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19

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (970) Cardiovascular Disease (153) Endocrinology (57) Infection (545) Inflammation/Immunology (422) Metabolic Disease (289) Neurological Disease (376)
Click Chemistry:	DBCO (1) Azide (2) Alkynes (3)
Oligonucleotides:	miRNA mimics (9) Antigens (2) miRNA antagomirs (9) Chemokine & Receptors (1) Rat Pre-designed siRNA Sets (26) Liposome (2) miRNA inhibitors (9) mRNA (6) Phospholipids (3) siRNA drugs (1) Binders (1) siRNAs (122) miRNA agomirs (9) Pegylated Lipids (1) CAR-T (1) MicroRNAs (36) Nucleoside Analogs (1) CpG ODNs (2) Mouse Pre-designed siRNA Sets (26) Cationic Lipids (5) Human Pre-designed siRNA Sets (69) Interleukin & Receptors (1)

2591

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

105

Peptides

MCE Kits

Inhibitory Antibodies

280

Natural
Products

212

Recombinant Proteins

142

Isotope-Labeled Compounds

190

Antibodies

Click Chemistry

178

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138779

ICCB-19 hydrochloride 1 Publications Verification	Autophagy RIP kinase Apoptosis	Inflammation/Immunology
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins .

HY-B1710

Norethindrone acetate 19-Norethindrone acetate	Progesterone Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-169798

1,9-Dimethylmethylene blue	Fluorescent Dye VSV	Infection
1,9-Dimethylmethylene blue is a photosensitizer, virus inactivator and hemoglobin oxidant derived from methylene blue. When activated, 1,9-Dimethylmethylene blue generates reactive oxygen species including singlet oxygen, and acts as a metachromatic dye. When activated in monomeric or dimeric form, 1,9-Dimethylmethylene blue induces photoinactivation of R17 phage and vesicular stomatitis virus and oxidizes hemoglobin via non-singlet oxygen reactive oxygen species or singlet oxygen-mediated pathways, respectively. The monomeric form, with higher nucleic acid affinity, achieves virus inactivation under specific conditions without forming methemoglobin. 1,9-Dimethylmethylene blue binds to substances such as glycosaminoglycans to produce color changes. Although it is susceptible to interference from non-glycosaminoglycan components in urine, it is still applicable to spectrophotometric analysis for glycosaminoglycan quantification. With these unique photochemical and binding properties, 1,9-Dimethylmethylene blue is widely used in studies of viral infections and related biochemical analyses .

HY-N10379

19-epi-Scholaricine	Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related	Inflammation/Immunology
19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy .

HY-N8164

19α-Hydroxyasiatic acid	Elastase	Inflammation/Immunology
19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity .

HY-113302

19-Hydroxyandrost-4-ene-3,17-dione	Endogenous Metabolite	Others
19-Hydroxyandrost-4-ene-3,17-dione is a substrate for Corticotropin-lipotropin and Cytochrome P450 19A1.

HY-N8349

19,20-Epoxycytochalasin D	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-154830

Lysophosphatidylcholine C19:0 1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine; 19:0 Lyso PC	Liposome Interleukin Related	Others
Lysophosphatidylcholine C19:0 (1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine) is an acyl chain lipid. Lysophosphatidylcholine C19:0 increases IL-1beta secretion .

HY-W158327

Deca-1,9-diyne 1,9-Decadiyne	PROTAC Linkers	Cancer
Deca-1,9-diyne (1,9-Decadiyne) is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-P99218

Robatumumab Sch 717454; 19D12	IGF-1R	Cancer
Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research .

HY-N7019

19-Hydroxybufalin	Others	Cancer
19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .

HY-N0969

(Z)-Akuammidine 19-(Z)-Akuammidine; (Z)-Rhazine	Others	Others
(Z)-Akuammidine ((Z)-Rhazine) is isolated from Gelsemium elegans .

HY-W105726

1,9-Diaminononane	PROTAC Linkers	Cancer
1,9-Diaminononane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-118332

19(R)-HETE	Prostaglandin Receptor	Cardiovascular Disease
19(R)-HETE is a vasodilator in renal arteries, whereas 19(S)-HETE was relatively inactive .

HY-N16573

19-epi-Voacristine	Others	Cancer
19-epi-Voacristine is an indole alkaloid. 19-epi-Voacristine exhibits cytotoxic activity against the A2780 ovarian cancer cell line .

HY-113233

19-Noretiocholanolone	Androgen Receptor	Metabolic Disease
19-Noretiocholanolone is an anabolic androgenic steroid metabolite of Nandrolone .

HY-114649

19-Hydroxy cholesterol 1 Publications Verification	Drug Derivative	Metabolic Disease
19-Hydroxy cholesterol is an ester product.

HY-W127525

19-Methyleicosanoic acid	Biochemical Assay Reagents	Others
19-methyleicosanoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-32874

1,9-Dibromononane	PROTAC Linkers	Cancer
1,9-Dibromononane is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-115340S

Decanoic acid-d19 sodium Sodium decanoate-d19 sodium; Sodium caprate-d19 sodium	Isotope-Labeled Compounds	Others
Decanoic acid-d₁₉ (sodium) is the deuterium labeled Decanoic acid .

HY-105419

KP-19	Drug Derivative	Cardiovascular Disease
KP-19 is a Propranolol (HY-B0573B) analogue. KP-19 can be used for the research of cardiovascular disease .

HY-N7972

19-Oxocinobufotalin	Others	Cancer
19-Oxocinobufotalin is capable of suppressing EMT (Epithelial-mesenchymal transition) and weakening the migratory and invasive potential of PC3 cells .

HY-N10376

Lagunamine 19-Hydroxytubotaiwine	Others	Infection Cancer
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

HY-B1710R

Norethindrone acetate (Standard) 19-Norethindrone acetate (Standard)	Reference Standards Progesterone Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Norethindrone acetate (Standard) is the analytical standard of Norethindrone acetate. This product is intended for research and analytical applications. Norethindrone acetate is a female hormone used for the research of endometriosis . Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W480392

1,9-Dimethylxanthine	Adenosine Receptor
1,9-Dimethylxanthine is an adenosine receptor antagonist that has the activity of blocking the effects of adenosine on the central nervous system. 1,9-Dimethylxanthine enhances nerve excitability by regulating the adenosine system. 1,9-Dimethylxanthine is used as a pharmacological tool in research to help explore physiological and pathological processes related to adenosine.

HY-W460257

19-Methoxy-19-oxononadecanoic acid	PROTAC Linkers	Cancer
19-Methoxy-19-oxononadecanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-CE00583

19-Methylhenicosanoyl-CoA 19-Methylhenicosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
19-Methylhenicosanoyl-CoA (19-Methylhenicosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00605

19-Methylpentacosanoyl-CoA 19-Methylpentacosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
19-Methylpentacosanoyl-CoA (19-Methylpentacosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00574

19-Methyldocosanoyl-CoA 19-Methyldocosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
19-Methyldocosanoyl-CoA (19-Methyldocosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00610

19-Methyleicosanoyl-CoA 19-Methyleicosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
19-Methyleicosanoyl-CoA (19-Methyleicosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00609

19-Methyltricosanoyl-CoA 19-Methyltricosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
19-Methyltricosanoyl-CoA (19-Methyltricosanoyl-coenzyme A) is a coenzyme A derivative.

HY-133954

19-Heptatriacontanol 19-Hydroxyheptatriacontane	Biochemical Assay Reagents	Others
19-Heptatriacontanol is used to combine macromolecules and small molecules.

HY-N12253

(19R)-13-Deoxy-19-hydroxyenmein	Others	Cancer
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

HY-115957

Tubulin inhibitor 19	Microtubule/Tubulin	Cancer
Tubulin inhibitor 19 (compound 9b) is a potent inhibitor of tubulin. Tubulin inhibitor 19 is an indole chalcone compound. Tubulin inhibitor 19 has the potential for the research of cancer diseases .

HY-W748297

NK 19 diiodide	Fluorescent Dye	Others
NK 19 diiodide is a photosensitive cyanin dye. NK 19 diiodide is an immunomodulator capable of modifying immunological function of the impaired lymphocytes. NK 19 diiodide can be used for research of wounds and burns .

HY-143457

Anti-inflammatory agent 19	NO Synthase	Inflammation/Immunology
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC₅₀ of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .

HY-146916S

19:0-12:0-19:0 TG-d5	Isotope-Labeled Compounds	Others
19:0-12:0-19:0 TG-d₅ is deuterium labeled 19:0-12:0-19:0 TG.

HY-P5567

GLR-19	HIV HSV	Infection
GLR-19 is an anti-HIV peptide. GLR-19 also has antiviral activity against HSV-2 .

HY-173307

Nrf2 activator 19	Keap1-Nrf2 Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nrf2 activator 19 is a BBB-penetrable NRF2/HO-1 activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research .

HY-N10778

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol	Others	Others
(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .

HY-157124

Tyrosinase-IN-19	Tyrosinase	Metabolic Disease
Tyrosinase-IN-19 (compound 9) is a competitive tyrosinase inhibitor. Tyrosinase-IN-19 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals. Tyrosinase-IN-19 suppresses tyrosinase expression in a dose-dependent manner .

HY-142972

19(S)-HETE	Prostaglandin Receptor	Cardiovascular Disease
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC₅₀ value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels .

HY-N7017

19-Oxocinobufagin	Others	Metabolic Disease
19-Oxocinobufagin is a bufadienolide in toad venom .

HY-138970

(±)19(20)-EDP ethanolamide 19,20-DHEA epoxide; 19,20-Epoxy docosapentaenoic acid ethanolamide; 19,20-EDP-EA	Interleukin Related	Others
(±)19(20)-EDP ethanolamide (19,20-DHEA epoxide) (compound 19) is an ω-3 endocannabinoid epoxide with cytokine modulation in neuroinflammation studies, antiangiogenic effects in vascular endothelial cells, and vasodilatory effects on coronary arteries.

HY-N12003

19-Hydroxybaccatin V	Biochemical Assay Reagents	Cancer
19-Hydroxybaccatin V (compound 14) is a diterpenoid that can be obtained from Taxus chinensis. 19-Hydroxybaccatin V has potential in cancer research .

HY-W105738

19-Bromononadecanoic acid	PROTAC Linkers	Cancer
19-Bromononadecanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-139120

19(R)-hydroxy Prostaglandin E2 19(R)-Hydroxy PGE2; 19(R)-OH PGE2	Prostaglandin Receptor	Metabolic Disease
19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man. It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor. It has an EC₅₀ value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.

HY-137574

19(R)-Hydroxy prostaglandin E1 19(R)-Hydroxy PGE1	Prostaglandin Receptor	Others
19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations .

HY-N7857

19(R)-Hydroxy-prostaglandin F2α 19(R)-Hydroxy PGF2α	Drug Metabolite	Metabolic Disease
19(R)-Hydroxy-prostaglandin F2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandin F2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.

HY-126989

19-O-Acetylchaetoglobosin A	Arp2/3 Complex	Cancer
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W250795

Maltodextrin, dextrose equivalent 16.5-19.5 Maltodextrin; Dextrin maize starch	Structural Classification Natural Products Endogenous metabolite Source Classification	Environmental Pollutants Biochemical Assay Reagents
Maltodextrin, dextrose equivalent 16.5-19.5 can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-101408

Docosatrienoic Acid 1 Publications Verification cis-13,16,19-docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an K_i of 5 μM.

HY-N8377

Capsiate 4 Publications Verification	Monophenols Capsicum annuum L. Classification of Application Fields Phenols Solanaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	TRP Channel
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1 .

HY-N16395

Jensenone	Phenols Polyphenols Myrtaceae Eucalyptus jensenii Maiden Plants Source Classification	SARS-CoV Virus Protease
Jensenone is an acylphloroglucinol derivative. Jensenone binds to COVID-19 proteinase in molecular docking studies. Jensenone can be used as a COVID-19 Mpro inhibitor .

HY-N8164

19α-Hydroxyasiatic acid	Triterpenes Classification of Application Fields Terpenoids Plants Symplocos chinensis (Lour.) Druce Inflammation/Immunology Disease Research Fields Symplocaceae Source Classification	Elastase
19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity .

HY-113302

19-Hydroxyandrost-4-ene-3,17-dione	Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
19-Hydroxyandrost-4-ene-3,17-dione is a substrate for Corticotropin-lipotropin and Cytochrome P450 19A1.

HY-N8349

19,20-Epoxycytochalasin D	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-N7019

19-Hydroxybufalin	Classification of Application Fields Animals Disease Research Fields Steroids Cancer Source Classification	Others
19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .

HY-N1923

Hypaconine	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Others
Hypaconine is a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp. Hypaconine exhibits strong cardiac activity .

HY-N0969

(Z)-Akuammidine 19-(Z)-Akuammidine; (Z)-Rhazine	Natural Products Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Source Classification	Others
(Z)-Akuammidine ((Z)-Rhazine) is isolated from Gelsemium elegans .

HY-N16573

19-epi-Voacristine	Apocynaceae Structural Classification Alkaloids Tabernaemontana bovina Loureiro Plants Indole Alkaloids Source Classification	Others
19-epi-Voacristine is an indole alkaloid. 19-epi-Voacristine exhibits cytotoxic activity against the A2780 ovarian cancer cell line .

HY-N11076

12E,14-Trien-19-oic acid	Cupressaceae Juniperus communis L. Terpenoids Diterpenoids Plants Source Classification	Others
12E,14-Trien-19-oic acid is a diterpenoid. 12E,14-Trien-19-oic acid can be isolated from Bhutanese medicinal plant, shug chher. 12E,14-Trien-19-oic acid can be used for the research of platelet aggregation .

HY-N10685

3,7,25-Trihydroxycucurbita-5,23-dien-19-al TCD	Triterpenes Structural Classification Anthocyans Flavonoids Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Drug Derivative
3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida .

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	Rosaceae Rosa cymosa (L.) Tratt. Plants	EBV HIV Protease HSV
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .

HY-P0324

Parasin I	Infection Natural Products Classification of Application Fields Animals Disease Research Fields Source Classification	Bacterial
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-N7972

19-Oxocinobufotalin	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Others
19-Oxocinobufotalin is capable of suppressing EMT (Epithelial-mesenchymal transition) and weakening the migratory and invasive potential of PC3 cells .

HY-N10376

Lagunamine 19-Hydroxytubotaiwine	Apocynaceae Alstonia scholaris (L.) R. Br. Plants Source Classification	Others
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

HY-N6918

Steviol-19-O-glucoside	other families Classification of Application Fields Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Source Classification	Others
Steviol-19-O-glucoside is a metabolite of steviol in the steviol glycosides biosynthesis pathway in Stevia rebuadiana .

HY-N0978

1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid	Infection Agrimonia pilosa Ledeb. Triterpenes Classification of Application Fields Terpenoids Rosaceae Metabolic Disease Plants Disease Research Fields Source Classification	Parasite
1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoid that isolated from the plant of Agrimonia Pilosa with antimalarial and antidiabetic activities .

HY-N12253

(19R)-13-Deoxy-19-hydroxyenmein	Terpenoids Labiatae Erythrina sacleuxii Hua Diterpenoids Plants Source Classification	Others
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

HY-N10778

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol	Triterpenes Terpenoids Cucurbitaceae Plants Source Classification Momordica charantia Linn.	Others
(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .

HY-N7017

19-Oxocinobufagin	Classification of Application Fields Animals Metabolic Disease Disease Research Fields Steroids Source Classification	Others
19-Oxocinobufagin is a bufadienolide in toad venom .

HY-N12003

19-Hydroxybaccatin V	Terpenoids Taxaceae Diterpenoids Plants Source Classification Taxus chinensis (Pilger) Rehd.	Biochemical Assay Reagents
19-Hydroxybaccatin V (compound 14) is a diterpenoid that can be obtained from Taxus chinensis. 19-Hydroxybaccatin V has potential in cancer research .

HY-126989

19-O-Acetylchaetoglobosin A	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	Arp2/3 Complex
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

HY-N1597

(19Z)-Normacusine B	Alkaloids Classification of Application Fields Other Alkaloids Labiatae Carpesium cernuum L. Other Diseases Plants Disease Research Fields Source Classification	Others
(19Z)-Normacusine B, Gelsemiurn alkaloids, is a natural product that can be isolated from Gelsemiurn .

HY-N12004

19-Hydroxy-10-deacetylbaccatin III	Terpenoids Taxaceae Diterpenoids Plants Source Classification Taxus chinensis (Pilger) Rehd.	Others
19-Hydroxy-10-deacetylbaccatin III (compound 13) is a taxane with potential antitumor activity. 19-Hydroxy-10-deacetylbaccatin III has weak cytotoxicity against A498 and NCI-H226 cell lines. The study found that the inhibition rates of 30 μg/mL 19-Hydroxy-10-deacetylbaccatin III on A498, NCI-H226 and PC-3 were 16.6% and 32% respectively .

HY-N9104

ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside	Natural Products Acanthaceae Simsia foetida (Cav.) S.F.Blake Plants Source Classification	Others
ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside is a natural product derived from the leaves of Andrographis paniculata that has anti-inflammatory and antiviral activity .

HY-N8385

19,20-Epoxycytochalasin C	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-N8494

ent-Kauran-17,19-dioic acid	Classification of Application Fields Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Other Diseases Diterpenoids Plants Compositae Disease Research Fields Source Classification	Others
ent-Kauran-17,19-dioic acid (16α-Hydro-ent-kauran-17,19-dioic acid) is an ent-kaurane diterpenoid .

HY-N3814

ent-16β,17-Dihydroxykauran-19-oic acid	Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Source Classification	Others
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

HY-N3816

ent-17-Hydroxykaur-15-en-19-oic acid	Terpenoids Diterpenoids Plants Cedrelopsis gracilis J.-F.Leroy Source Classification Salicaceae	Others
ent-17-Hydroxykaur-15-en-19-oic acid is a ent-kaurene diterpene that can be isolated from the leaves of Laetia thamnia L.. ent-17-Hydroxykaur-15-en-19-oic acid was cytotoxic to human prostate LNCaP2 cells with IC₅₀ 17.63 mg/mL .

HY-N1111

Uncaric acid 6β,19α-Dihydroxyursolic acid	Triterpenes Terpenoids Rosaceae Plants Eriobotrya japonica (Thunb.) Lindl. Source Classification	HIV
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity .

HY-N3810

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Terpenoids Pteridaceae Diterpenoids Plants Pteris semipinnata L. Sp. Source Classification	Tyrosinase
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

HY-N3809

ent-11,16-Epoxy-15-hydroxykauran-19-oic acid	Terpenoids Asteraceae Diterpenoids Plants Source Classification	Others
ent-11,16-Epoxy-15-hydroxykauran-19-oic acid is a Diterpenoids product that can be isolated from the herbs of Nouelia insignis .

HY-N9160

ent-3β-Angeloyloxykaur-16-en-19-oic acid	Terpenoids Asteraceae Diterpenoids Plants Wedelia trilobata (L.) Hitchc. Source Classification	Others
ent-3β-Angeloyloxykaur-16-en-19-oic acid is a Diterpenoids product that can be isolated from the herbs of Wedelia trilobata .

HY-N8887

ent-17-Hydroxykaura-9(11),15-dien-19-oic acid	Terpenoids Diterpenoids Senna siamea (Lamarck) H. S. Irwin & Barneby Plants Compositae Source Classification	Others
ent-17-Hydroxykaura-9(11),15-dien-19-oic acid is a Diterpenoids product that can be isolated from the herbs of Wedelia trilobata .

HY-N12418

(20S)-18,19-Dehydrocamptothecin	Alkaloids Other Alkaloids Plants Icacinaceae Source Classification	Others
(20S)-18,19-Dehydrocamptothecin is a natural product that can be isolated from Nothapodytes Foetida .

HY-N1611

19,20-(E)-Vallesamine (E)-Vallesamine	Apocynaceae Tabernaemontana corymbosa Roxburgh ex Wallich Plants Indole Alkaloids Source Classification	Others
19,20-(E)-Vallesamine is an indole alkaloid compound isolated from the stems of Ervatamia yunnanensis .

HY-N9290

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid	Terpenoids Pteridaceae Diterpenoids Pteris semipinnata L. Sp. Plants Source Classification	Others
ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid is a Diterpenoids product that can be isolated from the herbs of Pteris semipinnata .

HY-N9118

(E)-8α-Hydroxylabda-13(16),14-dien-19-yl coumarate	Cupressaceae Terpenoids Diterpenoids Plants Metasequoia glyptostroboides Hu & W. C. Cheng Source Classification	Others
(E)-8α-Hydroxylabda-13(16),14-dien-19-yl coumarate is a Diterpenoids product that can be isolated from the herbs of Metasequoia glyptostroboides .

HY-N8555

ent-Kaurane-16β,19,20-triol	Terpenoids Sanguisorba officinalis L. Rubiaceae Diterpenoids Plants Source Classification	Others
ent-Kaurane-16β,19,20-triol is a Diterpenoids product that can be isolated from the herbs of Euphorbia ehracteolata .

HY-N1760

3β, 19α-Dihydroxy-6-oxo-urs-12-en-23-al-28-oic acid	Uncaria tomentosa (Willd. ex Schult.) DC. Triterpenes Terpenoids Rubiaceae Plants Source Classification	Others
3β, 19α-Dihydroxy-6-oxo-urs-12-en-23-al-28-oic acid (compound 1) is a triterpene that can be isolated from Uncaria .

HY-N9025

ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester	Terpenoids Pteridaceae Diterpenoids Pteris semipinnata L. Sp. Plants Source Classification	Others
ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester is a Diterpenoids product that can be isolated from the herbs of Pteris semipinnata .

HY-N12547

19-O-D-Carboxyglucopyranosyl-12-O-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene	Terpenoids Labiatae Diterpenoids Plants Ondetia linearis Benth. Source Classification	Others
19-OD-Carboxyglucopyranosyl-12-O--D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene was isolated from the acetone-soluble extract of Clerodendrum bungei roots .

HY-N8987

(3β,7β)-3,7,23,24-Tetrahydroxycucurbita-5,25-dien-19-al	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Others
(3β,7β)-3,7,23,24-Tetrahydroxycucurbita-5,25-dien-19-al (compound 3) is a cucurbitane-type triterpenoid isolated from the vines and leaves of Momordica charantia .

HY-N1644

2,16,19-Kauranetriol 2-O-β-D-allopyranoside	Classification of Application Fields Terpenoids Pteridaceae Other Diseases Diterpenoids Plants Disease Research Fields Archidendron jiringa Source Classification	Others
2,16,19-Kauranetriol 2-O-β-D-allopyranoside is an ent-kaurane glycoside, which can be isolated from the fronds of Pteris cretica .

HY-N1792

3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid	Triterpenes Terpenoids Rubiaceae Uncaria sessilifructus Roxb. Plants Source Classification	Others
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoids product that can be isolated from the herbs of Uncaria sessilifructus. .

HY-N2647

5,19-Epoxy-25-methoxycucurbita-6,23-dien-3-ol	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Others
5,19-Epoxy-25-methoxycucurbita-6,23-dien-3-ol is a Triterpenoids product that can be isolated from the fresh fruits of Momordica charantia L. .

HY-N4241

Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)-	other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Disease Research Fields Source Classification	Others
Kauran-18-oic acid, 16,17,19-trihydroxy-, (4α)- (compound 5) is a endogenous ent-kaurane diterpene compound in green coffee beans, providing direct chemical indicators of low-quality coffee .

HY-N3821

ent-7α,9-Dihydroxy-15-oxokaur-16-en-19,6β-olide	Terpenoids Labiatae Carpesium cernuum L. Diterpenoids Plants Source Classification	Others
ent-7α,9-Dihydroxy-15-oxokaur-16-en-19,6β-olide is a Diterpenoids product that can be isolated from the rhizomes of Isodon yuennanensis .

Cat. No.	Product Name	Chemical Structure

HY-145119AS

Mindeudesivir hydrobromide
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against *COVID-19, and is the first domestically produced deuterium targeting the COVID*-19 .

HY-131968

BMS-986202

1 Publications Verification

BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC₅₀ value of 0.19 nM and a K_i of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC₅₀ value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium .

HY-W015309S1

Decanoic acid-d19
Decanoic acid-d₁₉9 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects .

HY-15330

Vitamin D2-d3
Vitamin D2-d₃ (Ergocalciferol-d₃) is the deuterium labeled vitamin D2 (HY-76542), where the C-6 and C-19 protons are replaced by deuterium. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D .

HY-14648S

Dexamethasone-d5

Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses .

HY-B0402S1

Amantadine-d6

Amantadine-d₆ is the deuterium labeled Amantadine . Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

HY-W008772S

4-Hydroxymephenytoin-d3
4-Hydroxymephenytoin-d₃ is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate .

HY-13011S

Alectinib-d8
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-B0260S4

Methylprednisolone-d2
Methylprednisolone-d₂ is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine (HY-17589A). Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-135853S

Molnupiravir-d7
Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-B0507S

Sulfathiazole-d4

Sulfathiazole-d₄ is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

HY-14648S5

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14541S

Olanzapine-d3
Olanzapine-d₃ (LY170053-d₃) is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic .

HY-Y0136S1

3-Indoleacetonitrile-d4

3-Indoleacetonitrile-d₄ is deuterium labeled 3-Indoleacetonitrile (HY-Y0136). 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.

HY-B0258S

Gemfibrozil-d6
Gemfibrozil-d₆ is the deuterium labeled Gemfibrozil. Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

HY-D0856S

Bis-Tris-d19
Bis-Tris-d₁₉ is the deuterium labeled Bis-Tris . Bis-Tris is a commonly used buffer .

HY-W008816S

Nonan-1-ol-d19
n-Nonyl Alcohol-d₁₉ is the deuterium labeled Nonan-1-ol .

HY-W004261S

Nonadecanoic acid-d37
Nonadecanoic acid-d₃₇ is the deuterium labeled Nonadecanoic acid. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis to defence .

HY-150773S1

Guanosine triphosphate-d14 dilithium
Guanosine triphosphate-d₁₄ (GTP-d₁₄) dilithium is a deuterium labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19 .

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-14648S2

Dexamethasone-d4

Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14187S

Amiodarone-d10 hydrochloride
Amiodarone-d₁₀ (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-N6787S

5,6-Dihydro-5-methyluracil-d6
5,6-Dihydro-5-methyluracil (Dihydrothymine)-d₆ is the deuterium labeled 5,6-Dihydro-5-methyluracil (HY-N6787). 5,6-Dihydro-5-methyluracil is an intermediate breakdown product of Thymine (HY-W010450). 5,6-Dihydro-5-methyluracil can be used as a marker of DNA damage. 5,6-Dihydro-5-methyluracil can be used for the research of COVID-19 .

HY-117057S

Hexaenoic acid-d6

Hexaenoic acid-d₆ is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .

HY-B0725S

Doxepin-d3 hydrochloride
Doxepin-d₃ (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 .

HY-115340S

Decanoic acid-d19 sodium
Decanoic acid-d₁₉ (sodium) is the deuterium labeled Decanoic acid .

HY-143954S

Epinephrine impurity 19-d3 hydrochloride
Epinephrine impurity 19-d₃ (hydrochloride) is the deuterium labeled Epinephrine impurity 19 .

HY-N6692S

Diacetoxyscirpenol-13C19
Diacetoxyscirpenol- ¹³C₁₉ is ¹³C labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .

HY-13017S1

Ivacaftor-d19
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-B0260S3

Methylprednisolone-d7
Methylprednisolone-d₇ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .

HY-B0260S

Methylprednisolone-d3
Methylprednisolone-d₃ is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .

HY-B0260S2

Methylprednisolone-d4
Methylprednisolone-d₄ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .

HY-B0180S1

Imiquimod-d9
Imiquimod-d₉ is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-B0180S

Imiquimod-d6
Imiquimod-d₆ is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-B0260S6

Methylprednisolone-d3-1
Methylprednisolone-d₃-1 (U 7532-d₃-1) is the deuterium labeled Methylprednisolone (HY-B0260). Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-N0169S

Hyodeoxycholic acid-d5
Hyodeoxycholic acid-d₅ is the deuterium labeled Hyodeoxycholic acid. Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.

HY-130353S

Desethyl Amiodarone-d4 hydrochloride

Desethyl Amiodarone-d₄ (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-13011S1

Alectinib-d6
Alectinib-d₆ is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-146916S

19:0-12:0-19:0 TG-d5
19:0-12:0-19:0 TG-d₅ is deuterium labeled 19:0-12:0-19:0 TG.

HY-145012S

W-19-d4 hydrochloride
W-19-d₄ (hydrochloride) is the deuterium labeled W-19 hydrochloride .

HY-163313S

Tyk2-IN-19-d6
Tyk2-IN-19-d6 (compound 15) is the deuterium labeled Tyk2-IN-19 (HY-163313) .

HY-152024S

Sebaleic acid-d19
Sebaleic acid-d₁₉ is the deuterium labeled Sebaleic acid (HY-W746683).

HY-146855S

19:0 Lyso PG-d5
19:0 Lyso PG-d₅ is deuterium labeled 19:0 Lyso PG.

HY-146844S

19:0 Lyso PE-d5
19:0 Lyso PE-d₅ is deuterium labeled 19:0 Lyso PE.

HY-W783639S

Bzo-poxizid-d9
Bzo-poxizid-d₉ (5C-MDA-19-d₉, Petyl MDA-19-d₉) is deuterium labeled Bzo-poxizid. Bzo-poxizid is a synthetic cannabinoid that is a psychoactive substance .

HY-W728065S

NITROSO-STG-19-d4
NITROSO-STG-19-d₄ (NTTP-d₄) is a deuterium labeled NITROSO-STG-19.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15579BG

MMAF sodium Monomethylauristatin F sodium	Microtubule/Tubulin ADC Payload	Cancer
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-15579G

MMAF Monomethylauristatin F	Microtubule/Tubulin ADC Payload	Cancer
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-138170GL

ALC-0315 (GMP Like)	Liposome SARS-CoV	Infection
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .

HY-126675G

AS2863619	CDK TGF-beta/Smad Apoptosis	Inflammation/Immunology
AS2863619 GMP is AS2863619 (HY-126675) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS2863619 is an orally active *CDK8/19* inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets *Stat5a-CDK8/19* to promote the differentiation of CD4 ⁺ T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects .

HY-17356G

Fenofibrate	Cytochrome P450 PPAR Autophagy	Cardiovascular Disease
Fenofibrate (GMP) is Fenofibrate (HY-17356) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for *CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4*, respectively.

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