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Dynamic epigenetic changes during kidney development

DNA Metabolism And Repair Multiprotein Complexes and Disease Intercellular Communication & Diseases Cellular Stress

Kidney development depends on dynamic epigenetic regulation that converts nephron progenitor cells into specialized epithelial and stromal lineages without changing their DNA sequence. DNA methylation, histone modifications, ATP-dependent chromatin remodeling, and higher-order enhancer-promoter contacts determine which developmental genes remain accessible as progenitors self-renew, commit, and differentiate. Research has moved from candidate regulators to genome-wide chromatin accessibility, methylome, and multimodal profiling, revealing that the renal epigenome changes with cell identity and developmental time. Developmental competence must be maintained long enough to generate an adequate nephron pool and then relinquished so that differentiation can proceed. This work is important because errors in nephron progenitor maintenance or differentiation can alter nephron endowment and increase susceptibility to renal disease[1][2].

A central mechanism is the controlled transition between permissive and repressive chromatin. Nephron progenitors maintain lineage competence through transcription-factor networks and chromatin states that must later be remodeled as renal vesicles and nephron segments form. DNA methylation contributes to progenitor maturation, while Polycomb proteins EZH1 and EZH2, histone deacetylases HDAC1 and HDAC2, and SWI/SNF-related remodeling activities regulate accessibility and transcriptional programs. Active enhancers and promoters communicate through long-range chromatin interactions, allowing distal regulatory elements to control developmental genes. The same regulator can have stage-dependent effects because its genomic partners and accessible binding sites change during lineage commitment. The timing and cell specificity of these events are as important as the presence of any single epigenetic mark[1][2][3].

These mechanisms provide experimental and translational applications. ATAC-seq and single-cell ATAC-seq identify accessible regulatory regions and infer transcription-factor activity; methylome profiling tracks stable or transitional silencing; and Hi-C-related approaches map long-range regulatory contacts. Integrating these layers with single-cell transcriptomics can reconstruct developmental trajectories and nominate regulatory elements linked to congenital anomalies or kidney-function risk loci. Kidney organoids offer a complementary system for testing candidate regulators, although their maturation and cellular composition do not fully reproduce fetal development. Comparing organoid chromatin states with reference fetal tissue can expose missing lineages, premature differentiation, or persistent progenitor programs and guide protocol improvement. Epigenomic maps can also clarify how developmental pathways are reactivated during repair, fibrosis, and tumorigenesis[2][3][4].

Important gaps remain in human developmental material, temporal resolution, and causal validation. Much mechanistic knowledge derives from mouse models, bulk tissue, or in vitro systems in which changing cell composition can mimic changes within a cell type. Newly available single-cell and spatial approaches must therefore be paired with lineage tracing and targeted perturbation to distinguish regulatory drivers from marks that merely accompany differentiation. Future studies should define stage-specific enhancer networks, determine how metabolic and environmental signals influence chromatin enzymes, and compare normal fetal development with organoids and diseased tissue. They must also resolve whether a candidate epigenetic intervention expands functional nephron progenitors or merely delays differentiation and produces abnormal tissue. Such work may identify when epigenetic errors become irreversible and where controlled modulation could improve regenerative or congenital-kidney-disease strategies Human reference atlases spanning early progenitors through mature nephron segments will be essential for interpreting organoid and disease-associated deviations and testing causal regulators across species[1][2][4].

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Cat. No. Product Name Information Application Publication
HY-13030 (+)-JQ-1
(+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.
Epigenetic Reader Domain   Autophagy   Ligands for Target Protein for PROTAC   SWI/SNF Complex  
Neurological, Eye or Ear Disease   Leukemia/Lymphoma/Myeloma  
306
HY-A0281 4-Phenylbutyric acid
4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
HDAC   Virus Protease  
Lung Cancer   Breast Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   SARS-CoV-2 Infection  
259
HY-15144 Trichostatin A
Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.
Organoid   HDAC  
Breast Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer  
195
HY-A0004 Decitabine
Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity.
DNA Methyltransferase   Apoptosis   Nucleoside Antimetabolite/Analog  
Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Urogenital Cancer   Non-Small Cell Lung Cancer   Acute Myeloid Leukemia   SARS-CoV-2 Infection   Rheumatoid Arthritis  
177
HY-10221 Vorinostat
Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
HDAC   Autophagy   Mitophagy   Filovirus   Apoptosis   HPV  
Neurological, Eye or Ear Disease   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Lung Fibrosis  
171
HY-10586 5-Azacytidine
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
Organoid   Nucleoside Antimetabolite/Analog   DNA Methyltransferase   Bacterial   Autophagy   Antibiotic  
Lung Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Bacterial Infection   SARS-CoV-2 Infection   Rheumatoid Arthritis  
139
HY-13470 GSK126
GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM.
Histone Methyltransferase  
Leukemia/Lymphoma/Myeloma  
104
HY-L005 Epigenetics Compound Library
Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases. MCE provide a unique collection of 2,010 epigenetics-related compounds that can be used in the research of the related diseases.

Signaling Pathway Targeting Libraries

102
HY-13803 Tazemetostat
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
Histone Methyltransferase   Apoptosis  
Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation  
96
HY-L004 Cell Cycle/DNA Damage Compound Library
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair. MCE owns a unique collection of 3,470 cell cycle/DNA damage-related compounds which can be used in the research of the same.

Signaling Pathway Targeting Libraries

93
HY-12163 Entinostat
Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively.
HDAC   Autophagy   Apoptosis  
91
HY-L003 Apoptosis Compound Library
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease. MCE designs a unique collection of 3,590 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Signaling Pathway Targeting Libraries

90
HY-10224 Panobinostat
Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma.
HDAC   Autophagy   HIV   Apoptosis  
Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Small Cell Lung Cancer   Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
89
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,884 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L024 Histone Modification Research Compound Library
A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases. MCE owns a unique collection of 924 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Signaling Pathway Targeting Libraries

85
HY-L040 Anti-diabetic Compound Library
Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage. The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes. MCE Anti-diabetic Compound Library owns a unique collection of 1,156 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Disease Focused Libraries

84
HY-L051 Ferroptosis Compound Library
Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 1,232 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Signaling Pathway Targeting Libraries

84
HY-L005M Epigenetics Compound Library Mini
Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer. MCE provide a unique collection of 296 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.

Signaling Pathway Targeting Libraries

83
HY-L038 Differentiation Inducing Compound Library
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method. MCE Differentiation Inducing Compound Library contains a unique collection of 2,537 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Signaling Pathway Targeting Libraries

83
HY-L112 Chemotherapy Drug Library
Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs. Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 158 chemotherapy drugs, which is a useful tool for cancer treatment research.

Disease Focused Libraries

83
HY-L135 Cancer Stem Cells Compound Library
With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on. Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment. MCE supplies a unique collection of 3,499 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

Compound Characteristic Classified Libraries

83
HY-L145 Antihypertensive Compound Library
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 925 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Disease Focused Libraries

83
HY-L162 Cell Death Library
Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc. MCE designs a unique collection of 3,812 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.

Compound Characteristic Classified Libraries

83
HY-L162M Cell Death Inhibitor Library Mini
Cell death is a core biological process that maintains homeostasis in multicellular organisms, playing a dual role in life activities. On one hand, cell death participates in physiological processes such as cell renewal and damage repair through precise regulation; on the other hand, it actively eliminates damaged, infected, or cancerous cells, thereby blocking pathological progression and preserving organism health. Cell death not only ensures the normal development and growth regulation of organisms but is also closely associated with the occurrence and development of various diseases. Numerous studies have shown that specific types of programmed cell death play critical roles in disease progression, providing an important theoretical basis for developing novel therapeutic strategies by regulating cell death pathways. MCE offers 23 types of commonly used cell death inhibitors, such as apoptosis, ferroptosis, pyroptosis, and cuproptosis, suitable for use as positive controls in the study of novel cell death mechanisms.

Signaling Pathway Targeting Libraries

83
HY-L174 Macrophage Related Compound Library
Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 275 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L194 Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library
Heat-clearing and detoxification is a specific treatment method in the research of traditional Chinese medicine (TCM), which is clinically used to treat infectious diseases with remarkable effect. Over the past decades, the research of heat-clearing and detoxification treatment has been one of the most active fields of combining traditional Chinese and western medicines, and has made remarkable achievements. Nowadays, the application field of heat-clearing and detoxification traditional Chinese medicine is not only limited to antibacterial and antiviral, but also has made progress in the research fields of anti-inflammatory reaction, anti-endotoxin, anti-peroxidative damage, anti-inflammatory cytokines, enhancement of immune function, protection of cellular organelles, and maintenance of calcium homeostasis. In addition to this, clearing heat and removing toxins has also made significant research progress in non-infectious diseases, for example, in tumors, cardiovascular diseases, renal diseases, blood diseases, geriatrics, and diabetes, all of which have shown good curative effect. MCE can supply 1,279 monomer component from more than a hundred sources of heat-clearing and detoxification TCM, which can be used in TCM studies, drug development and mechanism-based studies.
83
HY-L201 Cell Proliferation Compound Library
Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others. MCE collects 3,579 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Signaling Pathway Targeting Libraries

83
HY-L203 Methylation Compound Library
Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation. MCE contains 346 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.
83
HY-L229 Nephrotoxicity Compound Library
Kidneys are one of the vital organs in the human body. Due to their exposure to higher concentrations of circulating drugs or metabolites, they are highly susceptible to drug-induced renal injury (DIRI). According to statistics, drug-induced kidney injury accounts for approximately 20% of nephrotoxicity reports and can lead to acute kidney injury (AKI), chronic kidney disease (CKD), or even end-stage renal disease (ESRD). Early detection of drug nephrotoxicity is crucial for preventing irreversible kidney damage. Research into its mechanisms can help optimize clinical medication by adjusting dosages or avoiding combinations of nephrotoxic drugs. Additionally, predicting drug-induced nephrotoxicity in early drug development can reduce the risk of late-stage R&D failure. MCE offers 159 nephrotoxicity compounds that have been clearly reported by the FDA to be associated with kidney injury. This library can be used for studying molecular mechanisms of nephrotoxicity or developing novel biomarkers.
83
HY-13755 Sulforaphane
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties.
HDAC   Keap1-Nrf2   Apoptosis   Bcl-2 Family   Caspase   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease  
77
HY-15149 Romidepsin
Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis.
HDAC   Apoptosis  
Lung Cancer   Triple-Negative Breast Cancer  
75
HY-10585A Valproic acid sodium
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.
Organoid   HDAC   Autophagy   Mitophagy   HIV   Notch   Apoptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
69
HY-10585 Valproic acid
Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.
Organoid   HDAC   Autophagy   Mitophagy   HIV   Notch   Apoptosis   Endogenous Metabolite  
Infection   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Respiratory Disease   Small Cell Lung Cancer  
69
HY-119374 BRM/BRG1 ATP Inhibitor-1
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity.
SWI/SNF Complex  
Cancer  
40
HY-112288 C188-9
C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia.
STAT   Apoptosis   DNA Methyltransferase  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   Obesity  
36
HY-10442 3-Deazaneplanocin A
3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor. 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity.
Histone Methyltransferase   S-adenosylhomocysteine hydrolase (SAHH)   Orthopoxvirus  
Respiratory Disease   Leukemia/Lymphoma/Myeloma   Glucose Metabolism   Non-Small Cell Lung Cancer   Orthopoxvirus Infection  
35
HY-101563 GSK3326595
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma.
Histone Methyltransferase   SARS-CoV   MDM-2/p53   CDK   Apoptosis  
Breast Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection  
33
HY-15593 Pinometostat
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.
Histone Methyltransferase  
Leukemia/Lymphoma/Myeloma   SARS-CoV-2 Infection  
33
HY-13500 GSK343
GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
Histone Methyltransferase   Autophagy  
Leukemia/Lymphoma/Myeloma  
32
HY-10587 BIX-01294
BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells.
Histone Methyltransferase   Autophagy  
Leukemia/Lymphoma/Myeloma  
27
HY-111558 Bobcat339
Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.
DNA Methyltransferase   TET Protein  
Leukemia/Lymphoma/Myeloma   Rheumatoid Arthritis  
26
HY-135146 GSK-3484862
GSK-3484862 is a highly potent non-covalent inhibitor and demethylating agent of DNMT1. GSK-3484862 induces genome-wide DNA demethylation, including the regulatory elements of DNMT3B and the promoter region of TERT, and significantly inhibits cell viability, growth, proliferation and self-renewal. GSK-3484862 blocks the transformation of young AT2 cells, induces apoptosis, and generates transcriptomic features similar to those of senescent cells. GSK-3484862 is widely used in studies related to lung cancer, oral squamous cell carcinoma and lung adenocarcinoma.
DNA Methyltransferase   Apoptosis  
Lung Cancer   Breast Cancer   Leukemia/Lymphoma/Myeloma  
26
HY-B0350A Sodium butyrate
Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity.
HDAC   Autophagy   Apoptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Breast Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   SARS-CoV-2 Infection  
25
HY-13962 SGI-1027
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
DNA Methyltransferase   Apoptosis  
Digestive System Disease   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation   Rheumatoid Arthritis  
19
HY-145388 AU-15330
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity.
PROTACs   SWI/SNF Complex  
15
HY-139664 GSK-3685032
GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition.
DNA Methyltransferase  
Leukemia/Lymphoma/Myeloma   Rheumatoid Arthritis  
15
HY-13642 RG108
RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC50=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.
DNA Methyltransferase  
Leukemia/Lymphoma/Myeloma   Rheumatoid Arthritis  
14
HY-13765 6-Thioguanine
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.
SARS-CoV   Deubiquitinase   DNA Methyltransferase   Autophagy   Apoptosis   Endogenous Metabolite  
Digestive System Disease   Leukemia/Lymphoma/Myeloma   Viral Infection   Digestive System Inflammation   SARS-CoV-2 Infection   Rheumatoid Arthritis  
13
HY-128359 ACBI1
ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis.
PROTACs   SWI/SNF Complex   Apoptosis  
Non-Small Cell Lung Cancer  
11
HY-136328 EZM0414 TFA
EZM0414 (SETD2-IN-1) TFA is the TFA salt form of EZM0414 (HY-144858). EZM0414 TFA is a potent, selective, orally active inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 TFA can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
Histone Methyltransferase  
10
HY-W127530 α-Tocopherol phosphate disodium
α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity.
Apoptosis   Reactive Oxygen Species (ROS)  
Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism  
8
HY-N0739 Betaine chloride
Betaine chloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.
Endogenous Metabolite  
6
HY-B0710 Betaine
Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity.

Source: Widespread

Environmental Pollutants   Endogenous Metabolite  
Metabolic or Endocrine Disease  
6
HY-B0504S Creatinine-d3
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Cancer   Metabolic or Endocrine Disease  
5
HY-12409 PFI-3
PFI-3, a chemical probe, is a selective, potent and cell-permeable SMARCA2/4 bromodomain inhibitor with a Kd of 89 nM.
SWI/SNF Complex  
Cancer  
5
HY-109108 Valemetostat
Valemetostat (DS-3201), a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat can be used for the research of relapsed/refractory peripheral T-cell lymphoma.
Histone Methyltransferase  
Prostate Cancer   Leukemia/Lymphoma/Myeloma  
5
HY-P80920 TREM2 Antibody
TREM2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TREM2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

5
HY-W040821 DL-Homocysteine
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
4
HY-P1454A Fz7-21 TFA
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids.
Wnt  
Cancer  
3
HY-P1454 Fz7-21
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids.
Wnt  
Cancer  
3
HY-W012078 5-Methyl-2'-deoxycytidine
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells.
DNA Methyltransferase   Endogenous Metabolite  
Leukemia/Lymphoma/Myeloma  
3
HY-42682 D(+)-Galactosamine hydrochloride
D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
Drug Derivative  
Inflammation or Immune System Disease  
3
HY-144835 Camibirstat
FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia.
Oxidative Phosphorylation   SWI/SNF Complex  
Acute Myeloid Leukemia  
3
HY-139611 Navlimetostat
Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC50 of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study.
Histone Methyltransferase  
3
HY-W008091R 5-Methylcytosine (Standard)
5-Methylcytosine (Standard) is the analytical standard of 5-Methylcytosine (HY-W008091). This product is intended for research and analytical applications. 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma.
Reference Standards   DNA/RNA Synthesis   Endogenous Metabolite  
Cancer  
2
HY-P0254A Kisspeptin-10, human TFA
Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.
Kisspeptin Receptor  
Breast Cancer   Cardiovascular Disease   Obesity   Lung Fibrosis  
2
HY-B1941 4-tert-Octylphenol
4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology.
Endogenous Metabolite   Apoptosis   DNA/RNA Synthesis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation  
2
HY-W008091 5-Methylcytosine
5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma.

Source: prokaryotes and eukaryotes

DNA/RNA Synthesis   Endogenous Metabolite  
Colorectal Cancer   Liver Cancer  
2
HY-P0254 Kisspeptin-10, human
Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.
Kisspeptin Receptor  
Blood or Cardio-cerebrovascular Disease  
2
HY-144896 FHT-1015
FHT-1015 is a selective SMARCA4 (IC50 = 4 nM) and SMARCA2 (IC50 = 5 nM) (also known as BRG1 and BRM) inhibitor. FH-1015 is an allosteric inhibitor that causes conformation change in the BRG1/BRM protein upon interaction with an allosteric site, inhibiting ATPase activity. FH-1015 interferes with tumor cell growth and migration. FH-1015 can be studied in research for uveal melanoma and hematologic cancer.
SWI/SNF Complex  
Leukemia/Lymphoma/Myeloma  
2
HY-B1472 Deoxycorticosterone acetate
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria.
Mineralocorticoid Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
2
HY-163410 AU-24118
AU-24118 is an orally active PROTAC degrader that recruits cereblon to target the degradation of SMARCA2, SMARCA4 and PBRM1. AU-24118 impairs the chromatin accessibility of oncogenic transcription factors, inhibits colony formation, dislodges chromatin-bound transcription factors, attenuates downstream signal transduction, induces apoptosis, and exerts antiproliferative and cytotoxic effects. AU-24118 can be used in research related to castration-resistant prostate cancer, colorectal cancer, small cell lung cancer and multiple myeloma (including the t (4;14) subtype).
PROTACs   SWI/SNF Complex   Apoptosis  
Colorectal Cancer   Prostate Cancer   Small Cell Lung Cancer   Multiple Myeloma  
2
HY-K0310 Mouse CD8+ Cell Positive Selection Kit

MCE Mouse CD8+ Cells Positive Selection Kit is designed for the isolation of CD8+ cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

Cell Biology Cell Isolation

2
HY-K0353 Human CD3/CD28 T Cell Activation Magnetic Beads

MCE Human CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

Cell Biology Cell Isolation

2
HY-113845 (+)-Intermedine
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
Others  
Neurological, Eye or Ear Disease  
1
HY-P1682 Balixafortide
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.
CXCR   Arrestin  
1
HY-P1108 Astressin 2B
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2.
CRFR  
Digestive System Disease   Anxiety or Fear-Related Disease  
1
HY-P10899 ETTAC-2
ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research.
PROTACs   TGF-beta/Smad  
Urogenital Disease  
1
HY-A0248A Polymyxin B1
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.

Source: Bacilus polymyxa

Bacterial  
Infection  
1
HY-P1108A Astressin 2B TFA
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2.
CRFR  
Digestive System Disease   Anxiety or Fear-Related Disease   Digestive System Inflammation  
1
HY-126437H Poly-L-lysine hydrobromide (MW 4000-15000)
Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery.
Biochemical Assay Reagents  
1
HY-133168 Englerin A
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.
TRP Channel  
Cancer  
1
HY-145446 SGC-SMARCA-BRDVIII
SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts.
SWI/SNF Complex  
Obesity  
1
HY-P99023 Girentuximab
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC).

Species: Human

Carbonic Anhydrase  
Cancer  
1
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis.
Endothelin Receptor   Integrin  
Neurological, Eye or Ear Disease  
1
HY-151623 ACBI2
ACBI2 is a highly potent and orally active VHL PROTAC SMARCA2 degrader (EC50: 7 nM), which selectively degrades SMARCA2 with a DC50 value of 1 nM in RKO cells. ACBI2 can be used in the research of lung cancer.
PROTACs   SWI/SNF Complex  
Lung Cancer  
1
HY-Y0537E Potassium chloride, for cell culture
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells.
Environmental Pollutants   Biochemical Assay Reagents   Potassium Channel   Calcium Channel  
Neurological, Eye or Ear Disease  
1
HY-158301 MY-1B
MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.
DNA Methyltransferase   Ligands for E3 Ligase   RNA MTase  
Prostate Cancer  
1
HY-P80034 Bmi-1 Antibody (YA821)
Bmi-1 Antibody (YA821) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bmi-1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

1
HY-K0306 Mouse CD3+ T Cells Negative Selection Kit

MCE Mouse CD3+ T Cells Negative Selection Kit is designed for the isolation of CD3+ T cells from single cell suspensions of mouse spleen cells and lymph nodes.

Cell Biology Cell Isolation

1
HY-K0307 Mouse CD4+ T Cells Negative Selection Kit

MCE Mouse CD4+ T Cells Negative Selection Kit is designed for the isolation of CD4+ T cells from single cell suspensions of mouse spleen cells and lymph nodes.

Cell Biology Cell Isolation

1
HY-K0350 Mouse Neutrophil Negative Selection Kit

MCE Mouse Neutrophil Negative Selection Kit can isolate neutrophils from single-cell suspensions of mouse bone marrow or other tissue samples.

Cell Biology Cell Isolation

1
HY-K6105 Human Gastric Cancer Organoid Kit

MCE Human Gastric Cancer Organoid Kit contains Gastric Cancer Organoid Basal Medium A, Gastric Cancer Organoid Supplement B (50×), Gastric Cancer Organoid Supplement C (250×). This product can be used to efficiently construct human gastric cancer organoid.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

1
HY-B0504S5 Creatinine-15N
Creatinine-15N (NSC13123-15N) is the 15N-labeled Creatinine (HY-B0504). Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-N3674 Dalbergioidin
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM.
TGF-beta/Smad  
Inflammation or Immune System Disease  
/
HY-P11609 TGFβ1-IN-4
TGFβ1-IN-4 is a TGF-β1 inhibitor. TGFβ1-IN-4 inhibits myofibroblast activation and epithelial-mesenchymal transition in vitro. TGFβ1-IN-4 alleviates renal fibrosis in a mouse model of renal fibrosis. TGFβ1-IN-4 can be used for research on fibrotic diseases such as renal fibrosis.
TGF-beta/Smad  
Metabolic or Endocrine Disease  
/
HY-P2253 H3K27(Me2) (15-34)
H3K27(Me2) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).
Histone Demethylase  
Cancer  
/
HY-182569 FR 111142
FR 111142 is an angiogenesis inhibitor (IC50 = 18.4 μM) and has anti-inflammatory activity (IC50 = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS (HY-D1056)-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer, inflammatory diseases.

Source: Phoma sp. NTOU4195

VEGFR  
Cancer   Inflammation or Immune System Disease  
/
HY-170906S MAT2A-IN-23
MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC50 of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP−/−) cell proliferation with with an IC50 of 47 nM.
Methionine Adenosyltransferase (MAT)  
Cancer  
/
HY-N10438 Ganodermaones B
Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression.

Source: Ganoderma lucidum (Curtis) P. Karst.

Integrin  
Inflammation or Immune System Disease  
/
HY-P2252 H3K27(Me) (15-34)
H3K27(Me) (15-34), a histone peptide, is a repressive chromatin markderived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).
Histone Methyltransferase  
Cancer  
/
HY-12008S1 Erlotinib-13C6 hydrochloride
Erlotinib-13C6 hydrochloride (CP-358774-13C6 hydrochloride) is the 13C-labeled Erlotinib Hydrochloride (HY-12008). Erlotinib (CP-358774) Hydrochloride is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib Hydrochloride also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib Hydrochloride blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib Hydrochloride inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib Hydrochloride is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib Hydrochloride can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis.
Isotope-Labeled Compounds   EGFR   OAT   ERK   GSK-3   β-catenin  
Gastric Cancer   Pancreatic Cancer   Renal Disease   Non-Small Cell Lung Cancer   Lung Adenocarcinoma  
/
HY-W700452 Y-27632-d4 hydrochloride hydrate
Y-27632-d4 hydrochloride hydrate is the deuterium labeled Y-27632 hydrochloride hydrate (HY-10071A). Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
Isotope-Labeled Compounds   ROCK   Apoptosis  
Cancer  
/
HY-W127530R α-Tocopherol phosphate disodium (Standard)
α-Tocopherol phosphate (Standard) (alpha-Tocopherol phosphate (Standard)) disodium is the analytical standard of α-Tocopherol phosphate disodium (HY-W127530). This product is intended for research and analytical applications. α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity.
Reference Standards   Apoptosis   Reactive Oxygen Species (ROS)  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-117285 Medermycin
Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively.

Source: Streptomyces albolongus strain CA-186053

Antibiotic   Bacterial  
Cancer   Infection  
/
HY-P11728 Peptide E5
Peptide E5 is an antagonist targeting the CXCR4/CXCL12 axis. Peptide E5 blocks the CXCR4/CXCL12 axis, downregulates CXCR4 expression, and inhibits the phosphorylation of downstream Akt and Erk. Peptide E5 induces apoptosis, suppresses migration and adhesion of breast cancer cells. Peptide E5 inhibits CXCL12-mediated endothelial progenitor cell recruitment, thereby suppressing tumor angiogenesis. Peptide E5 is applicable to relevant research on breast cancer.
CXCR   Apoptosis   Caspase   Akt   ERK  
Breast Cancer  
/
HY-N1088 Vindorosine
Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-114346A BODIPY FL EDA free base
ODIPY FL EDA free base is an amine-based, green fluorescent probe. The R-NH2 of ODIPY FL EDA free base can be coupled with aldehydes or ketones to form reversible Schiff base products. Convert to stable amine derivatives using reducing agents such as sodium borohydride or sodium cyanoborohydride. ODIPY FL EDA free base can be used to detect modified or normal deoxynucleotides and demonstrate DNA damage and genomic DNA methylation.
Fluorescent Dye  
/
HY-182094C DSPE-PEG5000-KTP
DSPE-PEG5000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG5000-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
Liposome  
Metabolic or Endocrine Disease  
/
HY-P2687 Ularitide
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
Natriuretic Peptide Receptor (NPR)  
Blood or Cardio-cerebrovascular Disease  
/
HY-182094 DSPE-PEG1000-KTP
DSPE-PEG1000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG1000-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
Liposome  
Metabolic or Endocrine Disease  
/
HY-135146G GSK-3484862 (GMP)
GSK-3484862 GMP is GSK-3484862 (HY-135146) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. GSK-3484862 is a highly potent non-covalent inhibitor and demethylating agent of DNMT1. GSK-3484862 induces genome-wide DNA demethylation, including the regulatory elements of DNMT3B and the promoter region of TERT, and significantly inhibits cell viability, growth, proliferation and self-renewal. GSK-3484862 blocks the transformation of young AT2 cells, induces apoptosis, and generates transcriptomic features similar to those of senescent cells. GSK-3484862 is widely used in studies related to lung cancer, oral squamous cell carcinoma and lung adenocarcinoma.
DNA Methyltransferase   Apoptosis  
/
HY-P10563 Noraramtide
Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma.
CD38   IFNAR  
Leukemia/Lymphoma/Myeloma  
/
HY-180885S KRAS G12D-IN-35
KRAS G12D-IN-35 (example 7) is a potent and orally active KRAS G12D inhibitor. KRAS G12D-IN-35 suppresses p-ERK in AGS cells and potently inhibits the proliferation of various KRAS G12D-mutant cancer cell lines. KRAS G12D-IN-35 inhibits tumor growth in HPAC and GP2D mouse models. KRAS G12D-IN-35 can be used for cancer research, such as pancreatic and colorectal cancer.
Ras   ERK  
Colorectal Cancer   Pancreatic Cancer  
/
HY-120521 Urodilatin
Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc.
Natriuretic Peptide Receptor (NPR)  
Neurological, Eye or Ear Disease  
/
HY-108864 Epoetin alfa
Epoetin alfa (Epogen) is a recombinant human erythropoietin whose amino acid sequence and biological activity are identical to those of endogenous erythropoietin (EPO). Epoetin alfa is a direct agonist of the EPO receptor (EPOR) on the surface of erythroid progenitor cells, and promotes the production and maturation of red blood cells. Epoetin alfa can be used for research on myelodysplastic syndrome-related anemia and hematological malignancies.
Transmembrane Glycoprotein  
Leukemia/Lymphoma/Myeloma  
/
HY-B0114S2 Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects.
Sodium Channel   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-Y0308D Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339
Sodium phosphate dibasic (Disodium hydrogen phosphate), meets analytical specification of Ph. Eur. BP USP FCC E339 is an inorganic dibasic phosphate that functions as an electrolyte supplement, a buffer carrier for injectable drugs, while also exhibiting nephrotoxicity. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 induces extensive nephrotic syndrome-like changes, including systemic symptoms such as persistent proteinuria, lipemia, hypercholesterolemia, and anemia, and causes severe renal pathological alterations such as renal enlargement, glomerular calcification, podocyte injury, and tubulointerstitial lesions. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 has the ability to induce phosphate-induced nephropathy and glomerular calcification, and can be widely used in studies on nephrotic syndrome and related renal pathological mechanisms.
Biochemical Assay Reagents  
Renal Disease  
/
HY-B1941R 4-tert-Octylphenol (Standard)
4-tert-Octylphenol (Standard) is the analytical standard of 4-tert-Octylphenol. This product is intended for research and analytical applications. 4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology.
Reference Standards   Endogenous Metabolite   Apoptosis   DNA/RNA Synthesis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P2193A TAT-amide TFA
TAT-amide TFA is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells.
Others  
Infection  
/
HY-B1319S1 Pramocaine-d9 hydrochloride
Pramocaine-d9 (Pramoxine-d9) hydrochloride is the d9-labeled Pramocaine hydrochloride (HY-B1319). Pramocaine hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.
Isotope-Labeled Compounds   Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-P10828 MAPI
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection.
Virus Protease  
Infection   Inflammation or Immune System Disease  
/
HY-149773S HPK1-IN-40-d2
HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity.
MAP4K  
Cancer   Inflammation or Immune System Disease  
/
HY-121532 (-)-Rasfonin
(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line).

Source: Talaromyces sp. 3656-A1

Ras   Apoptosis   Autophagy  
/
HY-10966G SB-590885 (GMP)
SB-590885 GMP is SB-590885 (HY-10966) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer.
Raf   Apoptosis  
Colorectal Cancer   Blood Disease  
/
HY-D3196 AG2
AG2 is a glucose uptake tracer and two-photon fluorescent probe. AG2 is taken up by cells via glucose-specific transport systems, rather than passive diffusion; it preferentially accumulates in cancer cells and colon cancer tissues compared with normal cells and tissues; it mainly localizes to mitochondria, with a small amount also distributed in the cytoplasm and cell membrane. AG2 can be used for colon cancer research.
Fluorescent Dye  
Cancer  
/
HY-182094A DSPE-PEG2000-KTP
DSPE-PEG2000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG2000-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
Liposome  
Metabolic or Endocrine Disease  
/
HY-133168R Englerin A (Standard)
Englerin A (Standard) is the analytical standard of Englerin A. This product is intended for research and analytical applications. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.
Reference Standards   TRP Channel  
/
HY-P991800 Anti-Mouse Dendritic Cells Antibody (33D1)
Anti-Mouse Dendritic Cells Antibody (33D1) reacts with the mouse dendritic cells. Dendritic cells (DC) are a small subpopulation of lymphoid cells with distinctive cytologic features, surface properties, and functions. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).

Species: Mouse

Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-13642G RG108 (GMP)
RG108 (GMP) is RG108 (HY-13642) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC50=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.
DNA Methyltransferase  
Cancer  
/
HY-182094B DSPE-PEG3400-KTP
DSPE-PEG3400-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG3400-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
Liposome  
Metabolic or Endocrine Disease  
/
HY-P5978 Atriopeptin III (rat)
Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure.
Natriuretic Peptide Receptor (NPR)  
Blood or Cardio-cerebrovascular Disease  
/
HY-16561G Resveratrol (GMP)
Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
DNA/RNA Synthesis   IKK   Autophagy   Mitophagy   Sirtuin   Apoptosis   Bacterial   Fungal   Keap1-Nrf2  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-113352S 7-Methylguanine-d3
7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.
Endogenous Metabolite  
/
HY-D3431 CFSE-Tz
CFSE-Tz is a fluorescent bioorthogonal probe constructed based on the IEDDA reaction, which is mainly used for visual tracing of amino acid uptake in living cells. The tetrazine group within the CFSE-Tz molecule quenches CFSE fluorescence via photoinduced electron transfer; after the probe specifically undergoes a bioorthogonal reaction with trans-cyclooctene-modified amino acids, the quenching effect is eliminated, and a green fluorescent signal is released, thereby dynamically monitoring the intracellular amino acid uptake process. CFSE-Tz can be applied to in vitro single-cell fluorescence imaging and studies related to amino acid metabolism in tumor cells (Ex = 495 nm, Em = 519 nm)[1][2].
Fluorescent Dye  
Cancer  
/
HY-D3179 CDg13
CDg13 is a fluorescent probe that specifically detects living neural stem/progenitor cells. CDg13 localizes to the endoplasmic reticulum via its dihexyl moiety, with no interaction with endoplasmic reticulum biomolecules. CDg13 undergoes selective efflux by active ABCG2 transporters, with increased intracellular accumulation following ABCG2 inhibition or knockdown. CDg13 isolates and enriches self-renewable neural stem/progenitor cells from embryonic mouse brain tissue, stains neural stem/progenitor cells brightly, and sorts ABCG2low cell populations from heterogeneous populations. (Ex/Em = 520/553 nm)
Fluorescent Dye   BCRP  
Neurological, Eye or Ear Disease  
/
HY-D3172 BD-105
BD-105 (Glucagon Yellow) is a glucagon-binding fluorescent probe with a KD value of 13.3 μM. BD-105 exhibits changes in fluorescence intensity upon interaction with glucagon, and colocalizes with glucagon in cells and tissues. BD-105 is a selective cell stain that labels glucagon-secreting cells without staining insulin-secreting cells or non-endocrine control cells. BD-105 serves as an imaging reagent for glucagon in live cells and tissues (Ex/Em = 540 nm/580 nm).
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-B0534S1 Moclobemide-d4
Moclobemide-d4 is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
Monoamine Oxidase  
Neurological, Eye or Ear Disease  
/
HY-B0534S Moclobemide-d8
Moclobemide-d8 (Ro111163-d8) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
Isotope-Labeled Compounds   Monoamine Oxidase  
Neurological, Eye or Ear Disease  
/
HY-139938S (±)11(12)-EET methyl ester-d11
(±)11(12)-EET-d11 methyl ester (11,12-EET methyl ester-d11) is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P11452 (KKEEE)3K
(KKEEE)3K is a kidney-targeting peptide. (KKEEE)3K enters renal tubular cells via megalin receptor-mediated endocytosis. (KKEEE)3K can be used in the research of renal drug delivery.
LDLR  
Renal Disease  
/
HY-W018555R D-Cysteine (Standard)
D-Cysteine (Standard) is the analytical standard of D-Cysteine. This product is intended for research and analytical applications. D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day[1][2][3][4].
Reference Standards   Endogenous Metabolite   Bacterial  
Neurological, Eye or Ear Disease   Bacterial Infection  
/
HY-50896S1 Erlotinib-13C6
Erlotinib-13C6 (CP-358774-13C6) is the 13C-labeled Erlotinib (HY-50896). Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, fibronectin, α-SMA, collagen deposition, and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, pancreatic cancer, renal fibrosis, and other conditions.
Isotope-Labeled Compounds   EGFR   OAT   ERK   GSK-3   β-catenin  
Gastric Cancer   Pancreatic Cancer   Renal Disease   Non-Small Cell Lung Cancer   Lung Adenocarcinoma  
/
HY-N12921 (E)-8-Dodecenol
(E)-8-Dodecenol is a pheromone that increases the frequency of electro-pulse spikes in mid-receptor neurons of codling moth (Cydia pomonella L.). (E)-8-Dodecenol is isolated from female codling moths.

Source: Cydia pomonella

Sex Pheromone  
Metabolic or Endocrine Disease  
/
HY-12273G DMH-1 (GMP)
DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 (GMP) is a selective BMP inhibitor. DMH-1 (GMP) upregulates the expression of SOX1. DMH-1 (GMP) increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 (GMP) induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons.
Organoid   TGF-β Receptor   Microtubule/Tubulin  
Neurological, Eye or Ear Disease   Heart Disease  
/
HY-D2972 Apotracker Red
Apotracker Red is a fluorogenic peptide (excitation/emission: 561/610 nm). Apotracker Red binds to PtdSer on the surface of cells. Apotracker Red rapidly and selectively stains Apoptotic cells but not viable cells. Apotracker Red can be used to detect cancer cell death in real time.
Fluorescent Dye   Apoptosis   Tim3  
Cancer  
/
HY-179551S (±)11(12)-EET-d11 Methyl ester
(±)11(12)-EET-d11 Methyl ester is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis.
Isotope-Labeled Compounds  
/
HY-D1562 CytoTrace Red CMTPX
CytoTrace Red CMTPX is a cell permeable long-term cell tracer (Ex=577 nm, Em=602 nm).
Fluorescent Dye  
/
HY-W653970 5-Azacytidine-15N4
5-Azacytidine-15N4 is 13C and 15N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
Isotope-Labeled Compounds   Organoid   Bacterial   DNA Methyltransferase   Nucleoside Antimetabolite/Analog   Antibiotic   Autophagy  
Infection  
/
HY-N14774 Lactoquinomycin B
Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively.
Antibiotic   Bacterial  
Infection  
/
HY-122940R Precocene II (Standard)
Precocene II (Standard) is the analytical standard of Precocene II (HY-122940). This product is intended for research and analytical applications. Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity.
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-13599S2 Cladribine-15N
Cladribine-15N (2-Chloro-2′-deoxyadenosine-15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds   Adenosine Deaminase   Apoptosis  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-W002438R 6-Hydroxyindole (Standard)
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole (HY-W002438). This product is intended for research and analytical applications. 6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases.
Reference Standards   Biochemical Assay Reagents   Endogenous Metabolite   OAT   Ferroptosis  
Neurological, Eye or Ear Disease   Renal Failure  
/
HY-P2225 SQ 20858
SQ 20858 is a competitive Angiotensin-converting enzyme inhibitor. SQ 20858 blocks the conversion of Angiotensin I to Angiotensin II, inhibits the inactivation of Bradykinin (HY-P0206) and amplifies the hypotensive response of Bradykinin. SQ 20858 blocks the pressor responses of Angiotensin I and rabbit Renin, but has no effect on the pressor effect of angiotensin II . SQ 20858 reduces blood pressure in renal hypertension models. SQ 20858 can be used in studies related to chronic renal hypertension.
Angiotensin-converting Enzyme (ACE)  
Renal Disease   Hypertension  
/
HY-13599S Cladribine-d4
Cladribine-d4 (2-Chloro-2′-deoxyadenosine-d4) is deuterium labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-129283 Goralatide
Goralatide is a compound that regulates the thermal sensitivity of hematopoietic progenitor cells. It can reduce the thermal sensitivity of normal hematopoietic progenitor cells and increase the difference in thermal sensitivity between leukemia progenitor cells and normal progenitor cells, thereby increasing the inhibition window of hyperthermia therapy.
Ras  
/
HY-W018324S 5-Hydroxymethylcytosine-13C,d2
5-Hydroxymethylcytosine-13C,d2 is the 13C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes).
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-13599S1 Cladribine-13C5,15N2
Cladribine-13C5,15N2 (2-Chloro-2′-deoxyadenosine-13C5,15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-D3304 Cholyl-L-lysine fluorescein disodium
Cholyl-L-lysine fluorescein disodium is a Fluorescent substrate. Cholyl-L-lysine fluorescein disodium can be used in organoid research.
Fluorescent Dye  
/
HY-10475G AM580 (GMP)
AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist.
RAR/RXR  
Cancer  
/
HY-P99913 Eflapegrastim
Eflapegrastim is a composite protein consisting of a genetically modified granulocyte-colony stimulating factor (GCSF) molecule linked via a chemical bond to an IgG4 Fc fragment (LAPS-carrier). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia.

Species: Human

c-Fms  
Inflammation or Immune System Disease   Breast Cancer  
/
HY-129283A Goralatide TFA
Goralatide TFA is an inhibitor of cell cycle progression. Goralatide TFA enhances selectivity of hyperthermic purging of human progenitor cells. Goralatide TFA has the potential for the research of leukemia.
Others  
Cancer  
/
HY-12008S Erlotinib-d6 hydrochloride
Erlotinib-d6 hydrochloride (CP-358774-d6 hydrochloride) is the deuterated-labeled Erlotinib Hydrochloride (HY-12008). Erlotinib (CP-358774) Hydrochloride is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib Hydrochloride also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib Hydrochloride blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib Hydrochloride inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, as well as the deposition of fibronectin, α-SMA, collagen and renal injury markers. Erlotinib Hydrochloride is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib Hydrochloride can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, EGFR inhibitor resistance and renal fibrosis.
Isotope-Labeled Compounds   EGFR   OAT   ERK   GSK-3   β-catenin  
Gastric Cancer   Pancreatic Cancer   Renal Disease   Non-Small Cell Lung Cancer   Lung Adenocarcinoma  
/
HY-P991999 OM-RCA-01
OM-RCA-01 is an anti-FGFR1 monoclonal antibody with a Kd of 1.59 nM for human FGFR1. OM-RCA-01 inhibits the phosphorylation of FGFR1, blocks FGF-mediated signaling pathways, and suppresses the proliferation of downstream tumor cells. OM-RCA-01 delays tumor growth in lung cancer and renal cancer xenograft models expressing FGFR1. When combined with Nivolumab, OM-RCA-01 enhances the release of IFN-γ and IL-2. OM-RCA-01 is applicable for the research of lung cancer and renal cell carcinoma.

Species: Human

FGFR   IFNAR   Interleukin Related  
Lung Cancer   Renal Cancer  
/
HY-P992101 Aritinercept
Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus.

Species: Human

TNF Receptor   IFNAR   Interleukin Related  
Systemic Lupus Erythematosus  
/
HY-N0739R Betaine chloride (Standard)
Betaine (chloride) (Standard) is the analytical standard of Betaine (chloride). This product is intended for research and analytical applications. Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.
Reference Standards   Endogenous Metabolite  
/
HY-P3066 SKF 100398
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP.
Vasopressin Receptor  
Metabolic or Endocrine Disease  
/
HY-30099 O,O,S-Trimethyl ester phosphorothioic acid
O,O,S-Trimethyl ester phosphorothioic acid is a chemical substance with biological activity for studying renal fibrosis. O,O,S-Trimethyl ester phosphorothioic acid can be used as an experimental model for studying renal fibrosis.
Biochemical Assay Reagents  
/
HY-P1104 FC131
FC131 is a CXCR4 antagonist that inhibits AKT kinase activity in AML OCI-AML3 cells. D-ArgFC131, a derivative of FC131, inhibits the phosphorylation of downstream ERK1/2 and Akt, induces caspase-3 pathway-mediated apoptosis, and causes cell cycle arrest. FC131 exerts cytotoxic effects in cancer cells such as AML cells. FC131 is applicable for cancer-related research.
CXCR   Akt   Apoptosis  
Leukemia/Lymphoma/Myeloma  
/
HY-NP070 Lotus tetragonolobus lectin
Lotus tetragonolobus lectin (LTL) is a plant lectin that specifically recognizes and binds to α-L-fucopyranosyl residues, a sugar structure serving as the key terminal glycosyl group of human blood type O antigen (H antigen). Lotus tetragonolobus lectin exerts macrophage migration inhibitory activity in monomeric form. Lotus tetragonolobus lectin labels and identifies renal proximal tubular epithelial cells to evaluate histopathological changes of sepsis-induced acute kidney injury. Lotus tetragonolobus lectin is applicable to studies in glycobiology, immunology and renal pathology.
/
HY-P991881 KY1070
KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease .

Species: Human

TGF-β Receptor   Hepcidin   Ferroportin  
Blood Disease  
/
HY-A0248AS Polymyxin B1-d7 TFA
Polymyxin B1-d7 TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.

Source: Bacilus polymyxa

Isotope-Labeled Compounds   Bacterial  
/
HY-P99035 Naptumomab
Naptumomab is a fusion protein of a tumor-targeting superantigen (TTS). Naptumomab stimulates the immune system to recognize and kill tumor cells and can be used in the study of refractory solid tumors such as renal cell carcinoma.

Species: Human

Others  
Inflammation or Immune System Disease   Non-Small Cell Lung Cancer   Luminal Breast Cancer   Triple-Negative Breast Cancer  
/
HY-50896S Erlotinib-d6
Erlotinib-d6 (CP-358774-d6) is the deuterated-labeled Erlotinib (HY-50896). Erlotinib (CP-358774) is a selective, orally active EGFR tyrosine kinase inhibitor. Erlotinib also acts as a substrate and inhibitor of OATP2B1, with an IC50 of approximately 0.079 μM for inhibiting OATP2B1-mediated uptake of estrone 3-sulfate. Erlotinib blocks EGFR phosphorylation, downstream signal transduction, as well as the growth and proliferation of cancer cells. Erlotinib inhibits MMP-10-mediated renal injury, fibrotic lesions, the ERK1/2, GSK-3β and β-catenin signaling pathways, fibronectin, α-SMA, collagen deposition, and renal injury markers. Erlotinib is metabolized via CYP3A to produce the active metabolite OSI-420. Erlotinib can be used in research related to non-small cell lung cancer, gastric cancer, papillary renal cell carcinoma, pancreatic cancer, renal fibrosis, and other conditions.
Isotope-Labeled Compounds   EGFR   OAT   ERK   GSK-3   β-catenin  
Gastric Cancer   Pancreatic Cancer   Renal Disease   Non-Small Cell Lung Cancer   Lung Adenocarcinoma  
/
HY-W008864 Lactose octaacetate
Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1.
Fungal  
Bacterial Infection   Fungal Infection  
/
HY-169675 Lacripep
Lacripep is a synthetic tear protein. Lacripep binds to and activates syndecan-1 (SDC1). Lacripep restores progenitor cell identity and epithelial barrier function. Lacripep resolves dry eye.
Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P991208 Flt-3L-Ig (hum/hum)
Flt-3L-Ig (hum/hum) (hFlt3L) is a Flt3 ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of IL-2, CCL2 and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation.

Species: Human

FLT3   Interleukin Related   CCR  
Psoriasis  
/
HY-W740027 5-Methyl-2'-deoxycytidine-d3
5-Methyl-2'-deoxycytidine-d3 (5-Methyldeoxycytidine-d3) is the deuterium labeled Methyl-2'-deoxycytidine (HY-W012078). 5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells.
Isotope-Labeled Compounds   Endogenous Metabolite   DNA Methyltransferase  
/
HY-P10143 MMP-2/MMP-9 Substrate
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties.
MMP  
/
HY-113465S Leukotriene E4-d5
Leukotriene E4-d5 (LTE4-d5) is the d-5-labeled Leukotriene E4 (HY-113465). Leukotriene E4 is a stable final metabolite of cysteinyl leukotrienes, produced by immune cells such as mast cells and eosinophils. Leukotriene E4 serves as a key biomarker for evaluating asthma severity, Aspirin (HY-14654) sensitivity, and mast cell activation disorders. Leukotriene E4 is a full functional agonist of CysLT1R, which induces sustained intracellular calcium mobilization and Erk phosphorylation. Leukotriene E4 mediates inflammation in a P2Y12 receptor-dependent manner. Leukotriene E4 can be used in the research of asthma and non-steroidal anti-inflammatory drug-exacerbated respiratory diseases.
Isotope-Labeled Compounds   Endogenous Metabolite   Leukotriene Receptor   Calcium Channel   ERK   P2Y Receptor  
Asthma  
/
HY-P991795 Anti-Mouse/Human CXCL12 Antibody (K15C)
Anti-Mouse/Human CXCL12 Antibody (K15C) is an antibody targeting SDF-1/CXCL12. Anti-Mouse/Human CXCL12 Antibody (K15C) blocks the biological activity of SDF-1 secreted by cancer-associated fibroblasts. Anti-Mouse/Human CXCL12 Antibody (K15C) inhibits tumor growth, reduces tumor microvessel density, and decreases the proportion of Sca1+CD31+ endothelial progenitor cells in tumors. Anti-Mouse/Human CXCL12 Antibody (K15C) can be used for research on aggressive human breast cancer. The recommended isotype control is Mouse IgG2a kappa, Isotype Control (HY-P99978).

Species: Mouse/Human

CXCR  
Breast Cancer  
/
HY-42682R D(+)-Galactosamine hydrochloride (Standard)
D(+)-Galactosamine (hydrochloride) (Standard) is the analytical standard of D(+)-Galactosamine (hydrochloride). This product is intended for research and analytical applications. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
Reference Standards  
Inflammation or Immune System Disease  
/
HY-P991911 PLT012
PLT012 is a humanized IgG4 antibody targeting CD36. PLT012 inhibits the lipid-binding domain of CD36. PLT012 blocks CD36-mediated metabolic adaptation in regulatory T cells (Tregs) and CD8+ tumor-infiltrating lymphocytes (TILs), thereby inhibiting tumor growth and shifting the tumor microenvironment from immunosuppressive to immunosupportive. PLT012 reduces intratumoral Tregs, enhances CD8+ T cell infiltration and cytotoxic function, and increases the abundance of progenitor-exhausted T cells. PLT012 exerts robust antitumor activity and synergizes with anti-PD-L1 or standard-of-care regimens (anti-VEGF + anti-PD-L1). PLT012 can be used for hepatocellular carcinoma, colorectal cancer and solid tumor research.

Species: Human

Scavenger Receptor Class B type I (SR-BI）  
Colorectal Cancer   Hepatitis B Virus Related Hepatocellular Carcinoma  
/
HY-P990002 Anti-Mouse CD117/c-Kit Antibody (2B8)
Anti-Mouse CD117/c-Kit Antibody (2B8) is an IgG2b antibody, targeting to mouse CD117/c-Kit. Anti-Mouse CD117/c-Kit Antibody (2B8) reacts with mouse c-Kit (also known as CD117), which is expressed on hematopoietic progenitor cells, mast cells, and acute myeloid leukemia (AML) cells. Anti-Mouse CD117/c-Kit Antibody (2B8) can be used for the detection of flow cytometry, immunofluorescence and immunohistochemistry in cancer and inflammation.

Species: Mouse

c-Kit  
Cancer   Inflammation or Immune System Disease  
/
HY-NP0135 Lotus Tetragonolobus Lectin (Fluorescein)
Lotus Tetragonolobus Lectin (Fluorescein) (LTL (Fluorescein)) is a fluorescein-labeled plant lectin extracted from Lotus tetragonolobus, which binds to specific carbohydrate ligands. Lotus Tetragonolobus Lectin (Fluorescein) serves as a marker for proximal tubules. Lotus Tetragonolobus Lectin (Fluorescein) staining identifies renal proximal tubules. Lotus Tetragonolobus Lectin (Fluorescein) can be used in studies related to glomerulocystic kidney disease.
Fluorescent Dye  
Urogenital Disease  
/
HY-P2254 H3K27(Me3) (15-34)
H3K27(Me3) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me).
Histone Methyltransferase  
Cancer  
/
HY-W022880 4-Bromo-6-fluoro-1H-indazole
4-Bromo-6-fluoro-1H-indazole is a drug synthesis intermediate that can be used to synthesize an inhibitor of hematopoietic progenitor kinase 1 (hpk1).
Drug Intermediate  
/
HY-P99287 Elsilimomab
Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a KD of 22 pM and an IC50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA).

Species: Human

Interleukin Related  
Cancer   Inflammation or Immune System Disease  
/
HY-W008091S 5-Methylcytosine-d4
5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine (HY-W008091). 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma.
DNA/RNA Synthesis   Endogenous Metabolite   Isotope-Labeled Compounds  
/
HY-B0710S Betaine-13C3
Betaine-13C3 (Trimethylglycine-13C3) is the 13C labeled isotope of Betaine (HY-B0710). Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity.
Isotope-Labeled Compounds  
Metabolic or Endocrine Disease  
/
HY-P10369 Betiatide
Betiatide, as a chelating agent for Technetium-99m (99mTc), is used to prepare 99mTc-MAG3 (mercaptoacetyltriglycine), a radiopharmaceutical for renal function imaging. Betiatide is used for the diagnosis of congenital and acquired abnormalities, renal failure, urinary tract obstructions, and calculi. Betiatide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
Biochemical Assay Reagents   Radionuclide-Drug Conjugates (RDCs)  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-76585 Paricalcitol-d6
Paricalcitol-d6 is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
VD/VDR  
Metabolic or Endocrine Disease  
/
HY-171544 AGS-16C3F
AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC).
Antibody-Drug Conjugates (ADCs)   Phosphodiesterase (PDE)  
/
HY-P991526 M701
M701 is a T-cell engager bispecific humanized antibody targeting epithelial cell adhesion molecule (EpCAM) and cluster of differentiation 3 (CD3). M701 binds to EpCAM on tumor cells and CD3 on T cells, thereby linking the two cell populations to achieve targeted cytotoxicity and T cell-mediated cytotoxicity. M701 is applicable to research related to advanced epithelial solid tumors.

Species: Human

CD3  
Cancer  
/
HY-D1603 BODIPY FL-EDA
BODIPY FL-EDA is a widely used fluorescent dye for quantitative analysis of nucleotides. BODIPY FL-EDA is an aliphatic amine analog that can react with aldehydes and ketones. BODIPY FL-EDA can be used to detect both modified and unmodified deoxynucleotides and to determine DNA damage and genomic DNA methylation through capillary electrophoresis with laser-induced fluorescence (CE-LIF). Additionally, it can be used for quantifying intracellular ATP levels. The excitation wavelength is 500 nm, and the emission wavelength is 510 nm.
Fluorescent Dye  
/
HY-W018324 5-Hydroxymethylcytosine
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes).
Endogenous Metabolite  
Metabolic or Endocrine Disease   Lung Cancer   Leukemia/Lymphoma/Myeloma   Alzheimer's Disease   Parkinson's Disease  
/
HY-122940 Precocene II
Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of juvenile hormone. Precocene II inhibits corpora allata function and downregulates juvenile hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity.

Source: Insects

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-B0504S1 Creatinine-13C
Creatinine-13C is the 13C-labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Metabolic or Endocrine Disease  
/
HY-W002438 6-Hydroxyindole
6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases.
Biochemical Assay Reagents   Endogenous Metabolite   OAT   Ferroptosis  
Neurological, Eye or Ear Disease   Renal Failure  
/
HY-15001G Stemregenin 1 (GMP)
Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC50 of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases.
Aryl Hydrocarbon Receptor  
Cancer  
/
HY-P2193 TAT-amide
TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells.
Others  
Infection  
/
HY-P991155 Ramantamig
Ramantamig (JNJ-79635322) is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (BCMA). Ramantamig binds to BCMA and GPRC5D on multiple myeloma cells, binds to CD3ε on T cells, forms immunological synapses, and enables T-cell-mediated cytotoxicity. Ramantamig activates T cells concomitantly with inducing myeloma cell cytotoxicity, with no nonspecific T-cell activation in the absence of target myeloma cells. Ramantamig carries mutations to reduce interaction with Fc receptors and disrupt protein A binding of monomeric and homodimerized chains. Ramantamig can be used for the research of multiple myeloma.

Species: Human

CD3   TNF Receptor  
Multiple Myeloma  
/
HY-B0710R Betaine (Standard)
Betaine (Standard) is the analytical standard of Betaine. This product is intended for research and analytical applications. Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity.
Endogenous Metabolite   Reference Standards  
Metabolic or Endocrine Disease  
/
HY-P99161 Tilvestamab
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas.

Species: Human

TAM Receptor  
Cancer  
/
HY-113427A cis-Vaccenic acid
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate, acts a potential fetal hemoglobin inducer.

Source: Rhodopseudomonas capsulate

Antibiotic  
Cancer  
/
HY-P1104A FC131 TFA
FC131 TFA is a CXCR4 antagonist that inhibits AKT kinase activity in AML OCI-AML3 cells. D-ArgFC131, a derivative of FC131 TFA, inhibits the phosphorylation of downstream ERK1/2 and Akt, induces caspase-3 pathway-mediated apoptosis, and causes cell cycle arrest. FC131 TFA exerts cytotoxic effects in cancer cells such as AML cells. FC131 TFA is applicable for cancer-related research.
CXCR   Akt   Apoptosis  
Leukemia/Lymphoma/Myeloma  
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HY-P99273 Vorsetuzumab
Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma.

Species: Human

TNF Receptor  
Cancer  
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HY-131131 5-CFDA-AM
5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein, which contains an additional negative charge and can be better retained in the cell. 5-CFDA-AM can be used to detect cell viability.
Fluorescent Dye  
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HY-W583212 Zn(II) Mesoporphyrin IX
Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention.
Biochemical Assay Reagents   Heme Oxygenase (HO)  
Inflammation or Immune System Disease  
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HY-N3540 Caraphenol A
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively.
Others  
Inflammation or Immune System Disease  
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HY-P990045 Lixudebart
Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis.

Species: Human

Claudin  
Renal Disease  
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HY-B0504S2 Creatinine-d5
Creatinine-d5 is the deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   GABA Receptor  
Metabolic or Endocrine Disease  
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HY-W018555 D-Cysteine
D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day.
Endogenous Metabolite   Bacterial  
Neurological, Eye or Ear Disease   Bacterial Infection  
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HY-P990608 Alpitatug
Alpitatug (IMC 3C5) is a fully human monoclonal antibody and also a VEGFR3 inhibitor. Alpitatug blocks renal lymphangiogenesis, prevents the formation of tubulointerstitial lymphatic vessels, and reduces the number of lymphatic vessels in rats. Alpitatug does not alter the proteinuria level, inflammatory cell infiltration, fibrosis markers or renal function parameters in proteinuric rats. Alpitatug can be used in research related to proteinuric nephropathy and advanced solid tumors.

Species: Human

CD3  
Cancer   Renal Disease  
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HY-P10272 Rusfertide
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis.
Ferroportin  
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HY-108852 Basiliximab
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation.

Species: Human

Interleukin Related  
Acute Myeloid Leukemia   Acute Lymphoblastic Leukemia   Non-Hodgkin Lymphoma   Glioblastoma   Astrocytoma   SARS-CoV-2 Infection   Amyotrophic Lateral Sclerosis   Chronic Obstructive Pulmonary Disease   Ulcerative Colitis  
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HY-134124 Glutathione ethyl ester
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense.
Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
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HY-P70534 TREM-2 Protein, Human (HEK293, His)
TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2 Protein, Human (HEK293, His) is the recombinant human-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P71381 TREM-2 Protein, Mouse (HEK293, His)
TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

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HY-P71052 Renin Protein, Human (HEK293, His)
Renin, a specialized endopeptidase, uniquely converts angiotensinogen to angiotensin I, initiating a cascade that elevates blood pressure and enhances kidney sodium retention. Renin's precision in initiating the angiotensin pathway underscores its pivotal role in regulating blood pressure and electrolyte balance. Renin Protein, Human (HEK293, His) is the recombinant human-derived Renin protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins G-Protein-Coupled Receptors (GPCRs) Protease-activated Receptor

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HY-P70003 DPEP1 Protein, Human (HEK293, His)
Dipeptidase 1 (DPEP1) has multiple enzymatic functions and can hydrolyze various dipeptides, including the conversion of leukotriene D4 to leukotriene E4. It is also involved in the degradation of cysteinylbisglycine resulting from the breakdown of glutathione. DPEP1 Protein, Human (HEK293, His) is the recombinant human-derived DPEP1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P70390 Lysozyme C/LYZ Protein, Human (HEK293, His)
Lysozyme C, a bacteriolytic enzyme within the lysozyme family, closely associates with the monocyte-macrophage system, enhancing immune agent activity in tissues and body fluids. Lysozyme C/LYZ Protein, Human (HEK293, His) is the recombinant human-derived Lysozyme C/LYZ protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P71081 Renin Protein, Mouse (HEK293, His)
Renin Protein, a highly specific endopeptidase, generates angiotensin I from angiotensinogen, initiating a cascade that elevates blood pressure and enhances kidney sodium retention.Renin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Renin protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins G-Protein-Coupled Receptors (GPCRs) Protease-activated Receptor

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HY-P7737 Carboxypeptidase M/CPM Protein, Human (HEK293, His)
Carboxypeptidase M Protein, Human (HEK293, His) is an approximately 55.0 kDa Carboxypeptidase M protein with a His-flag. Carboxypeptidase M is a membrane-bound arginine/lysine carboxypeptidase enzyme belongs to the carboxypeptidases family.

Species: Human; Source: HEK293

Enzymes & Regulators Carboxypeptidase Carboxypeptidase M

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HY-P701224 BMI1 Protein, Human (His)
BMI1 Protein, a component of the Polycomb group PRC1-like complex, maintains transcriptional repression in genes, including Hox genes, by monoubiquitinating histone H2A. It regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. Interacts with various partners in the PRC1-like complex, such as RNF2, CBX2, CBX4, CBX8, PHC1, PHC2, PHC3, and UB2D3, forming complexes crucial for chromatin modification and gene expression control. BMI1 Protein, Human (E.coli,N-His) is the recombinant human-derived BMI1 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P73262 Kallikrein-1 Protein, Human (HEK293, His)
Kallikrein-1 protein cleaves bonds in kininogen to release Lys-bradykinin. It also cleaves Neisseria meningitidis NHBA in saliva during microbial infection. Kallikrein-1 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P70144 Kallikrein-1 Protein, Human (HEK293, His, solution)
Kallikrein-1 protein cleaves bonds in kininogen to release Lys-bradykinin. It also cleaves Neisseria meningitidis NHBA in saliva during microbial infection.Kallikrein-1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Kallikrein-1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P70390A Lysozyme C/LYZ Protein, Human (HEK293, C-His)
Lysozyme C, a bacteriolytic enzyme within the lysozyme family, closely associates with the monocyte-macrophage system, enhancing immune agent activity in tissues and body fluids. Lysozyme C/LYZ Protein, Human (HEK293, His) is the recombinant human-derived Lysozyme C/LYZ protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P72438 TREM-2 Protein, Cynomolgus (HEK293, His)
TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Cynomolgus; Source: HEK293

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HY-P701054 TREML1 Protein, Human (HEK293, hFc)
TREML1 is a trigger receptor 1 expressed on myeloid cells that activates myeloid cells via the adaptor protein DAP12. TREML1 promotes microglial phagocytosis of Aβ and is associated with the immune response to AD. TREML1 Protein, Human (HEK293, hFc) is the recombinant human-derived TREML1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P7614 ASXL1 Protein, Human (GST)
ASXL1 Protein, Human (GST) is a recombinant human Additional Sex Combs-like Protein 1 (ASXL1) expressed in E. coli with a GST tag. ASXLs make biological and functional roles in development, cancer, and transcription.

Species: Human; Source: E. coli

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HY-P704938 TREM-2 Protein, Human (HEK293, Fc)
TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2, Human (HEK293, Fc) is the recombinant human-derived TREM-2 protein, expressed by HEK293, with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P70302 Kallikrein-1 Protein, Mouse (HEK293, His)
Kallikrein-1 protein is a member of the glandular kallikrein family and plays a vital role in enzyme activity by cleaving the Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin..This proteolysis is critical for the production of bradykinin, a bioactive peptide involved in multiple physiological processes, including blood pressure regulation, inflammation, and vascular permeability.Kallikrein-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Kallikrein-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P74179 EED Protein, Human (sf9, His-GST)
EED protein is a core member of the Polycomb group (PcG) and is critical in the PRC2/EED-EZH2 complex, driving "Lys-9" and "Lys-27" methylation on histone H3 to achieve transcriptional repression . It recognizes trimethylated "Lys-26" on histone H1 and inhibits the methyltransferase activity of the PRC2 complex on nucleosomal histone H3 "Lys-27". EED Protein, Human (sf9, His-GST) is the recombinant human-derived EED protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P71382 TREML1 Protein, Human (HEK293, His)
TREML1 (triggering receptor expressed on myeloid cells, like 1) is a cell surface receptor that may play a role in innate and adaptive immune responses. When phosphorylated, TREML1 interacts with the proteins PTPN6 and PTPN11, suggesting that it may be involved in regulating signaling pathways related to immune processes. TREML1 Protein, Human (HEK293, His) is the recombinant human-derived TREML1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P72774 CD300LB Protein, Human (HEK293, hFc)
CD300LB Protein, an activating immune receptor, engages in immune modulation by interacting with the ITAM-bearing adapter TYROBP and recruiting GRB2 independently. The interaction with TYROBP enhances cell surface expression and activation properties. In the presence of FYN, CD300LB also interacts with GRB2, showcasing its multifaceted contribution to immune signaling pathways. CD300LB Protein, Human (HEK293, hFc) is the recombinant human-derived CD300LB protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

CD Antigens Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins CLM-7/CD300b

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HY-P7738 Carboxypeptidase M/CPM Protein, Mouse (HEK293, His)
Carboxypeptidase M/CPM Protein, Mouse (HEK293, His) is an approximately 56.0 kDa mouse carboxypeptidase M protein with a His-flag. Carboxypeptidase M/CPM is a membrane-bound arginine/lysine carboxypeptidase enzyme belongs to the carboxypeptidases family.

Species: Mouse; Source: HEK293

Enzymes & Regulators Carboxypeptidase Carboxypeptidase M

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HY-P700836 TREML1 Protein, Mouse (HEK293, hFc)
TREML1 is a trigger receptor 1 expressed on myeloid cells that activates myeloid cells via the adaptor protein DAP12. TREML1 promotes microglial phagocytosis of Aβ and is associated with the immune response to AD. TREML1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TREML1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins

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HY-P702971 NFATC1 Protein, Human (sf9, GST)
NFATC1 Protein, Human (sf9, GST) is the recombinant human-derived NFATC1, expressed by Sf9 insect cells , with GST labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators

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HY-P704937 TREM-2 Protein, Human (HEK293, mFc)
TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2, Human (HEK293, mFc) is the recombinant human-derived TREM-2 protein, expressed by HEK293, with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P81086 RAGE Antibody
RAGE Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to RAGE.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80275 PFKFB3 Antibody (YA232)
PFKFB3 Antibody (YA232) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PFKFB3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81086A RAGE Antibody(YA3549)
RAGE Antibody(YA3549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAGE.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86128 CD34 Antibody (YA5820)
CD34 Antibody (YA5820) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD34.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86451 Melan-A Antibody (YA6143)
Melan-A Antibody (YA6143) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Melan-A.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80353 SUZ12 Antibody (YA044)
SUZ12 Antibody (YA044) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUZ12.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81486 DPEP1/MDP Antibody (YA1231)
DPEP1/MDP Antibody (YA1231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPEP1/MDP.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85677 NFkB p65 Antibody (YA5369)
NFkB p65 Antibody (YA5369) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NFkB p65.

Host: Mouse; Reactivity: Human, Mouse,

Monoclonal Antibodies Primary Antibodies

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HY-P89689 EED Antibody (YA9033)
EED Antibody (YA9033) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EED.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Primary Antibodies

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HY-P810408 Syntaxin 4 Antibody (YA9723)
Syntaxin 4 Antibody (YA9723) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Syntaxin 4.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811230 PCGF6 Antibody
PCGF6 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PCGF6.

Host: Rabbit; Reactivity: Human, Mouse

Polyclonal Antibodies Primary Antibodies

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HY-P811113 PHF1 Antibody
PHF1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PHF1.

Host: Rabbit; Reactivity: Human, Bovine

Polyclonal Antibodies Primary Antibodies

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HY-P83295 Melan-A Antibody (YA3040)
Melan-A Antibody (YA3040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Melan-A.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83392 KCTD3 Antibody (YA3137)
KCTD3 Antibody (YA3137) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KCTD3.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83392A KCTD3 Antibody (YA3137)(PBS only)
KCTD3 Antibody (YA3137) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KCTD3.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83440 SUZ12 Antibody (YA3185)
SUZ12 Antibody (YA3185) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUZ12.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84238A CD34 Antibody (YA3935)(PBS only)
CD34 Antibody (YA3935) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD34.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P85302 NPT1 Antibody (YA4994)
NPT1 Antibody (YA4994) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NPT1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85378 SUZ12 Antibody (YA5070)
SUZ12 Antibody (YA5070) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SUZ12.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85699 NFAT5 Antibody (YA5391)
NFAT5 Antibody (YA5391) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NFAT5.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P85788 Lysozyme Antibody (YA5480)
Lysozyme Antibody (YA5480) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to Lysozyme.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P85918 Melan-A Antibody (YA5610)
Melan-A Antibody (YA5610) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Melan-A.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86022 Melan-A Antibody (YA5714)
Melan-A Antibody (YA5714) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Melan-A.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86269 KCTD3 Antibody (YA5961)
KCTD3 Antibody (YA5961) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KCTD3.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86583 SUZ12 Antibody (YA6275)
SUZ12 Antibody (YA6275) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUZ12.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85060 Bmi-1 Antibody (YA4752)
Bmi-1 Antibody (YA4752) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Bmi-1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86492 NF-κB p65 Antibody (YA6184)
NF-κB p65 Antibody (YA6184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB p65.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87926 Bmi-1 Antibody (YA7611)
Bmi-1 Antibody (YA7611) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Bmi-1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-K0305 Human CD34+ Cells Negative Selection Kit

MCE Human CD34+ Cells Negative Selection Kit is designed for the isolation of CD34+ cells from human cord blood mononuclear cells (CBMC) or human peripheral blood mononuclear cells (PBMC).

Cell Biology Cell Isolation

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HY-K0308 Mouse CD4+ Cell Positive Selection Kit

MCE Mouse CD4+ Cells Positive Selection Kit is designed for the isolation of CD4+ cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

Cell Biology Cell Isolation

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HY-K0309 Mouse CD8+ T Cells Negative Selection Kit

MCE Mouse CD8+ T Cells Negative Selection Kit is designed for the isolation of CD8+ T cells from single cell suspensions of mouse spleen cells and lymph nodes.

Cell Biology Cell Isolation

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HY-K0354 Mouse CD3/CD28 T Cell Activation Magnetic Beads

MCE Mouse CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

Cell Biology Cell Isolation

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HY-K0355 Mouse CD3 Cell Depletion Magnetic Beads (Positive Selection)

MCE Mouse CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-mouse CD3 antibodies, enabling the specific binding and magnetic removal of CD3+ cells from single-cell suspensions derived from mouse spleen and other tissues. This allows efficient enrichment of the non-CD3+ cell population.

Cell Biology Cell Isolation

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HY-K0356 Human CD3 Cell Depletion Magnetic Beads (Positive Selection)

MCE Human CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-human CD3 antibodies, enabling the specific binding and magnetic removal of CD3+ cells from single-cell suspensions derived from human peripheral blood mononuclear cells (PBMCs) or human peripheral blood leukocytes (WBCs). This allows efficient enrichment of the non-CD3+ cell population.

Cell Biology Cell Isolation

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HY-K0357 Mouse Mature B Cell Negative Selection Kit

MCE Mouse Mature B Cell Negative Selection Kit enables the efficient isolation of mature B cells from single-cell suspensions prepared from mouse spleen, lymph nodes, or bone marrow. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells (non-B cells), followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of mouse mature B cells.

Cell Biology Cell Isolation

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HY-K0358 Human CD66b+ Cell Positive Selection Kit

MCE Human CD66b+ Cell Positive Selection Kit is designed for the efficient isolation of CD66b+ cells from human peripheral blood single-cell suspensions. CD66b+ cells are first specifically labeled with the CD66b Capture Antibody and subsequently captured using Releasable Magnetic Beads. Following magnetic separation, the beads are detached from the cell surface using Magnetic Beads Release Buffer, resulting in highly purified CD66b+ cells free of residual magnetic bead labeling.

Cell Biology Cell Isolation

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HY-K0360 Mouse CD4+ CD25+ Regulatory T Cell Positive Selection Kit

MCE Mouse CD4+ CD25+ Regulatory T Cell Positive Selection Kit is designed for the isolation of CD4+ CD25+ regulatory T cells (Tregs) from mouse splenic single-cell suspensions. The kit utilizes a two-step isolation strategy. First, CD4 Enrichment Beads are used to deplete non-target cells and enrich CD4+ T cells. Subsequently, CD25 Capture Antibody specifically binds to CD25+ cells, which are then captured by Releasable Magnetic Beads. Following isolation, the magnetic beads are gently detached from the cell surface using Magnetic Beads Release Buffer, yielding label-free CD4+ CD25+ regulatory T cells with no residual magnetic beads.

Cell Biology Cell Isolation

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HY-K1043A Polyamine Supplement (1000×)

MCE Polyamine Supplement (1000×) can be used as a component of the CEPT Cocktail in combination with Emricasan, Chroman 1, and trans-ISRIB to enhance the survival of pluripotent stem cells (PSCs) and promote single-cell clonal expansion. In addition, this supplement improves the viability of PSCs and their differentiated derivatives during cryopreservation, organoid culture, single-cell cloning, and genome editing, thereby enhancing the robustness and reproducibility of downstream applications.

Cell Biology Cell Culture CEPT cocktail

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HY-K2034 OptiLNP Antibody-ctLNP RNA Transfection Reagent (Human Primary T Cells)

MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology and is specifically optimized for human primary T cells. It enables efficient and targeted RNA delivery, improving transfection efficiency in difficult-to-transfect primary T cells. The kit is ideally suited for applications including CAR-T and TCR-T cell engineering, cancer immunology research, immune cell engineering, and in vitro T cell functional studies.

Cell Biology Cell Culture Cell Transfection

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HY-K3030 Ham's F-12K (Kaighn's)

Ham’s F-12K Medium was originally designed for the culture of primary human hepatocytes and differentiated rat and chicken cells. It is particularly suitable for single-cell cloning of Chinese hamster ovary (CHO) cells under serum-free conditions. When supplemented with serum, it can also be used for the culture of various other mammalian cell types, including chondrocytes and rat prostate epithelial cells.

Cell Biology Cell Culture Basal Cell Culture Media

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HY-K6101 Human Breast Cancer Organoid Kit

MCE Human Breast Cancer Organoid Kit contains Breast Cancer Organoid Basal Medium A, Breast Cancer Organoid Supplement B (50×), Breast Cancer Organoid Supplement C (250×). This product can be used to efficiently construct human breast cancer organoid.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6102 Human Lung Adenocarcinoma Organoid Kit

MCE Human Lung Adenocarcinoma Organoid Kit contains Lung Adenocarcinoma Organoid Basal Medium A, Lung Adenocarcinoma Organoid Supplement B (50×), Lung Adenocarcinoma Organoid Supplement C (250×). This product can be used to efficiently construct human lung adenocarcinoma organoid.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6106 Human Cholangiocarcinoma Organoid Kit

MCE Human Cholangiocarcinoma Organoid Kit contains Cholangiocarcinoma Organoid Basal Medium A, Cholangiocarcinoma Organoid Supplement B (50×), Cholangiocarcinoma Organoid Supplement C (250×). This product can be used to efficiently construct human cholangiocarcinoma organoid.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6112 Human Colonic Organoid Kit

MCE Human Colonic Organoid Kit contains Human Colonic Organoid Basal Medium A, Human Colonic Organoid Supplement B (50×), Human Colonic Organoid Supplement C (250×), and Human Colonic Organoid Supplement D (250×). This product can be used to efficiently construct human colonic organoid.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

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HY-K6113 Human Intestinal Organoid Kit

MCE Human Intestinal Organoid Kit contains Intestinal Organoid Basal Medium A, Intestinal Organoid Supplement B (50×), Intestinal Organoid Supplement C (250×), and Intestinal Organoid Supplement D (250×). This product can be used to efficiently construct human intestinal organoid.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

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HY-K6114 Human Gastric Epithelial Organoid Kit

MCE Human Gastric Epithelial Organoid Kit contains Gastric Epithelial Organoid Basal Medium A, Gastric Epithelial Organoid Supplement B (50×), Gastric Epithelial Organoid Supplement C (250×), and Gastric Epithelial Organoid Supplement D (250×). This product can be used to efficiently construct human gastric epithelial organoid.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

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HY-K6115 Human Pancreatic Organoid Kit

MCE Human Pancreatic Organoid Kit contains Human Pancreatic Organoid Basal Medium A, Human Pancreatic Organoid Supplement B (50×), and Human Pancreatic Organoid Supplement C (250×).This product can be used to efficiently construct human pancreatic organoids.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

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HY-K6119 Mouse Intestinal Organoid Kit

MCE Mouse Intestinal Organoid Kit contains Mouse Intestinal Organoid Basal Medium A, Mouse Intestinal Organoid Supplement B (50×), Mouse Intestinal Organoid Supplement C (250×) and EDTA. This product can be used to efficiently construct mouse intestinal organoid.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

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HY-K6120 Mouse Colonic Organoid Kit

MCE Mouse Colonic Organoid Kit contains Colonic Organoid Basal Medium A, Colonic Organoid Supplement B (50×), Colonic Organoid Supplement C (250×), Colonic Organoid Supplement D (250×) and EDTA. This product can be used to efficiently construct mouse colonic organoid.

Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium

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Keywords

kidney development | nephron progenitor cells | DNA methylation | chromatin accessibility | Polycomb | enhancer-promoter interaction | single-cell epigenomics | renal organoids