2. Gene
  3. Kras - Kirsten rat sarcoma viral oncogene homolog Gene

Kras - Kirsten rat sarcoma viral oncogene homolog Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras

Gene ID: 16653 | Gene type: protein coding

About Kras

Chromosome 6: 145,162,425-145,195,965 reverse strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 201 orthologues, 35 paralogues and is associated with 90 phenotypes. Ubiquitous expression in CNS E18 (RPKM 17.), whole brain E14.5 (RPKM 16.2) and 26 other tissues.

Summary

Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate Cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Kras Products(8)

mRNA Protein Name
NM_001403242.1 NP_001390171.1 GTPase KRas isoform 1
NM_001403245.1 NP_001390174.1 GTPase KRas isoform 3
NM_001403241.1 NP_001390170.1 GTPase KRas isoform 1
NM_001403246.1 NP_001390175.1 GTPase KRas isoform 4
NM_021284.7 NP_067259.4 GTPase KRas isoform 1
NM_001403243.1 NP_001390172.1 GTPase KRas isoform 2
NM_001403240.1 NP_001390169.1 GTPase KRas isoform 1
NM_001403244.1 NP_001390173.1 GTPase KRas isoform 3

Kras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

GTPase KRas

Kirsten rat sarcoma oncogene 2, expressed

p21 protein

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114277 Sotorasib Inhibitor 99.94% Yes
HY-15136 Lonafarnib 99.87% Yes
HY-114277A Sotorasib racemate 98.99% Unkown
Clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-130149 Adagrasib Inhibitor 99.93% Phase 3
HY-145928 Divarasib Inhibitor 99.46% Phase 3
HY-139612 Opnurasib Inhibitor 98.94% Phase 3
HY-134813 MRTX1133 Inhibitor 99.42% Phase 2
HY-114491 Rineterkib Inhibitor 99.83% Phase 2
HY-N6674 Diazepinomicin 98.04% Phase 2
HY-153346 RMC-6291 99.65% Phase 1
HY-15610 GDC-0623 99.15% Phase 1
HY-16373 CP-609754 Inhibitor 99.87% Phase 1
HY-156002 LUNA18 Inhibitor 99.26% Phase 1
Pre-clinical Phase
Bioactive Molecules (261)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153724 BI-2865 99.65% Unkown
HY-126247 BI-2852 Inhibitor 99.57% Unkown
HY-125817 BI-3406 Inhibitor 99.95% Unkown
HY-114398 BAY-293 Inhibitor 95.77% Unkown
HY-112929 DT-061 Activator 99.95% Unkown
HY-137516 LC-2 Inhibitor ≥95.0% Unkown
HY-147214 GNE-7883 Inhibitor 98.42% Unkown
HY-U00418 ARS-1620 Inhibitor 99.62% Unkown
HY-135985 DCLK1-IN-1 Inhibitor 99.62% Unkown
HY-156498 RMC-7977 Inhibitor 99.12% Unkown
HY-114436 MRTX-1257 Inhibitor 99.14% Unkown
HY-15872A FTI-277 hydrochloride 98.00% Unkown
HY-129523 PROTAC K-Ras Degrader-1 Inhibitor 98.05% Unkown
HY-148098 Pan KRas-IN-1 Inhibitor 98.47% Unkown
HY-W451275 HG106 Inhibitor 99.95% Unkown
HY-128350 FGTI-2734 Inhibitor 99.64% Unkown
HY-19713 LJI308 Inhibitor 99.07% Unkown
HY-148409 MMRi62 99.58% Unkown
HY-15747 Deltarasin Inhibitor 99.89% Unkown
HY-141477 RM-018 Inhibitor 98.03% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.16% Unkown
HY-19706 ARS-853 98.39% Unkown
HY-153723 BI-2493 Inhibitor 99.70% Unkown
HY-156819 RMC-9805 Inhibitor 99.73% Unkown
HY-18674 K-Ras-IN-1 Inhibitor 98.05% Unkown
HY-138188 KRA-533 Agonist 98.94% Unkown
HY-132980 KRAS G12C inhibitor 19 Inhibitor 98.41% Unkown
HY-141807 MS21 99.88% Unkown
HY-128350A FGTI-2734 mesylate Inhibitor 99.05% Unkown
HY-145962A MRTX-EX185 formic Inhibitor 97.32% Unkown
HY-145571 Garsorasib Inhibitor 99.11% Unkown
HY-151523 KRas G12R inhibitor 1 Inhibitor 98.19% Unkown
HY-122914 KRAS inhibitor-3 Inhibitor 99.65% Unkown
HY-136265 BC-LI-0186 Inhibitor 98.85% Unkown
HY-128522 ARS-1323-alkyne Inhibitor 99.59% Unkown
HY-137497 KRAS inhibitor-9 99.85% Unkown
HY-132966 ASP2453 Inhibitor 98.04% Unkown
HY-144661 KRAS G12D inhibitor 14 99.39% Unkown
HY-139047 SW157765 Inhibitor 98.67% Unkown
HY-139186 PROTAC KRAS G12C degrader-1 99.55% Unkown
HY-P2265A SAH-SOS1A TFA Inhibitor 99.16% Unkown
HY-146223 AZD4625 Inhibitor 99.52% Unkown
HY-P3277 KRpep-2d Inhibitor 95.09% Unkown
HY-151881 SOS1-IN-15 Inhibitor 99.51% Unkown
HY-N0735 Phellodendrine chloride 99.79% Unkown
HY-142160 GNE-9815 Inhibitor 98.28% Unkown
HY-148278 BI-0474 Inhibitor 99.83% Unkown
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Unkown
HY-125872 KRAS G12C inhibitor 14 Inhibitor 98.07% Unkown
HY-128771 K-Ras G12C-IN-4 Inhibitor 98.60% Unkown
HY-151517 SOS1-IN-14 Inhibitor 99.38% Unkown
HY-156671 RMC-4998 96.33% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-16662 Oncrasin-1 98.28% Unkown
HY-158115 NST-628 Inhibitor / Unkown
HY-U00417 ARS-1630 Inhibitor 98.10% Unkown
HY-138295 KRAS inhibitor-10 Inhibitor 99.86% Unkown
HY-154959 AZD4747 Inhibitor 99.81% Unkown
HY-125873 KRAS G12C inhibitor 15 Inhibitor 99.55% Unkown
HY-147008 XP-524 Inhibitor 99.66% Unkown
HY-112929B (1S,2S,3R)-DT-061 99.73% Unkown
HY-114398A (S)-BAY-293 / Unkown
HY-126247B (R)-BI-2852 97.32% Unkown
HY-130819 Tos-PEG4-THP ≥95.0% Unkown
HY-145737A PROTAC SOS1 degrader-1 TFA Agonist 99.38% Unkown
HY-U00416 ARS-1323 Inhibitor 99.14% Unkown
HY-148273 Setidegrasib Inhibitor 99.65% Unkown
HY-18606 K-Ras G12C-IN-3 Inhibitor 99.94% Unkown
HY-122641 Deltasonamide 1 Inhibitor 99.15% Unkown
HY-143589 Glecirasib Inhibitor / Unkown
HY-145615 Pomalidomide-C12-NH2 hydrochloride 97.09% Unkown
HY-153821 PROTAC KRAS G12C degrader-2 Degrader 98.45% Unkown
HY-154313 Spiclomazine Inhibitor 99.95% Unkown
HY-18604 K-Ras G12C-IN-1 Inhibitor 98.19% Unkown
HY-157029S KRASG12D-IN-1 Inhibitor 98.07% Unkown
HY-142460 KRAS G12C inhibitor 28 Inhibitor 99.94% Unkown
HY-145962 MRTX-EX185 Inhibitor / Unkown
HY-128590 PHT-7.3 Inhibitor 98.50% Unkown
HY-130707 K-Ras ligand-Linker Conjugate 3 / Unkown
HY-130991 K-Ras ligand-Linker Conjugate 6 95.18% Unkown
HY-134811 KRAS G12D inhibitor 1 Inhibitor 98.45% Unkown
HY-107720 ARL 17477 Inhibitor 99.02% Unkown
HY-112491 KRas G12C inhibitor 1 Inhibitor / Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-130820 THP-PEG4-Pyrrolidine(N-Boc)-CH2OH ≥95.0% Unkown
HY-130821 THP-PEG4-Pyrrolidine(N-Me)-CH2OH ≥95.0% Unkown
HY-134977 Atrovastatin-PEG3-FITC Inhibitor 98.17% Unkown
HY-136726 CGP-82996 Inhibitor / Unkown
HY-139612A (S)-JDQ-443 Inhibitor 99.32% Unkown
HY-153413 Kras4B G12D-IN-1 Inhibitor 98.01% Unkown
HY-162065 N6F11 Inducer / Unkown
HY-P3277A KRpep-2d TFA Inhibitor 98.11% Unkown
HY-W016889 CFL-137 Inhibitor 99.53% Unkown
HY-12446 K-Ras(G12C) inhibitor 9 Inhibitor ≥98.0% Unkown
HY-15747A Deltarasin hydrochloride Inhibitor 98.07% Unkown
HY-15872 FTI-277 / Unkown
HY-18605 K-Ras G12C-IN-2 Inhibitor 99.21% Unkown
HY-135864 KRAS inhibitor-6 Inhibitor / Unkown
HY-135865 KRAS inhibitor-7 Inhibitor / Unkown
HY-135866 KRAS inhibitor-8 Inhibitor / Unkown
HY-157031S KRASG12D-IN-2 Inhibitor 98.11% Unkown
HY-158107 BBO-8520 Inhibitor / Unkown
HY-115880 KRAS G12D inhibitor 3 Inhibitor / Unkown
HY-129775 K-Ras ligand-Linker Conjugate 1 / Unkown
HY-129776 K-Ras ligand-Linker Conjugate 2 / Unkown
HY-132920 KRAS mutant protein inhibitor 1 Inhibitor / Unkown
HY-139894 KRAS G12D inhibitor 5 Inhibitor / Unkown
HY-142458 KRAS G12C inhibitor 27 Inhibitor / Unkown
HY-142487 KRAS G12C inhibitor 32 Inhibitor / Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-114168 KRAS G12C inhibitor 5 Inhibitor / Unkown
HY-125874 KRAS G12C inhibitor 16 Inhibitor / Unkown
HY-125875 KRAS G12C inhibitor 17 Inhibitor / Unkown
HY-126292 KRAS G12C inhibitor 13 Inhibitor / Unkown
HY-130260 KRAS inhibitor-4 Inhibitor / Unkown
HY-130822 K-Ras ligand-Linker Conjugate 4 95.06% Unkown
HY-130823 K-Ras ligand-Linker Conjugate 5 96.96% Unkown
HY-132979 KRAS G12C inhibitor 18 Inhibitor / Unkown
HY-146544 KRAS inhibitor-14 Inhibitor / Unkown
HY-146546 KRAS inhibitor-16 Inhibitor / Unkown
HY-150926 G12Si-1 Inhibitor / Unkown
HY-150927 G12Si-2 Inhibitor / Unkown
HY-151287 KRAS inhibitor-20 Inhibitor / Unkown
HY-152848 Fulzerasib Inhibitor / Unkown
HY-153262 KRASG12C IN-2 Inhibitor / Unkown
HY-160699 DCC-3116 Inhibitor / Unkown
HY-161235 BTX-7312 Degrader / Unkown
HY-162249 ASP6918 Inhibitor / Unkown
HY-108436 Deltazinone 1 Inhibitor / Unkown
HY-112492 KRas G12C inhibitor 2 Inhibitor / Unkown
HY-112493 KRas G12C inhibitor 3 Inhibitor / Unkown
HY-112494 KRas G12C inhibitor 4 Inhibitor / Unkown
HY-114277S Sotorasib-d7 Inhibitor / Unkown
HY-114436S MRTX-1257-d6 / Unkown
HY-115880A KRAS G12D inhibitor 3 TFA Inhibitor / Unkown
HY-115907 K20 Inhibitor / Unkown
HY-122152 Spiclomazine hydrochloride Inhibitor / Unkown
HY-122641D Deltasonamide 1 TFA Inhibitor 99.70% Unkown
HY-124761 Poloppin Inhibitor / Unkown
HY-125335 Oligomycin D / Unkown
HY-13497 STK33-IN-1 Inhibitor / Unkown
HY-137516A LC-2 epimer / Unkown
HY-139402 MRTX849 acid Inhibitor 99.84% Unkown
HY-139403 MRTX849 ethoxypropanoic acid Antagonist / Unkown
HY-139910 KRAS G12D inhibitor 6 Inhibitor / Unkown
HY-139911 KRAS G12D inhibitor 7 Inhibitor / Unkown
HY-142457 KRAS G12C inhibitor 26 Inhibitor / Unkown
HY-142478 KRAS G12C inhibitor 29 Inhibitor / Unkown
HY-142481 KRAS G12C inhibitor 30 Inhibitor / Unkown
HY-142485 KRAS G12C inhibitor 31 Inhibitor / Unkown
HY-142490 KRAS G12C inhibitor 33 Inhibitor / Unkown
HY-142511 KRAS G12C inhibitor 34 Inhibitor / Unkown
HY-142945 KRAS G12C inhibitor 43 Inhibitor / Unkown
HY-142946 KRAS G12C inhibitor 44 Inhibitor / Unkown
HY-142947 KRAS G12C inhibitor 45 Inhibitor / Unkown
HY-142948 KRAS G12C inhibitor 46 Inhibitor / Unkown
HY-143359 COTI-219 Inhibitor / Unkown
HY-143588 KRAS G12C inhibitor 35 Inhibitor / Unkown
HY-143590 KRAS G12C inhibitor 37 Inhibitor / Unkown
HY-143591 KRAS G12C inhibitor 38 Inhibitor / Unkown
HY-143592 KRAS G12C inhibitor 39 Inhibitor / Unkown
HY-143594 KRAS G12C inhibitor 40 Inhibitor / Unkown
HY-143596 KRAS G12C inhibitor 41 Inhibitor / Unkown
HY-143598 KRAS G12C inhibitor 42 Inhibitor / Unkown
HY-143599 KRAS G12D inhibitor 8 Inhibitor / Unkown
HY-143602 KRAS G12D inhibitor 9 Inhibitor / Unkown
HY-143603 KRAS G12D inhibitor 10 Inhibitor / Unkown
HY-143604 KRAS G12D inhibitor 11 Inhibitor / Unkown
HY-143606 KRAS G12D inhibitor 12 Inhibitor / Unkown
HY-143607 KRAS G12D inhibitor 13 Inhibitor / Unkown
HY-144207 SOS1-IN-9 Inhibitor / Unkown
HY-144210 SOS1-IN-6 Inhibitor / Unkown
HY-144211 SOS1-IN-7 Inhibitor / Unkown
HY-144213 SOS1-IN-10 Inhibitor / Unkown
HY-144323 YF135 Inhibitor / Unkown
HY-144657 (4S)-PROTAC SOS1 degrader-1 Inhibitor / Unkown
HY-145017 KRAS G12C inhibitor 20 Inhibitor / Unkown
HY-145018 KRAS G12C inhibitor 21 Inhibitor / Unkown
HY-145019 KRAS G12C inhibitor 22 Inhibitor / Unkown
HY-145020 KRAS G12C inhibitor 23 Inhibitor / Unkown
HY-145022 KRAS G12C inhibitor 25 Inhibitor / Unkown
HY-145047 SOS1-IN-4 Inhibitor / Unkown
HY-145048 SOS1-IN-5 Inhibitor / Unkown
HY-145436 KRAS inhibitor-11 Inhibitor / Unkown
HY-145737 PROTAC SOS1 degrader-1 Agonist / Unkown
HY-146061 KRAS G12C inhibitor 48 Inhibitor / Unkown
HY-146223A (3R,10R,14aS)-AZD4625 / Unkown
HY-146243 TH-Z835 / Unkown
HY-146475 KRAS inhibitor-17 Inhibitor / Unkown
HY-146476 KRAS inhibitor-18 Inhibitor / Unkown
HY-146533 KRAS inhibitor-12 Inhibitor / Unkown
HY-146537 KRAS G12C inhibitor 47 Inhibitor / Unkown
HY-146543 KRAS inhibitor-13 Inhibitor / Unkown
HY-146545 KRAS inhibitor-15 Inhibitor / Unkown
HY-147595 KRAS G12D inhibitor 15 Inhibitor / Unkown
HY-147631 KRAS G12C inhibitor 50 Inhibitor / Unkown
HY-147632 KRAS G12C inhibitor 51 Inhibitor / Unkown
HY-147633 KRAS G12C inhibitor 52 Inhibitor / Unkown
HY-147634 KRAS G12C inhibitor 53 Inhibitor / Unkown
HY-147635 KRAS G12C inhibitor 54 Inhibitor / Unkown
HY-147636 KRAS G12C inhibitor 55 Inhibitor / Unkown
HY-148260 KRAS G12D inhibitor 16 Inhibitor / Unkown
HY-148261 KRAS G12C inhibitor 56 Inhibitor / Unkown
HY-149607 SHP2-IN-22 Inhibitor / Unkown
HY-149705 ICMT-IN-7 Inhibitor / Unkown
HY-149709 ICMT-IN-35 Inhibitor / Unkown
HY-151288 KRAS inhibitor-21 Inhibitor / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-151571 ZG1077 Inhibitor / Unkown
HY-151968 KRAS G12C inhibitor 57 Inhibitor / Unkown
HY-151999 KRASG12C IN-1 Inhibitor / Unkown
HY-152145 PROTAC SOS1 degrader-3 / Unkown
HY-152248 ARS-2102 Inhibitor / Unkown
HY-153412 KRAS inhibitor-22 Degrader / Unkown
HY-153461 KRAS G12C inhibitor 58 Inhibitor / Unkown
HY-153555 KRAS G12D modulator-1 Modulator / Unkown
HY-153662 TH-Z816 Inhibitor / Unkown
HY-153663 TH-Z827 Inhibitor / Unkown
HY-153880 KRAS degrader-1 Degrader / Unkown
HY-153881 PROTAC KRAS G12C degrader-3 / Unkown
HY-153899 KRAS G12C inhibitor 59 Inhibitor / Unkown
HY-153940 SOS1/KRAS-IN-1 Inhibitor / Unkown
HY-153944 KRAS G12C inhibitor 60 Inhibitor / Unkown
HY-156363 K-Ras-IN-2 Inhibitor / Unkown
HY-156500 ICMT-IN-1 Inhibitor / Unkown
HY-156528 pan-KRAS-IN-4 Inhibitor / Unkown
HY-156529 pan-KRAS-IN-2 Inhibitor / Unkown
HY-156549 KRAS G12C inhibitor 61 Inhibitor / Unkown
HY-156555 pan-KRAS-IN-3 / Unkown
HY-157228 ACBI3 / Unkown
HY-157458 PDEδ autophagic degrader 1 / Unkown
HY-158008 (R)-G12Di-7 Inhibitor / Unkown
HY-161066 KRAS G13D-IN-1 Inhibitor / Unkown
HY-161173 PROTAC SOS1 degrader-5 / Unkown
HY-161176 PROTAC KRAS G12D degrader 1 Degrader / Unkown
HY-161177 PROTAC KRAS G12D degrader 2 Inhibitor / Unkown
HY-161233 BTX-6654 Inhibitor / Unkown
HY-161234 KRAS ligand 3 / Unkown
HY-161236 KRAS ligand 4 Inhibitor / Unkown
HY-162112 KRB-456 Inhibitor / Unkown
HY-162281 PROTAC SOS1 degrader-6 Inhibitor / Unkown
HY-162321 ZINC57632462 Inhibitor / Unkown
HY-162366 KRAS G12D inhibitor 20 Inhibitor / Unkown
HY-163299 pan-KRAS-IN-5 / Unkown
HY-N8387 Neogrifolin Inhibitor / Unkown
HY-P2265 SAH-SOS1A Inhibitor / Unkown
HY-RS07425 KRAS Human Pre-designed siRNA Set A / Unkown
HY-RS07426 Kras Mouse Pre-designed siRNA Set A / Unkown
HY-RS07427 Kras Rat Pre-designed siRNA Set A / Unkown
HY-W041315 CFL-120 Inhibitor ≥98.0% Unkown
HY-114277B Sotorasib isomer 99.09% Unkown
HY-144657A (4S)-PROTAC SOS1 degrader-1 diTFA Inhibitor 98.09% Unkown
HY-145928B Divarasib adipate Inhibitor / Unkown
HY-149710 POP-3MB Inhibitor / Unkown
HY-154959A (9R,12aR)-AZD4747 98.90% Unkown
HY-157067 KRAS G12C inhibitor 62 Inhibitor / Unkown
HY-160220S KRAS inhibitor-23 Inhibitor / Unkown
HY-160445 KRAS G12D inhibitor 19 / Unkown
HY-W335254 Deltarasin trihydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kras NCBI NCBI:3845