Topics

Ventral Hippocampus Integrates Internal and External Signals to Regulate Motivated Behavior

Intercellular Communication & Diseases Chronic Inflammation Metabolic Diseases Neurodegeneration

The ventral hippocampus (vHPC), corresponding broadly to the anterior hippocampal domain in primates, has historically been distinguished from dorsal hippocampal circuits by its stronger association with stress, emotion, and affect rather than primarily spatial-cognitive functions. Contemporary work extends this “emotional hippocampus” concept by defining the vHPC, particularly ventral CA1 (vCA1), as a network that links salient external stimuli with internal motivational drive states and transforms this information into adaptive behavioral selection. This framework reflects growing recognition that heterogeneous vHPC cell types, inputs, and outputs coordinate both positively and negatively motivated behaviors rather than serving a single emotional function. Pathway-specific studies further show that vHPC projections participate in emotional memory, social memory, instrumental actions, object-related memory, feeding, and anxiety-like behavior, establishing this region as an interface between memory, internal state, environmental context, and motivated action. Hippocampal control of feeding illustrates this integrative function especially clearly because contextual and mnemonic information interacts with physiological energy signals to influence appetitive and ingestive behavior. Mechanistically, vHPC output is organized through projection-specific circuits rather than a one-pathway-one-function architecture[1][2][3][4].

A monosynaptic glutamatergic vCA1-to-medial prefrontal cortex pathway suppresses food-motivated behavior through vCA1 glucagon-like peptide-1 receptor signaling; GLP-1 receptor activation reduces food intake and impulsive responding through downstream NMDA receptor signaling in the medial prefrontal cortex. Ventral subiculum neurons expressing melanocortin-4 receptor that project to nucleus accumbens shell also collateralize to arcuate, ventromedial, and dorsomedial hypothalamic nuclei, and their activation increases motivation for palatable food without noticeably changing homeostatic feeding. The vCA1-nucleus accumbens shell pathway additionally regulates decisions when reward and punishment information conflict: pathway inhibition increases decision time and avoidance bias and reduces social-novelty seeking. Glutamatergic vHPC projections also directly engage nucleus accumbens cholinergic interneurons, and these projections are strongly altered in a mouse model displaying depressive-like phenotypes. Recent work further identifies a sex-specific vHPC-accumbens shell circuit controlling food-directed impulsive action in male rats. These circuits connect vHPC biology to research on psychiatric and metabolic dysfunction without yet establishing the vHPC itself as a validated clinical drug target[2][5][6][7][8][9].

In addiction-related research, inhibiting the vCA1-to-nucleus accumbens core projection reduces retrieval and expression of cocaine-conditioned place preference, identifying this pathway as a circuit substrate for drug-associated memory retrieval. Depression-related models reveal reduced and functionally altered vHPC glutamatergic input to nucleus accumbens cholinergic interneurons, while metabolic studies implicate ventral-subiculum MC4R signaling in food reward and energy balance. Major unresolved questions concern how distinct vCA1 neuronal ensembles encode salient stimuli, how internal states modify these representations, and how ensembles route information toward different downstream targets. The observation that individual vHPC projections can participate in several behaviors also challenges simple anatomical assignment of single functions. Future work therefore needs circuit-, cell-type-, state-, and sex-specific resolution to determine when vHPC output promotes approach, avoidance, feeding, impulse control, social behavior, or memory-guided reward seeking, and whether these experimentally defined mechanisms can support therapeutically selective interventions without disrupting adaptive hippocampal functions.[2][3][5][6][7][8][9][10].

Articles

All
  • All
  • Scientific Reviews
  • EDM
  • Product Guides
  • Blog
Most Recent
  • Most Recent
  • Oldest

Products

All
  • All
  • Inhibitors & Agonists
  • Isotope-Labeled Compounds
  • Fluorescent Dye
  • Peptides
  • Recombinant Proteins
  • Antibodies
  • Screening Libraries
  • Kits
  • Inhibitory Antibodies
  • Reference Standards
  • Induced Disease Models Products
  • GMP Small Molecules
  • Biochemical Assay Reagents
  • Natural Products
Cat. No. Product Name Information Application Publication
HY-B2176B ATP dimagnesium
ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation. ATP dimagnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dimagnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
178
HY-B2176 ATP
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Source: widespread

Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
178
HY-B0345A ATP disodium salt
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.

Source: Widespread

Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
175
HY-W010735 ATP disodium salt hydrate
ATP (Adenosine 5'-triphosphate) disodium salt hydrate is a central component of energy storage and metabolism in vivo. ATP disodium salt hydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt hydrate can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt hydrate has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Source: widespread

Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
171
HY-B2176I ATP disodium salt, 100 mM Solution, PCR Grade
ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
168
HY-L078 Gut Microbial Metabolite Library
Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods. In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 475 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Metabolism Focused Libraries

85
HY-L134 Anti-Aging Natural Product Library
Aging is an unavoidable process, leading to cell senescence due to physiochemical changes in an organism. Aging cells cease to divide and drive the progression of illness through various pathways, resulting in the death of an organism ultimately. Anti-aging activities are primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. Natural products are known as effective molecules in anti-aging treatments, which delay the aging process through influencing several pathways and thus ensure an extended lifespan. MCE offers a unique collection of 193 natural products with validated anti-aging activity. MCE anti-aging natural product library is a useful tool for the study of aging-related diseases drugs and pharmacology.

Natural Product Screening Libraries Disease Focused Libraries

85
HY-L083 Anti-Cancer Metabolism Compound Library
Mutations in oncogenes and tumor suppressor genes can modify multiple signaling pathways and in turn cell metabolism, which facilitates tumorigenesis. The paramount hallmark of tumor metabolism is “aerobic glycolysis” or the Warburg effect, coined by Otto Warburg in 1926, in which cancer cells produce most of energy from glycolysis pathway regardless of whether in aerobic or anaerobic condition. Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside. The increased uptake of glucose is facilitated by the overexpression of several isoforms of membrane glucose transporters (GLUTs). Likewise, the metabolic pathways of glutamine, amino acid and fat metabolism are also altered. Recent trends in anti-cancer drug discovery suggests that targeting the altered metabolic pathways of cancer cells result in energy crisis inside the cancer cells and can selectively inhibit cancer cell proliferation by delaying or suppressing tumor growth. MCE provides a unique collection of 3,806 compounds which cover various tumor metabolism-related signaling pathways. These compounds can be used for anti-cancer metabolism targets identification, validation as well anti-cancer drug discovery.

Signaling Pathway Targeting Libraries

84
HY-L047 Endocrinology Compound Library
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function. The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease. MCE offers a unique collection of 908 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Disease Focused Libraries

83
HY-L074 Anti-Breast Cancer Compound Library
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 3,404 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Disease Focused Libraries

83
HY-L087 Anti-Obesity Compound Library
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 3,741 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Disease Focused Libraries

83
HY-L108 Antidepressant Compound Library
Depression is a serious global affective disorder and one of the most common neurological diseases whose clinical manifestations are low mood, loss of interest, anhedonia, loss of energy, and fatigue, people with major depressive disorder (MDD) can even have suicidal thoughts and behaviors. Currently available antidepressants have significant limitations, including a long time lag for a therapeutic response (weeks to months) and low response rates. This is particularly problematic for a disease with a high suicide rate. Therefore, the development of new antidepressant drugs is particularly urgent. MCE offers a unique collection of 3,059 compounds with antidepressant activities or targeting the unique targets of depression. MCE Antidepressant Compound Library is a useful tool for exploring the mechanism of depression and discovering new drugs for depression.

Disease Focused Libraries

83
HY-L165 Dopamine Receptor Compound Library
Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life. MCE designs a unique collection of 282 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Signaling Pathway Targeting Libraries

83
HY-L168 Extracellular Vesicles (EVs) Compound Library
Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells. MCE designs a unique collection of 707 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.

Signaling Pathway Targeting Libraries

83
HY-L202 Flavor Compound Library
Flavor is an expression of smell and taste that is achieved through a variety of chemical processes triggered by molecules. Food flavor is an important attribute of food quality and in some cases determines consumers' food preferences. In addition to playing a key role in taste and smell, flavor molecules can also be involved in regulating metabolism and have an impact on health. In daily life, flavor molecules have absolute application value in food and spices. In scientific research, the study of flavor molecules is helpful to reveal the relationship between food intake and taste perception. Research on the combination behavior of flavor and food components can explore the retention, release and perception of flavor molecules. Most importantly, while exploring multi-sensory flavor perception, the food industry can fully mobilize the enthusiasm of researching new strategies for delicious and healthy food design. Based on the FlavorDB database, collects and organizes 442 flavor molecules, which can be used in taste perception and other related studies.
83
HY-L204 Lactic Acid Metabolic Compound Library
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 582 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
83
HY-L219 Antimicrobial Peptides Library
Antimicrobial Peptides (AMPs), also known as antimicrobial peptides or antibiotic peptides, are a class of polypeptides encoded by specific genes in various biological cells and induced by external stimuli. They exhibit broad-spectrum bioactivity against bacteria, fungi, viruses, protozoa, and even tumor cells. AMPs serve as crucial effector molecules in the host's innate immune system.Due to their wide antimicrobial spectrum, low toxicity to normal cells of higher animals, high safety profile, low tendency to induce resistance, and additional benefits such as immune enhancement and antioxidant effects, antimicrobial peptides hold significant promise in new drug development. MCE offers 58 types of antimicrobial peptides, which can be applied in high-throughput screening for research in anti-infection therapies, immunotherapy, anticancer drug development, and agricultural disease control.
83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L942 Allosteric Modulator Fragment Library
Unlike highly conserved orthosteric sites, allosteric sites exhibit low conservation, high hydrophobicity, weak polarity, confined geometry, and dynamic cryptic properties. Rather than rigid keyhole-like cavities, they typically appear as flexible grooves, subunit interface clefts, or shallow depressions formed by protein conformational changes. Based on the dynamic, hydrophobic, and elongated nature of allosteric pockets, MCE has carried out targeted fragment modification and screening under strict physicochemical criteria: MW 120–280 Da, HBD ≤ 2, HBA ≤ 3, PSA 30–80 Ų, rotatable bonds ≤ 2, cLogP 1–3.5. High 3D diversity was further ensured by PMI analysis, yielding fragments with excellent shape complementarity to allosteric pockets. This library contains 1,800 structurally diverse, drug-like fragments, this library supports allosteric drug development and pocket optimization. It significantly improves screening hit rates and enables efficient, precise early-stage R&D of allosteric drugs.

Functional Fragment Libraries

83
HY-L944 MCE‑18 Novelty Focused Drug‑Like Library
MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity. According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs. MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat

Distinctive Diversity Libraries

83
HY-13443 Exendin-4
Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin‑4 mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin‑4 inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin‑4 reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin‑4 can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease.
GLP Receptor   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Type 2 Diabetes  
72
HY-B1618 Corticosterone
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Glucocorticoid Receptor   Endogenous Metabolite   iGluR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   SARS-CoV-2 Infection   Osteoarthritis  
71
HY-15084B Dizocilpine
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
iGluR  
Schizophrenia   Depression   Alzheimer's Disease   Parkinson's Disease  
52
HY-15084 Dizocilpine maleate
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
52
HY-114118A Semaglutide TFA
Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
GLP Receptor   Apoptosis   Bcl-2 Family   α-synuclein   Autophagy   Insulin Receptor   p38 MAPK  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
50
HY-114118 Semaglutide
Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
GLP Receptor   Apoptosis   Bcl-2 Family   α-synuclein   Autophagy   Insulin Receptor   p38 MAPK  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
50
HY-P0264 Exendin(9-39) amide
Exendin (9-39) amide (Avexitide) is a competitive GLP-1R antagonist. Exendin (9-39) amide blocks the Semaglutide (HY-114118)-induced increase in insulin secretion and also attenuates the hypoglycemic effect of Semaglutide. Exendin (9-39) amide abolishes the islet-protective effect of Liraglutide. Exendin (9-39) amide can be used in research on type 2 diabetes and type 1 diabetes.
GLP Receptor  
Type 1 Diabetes   Type 2 Diabetes  
46
HY-P0014 Liraglutide
Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.
GCGR   GLP Receptor  
Digestive System Disease   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease   Type 1 Diabetes   Psoriasis   Chronic Obstructive Pulmonary Disease   Type 2 Diabetes   Obesity  
43
HY-100714A D-AP5
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors.
iGluR  
Depression   Alzheimer's Disease   Parkinson's Disease  
37
HY-17551 NMDA
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
iGluR   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
33
HY-B1102 Evans Blue
Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability.
EAAT   iGluR  
Neurodegenerative Disease   Cardiovascular Disease  
33
HY-B0451 Dopamine
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
Dopamine Receptor   Endogenous Metabolite   Ferroptosis  
Neurological, Eye or Ear Disease  
32
HY-B0451A Dopamine hydrochloride
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
Dopamine Receptor   Endogenous Metabolite   Ferroptosis  
Neurological, Eye or Ear Disease  
32
HY-13749 Sitagliptin
Sitagliptin (MK-0431) is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes.
Dipeptidyl Peptidase   ERK   PKA   GLP Receptor  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Digestive System Inflammation   SARS-CoV-2 Infection   Obesity  
31
HY-P0252 α-MSH
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).
Melanocortin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
24
HY-Y0966 Glycine
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.
Ninjurin   Endogenous Metabolite   VEGFR   PROTAC Linkers   iGluR  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Schizophrenia   Pain   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Multiple Myeloma   HSV Infection   SARS-CoV-2 Infection   Alzheimer's Disease   Lung Fibrosis  
18
HY-N0637 Eriodictyol
Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases.
Melanocortin Receptor   TRP Channel  
Cancer   Inflammation or Immune System Disease   Viral Infection   Obesity   Lung Fibrosis  
16
HY-14608 L-Glutamic acid
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
Environmental Pollutants   Ferroptosis   iGluR   Endogenous Metabolite   Apoptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
16
HY-B0140 Aminophylline
Aminophylline is a competitive phosphodiesterase 3/4 (PDE3/4) inhibitor. Aminophylline also acts as an adenosine receptor antagonist. Aminophylline elevates intracellular cAMP levels via competitive inhibition of PDE3 and PDE4, antagonizes adenosine A1 receptor (ADORA1), regulates intracellular calcium signaling and synaptic vesicle cycling, upregulates the PPAR signaling pathway, and downregulates glutamatergic synaptic pathways simultaneously. Aminophylline can be used in research related to major depressive disorder, epilepsy, asthma, and chronic obstructive pulmonary disease (COPD).
Phosphodiesterase (PDE)   Adenosine Receptor   PPAR  
Depression   Epilepsy   Pulmonary Disease  
14
HY-100806 Kynurenic acid
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
iGluR   Endogenous Metabolite   Apoptosis   CXCR   GPR35  
Metabolic or Endocrine Disease   Colorectal Cancer   Depression   Digestive System Inflammation   Non-Small Cell Lung Cancer   Alzheimer's Disease   Parkinson's Disease  
11
HY-P0055 GLP-1(7-37)
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
GLP Receptor  
Metabolic or Endocrine Disease  
10
HY-N0215 L-Phenylalanine
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

Source: Escherichia coli

Calcium Channel   iGluR   Endogenous Metabolite  
Breast Cancer   Colorectal Cancer   Depression   Pain   SARS-CoV-2 Infection   Alzheimer's Disease   Hypertension   Phenylketonuria  
9
HY-19870C Setmelanotide monoacetate
Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.
Melanocortin Receptor   Calmodulin   AMPK  
Blood or Cardio-cerebrovascular Disease   Respiratory Disease   Obesity   Fatty Liver Disease  
8
HY-19870 Setmelanotide
Setmelanotide (RM-493) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide activates the CaMKK2/AMPK signaling pathway. Setmelanotide mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.
Melanocortin Receptor   Calmodulin   AMPK  
Blood or Cardio-cerebrovascular Disease   Respiratory Disease   Obesity   Fatty Liver Disease  
8
HY-76542 Vitamin D2
Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
Environmental Pollutants   VD/VDR   Endogenous Metabolite  
Type 1 Diabetes  
4
HY-Y0344H Sodium chloride, United States Pharmacopeia (USP) Reference Standard
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells.
Biochemical Assay Reagents   Na+/K+ ATPase   Interleukin Related  
Autoimmune Disease   Small Cell Lung Cancer  
3
HY-Y0344I Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt is an orally active salt. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the expression of ATP1A1. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt drives autoimmune disease by the induction of pathogenic Th17 cells.
Biochemical Assay Reagents   Na+/K+ ATPase   Interleukin Related  
Autoimmune Disease   Small Cell Lung Cancer  
3
HY-Y0344J Sodium chloride, for molecular biology
Sodium chloride is an orally active salt. Sodium chloride induces the expression of ATP1A1. Sodium chloride induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells.
Biochemical Assay Reagents   Na+/K+ ATPase   Interleukin Related  
Autoimmune Disease   Small Cell Lung Cancer  
3
HY-B1180 Vinburnine
Vinburnine ((-)-Eburnamonine; (-)-Vincamone) is an orally active, blood-brain barrier permeable immunomodulator and apoptosis inducer. Vinburnine drives the secretion of IL-24 by activating the P38/MAPK/ATF3 signaling axis. Vinburnine induces reactive oxygen species production and DNA damage in cancer cells, thereby inhibiting cancer cell proliferation, activating the apoptotic cascade, and enhancing CD8+ T cell function to remodel the tumor immune microenvironment. Vinburnine can be used in the research of diseases such as melanoma.
Apoptosis   p38 MAPK  
Melanoma  
3
HY-P3467 (Thr4,Gly7)-Oxytocin
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. .
Oxytocin Receptor   Potassium Channel  
Alzheimer's Disease  
3
HY-P0227 SHU 9119
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.
Melanocortin Receptor  
Metabolic or Endocrine Disease  
3
HY-Y0344D Sodium chloride, for cell culture
Sodium chloride, for cell culture is an orally active salt. Sodium chloride, for cell culture induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, for cell culture enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, for cell culture drives autoimmune disease by the induction of pathogenic Th17 cells.
Environmental Pollutants   Na+/K+ ATPase   Interleukin Related   Biochemical Assay Reagents  
Small Cell Lung Cancer   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
3
HY-P3506 Retatrutide
Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity.
GCGR   GLP Receptor  
Obesity  
3
HY-P1387 β-Amyloid (1-40) (rat)
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45Ca2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease.
Amyloid-β   Apoptosis  
Neurological, Eye or Ear Disease  
2
HY-D0227J THAM hydrochloride (≥99%, for cell culture)
THAM hydrochloride (≥99%, for cell culture) is a low-toxicity amino alcohol buffer, a specific CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM hydrochloride (≥99%, for cell culture) binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM hydrochloride (≥99%, for cell culture) may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM hydrochloride (≥99%, for cell culture) removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM hydrochloride (≥99%, for cell culture) can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM hydrochloride (≥99%, for cell culture) is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
2
HY-P2259 TAT-GluA2 3Y
TAT-GluA2 3Y is a blood-brain barrier-permeable AMPA receptor inhibitory peptide that crosses cell membranes via the HIV-1 TAT protein domain. TAT-GluA2 3Y blocks the endocytosis of AMPA receptors, including the internalization of GluA1/GluA2 subunits, by disrupting interactions with the AP2, Brag2 and Syt3-GluA2 complexes, while also inhibiting long-term depression. TAT-GluA2 3Y blocks hypoxia-mediated AMPAR internalization, alleviates A1R-induced persistent synaptic inhibition, and reduces cerebral ischemic volume, neurological deficits and spatial memory deficits. TAT-GluA2 3Y blocks the effect of NLRP3 deficiency on fear generalization, inhibits amphetamine-induced behavioral/neurochemical sensitization, weakens the unconditioned stimulus-conditioned stimulus association of morphine, and promotes the extinction of morphine CPP. TAT-GluA2 3Y can be used in studies related to fear generalization, ischemic stroke, hypoxia, drug addiction and opioid addiction.
iGluR   HIV Integrase   Adenosine Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
2
HY-P1335 CTAP
CTAP is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction.
Opioid Receptor  
Pain   Obesity  
2
HY-N0724 Mesaconitine
Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na+ and Ca2+ influx into endothelial cells, increases intracellular Na+ and Ca2+ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research.
NO Synthase  
Pain  
2
HY-P1335A CTAP TFA
CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction.
Opioid Receptor  
Neurological, Eye or Ear Disease  
2
HY-W010970 5'-Guanylic acid disodium salt
5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations.
Endogenous Metabolite   iGluR  
Metabolic or Endocrine Disease   Depression   Parkinson's Disease  
2
HY-P99019 Fremanezumab
Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC50 values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC50 value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine.

Species: Human

CGRP Receptor  
Inflammation or Immune System Disease   Pain  
2
HY-N5134 5'-Guanylic acid
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations.
Endogenous Metabolite   iGluR  
Metabolic or Endocrine Disease   Depression   Parkinson's Disease  
2
HY-D0914A Fast green FCF free acid
Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function.
α-synuclein  
Neurological, Eye or Ear Disease  
1
HY-P4106 Tat-GluR23Y, scrambled
Tat-GluR23Y, scrambled is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD).
Amino Acid Derivatives  
Neurological, Eye or Ear Disease  
1
HY-P1329 CTOP
CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity.
Opioid Receptor  
Neurological, Eye or Ear Disease  
1
HY-N2411 Geissoschizine methyl ether
Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice.
5-HT Receptor  
Neurological, Eye or Ear Disease  
1
HY-N3297 Meranzin hydrate
Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
mTOR   GHSR  
Depression  
1
HY-P1329A CTOP TFA
CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity.
Opioid Receptor  
Neurological, Eye or Ear Disease  
1
HY-18678 Bremelanotide
Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders.
Melanocortin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-W286743 Nε-(Carboxymethyl)-L-lysine
Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties.
Polo-like Kinase (PLK)   ERK   NF-κB  
Liver Cancer  
1
HY-B2176S5 ATP-15N5 dilithium
ATP-15N5 (Adenosine 5'-triphosphate-ATP-15N5) dilithium is the 15N5-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Isotope-Labeled Compounds   Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
1
HY-N2124 Parishin B
Parishin B is a multi-target biological agent with anti-epileptic, anti-fascioliasis and anti-breast cancer lung metastasis activities. Parishin B regulates the gene/protein activities of ACLY, unc13c, γ-aminobutynergic system, pro-inflammatory system, antioxidant system, monoaminergic system, ferroptosis-related pathways, as well as GST, CatL, Trx and TRIB3. Parishin B modulates energy-lipid metabolism, synaptic function, neurotransmitter balance, neuroinflammation, oxidative stress, parasite detoxification/invasion processes, as well as apoptosis, cell cycle, proliferation and metastasis of cancer cells. Parishin B can be used for related research of epilepsy, fascioliasis and breast cancer lung metastasis
Reactive Oxygen Species (ROS)   Ferroptosis   Apoptosis  
Lung Cancer   Breast Cancer   Parasitic Infection   Epilepsy   Antioxidant Agent  
1
HY-W250122 Glutamic acid sodium salt
Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders.
Biochemical Assay Reagents   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Apoptosis   HSP   Bcl-2 Family  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
1
HY-18678A Bremelanotide Acetate
Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders.
Melanocortin Receptor  
Metabolic or Endocrine Disease  
1
HY-D0914 Fast Green FCF
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function.
Environmental Pollutants   α-synuclein  
Neurological, Eye or Ear Disease  
1
HY-10624 THIQ
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants.
Melanocortin Receptor  
Obesity  
1
HY-P0267 Melanotan (MT)-II
Melanotan (MT)-II is a melanocortin receptor agonist. Melanotan (MT)-II activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.
Melanocortin Receptor  
Anxiety or Fear-Related Disease   Obesity   Erectile Dysfunction  
1
HY-N2466 Melanotan I
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction.
Melanocortin Receptor   Drug Derivative  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Urogenital Disease   Leukemia/Lymphoma/Myeloma  
1
HY-P80889 S100A10 Antibody (YA675)
S100A10 Antibody (YA675) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to S100A10.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

1
HY-B1470S Azaperone-d4
Azaperone-d4 (R-1929-d4) is the deuterium labeled Azaperone (HY-B1470). Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent.
Isotope-Labeled Compounds   Dopamine Receptor   Adrenergic Receptor  
Neurological, Eye or Ear Disease  
/
HY-100966S BD-1008-d5 dihydrobromide
BD-1008-d5 dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966). BD-1008 dihydrobromide is a nonselective σ receptor antagonist with Kis against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (Ki = 1112 nM) and dopamine transporter (DAT) (Ki > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor.
Isotope-Labeled Compounds   Sigma Receptor  
Neurological, Eye or Ear Disease  
/
HY-128733S Phenyl acetate-d5
Phenyl acetate-d5 is the deuterium labeled Phenyl acetate. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression.
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B1110S Nomifensine-d3 maleate
Nomifensine-d3 ((±)-Nomifensine-d3) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research.
Isotope-Labeled Compounds   Dopamine Receptor   Adrenergic Receptor  
Neurological, Eye or Ear Disease  
/
HY-118335S Prazobind-d8
Prazobind-d8 (SZL 49-d8) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure.
Isotope-Labeled Compounds   Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-B0457S1 Clomipramine-d6 hydrochloride
Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).
Isotope-Labeled Compounds   Serotonin Transporter  
Neurological, Eye or Ear Disease  
/
HY-N21686 Uralione I
Uralione I is a polycyclic polyprenylated acylphloroglucinol (PPAP) found in the whole plant of Hypericum uralum. Uralione I can be used for research on depression.
Endogenous Metabolite  
Depression  
/
HY-B0457S2 Clomipramine-13C,d3 hydrochloride
Clomipramine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).
Isotope-Labeled Compounds   Serotonin Transporter  
Neurological, Eye or Ear Disease  
/
HY-W009353S Tetrabutylammonium-d36 chloride
Tetrabutylammonium-d36 chloride (IPC-TBA-Cl-d36 chloride) is the deuterium labeled Tetrabutylammonium (chloride). Tetrabutylammonium chloride (IPC-TBA-Cl) is an organic compound commonly used as a catalyst and as an ionic liquid. It can be used to catalyze or promote reactions in certain organic reactions, and is widely used in batteries, solar cells and pigments. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
Isotope-Labeled Compounds  
/
HY-P11380 Capa-2
Capa-2 is a neuropeptide. Capa-2 activates calcium ion influx, stimulates the production of NO, activates soluble guanylate cyclase (sGC), increases intracellular cGMP, and drives ion and fluid secretion. Capa-2 can be used in studies of diuresis.
Neurotensin Receptor   Calcium Channel   NO Synthase   Guanylate Cyclase  
/
HY-150659S ATP-d14 disodium
ATP-d14 (Adenosine 5'-triphosphate-ATP-d14) sodium is the d14-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-W699792 R-(3)-Benzyloxymyristic acid methyl ester
R-(3)-Benzyloxymyristic acid methyl ester is a nonpolar solvent with activity for studying lipid-related interactions. R-(3)-Benzyloxymyristic acid methyl ester can be used in scientific research to explore the properties and behavior of cell membranes. R-(3)-Benzyloxymyristic acid methyl ester exhibits excellent solubility and compatibility in biochemical experiments.
Biochemical Assay Reagents  
/
HY-N15784 Tauro-12-oxolithocholanoic acid sodium
Tauro-12-oxolithocholanoic acid sodium is a bile acid (BA) suitable to investigate BAs and their relatives’ behavior and correlation with liver, gallbladder, and bile ducts diseases.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-N19954 Mustard extract
Mustard extract (Brassica junceal. extract) is extracted from mustard greens (Brassica juncea) and helps relieve stress and depression.
Others  
Neurological, Eye or Ear Disease  
/
HY-17571BS Oxytocin-d10 TFA
Oxytocin-d10 TFA (α-Hypophamine-d10 TFA) is the deuterium labeled Oxytocin TFA (HY-17571B). Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
Isotope-Labeled Compounds   Endogenous Metabolite   Oxytocin Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-P5179 Huwentoxin I
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively.
Calcium Channel   Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-P992436 PAS-003
PAS-003 is a humanized monoclonal antibody targerting α5β1 integrin. PAS-003 modulates immune cell migration, immune cell adhesion, improves behavior, and improves survival in ALS mouse models. PAS-003 can be used for the research of amyotrophic lateral sclerosis.

Species: Human

Integrin  
Amyotrophic Lateral Sclerosis  
/
HY-B0949AS Protriptyline-d3
Protriptyline-d3 is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease.
Cholinesterase (ChE)   Isotope-Labeled Compounds   Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-P7060 NT 13
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
iGluR  
Neurological, Eye or Ear Disease  
/
HY-D3225 MD-B
MD-B is a •OH Fluorescent probe with blood-brain barrier permeability. MD-B undergoes single-electron oxidation by hydroxyl radicals (•OH), which triggers fluorescence enhancement and enables in-situ imaging of •OH. MD-B allows imaging analysis of hydroxyl radicals (•OH) in the mouse brain, revealing a positive correlation between elevated •OH levels and the severity of depressive phenotypes. MD-B can be used in depression-related research.
Fluorescent Dye  
Depression  
/
HY-P992369 HMBD-002
HMBD-002 is an Fc-independent, non-depleting IgG4 subclass antibody that targets VISTA and VSIG3. It is widely used in research related to various solid tumors, including colon cancer, triple-negative breast cancer, and non-small cell lung cancer. HMBD-002 blocks the interactions of VISTA with VSIG3 and LRIG1, relieves immunosuppression without depleting VISTA-positive cells, activates the cytotoxic program of CD8+ T cells, and drives the type I interferon signaling pathway. HMBD-002 reprograms tumor-associated macrophages to the M1 phenotype, reduces tumor infiltration of inhibitory myeloid cells, thereby significantly inhibiting tumor growth and improving survival. HMBD-002 is well tolerated in rodent and non-human primate animal models.

Species: Human

VISTA  
Cancer  
/
HY-P3625 Dynorphin (2-17), amide (porcine)
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation.
Endogenous Metabolite   Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-P3984 Tyr-ACTH (4-9)
Tyr-ACTH (4-9) is a behaviorally active peptide. Tyr-ACTH (4-9) can be used for research of learned behavior extinction in the rat.
Others  
/
HY-P4708 Excitin 1
Excitin 1 is an orally active and CNS-penetrated peptide, alters behavior and brain monoamine and amino acid concentrations in rats.
Others  
Neurological, Eye or Ear Disease  
/
HY-P991510 CDX-1140
CDX-1140 is a fully human IgG monoclonal antibody and CD40 agonist, with a Kd value of 0.01 nM against human targets. The epitope of CDX-1140 locates at CD40 CRD1 and avoids the CD40L binding site. It activates DCs and B cells, drives NF-κB reporter gene activation, exhibits agonist activity independent of FcR cross-linking, and shows a synergistic effect with recombinant CD40L. CDX-1140 does not induce systemic cytokine release, exerts direct and immune-mediated anti-tumor activity in tumor xenografts, and has favorable safety profiles. When used as a local vaccine adjuvant in combination with 6MHP+mBRAF+poly-ICLC, CDX-1140 increases the number of DC-LAMP+ DCs and induces Th1 CD4+ responses in high-risk melanoma. CDX-1140 can be used in studies related to B-cell lymphoma, bladder cancer and high-risk melanoma.

Species: Human

TNF Receptor  
Bladder Cancer   Leukemia/Lymphoma/Myeloma   Melanoma  
/
HY-N12018 Isomaltopaeoniflorin
Isomaltopaeoniflorin is a metabolite of the Chinese herbal formula Shuyu. Shuyu is a depression-like disease inhibitor.
Others  
Neurological, Eye or Ear Disease  
/
HY-W089845S Heneicosane-d44
Heneicosane-d44 is the deuterium labeled Heneicosane (HY-W089845). Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs.
Isotope-Labeled Compounds   Fungal   Sex Pheromone  
Infection   Metabolic or Endocrine Disease  
/
HY-172754 ICAAc
ICAAc is a solvatochromic fluorophore with reduced basicity. ICAAc demonstrates significant solvatochromic behavior across solvents of varying polarity, with a large dipole moment difference and low quantum yield in water, making it a tunable solvatochromic fluorophore. ICAAc enables pH sensing via UV-vis/fluorescence detection and in microenvironments including sodium lauryl sulfate micelle Stern layers. ICAAc acts as a supravital cell stain for epifluorescence imaging of live cancer cells.
Fluorescent Dye  
Cancer  
/
HY-N0390G L-Glutamine (GMP)
L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
mTOR   NF-κB   STAT   HIF/HIF Prolyl-Hydroxylase  
Inflammation or Immune System Disease   Ischemic Stroke   Osteoporosis   Osteoarthritis  
/
HY-B0859S MCPA-13C8
MCPA-13C8 is the 13C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.
Isotope-Labeled Compounds   Herbicide   Cytochrome P450  
Metabolic or Endocrine Disease  
/
HY-N3297R Meranzin hydrate (Standard)
Meranzin hydrate (Standard) is the analytical standard of Meranzin hydrate (HY-N3297). This product is intended for research and analytical applications. Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
Reference Standards   mTOR   GHSR  
Depression  
/
HY-W748758 (Z)-Thiothixene-d8
(Z)-Thiothixene-d8 (NSC 108165-d8; Navan-d8; Navane-d8) is the deuterium labeled Thiothixene (HY-A0139). Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.
Isotope-Labeled Compounds   mAChR   Histamine Receptor   Sigma Receptor   Dopamine Receptor   Adrenergic Receptor  
/
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP)
1-Oleoyl lysophosphatidic acid sodium (GMP) is the GMP-grade form of 1-Oleoyl lysophosphatidic acid sodium (HY-107614). GMP-grade small molecules serve as auxiliary reagents in cell therapy. 1-Oleoyl lysophosphatidic acid sodium is a bioactive lipid signaling molecule. 1-Oleoyl lysophosphatidic acid sodium inhibits lysoPLD-catalyzed hydrolysis of lysophosphatidylcholine and FS-3. 1-Oleoyl lysophosphatidic acid sodium activates LPA1 and LPA2, thereby triggering calcium mobilization, NFATc1 translocation, Rho/ROCK activation, Smad2/3 phosphorylation and c-Fos expression. 1-Oleoyl lysophosphatidic acid sodium induces anxiety-like, depression-like and hypoactivity phenotypes, regulates osteoclast cytoskeleton and viability, reduces osteoclast bone resorptive activity, and drives mesenchymal stem cell differentiation into myofibroblast-like cells. 1-Oleoyl lysophosphatidic acid sodium stimulates the secretion of transforming growth factor-β1 and stromal cell-derived factor-1. 1-Oleoyl lysophosphatidic acid sodium is applicable to research related to anxiety, depression and ovarian cancer.
LPL Receptor   ROCK   TGF-beta/Smad   TGF-β Receptor  
Ovarian Cancer   Depression   Anxiety or Fear-Related Disease  
/
HY-139145S Etbicyphat-13C3
Etbicyphat-13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors.
GABA Receptor  
Neurological, Eye or Ear Disease  
/
HY-W040430R (S)-Nornicotine (Standard)
(S)-Nornicotine (Standard) is the analytical standard of (S)-Nornicotine (HY-W040430). This product is intended for research and analytical applications. (S)-Nornicotine is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine is useful for research on tobacco dependence and pain.
Reference Standards   Drug Metabolite   Cytochrome P450   nAChR  
Pain  
/
HY-B0356G Ciprofloxacin (GMP)
Ciprofloxacin GMP is Ciprofloxacin (HY-B0356) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Ciprofloxacin (Bay-09867) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity.
Bacterial   Topoisomerase   Akt   β-catenin  
Digestive System Disease   Periodontal Disease  
/
HY-P3679 Neuropeptide Y (1-24) (human)
Neuropeptide Y (1-24) (human) is a neuropeptide with potencies in inhibiting the electricity stimulated twitch response of rat vas deferens. Neuropeptide Y (1-24) (human) stimulates N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus in vivo.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-P10029 Sakura-6
Sakura-6 is a SERT-nnos interaction promoter that significantly increases the SERT-nnos complex, but reduces the level of SERT on the cell surface. Acute injection of Sakura-6 into the dorsal raphe nucleus (DRN) causes depression-like behavior in mice.
Serotonin Transporter  
Neurological, Eye or Ear Disease  
/
HY-P991380 TXB4
TXB4 is a brain-permeable human monoclonal antibody (mAb) targeting CD71. TXB4 prevents 6-OHDA-induced death of TH-positive neurons in the SNc in a 6-OHDA mouse model of Parkinson's disease (PD). TXB4 can be used in neurodegenerative diseases, acute brain and spinal cord injury, and depression research.

Species: Human

Transferrin Receptor  
Neurological, Eye or Ear Disease  
/
HY-P1134 Galanin (1-15) (porcine, rat)
Galanin (1-15) (porcine, rat) is the N-terminal 15 amino acids peptide fragment of the neuropeptide galanin. Galanin (1-15) (porcine, rat) interacts with the 5-HT1A receptor in the dorsal hippocampus of the rat brain, reduces the affinity of 5-HT1A receptors, and regulates the serotonin neuronal networks.
5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-B1052S1 Lofexidine-d4
Lofexidine-d4 (Baq-168 free base-d4) is deuterium labeled Lofexidine (HY-B1052A). Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal.
Isotope-Labeled Compounds   Adrenergic Receptor   Imidazoline Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-N20343 Blighted wheat extract
Blighted wheat extract (floating wheat extract) is a type of extract from floating wheat that can be used to study depression.
Others  
/
HY-P992209 Anti-CD318/CDCP1 Antibody (25A11)
Anti-CD318/CDCP1 Antibody (25A11) is an anti-CDCP1 antibody. Anti-CD318/CDCP1 Antibody (25A11) drives the internalization of antibody-CDCP1 complexes, inhibits cancer cell migration and invasion, and blocks downstream migration/invasion signaling pathways. When conjugated with saponin, Anti-CD318/CDCP1 Antibody (25A11) mediates the killing of prostate cancer cells. When conjugated with saponin, this antibody acts as an immunotoxin to inhibit the growth and metastasis of primary prostate tumors in mouse xenograft models. Anti-CD318/CDCP1 Antibody (25A11) is applicable to prostate cancer-related research.

Species: Human

Transmembrane Glycoprotein  
Prostate Cancer  
/
HY-P992174 ADI-14359
ADI-14359 is an antibody that binds to RSV postF, with a KD value of 387 nM, and exhibits non-neutralizing activity. ADI-14359 binds to antigenic site I on RSV postF through interactions of its conserved CDR H3 motif, germline-encoded IGKV1-39 light chain residues and heavy chain residues, where the light chain mediates preferential binding to postF by conflicting with the rearranged preF region. ADI-14359 can be used in studies related to respiratory syncytial virus (RSV) infection.

Species: Human

RSV  
Respiratory Syncytial Virus Infection  
/
HY-P3646 [DAla2] Dynorphin A (1-9) (porcine)
[DAla2] Dynorphin A (1-9) (porcine) is a dynorphin, which can be used in studies of analgesic, addiction, and depression.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-P10041 Obestatin(11-23)mouse, rat
Obestatin(11-23)mouse, rat is a polypeptide involved in regulating energy balance and inhibiting eating. Obestatin(11-23)mouse, rat causes reduced food intake, body weight, and jejunal contractions in rodents.
Others  
Metabolic or Endocrine Disease  
/
HY-P3445 Anrikefon
Anrikefon is a peripherally restricted kappa opioid receptor (KOR) agonist, with an IC50 of 0.54 nM, an EC50 of 2.41 pM, and a Ka of 0.068 nM against human KOR, and it exhibits high selectivity over μ and δ opioid receptors. Anrikefon exerts analgesic effects by inhibiting behaviors associated with inflammatory, postoperative and neuropathic pain, and also exerts antipruritic effects by reducing itch-related behaviors. Anrikefon can be used in research on pain, pruritus, and pruritus associated with chronic kidney disease.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-N20283 Catechu extract
Catechu extract is an extract of catechu (Areca catechu L.) that can be used in research on parasitic diseases and depression.
Parasite  
Neurological, Eye or Ear Disease  
/
HY-N3298R Meranzin (Standard)
Meranzin (Standard) is the analytical standard of Meranzin (HY-N3298). This product is intended for research and analytical applications. Meranzin is an orally active antidepressant and GHSR modulator. Meranzin significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
Reference Standards   mTOR   GHSR  
Depression  
/
HY-D3226 Zinc(II) probe-1
Zinc (II) probe-1 (Compound DNP) is a dual-color Fluorescent probe that can simultaneously monitor Zn2+ and H+. Upon interaction with Zn2+, Zinc (II) probe-1 produces bright blue fluorescence (excitation wavelength: 405 nm; blue channel wavelength: 420-500 nm). Upon interaction with H+, Zinc (II) probe-1 exhibits red fluorescence (excitation wavelength: 561 nm; red channel emission wavelength: 630-730 nm). Zinc (II) probe-1 can be used in studies related to depression.
Fluorescent Dye  
Depression  
/
HY-N20598 Bean sprout extract
Bean sprout extract is an extract from bean sprouts (sprouted broad beans) that can help relieve anxiety and depression.
Others  
Neurological, Eye or Ear Disease  
/
HY-N18061 Neoazedarachin B
Neoazedarachin B is an insect antifeedant present in the root bark of Melia toosendan. Neoazedarachin B reduces the feeding behavior of third-instar larvae of Spodoptera littoralis.
Insecticide  
Infection  
/
HY-D2970 Golgi-P
Golgi-P is a near-infrared Golgi-targeted fluorescent probe specifically used for the detection of Golgi polarity in living cells and living tissues. Golgi-P exhibits a significant polarity-dependent spectral behavior, with its emission wavelength shifting redward with polarity (Ex/Em: 700 nm/780-825 nm). Golgi-P achieves near-infrared fluorescence imaging directly in the brain tissue of depressed mice. Golgi-P combines polarity sensing with Golgi-targeting functionality, providing a new tool for the molecular diagnosis of depression.
Fluorescent Dye  
Depression  
/
HY-Y1754 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid
2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) is a compound with the ability to probe conformational changes, folding processes and interactions of peptides and proteins. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid is often used in relevant biological research to gain a deeper understanding of the behavior and function of biomacromolecules. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid plays an important role in analyzing the interactions and dynamic responses of biological systems.
Biochemical Assay Reagents  
/
HY-P5334 AADvac 1
AADvac 1 is an active tau peptide vaccine for Alzheimer's disease research. AADvac 1 is composed of a regulatory peptide 294KDNIKHVPGGGS305 that drives tau oligomerization conjugated to Aplysia hemocyanin (KLH) and formulated with aluminum hydroxide.
Others  
Neurological, Eye or Ear Disease  
/
HY-D3420 Neuro-DiI
Neuro-DiI is a red retrograde Fluorescent tracer. Neuro-DiI is transported retrogradely to the cell bodies in the ventral tegmental area and labels ventral tegmental area neurons with red fluorescence.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-P992388 IO-108
IO-108 is a humanized IgG4 monoclonal antibody and a competitive inhibitor of LILRB2, with a KD value of 1.97 nM. IO-108 competitively blocks the binding of LILRB2 to its ligands including HLA-G, MHC-I, ANGPTL2 and SEMA4A, reprograms tumor-associated myeloid cells, drives the conversion of suppressive myeloid cells into a pro-inflammatory phenotype, and restores the cytotoxic activity of T cells and NK cells. IO-108 inhibits tumor growth in LILRB2 transgenic mouse models. IO-108 can be used for the research of solid tumors.

Species: Human

LILRB  
Cancer  
/
HY-W040430A (S)-Nornicotine hydrochloride
(S)-Nornicotine hydrochloride is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine hydrochloride weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine hydrochloride promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine hydrochloride reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine hydrochloride is useful for research on tobacco dependence and pain.
Drug Metabolite   Cytochrome P450   nAChR  
Pain  
/
HY-D1426 Di-12-ANEPPQ
Di-12-ANEPPQ is a fast-responding membrane potential dye. Di-12-ANEPPQ, the lipophilic dye, shows cell-specific loading and Golgi-like staining patterns with minimal background fluorescence in the slices of neocortex and hippocampus.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-P2135 Neuropeptide AF1
Neuropeptide AF1 is a FMRFamide-like neuropeptide. Neuropeptide AF1 can be isolated from head extracts of the nematode Ascaris suum. Neuropeptide AF1 rapidly and reversibly abolishs slow membrane potential oscillations of identified ventral and dorsal inhibitory motoneurons and selectively reduces their input resistances. Neuropeptide AF1 inhibits locomotory movements in intact Ascaris.
Others  
Neurological, Eye or Ear Disease  
/
HY-W002112S1 (±)-Nornicotine-d7
(±)-Nornicotine-d7 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
Isotope-Labeled Compounds   Endogenous Metabolite   Drug Metabolite   nAChR   β-catenin  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W778608R Quercetin 7-glucuronide (Standard)
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
Drug Metabolite   Reference Standards  
Inflammation or Immune System Disease  
/
HY-W704752 Z-Doxepin-d3 Hydrochloride
Z-Doxepin-d3 hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride (HY-W704749). 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis.
Isotope-Labeled Compounds   Drug Metabolite   Dopamine Receptor  
Neurological, Eye or Ear Disease  
/
HY-D3152 NRh-Cu
NRh-Cu is a highly sensitive near-infrared fluorescence turn-on indicator and Cu2+-selective probe (λex=680 nm, λem=740 nm). When NRh-Cu interacts with Cu2+, it undergoes a structural transition from a non-fluorescent spirocyclic state to a fluorescent ring-opened state, which drives the enhancement of fluorescence emission. NRh-Cu can be used for Cu2+ imaging in live cells and in vivo.
Fluorescent Dye  
/
HY-133985 7(Z)-Pentacosene
7(Z)-Pentacosene is an aggregation pheromone of the European earwig (Forficula auricularia). 7(Z)-Pentacosene can be used in the study of insect behavior and neurobiology.

Source: Forficula auricularia

Sex Pheromone  
Neurological, Eye or Ear Disease  
/
HY-W591332A mPEG1000-DMPE
mPEG1000-DMPE is a PEGylated 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (14:0 PE) compound with a methyl group at the?other?end of the PEG chain. The PEG polymer exhibits amphiphatic behavior and helps to form stable micelles in an aqueous solution. It can be used to prepare nanoparticles or liposomes for targeted drug delivery applications.
Biochemical Assay Reagents  
/
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, an oxytocin receptor antagonist, abolishes oxytocin-enhanced inhibitory postsynaptic currents in CA1 pyramidal neurons.
Oxytocin Receptor  
Metabolic or Endocrine Disease  
/
HY-P5154 Tamapin
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus).
Potassium Channel  
Neurological, Eye or Ear Disease  
/
HY-P5043 α-Synuclein (67-78) (human)
α-Synuclein (67-78) (human) is the 67-78 fragment of α-Synuclein. α-Synuclein (67-78) (human) promotes network activity drive and blocks KCl-induced syt1L-ab uptake.
α-synuclein  
Neurological, Eye or Ear Disease  
/
HY-W738587 Threo-dihydrobupropion-d9 hydrochloride
rac-threo-Dihydro Bupropion Hydrochloride-d9 is the deuterium labeled Threo-dihydrobupropion hydrochloride (HY-131479). Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry.
Isotope-Labeled Compounds   Drug Metabolite  
Neurological, Eye or Ear Disease  
/
HY-17447SA Tranylcypromine-d5 hydrochloride
Tranylcypromine-d5 (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis.
Monoamine Oxidase   Histone Demethylase  
Neurological, Eye or Ear Disease  
/
HY-B1115S1 Buspirone-d8 (di(hydrochloride))
Buspirone-d8 dihydrochloride is the deuterium labeled Buspirone hydrochloride (HY-B1115). Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research.
Isotope-Labeled Compounds   5-HT Receptor   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P11222 Tat-SERT-15C
Tat-SERT-15C is a peptide. Tat-SERT-15C decreases the SERT-nNOS complex and increases SERT. Tat-SERT-15C reverses chronic unpredictable mild stress-caused depression behaviors.
Serotonin Transporter   NO Synthase  
Neurological, Eye or Ear Disease  
/
HY-W720758 3,7,11-Trimethyl-1-dodecanol
3,7,11-Trimethyl-1-dodecanol is an alcohol volatile organic compound present in Spirulina platensis, with a faint odor. 3,7,11-Trimethyl-1-dodecanol inhibits the oviposition behavior of female Ostrinia nubilalis (European corn borer). 3,7,11-Trimethyl-1-dodecanol can be used in studies related to behavioral regulation of agricultural pests.
Insecticide  
Plant Infection  
/
HY-131587 Integerrimine N-oxide
Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring.
Others  
/
HY-N4097R Incensole (Standard)
Incensole (Standard) is the analytical standard of Incensole. This product is intended for research and analytical applications. Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression.
Reference Standards   Others  
Neurological, Eye or Ear Disease  
/
HY-N13195 (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one
(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one shows a 5a-reductase inhibitory activity with an IC50 value of 41.9 μM. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one inhibits the growth of the ventral prostate induced by testosterone in rat. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is promising for research of benign prostatic hyperplasia (BPH) as well as other 5α-dihydrotestosterone (DHT)-related disorders, such as acne and male pattern baldness.

Source: Ganoderma lucidum

5 alpha Reductase  
/
HY-W243653 11-Dodecenyl acetate
11-Dodecenyl acetate is a insect sex pheromone, which is involved in attraction behavior of male moths.

Source: Plusia chalcites

Endogenous Metabolite  
/
HY-W007828R Methyl 3-phenylpropanoate (Standard)
Methyl 3-phenylpropanoate (Standard) is the analytical standard of Methyl 3-phenylpropanoate (HY-W007828). This product is intended for research and analytical applications. Methyl 3-phenylpropanoate is a phenylpropionate compound. Methyl 3-phenylpropanoate derivatives interfere with insect feeding behavior. Methyl 3-phenylpropanoate can be used to study insect feeding behavior.
Reference Standards   Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-15401A WAY 163909 (hydrochloride)
WAY 163909 hydrochloride is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 hydrochloride exhibits an EC50 of 8 nM and a Ki of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 hydrochloride induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 hydrochloride alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 hydrochloride can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia.
5-HT Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-W713900 MCPA-d3-1
MCPA-d3-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.
Isotope-Labeled Compounds   Cytochrome P450   Herbicide  
Metabolic or Endocrine Disease  
/
HY-P10405 TAT-D1 peptide
TAT-D1 peptide is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide can be used in the research of psychostimulant addiction, depression and anxiety disorders.
Dopamine Receptor  
Neurological, Eye or Ear Disease  
/
HY-W067716R Spinacine (Standard)
Spinacine (Standard) is the analytical standard of Spinacine (HY-W067716). This product is intended for research and analytical applications. Spinacine ((S)-Spinacine) is a GABA uptake inhibitor. Spinacine enhances synaptic GABA effects via inhibition of gamma-aminobutyric acid uptake in cerebral cortex slices. Spinacine inhibits reflex responses of ventral roots in isolated spinal cord. Spinacine inhibits motor activity and reduces approaches to water dispensers in conflict situations. Spinacine raises pain sensitivity threshold via subarachnoidal injection.
Reference Standards   GABA Receptor  
Neurological, Eye or Ear Disease  
/
HY-B2176BR ATP dimagnesium (Standard)
ATP (dimagnesium) (Standard) is the analytical standard of ATP (dimagnesium). This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation.
Endogenous Metabolite   Reference Standards  
Inflammation or Immune System Disease  
/
HY-B0949S Protriptyline (N-methyl-d3) hydrochloride
Protriptyline (N-methyl-d3) (hydrochloride) is the deuterium labeled Protriptyline hydrochloride. Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.
Isotope-Labeled Compounds   Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-B1052S Lofexidine-d4 hydrochloride
Lofexidine-d4 hydrochloride (Baq-168-d4) is the deuterium labeled Lofexidine hydrochloride (HY-B1052). Lofexidine hydrochloride (Baq-168) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine hydrochloride binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine hydrochloride regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine hydrochloride is applicable to research on opioid addiction and withdrawal.
Isotope-Labeled Compounds   Adrenergic Receptor   Imidazoline Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P1474 β-Amyloid (22-35)
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).
Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-P1025 M40
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P5154A Tamapin TFA
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus).
Potassium Channel  
Neurological, Eye or Ear Disease  
/
HY-P5334A AADvac 1 TFA
AADvac 1 TFA is an active tau peptide vaccine for Alzheimer's disease research. AADvac 1 TFA is composed of a regulatory peptide 294KDNIKHVPGGGS305 that drives tau oligomerization conjugated to Aplysia hemocyanin (KLH) and formulated with aluminum hydroxide.
Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-P2046 β-Endorphin (rat)
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction.
Opioid Receptor  
Neurological, Eye or Ear Disease  
/
HY-106784A (E)-Ajoene
(E)-Ajoene is an organosulfur compound and a neuroprotective agent with oral activity. (E)-Ajoene attenuates ischemia/reperfusion-induced hyperactivity, neuronal death in the hippocampal CA1 region, reactive astrogliosis, and reactive microgliosis. (E)-Ajoene is the E isomer of Ajoene (HY-106784) found in oil-macerated garlic products. (E)-Ajoene can be used for research on transient forebrain ischemia.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-129146S Doxapram-d5 hydrochloride
Doxapram-d5 hydrochloride is deuterium labeled Doxapram hydrochloride. Doxapram hydrochloride is a respiratory stimulant. Doxapram hydrochloride increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram hydrochloride inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively. Doxapram hydrochloride inhibits the Ca²⁺-activated potassium current (IC50 ≈ 13 μM) and Ca²⁺-independent potassium current (IC50 ≈ 20 μM) in type I cells of the carotid body. Doxapram hydrochloride significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram hydrochloride can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity.
Isotope-Labeled Compounds   Potassium Channel  
/
HY-P3819 Delta (Phospho) Sleep Inducing Peptide
Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats.
Others  
Neurological, Eye or Ear Disease  
/
HY-W020795 Hexadecyl β-D-maltoside
Hexadecyl β-D-maltoside is the anomer of Hexadecyl α-d-maltoside. Hexadecyl β-D-maltoside is different from Hexadecyl α-d-maltoside, showing non-Newtonian behavior, including thixotropic behavior, shear-thinning, and viscoelastic behavior.
Biochemical Assay Reagents  
/
HY-P991149 Nesfrotamig
Nesfrotamig (YH32367; ABL105) is a bispecific activator targeting HER2 and 4-1BB. The Kd values of Nesfrotamig for human HER2 and human 4-1BB are 0.48 nM and 3.36 nM, respectively. By blocking tumor cell growth signals, activating HER2-dependent local 4-1BB in tumors to maintain T cell survival, and inducing NK cell-mediated antibody-dependent cellular cytotoxicity, Nesfrotamig enhances the cytotoxicity and tumor infiltration ability of immune cells. Nesfrotamig promotes the generation of tumor-specific memory T cells, drives T cell-mediated tumor lysis, exhibits significant anti-tumor efficacy against both HER2-positive and HER2-low-expressing tumors, and shows synergistic activity when combined with anti-PD-1 antibodies. In cynomolgus monkey studies, Nesfrotamig demonstrates good safety and is suitable for research related to HER2-positive and HER2-low-expressing tumors.

Species: Human

TNF Receptor  
Breast Cancer   HER2-Positive Gastric Cancer  
/
HY-N3298 Meranzin
Meranzin is an orally active antidepressant and GHSR modulator. Meranzin significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
mTOR   GHSR  
Depression  
/
HY-P10405A TAT-D1 peptide acetate
TAT-D1 peptide acetate is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide acetate disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide acetate produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide acetate can be used in the research of psychostimulant addiction, depression and anxiety disorders.
Dopamine Receptor  
Depression   Anxiety or Fear-Related Disease  
/
HY-P4118 EB1 peptide
EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research.
Amino Acid Derivatives   Peptide-Drug Conjugates (PDCs)  
/
HY-N0927 (-)-Isocorypalmine
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research.
Dopamine Receptor  
Behavioral Addiction  
/
HY-N3182 N-Methylnuciferine
N-Methylnuciferine, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior.
Others  
Neurological, Eye or Ear Disease  
/
HY-150843S ATP-15N5 ammonium
ATP-15N5 (Adenosine 5'-triphosphate-ATP-15N5) ammonium is the 15N5-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-B0345AS ATP-18O4 sodium
ATP-18O4 (disodium salt) is the 18O labeled ATP disodium salt. ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-76542S Vitamin D2-d6
Vitamin D2-d6 is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
Isotope-Labeled Compounds   VD/VDR   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-171746 F4-Trp
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR). F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases.
nAChR  
Neurological, Eye or Ear Disease  
/
HY-B1417S Nortriptyline-d3 hydrochloride
Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression.
Isotope-Labeled Compounds   Autophagy   Apoptosis   Drug Metabolite  
Cancer   Neurological, Eye or Ear Disease  
/
HY-B1198S Piperonyl butoxide-d9
Piperonyl butoxide-d9 is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice.
Isotope-Labeled Compounds   Parasite  
Cancer   Infection  
/
HY-P991611 ART5803
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis.

Species: Human

iGluR  
Inflammation or Immune System Disease  
/
HY-P991525 2141-V11
2141-V11 is an Fc-engineered agonistic antibody against human CD40 with selectively enhanced binding affinity for human FcγRIIB. 2141-V11 drives CD40 multimerization and agonistic signal transduction, activates dendritic cells, promotes antigen cross-presentation and CD8+ T cell priming, induces tertiary lymphoid structure formation, increases leukocyte infiltration, and mediates local and abscopal anti-tumor effects, systemic immune activation and immune memory. 2141-V11 exhibits extremely low systemic toxicity upon intratumoral or intravesical administration, with no dose-limiting toxicity observed at the tested intratumoral doses, whereas high-dose systemic administration induces thrombocytopenia and elevated transaminases. 2141-V11 can be used in research related to breast cancer, melanoma, BCG-unresponsive non-muscle invasive bladder cancer, and recurrent malignant glioma.

Species: Human

Fc Receptor (FcR)  
Breast Cancer   Bladder Cancer   Melanoma   Glioma  
/
HY-N5130 Effusol
Effusol, a phenolic constituent from Juncus effuses, exhibits potent scavenging activity for DPPH and ABTS radicals, with IC50 values of 79 μM and 2.73 μM, respectively. Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampal function against stress-induced cognitive decline.
Free Radical Scavengers  
Neurological, Eye or Ear Disease  
/
HY-N4097 Incensole
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression.
Others  
Neurological, Eye or Ear Disease  
/
HY-P991752 Anti-Mouse CXCL16 Antibody (12-81)
Anti-Mouse CXCL16 Antibody (12-81) is an antibody targeting mouse CXCL16. Anti-Mouse CXCL16 Antibody (12-81) blocks the CXCL16/CXCR6 signaling axis. Anti-Mouse CXCL16 Antibody (12-81) reduces the recruitment of CD8+ T cells into the brain. Anti-Mouse CXCL16 Antibody (12-81) alleviates the reduction of hippocampal neurogenesis. Anti-Mouse CXCL16 Antibody (12-81) attenuates anxiety-like behaviors in mice. Anti-Mouse CXCL16 Antibody (12-81) can be used in studies related to anxiety-like behaviors. The recommended isotype control is Rat IgG1 kappa, Isotype Control (HY-P99979).

Species: Mouse

CXCR  
Anxiety or Fear-Related Disease  
/
HY-Y0284S Diethyl phthalate-d4
Diethyl phthalate-d4 is the d4 labeled Diethyl phthalate (HY-Y0284). Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility.
Isotope-Labeled Compounds   Apoptosis   Biochemical Assay Reagents   Phosphatase   Environmental Pollutants   Aminotransferases (Transaminases)  
Inflammation or Immune System Disease   Male Reproductive System Disease  
/
HY-P1474A β-Amyloid (22-35) TFA
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).
Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-30004R 1-Aminocyclopropane-1-carboxylic acid (Standard)
1-Aminocyclopropane-1-carboxylic acid (Standard) is the analytical standard of 1-Aminocyclopropane-1-carboxylic acid. This product is intended for research and analytical applications. 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity..
Reference Standards   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-B0859S1 MCPA-d3
MCPA-d3 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.
Isotope-Labeled Compounds   Herbicide   Cytochrome P450  
Metabolic or Endocrine Disease  
/
HY-D0844F Biotin-glutathione oxidized TFA
Biotin-glutathione oxidized TFA ((N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA) is an inducer of protein S-glutathionylation and a detection probe for S-glutathionylated proteins. Biotin-glutathione oxidized TFA forms protein-glutathione disulfide adducts, mimics components of oxidative stress, and drives protein S-glutathionylation. Biotin-glutathione oxidized TFA enables the labeling, detection, localization and purification of proteins susceptible to S-glutathionylation.
Others  
/
HY-P991183 SAR-442257
SAR-442257 is a trispecific T-cell engager and monoclonal antibody that binds to CD38, CD3 and CD28. SAR-442257 can target and bind to CD3 and CD28 on T cells, as well as CD38 expressed on tumor cells. SAR-442257 mediates T-cell activation, enhances T-cell activity, induces T-cell degranulation, and drives cytotoxicity against multiple myeloma cells. SAR-442257 functions via CD38 expression, and its in vitro activity correlates with CD38 expression on the surface of multiple myeloma cells. SAR-442257 can be used in studies related to multiple myeloma and relapsed/refractory multiple myeloma.

Species: Human

CD28   CD38   CD3  
Multiple Myeloma  
/
HY-B2176S7 ATP-13C2 dilithium
ATP-13C2 (Adenosine 5'-triphosphate-ATP-13C2) dilithium is the 13C2-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Isotope-Labeled Compounds   Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-B2176S4 ATP-d14 dilithium
ATP-d14 (Adenosine 5'-triphosphate-ATP-d14) dilithium is the d14-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Isotope-Labeled Compounds   Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-121650A ADTN hydrobromide
ADTN hydrobromide is a long-acting dopamine agonist. ADTN hydrobromide significantly decreases the behavioral visual threshold of DA-IPC-depleted zebrafish.
Dopamine Receptor  
Neurological, Eye or Ear Disease  
/
HY-W007828 Methyl 3-phenylpropanoate
Methyl 3-phenylpropanoate is a phenylpropanoate compound. Methyl 3-phenylpropanoate serves as a volatile oil component, a flavoring agent, and also an endogenous metabolite. Derivatives of Methyl 3-phenylpropanoate interfere with the feeding behavior of insects. Methyl 3-phenylpropanoate can be used to study insect feeding behavior.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-D0948 Celestine Blue
Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen.
Fluorescent Dye  
Infection  
/
HY-P11056 REF1 peptide
REF1 peptide is a PORK1 agonist with an EC50 of 0.028 nM in tomato. REF1 peptide binds to the extracellular domain of PORK1, triggers receptor autophosphorylation, and drives downstream MPK3/MPK6 activation, thereby initiating defense and regeneration signaling cascades. REF1 peptide induces callus formation, inhibits shoot regeneration upon continuous exposure, and enhances the regeneration and transformation efficiency of recalcitrant dicotyledonous and monocotyledonous crops.
MDM-2/p53  
/
HY-W040430 (S)-Nornicotine
(S)-Nornicotine is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine is useful for research on tobacco dependence and pain.
Drug Metabolite   Cytochrome P450   nAChR  
Pain  
/
HY-P1525 Melanin Concentrating Hormone, salmon
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.
MCHR1 (GPR24)  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N7117 1,4-Cineole
1,4-Cineole is an oxygenated monoterpene found in eucalyptus oil. 1,4-Cineole is a hTRPM8 and hTRPA1 agonist. 1,4-Cineole can increase intracellular Ca2+ concentration. 1,4-Cineole exhibits anti-anxiety and anti-depression effects. 1,4-Cineole can be used for the research of neurological disease, such as depression .
Environmental Pollutants   TRP Channel  
Pain  
/
HY-P991266 SM-17
SM-17 is a human monoclonal antibody targeting IL-17RB. SM-17 binds to human IL-17RB, inhibits the dimerization of IL-17RA/IL-17RB, blocks IL-25-induced phosphorylation of ERK1/2 and STAT5, and suppresses Th2-mediated inflammatory responses. SM-17 inhibits the secretion of IL-5, IL-9, IL-13 and IL-4, impairs the proliferation/expansion of ILC2 and Th2 cells, and restores filaggrin expression. SM-17 reduces immune cell infiltration, epidermal hyperplasia, goblet cell hyperplasia, collagen deposition, ear swelling and scratching behavior in animal models. SM-17 can be used in research related to atopic dermatitis and allergic asthma.

Species: Human

Interleukin Related   ERK   STAT  
Allergic Asthma   Atopic Dermatitis  
/
HY-N0801 Polygalacic acid
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.
MMP   Cholinesterase (ChE)  
Inflammation or Immune System Disease   Pancreatic Cancer   Pain   Lung Fibrosis  
/
HY-135794S 11-Ketodihydrotestosterone-d3
11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells.
Isotope-Labeled Compounds   Androgen Receptor  
Metabolic or Endocrine Disease  
/
HY-15330 Vitamin D2-d3
Vitamin D2-d3 (Ergocalciferol-d3) is the deuterium labeled vitamin D2 (HY-76542), where the C-6 and C-19 protons are replaced by deuterium. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
Isotope-Labeled Compounds   VD/VDR   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W009235 Tetraethylammonium p-toluenesulfonate
Tetraethylammonium p-toluenesulfonate p-toluenesulfonate is an organic compound commonly used as a catalyst and surfactant. It can be used to catalyze or promote reactions in certain organic synthesis reactions, and is widely used in the fields of surfactants, lubricants and antistatic agents. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
Biochemical Assay Reagents  
/
HY-N6960 L-Stepholidine
L-Stepholidine (Stepholidine) is an alkaloid. L-Stepholidine exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect. L-Stepholidine can be used for the researches of neurological disease, such as Parkinson disease, Alzheimer's disease and opiate addiction.
Dopamine Receptor  
Neurological, Eye or Ear Disease  
/
HY-P1437 Neuropeptide S (mouse)
Neuropeptide S (mouse) is a bioactive peptide. Neuropeptide S (mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-P1025A M40 TFA
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P10031 SAR441255
SAR441255 is a GLP-1R/GCGR/GIPR agonist, with human EC50 values of 1.03 pM, 1.01 pM, and 0.73 pM, respectively. SAR441255 stimulates receptor activity and drives cAMP accumulation. SAR441255 can be used for the research of type 2 diabetes, obesity.
GLP Receptor   GCGR  
Type 2 Diabetes   Obesity  
/
HY-W019901B Anhydrous calcium sulfate (97%)
Anhydrous calcium sulfate (97%) serves as an oil-based drilling fluid additive and an osteogenic material. Anhydrous calcium sulfate (97%) increases the plastic viscosity, yield point, apparent viscosity and gel strength of oil-based drilling fluids. Anhydrous calcium sulfate (97%) upregulates the expression of bone-related genes FOSL1, RUNX2 and SPP1. Anhydrous calcium sulfate (97%) significantly affects the behavior of dental pulp stem cells, enhancing their proliferation, differentiation and matrix deposition.
Environmental Pollutants   RUNX   Biochemical Assay Reagents  
Osteogenic Differentiation  
/
HY-N11908 α-Santalol
α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus.
Akt   Survivin   Apoptosis   Caspase   PARP  
Prostate Cancer   Glucose Metabolism  
/
HY-P10031A SAR441255 TFA
SAR441255 TFA is a GLP-1R/GCGR/GIPR agonist, with human EC50 values of 1.03 pM, 1.01 pM, and 0.73 pM, respectively. SAR441255 TFA stimulates receptor activity and drives cAMP accumulation. SAR441255 TFA can be used for the research of type 2 diabetes, obesity.
GLP Receptor   GCGR  
Type 2 Diabetes   Obesity  
/
HY-P1765 Galanin (1-19), human
Galanin (1-19), human is the 1-19 fragment of the human galanin. Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Obesity  
/
HY-121793 Roemerine
Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases.
Endogenous Metabolite   5-HT Receptor   mGluR   iGluR   Bacterial   Antibiotic  
Cancer   Bacterial Infection   Depression   Alzheimer's Disease  
/
HY-W002112S (±)-Nornicotine-d4
(±)-Nornicotine-d4 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
nAChR   Isotope-Labeled Compounds   Endogenous Metabolite   Drug Metabolite   β-catenin  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P1525A Melanin Concentrating Hormone, salmon TFA
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.
MCHR1 (GPR24)  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-75813 2-Aminonicotinaldehyde
2-Aminonicotinaldehyde is a synthetic intermediate. 2-Aminonicotinaldehyde can be used for the synthesis of 5-HT3 receptor antagonists, AKT inhibitors, and other compounds. 2-Aminonicotinaldehyde is applicable to research on depression and cancers (including hepatocellular carcinoma).
Biochemical Assay Reagents   Akt   5-HT Receptor  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P3581 PE 22-28
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.
Potassium Channel  
Neurological, Eye or Ear Disease  
/
HY-P1186 Eledoisin Related Peptide
Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.
Neurokinin Receptor  
Neurological, Eye or Ear Disease  
/
HY-W067716 Spinacine
Spinacine ((S)-Spinacine) is a GABA uptake inhibitor. Spinacine enhances synaptic GABA effects via inhibition of gamma-aminobutyric acid uptake in cerebral cortex slices. Spinacine inhibits reflex responses of ventral roots in isolated spinal cord. Spinacine inhibits motor activity and reduces approaches to water dispensers in conflict situations. Spinacine raises pain sensitivity threshold via subarachnoidal injection.
GABA Receptor  
Neurological, Eye or Ear Disease  
/
HY-141582 Ceramide 3
Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.
JNK   NF-κB   Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease  
/
HY-P3914 Cecropin A (1-7)-Melittin A (2-9)
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides.
Bacterial  
Infection  
/
HY-121447 Heneicosanoic acid
Heneicosanoic acid is an odd-chain saturated fatty acid widely present in human milk, fish, seeds, and cerebrosides in the cell membranes of the nervous system. Heneicosanoic acid can form Langmuir monolayers and is often used as a model to study lipid self-assembly and disassembly processes in biological membranes and drug delivery systems. In the low-temperature L'2 and CS crystalline phases, Heneicosanoic acid undergoes local oscillations, which in turn drive the spontaneous formation and expulsion of micelles and vesicles.
Endogenous Metabolite  
Lipid Metabolism  
/
HY-P1341 OXA(17-33)
OXA (17-33) (Orexin A (17-33) (human, mouse, rat, bovine)) is the shortest active orexin peptide that selectively targets OX1 (EC50=8.29 nM), with 23-fold selectivity for the OX1 receptor over the OX2 receptor. The activity of OXA (17-33) depends on the Tyr17, Leu20, Asn25, His26 residues and the spatial conformation of the α-helix. OXA (17-33) activates signaling pathways involving inositol-1,4,5-trisphosphate receptor (IP3R), phospholipase D (PL-D) and choline-Sigma-1R, thereby increasing the cytoplasmic Ca2+ level in nucleus accumbens neurons, an effect that is blocked by Sigma-1R antagonists. OXA (17-33) serves as an important biological probe for investigating the function of the OX1 receptor. OXA (17-33) can be modified via incorporation of mixed disulfide bonds of homocysteine and cysteamine, and is widely used in studies related to insomnia and narcolepsy.
Orexin Receptor (OX Receptor)   Sigma Receptor   Phospholipase  
Neurological, Eye or Ear Disease  
/
HY-W015780 1,4-Dimethoxybenzene
1,4-Dimethoxybenzene is an endogenous metabolite. 1,4-Dimethoxybenzene has an anti-anxiety effect, increasing atherogenic index (AI) levels in rabbits and inducing sedentary behavior. Sedentary behavior may increase blood cholesterol levels and disrupt blood lipids. 1,4-Dimethoxybenzene considers to be not clastogenic in the in vivo micronucleus test.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P990552A huATN-658
huATN-658 is an inhibitor that specifically targets the DIII domain of human urokinase plasminogen activator receptor (uPAR). huATN-658 neutralizes uPAR function by blocking the interaction between uPAR and integrins, without interfering with the binding of uPA or vitronectin to uPAR. huATN-658 inhibits the proliferation and invasion of breast cancer cells, slows the growth of primary breast tumors, reduces breast cancer-induced bone lesions and decreases osteoclast activity. huATN-658 also alters the gene expression of the TGF-β receptor complex signaling pathway. huATN-658 exerts synergistic anticancer effects when combined with Zoledronic Acid (HY-13777), and does not cause physiological or behavioral abnormalities in immunodeficient mice. huATN-658 can be used in research related to breast cancer, metastatic breast cancer and breast cancer-induced bone disease.

Species: Human

PAI-1   Integrin  
Metastatic Breast Cancer  
/
HY-150084 (±)14,15-Epoxyeicosatrienoic acid
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth.
Cytochrome P450   Mitosis  
Breast Cancer  
/
HY-P1212 Cortistatin 14 (mouse, rat)
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus.
Somatostatin Receptor  
Neurological, Eye or Ear Disease  
/
HY-P1192 GR-73632
GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus.
Neurokinin Receptor  
Neurological, Eye or Ear Disease  
/
HY-B0451AS7 Dopamine-d5 hydrochloride
Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
Isotope-Labeled Compounds   Dopamine Receptor   Endogenous Metabolite   Ferroptosis  
Neurological, Eye or Ear Disease  
/
HY-P99877 Efavaleukin alfa
Efavaleukin alfa (AMG592) is a IL-2 mutein fragment crystallizable fusion protein. Efavaleukin alfa drives the selective expansion of regulatory T cells. Efavaleukin alfa is applicable to research related to systemic lupus erythematosus.
Biochemical Assay Reagents  
Systemic Lupus Erythematosus  
/
HY-W127790 Bathophenanthrolinedisulfonic acid disodium
Bathophenanthrolinedisulfonic acid disodium is an iron ion chelator that serves as a colorimetric reagent for iron ion detection. Bathophenanthrolinedisulfonic acid disodium forms stable, strong complexes with Fe2+ and Fe3+, and each complex exhibits reversible redox behavior. Bathophenanthrolinedisulfonic acid disodium can act as a ligand to form water-soluble ruthenium catalysts, which promote the hydrogenation of the ketone group in levulinic acid to produce γ-valerolactone. When Bathophenanthrolinedisulfonic acid disodium and its iron complex are incorporated into a polymer-modified electrode, rapid color change from red to transparent occurs during potential cycling.
Biochemical Assay Reagents  
/
HY-W008145 Sodium tetrachloropalladate(II)
Sodium tetrachloropalladate(II) is an organic compound commonly used as a catalyst and as a raw material for dye production. It can be used to catalyze or promote reactions in certain chemical reactions, and is widely used in the fields of organic synthesis and dye preparation. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
Biochemical Assay Reagents  
/
HY-B0451AR Dopamine hydrochloride (Standard)
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
Reference Standards   Dopamine Receptor   Endogenous Metabolite   Ferroptosis  
Neurological, Eye or Ear Disease  
/
HY-B2176S6 ATP-13C10 dilithium
ATP-13C10 (Adenosine 5'-triphosphate-ATP-13C10) dilithium is the 13C10-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Isotope-Labeled Compounds   Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-Y1191 EEDQ
EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC50 = 78.3 μM). EEDQ inhibits contralateral rotation behavior.
Biochemical Assay Reagents   5-HT Receptor   Dopamine Transporter  
Neurological, Eye or Ear Disease  
/
HY-P1211 Adrenocorticotropic Hormone (ACTH) (1-39), human
Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist.
Melanocortin Receptor  
Infection   Metabolic or Endocrine Disease  
/
HY-P5971 TCMCB07
TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia. TCMCB07 has potential transport capabilities.
Melanocortin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-30004 1-Aminocyclopropane-1-carboxylic acid
1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity..
Endogenous Metabolite  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
/
HY-P4146 Survodutide
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
GLP Receptor   GCGR  
Digestive System Disease   Digestive System Inflammation   Type 2 Diabetes   Obesity  
/
HY-P990673 Vandortuzumab
Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC).

Species: Human

ADC Antibodies   Transmembrane Glycoprotein   Mitosis  
Castration-Resistant Prostate Cancer  
/
HY-P3375 Mazdutide
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D).
GCGR   GLP Receptor  
Metabolic or Endocrine Disease  
/
HY-P10408 Candidalysin
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity
EGFR   MMP   Calcium Channel   NOD-like Receptor (NLR)   ERK   p38 MAPK  
Infection   Inflammation or Immune System Disease  
/
HY-P7718 Carbonic Anhydrase 1 Protein, Human (His, solution)
Carbonic Anhydrase 1 Protein, Human (His, solution) expresses in E. coli with a His tag at the N-terminus. Carbonic Anhydrase 1 (CA1) expression and CA1-mediated calcification are significantly associated with atherosclerosis (AS) progression.

Species: Human; Source: E. coli

Enzymes & Regulators Lyases (EC 4) Carbonic Anhydrase Carbonic Anhydrase 1 (CA1)

/
HY-P7718A Carbonic Anhydrase 1 Protein, Human (His)
Carbonic Anhydrase 1 Protein, Human (His) is the recombinant human-derived Carbonic Anhydrase 1, expressed by E. coli , with C-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Lyases (EC 4)

/
HY-P700472 Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His)
Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

Species: Human; Source: HEK293

Receptor Proteins

/
HY-P72146 Claudin-3/CLDN3 Protein, Human (His-B2M)
Claudin-3/CLDN3 proteins play a critical role in tight junctions, eliminating intercellular spaces through calcium-independent cell adhesion activity. It exhibits multifunctionality by forming homo- and heteropolymers with other CLDN members, including CLDN1 and CLDN2. Claudin-3/CLDN3 Protein, Human (His-B2M) is the recombinant human-derived Claudin-3/CLDN3 protein, expressed by E. coli , with N-6*His, B2M labeled tag.

Species: Human; Source: E. coli

Receptor Proteins

/
HY-P704506 Claudin-3/CLDN3 Protein-VLP, Human (HEK293)
Claudin-3/CLDN3 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

Species: Human; Source: HEK293

Receptor Proteins

/
HY-P86091 Claudin 3 Antibody (YA5783)
Claudin 3 Antibody (YA5783) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P80889A S100A10 Antibody (YA675)(PBS only)
S100A10 Antibody (YA675) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to S100A10.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P82237 Carbonic Anhydrase 1 Antibody (YA1982)
Carbonic Anhydrase 1 Antibody (YA1982) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Carbonic Anhydrase 1.

Host: Rabbit; Reactivity: Human, Mouse, Rat, Zebrafish

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P85069 Carbonic Anhydrase 1 Antibody (YA4761)
Carbonic Anhydrase 1 Antibody (YA4761) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Carbonic Anhydrase 1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

/
HY-P85291 NAC-1 Antibody (YA4983)
NAC-1 Antibody (YA4983) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NAC-1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

/
HY-P85291A NAC-1 Antibody (YA4983)(PBS only)
NAC-1 Antibody (YA4983) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NAC-1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

/
HY-K6301 Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit

MCE Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit is a standardized culture system specifically designed to recapitulate the developmental processes and functional features of the human cerebral cortex through forebrain ventralization-based signaling regulation. By sequentially activating the Wnt/β-catenin pathway and gradually inhibiting BMP/Smad signaling, this system efficiently drives human pluripotent stem cells (PSC) to differentiate into high-purity glutamatergic neurons (VGLUT1/2+ > 85%), while simultaneously promoting the formation of Pax6+/BLBP+ radial glial cells that establish a biomimetic ventricular-zone–like structure.

Cell Biology 3D Cell Culture PSC Induction Product Series

/

References

[1]. Fanselow MS, et al. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010;65(1):7-19.  

[2]. Turner VS, et al. Linking external stimuli with internal drives: A role for the ventral hippocampus. Curr Opin Neurobiol. 2022;76:102590.  

[3]. Bakoyiannis I, et al. Pathway specific interventions reveal the multiple roles of ventral hippocampus projections in cognitive functions. Rev Neurosci. 2023;34(7):825-838.  

[4]. Kanoski SE, et al. Hippocampus contributions to food intake control: mnemonic, neuroanatomical, and endocrine mechanisms. Biol Psychiatry. 2017;81(9):748-756.  

[5]. Hsu TM, et al. A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling. Mol Psychiatry. 2018;23(7):1555-1565.  

[6]. Singh U, et al. Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation. Physiol Behav. 2023;262:114105.  

[7]. Patterson D, et al. Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict. PLoS Biol. 2025;23(1):e3002722.  [Content Brief]

[8]. Medrihan L, et al. Projections from ventral hippocampus to nucleus accumbens' cholinergic neurons are altered in depression. J Gen Physiol. 2025;157(3):e202413693.  [Content Brief]

[9]. Klug ME, et al. A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats. Neuropsychopharmacology. 2026;51(10):1779-1789.  [Content Brief]

[10]. Zhou Y, et al. The Projection From Ventral CA1, Not Prefrontal Cortex, to Nucleus Accumbens Core Mediates Recent Memory Retrieval of Cocaine-Conditioned Place Preference. Front Behav Neurosci. 2020;14:558074.  [Content Brief]

Keywords

ventral hippocampus | ventral CA1 | motivated behavior | internal state | external stimuli | motivational drive | nucleus accumbens | medial prefrontal cortex | approach-avoidance conflict | reward | food motivation | impulsivity | glutamatergic signaling | hippocampal-striatal circuit | hippocampal-prefrontal circuit | addiction | depression | energy balance