Acly - ATP citrate lyase Gene

Also Known as A730098H14Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 104112

About Acly

Chromosome 11: 100,367,179-100,418,826 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 283 orthologues and is associated with 2 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 333.), mammary gland adult (RPKM 298.7) and 24 other tissues.

Summary

Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACLY (ATP Citrate Lyase). [provided by Alliance of Genome Resources, Apr 2022]

Acly Products (2)

mRNA Protein Name
NM_001199296.1 NP_001186225.1 ATP-citrate synthase isoform 1
NM_134037.3 NP_598798.1 ATP-citrate synthase isoform 2
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATP citrate synthase activity IDA
IDA: Inferred from direct assay
25450640 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acly Protein Structure

PLN02235

PLN02235: cl42902 (0 - 418)

PLN02522

PLN02522: cl31895 (478 - 1083)

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  • 1091 a.a.
Protein Preferred Names Protein Names

ATP-citrate synthase

  • ATP-citrate (pro-S-)-lyase

  • citrate cleavage enzyme

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Acly NCBI NCBI:47