2',3'-O-Isopropylideneadenosine participates in the synthesis of aggregation-induced emission (AIE) fluorescent probes.
Isotope-Labeled Compounds   Nucleoside Antimetabolite/Analog  
/
HY-181696 EC0652
EC0652 is a PSMA imaging agent with SPECT imaging capability. EC0652 can be used for the research of metastatic castration-resistant prostate cancer.
PSMA  
Prostate Cancer  
/
HY-P99691 Lemalesomab
Lemalesomab (IMMU-MN3) is a Fab' fragment of a murine anti-granulocyte monoclonal antibody targeting NCA-90 (CEACAM6). Lemalesomab binds strongly to NCA-90 on the surface of granulocytes, cross-reacts with epitopes of other CEA family members, and blocks the binding between human colon adenocarcinoma cells and CEA. When labeled with 99mTc, Lemalesomab can be used for radionuclide imaging of soft tissue infections and osteomyelitis.

Species: Human

Transmembrane Glycoprotein  
Infection   Inflammation or Immune System Disease   Arthritis  
/
HY-184075S Nomelcitinib
Nomelcitinib is a TYK2 inhibitor that modulates the IL23 signaling pathway. Nomelcitinib is used for research on multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, psoriasis, psoriatic arthritis, Crohn's disease, Sjögren's syndrome, and scleroderma.
JAK   Interleukin Related  
Digestive System Disease   Digestive System Inflammation   Systemic Lupus Erythematosus   Multiple Sclerosis   Crohn's Disease   Psoriasis   Rheumatoid Arthritis  
/
HY-P9943 Igovomab
Igovomab is a monoclonal antibody for imaging. Igovomab can be used for ovarian cancer research.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-B1139S Tolperisone-d10 hydrochloride
Tolperisone-d10 (hydrochloride) is the deuterium labeled Tolperisone hydrochloride. Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-NP071 Lycopersicon esculentum (Tomato) Lectin
Lycopersicon esculentum (Tomato) Lectin (LEL) specifically recognizes and binds to sugar structures, that combines with fluorescein for fluorescent labeling and imaging of cells and tissues. Lycopersicon esculentum (Tomato) Lectin is used to visualizes the vasculature within transplanted tissues by labeling with fluorescein.
Biochemical Assay Reagents  
/
HY-P991351 RTX-002
RTX-002 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. RTX-002 can be used to study autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.

Species: Human

PD-1/PD-L1  
Inflammation or Immune System Disease  
/
HY-N3482 Isogarciniaxanthone E
Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth.
Others  
Neurological, Eye or Ear Disease  
/
HY-D1317A Cyanine7.5 carboxylic
Cyanine7.5 carboxylic is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid functional groups. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Cyanine7.5 carboxylic can be covalently bound to some biological molecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-N21616 Demethyltorosaflavone C
Demethyltorosaflavone C is a Free Radical Scavenger, with DPPH• scavenging IC50 values of 47.7 μM and 1.36 mM in different experimental systems. The catechol group on the B ring of Demethyltorosaflavone C promotes hydrogen donation and resonance stabilization of the phenoxyl radical, thereby exerting its free radical scavenging effect. Demethyltorosaflavone C can be used in studies on oxidative stress and natural product flavonoids.
Free Radical Scavengers  
Oxidative Stress and Inflammation  
/
HY-P1567 β-Amyloid (10-35), amide
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-W012634R Benzothiazole (Standard)
Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent.
Reference Standards   Bacterial  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P1052 Myelin Basic Protein(87-99)
Myelin Basic Protein(87-99) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS).
Others  
Inflammation or Immune System Disease  
/
HY-34465R 5-Methyl-2-thiophenecarboxaldehyde (Standard)
5-Methyl-2-thiophenecarboxaldehyde (Standard) is the analytical standard of 5-Methyl-2-thiophenecarboxaldehyde. This product is intended for research and analytical applications. 5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material[1].
Biochemical Assay Reagents   Reference Standards  
/
HY-P991866 BI 1034020
BI 1034020 is a humanized nanobody, targeting two different epitopes of Aβ ( Aβ40 and Aβ42) with high affinity. BI 1034020 reduces the level of free Ab peptide in plasma and thus prevent the formation of new Aβ plaques and clear existing plaques. BI 1034020 can be used for Alzheimer’s disease research.

Species: Human

Amyloid-β  
Alzheimer's Disease  
/
HY-N10273 Deoxyfusapyrone
Deoxyfusapyrone is an antifungal alpha-pyrone from Fusarium semitectum. Deoxyfusapyrone shows a strong antibiotic activity towards Geotrichum candidum in disk diffusion assays, but is not toxic to Artemia salina larvae.

Source: Fusarium semitectum Berk. & Rav.

Fungal  
Infection  
/
HY-B1804S1 Tricaprilin-d50
Tricaprilin-d50 (Trioctanoin-d50) is the deuterium labeled Tricaprilin (HY-B1804). Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT).
Isotope-Labeled Compounds   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-13599S4 Cladribine-13C,15N2
Cladribine-13C,15N2 (2-Chloro-2′-deoxyadenosine-13C,15N2) is the 13C- and 15N-labeled Cladribine (HY-13599). Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active?adenosine deaminase?inhibitor. Cladribine functions as an inhibitor of?DNA synthesis?to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds   Adenosine Deaminase   Apoptosis  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-113410S 3-Methylglutaric acid-d4
3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid (HY-113410). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
Isotope-Labeled Compounds   Na+/K+ ATPase   Mitochondrial Metabolism   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-122957 Huperzine C
Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC50 of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease.
Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-12355S Siponimod-d11
Siponimod-d11 (BAF-312-d11) is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.
Isotope-Labeled Compounds   Potassium Channel   LPL Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P11850 PTP peptide
PTP peptide is a specific Plectin-1 binder. PTP peptide can serve as a component of imaging agents; when conjugated with magnetofluorescent nanoparticles, it enables the detection of small pancreatic ductal adenocarcinomas and precancerous lesions via in vivo confocal microscopy and MRI. When conjugated with imaging agents, PTP peptide specifically targets pancreatic ductal adenocarcinoma cells, and can be used for tumor visualization and compound delivery. PTP peptide is applicable to research related to pancreatic ductal adenocarcinoma.
Radionuclide-Drug Conjugates (RDCs)  
Pancreatic Ductal Adenocarcinoma  
/
HY-W284558S Sodium hexadecyl sulfate-d33
Sodium hexadecyl sulfate-d33 is the deuterium labeled Sodium hexadecyl sulfate. Sodium hexadecyl sulfate is a long-chain anionic surfactant. Sodium hexadecyl sulfate can act as an interface-regulating substance to form a soft layer on the surface of carbon nanotubes, guide proteins to adsorb in the correct orientation with active sites facing outward through electrostatic interactions, and significantly enhance the activity of immobilized enzymes. Sodium hexadecyl sulfate can replace or supplement SDS (HY-Y0316) in capillary gel electrophoresis (CGE).
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-178395S Tricosanoic acid-d45
Tricosanoic acid-d45 is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline.
Isotope-Labeled Compounds   Free Fatty Acid Receptor  
/
HY-W009310R 9-cis-Retinal (Standard)
Mebrofenin (Standard) is the analytical standard of Mebrofenin. This product is intended for research and analytical applications. Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function.
Reference Standards   Endogenous Metabolite   Organoid  
/
HY-D3000 NIR-RED ROS-H2O2 Probe
NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).
Fluorescent Dye  
Liver Injury  
/
HY-159526 Adarulatide tetraxetan
Copper adarulatidum tetraxetanum (Copper adarulatide tetraxetan) is a diagnostic imaging agent.
Biochemical Assay Reagents  
/
HY-P991536 KHK6640
KHK6640 is a humanized anti-amyloid beta oligomer-specific antibody. KHK6640 demonstrates high potency and efficacy for cognitive improvement in several rodent Alzheimer’s models. KHK6640 can be studied in research for neurological diseases such as Alzheimer’s disease.

Species: Human

Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-P2562 β-Amyloid (1-38), mouse, rat
β-Amyloid (1-38), mouse, rat is composed of 38 aa (1-38 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-P11867 UM206_L
UM206_L is a linear Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces.
Wnt   β-catenin  
/
HY-P10590 Talogreptide mesaroxetan
Talogreptide mesaroxetan is a diagnostic imaging agent, with antineoplastic effect.
Fluorescent Dye  
Cancer  
/
HY-W746542 Tricosanoic acid-d3
Tricosanoic acid-d3 is the deuterium labeled Tricosanoic acid (HY-W009081). Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline.
Isotope-Labeled Compounds   Free Fatty Acid Receptor  
/
HY-P3541 Dirucotide
Dirucotide (MBP8298) is a synthetic peptide that consists of 17 amino acids linked in a sequence identical to that of a portion of human myelin basic protein. Dirucotide can be used for the research in autoimmune disorder of the central nervous system, such as Multiple sclerosis (MS).
Others  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-W134328B Blue dextran (MW 10000)
Blue dextran (Dextran blue) (MW 10000) is a 10 kDa osmotic dextran. Blue dextran (MW 10000) penetrates all sublayers of the pre-epithelial mucus gel layer in the rat distal colon and is taken up by the nuclei of surface cells in the rat distal colonic mucosa. Blue dextran (MW 10000) is not blocked by the pre-epithelial mucus gel layer of the rat distal colon, which acts as a diffusion barrier.
Biochemical Assay Reagents  
/
HY-D2378 Abenacianine
Abenacianine is a diagnostic imaging agent.
Biochemical Assay Reagents  
Cancer  
/
HY-W585827S1 2-Chloro-1,3-propanediol-d5 (major)
2-Chloro-1,3-propanediol-d5 (major) (2-MCPD-d5 (major)) is the deuterated-labeled 2-Chloro-1,3-propanediol (HY-W585827). 2-Chloro-1,3-propanediol (2-MCPD) is a pharmaceutical intermediate. 2-Chloro-1,3-propanediol is a common glycerol-derived chemical intermediate and also a food processing contaminant. 2-Chloro-1,3-propanediol can cross the intestinal barrier model via paracellular diffusion. 2-Chloro-1,3-propanediol induces renal and testicular toxicity in animal models. 2-Chloro-1,3-propanediol can be used in research related to organic synthesis.
Isotope-Labeled Compounds   Drug Derivative  
/
HY-P991725 Velvakiment
Velvakiment is a humanized VHH nanobody that targets IL-17A. Velvakiment can be used for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis research.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P10157 ARF(1-22)
ARF(1-22) is potentially capable of intracellular penetration to deliver small molecules, proteins, imaging agents, and pharmaceutical nanocarriers.
Biochemical Assay Reagents  
/
HY-P11739 ZD2 peptide
ZD2 peptide is an EDB-FN-binding peptide with a Kd value of 11 μM. ZD2 peptide binds specifically to the EDB protein fragment of extradomain B fibronectin, a tumor microenvironment biomarker. ZD2 peptide can be conjugated to imaging agents. ZD2 peptide can be used for the research of cancer.
Biochemical Assay Reagents  
Cancer  
/
HY-P991596 ANB004
ANB004 is a humanized monoclonal antibody inhibitor, targeting IL-17. ANB004 can be used for autoimmune and inflammatory diseases like multiple sclerosis and rheumatoid arthritis (RA) research.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P2493 (Cys47)-HIV-1 tat Protein (47-57)
(Cys47)-HIV-1 tat Protein (47-57) has membrane translocation function and can be used to derivatize the surface of magnetic pharmaceuticals and substantially facilitated their uptake into target cells.
HIV  
/
HY-180346 Hepta-histidine
Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease.
Huntingtin  
Huntington's Disease  
/
HY-P10522 MBP Ac1-9
MBP Ac1-9 refers to a peptide fragment of myelin basic protein (MBP). MBP Ac1-9 is an immunodominant epitope in the experimental autoimmune encephalomyelitis (EAE) model, which can induce T cell immune response and lead to pathological changes similar to multiple sclerosis. MBP Ac1-9 can be used to study T cell activation and autoimmune response.
Others  
/
HY-N18411 Tanacetin
Tanacetin is a sesquiterpenoid compound discovered in the whole herb of Crossostephium chinense (L.) Makino. Sesquiterpene lactones, the class to which Tanacetin belongs (e.g., constituents of plants in the Tanacetum genus), inhibit the inflammatory mediators prostaglandins and leukotrienes. Tanacetin crosses intestinal cell monolayers primarily via transcellular passive diffusion, and no significant first-pass metabolism occurs during its intestinal absorption. Tanacetin is used in research related to diabetes, migraine, and rheumatoid arthritis.
Biochemical Assay Reagents  
Migraine   Type 1 Diabetes   Rheumatoid Arthritis  
/
HY-N10325 Sarbronine M
Scabronine M is a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells.

Source: fungus Sarcodon scabrosus

Others  
/
HY-165424 NIR-BG2
NIR-BG2 is a fluorescent indicator targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 contains a hemicyanine fluorophore caged by SA-β-Gal; cleavage of its β-galactosyl group by SA-β-Gal generates an electrophilic quinone methide, which can form covalent bonds with adjacent proteins to achieve long-term signal retention. NIR-BG2 activates a near-infrared fluorescent signal upon recognition of SA-β-Gal. NIR-BG2 can be used for non-invasive in vivo imaging of cellular senescence in mouse xenograft models. The excitation/emission wavelengths are 675/708 nm.
Fluorescent Dye   Glycosidase  
/
HY-W777002 Famotidine-13C3
Famotidine-13C3 (MK-208-13C3) is the 13C3-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-P11046 IIIM1
IIIM1 is an orally active anti-inflammatory peptide. IIIM1 ameliorates the symptoms of experimental autoimmune encephalomyelitis (EAE) by stimulating the proliferation of regulatory T cells and inducing them to produce RA1, and regulating the cytokine balance. IIIM1 can be used in the research of multiple sclerosis (MS).
Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P1060 LPYFD-NH2
LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease.
Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-N16296 Cyanine 7.5 NHS chloride
Cy7.5 NHS ester chloride is a fluorescent dye. Cy7.5 NHS ester chloride can be conjugated to mPEG-b-PDPA to form a mPEG-b-PDPA-Cy7.5 fluorescent copolymer. Cy7.5 NHS ester chloride can be used for fluorescent imaging study (Ex/Em = 780/820 nm).
Fluorescent Dye  
/
HY-P3724 MBP (146-170)
MBP (146-170) is a myelin basic protein (MBP). MBP (146-170) can be used for the research of multiple sclerosis (MS).
Others  
Inflammation or Immune System Disease  
/
HY-W707517 Famotidine-d4
Famotidine-d4 (MK-208-d4) is the deuterated-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-D1615 BODIPY 530/550 NHS ester
BODIPY 530/550 NHS ester can be used for the stain of protein. BODIPY 530/550 NHS ester can be used for fluorescence OIM (oblique illumination microscopic) image.
Fluorescent Dye  
/
HY-141637S 2-Deoxy-2-fluoro-D-glucose-13C
2-Deoxy-2-fluoro-D-glucose-13C is the 13C labeled 2-Deoxy-2-fluoro-D-glucose (HY-141637). 2-Deoxy-2-fluoro-D-glucose (2-Fluoro-2-deoxy-D-glucose) is a glucose analog that can be absorbed by cells. 2-Deoxy-2-fluoro-D-glucose is capable of being labelled with 18F for positron emission tomography (PET) imaging. 18F-2-Deoxy-2-fluoro-D-glucose can be used to detect breast cancer and gastric cancer.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-D1864 Sulfo-Cy7.5 dicarboxylic acid
Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-D1866 Sulfo-Cy7.5 carboxylic acid
Sulfo-Cy7.5 carboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate ion (sulfonate) functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 carboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-Y0850U8 PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization)
PVA (Polyvinyl alcohol; Poly(Ethenol)) (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) is a semicrystalline synthetic polymer with excellent biocompatibility and biodegradability, which is non-toxic and non-mutagenic upon oral administration in the human body. PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) can serve as an excipient, inhibitor or coating agent to prepare solid dispersions by absorbing water and inhibiting drug crystal nucleation and growth, and can encapsulate insulin-like growth factor-1. PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) can form physically crosslinked cryogels and degradable films, and is widely used in the construction of vascular grafts, the synthesis of articular cartilage, and studies on dry or minimally invasive ex vivo wounds. PVA (Mw 47000, 98-99% hydrolyzed, ~1000 polymerization) also promotes hydrogen peroxide generation and enhances the redox cycle of iron species, thus acting as a sacrificial agent to effectively degrade pollutants.
Biochemical Assay Reagents  
/
HY-P1996 Tiplimotide
Tiplimotide (NBI-5788) is an altered peptide ligand (APL) designed from an immunodominant region (83-99) of the neuroantigen myelin basic protein (MBP). Tiplimotide can selectively reduce the production of inflammatory cytokines by pathogenic T-cells. Tiplimotide can be used for the research of multiple sclerosis (MS).
Others  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P11263 AVLX-144
AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95). AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease.
iGluR  
Parkinson's Disease  
/
HY-P5229 IHRIC
IHRIC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Others  
/
HY-D3485 Dexamethasone fluorescein
Dexamethasone fluorescein is a fluorescently labeled steroid conjugate that binds to glucocorticoid receptors. Dexamethasone fluorescein binds to glucocorticoid receptors. Dexamethasone fluorescein serves as a marker for evaluating the delivery of drugs via subconjunctival injection and intratympanic administration. Sustained transscleral diffusion is achieved when Dexamethasone fluorescein is delivered via fibrin sealant. Dexamethasone fluorescein can be used to investigate the binding and localization of glucocorticoid receptors.
Fluorescent Dye   Glucocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-P992459 SGM-101 Antibody
SGM-101 Antibody is a chimeric monoclonal antibody targeting carcinoembryonic antigen (CEA). SGM-101 Antibody can serve as a tumor-specific fluorescent imaging probe after being covalently conjugated with the near-infrared fluorescent dye BM104. SGM-101 Antibody accumulates in CEA-positive tumor tissues via antigen-antibody specific binding, and emits near-infrared fluorescence to enable imaging of tumor lesions. SGM-101 Antibody can be used in research related to gastric cancer, colorectal cancer, pancreatic cancer, non-small cell lung cancer, breast cancer, peritoneal carcinomatosis, and liver metastases.

Species: Human

ADC Antibodies   Transmembrane Glycoprotein  
Cancer  
/
HY-P10878 UK140
UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with Ki of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research.
PAI-1  
Cancer  
/
HY-W324458 MCA succinimidyl ester
MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer.
Fluorescent Dye  
/
HY-P5984A Thioether-cyclized helix B peptide, CHBP TFA
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.
mTOR  
/
HY-D2962 CAQ
CAQ is a near-infrared fluorescent probe based on a curcumin scaffold (Ex/Em = 565/635). CAQ exhibits high affinity for Aβ1-42 aggregates (Kd = 78.89 nM) and excellent selectivity toward common biomolecules. CAQ’s emission wavelength shows significant solvent dependence. CAQ, by incorporating intramolecular rotation donors and quinoline functional groups, can be used for the specific detection and imaging of Aβ aggregates in Alzheimer's disease.
Fluorescent Dye  
Alzheimer's Disease  
/
HY-N4236 Angelol A
Angelol A is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model.
Others  
/
HY-106428 Icrocaptide
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca2+-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders.
P-selectin  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P1389S Neuropeptide S (human)-13C2,15N
Neuropeptide S (human)-13C2,15N is the 13C- and 15N-labeled Neuropeptide S (human) (HY-P1389). Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.
Isotope-Labeled Compounds  
/
HY-N9085 Neuchromenin
Neuchromenin is a microbial melabolite that can be isolated from the culture broth of Eupenicillium javanicum var. meloforme PFll81. Neuchromenin induces neurite outgrowth of PC12 cells.

Source: n Penicillium glabrum (SF-7123)

Bacterial  
Neurological, Eye or Ear Disease  
/
HY-W585827S 2-Chloro-1,3-propanediol-d5
2-Chloro-1,3-propanediol-d5 (2-MCPD-d5) is the deuterated-labeled 2-Chloro-1,3-propanediol (HY-W585827). 2-Chloro-1,3-propanediol (2-MCPD) is a pharmaceutical intermediate. 2-Chloro-1,3-propanediol is a common glycerol-derived chemical intermediate and also a food processing contaminant. 2-Chloro-1,3-propanediol can cross the intestinal barrier model via paracellular diffusion. 2-Chloro-1,3-propanediol induces renal and testicular toxicity in animal models. 2-Chloro-1,3-propanediol can be used in research related to organic synthesis.
Isotope-Labeled Compounds   Drug Derivative  
/
HY-P10744 BQ7859
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT). BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
Radionuclide-Drug Conjugates (RDCs)   PSMA  
/
HY-13963S ZCL278-13C
ZCL278-13C is a 13C-labeled version of ZCL278 (HY-13963). ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 can disrupt the interaction between Cdc42 and ITSN, and also inhibit the binding of GTP and GDP. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used in the research of arsenic neurotoxicity and HER2-positive gastric cancer (GC).
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Infection  
/
HY-P11887 VHPKQHR
VHPKQHR is a peptide-based delivery enhancer that binds to VCAM-1. VHPKQHR enables intracellular internalization of relevant nanomaterials and facilitates the targeted delivery of miRNA inhibitors to inflamed endothelial cells and endothelial cells activated by disturbed flow. When conjugated with magnetic mesoporous silica nanoparticles, VHPKQHR achieves targeted accumulation at atherosclerotic plaque sites. When displayed on the surface of polyelectrolyte complex micelles, VHPKQHR enhances the relevant effects of anti-miR-92a in Apoe-/- mice. When conjugated with ultrasmall superparamagnetic iron oxide nanoparticles, VHPKQHR forms a contrast agent for T1-weighted magnetic resonance imaging. VHPKQHR can be used in research related to atherosclerosis, stenosis and rheumatoid arthritis.
Transmembrane Glycoprotein   Radionuclide-Drug Conjugates (RDCs)  
Atherosclerosis and Inflammation   Rheumatoid Arthritis  
/
HY-109523S Cerivastatin-d3 sodium
Cerivastatin-d3 sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
Ferroptosis   HMG-CoA Reductase (HMGCR)   Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-P5228 KSDSC
KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Biochemical Assay Reagents  
/
HY-175310S Voderdeucitinib
Voderdeucitinib (Compoudn I) is a TYK2 inhibitor with an anti-inflammatory activity. Voderdeucitinib can be used for inflammatory and autoimmune disease research, such as rheumatoid arthritis (RA), multiple sclerosis and intestinal bowel disease (IBD).
JAK  
Inflammation or Immune System Disease  
/
HY-D2260 hMSCs-Neu perchlorate
hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-D3196 AG2
AG2 is a glucose uptake tracer and two-photon fluorescent probe. AG2 is taken up by cells via glucose-specific transport systems, rather than passive diffusion; it preferentially accumulates in cancer cells and colon cancer tissues compared with normal cells and tissues; it mainly localizes to mitochondria, with a small amount also distributed in the cytoplasm and cell membrane. AG2 can be used for colon cancer research.
Fluorescent Dye  
Cancer  
/
HY-N4235 Angelol B
Angelol B is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model.
Others  
Inflammation or Immune System Disease  
/
HY-W035399S1 D-Lysine-d4 dihydrochloride
D-Lysine-d4 dihydrochloride is the d4-labeled D-Lysine (HY-Y1091). D-Lysine is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine can be used in research related to cancer and diabetes.
Isotope-Labeled Compounds   Drug Isomer  
Cancer   Glucose Metabolism  
/
HY-16900G Rolipram (GMP)
Rolipram GMP is Rolipram (HY-16900) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis.
Phosphodiesterase (PDE)   Epigenetic Reader Domain   Amyloid-β  
Depression   Glioblastoma Multiforme   Alzheimer's Disease   Multiple Sclerosis  
/
HY-P11414 Cys-flag peptide
Cys-flag peptide (CDYKDDDDK) is a FLAG tag peptide containing cysteine. Cys-flag peptide has a targeted interaction for protein purification and detection. Cys-flag peptide can be used for the research of neurological disease, such as Alzheimer’s disease.
Others  
/
HY-13212R (Z)-2-Decenoic acid (Standard)
(Z)-2-Decenoic acid (Standard) is the analytical standard of (Z)-2-Decenoic acid. This product is intended for research and analytical applications. (Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development[1].
Bacterial   Reference Standards  
Cancer  
/
HY-W749825 Pentetic acid-13C5
Pentetic acid-13C5 (Diethylenetriaminepentaacetic acid-13C5) is the 13C-labeled Pentetic acid (HY-B1335). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide.
Isotope-Labeled Compounds   Fluorescent Dye  
/
HY-P10911 IETP2
IETP2 targets low-density lipoprotein receptor-related protein 1 (LRP1) with a KD of 738 nM and can be used for drug- and imaging agents delivery across the blood-labyrinth barrier (BLB).
LDLR  
/
HY-P10344 MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescent substrate used for fluorescence resonance energy transfer (FRET) protease assays. This substrate is employed to measure the activity of SARS-CoV-2 3CLpro.
Fluorescent Dye  
/
HY-P991867 SHR-1707
SHR-1707 is a humanized anti-Aβ IgG1 monoclonal antibody. SHR-1707 binds Aβ fibrils and monomers, blocking plaque formation and promoting the microglial phagocytosis of Aβ. SHR-1707 reduces brain Aβ deposition in 5xFAD transgenic mice. SHR-1707 can be used for Alzheimer’s disease research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Amyloid-β  
Alzheimer's Disease  
/
HY-P991569 PF-04840082
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research.

Species: Human

Wnt  
Metabolic or Endocrine Disease  
/
HY-D3404 BODi-1
BODi-1 is a fluorescent modulator targeting dsDNA, which binds to dsDNA via a bis-intercalation mechanism (Ex=465 nm, Em=490 nm). BODi-1 exhibits a fluorescence enhancement effect upon binding to nucleic acids, but its fluorescence intensity, anisotropy and average lifetime decrease at higher dye/DNA ratios. When BODi-1 binds to DNA in liposome complexes, it also shows red-shifted emission spectra, along with reduced quantum yield and average lifetime. BODi-1 does not induce significant DNA conformational changes when the dye/DNA ratio is below 0.01. BODi-1 can be used as a fluorescent probe for the characterization of liposome complexes and FRET studies at this ratio.
DNA Stain  
/
HY-D0534 2-4-(2-Cyanoethyl)(2-phenylethyl)aminophenylazo-5-nitrobenzonitrile
2-4-(2-Cyanoethyl)(2-phenylethyl)aminophenylazo-5-nitrobenzonitrile is a storage-stable, fluid, nonagglomerating dispersions of azo dye.
Fluorescent Dye  
/
HY-107116S MAP4343-d4
MAP4343-d4 is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.
Isotope-Labeled Compounds   Microtubule/Tubulin  
Neurological, Eye or Ear Disease  
/
HY-P10039 β Amyloid (1-16) rat
β-Amyloid (1-16) rat is a β-amyloid peptide (Abeta), a metal-binding domain fragment of amyloid. Three amino acid substitutions in β-Amyloid (1-16) rat that differ from humans render rats and mice less susceptible to AD-like neurodegeneration.
Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-P992097 Fanolesomab
Fanolesomab is an anti-human CD15-targeting monoclonal antibody. Fanolesomab binds to the CD15 epitope on white blood cells to enable imaging of white blood cell distribution, migration, and infection sites. Fanolesomab can be used for the research of infection.

Species: Human

Transmembrane Glycoprotein  
Infection  
/
HY-P11236 Cronexitide lanocianine
Cronexitide lanocianine is a diagnostic imaging agent.
Biochemical Assay Reagents  
/
HY-168947A Green Fluorescent PLGA nanoparticles, 200nm
Green Fluorescent PLGA nanoparticles, 200nm is a PLGA nanoparticle labeled with a green fluorescent dye and is commonly used in imaging and diagnostic applications.
Fluorescent Dye  
/
HY-168947B Green Fluorescent PLGA nanoparticles, 500nm
Green Fluorescent PLGA nanoparticles, 500nm is a PLGA nanoparticle labeled with a green fluorescent dye and is commonly used in imaging and diagnostic applications.
Fluorescent Dye  
/
HY-D2343 PB0822
PB0822 can be used for in vivo PET imaging when labeled with [18F]fluoride. [18F]PB0822 is a PET radioligand. [18F]PB0822 has a cLogP value of 1.54, which is a good predictive index for BBB penetration. [18F]PB0822 can be used for Alzheimer’s Disease research.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-P5984 Thioether-cyclized helix B peptide, CHBP
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.
mTOR  
/
HY-112798S PH-002-d8
PH-002-d8 is the deuterium labeled PH-002 (HY-112798). PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
Isotope-Labeled Compounds   Apolipoprotein  
Neurological, Eye or Ear Disease  
/
HY-P99648A Gosuranemab (powder)
Gosuranemab (BMS-986168; IPN007; BIIB092) (powder) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab (powder) neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab (powder) can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease.
Tau Protein  
Alzheimer's Disease  
/
HY-B0531S Triflusal-d3
Triflusal-d3 is deuterium labeled Triflusal (HY-B0531). Triflusal is an orally bioavailable, blood-brain barrier-permeable dual Cyclooxygenase-1 (COX-1)/cAMP phosphodiesterase inhibitor. Triflusal inhibits platelet aggregation, NF-κB activation, iNOS activity, and prostaglandin synthesis in ischaemic tissue. Triflusal stimulates neutrophil nitric oxide production, eNOS protein expression, and cNOS activity. Triflusal alleviates cerebral ischemic injury in rats and ameliorates pathological lesions and related gene expression in transgenic Alzheimer’s disease models. Triflusal can be used for the research of thromboembolic/ischemic cardiovascular and cerebrovascular diseases, and Alzheimer’s disease.
Isotope-Labeled Compounds   COX   NF-κB   Phosphodiesterase (PDE)   NO Synthase   Prostaglandin Receptor  
Colorectal Cancer   Prostate Cancer   Pancreatic Cancer   Depression   SARS-CoV-2 Infection   Rheumatoid Arthritis  
/
HY-114133 Depreotide
Depreotide is a nove tumor tarcer, can be complexed with technetium-99m (99mTc-depreotide) for optimal imaging properties. 99mTc-depreotide somatostain receptor imaging has been playing an important role in medical diagnosis research. Depreotide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
Radionuclide-Drug Conjugates (RDCs)   Somatostatin Receptor  
/
HY-P10297 PLP (190-209)
PLP (190-209) is a myelin proteolipid protein (PLP) fragment. PLP (190-209) is used to induce experimental autoimmune encephalomyelitis (EAE) animal models for multiple sclerosis research.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-P991650 MDX1201
MDX1201 is a humanized monoclonal antibody targeting PSMA1/7. MDX1201 conjugated with a fluorescent dye AlexaTM488 can be used as a probe for near-infrared fluorescence imaging (NIRF) imaging of prostate cancer.

Species: Human

PSMA  
Cancer  
/
HY-17387S1 (-)-Huperzine A-d4 hydrochloride
(-)-Huperzine A-d4 hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
iGluR   Apoptosis   Cholinesterase (ChE)   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-N15649 Ostruthol
Ostruthol is a coumarin and a potent inhibitor of AChE. Ostruthol can be studied in research on Alzheimer’s disease.
Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-P10680 TFE-IDAtp1-LinA
TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA, formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED50 of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP).
Liposome  
/
HY-168947 Green Fluorescent PLGA nanoparticles, 100nm
Green Fluorescent PLGA nanoparticles, 100nm is a PLGA nanoparticle labeled with a green fluorescent dye and is commonly used in imaging and diagnostic applications.
Fluorescent Dye  
/
HY-W009300S1 4-Hydroxyestrone-13C6
4-Hydroxyestrone (4-OHE1)-13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
Isotope-Labeled Compounds   Endogenous Metabolite   Estrogen Receptor/ERR   Sirtuin   MDM-2/p53   PDI   Ferroptosis   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B0377S Famotidine-13C,d3
Famotidine-13C,d3 (MK-208-13C,d3) is the deuterated, 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-B0926S Diatrizoic acid-d6
Diatrizoic acid-d6 (Diatrizoate-d6; Amidotrizoic acid-d6) is the deuterium labeled Diatrizoic acid (HY-B0926). Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium.
Isotope-Labeled Compounds   Apoptosis  
Inflammation or Immune System Disease  
/
HY-P11867A UM206_C
UM206_C is a circular Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces.
Wnt   β-catenin  
/
HY-P991654 SAR228810
SAR228810 is a humanized IgG4 monoclonal antibody inhibitor targeting amyloid β (Aβ) with a KD? of ?0.43 ?nM for protofibrillar Aβ over monomeric Aβ. SAR228810 significantly inhibits the brain amyloid plaque formation and oligomer-induced synaptic dysfunction and neurite loss. SAR228810 has significant protection against Aβ-mediated neuritotoxicity. MINT1526A can be used for Alzheimer’s disease imaging and immunotherapy research.

Species: Human

Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-A0168S Regadenoson-d3
Regadenoson-d3 is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents.
Isotope-Labeled Compounds   Adenosine Receptor  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-P1385 TCS 183
TCS 183, a peptide, is a GSK-3β inhibitor. TCS 183 blocks GSK-3β autoinhibition and decreases the level of AMPK phosphorylation. TCS 183 can be used for neuropathological diseases, particularly Alzheimer’s disease, research.
GSK-3   p38 MAPK  
Neurological, Eye or Ear Disease  
/
HY-184832 P021
P021 (Peptide 021) is an orally active, blood-brain barrier penetrant neurotrophic/neurogenic pentapeptide derived from the most active region of ciliary neurotrophic factor (CNTF). P021 competitively inhibits leukemia inhibitory factor (LIF) and promotes BDNF transcription. P021 targets neurogenesis and synaptic plasticity. P021 prevents neurodegeneration, Amyloid-β pathology, tau protein pathology and cognitive deficits, rescues episodic memory impairment and reduces mortality in 3xTg-AD mice. P021 is applicable to the research of Alzheimer's disease.
Amyloid-β   Tau Protein  
Alzheimer's Disease  
/
HY-P10936 AQP4 (201-220)
AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica.
Aquaporin  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-D3240 Photoactive NTR probe
Photoactive NTR probe (Compound 1) is a covalent crosslinker and Fluorescent indicator targeting Nitroreductase. The Photoactive NTR probe undergoes a sequential activation process: it is first activated via nitroreductase-mediated nitro-to-amino conversion, and then forms a fluorescent product upon photoactivation. The Photoactive NTR probe can form covalent adducts with the side chains of cysteine, tyrosine, lysine and histidine in adjacent proteins to reduce fluorophore diffusion. The Photoactive NTR probe enables super-resolution (STORM) imaging of active mitochondrial nitroreductase microdomains in living cells.
Fluorescent Dye  
/
HY-D1991 ATTO 647
ATTO 647 is a carborhodamine fluorophore and imaging tracer with photostable properties. ATTO 647 serves as a fluorescent probe to investigate cell membrane structure and diffusion characteristics. When conjugated with wheat germ agglutinin, ATTO 647 specifically binds to N-acetyl-β-D-glucosamine and sialic acid residues on membrane glycoproteins, enabling single-molecule tracing of glycoprotein diffusion. ATTO 647 exhibits highly stable fluorescence properties with significantly reduced blinking in mounting media such as ROXS (AA/MV) and ROXS (TX/TQ), whereas its brightness properties vary in Ibidi-MM and Vectashield. ATTO 647 can also be used to label histone H2B-GFP in fixed cells for confocal microscopy photobleaching experiments.
Fluorescent Dye  
/
HY-P4948 Coumarin-Phalloidin
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton.
Biochemical Assay Reagents  
/
HY-W752886 Estradiol 3-d3 (β-D-Glucuronide) sodium
Estradiol 3-d3 (β-D-Glucuronide) sodium is the deuterium labeled Estradiol 3-(β-D-Glucuronide) sodium (HY-N7755). Estradiol 3-(β-D-Glucuronide) sodium is the glucuronic acid derivative of estradiol (HY-B0141). Estradiol 3-(β-D-Glucuronide) sodium is radiolabeled for use in tumor imaging and biodistribution studies.
Isotope-Labeled Compounds   Estrogen Receptor/ERR  
/
HY-P1389A Neuropeptide S (human) TFA
Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research.
Neuropeptide S Receptor  
Neurological, Eye or Ear Disease  
/
HY-141637S1 2-Deoxy-2-fluoro-D-glucose-13C6,d7
2-Deoxy-2-fluoro-D-glucose-13C6,d7 is the 13C-labeled and deuterium labeled 2-Deoxy-2-fluoro-D-glucose (HY-141637). 2-Deoxy-2-fluoro-D-glucose (2-Fluoro-2-deoxy-D-glucose) is a glucose analog that can be absorbed by cells. 2-Deoxy-2-fluoro-D-glucose is capable of being labelled with 18F for positron emission tomography (PET) imaging. 18F-2-Deoxy-2-fluoro-D-glucose can be used to detect breast cancer and gastric cancer.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
Cancer  
/
HY-D2642 Cy5 HA (MW 10000)
Cy5 HA (MW 10000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-D0356 Eriochrome Black A
Eriochrome Black A is an azo dye that can be removed from water by an adsorbent made of magnetic NiFe2O4 nanoparticles.
Fluorescent Dye  
/
HY-117259S Valiltramiprosate-d6
Valiltramiprosate-d6 (ALZ-801-d6) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.
Isotope-Labeled Compounds   Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-D2621 Cy3 HA (MW 5000)
Cy3 HA (MW 5000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 5000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-D2624 Cy3 HA (MW 10000)
Cy3 HA (MW 10000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-W066890R 4-Nitrocatechol (Standard)
4-Nitrocatechol (Standard) is the analytical standard of 4-Nitrocatechol (HY-W066890). This product is intended for research and analytical applications. 4-Nitrocatechol is a Lipoxygenase inhibitor. 4-Nitrocatechol can serve as a ligand to stabilize the formation of metal complexes. As a (+) MALDI matrix, 4-Nitrocatechol significantly enhances the MALDI-MS detection and imaging of low-molecular-weight compounds in animal and plant tissue sections.
Reference Standards   Lipoxygenase   Biochemical Assay Reagents  
/
HY-106594BR Prussian blue soluble (Standard)
Prussian blue soluble (Standard) is the analytical standard of Prussian blue soluble (HY-106594B). This product is intended for research and analytical applications. Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI).
Reference Standards   Bacterial  
/
HY-N12919 (E)-3-Dodecenol
(E)-3-Dodecenol is a termite trail pheromone that can be isolated from the whole body and thymus extracts of termite workers. (E)-3-Dodecenol induces orientational and recruitment behavior effects, but its induction effect is weaker than (Z)-Dodecenol or natural thymus extracts.

Source: Macrotermes annandalei

Sex Pheromone  
Metabolic or Endocrine Disease  
/
HY-N14424 Indocarbazostatin B
Indocarbazostatin B against Neurite outgrowth induced by NGF is 24 nM in rat pheochromocytoma PC12 cells.

Source: Streptomyces sp

Others  
Neurological, Eye or Ear Disease  
/
HY-122381R Kyotorphin (Standard)
Kyotorphin (Standard) is the analytical standard of Kyotorphin. This product is intended for research and analytical applications. Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients.
Bacterial   Endogenous Metabolite   Reference Standards  
Neurological, Eye or Ear Disease  
/
HY-N5077R Sinapine (Standard)
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
Reference Standards   Cholinesterase (ChE)   P-glycoprotein  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-B0377S1 Famotidine-13C
Famotidine-13C (MK-208-13C) is the 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.
Isotope-Labeled Compounds   Histamine Receptor   MMP   Toll-like Receptor (TLR)   ERK  
Coronavirus Infection   Pneumonia   Gastric Ulcer   Liver Injury  
/
HY-13599S2 Cladribine-15N
Cladribine-15N (2-Chloro-2′-deoxyadenosine-15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds   Adenosine Deaminase   Apoptosis  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-D2622 Cy3 HA (MW 3000)
Cy3 HA (MW 3000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 3000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-132485S N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers)
N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers).
Isotope-Labeled Compounds  
/
HY-128417AR alpha-D-glucose hydrate (Standard)
alpha-D-glucose (hydrate) (Standard) is the analytical standard of alpha-D-glucose (hydrate). This product is intended for research and analytical applications. alpha-D-glucose hydrate is a monosaccharide and the most common form of glucose. It is a monosaccharide, which means it cannot be broken down into simpler sugars. alpha-D-glucose plays a vital role in energy metabolism and is the primary source of energy for many cells in the body. It is also a building block of larger carbohydrates such as starch and glycogen. The "α" prefix refers to the orientation of the hydroxyl group attached to the first carbon atom. Alpha-D-glucose exists in solution as a hydrate, which means it is bound to water molecules.
Biochemical Assay Reagents   Reference Standards  
/
HY-N10782 Balanophonin
Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis.
Apoptosis   COX   TNF Receptor   p38 MAPK  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-13599S Cladribine-d4
Cladribine-d4 (2-Chloro-2′-deoxyadenosine-d4) is deuterium labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-N0406R 2"-O-beta-L-galactopyranosylorientin (Standard)
2"-O-beta-L-galactopyranosylorientin (Standard) is the analytical standard of 2"-O-beta-L-galactopyranosylorientin. This product is intended for research and analytical applications. 2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect.
Reference Standards   Others  
Inflammation or Immune System Disease  
/
HY-D2623 Cy3 HA (MW 7000)
Cy3 HA (MW 7000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 7000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-D2443 AF594 DBCO
AF594 DBCO is an AlexaFluor 594-conjugated DBCO click chemistry probe for fluorescent labeling of azido-modified cholesterol probes. DBCO is a commonly used chemical biomarker group. AF594 DBCO (Excitation wavelength about 590 nm, emission wavelength about 617 nm) can be used to label proteins, cells and other biomolecules for fluorescence imaging and flow cytometry detection.
Fluorescent Dye  
Cancer  
/
HY-13599S1 Cladribine-13C5,15N2
Cladribine-13C5,15N2 (2-Chloro-2′-deoxyadenosine-13C5,15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-D2625 Cy3 HA (MW 50000)
Cy3 HA (MW 50000) is a hyaluronic acid labeled with CY3 (HY-D0822). Cy3 HA (MW 50000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 550/570 nm).
Fluorescent Dye  
/
HY-N14417 Indocarbazostatin
Indocarbazostatin against Neurite outgrowth induced by NGF is 6 nM in rat pheochromocytoma PC12 cells.

Source: Streptomyces sp

Others  
Neurological, Eye or Ear Disease  
/
HY-W674037 cis-Verbenol
cis-Verbenol is a sex pheromone capable of inhibiting aggregation and inducing dispersion of mountain pine beetles (Dendroctonus ponderosae Hopkins) and can be isolated from pine engravers.

Source: Dendroctonus ponderosae Hopkins

Sex Pheromone  
Metabolic or Endocrine Disease  
/
HY-101183R THK5351 (Standard)
THK5351 (Standard) is the analytical standard of THK5351 (HY-101183). This product is intended for research and analytical applications. THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
Tau Protein   Reference Standards  
/
HY-D2638 Cy5 HA (MW 3000)
Cy5 HA (MW 3000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 3000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-W674037R cis-Verbenol (Standard)
cis-Verbenol (Standard) is the analytical standard of cis-Verbenol (HY-W674037). This product is intended for research and analytical applications. cis-Verbenol is a sex pheromone capable of inhibiting aggregation and inducing dispersion of mountain pine beetles (Dendroctonus ponderosae Hopkins) and can be isolated from pine engravers.
Sex Pheromone   Reference Standards  
/
HY-122607S DPA-714-d10
DPA-714-d10 is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
Isotope-Labeled Compounds   TSPO   Mitochondrial Metabolism  
Cancer   Inflammation or Immune System Disease  
/
HY-10163AS Dabigatran-d4 hydrochloride
Dabigatran-d4 (hydrochloride) is deuterium labeled Dabigatran, which is a reversible and selective, direct thrombin inhibitor (DTI) with a Ki value of 4.5 nM.
Thrombin  
Blood or Cardio-cerebrovascular Disease  
/
HY-W041171S 3-Chloro-L-tyrosine-13C6
3-Chloro-L-tyrosine-13C6 is the 13C labeled 3-Chloro-L-tyrosine. 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
Endogenous Metabolite  
/
HY-P9937 Arcitumomab
Arcitumomab is a murine anti-carcinoembryonic antigen (CEA) monoclonal antibody Fab’ fragment. Arcitumomab can be labeled with technetium-99m and can be used for single-photon emission computed tomography (SPECT) imaging.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-N12581 Kuwanon U
Kuwanon U is a potent cholinesterase inhibitor with IC50s of 19.69, 10.11 µM and Kis of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD).
Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-P10877 Bicyclic UK18
Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a Ki of 53 nM.
PAI-1  
Cancer  
/
HY-B1018AS Phenelzine-d5 sulfate
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer.
Isotope-Labeled Compounds   Monoamine Oxidase   GABA Receptor   Histone Demethylase  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P11742 WALP23
WALP23 is a synthetic model peptide. WALP23 induces heterogeneity in lipid bilayers, forming stripe-like microdomains in DPPC bilayers. WALP23 can be used to study protein-membrane interactions. WALP23 is also used as a model peptide to determine helical orientation during the association process.
Biochemical Assay Reagents  
/
HY-P5229A IHRIC TFA
IHRIC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Others  
/
HY-W042284 Tetradecyl acetate
Tetradecyl (Myristyl) acetate is a native sex pheromone component of Yponomeuta rorellus. Tetradecyl acetate elicits orientation behaviour, upwind flight, and landing at the odour source in male Yponomeuta rorellus. Tetradecyl acetate can be used in research on insecticides.

Source: Ctenopseustis obliquana

Sex Pheromone   Insecticide  
/
HY-W674241A 4-Ethylphenyl sulfate sodium
4-Ethylphenyl sulfate sodium is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate sodium downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate sodium induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate sodium impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate sodium alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice.

Source: goat urine

Endogenous Metabolite   Apoptosis   Bcl-2 Family   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P5228A KSDSC TFA
KSDSC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi).
Biochemical Assay Reagents  
/
HY-P4704 α-Synuclein (61-95) (human)
α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-B1028S Pantethine-15N2
Pantethine-15N2 is the 15N2 labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration.
Isotope-Labeled Compounds  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-34465 5-Methyl-2-thiophenecarboxaldehyde
5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material.
/
HY-N11001 Erinacine U
Erinacine U is a cyanogen diterpene isolated from Hericium erinaceus, which has neurotrophic activity and has obvious neurite growth-promoting effect on PC12 cells.

Source: Hericium erinaceus (Bull. Ex Fr.)

Others  
Neurological, Eye or Ear Disease  
/
HY-P1052A Myelin Basic Protein(87-99) TFA
Myelin Basic Protein(87-99) TFA is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) TFA causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS).
PKC  
Inflammation or Immune System Disease  
/
HY-13010S Laquinimod-d5
Laquinimod-d5 (ABR-215062-d5) is deuterium labeled Laquinimod. Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator that prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing-remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research.
Isotope-Labeled Compounds   NF-κB   Apoptosis  
Inflammation or Immune System Disease  
/
HY-W133935S Diethylenetriaminepentaacetic acid-13C5 pentasodium
Diethylenetriaminepentaacetic acid-13C5 pentasodium is the 13C-labeled Diethylenetriaminepentaacetic acid pentasodium (HY-W133935). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide.
Isotope-Labeled Compounds  
/
HY-W035399S D-Lysine-d8 dihydrochloride
D-Lysine-d8 dihydrochloride is the d8-labeled D-Lysine (HY-Y1091). D-Lysine is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine can be used in research related to cancer and diabetes.
Isotope-Labeled Compounds   Drug Isomer  
Cancer   Glucose Metabolism  
/
HY-P99822 Recaticimab
Recaticimab (SHR-1209) is a humanized IgG1 mAb that selectively targets PCSK9. Recaticimab reduces low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB), triglyceride (TG), and lipoprotein(a) levels. Recaticimab can be used for hyperlipidemia research.

Species: Human

PCSK9  
Hyperlipidemia  
/
HY-P99855 Divozilimab
Divozilimab (BCD-132) is a humanised monoclonal antibody against CD20 (CD20). Divozilimab can be used for multiple sclerosis research.

Species: Human

CD20  
Inflammation or Immune System Disease  
/
HY-P3828 Biotin-myelin basic protein (94-102)
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-B1804S2 Tricaprilin-d15
Tricaprilin-d15 (Trioctanoin-d15) is the deuterium labeled Tricaprilin (HY-B1804). Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT).
Isotope-Labeled Compounds   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-W539893 NODAGA-tris(t-Bu ester)
NODAGA-tris(t-Bu ester) (NODAG) is a NODAGA derivative. NODAGA-tris(t-Bu ester) can be used to label peptides, antibodies, etc., and subsequently radiolabeled for PET imaging.
Biochemical Assay Reagents  
Cancer  
/
HY-B1620E Polyvinylpyrrolidone K60
Polyvinylpyrrolidone K60 is one of the polymers in pharmaceutical preparations. Polyvinylpyrrolidone K60 promotes amorphous dispersion and inhibits crystallization of the drug.
Biochemical Assay Reagents  
/
HY-W019950 Chromium(Ⅲ) potassium sulfate dodecahydrate (98%)
Chromium(Ⅲ) potassium sulfate dodecahydrate (98%) (Chromic potassium sulfate (98%); Chrome alum (98%)), can be used as a fixative for microscopic analysis. Chromium(Ⅲ) potassium sulfate dodecahydrate (98%) is a kind of biological materials or organic compounds that are widely used in life science research.
Biochemical Assay Reagents  
/
HY-W008865 PIPES sesquisodium
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5.
Biochemical Assay Reagents  
/
HY-N0406 2"-O-beta-L-galactopyranosylorientin
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect.
P-glycoprotein  
Inflammation or Immune System Disease  
/
HY-Y0399S L-Norvaline-d5
L-Norvaline-d5 is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.
Isotope-Labeled Compounds   Amyloid-β   TNF Receptor   Arginase  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-W070306 PDK1-IN-1
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor. PDK1-IN-1 is also useful as inhibitor of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. PDK1-IN-1 selectively inhibits microtubule affinity regulating kinase (MARK). PDK1-IN-1 can be used for researches of myeloproliferative disorders, cancer and Alzheimer's disease.
PDK-1   FGFR   Wee1   MARK  
Lung Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Alzheimer's Disease   Obesity  
/
HY-P991704 Moponetug
Moponetug (PRX-005), an anti-microtubule binding region (MTBR) tau monoclonal antibody, is a humanized monoclonal tri-epitopic antibody. Moponetug binds with high affinity to the R1, R2, and R3 repeats in the MTBR region of tau, and targets both 3R and 4R tau isoforms. Moponetug can be used for the study of Alzheimer’s disease.

Species: Human

Tau Protein  
Alzheimer's Disease  
/
HY-D2645 Cy5 HA (MW 100000)
Cy5 HA (MW 100000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 100000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-W012382R N-Acetyl-L-tyrosine (Standard)
N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine (HY-W012382). This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer.
Reference Standards   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-N8693 Withanoside IV
Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19).
COX   Amyloid-β   Sirtuin   Reactive Oxygen Species (ROS)   Apoptosis   SARS-CoV  
SARS-CoV-2 Infection   Alzheimer's Disease  
/
HY-D2647 Cy5 HA (MW 500000)
Cy5 HA (MW 500000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 500000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-101183 THK5351
THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-50682S Azeliragon-d9
Azeliragon-d9 (TTP488-d9) is the deuterium labeled Azeliragon (HY-50682). Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB).
Isotope-Labeled Compounds   Amyloid-β  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P991577 DS-8895
DS-8895(DS-8895A) is an anti-EphA2 monoclonal antibody with specific binding to EphA2 receptors and EphA2-expressing cells. DS-8895, when conjugated with 89Zr, 111In, or 125I, supports molecular imaging of EphA2 expression in xenograft models. DS-8895 allows noninvasive measurement of EphA2 expresssion in tumors in vivo..

Species: Human

Ephrin Receptor  
Cancer  
/
HY-B0144AS1 Pitavastatin-d5 sodium
Pitavastatin-d5 (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.
Apoptosis   Mitophagy   HMG-CoA Reductase (HMGCR)   Autophagy  
Cancer   Metabolic or Endocrine Disease  
/
HY-D0948 Celestine Blue
Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen.
Fluorescent Dye  
Infection  
/
HY-128417A alpha-D-glucose hydrate
alpha-D-glucose hydrate is a monosaccharide and the most common form of glucose. It is a monosaccharide, which means it cannot be broken down into simpler sugars. alpha-D-glucose plays a vital role in energy metabolism and is the primary source of energy for many cells in the body. It is also a building block of larger carbohydrates such as starch and glycogen. The "α" prefix refers to the orientation of the hydroxyl group attached to the first carbon atom. Alpha-D-glucose exists in solution as a hydrate, which means it is bound to water molecules.
Biochemical Assay Reagents  
/
HY-D2640 Cy5 HA (MW 5000)
Cy5 HA (MW 5000) is a hyaluronic acid labeled with CY5 (HY-D0821). Cy5 HA (MW 5000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 633/670 nm).
Fluorescent Dye  
/
HY-W009300S 4-Hydroxyestrone-d4
4-Hydroxyestrone (4-OHE1)-d4 is the deuterium labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease.
Endogenous Metabolite   Isotope-Labeled Compounds   Estrogen Receptor/ERR   Sirtuin   MDM-2/p53   PDI   Ferroptosis   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-W012382S N-Acetyl-L-tyrosine-d3
N-Acetyl-L-tyrosine-d3 is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-P10887 Pegevongitide
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.
Tie   ANGPTL   SARS-CoV   Aquaporin   TNF Receptor   PAI-1   CXCR   P-selectin  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   SARS-CoV-2 Infection  
/
HY-W016371 3,4,5-Trichloropyridine
3,4,5-Trichloropyridine is a chlorinated pyridine compound and also serves as an internal standard for quantitative proton nuclear magnetic resonance spectroscopy.
Biochemical Assay Reagents  
/
HY-A0104B HPMC (Type I,Viscosity:100mPa.s)
HPMC (Type I, Viscosity: 100 mPa·s) is a nonionic polymer obtained via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, including the diffusion of drugs within the hydrated matrix and the polymer relaxation process.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-W130177 Iodocholine iodide
Iodocholine iodide is a non-toxic, metabolizable "green" catalyst that can catalyze the free radical polymerization of functional polymers. Iodocholine iodide is also the non-radioactive iodide of Carbon-11 choline. C-11 Choline can be used in PET imaging and non-informative bone scintigraphy, CT or MRI to monitor various types of cancer.
Biochemical Assay Reagents  
Cancer  
/
HY-W004284R Heptadecanoic acid (Standard)
Heptadecanoic acid (Standard) is the analytical standard of Heptadecanoic acid. This product is intended for research and analytical applications. Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis[1].
Reference Standards   Apoptosis   PI3K   Akt  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-17363R Dimethyl fumarate (Standard)
Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.
Reference Standards   Keap1-Nrf2   Reactive Oxygen Species (ROS)   HIV   Autophagy   Endogenous Metabolite  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
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HY-D0889R Glycylglycine (Standard)
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
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HY-34408 6-Methoxy-1-tetralone
6-Methoxy-1-tetralone is a tetralone derivative and core structure for synthesis of acetylcholinesterase and butyrylcholinesterase inhibitors. 6-Methoxy-1-tetralone can be used for the research of alzheimer’s disease.
Drug Isomer   Cholinesterase (ChE)  
Alzheimer's Disease  
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HY-Y1804 D-Lysine monohydrochloride
D-Lysine monohydrochloride is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine monohydrochloride is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine monohydrochloride blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine monohydrochloride specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine monohydrochloride can be used in research related to cancer and diabetes.
Drug Isomer  
Cancer   Glucose Metabolism  
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HY-W674241 4-Ethylphenyl sulfate
4-Ethylphenyl sulfate is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice.

Source: goat urine

Endogenous Metabolite   Apoptosis   Bcl-2 Family   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease  
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HY-P991319 TAB-004
TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.

Species: Human

Others  
Pancreatic Cancer   Triple-Negative Breast Cancer  
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HY-P99746 Murlentamab
Murlentamab (3C23K; GM102) is a humanized anti-AMHRII antibody. AMHRII is the anti-Müllerian hormone receptor. Murlentama significantly promotes macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Murlentama stimulates pro-inflammatory and anti-tumor internal environment, recruits and activates T cells. Murlentama suppresses tumors growth by inducing naïve macrophage orientation and promoting tumor-associated macrophage (TAM) reprogramming.

Species: Human

TGF-β Receptor  
Cancer   Inflammation or Immune System Disease  
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HY-P991373 APNmAb005
APNmAb005 is a human monoclonal antibody (mAb) targeting MAPT/Tau/PHF-tau. APNmAb005 blocks tau seeding in vitro and rescues neuronal loss in rTG4510 mice. APNmAb005 can be used in Alzheimer’s disease (AD) research.

Species: Human

Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-106594B Prussian blue soluble
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI).
Bacterial  
Cancer  
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HY-P99793 Orticumab
Orticumab (MLDL1278A) is an antibody targeting to oxidized or malondialdehyde-modified lipoprotein (LDL). Orticumab specifically inhibits oxidized low-density lipoproteins (oxLDL). Orticumab involves in modulation of autoimmune responses against oxLDL, improves atherosclerosis in animal model. Orticumab also can be used for research of psoriasis improvement.

Species: Human

LDLR  
Inflammation or Immune System Disease  
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HY-A0104E HPMC (Type II,Viscosity:100mPa.s)
HPMC (Hypromellose; (Hydroxypropyl)methyl cellulose; Celacol HPM 5000) (Type II,Viscosity:100mPa.s) is a non-ionic polymer obtained via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, including the diffusion of drugs in the hydrated matrix and the polymer relaxation process.
Environmental Pollutants   Biochemical Assay Reagents  
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HY-A0104I HPMC (Type II,Viscosity:100000mPa.s)
HPMC (Hypromellose; (Hydroxypropyl)methyl cellulose; Celacol HPM 5000) (Type II,Viscosity:100000mPa.s) is a non-ionic polymer obtained via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, including the diffusion of drugs in the hydrated matrix and the polymer relaxation process.
Biochemical Assay Reagents  
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HY-137840 Hippuryl-L-phenylalanine
Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity.
Carboxypeptidase  
Cancer  
/
HY-W284558 Sodium hexadecyl sulfate
Sodium hexadecyl sulfate is a long-chain anionic surfactant. Sodium hexadecyl sulfate can act as an interface-regulating substance to form a soft layer on the surface of carbon nanotubes, guide proteins to adsorb in the correct orientation with active sites facing outward through electrostatic interactions, and significantly enhance the activity of immobilized enzymes. Sodium hexadecyl sulfate can replace or supplement SDS (HY-Y0316) in capillary gel electrophoresis (CGE).
Biochemical Assay Reagents  
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HY-D0830 Calcein (tetraethyl ester)
Calcein tetraethyl ester is a tetraethylated derivative of calcein, with its core function serving as a live cell-specific fluorescent tracer. Calcein tetraethyl ester can diffuse between human periodontal ligament cells via gap junctions, thus enabling the evaluation of gap junction intercellular communication function, and its diffusion is enhanced under hydrogen peroxide induction. Calcein tetraethyl ester can be applied in the fields of cell biology and fluorescent labeling.
Fluorescent Dye  
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HY-D0805 Eosin 5-isothiocyanate
Eosin 5-isothiocyanate is an orange-red fluorescent and phosphorescent probe that reacts with amino groups. Eosin 5-isothiocyanate also acts as a photocatalyst. Eosin 5-isothiocyanate can be used for protein labeling, investigation of molecular rotational diffusion, and serves as a fluorescence resonance energy transfer (FRET) acceptor.
Fluorescent Dye  
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HY-17363S1 Dimethyl fumarate-d2
Dimethyl fumarate-d2 is the deuterium labeled Dimethyl fumarate. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.
Autophagy   HIV   Keap1-Nrf2   Endogenous Metabolite   Reactive Oxygen Species (ROS)  
Cancer  
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HY-P1707A Tau protein (592-597), human TFA
Tau protein (592-597), human TFA is a peptide fragment of human Tau protein. The dysfunction of Tau protein is involved in neurodegeneration and dementia.
Tau Protein  
Neurodegenerative Disease  
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HY-W283556 DO2A-tert-butyl ester
DO2A-tert-butyl ester is a bifunctional chelator (BFC) that can be used for the coupling of peptides and radionuclides. DO2A-tert-butyl ester can be used in the development of radionuclide imaging tracers.
Biochemical Assay Reagents  
Cancer  
/
HY-P991734 VHB937
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research.

Species: Human

TREM receptor   Syk   Calcium Channel  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
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HY-13212 (Z)-2-Decenoic acid
(Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development.

Source: Pseudomonas aeruginosa

Bacterial  
Cancer   Bacterial Infection   Lung Fibrosis  
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HY-B0594S Iohexol-d5
Iohexol-d5 is deuterium labeled Iohexol. Iohexol is a radiographic contrast agent and can be applied for myelography, computerized tomography?(cisternography, ventriculography) and MicroCT imaging in vivo.
Isotope-Labeled Compounds   Autophagy   Mitophagy  
Cancer  
/
HY-Y1091 D-Lysine
D-Lysine is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine can be used in research related to cancer and diabetes.
Drug Isomer  
Cancer   Glucose Metabolism  
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HY-D0721 6-CFDA
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes.
Fluorescent Dye  
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HY-W004284S1 Heptadecanoic acid-d33
Heptadecanoic acid-d33 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis.
Endogenous Metabolite  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P99213 Ozanezumab
Ozanezumab (GSK1223249) is a humanized, Fc-inactivated monoclonal antibody that targets the nervous system protein Nogo-A. Ozanezumab promotes neurite outgrowth and axonal regeneration by neutralizing Nogo-A signaling. Ozanezumab is used for research on neurodegenerative diseases such as amyotrophic lateral sclerosis and multiple sclerosis[1].

Species: Human

Others  
Amyotrophic Lateral Sclerosis   Multiple Sclerosis  
/
HY-W009081 Tricosanoic acid
Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1, which can activate hair growth. Tricosanoic acid (C23:0) has the activity of improving cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, participating in myelination and neuronal energy metabolism. Tricosanoic acid expression levels are low in the prefrontal cortex of Alzheimer's disease (AD) models; while better cognitive performance corresponds to higher serum concentration levels. Tricosanoic acid can be used as a biomarker for diseases related to cognitive decline.
Free Fatty Acid Receptor  
Neurodegenerative Disease  
/
HY-W127502 1-Hexadecyl lysophosphatidic acid
1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility.
Biochemical Assay Reagents  
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HY-P99648 Gosuranemab
Gosuranemab (BMS-986168; IPN007; BIIB092) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease.

Species: Human

Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-W250143 Toluidine blue (ZnCl2)
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.
Biochemical Assay Reagents  
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HY-159181 p-NCS-Bz-DOTA-GA
p-NCS-Bz-DOTA-GA is a bifunctional chelator. p-NCS-Bz-DOTA-GA can be used as a versatile linker in targeted molecular imaging for both PET/SPECT and MRI applications.
Biochemical Assay Reagents  
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HY-P99163 Tilavonemab
Tilavonemab (ABBV-8E12) is a humanized anti-tau monoclonal antibody that binds to amino acids 25-30 near the N-terminus of the tau protein. Tilavonemab can block the ability of human and mouse neurons to uptake tau aggregates. Tilavonemab can be used for research on Alzheimer’s disease and other tauopathies.

Species: Human

Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-P4704A α-Synuclein (61-95) (human) TFA
α-Synuclein (61-95) (human) TFA is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) TFA can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-113410 3-Methylglutaric acid
3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
Na+/K+ ATPase   Mitochondrial Metabolism   Reactive Oxygen Species (ROS)  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation   Parkinson's Disease  
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HY-113262 8-Hydroxyguanosine
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome.
Endogenous Metabolite   Interleukin Related  
Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease  
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HY-W066890 4-Nitrocatechol
4-Nitrocatechol is a Lipoxygenase inhibitor. 4-Nitrocatechol can serve as a ligand to stabilize the formation of metal complexes. As a (+) MALDI matrix, 4-Nitrocatechol significantly enhances the MALDI-MS detection and imaging of low-molecular-weight compounds in animal and plant tissue sections.
Lipoxygenase   Biochemical Assay Reagents  
/
HY-W010514 trans-Cyclohexane-1,2-diol
trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-113285 Ureidopropionic acid
Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria.
Oxidative Phosphorylation   Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
/
HY-P9949 Reslizumab
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with KD values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-W012634 Benzothiazole
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent.
Bacterial  
Inflammation or Immune System Disease   Bacterial Infection   Glucose Metabolism   Alzheimer's Disease  
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HY-P99317 Solanezumab
Solanezumab (LY-2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab binds to the mid-domain of monomeric amyloid-beta to slow brain amyloid accumulation. Solanezumab can be used for the research of Alzheimer’s disease.

Species: Human

Amyloid-β  
Alzheimer's Disease  
/
HY-P3507 Dalazatide
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
Potassium Channel  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P10936A AQP4 (201-220) TFA
AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica.
Aquaporin  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P3507A Dalazatide TFA
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
Potassium Channel  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W250110I Polyethylenimine (branched) (MW 10000)
Polyethylenimine (branched) (MW 10000) is a organic macromolecule with high cationic-charge-density potential. Polyethylenimine (branched) (MW 10000) can ensnare DNA as well as attach to cell membrane.
Biochemical Assay Reagents  
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HY-W007656 Cyclen
Cyclen is a macrocyclic tetraamine chelating agent. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions.
Biochemical Assay Reagents  
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HY-P9960 Ocrelizumab
Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC).

Species: Human

CD20  
Inflammation or Immune System Disease  
/
HY-NP007 Myoglobin
Myoglobin is an oxygen-binding heme protein. Myoglobin scavenges ROS via its peroxidase activity, and binds to and inactivates NO in the heart and oxidative skeletal muscle. Myoglobin stores, buffers and facilitates intracellular oxygen diffusion, maintains aerobic metabolism under hypoxic/anoxic conditions, and provides oxygen supply support for mitochondria. Myoglobin alleviates oxidative stress, protects cardiac function and affects cardiac redox pathways. Myoglobin can be used in studies related to ischemia-reperfusion injury, oxidative stress-induced cardiac dysfunction and acute myocardial infarction.
Reactive Oxygen Species (ROS)   NO Synthase  
Ischemia-Reperfusion Injury   Myocardial Infarction  
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HY-Y0399 L-Norvaline
L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.
Amyloid-β   TNF Receptor   Arginase  
Metabolic or Endocrine Disease   Breast Cancer   Alzheimer's Disease   Lung Fibrosis  
/
HY-W012382 N-Acetyl-L-tyrosine
N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer.
Endogenous Metabolite  
Colorectal Cancer   Glucose Metabolism  
/
HY-P1389 Neuropeptide S (human)
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.
Neuropeptide S Receptor  
Neurological, Eye or Ear Disease  
/
HY-76440 3-Oxetanone
3-Oxetanone (Oxetan-3-one) is a four-membered cyclic ketone and strained cyclic ether derivative with measurable molecular g-value, magnetic susceptibility anisotropy and molecular quadrupole moment. 3-Oxetanone acts not only as a hydrogen bond acceptor, a tetrel donor and a weak hydrogen bond acceptor, but also forms a classic O-H···O hydrogen bond with H2O via the ether oxygen atom. Alternatively, it forms a C···O tetrel bond with formaldehyde using its carbonyl group as a tetrel donor, while acting as a proton acceptor to form a C-H···O weak hydrogen bond with formaldehyde. 3-Oxetanone can be used to prepare various oxetanes.
Biochemical Assay Reagents  
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HY-P2280 TAT-P110
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1.
Dynamin  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-W094758A 4-Di-1-ASP
4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λex /λem = 475/606 nm) .
Fluorescent Dye  
Cancer  
/
HY-157839 PROTAC α-Synuclein/Tau degrader 1
PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with KDs of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803)).
PROTACs   α-synuclein   Tau Protein  
Parkinson's Disease  
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HY-NP0204 MSA Protein
MSA Protein (Mouse Serum Albumin) is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD).
ELOVL   Apoptosis   NOD-like Receptor (NLR)   Caspase   Tau Protein  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
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HY-W015229S 3-Indolepropionic acid-d2
3-Indolepropionic acid-d2 is the deuterium labeled 3-Indolepropionic acid. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Isotope-Labeled Compounds   Endogenous Metabolite   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
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HY-P99471 Bepranemab
Bepranemab is a humanized IgG4 monoclonal antibody that binds to the central region of tau protein. Bepranemab inhibits the seeding, aggregation of pathological tau protein and the spread of tau pathology to distal brain regions. Bepranemab is applicable to research related to Alzheimer's disease.

Species: Human

Tau Protein  
Alzheimer's Disease  
/
HY-138669 C004019
C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases.
PROTACs   Tau Protein  
Alzheimer's Disease  
/
HY-134850 QC-01–175
QC-01-175 is a Tau PROTAC degrader, with Kd values of 1.2 μM, 1.7 μM and 2.5 μM for wild-type, A152T mutant and P301L mutant tau-441 proteins, respectively. QC-01-175 binds to both Tau and CRBN, triggering ubiquitination and proteasomal degradation of Tau. QC-01-175 preferentially targets disease-associated Tau proteins in frontotemporal dementia. QC-01-175 inhibits MAO activity, with an IC50 of 8.56 μM. QC-01-175 suppresses the elevation of ROS levels. QC-01-175 can be used in studies related to frontotemporal dementia and amyotrophic lateral sclerosis.
PROTACs   Tau Protein   Monoamine Oxidase   Reactive Oxygen Species (ROS)  
Amyotrophic Lateral Sclerosis  
/
HY-130750 Phycocyanobilin
Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease.

Source: Spirulina platensis

Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease  
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HY-P99289 Epratuzumab
Epratuzumab (Antibody hLL 2) is an anti-CD22 IgG1 monoclonal antibody. Epratuzumab is also a tumor-imaging agent and an immunomodulatory agent. Epratuzumab can induce CD22 phosphorylation. Epratuzumab has been used to research non-Hodgkin’s lymphomas (NHL) and certain autoimmune diseases.

Species: Human

CD22  
Leukemia/Lymphoma/Myeloma   Autoimmune Disease  
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HY-N6664 Gum arabic
Gum Arabic is an orally active complex branched polysaccharide. Gum Arabic can be isolated from the Acacia senegal tree. Gum Arabic upregulates the expression of maturation markers (CD86, CD40, and CD54), promotes ERK1/2 phosphorylation, and inhibits Apoptosis. Gum Arabic exhibits antimalarial effects against Plasmodium berghei ANKA. Gum Arabic exhibits hepatoprotective, renal, and cardiovascular protective activities. Gum Arabic improves obesity. Gum Arabic is commonly used as a stabilizer and thickener. Gum Arabic can be used in the research of brain tumor imaging.
Parasite   Transmembrane Glycoprotein   PERK   Apoptosis   Free Radical Scavengers  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Bacterial Infection  
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HY-112624L Dextran T10 (MW 10,000)
Dextran T10 (MW 10,000) (Dextran 10) is a dehydrated glucose polymer with an average molecular weight of 10,000. Dextran T10 (MW 10,000) is composed of repeated glucose units, and it has abundant hydroxyl (-OH) groups, which can be used as a natural "magnetic marker" for chemical exchange saturation transfer (CEST) MRI imaging.
Biochemical Assay Reagents  
Cancer  
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HY-W040201 CHAPSO
CHAPSO is a bile derivative. CHAPSO reduces protein adsorption, improves the cryo-EM imaging quality. CHAPSO can be used as a detergent, or as the membrane protein solubilization and reconstruction reagent in membrane protein structural studies.
Biochemical Assay Reagents  
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HY-128850 N-Acetyl-D-mannosamine
N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders.
Endogenous Metabolite  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
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HY-59291 Levacetylleucine
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention.
Amino Acid Derivatives  
Neurodegenerative Disease   CNS Infection   Traumatic Brain Injury  
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HY-W007432 RuPhos
RuPhos is a Buchwald ligand. In aqueous Suzuki-Miyaura catalytic transfer polymerization, RuPhos forms inactive Pd (RuPhos)2 with palladium and inhibits diffusion to improve polymerization controllability. RuPhos additional addition in anhydrous Kumada polymerization exacerbates catalyst deactivation and chain transfer, significantly impairing polymerization control.
Biochemical Assay Reagents  
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HY-110252 Salvinorin B
Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC50 of 248 nM and Ki of 2.95 μM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for the researches of inflammation, immunology and neurological disease, such as neuropathic pain, multiple sclerosis and anxiety.
Opioid Receptor  
Inflammation or Immune System Disease   Depression   Pain  
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HY-P990774 Verekitug
Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease.

Species: Human

Interleukin Related  
Rhinosinusitis   Chronic Obstructive Pulmonary Disease   Asthma  
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HY-P99486 Briakinumab
Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
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HY-W011696 Oleylamine, 80-90%
Oleylamine, 80-90% (cis-1-Amino-9-octadecene, 80-90%) is a multifunctional reagent used for metal ion coordination and nanoparticle surface modification, and acts as a solvent, surfactant and reducing agent in the synthesis of metal oxide nanoparticles. Oleylamine, 80-90% regulates nanoparticle morphology, magnetization intensity and water proton relaxation rate via thiol-ene "click" reaction, and enhances the colloidal stability of nanoparticles in organic reagents. Oleylamine, 80-90% is mainly used in research and applications in fields such as nanomaterial synthesis, biomedical imaging (MRI contrast agents, fluorescent probes), cancer cell targeting and drug delivery.
Environmental Pollutants   Biochemical Assay Reagents  
Cancer  
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HY-P99391 Telisotuzumab
Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers.

Species: Human

c-Met/HGFR   Apoptosis  
Gastric Cancer   Respiratory Cancer  
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HY-P701094 Apolipoprotein E/APOE2 Protein, Human (R154S, R176C, HEK293, C-His)
Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (R154S, R176C, HEK293, C-His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with C-6*His labeled tag and R154S, R176C mutation.

Species: Human; Source: HEK293

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HY-P701025 MDK/Midkine Protein, Mouse (His)
Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors.It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration.MDK/Midkine Protein, Mouse (His) is the recombinant mouse-derived MDK/Midkine protein, expressed by E.coli , with N-His labeled tag.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors

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HY-P70245 Ferritin light chain/FTL Protein, Human (His)
Ferritin light chain/FTL protein is pivotal in iron homeostasis, storing iron in a soluble, non-toxic form and delivering it to cells. In kidney development, FTL mediates iron uptake in capsule cells, crucial for organogenesis. Structurally, FTL, an oligomer with light and heavy subunits forming a spherical shell, facilitates iron entry through pores. Mutations in the C-terminus disrupt pore formation, impacting iron accumulation. Ferritin light chain/FTL Protein, Human (His) is the recombinant human-derived Ferritin light chain/FTL protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P71907 Pleiotrophin Protein, Human
Pleiotrophin is a secreted growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors to influence a variety of cellular processes. It binds to chondroitin sulfate (CS) groups, regulates proliferation, survival and differentiation, and inhibits long-term synaptic potentiation of neurons. Pleiotrophin Protein, Human is the recombinant human-derived Pleiotrophin protein, expressed by E. coli , with tag free. The total length of Pleiotrophin Protein, Human is 136 a.a., with molecular weight of ~15.3 kDa.

Species: Human; Source: E. coli

Cytokines and Growth Factors

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HY-P705520 Ftl1 Protein, Mouse (His)
Ferritin light chain 1 (FTL1) is an iron-associated protein that acts as a pro-aging neuronal factor, impairing cognitive function. Ftl1, Mouse (His) is a recombinant mouse Ftl1 protein expressed by E. coli and tagged with C-6*His.

Species: Mouse; Source: E. coli

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HY-P72172 DENR Protein, Human (His-SUMO)
DENR proteins play a key role in the translation process, participating in mRNA scanning and start codon recognition. It crucially promotes the recruitment of aminoacylated initiator tRNA to the 40S ribosomal P site during translation initiation. DENR Protein, Human (His-SUMO) is the recombinant human-derived DENR protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Human; Source: E. coli

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HY-P701024 MDK/Midkine Protein, Human (Biotinylated, His-Avi)
Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. MDK/Midkine Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived MDK/Midkine protein, expressed by E. coli , with C-Avi, N-His labeled tag.

Species: Human; Source: E. coli

Cytokines and Growth Factors Biotinylated Proteins

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HY-P704979 Apolipoprotein E/APOE3 Protein, Human (Biotinylated, R154S, HEK293, His-Avi)

Species: Human; Source: HEK293

Biotinylated Proteins

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HY-P83754 beta Amyloid 1-42 Antibody (YA3555)
beta Amyloid 1-42 Antibody (YA3555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-42.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81166 ox-LDL Antibody
ox-LDL Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ox-LDL.

Host: Rabbit; Reactivity: Human

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83717 LDLR Antibody (YA3452)
LDLR Antibody (YA3452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LDLR.

Host: Rabbit; Reactivity: Human, Mouse

Recombinant Antibodies Primary Antibodies

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HY-P83753 beta Amyloid 1-40 Antibody (YA3554)
beta Amyloid 1-40 Antibody (YA3554) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-40.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81172 LOX 1 Antibody
LOX 1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to LOX 1.

Host: Rabbit; Reactivity: Human, Rat, Rabbit

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80212 LRP6 Antibody (YA708)
LRP6 Antibody (YA708) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LRP6.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86713 ox-LDL Antibody (YA6405)
ox-LDL Antibody (YA6405) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ox-LDL.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P83753A beta Amyloid 1-40 Antibody (YA3554)(PBS only)
beta Amyloid 1-40 Antibody (YA3554) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-40.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83754A beta Amyloid 1-42 Antibody (YA3555)(PBS only)
beta Amyloid 1-42 Antibody (YA3555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-42.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83755 beta Amyloid Antibody (YA3556)
beta Amyloid Antibody (YA3556) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83755A beta Amyloid Antibody (YA3556)(PBS only)
beta Amyloid Antibody (YA3556) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87726 LDLR Antibody (YA7411)
LDLR Antibody (YA7411) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to LDLR.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810758 Phospho-LRP6 (Ser1490) Antibody (YA10001)
Phospho-LRP6 (Ser1490) Antibody (YA10001) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Phospho-LRP6 (Ser1490).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811715 Nmi Antibody (YA10186)
Nmi Antibody (YA10186) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to Nmi.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86713A ox-LDL Antibody (YA6405)(PBS only)
ox-LDL Antibody (YA6405) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ox-LDL.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P88451 MRI1 Antibody (YA8135)
MRI1 Antibody (YA8135) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MRI1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P88451A MRI1 Antibody (YA8135)(PBS only)
MRI1 Antibody (YA8135) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to MRI1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P810456 PSD93 Antibody
PSD93 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PSD93.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-K0239 Streptavidin-Binding Peptide Tag Agarose

MCE Streptavidin-Binding Peptide Tag Agarose is composed of a highly cross-linked 4% agarose matrix with an engineered streptavidin mutant protein chemically immobilized onto the matrix in a highly oriented and high-density manner. It is suitable for the efficient purification of recombinant proteins carrying a streptavidin-binding peptide tag from a variety of expression systems, including E.coli, yeast, insect cells, and mammalian cells.

Protein Biology Protein Purification Agarose Beads

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HY-K0355 Mouse CD3 Cell Depletion Magnetic Beads (Positive Selection)

MCE Mouse CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-mouse CD3 antibodies, enabling the specific binding and magnetic removal of CD3+ cells from single-cell suspensions derived from mouse spleen and other tissues. This allows efficient enrichment of the non-CD3+ cell population.

Cell Biology Cell Isolation

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HY-K0356 Human CD3 Cell Depletion Magnetic Beads (Positive Selection)

MCE Human CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-human CD3 antibodies, enabling the specific binding and magnetic removal of CD3+ cells from single-cell suspensions derived from human peripheral blood mononuclear cells (PBMCs) or human peripheral blood leukocytes (WBCs). This allows efficient enrichment of the non-CD3+ cell population.

Cell Biology Cell Isolation

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HY-K0358 Human CD66b+ Cell Positive Selection Kit

MCE Human CD66b+ Cell Positive Selection Kit is designed for the efficient isolation of CD66b+ cells from human peripheral blood single-cell suspensions. CD66b+ cells are first specifically labeled with the CD66b Capture Antibody and subsequently captured using Releasable Magnetic Beads. Following magnetic separation, the beads are detached from the cell surface using Magnetic Beads Release Buffer, resulting in highly purified CD66b+ cells free of residual magnetic bead labeling.

Cell Biology Cell Isolation

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HY-K0360 Mouse CD4+ CD25+ Regulatory T Cell Positive Selection Kit

MCE Mouse CD4+ CD25+ Regulatory T Cell Positive Selection Kit is designed for the isolation of CD4+ CD25+ regulatory T cells (Tregs) from mouse splenic single-cell suspensions. The kit utilizes a two-step isolation strategy. First, CD4 Enrichment Beads are used to deplete non-target cells and enrich CD4+ T cells. Subsequently, CD25 Capture Antibody specifically binds to CD25+ cells, which are then captured by Releasable Magnetic Beads. Following isolation, the magnetic beads are gently detached from the cell surface using Magnetic Beads Release Buffer, yielding label-free CD4+ CD25+ regulatory T cells with no residual magnetic beads.

Cell Biology Cell Isolation

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HY-K0608 Masson Staining Kit

MCE Masson Staining Kit can simultaneously stain various tissue components, such as cell nuclei, collagen fibers, and muscle fibers. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Cell Biology Cell Analysis Staining Kit

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HY-K0609 Modified Masson Staining Kit

MCE Modified Masson Staining Kit employs Celestine Blue hematoxylin for light nuclear staining, offering shorter differentiation time compared to conventional methods. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Cell Biology Cell Analysis Staining Kit

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HY-K2035 Fluc mRNA (N1-Me-pUTP)

MCE Fluc mRNA (N1-Me-pUTP) is widely used for evaluating lipid nanoparticle (LNP) delivery efficiency, validating mRNA transfection reagents, assessing in vitro and in vivo mRNA expression, IVIS bioluminescence imaging, and screening novel nucleic acid delivery systems. It is commonly used as a positive control or reporter mRNA.

Cell Biology Cell Culture Cell Transfection

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HY-K3013 Bi-27 Supplement (50×), Sterile

This product is the serum-free B-27 Supplement, the most widely cited neuronal culture supplement. It is an optimized formulation designed to support both low- and high-density growth, as well as short- and long-term viability of embryonic neurons. This product is formulated with water-for-injection. The 10 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K3013A Bi-27 Serum-free Supplement (50×)

MCE Bi-27 Serum-free Supplement (50×) can be used to support the low- or high-density growth and short- or long-term viability of embryonic. This product is formulated with basal culture medium. The 10 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K3014 Bi-27 Supplement (50×), Vitamin A-Free, Sterile

This product is serum-free and vitamin A-free.It is a customized variant of the standard Bi-27 formulation with vitamin A removed as a supplement for neuronal cell culture to support the low- or high-density growth and short- or long-term viability of embryonic. This product is formulated with water-for-injection. The 10 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K3014A Bi-27 Serum-free Supplement (50×), Vitamin A-Free

MCE Bi-27 Serum-free Supplement (50×), Vitamin A-Free can be used to support the low- or high-density growth and short- or long-term viability of embryonic. This product is formulated with basal culture medium. The 10 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K3015 Density Gradient Medium (Iodixanol)

Density Gradient Medium, also known as Iodixanol, is a low osmolality, non-ionic, iodinated density gradient medium.

Cell Biology Cell Culture Cell Isolation Cell Separation Media

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HY-K3023 Cell Separation Medium (Density Gradient)

MCE Cell Separation Medium (Density Gradient) is a low-density gradient medium characterized by its broad applicability, operational simplicity, and gentle separation performance.It is primarily composed of silica particles (15-30 nm in diameter) coated with a monolayer of polyvinylpyrrolidone (PVP).

Cell Biology Cell Culture Cell Isolation Cell Separation Media

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HY-K3035 G-5 Supplement (100×)

MCE G-5 Supplement (100×) is a serum-free, chemically defined cell culture supplement developed based on the classic Bottenstein G-5 formulation. It is suitable for the culture of primary glial cells and neural cells with myelination properties. This supplement contains growth factors, hormones, insulin, transferrin, and other components related to cell growth and maintenance.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K3036 IMDM (Iscove's Modified Dulbecco's Medium)

MCE IMDM (Iscove's Modified Dulbecco's Medium) is an enriched formulation modified from DMEM, containing high concentrations of glucose, sodium pyruvate, amino acids, vitamins, HEPES buffer, selenium, and other essential nutrients. It is designed to meet the nutritional requirements for rapid cell proliferation and high-density culture, supporting a variety of cell types, including Jurkat cells, COS-7 cells, and macrophages. The product specifications are based on the 500 mL format, and larger volume packages are provided as multiples of this standard specification.

Cell Biology Cell Culture Basal Cell Culture Media

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HY-K3050 Pyrogen-Free Water

MCE Pyrogen-Free Water is sterile-filtered ultrapure water with a bacterial endotoxin level of ≤0.005 EU/mL. It is free of nucleases, proteases, and other interfering substances. It is suitable for procedures sensitive to endotoxin contamination, including the dilution of working standards and test samples for bacterial endotoxin testing and the preparation of cell culture media and buffers.

Cell Biology Cell Analysis Endotoxin Detection

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HY-K3120 Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads)

MCE Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads) utilizes a magnetic bead-based method for the isolation and purification of exosomes. The underlying principle is based on the charge-dependent interaction between exosomes and functional polymers on the surface of the magnetic beads under an optimized buffer system, enabling selective adsorption of exosomes. Subsequent adjustment of the ionic strength and pH of the buffer promotes the gentle dissociation of exosomes from the magnetic beads, thereby enabling efficient exosome isolation and purification while maintaining high vesicle integrity and low impurity carryover.

Cell Biology Cell Analysis Exosome Isolation, Purification and Detection

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HY-KD1004A Vari Fluor 4-colour Multiple Fluorescent Staining Kit-1 (For all samples)
Multiplex immunohistochemistry is also known as Tyramide Signal Amplification (TSA, Tyramide dignal amplification). It has been used for more than 20 years as an enzymatic assay for high-density in situ labelling of target proteins or nucleic acids by horseradish peroxidase (HRP). The method is based on multiple cis-immunostaining with tyramide signal amplification, which allows the detection of multiple target sites in cell or tissue samples in situ, and elucidation of their interaction mechanism through the study of the combination and positional relationship of these target sites.

Protein Biology Multiple Fluorescent Staining

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Targets/Pathways

Keywords

diffusion MRI | diffusion magnetic resonance imaging | tissue microstructure | diffusion tensor imaging | DTI | diffusion kurtosis imaging | DKI | neurite orientation dispersion and density imaging | NODDI | fractional anisotropy | microscopic fractional anisotropy | neurite density | orientation dispersion | white matter | axonal density | myelination | free-water imaging | neurodegeneration | imaging biomarkers | Alzheimer’s disease | multiple sclerosis