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A Novel AI-Based Joint Modeling Approach for Brain-Behavior Dynamics

Neurodegeneration Intercellular Communication & Diseases Cellular Degeneration Multiprotein Complexes and Disease

Joint brain-behavior modeling uses artificial intelligence to learn shared structure between neural activity and behavior rather than analyzing either domain independently; current approaches include discriminative, generative, and contrastive models, alongside increasingly sophisticated behavioral representations from pose estimation, hierarchical analysis, and multimodal models. The field builds on advances in computational neuroscience, high-dimensional neural recording, machine learning, and automated behavioral measurement, and recent synthesis in Nature Reviews Neuroscience identifies joint modeling as an active methodological frontier for linking neural dynamics to observable behavior. Modern pose-estimation systems strengthen this framework by converting video into temporally resolved behavioral trajectories while using semi-supervised learning, motion continuity, multiview geometry, posture constraints, temporal context, ensembling, and Kalman smoothing to improve scientific usability. These developments are significant because richer behavioral measurements can be aligned with neural population dynamics, allowing models to characterize relationships that conventional brain-only or behavior-only analyses may not expose. Mechanistically, this approach operates computationally rather than through a single molecular signaling pathway or protein target[1][2].

One implementation jointly models resting-state functional MRI connectivity and diffusion-tensor tractography: structurally regularized dynamic dictionary learning decomposes dynamic functional-connectivity matrices into shared basis networks and time-varying subject-specific loadings, DTI tractography supplies anatomical regularization, and an LSTM-artificial neural network uses temporal loading trajectories to predict multidimensional behavioral or clinical measures. Joint optimization estimates basis networks, temporal subject loadings, and neural-network weights together, thereby coupling brain organization directly to behavioral prediction. A complementary multiscale strategy models spike and local-field-potential observations while explicitly representing regime-dependent switching in neural dynamics; its unsupervised algorithm fuses information across neural scales and decodes behavior more accurately than switching single-scale models in the reported experimental datasets. These architectures therefore treat temporally evolving latent neural states, multimodal fusion, structural constraints, and behavioral prediction as interacting components of one model rather than invoking biochemical activation or inhibition. Disease-oriented applications remain primarily computational and biomarker-focused[1][3][4].

The dynamic connectomics framework was evaluated for cognitive mapping in neurotypical Human Connectome Project data and for multidimensional clinical prediction in autism spectrum disorder, where the hybrid model produced interpretable multimodal signatures of brain organization and improved clinical-outcome prediction relative to the reported comparison approaches. Multiscale switching models have additionally been proposed to improve the robustness of brain-computer interfaces while advancing understanding of how behavior is encoded by changing neural population dynamics. However, the literature identifies major unresolved issues: joint models must accommodate complex behavioral dynamics, heterogeneous neural measurements, non-stationarity, limited labels, and the need for trustworthy and interpretable outputs. Future work can integrate improved pose estimation, hierarchical behavioral representations, multimodal-language approaches, dynamic neural-state models, and explicit interpretability or trustworthiness evaluation. The resulting research direction is therefore better supported as a platform for neuroscience, neurodevelopmental phenotyping, neural decoding, and brain-computer-interface development than as a direct molecular drug-discovery mechanism; the retrieved evidence does not establish a specific protein target or druggable signaling pathway.[1][2][3][4].

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Cat. No. Product Name Information Application Publication
HY-B0141C Estradiol hemihydrate
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.
Estrogen Receptor/ERR   Endogenous Metabolite   Bacterial  
Viral Infection   Bacterial Infection   Neurodegenerative Disease   Metastatic Breast Cancer  
141
HY-B0141 Estradiol
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.
Estrogen Receptor/ERR   Endogenous Metabolite   Bacterial  
Metabolic or Endocrine Disease   Prostate Cancer   Viral Infection   Bacterial Infection   Neurodegenerative Disease   Cardiovascular Disease   Luminal Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection  
141
HY-L030 Human Endogenous Metabolite Compound Library
The composition of endogenous metabolite compounds is affected by the upstream influence of the proteome and genome as well as environmental factors, lifestyle factors, medication, and underlying disease. Therefore, metabolites have been described as proximal reporters of disease because their abundances in biological specimens are often directly related to pathogenic mechanisms. In more recent years, metabolomics approach has been adopted or suggested to be used in various research areas including drug discovery, neurosciences, agriculture, food and nutrition, and environmental sciences. MCE owns a unique collection of 765 human endogenous metabolites, all of which are derived from human issues. This library is a powerful tool for metabonomics research and metabolism-related drug discovery.

Metabolism Focused Libraries

91
HY-L052 Anti-COVID-19 Compound Library
COVID-19 poses a serious threat to people's health, and it is urgent to develop drugs to treat COVID-19 quickly. The screening of anti-COVID-19 drugs by using the clinical and approved compounds can greatly shorten the research and development cycle. In addition, the virtual screening technology can effectively narrow the scope of screening and improve the screening efficiency in the pre-screening of new drugs. Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease (PDB ID: 6LU7), Spike Glycoprotein (PDB ID: 6VSB), NSP15 (PDB ID: 6VWW), RDRP, PLPro and ACE2 (Angiotensin Converting Enzyme 2) structure. We design a unique collection of 1,380 compounds which may have anti-COVID-19 activity. Anti-COVID-19 Compound Library will be a powerful tool for screening new anti-COVID-19 activity drugs.

Disease Focused Libraries

90
HY-L057 Phenols Library
Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders. MCE offers a unique collection of 1,299 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

Structure Classified Natural Product Libraries

87
HY-L008 JAK/STAT Compound Library
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 738 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Signaling Pathway Targeting Libraries

86
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L109 Protein-protein Interaction Inhibitor Library
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 826 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

Signaling Pathway Targeting Libraries

86
HY-L095 Mechanoreceptors Compound Library
Mechanoreceptors convert different stimuli from the outside into electrical signals, enabling us to quickly respond to our environment. Mechanoreceptors are distributed throughout the body, including in the skin, tendons, muscles, joint capsules and viscera. In addition to the channels of TRP and Piezo mentioned in the Nobel Prize, there are also targets such as KCNK, ENaC and ASIC2, which play an important role in the environment perception and homeostasis of living organisms. MCE offers a unique collection of 391 compounds related to mechanoreceptors, which targeting different mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc. MCE mechanoreceptors compound library is a powerful tool for studying mechanoreceptors and life perception.

Signaling Pathway Targeting Libraries

85
HY-L123 Human Metabolite Library
Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development. MCE offers a unique collection of 6,767 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Metabolism Focused Libraries

85
HY-L143 Marine-Sourced Natural Product Library
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 60 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Natural Product Screening Libraries

85
HY-L013 Neuronal Signaling Compound Library
Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders. MCE designs a unique collection of 3,961 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Signaling Pathway Targeting Libraries

84
HY-L016 Protein Tyrosine Kinase Compound Library
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1,695 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Signaling Pathway Targeting Libraries

84
HY-L060 Cytoskeleton Compound Library
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 2,313 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L069 Anti-Alzheimer's Disease Compound Library
Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc. MCE offers a unique collection of 2,174 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

Disease Focused Libraries

84
HY-L114 Anti-inflammatory Traditional Chinese Medicine Active Compound Library
Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes. Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1,665 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Disease Focused Libraries Traditional Chinese Medicine Libraries

84
HY-L121 5-HT Receptor Compound Library
5-HT receptors, also called Serotonin receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. These receptors are now classified into seven families, 5-HT1–7, comprising a total of 14 structurally and pharmacologically distinct mammalian 5-HT receptor subtypes. The 5-HT receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens. MCE 5-HT Receptor Compound Library consists of 430 5-HT receptor inhibitors and activators, which can be used for neuropsychiatric disorders drugs discovery.

Signaling Pathway Targeting Libraries

84
HY-E0156 8-Channel Handheld Screw Cap Decapper

MCE 8-Channel Handheld Screw Cap Decapper is a necessary tool for handling thousands of screw cap tubes. It can cap and open various types of screw cap tubes, making it convenient and fast to operate. This improves experimental efficiency and meets different needs.
83
HY-L0091V Chemspace Lead-Like Compound Library
Chemspace Lead-Like Compound Library contains 1,367,511 in-Stock lead-like compoundswith favorable physicochemical profiles and high Quantitative Estimation of Drug-likeness.
83
HY-L0115V Asinex Macrocycles Library
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks. Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
83
HY-L0119V Asinex PPI Pre-Plated Library
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.
83
HY-L0123V Life Chemicals CNS Focused Screening Library
The incidence and significance of central nervous system diseases are increasing at an alarming rate all over the world. Although substantial research efforts have been applied to develop new CNS-active drugs, only a few CNS disorders are addressed satisfactorily, while the remaining ones pose significant clinical challenges. Blood-brain barrier (BBB) permeability is one of the most important limiting factors in the design and development of novel CNS-targeted pharmaceuticals for the treatment of neurological disorders. Carefully selected from the HTS Compound Collection to meet the parameters optimized for high BBB-permeability, our CNS Focused Screening Library comprising over 30,300 structurally-diverse and potentially CNS-active screening compounds. This original Screening Compound Library is aimed at supporting CNS drug design projects and HTS efforts in search for novel neurotherapeutics.
83
HY-L0130V MCE Virtual Screening Compound Library2
A collection of over 10 million screening compounds from 18+ manufacturers. The data has been cleaned, suitable for virtual screening and AI screening.
83
HY-L097 Animal Disease Model Inducer Library
Animal disease models are used in a variety of settings in basic research, such as studies on mechanisms of disease progression and evaluation new drugs. Animal models can be broadly classified into five categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan, 5) genetically engineered. Experimental models, which are induced artificially in the laboratory, are most common. Some small molecular compounds are usually used as inducers for animal models, such as Ceruletide for inflammatory model, Azoxymethane for tumor model. These inducers are useful tool in building animal models. MCE offers a unique collection of 52 animal model inducers, involving inflammatory model, tumor model, nervous disease model, etc. MCE Animal Disease Model library is a powerful tool for the establishment of animal disease models.

Compound Characteristic Classified Libraries

83
HY-L100 Tumorigenesis-Related Compound Library
Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 147 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

Compound Characteristic Classified Libraries

83
HY-L110 Cyclic Peptide Library
Cyclic peptides are polypeptide chains taking cyclic ring structure, which exhibit diverse biological activities, such as antibacterial activity, immunosuppressive activity and anti-tumor activity. Cyclic peptides, with the features of good binding affinity, target selectivity and low toxicity, show great success as therapeutics. Multiple cyclic peptides are currently in clinical use, for examples, gramicidin and tyrocidine with bactericidal activity, cyclosporin A with immunosuppressive activity, and vancomycin with antibacterial activity. Furthermore, cyclic peptides usually have the sufficient size and a balanced conformational flexibility/rigidity for binding to flat protein-protein interaction (PPI) interfaces, which have potential to develop PPI drugs. MCE offers a unique collection of 100 cyclic peptides, all of which have good bioactivities. MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

Structure Classified Libraries

83
HY-L157 Animal-Sourced Natural Product Library
Natural product have great diversity and structural complexity of scaffolds. And the number of their drugs represents a large number of sources of new pharmacological entities, so natural products are of great significance in drug discovery. The Dictionary of Natural Products (DNP) shows that natural products mainly come from plants, animals and microorganisms, and animal sources are the second important source of natural products. Animal derived natural products exist to varying degrees in almost all forms of animals, generally secondary metabolite extracted from organisms. MCE provides a unique collection of 988 animal-sourced natural products. MCE Animal-Sourced Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Natural Product Screening Libraries

83
HY-L174 Macrophage Related Compound Library
Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 276 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L197 Vitamin Compound Library
Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases. MCE included 136 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.
83
HY-L201 Cell Proliferation Compound Library
Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others. MCE collects 3,628 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Signaling Pathway Targeting Libraries

83
HY-L208 Bile Acids Library
Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases. MCE included 62 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.
83
HY-L210 Anti-Rheumatic Arthritis Compound Library
Rheumatoid Arthritis (RA) is a autoimmune disease characterized by persistent joint inflammation. The pathology of RA includes immune cell infiltration, synovial lining proliferation, pannus formation, and the destruction of joint cartilage and bone, which is highly disabling. Due to long-term chronic inflammation, RA not only severely affects the quality of life of patients but can also damage multiple organs, leading to lung diseases, cardiovascular diseases, and malignant tumors. The pathogenesis of RA is complex, involving genetic, environmental, and immune factors. With the advancement of high-throughput screening technology, screening for compounds targeting JAK, CCR, MEK, MMP targets may contribute to the development of more effective drugs against Rheumatoid Arthritis (RA). MCE has collected 2,023 small molecule compounds with definite or potential anti-rheumatoid arthritis activity. This library is of significant value for researching the anti-RA drugs.
83
HY-L212 Neuropeptide Library
Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain. MCE can provide 128 neuropeptides that can be used for scientific research.
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HY-L215 Mass Spectrometry Human Metabolite Library
Metabolomics, positioned as the systemic characterization of small-molecule metabolites within biological systems, has emerged as an indispensable analytical platform in both fundamental research and translational applications across plant sciences, microbial biotechnology, and biomedical investigations. Functioning as a critical component in multi-omics integration, this discipline deciphers the intricate molecular networks operating downstream of genomic, transcriptomic, and proteomic regulation, thereby capturing the dynamic biochemical phenotype closest to organismal functionality. The metabolome, comprising endogenous compounds with molecular weights typically below 1500 Da, serves as the functional readout of cellular processes and environmental interactions, where perturbations in metabolic networks are frequently implicated in disease pathogenesis. Such unique attributes have propelled metabolomics into a pivotal role in pharmacological research, particularly in target deconvolution, pharmacodynamic assessment, and mechanistic elucidation of pathological processes. MCE can provide 6,077 mass spectrometry human metabolites that can be used for metabolite identification and quantification, functional cell detection and phenotypic screening of mass spectrometry.

Metabolism Focused Libraries

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HY-L217 Mouse Metabolite Compound Library
Metabolic abnormalities lead to dysfunction of metabolic pathways and the accumulation or lack of metabolites, which are recognized hallmarks of the disease. The metabolite signature is closely related to the disease phenotype and is very useful for predicting the diagnosis and prognosis of the disease as well as monitoring treatment. Metabolites can be used as disease markers for diagnostic therapy. As the classic model of disease experiment in vivo, mice metabolites also play a role in disease diagnosis and mechanism research. MCE provides 330 mouse metabolites that can be used in disease research.

Metabolism Focused Libraries

83
HY-L244 High-Efficiency Gene Editing Compound Library
In this era of rapid advancement in gene-editing technology, the CRISPR-Cas system, with its powerful programmability, is leading a transformation in life sciences research. It enables efficient and precise targeted modification of an organism's genome, providing a robust tool for studying gene function, treating genetic diseases, and improving crop varieties. However, bottlenecks such as insufficient editing efficiency, low homologous directed repair efficiency, and potential off-target risks remain major challenges in achieving precise genetic modifications and developing gene therapies. To overcome these limitations, the MCE High-Efficiency Gene Editing Compound Library systematically includes 761 small molecules that are known or have the potential to enhance gene-editing efficiency. These compounds work by targeting and modulating the DNA damage repair network, mechanistically inhibiting non-homologous end joining, promoting homologous directed repair, or regulating chromatin states and cellular responses, thereby significantly optimizing editing outcomes. This library is suitable for developing "CRISPR-small molecule" combination therapy strategies, improving gene-editing efficiency, and providing a powerful tool for in-depth research into the mechanisms of DNA damage repair in gene editing.

Signaling Pathway Targeting Libraries

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HY-L245 Natural Product Diversity Scaffold Library
At the forefront of innovative drug discovery, every medicinal chemist faces the challenge of rapidly identifying high-quality hit compounds from vast repositories of chemical resources. The MCE Natural Product Diversity Scaffold Library is the result of a streamlined optimization process built upon our existing natural product collection. Adhering to the rigorous selection principle of "retaining only one representative compound per BMS scaffold", we have concentrated the diversity of thousands of compounds into a high-value, low-redundancy core set containing 2,256 compounds. All compounds are derived from natural sources, inheriting their inherent advantages of structural complexity and drug-likeness. By eliminating redundancy, the library size is significantly reduced without any compromise to chemical diversity. This approach effectively lowers the cost and time required for primary screening while simplifying downstream data analysis and structure-activity relationship (SAR) studies.

Natural Product Screening Libraries

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HY-L247 Environmental Pollutant Compound Library
Environmental pollution refers to the process where human activities release harmful chemicals or energy (such as industrial waste, pesticides, and plastic particles) into the natural environment at a rate that exceeds the ecosystem's capacity for self-purification, leading to deterioration in the composition or state of the atmosphere, water bodies, and soil. Environmental pollution is not only a direct threat to biodiversity but also ultimately impacts human health through the bioaccumulation effect of the food chain. Therefore, the accurate identification and dynamic monitoring of pollutants constitute the scientific cornerstone for formulating environmental policies, assessing ecological risks, and promoting green chemistry transformation. MCE features a collection of 296 environmental pollutants, covering categories such as air pollutants, water pollutants, and pesticides, for research in the field of environmental chemistry.

Compound Characteristic Classified Libraries

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HY-L252 Carbohydrate Metabolite Compound Library
Carbohydrate metabolism serves as a central hub for energy supply and biosynthesis in living organisms and plays a critical role in the onset and progression of various diseases. In recent years, studies have shown that tumor cells reprogram their energy metabolism through aerobic glycolysis (the Warburg effect) to support rapid proliferation. Immune cells also rely on specific carbohydrate metabolic pathways to regulate their activation and differentiation states, while disorders such as diabetes and metabolic syndrome arise directly from dysregulation of carbohydrate metabolism. In addition, enzymes and key metabolic nodes involved in carbohydrate metabolism have become important targets for drug discovery, and therapeutic strategies targeting glycolysis, the pentose phosphate pathway, and energy metabolism are continuously advancing the treatment of cancer and metabolic diseases. Therefore, systematic analysis of carbohydrate metabolic networks and their associated metabolites is of great significance for elucidating disease mechanisms and developing novel therapeutic approaches. The MCE Carbohydrate Metabolism Metabolite Library is constructed based on classical carbohydrate metabolic pathways and contains 76 metabolites. It systematically integrates key metabolic networks, including glycolysis, the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle, monosaccharide metabolism, and sugar acid interconversions. The library comprehensively covers core metabolic nodes from glucose uptake and utilization to energy production and biosynthesis, while also incorporating important upstream and downstream intermediates. It enables accurate representation of intracellular metabolic flux dynamics and is well suited for applications such as metabolic flux analysis, target validation, and mechanistic studies. Furthermore, it provides robust support for multi-omics integration and the development of precision intervention strategies.
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HY-L906 Norepinephrine Transporter (NET) Compound Library
On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters. The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter.

Focused and target libraries

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HY-L913 Tyrosine Focused Covalent Fragment Library
Recently, significant advancements in tyrosine-targeting electrophiles have primarily occurred in the field of protein-protein interactions (PPIs), where cysteine residues are often underrepresented and novel chemistries are needed to address these interfaces. In this context, tyrosines are frequently more accessible compared to more buried binding sites. Moreover, they are commonly found at "hot spots," which are functional epitopes of PPIs, with 12.3% of the residues consisting of tyrosines. This prevalence is likely due to the hydrophobic nature of tyrosine, its ability to participate in aromatic π-interactions, and its capacity for hydrogen bonding. Beyond PPIs, some progress has also been made in covalent tyrosine targeting in other areas where more commonly addressed side chains are lacking. Even though tyrosine has a slightly lower pKa value compared to the protonated lysine side chain (approximately 10 vs. 10.5 for the unprotected amino acid side chains), significantly less progress has been made in the development of tyrosine-targeted covalent ligands compared to lysine. This is likely due to the reduced flexibility of the tyrosine side chain and the greater steric hindrance of its hydroxy group, which makes it more challenging to adopt suitable reaction geometries. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 124 fragment molecules which can target tyrosine residue and can be used for fragment-based covalent drug discovery.

Functional Fragment Libraries

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HY-L915 Lysine Focused Covalent Fragment Library
Lysine is the second most common target residue used in the design of TCIs and related covalent ligands. Its appeal lies in its abundance in human proteins, which is approximately three times higher than that of cysteine (5.8% vs. 1.9%). This significantly increases the number of proteins suitable for covalent targeting, especially given that many human proteins lack ligandable cysteine residues. Moreover, it has been suggested that functional lysines have a lower probability of being replaced by mutation, as they often play a crucial role in catalysis by acting as bases or nucleophiles. Additionally, lysines are essential for maintaining the structural integrity of proteins and for regulating post-translational modifications (PTMs). Consequently, targeting lysine has garnered significant interest in recent years. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 445 fragment molecules which can target lysine residue and can be used for fragment-based covalent drug discovery.

Functional Fragment Libraries

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HY-L916 Multifunctional Covalent Fragment Library
Different functional groups confer unique chemical properties and reactivity characteristics to compounds. The presence of these functional groups not only affects the physical properties of the compounds, such as solubility and boiling point, but also determines their chemical reactivity and potential applications in chemical synthesis. Covalent ligands rely on reactive groups (“warheads”), and new warheads are key to expanding the scope of covalent modalities. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 4,900 multifunctional covalent fragments.

Featured Fragment Libraries

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HY-L917 RNA Binding Library
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs. MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.

Focused and target libraries

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HY-L918 Molecular Glue-like Compound Library
Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms. Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases. Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Focused and target libraries

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HY-L919 MCE CNS BBB Lead-like Library
With the aging population and increasing competitive pressures, neurodegenerative diseases of the central nervous system (CNS) have become a serious medical challenge in modern society, including Parkinson's disease, Alzheimer's disease, brain tumors, and multiple sclerosis. However, the success rate of CNS drug development remains remarkably low, primarily due to the blood-brain barrier (BBB). The blood-brain barrier (BBB) is a semipermeable barrier structure that surrounds the microvasculature of the CNS. In capillaries, the wedged endothelial cells are tightly packed and wedge-shaped, lining the interior of the vessels to form extensive tight junctions. Along with a range of receptors, transporters, efflux pumps, and other cellular components, this barrier regulates the entry and exit of molecules between the bloodstream and the brain. The intact BBB blocks the passage of most blood-borne substances into the brain, preventing nearly 100% of large-molecule drugs and over 98% of small-molecule drugs from entering. Compared to non-CNS drugs, physicochemical properties such as hydrogen bonds, lipophilicity, and molecular weight significantly influence a compound's ability to cross the BBB. Using artificial intelligence (AI) algorithms to predict BBB permeability, a predicted value greater than 0.75 indicates that the compound has strong potential to cross the BBB, providing a promising starting point for CNS drug discovery.

Focused and target libraries

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HY-L923 Ion Channel Lead-like Compound Library
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields. MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Focused and target libraries

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HY-L925 Cysteine Protease Focused Library
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors. This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Focused and target libraries

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HY-L927 10K Golden Scaffold Library
Designed to maximize efficiency in hit discovery and optimization, this compound library is built on a foundation of diverse Bemis-Murcko scaffolds, with each scaffold is represented by two specifically derived molecules. This strategy ensures broad chemical space through scaffold diversity while enabling preliminary functional group exploration. This approach provides early structure-activity relationship (SAR) insights for every scaffold, making it a valuable tool for accelerating drug discovery.

Distinctive Diversity Libraries

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HY-L932V Kinase Macrocyclic Compound Virtual Library
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.
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HY-L932V0 Kinase Macrocyclic Compound Virtual Library
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.

AI-enabled Libraries

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HY-L935 Molecular Glue POI binding Fragment library
POI (Protein of Interest) refers to the target protein, namely the disease-causing protein or key functional protein that undergoes degradation or functional modulation in molecular glue-mediated processes. The Molecular Glue POI Library consists of a series of fragments that can specifically bind to different types of POIs. As key components of molecular glues, these ligands form stable interactions with target proteins, laying the foundation for molecular glues to induce the interaction between POIs and E3 ubiquitin ligases. The covered POIs include various types such as cancer-associated GSPT1, androgen receptors, and abnormally aggregated proteins linked to neurodegenerative diseases. This fragment library can be applied to the screening and optimization of targeted protein degraders. By screening ligands with high affinity and strong selectivity for specific POIs from the library, core structures can be identified to develop novel molecular glues. For instance, optimization of ligands targeting GSPT1 has yielded molecular glue degraders with enhanced degradation activity. Since many POIs are difficult to drug due to the lack of traditional small-molecule binding pockets, some ligands in the POI Ligand Library can modulate such POIs by inducing protein-protein interactions, thereby further expanding the scope of drug discovery for undruggable targets. MCE has compiled a POI Fragment Library comprising thousands of POI fragments with molecular weights ranging from 150 to 400. This compound library can be widely applied in Molecular Glue research and development.

Featured Fragment Libraries

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HY-L936V0 Molecular Glue Virtual Library
Molecular Glue Virtual Library is constructed using generative AI technology, integrating the structural features, activity data of known molecular glues, and interaction information of ternary complexes (target protein-E3-molecular glue). Endowed with structural novelty, drug-likeness, diversity and synthesizability, it is applicable to molecular glue-based AI drug screening and large-scale virtual screening. MCE builds this library based on high-quality molecular building blocks by virtue of robust computing power, coupled with rigorous reaction rules and optimized compound generation strategies. To ensure library quality, molecules with high synthetic difficulty, poor drug-likeness, PAINS and other undesirable molecules are excluded first. Subsequently, scaffold-based compound analysis is performed to screen drug-like diverse molecules for synthesizability evaluation; those with excessively high synthetic difficulty are removed, ultimately forming a large-scale molecular glue virtual library with structural diversity, synthesizability and drug-likeness. Compounds in the library can be synthesized in only 1-2 chemical reaction steps. With MCE’s experienced chemical synthesis team, custom synthesis of different scales from milligram to kilogram can be easily achieved to meet diverse customer needs.

AI-enabled Libraries

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HY-L941 Allosteric Modulator Lead‑like Compound Library
Orthosteric sites are highly conserved, leading to poor subtype selectivity, off-target toxicity and drug resistance in traditional drugs. By contrast, allosteric sites show low conservation, high hydrophobicity, weak polarity, confined geometry and dynamic cryptic properties, granting modulators high selectivity, functional tunability and safety. Thus, allosteric therapy has become a major focus in drug discovery. MCE curated nearly 1,000 clinical-stage allosteric modulators, analyzed PDB complex structures to identify key pharmacophores and privileged scaffolds, then designed and filtered compounds using rational “scaffold derivation + physicochemical screening” with strict property criteria. The resulting compounds show high rigidity and shape complementarity to shallow, dynamic, hydrophobic allosteric pockets. This library comprises 4,315 diverse, lead-like compounds ideal for allosteric drug discovery and target screening, covering kinases, GPCRs and more. All are analogs of clinical-stage molecules with similarity > 0.6, combining high druggability and allosteric binding potential to support efficient early-stage R&D.

Distinctive Diversity Libraries

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HY-L942 Allosteric Modulator Fragment Library
Unlike highly conserved orthosteric sites, allosteric sites exhibit low conservation, high hydrophobicity, weak polarity, confined geometry, and dynamic cryptic properties. Rather than rigid keyhole-like cavities, they typically appear as flexible grooves, subunit interface clefts, or shallow depressions formed by protein conformational changes. Based on the dynamic, hydrophobic, and elongated nature of allosteric pockets, MCE has carried out targeted fragment modification and screening under strict physicochemical criteria: MW 120–280 Da, HBD ≤ 2, HBA ≤ 3, PSA 30–80 Ų, rotatable bonds ≤ 2, cLogP 1–3.5. High 3D diversity was further ensured by PMI analysis, yielding fragments with excellent shape complementarity to allosteric pockets. This library contains 1,800 structurally diverse, drug-like fragments, this library supports allosteric drug development and pocket optimization. It significantly improves screening hit rates and enables efficient, precise early-stage R&D of allosteric drugs.

Functional Fragment Libraries

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HY-L943 MCE‑18 Novelty drug‑like Library
MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets. This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.

Distinctive Diversity Libraries

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HY-L944 MCE‑18 Novelty Focused Drug‑Like Library
MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity. According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs. MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat

Distinctive Diversity Libraries

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HY-L947 Electrophilic Heterocyclic Fragment Library
Built on druggable heterocyclic backbones with tunable electrophilic warheads (halogens, cyano groups), our electrophilic heterocyclic fragment library targets non-conserved cysteine/lysine residues and screens covalent ligands through an electrophile-first workflow. It generates high-quality dual-functional fragments for KRAS, BTK and other popular targets, supporting MS and DEL high-throughput screening to accelerate covalent drug lead discovery. MCE Electrophilic Heterocyclic Fragment Library Built on druggable heterocyclic backbones with tunable electrophilic warheads (halogens, cyano groups), our electrophilic heterocyclic fragment library targets non-conserved cysteine/lysine residues and screens covalent ligands through an electrophile-first workflow. It generates high-quality dual-functional fragments for KRAS, BTK and other popular targets, supporting MS and DEL high-throughput screening to accelerate covalent drug lead discovery.

Functional Fragment Libraries

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HY-L948 PD-1/PD-L1 Lead-like Library
PD-1/PD-L1 are key immune checkpoint targets that suppress T-cell-mediated anti-tumor immunity, representing a major focus in cancer immunotherapy. While antibody drugs dominate the clinic, they are limited by administration challenges and immune-related side effects. Small-molecule PD-1/PD-L1 inhibitors, with oral availability, good tissue penetration and low cost, have emerged as a promising next-generation strategy. A PD-1/PD-L1 lead-like library was built via a five-step virtual screening process. After collecting 8,947 inhibitors from BindingDB and PubChem and filtering by activity and duplicates, AI similarity screening was performed using GeminiMol. Key pharmacophores were extracted from the PPI interface of co-crystal structures, and molecular was screened via a pharmacophore model, effectively enhancing target activity. Containing 10,000 structurally diverse and drug-like molecules well-matched to the PD-L1 pocket, the library supports virtual docking, high-throughput screening and hit discovery, enabling efficient and rapid development of small-molecule immunotherapies.

Focused and target libraries

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HY-LD002 DEL B Kit Regular Library
The discovery of hit molecule is a cornerstone of drug development. Among the diverse tools available, DNA-encoded libraries have emerged a revolutionary platform for high-throughput screening. Compared with traditional HTS, DEL features shorter screening processes, lower costs, simpler assays, and larger library capacities. DEL Construction utilizes split-and-pool synthesis, a combinatorial chemistry approach that involves iterative splitting, reaction, and pooling. This strategy enables rapid, exponential assembly of fragments in minimal steps without the need for individual compound synthesis andassoicicated isolation or purification steps, thus greatly reducing overall costs. The technology enables simultaneous affinity screeningof massive compound collections to target proteins in a single step. By coupling chemical structures with unique DNA barcodes, each compound is tagged with a distinct DNA sequence for convenient tracking and decoding.DELs readily enable the construction and efficient screening of libraries containing millions to billions of compounds. As a result, DEL screening combines the dual advantages of high efficiency and low cost, making DEL a transformative technology in modern drug discovery. The DEL kit consists of 50 independent libraries with a total scale of 100 billion compounds. It is constructed through stepwise combinatorial chemistry strategies involving 2-, 3-, and 4-round synthesis. By employing diverse scaffolds and flexible linking strategies, it encompasses various ring systems, linear frameworks, and heterocyclic structures. Screening can be achieved solely through affinity, independent of target-specific activity detection methods. This library is suitable for DEL screening against a wide range of targets.

DNA Encoded Libraries

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HY-LD004 DEL Covalent Library
DEL technology enables the simultaneous screening of millions or billions of compounds in a single tube by covalently linking each small molecule with a unique DNA sequence. Traditional DEL screening primarily focuses on identifying non-covalent binding molecules, where interactions with the target are reversible. In contrast, DNA‑encoded covalent library is an ultra‑high‑throughput screening library developed on the basis of conventional DNA‑encoded library technology. It incorporates controllable electrophilic covalent warheads capable of forming irreversible covalent bonds with amino acid residues at the active sites of target proteins, including Cys, Lys, Ser, Tyr, and others. This covalent binding enhances binding affinity, prolongs residence time at the target site, and has the potential to overcome challenges associated with traditional non-covalent inhibitors, such as drug resistance or off-target effects. Each compound in the library contains both a binding domain and an electrophilic warhead. It first recognizes and binds to the target through non covalent interactions, and then forms a stable covalent bond with key amino acid residues to achieve irreversible inhibition. This library is specifically designed for the discovery of potent, long lasting, and highly selective covalent inhibitors, particularly for undruggable targets such as kinases, GPCRs, proteases, and mutant oncoproteins. Each molecule is uniquely labeled with a DNA barcode for molecular identification and sequencing decoding. This library is an advanced and highly diverse collection, consists of 35 independent sub-libraries with a total scaleof 14 million compounds, It incorporates over 14 experimentally validated covalent warheads capable of targeting cysteine, lysine, arginine, aspartic acid and glutamic acid. This library is constructed with diverse drug like core scaffolds and integrated controllable covalent warheads, it features structural diversity, reaction spec

DNA Encoded Libraries

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HY-LD005 DEL D Kit Cyclic Peptide Library
Cyclic peptide library have advantages such as high affinity, high selectivity, and suitability for targeting protein–protein interactions. Through DEL synthesis technology, the library size can achieve hundreds of millions. DEL cyclic peptide library have advantages like low cost andhigh screeing efficiency, making them valuable for discovering lead compounds against challenging drug targets. This cyclic peptide library is constructed with unnatural amino acids as building block, synthesized through DNA-compatible chemical reactions. Each cyclic peptide consist of six amino acids and constrained conformations such as side-chain cross-linking, disulfide bonds, and macrocyclization. These cyclic peptides exhibit significantly improved stability and druggability compared with linear peptides, filling the gap between small molecules and macromolecular biologics. Each cyclic peptide is uniquely conjugated to a DNA barcode sequence for molecular identification and sequencing decoding. MCE’s cyclic peptide library has8 independent sub-libraries, with a total molecular diversity of 1.2 billion. It is constructed via multi-round combinatorial assembly of building blocks and diverse cyclization strategies, facilitating the discovery of cyclic peptide leads for undruggable targets.

DNA Encoded Libraries

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HY-N0293 Paeoniflorin
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.
HSP  
Cancer   Infection   Parkinson's Disease  
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HY-16637A Folic acid sodium
Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
DNA/RNA Synthesis   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
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HY-W105700 Ethylenediaminetetraacetic acid sodium hydrate
Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research.
Biochemical Assay Reagents   Bacterial   SOD  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
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HY-W127774 EDTA hydrate sodium
EDTA (Ethylenediaminetetraacetic acid) hydrate sodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). EDTA hydrate sodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. EDTA hydrate sodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA hydrate sodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.
Biochemical Assay Reagents   SOD   Bacterial  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
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HY-16637 Folic acid
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
Environmental Pollutants   DNA/RNA Synthesis   Endogenous Metabolite  
Cancer   Depression   Blood Disease   SARS-CoV-2 Infection  
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HY-17591 Penicillin G potassium
Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas.

Source: Penicillium

Antibiotic   Bacterial  
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HY-B0633A Hyaluronic acid
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer.
Endogenous Metabolite   Bacterial   Akt   PI3K  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   SARS-CoV-2 Infection  
21
HY-B1610H Sodium citrate dihydrate, United States Pharmacopeia (USP) Reference Standard
Sodium citrate (Trisodium citrate) dihydrate, United States Pharmacopeia (USP) Reference Standard is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer.
Apoptosis   Bacterial  
Gastric Cancer   Bacterial Infection   Antioxidant Agent   Glycolysis  
13
HY-D0973 EGTA-AM
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca2+ chelator with slow chelating dynamics.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
11
HY-P1411A Psalmotoxin 1 TFA
Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease.
Sodium Channel   Apoptosis  
Neurological, Eye or Ear Disease  
7
HY-P1411 Psalmotoxin 1
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease.
Sodium Channel   Apoptosis  
Neurological, Eye or Ear Disease  
7
HY-101884 Biocytin
Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
7
HY-W250978 Ovalbumins
Ovalbumins are the major proteins in egg white. Ovalbumins act as an allergen and inducer, and can be applied to mouse models of allergic diseases. Ovalbumins can induce allergic rhinitis in mice via sensitization and nasal challenge. Ovalbumins can be used to establish asthma models.
Ovalbumin, low endotoxin (HY-W250978A) is recommended for model establishment.
Interleukin Related   IFNAR  
Allergic Asthma   Allergic Rhinitis  
6
HY-N6953 Garcinone D
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer.
STAT   Keap1-Nrf2   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Lung Cancer   Breast Cancer   Pancreatic Cancer   Obesity   Lung Fibrosis  
5
HY-N2183 Baimaside
Baimaside (Quercetin 3-O-sophoroside) is a flavonoid cholinergic function modulator that binds to SARS-CoV-2-related targets. Baimaside regulates the expression of cholinergic system-related proteins and acetylcholine levels, improves scopolamine-induced learning and memory impairment, protects hippocampal neurons, inhibits pollen protein fluorescence, and protects pollen DNA. Its biosynthesis is regulated by multiple enzymes. Baimaside is completely absorbed in rats, undergoes phase Ⅱ metabolism and gut microbiota decomposition, and inhibits the invasion and proliferation of SARS-CoV-2 and its variants, making it suitable for research related to Alzheimer's disease and COVID-19.
SARS-CoV  
SARS-CoV-2 Infection   Alzheimer's Disease  
5
HY-113216 Asymmetric dimethylarginine
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.
Endogenous Metabolite   NO Synthase  
Breast Cancer   Viral Infection  
5
HY-Y0344H Sodium chloride, United States Pharmacopeia (USP) Reference Standard
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells.
Biochemical Assay Reagents   Na+/K+ ATPase   Interleukin Related  
Autoimmune Disease   Small Cell Lung Cancer  
3
HY-N4288 4-Methylesculetin
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases.
Glutathione Peroxidase   Cathepsin   Phosphatase  
Inflammation or Immune System Disease   Prostate Cancer   Ovarian Cancer   Depression   Pain  
3
HY-114495 Caerulomycin A
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma.

Source: Streptomyces caeruleus

Fungal   Antibiotic  
Fungal Infection   Asthma   Rheumatoid Arthritis  
3
HY-D2346 HBmito Crimson
HBmito Crimson is a deep red fluorescent probe (λex: 658 nm, λem: 678 nm) for the inner mitochondrial membrane. HBmito Crimson is a cell membrane-permeable probe with high selectivity for the mitochondrial inner membrane, suitable for specific fluorescence staining of the inner mitochondrial membrane in living cells. HBmito Crimson has high photostability and brightness, suitable for long-term dynamic fluorescence imaging.
Fluorescent Dye  
3
HY-N2016 Arteannuin B
Arteannuin B, No. 2000 can be jointly submitted with the blue material. Arteannuin B had anti-SARS-CoV-2 activity, EC50=10.28 μM.
SARS-CoV   Ferroptosis  
Viral Infection  
3
HY-D2119 CQ-Lyso
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes.
Fluorescent Dye  
Cancer  
3
HY-108910 Chymotrypsin
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration.
Toll-like Receptor (TLR)   NF-κB   MMP  
Breast Cancer   Digestive System Inflammation   Gastric Disease   Metastatic Melanoma   Pharyngitis   Rheumatoid Arthritis  
3
HY-Y0406E Calcium chloride anhydrous, for cell culture
Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers. Calcium chloride anhydrous, for cell culture can be used for animal modeling, to construct abdominal aortic aneurysm models.
Environmental Pollutants   Biochemical Assay Reagents  
Lung Cancer   Breast Cancer   Staphylococcus Aureus Infection  
3
HY-K0225 Carboxyl Magnetic Beads (200 nm, 10 mg/mL)

MCE Carboxyl Magnetic beads (200 nm, 10 mg/mL) are characterized by superparamagnetism, fast magnetic response, abundant carboxyl functional groups, monodispersity, and submicron scale particle size. Biological ligands (proteins, peptides, oligonucleotides, drug molecules, etc.) can be covalently coupled to the surface of microspheres under the action of special chemical reagents (such as EDC).

Protein Biology Protein Purification Magnetic Beads

3
HY-D1868 Cy3 azide plus
Cy3 azide plus is a Cyanine 3 (Cy3) (HY-D0822) dye derivative with an azide functional group. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The azide group of Cy3 azide plus can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Cy3 azide plus can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
2
HY-N11287 UDP-xylose
UDP-xylose is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose synthase (UXS). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].

Source: Cryptococcus laurentii (N RRL Y-1401)

Endogenous Metabolite  
2
HY-P10136A IA9 TFA
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research.
TREM receptor  
Rheumatoid Arthritis  
2
HY-N0584 Anisodamine
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning.
mAChR  
Cancer   Parkinson's Disease  
2
HY-N11287A UDP-xylose disodium
UDP-xylose disodium is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose disodium synthase (UXS). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose disodium participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].
Endogenous Metabolite  
2
HY-P99288 FG-3019
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF).

Species: Human

Apoptosis  
Lung Fibrosis  
2
HY-P10136 IA9
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research.
TREM receptor  
Rheumatoid Arthritis  
2
HY-B0141R Estradiol (Standard)
Estradiol (Standard) is the analytical standard of Estradiol. This product is intended for research and analytical applications. Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering.
Reference Standards   Estrogen Receptor/ERR   Endogenous Metabolite   Bacterial  
Metabolic or Endocrine Disease   Metastatic Breast Cancer  
2
HY-P80761 N Cadherin Antibody (YA276)
N Cadherin Antibody (YA276) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to N Cadherin.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

2
HY-K6008 Basement Membrane Matrix HC

MCE High-Concentration Basement Membrane Matrix (Phenol Red-Free) is primarily composed of natural basement membrane matrix extracted from mouse tumors. It is rich in extracellular matrix components and various naturally occurring growth factors, and is mainly used for the establishment of animal models and 3D tumor models.

Cell Biology 3D Cell Culture Basement Membrane Matrix

2
HY-P2203A SAHM1 TFA
SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly.
Notch  
Cancer  
1
HY-Y1325E Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard
Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard (Sodium acetate trihydrate (Pharmaceutical primary standard, USP)) is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain.
Environmental Pollutants   Caspase   Reactive Oxygen Species (ROS)   Endogenous Metabolite   AMPK   Fungal   PPAR  
Gastric Cancer   Pain   Liver Disease   Colitis  
1
HY-N2183R Baimaside (Standard)
Baimaside (Standard) is the analytical standard of Baimaside. This product is intended for research and analytical applications. Baimaside (Quercetin 3-O-sophoroside) is a flavonoid cholinergic function modulator that binds to SARS-CoV-2-related targets. Baimaside regulates the expression of cholinergic system-related proteins and acetylcholine levels, improves scopolamine-induced learning and memory impairment, protects hippocampal neurons, inhibits pollen protein fluorescence, and protects pollen DNA. Its biosynthesis is regulated by multiple enzymes. Baimaside is completely absorbed in rats, undergoes phase Ⅱ metabolism and gut microbiota decomposition, and inhibits the invasion and proliferation of SARS-CoV-2 and its variants, making it suitable for research related to Alzheimer's disease and COVID-19.
Reference Standards   SARS-CoV  
1
HY-106150 Eniporide
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
Na+/H+ Exchanger (NHE)  
1
HY-P3532 [Glp1]-FGL peptide acetate
[Glp1]-FGL peptide acetate is a neural cell adhesion molecule (NCAM) derived motif and can be used for the research of neurogenesis.
Others  
Neurological, Eye or Ear Disease  
1
HY-N0459 3,5-O-Dicaffeoylquinic acid
3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits.
Others  
Neurological, Eye or Ear Disease  
1
HY-113845 (+)-Intermedine
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
Others  
Neurological, Eye or Ear Disease  
1
HY-17591R Penicillin G potassium (Standard)
Penicillin G (potassium) (Standard) is the analytical standard of Penicillin G (potassium). This product is intended for research and analytical applications. Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas.
Reference Standards   Antibiotic   Bacterial  
Bacterial Infection  
1
HY-P0204 Endothelin-3, human, mouse, rabbit, rat
Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis.
Endothelin Receptor   Integrin  
Neurological, Eye or Ear Disease  
1
HY-P99216 Ponezumab
Ponezumab (PF-04360365; RN 1219) is a humanized anti-amyloid-β (Amyloid-β) IgG2 monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves the performance of mice in various learning and memory models. Ponezumab is applicable to the research of Alzheimer's disease.

Species: Human

Amyloid-β  
Alzheimer's Disease  
1
HY-107198 (2S)-6-Prenylnaringenin
(2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin acts as a GABAA positive allosteric modulator at α+β- binding interface.
GABA Receptor  
Depression   Alzheimer's Disease   Parkinson's Disease  
1
HY-W040230 Acrylodan
Acrylodan, reacted with thiols, is sensitive to the local environmental dipolarity and dynamics within the binding pocket surrounding Cys34.
Fluorescent Dye  
1
HY-N0723 Neomangiferin
Neomangiferin is an orally active natural flavonoid. Neomangiferin partially ameliorates non-alcoholic fatty liver disease (NAFLD) by regulating the expression of genes related to free fatty acid uptake and lipid oxidation. Neomangiferin exerts anti-colitis effects by inhibiting Th17/Treg cell differentiation. Neomangiferin exerts anti-aging and lifespan-extending effects by targeting upregulation of bas-1, which in turn activates the autophagy, IIS and MAPK pathways. Neomangiferin has the potential to prevent aseptic loosening of prostheses after total joint arthroplasty due to its significant anti-inflammatory and osteoclastogenesis-inhibiting effects.
Autophagy   p38 MAPK   TNF Receptor   Interleukin Related   PPAR  
Digestive System Disease   Colitis   Fatty Liver Disease   Osteoporosis  
1
HY-125098 Illudin S
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells.

Source: Lampteromyces japonicus

DNA Alkylator/Crosslinker   Apoptosis  
Cancer   Infection  
1
HY-Y1117 Melamine
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models.
Drug Metabolite   NADPH Oxidase   TGF-β Receptor   COX   ROS Kinase   Apoptosis   NF-κB  
Bladder Cancer   Renal Disease   Male Reproductive System Disease   Alzheimer's Disease  
1
HY-W011370 Pelargonidin chloride
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment.
Quinone Reductase   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
1
HY-13716 Noscapine
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier.
Opioid Receptor   Apoptosis  
Cancer   Digestive System Disease   Depression   Pain   Digestive System Inflammation  
1
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis.
Endothelin Receptor   Integrin  
Neurological, Eye or Ear Disease  
1
HY-113061 Pseudouridine
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia..
Endogenous Metabolite   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
Lung Cancer   Leukemia/Lymphoma/Myeloma  
1
HY-D0896 ANS
ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (Ki=2.09×106 M-1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development.
Free Radical Scavengers   Bacterial  
Staphylococcus Aureus Infection  
1
HY-P70347 Collagen alpha-1(XVIII) chain/COL18A1 Protein, Mouse (HEK293, His)
The COL18A1 protein may play a key role in shaping retinal structure and promoting neural tube closure. Its involvement extends to the regulation of extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells. Collagen alpha-1 (XVIII) chain/COL18A1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Collagen alpha-1(XVIII) chain/COL18A1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

1
HY-P7009 Collagen Alpha-1(XVIII) Chain/Endostatin Protein, Human (P.pastoris)
Endostatin Protein, Human (P.pastoris) is an endogenous antiangiogenic peptide with multiple antitumor roles through modulation of various receptors in the plasma membrane, such as suppression of angiogenesis and inhibition of tumor-cell migration and invasion.

Species: Human; Source: P. pastoris

1
HY-P73749 NCAM-1/CD56 Protein, Rat (HEK293, His)
The NCAM-1/CD56 protein is a key cell adhesion molecule that plays a key role in neuron-neuron adhesion, neurite fasciculation, and neurite outgrowth.Its interaction with MDK contributes to complex cellular interactions in neural development.NCAM-1/CD56 Protein, Rat (HEK293, His) is the recombinant rat-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-His labeled tag.

Species: Rat; Source: HEK293

CD Antigens NK Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins NCAM-1/CD56

1
HY-K6005 Basement Membrane Matrix HC (Phenol Red)

MCE Basement Membrane Matrix HC (High Concentration, Phenol Red) is primarily composed of natural basement membrane matrix extracted from mouse tumorsand contains abundant extracellular matrix components and a variety of naturally occurring growth factors. This product is mainly used for angiogenesis experiments, construction of animal models and 3D tumor models.

Cell Biology 3D Cell Culture Basement Membrane Matrix

1
HY-K6010 Tissue Storage Solution

MCE Tissue Storage Solution is designed for the short-term storage or transportation of primary tissue samples. It effectively prevents cell apoptosis, necrosis, and other detrimental processes during storage or transport, thereby preserving the functionality and vitality of stem cells.

Cell Biology 3D Cell Culture Organoid Research

1
HY-P99578 Tanfanercept
Tanfanercept (HL036337) is an TNF-α receptor fusion protein that targets TNF-α. Tanfanercept is effective in ameliorating corneal erosions in a dry eye (DE) mouse model.
TNF Receptor  
Inflammation or Immune System Disease  
/
HY-P10259 BNP(1-32), porcine
BNP(1-32), porcine (pBNP-32) is a cardiac hormone. BNP(1-32), porcine is an atrial natriuretic peptide, which exhibits natriuretic, diuretic and vasorelaxant effects. BNP(1-32), porcine affects passive avoidance learning in rats with dopaminergic, cholinergic, α-and β-adrenergic mediation.
Natriuretic Peptide Receptor (NPR)  
Neurological, Eye or Ear Disease  
/
HY-D1317A Cyanine7.5 carboxylic
Cyanine7.5 carboxylic is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid functional groups. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Cyanine7.5 carboxylic can be covalently bound to some biological molecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-111964S1 Lenacapavir-d5
Lenacapavir-d5 (GS-6207-d5) is the deuterium labeled Lenacapavir (HY-111964). Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection.
Isotope-Labeled Compounds   HIV  
Infection  
/
HY-N0283S Diacerein-d6
Diacerein-d6 is the deuterium labeled Diacerein. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.
Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P10663 EBV EBNA3A (379-387)
EBV EBNA3A (379-387) is an antigenic epitope that may elicit the latent-specific CD8+ T cell response in HLA-B*07:02+ individuals.
EBV  
Infection   Inflammation or Immune System Disease  
/
HY-D1860 Cy3 alkyne chloride
Cy3 alkyne chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing a sulfonate ion and an alkyne functional group. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 alkyne chloride can react with molecules containing the azide functional group to form covalent bonds. Cy3 alkyne chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-133091S 7-Ethoxycoumarin-d5
7-Ethoxycoumarin-d5 is deuterium labeled 7-Ethoxycoumarin. 7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs.
Cytochrome P450   Isotope-Labeled Compounds  
/
HY-NP229 DNP-BSA
DNP-BSA is a multivalent antigen and protein-binding reagent. DNP-BSA binds to subdomain IIA (Site I) of bovine serum albumin via predominantly hydrophobic forces, with spontaneous complex formation via combined dynamic and static quenching. DNP-BSA induces cross-linking of IgE-bound FceRI, triggering tyrosine phosphorylation of FceRI β and γ subunits. DNP-BSA binds to anti-DNP IgE via its DNP groups, forming cross-links between IgE-FceRI complexes, with most DNP groups initially unavailable but transiently exposed for binding. DNP-BSA induces FITC fluorescence quenching in FITC-labeled anti-DNP IgE, proportional to occupied IgE Fab binding sites. DNP-BSA can be used for the research of allergy, inflammation, and contact sensitivity (allergic contact dermatitis).
Biochemical Assay Reagents  
Allergy  
/
HY-119447S Mavacoxib-d4
Mavacoxib-d4 is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs.
Isotope-Labeled Compounds   COX  
Inflammation or Immune System Disease  
/
HY-167855S 1’-Epi Gemcitabine hydrochloride-13C,15N2
1’-Epi Gemcitabine hydrochloride-13C,15N2 is the 13C- and 15N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
Isotope-Labeled Compounds   P2Y Receptor  
Inflammation or Immune System Disease  
/
HY-D2279 NFL-NH2
NFL-NH2 is a mitochondrial-targeted near-infrared ratiometric fluorescent probe. NFL-NH2 can rapidly detect NO levels associated with the inflammatory damage degree in rheumatoid arthritis (RA) mice models by ratiometric fluorescence imaging. The excitation wavelength and emission wavelength are 650 nm and 780 nm, respectively.
Fluorescent Dye  
Inflammation or Immune System Disease  
/
HY-178425S Butylhydroxyanisole-d24
Butylhydroxyanisole-d24 (Butylated hydroxyanisole-d24) is the deuterium labeled Butylhydroxyanisole (HY-B1066). Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development. Butylhydroxyanisole is a ferroptosis inducer.
Isotope-Labeled Compounds   Reactive Oxygen Species (ROS)   Ferroptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-N9972 Panaxcerol C
Panaxcerol C (1,2-Di-O-α-linolenoyl-3-O-β-galactopyranosyl-sn-glycerol) is a plant galactolipidwith anti-inflammatory activity. It protects animals from septic shock by regulating the dynamic of oxidized lipid mediators through the MAPK-cPLA2 signaling pathway.
p38 MAPK  
/
HY-123320S Fluvalinate-d5
Fluvalinate-d5 is the deuterated-labeled Fluvalinate (HY-123320). Fluvalinate is an orally active acaricide classified as a sodium channel inhibitor. Fluvalinate delays sodium channel closure, prolongs cell membrane depolarization, inhibits the excitability of honeybee brain neurons, and exerts a central nervous system inhibitory effect. Fluvalinate negatively affects the learning ability, memory ability, sucrose responsiveness, and survival of honeybees. Fluvalinate potentiates pentobarbital-induced hypnosis, reduces spontaneous activity in mice, and decreases the total white blood cell count and absolute lymphocyte count in mice. Fluvalinate induces acute toxic symptoms in rats, acts as a cholinergic stimulant, and induces the production of hepatic enzymes in rats. Fluvalinate causes the death of Varroa jacobsoni sensitive to τ-Fluvalinate (HY-B2021). Fluvalinate can be used in studies related to mite pest control.
Isotope-Labeled Compounds   Insecticide   Sodium Channel  
Neurological, Eye or Ear Disease   Insecticide  
/
HY-P5859 α-Pompilidotoxin
α-Pompilidotoxin (α-PMTX) is a neurotoxin that can be obtained from the venom of Anoplius safnariensis. α-Pompilidotoxin reversibly and dose-dependently enhances excitatory postsynaptic currents (EPSCs). α-Pompilidotoxin is a useful tool in the field of neuroscience research.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-13716R Noscapine (Standard)
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier[4].
Reference Standards   Opioid Receptor   Apoptosis  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P4096A Cys-HAP-1
Cys-HAP-1 is a synovium-homing peptide that specifically binds to human and rabbit fibroblast-like synoviocytes, and does not bind to human umbilical vein endothelial cells regardless of TNF-α treatment. Cys-HAP-1 enables targeted drug delivery to inflamed joints after conjugation with liposomes loaded with anti-arthritic agents. Cys-HAP-1 can be used in studies related to adjuvant arthritis.
Others  
Inflammation or Immune System Disease   Arthritis  
/
HY-W768571 Pseudouridine-13C,15N2
Pseudouridine-13C,15N2 is the 13C- and 15N-labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia..
Isotope-Labeled Compounds   Endogenous Metabolite   DNA/RNA Synthesis   Nucleoside Antimetabolite/Analog  
Cancer  
/
HY-P992230 Anti-Galanin Antibody
Anti-Galanin Antibody is a monoclonal antibody that targets galanin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-Galanin Antibody, please refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Species: Human

Neuropeptide Y Receptor  
Inflammation or Immune System Disease  
/
HY-W284558S Sodium hexadecyl sulfate-d33
Sodium hexadecyl sulfate-d33 is the deuterium labeled Sodium hexadecyl sulfate. Sodium hexadecyl sulfate is a long-chain anionic surfactant. Sodium hexadecyl sulfate can act as an interface-regulating substance to form a soft layer on the surface of carbon nanotubes, guide proteins to adsorb in the correct orientation with active sites facing outward through electrostatic interactions, and significantly enhance the activity of immobilized enzymes. Sodium hexadecyl sulfate can replace or supplement SDS (HY-Y0316) in capillary gel electrophoresis (CGE).
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-P1176 NTR 368
NTR 368 is a peptide derived from p75 neurotrophin receptor (p75NTR) corresponding to residues 368-381 of the human receptor. NTR 368 has helix forming propensity in the presence of micellar lipid. NTR 368 is a potent inducer of neural apoptosis.
Apoptosis  
Neurological, Eye or Ear Disease  
/
HY-N20637 Polygalasaponin XXXII
Polygalasaponin XXXII is an orally active cognitive enhancer. Polygalasaponin XXXII promotes the phosphorylation of ERK, CREB, Synapsin I and TrkB. Polygalasaponin XXXII enhances basal synaptic transmission. Polygalasaponin XXXII attenuates Scopolamine (HY-N0296)-induced cognitive impairment and improves hippocampus-dependent learning and memory abilities. Polygalasaponin XXXII can be used in research related to cognitive dysfunction.
ERK   Epigenetic Reader Domain   Trk Receptor  
Alzheimer's Disease  
/
HY-130921 Sulfo-Cyanine7 carboxylic acid potassium
Sulfo-Cyanine7 carboxylic acid potassium is a near-infrared fluorescent dye. Sulfo-Cyanine7 carboxylic acid potassium is applicable to ex vivo histological imaging of the trigeminal nerve in rats as well as studies on the distribution and retention in brain tissues. Sulfo-Cyanine7 carboxylic acid potassium can serve as a model hydrophilic probe for multiplex biomedical fluorescence imaging (Ex=750 nm, Em=773 nm).
Fluorescent Dye  
/
HY-D0234 o-Cresolphthalein
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
Endogenous Metabolite  
/
HY-15037S Diclofenac-13C6 sodium heminonahydrate
Diclofenac-13C6 (sodium heminonahydrate) is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
Isotope-Labeled Compounds   COX   Apoptosis  
Inflammation or Immune System Disease  
/
HY-P99881 Rolinsatamab talirine
Rolinsatamab talirine (ABBV 176) is a prolactin receptor (PRLR)-targeting antibody-drug conjugate (ADC), compoused of Rolinsatamab (HY-P99238) and SGD-1882 (HY-101127). Rolinsatamab talirine binds to PRLR to deliver a cytotoxin to tumor cells. Rolinsatamab talirine induces DNA damage, and exhibits cytotoxicity against multiple breast tumor models, including triple negative and low PRLR-expressing models. Rolinsatamab talirine demonstrates enhanced anti-tumor activity in several breast cancer models. Rolinsatamab talirine can be used for the research of breast cancer, hepatocellular carcinoma, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, adrenocortical carcinoma, and solid tumors.
Antibody-Drug Conjugates (ADCs)  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Ovarian Cancer  
/
HY-P2446 ORG 30276
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
GnRH Receptor  
Metabolic or Endocrine Disease  
/
HY-D2990 KSA01
KSA01 is a two-dimensional fluorescent probe. KSA01 can detect SA-β-gal activity and sense lysosomal pH. KSA01 can accurately distinguish cellular aging from other pathological states with high expression of β-gal.
Fluorescent Dye  
/
HY-Y0332J Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard
Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard (Potassium phosphate monobasic (Pharmaceutical primary standard, USP)) is a potassium salt. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard activates NF-κB. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard upregulates the expression of dental/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) and enhances the mineralization capacity of human periodontal ligament stem cells. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard promotes the proliferation of human periodontal ligament stem cells in logarithmic growth phase. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard promotes the growth of somatic embryos of Dendrobium Sonia, increases leaf number, leaf length and fresh weight of tissue-cultured seedlings. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard is applicable to periodontal disease-related research.
Biochemical Assay Reagents   NF-κB   RUNX   Phosphatase  
Osteogenic Differentiation  
/
HY-P10675 Peptide K
Peptide K is a self-assembling peptide fiber that can be used to prepare fibrous nanocomposite hydrogels. The fibrous nanocomposite hydrogels have a dynamic network that adapts to cells and enhances cell-matrix and cell-cell interactions, thus significantly promoting the mechanotransduction, metabolic energy, and osteogenesis of encapsulated stem cells.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-163287 QPy-TPA
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm.
Fluorescent Dye  
/
HY-P1685 Ranatensin
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212),Bradykinin (HY-P0206), or Norepinephrine (HY-13715).
Bombesin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W663542 Nimolicinol
Nimolicinol is a tetranortriterpenoid compound. Nimolicinol binds to the ephrinB2 interaction interface of the Nipah virus attachment glycoprotein, interfering with virus-host cell adhesion, and exhibits anti-Plasmodium, anti-SARS-CoV-2, and larvicidal activities. Nimolicinol can be used in research on Nipah virus infection, malaria, COVID-19, and filariasis.
Parasite   SARS-CoV  
SARS-CoV-2 Infection   Plasmodium Infection  
/
HY-101884R Biocytin (Standard)
Biocytin (Standard) is the analytical standard of Biocytin. This product is intended for research and analytical applications. Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays[1][2].
Reference Standards   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-D2967 Golgi-NO
Golgi-NO is a Golgi-targeted fluorescent probe for nitric oxide (NO) (Ex/Em: 560 nm/589 nm). Golgi-NO exhibits excellent selectivity for various potential interfering substances. Golgi-NO can be used to study the function of NO within the Golgi apparatus in disease models such as Alzheimer's disease (AD).
Fluorescent Dye  
Alzheimer's Disease  
/
HY-Y0319C1 Calcium acetate, United States Pharmacopeia (USP) Reference Standard
Calcium acetate, United States Pharmacopeia (USP) Reference Standard (Calcium acetate (Pharmaceutical primary standard, USP)), a phosphate binder that can reduce phosphorus content, United States Pharmacopeia (USP) reference standard.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-Y0537I Potassium chloride, United States Pharmacopeia (USP) Reference Standard
Potassium chloride, United States Pharmacopeia (USP) Reference Standard is an inorganic salt, which can be used for the buffer preparation.
Biochemical Assay Reagents  
/
HY-113061S Pseudouridine-O18
Pseudouridine-18O is the 18O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
Isotope-Labeled Compounds   Endogenous Metabolite   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
/
HY-P11626 Cyclo(Ala-Hyp)
Cyclo(Ala-Hyp) is an orally effective collagen-derived hydroxyproline-containing cyclic dipeptide that can be isolated from the culture supernatant of Lactobacillus plantarum. Cyclo(Ala-Hyp) has an AUC0-6h of 2.350 μg/mL·h, significantly higher than traditional collagen oligopeptides. Cyclo(Ala-Hyp) can be used in research related to liver and kidney function protection, skin care, and joint health.
Collagen  
Metabolic or Endocrine Disease  
/
HY-A0300 Cyclopeptide-5
Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects.
Integrin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P3712 Cardioexcitatory peptide 1
Cardioexcitatory peptide 1 is a cardioexcitatory neuropeptide, can be isolated from Achatina atria. Cardioexcitatory peptide 1 has potent cardio-excitatory action on the hearts and also modifies the motility of muscular tissues and neural activities.
Others  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-183217C Dextran-Biotin (MW 100 kDa)
Dextran-Biotin (MW 100 kDa) is a functional material formed by covalently linking biotin to dextran molecules. Dextran-Biotin combines the biocompatibility of dextran with the high affinity of biotin for streptavidin, and is widely used in research fields such as biolabeling, detection, drug delivery, and neural tracking.
Biochemical Assay Reagents  
/
HY-D3499 (E,E)-3,5-Bis(phenylethenyl)-BODIPY lipid stain
(E,E)-3,5-Bis(phenylethenyl)-BODIPY lipid stain is a fluorescent dye for intracellular lipid droplets. It is primarily used for specific fluorescent labeling and dynamic tracking of lipid droplets in living or fixed cells (Ex/Em = 627 nm/640 nm).
Fluorescent Dye  
/
HY-D1862 Cy7.5 alkyne chloride
Cy7.5 alkyne chloride is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) containing a sulfonate ion and an alkyne functional group. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The alkyne functional group of Cy7.5 alkyne chloride can react with molecules containing the azide functional group to form covalent bonds. Cy7.5 alkyne chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-W748758 (Z)-Thiothixene-d8
(Z)-Thiothixene-d8 (NSC 108165-d8; Navan-d8; Navane-d8) is the deuterium labeled Thiothixene (HY-A0139). Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.
Isotope-Labeled Compounds   mAChR   Histamine Receptor   Sigma Receptor   Dopamine Receptor   Adrenergic Receptor  
/
HY-183217E Dextran-Biotin (MW 500 kDa)
Dextran-Biotin (MW 500 kDa) is a functional material formed by covalently linking biotin to dextran molecules. Dextran-Biotin combines the biocompatibility of dextran with the high affinity of biotin for streptavidin, and is widely used in research fields such as biolabeling, detection, drug delivery, and neural tracking.
Biochemical Assay Reagents  
/
HY-183217D Dextran-Biotin (MW 250 kDa)
Dextran-Biotin (MW 250 kDa) is a functional material formed by covalently linking biotin to dextran molecules. Dextran-Biotin combines the biocompatibility of dextran with the high affinity of biotin for streptavidin, and is widely used in research fields such as biolabeling, detection, drug delivery, and neural tracking.
Biochemical Assay Reagents  
/
HY-10224S Panobinostat-d4
Panobinostat-d4 is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
HDAC   Autophagy   HIV   Apoptosis  
Cancer  
/
HY-D3005 NpCy-4
NpCy-4 is a reliable reporter for monitoring lysosomal pH and viscosity changes in real time during Autophagy (λex = 650 nm; λem = 660-740 nm). NpCy-4 demonstrates a superior signal-to-background ratio (SBR) for cellular imaging. NpCy-4 facilitates real-time, noninvasive diagnostic imaging of acute gastritis model with high contrast.
Fluorescent Dye   Autophagy  
Gastric Disease  
/
HY-N0949 (-)-Variabilin
(-)-Variabilin (compound 13) is an Neurogenin2 (Ngn2) promoter activator isolated from Butea superba. (-)-Variabilin promotes differentiation of neural stem cells into neurons.
Others  
Neurological, Eye or Ear Disease  
/
HY-P992387 INA01
INA01 is an unlabeled human monoclonal antibody targeting CD71/TFRC, which can be used in ELISA, FACS and functional assays. INA01 is promising for leukemia-related research.

Species: Human

Transferrin Receptor  
Leukemia/Lymphoma/Myeloma  
/
HY-126778 Vinrosidine
Vinrosidine (Leurosidine) is a mitotic spindle microtubule inhibitor with antitumor activity. Vinrosidine regulates tubulin dynamics at microtubule plus ends, disrupts mitotic spindle function, and blocks cell cycle progression at metaphase. Vinrosidine exhibits antitumor activity in multiple in vivo xenograft models. Vinrosidine can be used in cancer-related research.
Microtubule/Tubulin  
Cancer  
/
HY-P4096C Cys-scHAP-1
Cys-scHAP-1 is an N-terminal cysteine-labeled disordered peptide of HAP-1. Cys-scHAP-1 can be used to construct scHAP-1-targeted liposomes, which bind to human and rabbit fibroblast-like synoviocytes and localize to inflamed joints in vivo in a rat adjuvant-induced arthritis model. Cys-scHAP-1 is applicable to arthritis research.
Others  
Inflammation or Immune System Disease   Arthritis  
/
HY-D2062 ATTO 740 NHS ester
ATTO 740 NHS ester is a near-infrared fluorescent dye and a multimodal fluorescence/photoacoustic contrast agent with excellent near-infrared emission properties and extremely high photostability. The photoacoustic signal of ATTO 740 NHS ester shows no significant decrease after continuous irradiation with a 750 nm laser for 30 min, making it suitable for in vivo fluorescence imaging and photoacoustic contrast imaging. When conjugated with the cystine knot peptide R01, ATTO 740 NHS ester enables precise detection of integrin αvβ6-positive cells and tumors in nude mouse xenograft models.
Fluorescent Dye   Integrin  
Cancer  
/
HY-183217 Dextran-Biotin (MW 10 kDa)
Dextran-Biotin (MW 10 kDa) is a functional material formed by covalently linking biotin to dextran molecules. Dextran-Biotin combines the biocompatibility of dextran with the high affinity of biotin for streptavidin, and is widely used in research fields such as biolabeling, detection, drug delivery, and neural tracking.
Biochemical Assay Reagents  
/
HY-P992247 Anti-IL-31 Antibody
Anti-IL-31 Antibody is a monoclonal antibody that targets IL-31. Anti-IL-31 Antibody can be used in ELISA, FACS, and functional assays.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P992311 Anti-USAG-1 Antibody
Anti-USAG-1 Antibody is a monoclonal antibody that targets SOSTDC1. Anti-USAG-1 Antibody can be used in ELISA, FACS, and functional assays.

Species: Human

TGF-beta/Smad  
Inflammation or Immune System Disease  
/
HY-P2655 Antho-RFamide
Antho-RFamide is a neuropeptide isolated from the sea anemone (Anthopleura elegantissima). Antho-RFamide contains a specific carboxyl-terminal sequence, Arg-Phe-NH2, that plays an important role in neural signaling. Antho-RFamide can be used to study the function of neuropeptides in the nervous system of the simplest animals.
Others  
/
HY-P992233 Anti-GPR64 Antibody
Anti-GPR64 Antibody is a monoclonal antibody that targets GPR64/ADGRG2. Anti-GPR64 Antibody can be used in ELISA, FACS, and functional assays.

Species: Human

Adhesion G Protein-coupled Receptors (AGPCRs)  
Inflammation or Immune System Disease  
/
HY-D2996 BOD-NH-SC
BOD-NH-SC is a dual-response fluorescent reporter molecule exhibiting activatable NIR II fluorescence, with a primary absorption peak at 664 nm. BOD-NH-SC detects the dynamic alternation of NO and H2S in living cells.
Fluorescent Dye   NO Synthase  
/
HY-P992256 Anti-LCAT Antibody
Anti-LCAT Antibody is a monoclonal antibody targeting LCAT. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LCAT Antibody, please refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Species: Human

Acyltransferase  
Inflammation or Immune System Disease  
/
HY-W008440S DL-Cycloserine-15N,d3
DL-Cycloserine-15N,d3 is the deuterium labeled DL-Cycloserine (HY-W008440). DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states.
Isotope-Labeled Compounds   Aminotransferases (Transaminases)   Monoamine Oxidase  
Depression   Tuberculosis  
/
HY-P11842 Ac-HFKLYWPPFLGS-NH2
Ac-HFKLYWPPFLGS-NH2 is a RMI1/2 heterodimer inhibitor with an IC50 of 99 nM and antiproliferative activity. Ac-HFKLYWPPFLGS-NH2 binds competitively at the FANCM-RMI interaction interface, mimics native FANCM MM2 domain hydrophobic interactions, and adopts a unique binding pose with additional protein interactions. Ac-HFKLYWPPFLGS-NH2 induces antiproliferative effects in ALT-positive osteosarcoma cells. Ac-HFKLYWPPFLGS-NH2 shows limited stability toward α-chymotrypsin-mediated enzymatic degradation in vitro. Ac-HFKLYWPPFLGS-NH2 lacks inherent cell permeability, requiring conjugation to a cell-penetrating peptide for intracellular delivery. Ac-HFKLYWPPFLGS-NH2 can be used for the research of ALT-positive osteosarcoma.
DNA/RNA Synthesis  
Musculoskeletal and Skin Disease   Osteosarcoma  
/
HY-W800535 Cryptolepine
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection.
NF-κB   p38 MAPK   mTOR   Topoisomerase   AMPK   Apoptosis   Cholinesterase (ChE)   HIF/HIF Prolyl-Hydroxylase   β-catenin  
Breast Cancer   Colorectal Cancer   Liver Cancer   Melanoma   Viral Infection   Bacterial Infection   Parasitic Infection   Autoimmune Disease   Glucose Metabolism  
/
HY-P992304 Anti-SOSTDC1 Antibody
Anti-SOSTDC1 Antibody is a monoclonal antibody that targets SOSTDC1. Anti-SOSTDC1 Antibody can be used in ELISA, FACS, and functional assays.

Species: Human

TGF-beta/Smad  
Inflammation or Immune System Disease  
/
HY-130509S MTSSL-15N
MTSSL-15N (Otmpmms-15N) is the 15N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is a highly reactive thiol-specific spin label that can be used to label thiol residues in proteins for the determination of protein structure and dynamics, as well as studies on protein-protein interactions. MTSSL serves as a nitroxide labeling reagent for cysteine residues in recombinant mouse prion protein (moPrPC) mutants. MTSSL can be applied in studies of transmissible spongiform encephalopathies (prion diseases).
Isotope-Labeled Compounds   Biochemical Assay Reagents  
/
HY-P10428 E6AP-mimicking peptide
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture.
HPV  
Infection  
/
HY-P11830 UDA-6
UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity.
Amylin Receptor  
Obesity  
/
HY-P11322 NHIP peptide
NHIP peptide is a peptide segment containing 20 amino acids located in the nucleus of the cell. NHIP is highly expressed in neuronal derived cells such as LUHMES cells. NHIP peptide can promote the proliferation of 293T cells. NHIP peptide regulates gene networks related to neural development and autism spectrum disorder (ASD).
Amino Acid Derivatives  
Neurological, Eye or Ear Disease  
/
HY-W698686 β-Galactosyl-C18-ceramide
β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.
Biochemical Assay Reagents  
/
HY-P1176A NTR 368 TFA
NTR 368 TFA is a peptide derived from p75 neurotrophin receptor (p75NTR) corresponding to residues 368-381 of the human receptor. NTR 368 TFA has helix forming propensity in the presence of micellar lipid. NTR 368 TFA is a potent inducer of neural apoptosis.
Apoptosis  
Neurological, Eye or Ear Disease  
/
HY-147114 3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin
3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is a DNA uptake tracer, a pteridine-based fluorescent guanosine analogue. 3-Methyl-8-(2'-deoxy-β-D-ribofuranosyl)isoxanthopterin is widely used in studies of DNA binding and dynamics, with an absorbance maximum at 350 nm and an emission maximum at 430 nm.
Fluorescent Dye  
/
HY-N1838 Dehydromaackiain
Dehydromaackiain is a potent Neurogenin2 (Ngn2) promoter activator. Dehydromaackiain promotes differentiation of neural stem cells into neurons.
Others  
Neurological, Eye or Ear Disease  
/
HY-D3415 TOR-G4
TOR-G4 is a Fluorescent probe that binds to G-quadruplex (G4) nucleic acid structures. TOR-G4 exhibits a unique fluorescence lifetime when bound to G4 compared to other structures, enabling sensitive discrimination between G4-bound and non-G4-bound states. TOR-G4 mainly colocalizes with RNA in the cytoplasm and nucleolus. TOR-G4 can be used to investigate the roles of RNA G4 in cells. TOR-G4 shows cytotoxicity against osteosarcoma cells.
Fluorescent Dye   G-quadruplex  
Cancer  
/
HY-16900G Rolipram (GMP)
Rolipram GMP is Rolipram (HY-16900) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis.
Phosphodiesterase (PDE)   Epigenetic Reader Domain   Amyloid-β  
Depression   Glioblastoma Multiforme   Alzheimer's Disease   Multiple Sclerosis  
/
HY-P4084 KLA seq
KLA seq is a cell-penetrating α-helical amphipathic model peptide.
Others  
/
HY-113896 U-67827E
U-67827E is a cholecystokinin (CCK) agonist that decreases food intake over a prolonged period of time in baboons. U-67827E may affect the latency to food by inhibiting the movement of food in the stomach and magnifying a gastric distention signal.
Cholecystokinin Receptor  
/
HY-D2939 BGSBD
BGSBD is a SNAP-tag-based fluorescent probe (Ex/Em: 435 nm/516 nm) based on the environmentally sensitive fluorescent group SBD, specifically designed for protein labeling of live cells without washing. BGSBD achieves a 280-fold fluorescence enhancement after labeling by ingeniously utilizing the hydrophobic binding pocket of the SNAP-tag protein, providing an ideal tool for real-time monitoring of protein dynamics within cells.
Fluorescent Dye  
/
HY-183217B Dextran-Biotin (MW 70 kDa)
Dextran-Biotin (MW 70 kDa) is a functional material formed by covalently linking biotin to dextran molecules. Dextran-Biotin combines the biocompatibility of dextran with the high affinity of biotin for streptavidin, and is widely used in research fields such as biolabeling, detection, drug delivery, and neural tracking.
Biochemical Assay Reagents  
/
HY-P10472 Azaline B
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception.
GnRH Receptor  
Metabolic or Endocrine Disease  
/
HY-Y1754 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid
2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) is a compound with the ability to probe conformational changes, folding processes and interactions of peptides and proteins. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid is often used in relevant biological research to gain a deeper understanding of the behavior and function of biomacromolecules. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid plays an important role in analyzing the interactions and dynamic responses of biological systems.
Biochemical Assay Reagents  
/
HY-101559S 10-Nitrooleate-d17 nitrate
10-Nitrooleate-d17 (nitrate) is the deuterium labeled 10-Nitrooleic acid nitrate. 10-Nitrooleic acid (CXA-10) nitrate, a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-P3684 [DPro5] Corticotropin Releasing Factor, human, rat
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.
CRFR  
Metabolic or Endocrine Disease  
/
HY-155919 mPEG2000-CHO
mPEG2000-CHO participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
Biochemical Assay Reagents  
/
HY-ER013E Sodium carbonate anhydrous, United States Pharmacopeia (USP) Reference Standard
Sodium carbonate anhydrous, United States Pharmacopeia (USP) Reference Standard can be used as as a standard of reference in acidimetry.
Others  
/
HY-107413G SR11237 (GMP)
SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease.
RAR/RXR   Tyrosine Hydroxylase  
Inflammation or Immune System Disease   Parkinson's Disease   Osteoarthritis  
/
HY-135525 Agroclavine
Agroclavine acts as an agonist of the D1-dopamine receptor and α1-adrenergic receptor. Agroclavine enhances the sensitivity of the brain to magnetic fields; it impairs spatial memory without affecting hippocampal long-term potentiation (LTP). Agroclavine exerts bidirectional regulatory effects on immune activity: it enhances NK cell activity with low toxicity under normal conditions, while it inhibits NK cell activity and exhibits significant cardiac and hepatic toxicity under stress conditions. Agroclavine can be used for research on neuroelectrophysiology, learning and memory, and immunoregulation.

Source: Saccharomyces cerevisiae

Dopamine Receptor   Adrenergic Receptor  
Neurodegenerative Disease   Immunomodulation  
/
HY-D1852 Cy3B amine chloride
Cy3B amine chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-D1318 Cyanine7.5 azide chloride
Cyanine7.5 azide chloride is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with an azide functional group. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The azide group of Cyanine7.5 azide chloride can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Cyanine7.5 azide chloride can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-P1920 CEF19, Epstein-Barr Virus latent NA-3A (458-466)
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition.
EBV  
Inflammation or Immune System Disease  
/
HY-P992358 GSK2394002
GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys.

Species: Human

ADAMTS  
Cardiovascular Disease  
/
HY-W251598J Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard
Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
Bacterial   NO Synthase  
Cancer   Gastric Disease  
/
HY-N0459R 3,5-O-Dicaffeoylquinic acid (Standard)
3,5-O-Dicaffeoylquinic acid (Standard) is the analytical standard of 3,5-O-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits.
Reference Standards   Others  
Neurological, Eye or Ear Disease  
/
HY-N0469S2 L-Lysine-15N-1 dihydrochloride
L-Lysine-15N-1 (dihydrochloride) is the 15N-labeled L-Lysine. L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.
Endogenous Metabolite   Virus Protease  
Inflammation or Immune System Disease  
/
HY-W740363 5-Aminofluorescein hydrochloride
5-Aminofluorescein hydrochloride (5-AF hydrochloride) is a protein fluorescent labeling reagent with excellent fluorescence activity. It is widely used in cell imaging and molecular probes in biomedical research. 5-Aminofluorescein hydrochloride can be used to observe the location of proteins and their dynamic changes, providing in-depth biological understanding. 5-Aminofluorescein hydrochloride is also used to detect interactions between biomolecules and help analyze complex biological processes.
Fluorescent Dye  
/
HY-N13795 3,4,3'-Tri-O-methylflavellagic acid
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid inhibitor that targets αβ-tubulin (colchicine binding site) and polo-like kinase-1 (PLK-1), and can be isolated from the roots of Anogeissus leiocarpus. 3,4,3'-Tri-O-methylflavellagic acid interferes with microtubule assembly dynamics and kinase activity, exhibiting anti-cancer cell proliferation and potent anti-nociceptive effects.
Polo-like Kinase (PLK)   Microtubule/Tubulin  
Cancer  
/
HY-126644 Halocyamine B
Halocyamine B exhibits antimicrobial activity against a variety of bacteria and yeasts. Halocyamine B exhibits cytotoxicity to cultured neural cells of rat fetal brain, mouse neuroblastoma N18 cells, and human hepatoma HepG2 cells.

Source: Halocynthia roretzi (a sea squirt)

Bacterial   Fungal  
Cancer   Infection  
/
HY-D3179 CDg13
CDg13 is a fluorescent probe that specifically detects living neural stem/progenitor cells. CDg13 localizes to the endoplasmic reticulum via its dihexyl moiety, with no interaction with endoplasmic reticulum biomolecules. CDg13 undergoes selective efflux by active ABCG2 transporters, with increased intracellular accumulation following ABCG2 inhibition or knockdown. CDg13 isolates and enriches self-renewable neural stem/progenitor cells from embryonic mouse brain tissue, stains neural stem/progenitor cells brightly, and sorts ABCG2low cell populations from heterogeneous populations. (Ex/Em = 520/553 nm)
Fluorescent Dye   BCRP  
Neurological, Eye or Ear Disease  
/
HY-P11137 LANA
LANA is a KSHV latency-associated nuclear antigen. The core function of LANA is to act as an "anchor" for the viral genome, attaching it to the chromatin of the host cell. LANA ensures that the episomal DNA of KSHV replicates together with the host chromosome and is evenly distributed among the daughter cells, thereby maintaining the latent infection of the virus in the cell population. LANA can regulate the transcription of viral and host cell genes, and regulate certain host cell genes to promote cell survival. LANA can be used to study the viral DNA tethering structure.
HSV  
Cancer  
/
HY-P5319 MCaE12A
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell.
Calcium Channel  
/
HY-155918 mPEG1000-CHO
mPEG1000-CHO participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
Biochemical Assay Reagents  
/
HY-W004305R Hexadecanal (Standard)
Hexadecanal (Standard) is an analytical standard for Hexadecanal. This product is intended for research and analytical applications. Hexadecanal (Palmitaldehyde), a volatile, long-chain fatty aldehyde, is released from human feces, skin, and breath. The hexadecanal receptor (OR37B) is highly conserved in mammals. Hexadecanal may exert its effects by modulating functional connectivity between social evaluation brain substrates and aggression execution brain substrates. Hexadecanal has also been shown to have a strong deterrent effect on black ants. Hexadecanal has potential for use in startle response and aggression behavior
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-13716S Noscapine-13C,d3
Noscapine-13C,d3 is a 13C- labeled and deuterated labeled Noscapine. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier.
Isotope-Labeled Compounds   Apoptosis   Opioid Receptor  
Cancer  
/
HY-183217A Dextran-Biotin (MW 40 kDa)
Dextran-Biotin (MW 40 kDa) is a functional material formed by covalently linking biotin to dextran molecules. Dextran-Biotin combines the biocompatibility of dextran with the high affinity of biotin for streptavidin, and is widely used in research fields such as biolabeling, detection, drug delivery, and neural tracking.
Biochemical Assay Reagents  
/
HY-W540661 Hyaluronic acid tetrasaccharide, 98%
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.
Biochemical Assay Reagents  
/
HY-155921 mPEG5000-CHO
mPEG5000-CHO participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
Biochemical Assay Reagents  
/
HY-P11743 Mitochondrial penetrating peptide
Mitochondrial penetrating peptide is a peptide sequence (FrFKFrFK-CONH2) that selectively transports cargo into mitochondria. Mitochondrial penetrating peptide possesses special physicochemical properties, enabling it to selectively translocate dinuclear Ru (II) polypyridine complexes into mitochondria of living mammalian cells without the aid of solvents or membrane permeabilization treatments, thus achieving precise mitochondrial localization and enrichment of the complexes while excluding their distribution in the nucleus. Mitochondrial penetrating peptide enables dynamic monitoring of mitochondrial oxygen concentration and ROS production in living mammalian cells via changes in the luminescence lifetime of the coupled Ru (II) complex.
Biochemical Assay Reagents   Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
/
HY-W012642A 2-Aminopurine dihydrochloride
2-Aminopurine dihydrochloride is a fluorescent analog of guanosine. 2-Aminopurine dihydrochloride can be used as a fluorescence probe for nucleic acid structure and dynamics. Incorporating 2-Aminopurine dihydrochloride into DNA quenches its fluorescence.
DNA Stain  
/
HY-D1859 Sulfo-Cy7.5 alkyne
Sulfo-Cy7.5 alkyne is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) containing a sulfonate ion and an alkyne functional group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The alkyne functionality of Sulfo-Cy7.5 alkyne can react with molecules containing the azide functionality to form covalent bonds. Sulfo-Cy7.5 alkyne can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-W724404 N-Oleoyl serinol-d5
N-Oleoyl serinol-d5 (Oleoyl serinol-d5) is the deuterium labeled N-Oleoyl serinol (HY-122788). N-Oleoyl serinol is a ceramide analog that can be used in stem cell therapy to prevent stem cells from developing into teratomas. N-Oleoyl serinol induces apoptosis in residual pluripotent embryoid body-derived cells (EBCs), prevents teratoma formation, and enriches EBC cells that undergo neural differentiation after transplantation.
Isotope-Labeled Compounds   Apoptosis  
Cancer  
/
HY-D2940 SiR-SNAP
SiR-SNAP (SiR650-BG) is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells.
Fluorescent Dye  
/
HY-P992190 Anti-Apelin Antibody
Anti-Apelin Antibody is a monoclonal antibody that targets apelin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-Apelin Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Apelin Receptor (APJ)  
Inflammation or Immune System Disease  
/
HY-N2682A (E)-Dehydrodiconiferyl alcohol
(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors. And (E)-Dehydrodiconiferyl alcohol suppresses the NF-κB nuclear translocation in connective tissue of healing area.
Carbonic Anhydrase  
Cancer  
/
HY-P2642 Peptide 78
Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA).
CXCR  
Inflammation or Immune System Disease  
/
HY-D3007 LD-CK
LD-CK is a fluorescent probe based on a coumarin-chromone structure, specifically designed to visualize lipid droplet polarity changes and endowed with multimodal imaging capability. LD-CK contains a high-performance lipophilic coumarin moiety, which enables it to specifically target lipid droplets upon cellular entry while minimizing background fluorescence to the greatest extent. LD-CK has an excitation wavelength (Ex) of 488 nm and an emission wavelength (Em) of 540 nm (in low-polarity environments such as toluene) or 640 nm (in high-polarity environments such as glycerol), with its emission peak undergoing a redshift as solvent polarity increases.
Fluorescent Dye  
/
HY-P992234 Anti-Heparanase Antibody
Anti-Heparanase Antibody is a monoclonal antibody that targets heparanase. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-heparanase antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Glycosidase  
Inflammation or Immune System Disease  
/
HY-P11629 KBP-336
KBP-336 is a dual amylin and calcitonin receptor agonist (DACRA). KBP-336 exhibits antidiabetic and insulin-sensitizing properties, improves glucose levels, spatial learning, and memory in diabetic rats, and reduces blood glucose. KBP-336 also alleviates pain-like symptoms in osteoarthritis rats. KBP-336 also promotes weight and fat reduction. KBP-336 is useful for research on diabetes, obesity, and arthritis.
Amylin Receptor   CGRP Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D2620 CAR-2
CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LDs). CAR-2 exhibits phototoxicity in breast cancer cells with IC50 of 0.01-0.02 μM. CAR-2 exhibits antitumor efficacy in 4T1 xenograft mouse models.
Photosensitizer   Reactive Oxygen Species (ROS)   Ferroptosis  
/
HY-N0565AG Doxycycline (hydrochloride) (GMP)
Doxycycline hydrochloride GMP is Doxycycline (hydrochloride) (HY-N0565A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Doxycycline hydrochloride is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hydrochloride is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hydrochloride also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hydrochloride induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hydrochloride also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hydrochloride has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
Apoptosis   MMP   Akt   PI3K  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Breast Cancer   Prostate Cancer   Bladder Cancer  
/
HY-113218S Acetyl-L-carnitine-d9
Acetyl-L-carnitine-d9 (O-Acetyl-L-carnitine-d9) is deuterium labeled Acetyl-L-carnitine. Acetyl-L-carnitine (O-Acetyl-L-carnitine) is a compound involved in human metabolic research. It has relevant applications in predicting metabolite biomarker changes using the Recon 2 metabolic reconstruction model and integrating and analyzing multiple data types, but its specific activity mechanism is not described in detail based on the existing information.
Isotope-Labeled Compounds  
/
HY-P1704 Cyclosporin E
Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide that can be isolated from fungi such as TTrichoderma polysporum and other imperfect fungi. Cyclosporin E belongs to the Cyclosporins family. Cyclosporin E can be used for studying the structure-activity relationships and molecular dynamic properties of cyclosporin compounds. As a structural control compound, Cyclosporin E holds significant research value in the fields of medicinal chemistry and biophysics.

Source: Trichoderma polysporum

Biochemical Assay Reagents  
Infection  
/
HY-121467S Acotiamide-d6
Acotiamide-d6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia.
Isotope-Labeled Compounds   Cholinesterase (ChE)  
Metabolic or Endocrine Disease  
/
HY-12273G DMH-1 (GMP)
DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 (GMP) is a selective BMP inhibitor. DMH-1 (GMP) upregulates the expression of SOX1. DMH-1 (GMP) increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 (GMP) induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons.
Organoid   TGF-β Receptor   Microtubule/Tubulin  
Neurological, Eye or Ear Disease   Heart Disease  
/
HY-W094475E Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard
Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard (Epsom salts (Pharmaceutical primary standard, USP)) is a reference standard for Magnesium sulfate (HY-Y1267). Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.
Environmental Pollutants   Interleukin Related   Phospholipase   COX   Calcium Channel   Biochemical Assay Reagents   NO Synthase   NF-κB  
Inflammation or Immune System Disease   Traumatic Brain Injury   Arrhythmias  
/
HY-12651S Primaquine-d3 diphosphate
Primaquine-d3 (diphosphate) is the deuterium labeled Primaquine diphosphate. Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale.
Isotope-Labeled Compounds   Parasite  
Infection  
/
HY-P99820 Ranevetmab
Ranevetmab (NV-01) is a caninised anti-NGF monoclonal antibody (mAb). Ranevetmab can alleviate pain, and is used for the research of degenerative joint disease (DJD) pain.

Species: Canlupfam

TNF Receptor  
Inflammation or Immune System Disease  
/
HY-B1953S Thiacloprid-d4
Thiacloprid-d4 is the deuterium labeled Thiacloprid. Thiacloprid is an orally active neurotoxic insecticide and also a nAChR agonist. Thiacloprid reduces the viability of healthy cells, depletes reduced glutathione, and increases MDA levels, thereby inducing cytotoxicity and oxidative stress damage. In practical applications, Thiacloprid has lower acute toxicity to honeybees than other compounds of the same class such as Imidacloprid (HY-B0838), but it still significantly impairs the learning and memory function, immune capacity and survival status of honeybees. Thiacloprid induces intestinal microbial dysbiosis and reduces survival rate in middle-aged honeybees, increases the risk of premature collapse in bumblebee colonies, and significantly decreases the final colony weight and reproductive output. Thiacloprid is used in broad-spectrum agricultural pest control, often alone or in combination with Deltamethrin (HY-B1971), and meets the pest management needs of various crops including potatoes, cabbages, various fruits and vegetables, and nuts.
nAChR   Insecticide  
Infection  
/
HY-129440R N-(p-Coumaroyl) Serotonin (Standard)
N-(p-Coumaroyl) Serotonin (Standard) is the analytical standard of N-(p-Coumaroyl) Serotonin (HY-129440). This product is intended for research and analytical applications. N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
Reference Standards   PDGFR   ERK   Caspase   NF-κB   Toll-like Receptor (TLR)   p38 MAPK   NO Synthase   COX   MyD88   Reactive Oxygen Species (ROS)   Apoptosis  
Neurodegenerative Disease   Glioblastoma   Atherosclerosis and Inflammation   Renal Failure  
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HY-158741 IPG-2 AM
IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics.
Fluorescent Dye   Potassium Channel  
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HY-164160 1,2-Dipalmitoyl-rac-glycero-3-phospho-L-serine
1,2-Dipalmitoyl-rac-glycero-3-phospho-L-serine (DPPS) is a phospholipid compound with good membrane-forming ability. 1,2-Dipalmitoyl-rac-glycero-3-phospho-L-serine can form stable and well-defined bilayers, which are suitable for the study of membrane dynamics. 1,2-Dipalmitoyl-rac-glycero-3-phospho-L-serine is often used to prepare liposomes for various applications in the biomedical field.
Biochemical Assay Reagents  
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HY-107203S Propentofylline-d6
Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
Isotope-Labeled Compounds   Phosphodiesterase (PDE)   Adenosine Receptor  
Colorectal Cancer   Alzheimer's Disease  
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HY-N0614GL Sucralose (GMP Like)
Sucralose (GMP Like) (E955 (GMP Like)) is the GMP Like class Sucralose (HY-N0614) that can be used as pharmaceutical excipients. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents.
Endogenous Metabolite  
Cancer  
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HY-16637S5 Folic acid-13C6
Folic acid-13C6 is a deuterated labeled Folic acid. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
Isotope-Labeled Compounds   DNA/RNA Synthesis   Endogenous Metabolite  
Cancer  
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HY-W007577R 4-Nitrobenzaldehyde (Standard)
4-Nitrobenzaldehyde (Standard) is the analytical standard of 4-Nitrobenzaldehyde (HY-W007577). This product is intended for research and analytical applications. 4-Nitrobenzaldehyde is a widely used industrial chemical intermediate and also the main photodegradation product of the broad-spectrum antibiotic Chloramphenicol (HY-B0239). 4-Nitrobenzaldehyde has genotoxic and mutagenic effects and poses a certain threat to human health and ecosystems.
Reference Standards   Drug Metabolite  
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HY-D2376 BH-Vis
BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model.
Fluorescent Dye  
Cancer  
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HY-108715R Real Thiol (Standard)
Real Thiol (Standard) is the analytical standard of Real Thiol (HY-108715). This product is intended for research and analytical applications. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
Fluorescent Dye   Reference Standards  
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HY-13681S Methylprednisolone acetate-d6
Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.
Glucocorticoid Receptor   Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
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HY-16774S Vericiguat-d3 hydrochloride
Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase.
Isotope-Labeled Compounds  
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HY-W018324S 5-Hydroxymethylcytosine-13C,d2
5-Hydroxymethylcytosine-13C,d2 is the 13C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes).
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
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HY-W776847 3-(2-Iodoacetamido)-proxyl
3-(2-Iodoacetamido)-proxyl serves as a free radical spin probe employed in spin labeling techniques, which facilitate the exploration of the dynamic interactions among molecules, proteins, lipids, and cell membranes.
Fluorescent Dye  
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HY-101893R Dihydrofluorescein diacetate (Standard)
Dihydrofluorescein diacetate (Standard) is the analytical standard of Dihydrofluorescein diacetate (HY-101893). This product is intended for research and analytical applications. Dihydrofluorescein diacetate is a fluorimetric probe mainly used for oxidative stress measurements, in both cell-free systems and cellular models.
Fluorescent Dye   Reference Standards  
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HY-107302 Sandosaponin A
Sandosaponin A (Soyasaponin Bd) is a saponin with inhibitory activity against human recombinant aldehyde reductase (hAKR1B1). Sandosaponin A can inhibit the reduction of l-idose and 4-hydroxynonenal to varying degrees. The presence of Sandosaponin A reveals the challenges posed by the masking effect of conventional aldehyde reductase inhibitors in mixtures when exploring differential aldehyde reductase inhibitors. The inhibitory mechanism of Sandosaponin A may be related to its mode of action on different substrates.
Endogenous Metabolite  
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HY-W452285 Isoplumbagin
Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function.
Antibiotic   Bacterial  
Cancer   Infection   Inflammation or Immune System Disease  
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HY-D3011 2-AS
2-AS is a fluorescent probe and can monitor the microenvironment and dynamic changes of biofilms.
Fluorescent Dye  
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HY-138166S Rosuvastatin lactone-d6
Rosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.
Isotope-Labeled Compounds   NO Synthase   Drug Metabolite   Potassium Channel  
Blood or Cardio-cerebrovascular Disease  
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HY-B0684S Iopamidol-d8
Iopamidol-d8 (B-15000-d8) is the deuterium labeled Iopamidol. Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast.
Isotope-Labeled Compounds  
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HY-122607S DPA-714-d10
DPA-714-d10 is the deuterium labeled DPA-714 (HY-122607). DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
Isotope-Labeled Compounds   TSPO   Mitochondrial Metabolism  
Cancer   Inflammation or Immune System Disease  
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HY-12323G ISX-9 (GMP)
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.
Calcium Channel  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
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HY-N0469S L-Lysine-d3 hydrochloride
L-Lysine-d3 (hydrochloride) is the deuterium labeled L-Lysine. L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.
Endogenous Metabolite   Virus Protease  
Inflammation or Immune System Disease  
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HY-B0647S1 Butylphthalide-d3
Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
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HY-107372S4 Uridine triphosphate-15N2 dilithium
Uridine triphosphate-15N2 (UTP-15N2 dilithium; Uridine 5'-triphosphate-15N2) dilithium is 15N labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
Isotope-Labeled Compounds   Endogenous Metabolite   DNA/RNA Synthesis  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
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HY-W099642 Trimethyloctylammonium bromide
Trimethyloctylammonium bromide (TOAB) is used as a surfactant and phase transfer catalyst in various chemical reactions. TOAB can be used in the synthesis of nanomaterials due to its ability to selectively transfer ions across interfaces and as a surfactant in the production of emulsions and foams. It is valued for its amphiphilic properties, which allow it to interact with water and oils, stabilizing and dispersing mixtures.
Biochemical Assay Reagents  
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HY-Y1322S Triphenyl phosphate-d15
Triphenyl phosphate-d15 is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.
JNK   Apoptosis   Isotope-Labeled Compounds   Indoleamine 2,3-Dioxygenase (IDO)   Akt   Reactive Oxygen Species (ROS)   PPAR   ERK   NF-κB   Mitophagy   PI3K   Environmental Pollutants   p38 MAPK   Monoamine Oxidase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Urogenital Disease  
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HY-107372S3 Uridine triphosphate-d13 dilithium
Uridine triphosphate-d13 (UTP-d13 dilithium; Uridine 5'-triphosphate-d13) dilithium is deuterium labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
Isotope-Labeled Compounds   Endogenous Metabolite   DNA/RNA Synthesis  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
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HY-P10607 IALYLQQNW
IALYLQQNW is a specific nonapeptide sequence derived from the tumor-associated antigen latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV). As a latent T-cell epitope, IALYLQQNW is able to activate EBV-specific cytotoxic T lymphocytes (CTLs), which are able to recognize and kill EBV-infected cells expressing LMP1. IALYLQQNW plays an important role in the immune response against EBV-associated tumors and can be used in the study of Hodgkin's disease and nasopharyngeal carcinoma.
EBV  
Cancer   Infection  
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HY-P11742 WALP23
WALP23 is a synthetic model peptide. WALP23 induces heterogeneity in lipid bilayers, forming stripe-like microdomains in DPPC bilayers. WALP23 can be used to study protein-membrane interactions. WALP23 is also used as a model peptide to determine helical orientation during the association process.
Biochemical Assay Reagents  
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HY-15037S2 Diclofenac-13C6 sodium
Diclofenac-13C6 (Sodium) is the 13C6 labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
Isotope-Labeled Compounds   COX   Apoptosis  
Inflammation or Immune System Disease  
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HY-P990214 Anti-Mouse IL-3 Antibody (MP2-8F8)
Anti-Mouse IL-3 Antibody (MP2-8F8) is an anti-mouse IL-3 IgG1 monoclonal antibody. Anti-Mouse IL-3 Antibody (MP2-8F8) relieves joint inflammation by reducing synovial leukocyte infiltration and cytokine levels. Anti-Mouse IL-3 Antibody (MP2-8F8) can reduce the accumulation of basophils. Anti-Mouse IL-3 Antibody (MP2-8F8) can be used for researches on inflammation or infection conditions such as arthritis and parasitic infections.

Species: Mouse

Interleukin Related   Parasite  
Infection   Inflammation or Immune System Disease  
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HY-N0614S Sucralose-d6
Sucralose-d6 is deuterium labeled Sucralose. Sucralose?(E955; Trichlorosucrose) is a?non-nutritive?artificial?sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents.
Endogenous Metabolite  
Cancer  
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HY-W674241A 4-Ethylphenyl sulfate sodium
4-Ethylphenyl sulfate sodium is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate sodium downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate sodium induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate sodium impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate sodium alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice.

Source: goat urine

Endogenous Metabolite   Apoptosis   Bcl-2 Family   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease  
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HY-P1495 Small Cardioactive Peptide B (SCPB)
Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
Adenylate Cyclase  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
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HY-W014861 Tetramethylammonium iodide
Tetramethylammonium iodide (Tetramethyl-ammoniuiodide) is a capillary active agent and weakly capillary active quasi-simple salt. Tetramethylammonium iodide decreases aqueous solution surface tension with increasing concentration and exhibits surface accumulation of constituent ions at liquid-vapor interfaces.
Biochemical Assay Reagents  
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HY-W700437 threo-9,10-Dihydroxystearic acid
Threo-9,10-Dihydroxystearic acid is a synthetic dihydroxy fatty acid with the activity of altering lipid bilayer packing and fluidity. Threo-9,10-Dihydroxystearic acid can be used to study the dynamic properties of lipid membranes. Threo-9,10-Dihydroxystearic acid exhibits important biological functions in cell membranes or synthetic lipid models.
Biochemical Assay Reagents  
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HY-P6028 GSNKSKPK-NH2
GSNKSKPK-NH2 is a synthetic model peptide based on the c-Src N-terminal sequence and model peptide substrate for human NMT1 and NMT2.GSNKSKPK-NH2 facilitates in vitro assays measuring transfer of myristate or X10 fatty acid moieties.
N-myristoyltransferase  
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HY-N16475 Spinosyn L
Spinosyn L is a selective nicotinic acetylcholine receptors (nAChR) agonist. Spinosyn L causes sustained neural excitation and paralysis in insects. Spinosyn L is promising for research of pesticides for controlling Lepidoptera, Diptera, and other agricultural pests.

Source: Saccharopolyspora spinosa

nAChR  
Infection  
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HY-W012788S Maltol-d3
Maltol-d3 is a deuterium labeled Maltol (HY-W012788). Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine.
Isotope-Labeled Compounds   Endogenous Metabolite   Apoptosis  
Infection   Neurological, Eye or Ear Disease  
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HY-N10103 Neoschaftoside
Neoschaftoside is a C-glycosyl flavonoid EGFR modulator, antifungal agent, and piercing-sucking stimulant for planthoppers. Neoschaftoside forms stable EGFR complexes, restricts global protein movement, enhances related dynamic processes, and inhibits tumor progression. Neoschaftoside interacts with EGFR core regulatory genes associated with lung cancer. Neoschaftoside inhibits Botrytis cinerea. Neoschaftoside can be used in research related to lung cancer and Botrytis cinerea infections.
Fungal   EGFR  
Lung Cancer   Fungal Infection  
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HY-W021291 Butyl isothiocyanate
Butyl isothiocyanate inhibits the proliferation of breast cancer cells. Butyl isothiocyanate can inhibit carcinogen activating phase I enzymes and inhibits cancer cell proliferation through altering the telomerase activity, dynamics of microtubules as well as expression of histone deacetylases. Butyl isothiocyanate can be studied in anti-cancer research.
Biochemical Assay Reagents  
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HY-W776833 MTSSL-15N,d15-1
MTSSL-15N,d15-1 (Otmpmms-15N,d15) is the deuterium and 15N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is a highly reactive thiol-specific spin label that can be used to label thiol residues in proteins for the determination of protein structure and dynamics, as well as studies on protein-protein interactions. MTSSL serves as a nitroxide labeling reagent for cysteine residues in recombinant mouse prion protein (moPrPC) mutants. MTSSL can be applied in studies of transmissible spongiform encephalopathies (prion diseases).
Isotope-Labeled Compounds   Biochemical Assay Reagents  
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HY-D1260 FM-red
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx).
Fluorescent Dye  
Neurological, Eye or Ear Disease  
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HY-P10529 Ganglioside GM1-binding peptide p3
Ganglioside GM1-binding peptide p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptide p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 can be used to study the interaction between GM1 and its ligands.
Trk Receptor  
Infection  
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HY-P11017 LNSMGQD
LNSMGQD is a cyclic peptide fragment derived from desmoglein 1 (amino acids 81-86), which mimics trans-interactions and acts as part of the tandem peptide binding interface of desmoglein 2. LNSMGQD not only binds to desmoglein 1 and 3, but also effectively inhibits their homophilic trans-interactions, while reducing the probability of homophilic or heterophilic binding between desmoglein 2 and Dsc2, N-cadherin and E-cadherin. LNSMGQD is applicable to the research on disease mechanisms such as Crohn's disease and pemphigus vulgaris.
p38 MAPK   Cadherin  
Digestive System Disease   Digestive System Inflammation   Crohn's Disease  
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HY-15036S1 Diclofenac-13C6
Diclofenac-13C6 is the 13C6 labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
Isotope-Labeled Compounds   COX   Apoptosis  
Inflammation or Immune System Disease  
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HY-N1414 (E)-3',6-Disinapoylsucrose
(E)-3',6-Disinapoylsucrose is an orally active, blood-brain barrier permeable neuroprotective agent that inhibits Aβ protein aggregation. (E)-3',6-Disinapoylsucrose exerts anxiolytic, anti-inflammatory and cognitive-enhancing effects. (E)-3',6-Disinapoylsucrose regulates the TrkB/BDNF signaling pathway, inhibits the expression of NF-κB p65, reduces pro-inflammatory cytokine levels, and alleviates neuronal damage. (E)-3',6-Disinapoylsucrose also enhances the functions of central 5-HT and noradrenergic systems, thereby improving spatial learning and memory abilities and reducing anxiety-like behaviors. (E)-3',6-Disinapoylsucrose can be used for the research of related diseases such as Alzheimer's disease, depression, memory impairment and anxiety disorder.
Trk Receptor   NF-κB   Amyloid-β  
Depression  
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HY-107372S2 Uridine triphosphate-13C9 dilithium
Uridine triphosphate-13C9 (UTP-13C9 dilithium; Uridine 5'-triphosphate-13C9) dilithium is 13C-labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
Isotope-Labeled Compounds   Endogenous Metabolite   DNA/RNA Synthesis  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
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HY-W097792 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks.
DNA/RNA Synthesis  
/
HY-N9794 Isoboldine
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice.
Others  
Inflammation or Immune System Disease  
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HY-P1858 Urocortin III, mouse
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
CRFR  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-D2949 SNAP-549
SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation.
Fluorescent Dye  
/
HY-B1695R Methyl nicotinate (Standard)
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain.
Reference Standards   Others  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
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HY-W094846S Tetradecane-d30
Tetradecane-d30 (n-Tetradecane-d30) is the deuterium labeled Tetradecane (HY-W094846). Tetradecane (n-Tetradecane) is a low-temperature phase change material with a phase change temperature of 5°C and a latent heat of phase change of 220 J/g. Tetradecane undergoes solid-liquid phase transition around 5°C, and achieves temperature regulation by absorbing or releasing latent heat.
Isotope-Labeled Compounds  
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HY-126214S JH-RE-06-d6
JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.
DNA/RNA Synthesis  
Cancer  
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HY-P4742A 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research.
Biochemical Assay Reagents   Potassium Channel  
Neurological, Eye or Ear Disease  
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HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA
[DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin Releasing Factor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.
CRFR  
Neurological, Eye or Ear Disease  
/
HY-P1805 Calmodulin Binding Peptide 1
Calmodulin Binding Peptide 1 is a high-affinity (pM) CaM-binding peptide derived from smooth muscle myosin light chain kinase (MLCK peptide). The interface of the complex formed by Calmodulin Binding Peptide 1 and Ca2+-CaM can be specifically bound by small-molecule inhibitors, serving as a key target for selective regulation of smooth muscle contraction and development of anti-CaM drugs.
Calmodulin  
Neurological, Eye or Ear Disease  
/
HY-136213 Endoplasmic reticulum dye 1
Endoplasmic reticulum dye 1 is a rhenium (I)-based luminescent, membrane-permeable cell imaging reagent with low cytotoxicity, photobleaching resistance, and suitability for multicolor imaging. Endoplasmic reticulum dye 1 localizes to the nuclear membrane, endoplasmic reticulum, and nucleoplasmic reticulum in live cells. Endoplasmic reticulum dye 1 enables detection of exocytosis events, dynamic changes in nuclear membrane-derived phagosomes, and vesicle trafficking processes.
Fluorescent Dye  
/
HY-N2740 Agalloside
Agalloside is a neural stem cell differentiation activator that binds to Hes1, and it is found in Aquilaria agallocha. Agalloside promotes the differentiation of neural stem cells and increases the number of neurons. Agalloside can be used in studies related to neural stem cell differentiation.
Sirtuin  
Neurological, Eye or Ear Disease  
/
HY-W127699 Propionylcholine (p-toluenesulfonate)
Propionylcholine (p-toluenesulfonate) is an organic compound commonly used in biochemical research and neuroscience research. It can be used to study cholinergic signal transduction and esterase activity, and is widely used in biomedical research and pharmacological research. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.
Biochemical Assay Reagents  
/
HY-D2575 WYneN
WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-17591S Penicillin G-d5 potassium
Penicillin G-d5 (potassium) is the deuterium labeled Penicillin G potassium. Penicillin G potassium is a fast-acting antibiotic; used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas.
Isotope-Labeled Compounds   Bacterial   Antibiotic  
/
HY-134104 C20-Sphingosine
C20-Sphingosine is a long-chain base (LCB) that can be used in the study of neural development.
Others  
Neurological, Eye or Ear Disease  
/
HY-P990782 Efzofitimod
Efzofitimod is a splice variant of the aminoacyl-tRNA synthetase HARS1, which is fused with the Fc segment of a human antibody. Efzofitimod targets the neuronal phospholipid NRP2 (neuropilin-2) and has anti-inflammatory and immunomodulatory activities. Efzofitimod can downregulate the innate and adaptive immune responses in inflammatory disease states, suppressing indirect lung disease (ILD).

Species: Human

Aminoacyl-tRNA Synthetase  
Inflammation or Immune System Disease  
/
HY-113061R Pseudouridine (Standard)
Pseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation[4].
Reference Standards   Endogenous Metabolite   Nucleoside Antimetabolite/Analog   DNA/RNA Synthesis  
/
HY-13443F2 Exendin-4, Cy5 labeled
Exendin-4, Cy5-labeled (Exendin-4-Cys(Cy5)) is a covalently linked Cy5 fluorescent group to Exendin-4 (HY-13443), a GLP-1 receptor agonist. Exendin-4, Cy5-labeled enables the visualization imaging of β cells in vivo, especially for evaluating the expression dynamics of GLP-1R in type 2 diabetes models.
Fluorescent Dye  
Type 2 Diabetes  
/
HY-P99179 CTX-2026
CTX-2026 is a fully human antibody that binds to CD277. CTX-2026 shows an anti-tumor effect on ovarian tumor models. CTX-2026 can be used for the research of cancer.

Species: Human

Others  
Cancer  
/
HY-D1401 OG 488, acid
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences.
Fluorescent Dye  
/
HY-107377S Benzo[a]pyrene-d12
Benzo[a]pyrene-d12 is the deuterium labeled Benzo[a]pyrene. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.
Endogenous Metabolite  
Cancer  
/
HY-W016289 Antiarol
Antiarol (3,4,5-Trimethoxyphenol) is a phenolic compound present in the trunk of Coffea canephora. Antiarol is a metabolite produced by chicken cecal microbes, whose cecal content changes dynamically with the severity of wooden breast (WB; a muscle disease prevalent in broilers) and enters the plasma through circulation.
Endogenous Metabolite  
Muscle Disease  
/
HY-P10424 OPBP-1
OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research.
PD-1/PD-L1  
Lung Cancer   Breast Cancer   Colorectal Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer  
/
HY-P5220 Acetyl hexapeptide-1
Acetyl hexapeptide-1 (Melitane) is a biomimetic peptide that mimics the activity of α-melanocyte-stimulating hormone (α-MSH). Acetyl hexapeptide-1 regulates muscle contraction, thereby reducing facial expression lines. Acetyl hexapeptide-1 is one of the components of anti-aging skincare serums targeting dynamic wrinkles. Acetyl hexapeptide-1 can be used in research related to mild photoaged facial skin and premature gray hair.
Melanocortin Receptor  
/
HY-B1695S Methyl nicotinate-d4
Methyl nicotinate-d4 is the deuterium labeled Methyl nicotinate. Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-N0469S1 L-Lysine-13C6 dihydrochloride
L-Lysine-13C6 (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.
Endogenous Metabolite   Virus Protease  
Inflammation or Immune System Disease  
/
HY-132848 Polyvinylimidazole
Polyvinylimidazole (Vimdemer) is a weakly alkaline polyelectrolyte. Polyvinylimidazole can form an anticancer complex with Cadmium chloride. Polyvinylimidazole can be used as a model polyelectrolyte to study the adsorption properties of various minerals.
Biochemical Assay Reagents   Drug Intermediate  
Cancer  
/
HY-P10633 SmBiT Tag
SmBiT Tag is an 11-amino-acid short peptide with extremely low natural affinity for LgBiT, with a Kd value of approximately 190 μM. It serves as a core component of the NanoLuc Binary Technology (NanoBiT) system. NanoBiT is a bioluminescent reporter system based on protein fragment complementation technology, which is used to monitor dynamic protein-protein interactions in live cells and in vitro.
Amino Acid Derivatives  
/
HY-P10436 Braftide
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research.
Raf  
Colorectal Cancer   Liver Cancer   Pancreatic Cancer   Obesity  
/
HY-W034344 Sodium methanesulfonate
Sodium methanesulfonate is a hygroscopic atmospheric aerosol, which typically forms from the reaction of methanesulfonic acid with sodium chloride or sea salt particles. Sodium methanesulfonate can serve as a substrate for oxidation reactions, undergoing heterogeneous oxidation by hydroxyl radicals at the air-aerosol interface, thereby initiating subsequent aerosol-phase chain reactions. Sodium methanesulfonate exhibits significant temperature-dependent deliquescence and efflorescence properties; particularly at lower temperatures relevant to the troposphere, its deliquescence and efflorescence relative humidity increase accordingly.
Biochemical Assay Reagents  
/
HY-W674241 4-Ethylphenyl sulfate
4-Ethylphenyl sulfate is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice.

Source: goat urine

Endogenous Metabolite   Apoptosis   Bcl-2 Family   Reactive Oxygen Species (ROS)  
Cancer   Neurological, Eye or Ear Disease  
/
HY-N0293R Paeoniflorin (Standard)
Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.
Reference Standards   HSP  
Cancer   Infection   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-15036S Diclofenac-d4
Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
Isotope-Labeled Compounds   COX   Apoptosis  
Inflammation or Immune System Disease  
/
HY-P99925 Enoticumab
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively.

Species: Human

Notch  
Cancer   Metabolic or Endocrine Disease  
/
HY-135484 NDSB-195
NDSB-195 is protein stabilizer that enhances the dynamics of the β4-α2 loop of ubiquitin. NDSB-195 stabilizes Saccharomyces cerevisiae ubiquitin against guanidium chloride denaturation, increasing the onset temperature of heat denaturation in the presence of the denaturant.
Biochemical Assay Reagents  
Amino Acid/Protein Metabolism  
/
HY-15037S1 Diclofenac-d4 sodium
Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
COX   Apoptosis  
Inflammation or Immune System Disease  
/
HY-P5220A Acetyl hexapeptide-1 acetate
Acetyl hexapeptide-1 (Melitane) acetate is a biomimetic peptide that mimics the activity of α-melanocyte-stimulating hormone (α-MSH). Acetyl hexapeptide-1 acetate can regulate muscle contraction, thereby reducing facial expression lines. Acetyl hexapeptide-1 acetate is one of the components of anti-aging skin care essences targeting dynamic wrinkles. Acetyl hexapeptide-1 acetate can be used in studies related to mild photo-aged facial skin and premature graying of hair.
Melanocortin Receptor  
/
HY-D0003 Methyl Blue
Methyl blue belongs to the group of triaminotriphenylmethane dyes. Methyl blue is widely used as antiseptic dye in polychrome staining method and has applications in histological and microbiological staining solutions. Methyl blue has been used as a model to study the effect of various catalysts on photodegradation of dyes.
Environmental Pollutants   Bacterial  
Infection  
/
HY-W284558 Sodium hexadecyl sulfate
Sodium hexadecyl sulfate is a long-chain anionic surfactant. Sodium hexadecyl sulfate can act as an interface-regulating substance to form a soft layer on the surface of carbon nanotubes, guide proteins to adsorb in the correct orientation with active sites facing outward through electrostatic interactions, and significantly enhance the activity of immobilized enzymes. Sodium hexadecyl sulfate can replace or supplement SDS (HY-Y0316) in capillary gel electrophoresis (CGE).
Biochemical Assay Reagents  
/
HY-P3524 GRGESP
GRGESP is a collagen gel contraction inhibitor. GRGESP inhibits the spreading of human fibroblasts inside collagen gels and markedly decreased gel contraction. GRGDSP can be used for the research of connective tissue morphogenesis.
Others  
/
HY-113365S Cholestenone-d5
Cholestenone-d5 is the deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-101893 Dihydrofluorescein diacetate
Dihydrofluorescein diacetate is a fluorimetric probe mainly used for oxidative stress measurements, in both cell-free systems and cellular models.
Fluorescent Dye  
/
HY-P10506 CMX-8933
CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin. CMX-8933 increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increases the phosphorylation of JNK and c-Jun proteins, and increases the cellular levels of c-Jun and c-Fos mRNA. CMX-8933 can be used to study the role of ependymin in neuroplasticity, learning, memory formation, and neural regeneration.
JNK  
Pain  
/
HY-171179 BD-Oligo
BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-P991316 KD014
KD014 (DX-2400) is a human monoclonal antibody that selectively targets MMP‑14. KD014 inhibits collagen degradation and regulates the polarization of macrophages toward an anti-inflammatory/anti-tumor phenotype. KD014 alleviates joint damage in rheumatoid arthritis and suppresses tumor growth and invasion. KD014 can be used in studies related to breast cancer and rheumatoid arthritis.

Species: Human

MMP   NO Synthase  
Inflammation or Immune System Disease   Breast Cancer  
/
HY-W250152 Polycytidylic acid potassium
Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-129440 N-(p-Coumaroyl) Serotonin
N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
NF-κB   Toll-like Receptor (TLR)   p38 MAPK   NO Synthase   COX   ERK   Caspase   PDGFR   MyD88   Reactive Oxygen Species (ROS)   Apoptosis  
Neurodegenerative Disease   Glioblastoma   Atherosclerosis and Inflammation   Renal Failure  
/
HY-D2381 AF 488 maleimide
AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm).
Fluorescent Dye  
/
HY-D1272 Sulfo-Cy3 amine
Sulfo-Cy3 amine is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-B1695 Methyl nicotinate
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain.

Source: Mycobacterium tuberculosis

Others  
Inflammation or Immune System Disease   Hypertension  
/
HY-P990069 Linavonkibart
Linavonkibart (SRK 181) is a high-affinity, fully human antibody that selectively binds to latent TGFβ1 and inhibits its activation. Linavonkibart plays an important role in cancer.

Species: Human

Others  
Cancer  
/
HY-133527 OG 488, SE
OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-108715 Real Thiol
Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-W004305 Hexadecanal
Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-D1871 Cy3 maleimide chloride
Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Fluorescent Dye  
/
HY-P990667 STX-100
STX-100 (BG00011) is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer.

Species: Human

Integrin   TGF-beta/Smad  
Cancer   Lung Fibrosis  
/
HY-P990993 Emugrobart
Emugrobart (GYM-329, RG6237, RG-70240) is a humanized IgG1κ antibody targeting myostatin (Myostatin; GDF8). Emugrobart binds to pro-myostatin and latent myostatin, blocking their cleavage into mature myostatin; it also has a clearance function, which transports bound myostatin for degradation and allows for cyclic reuse. Emugrobart enhances muscle strength in mouse models of muscle atrophy and increases muscle mass in cynomolgus monkeys. Emugrobart can be used in research on spinal muscular atrophy and facioscapulohumeral muscular dystrophy.

Species: Human

TGF-beta/Smad  
Inflammation or Immune System Disease  
/
HY-P6028A GSNKSKPK-NH2 TFA
GSNKSKPK-NH2 TFA is a synthetic model peptide based on the c-Src N-terminal sequence and model peptide substrate for human NMT1 and NMT2.GSNKSKPK-NH2 TFA facilitates in vitro assays measuring transfer of myristate or X10 fatty acid moieties.
N-myristoyltransferase  
/
HY-P1858A Urocortin III, mouse TFA
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
CRFR  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-117401 5-Dodecanoylaminofluorescein
5-Dodecanoylaminofluorescein is an amphipathic (amphoteric) fluorescent probe (Ex/Em = 485 nm/515-535 nm), which consists of a hydrophilic fluorescein core and a hydrophobic dodecanoyl group (C12 fatty acid chain) linked by an amide bond. 5-Dodecanoylaminofluorescein is mainly used as an interface-localized radical trapping/indicator probe. Dodecanoylaminofluorescein can be used for the determination of the antioxidant properties of emulsions, or can serve as a lipophilic drug model for the study of passive skin penetration when encapsulated in tyrosine-derived nanospheres.
Fluorescent Dye  
/
HY-W134328 Blue dextran (MW 2000000)
Blue dextran (Dextran blue) (MW 2000000) is a high-molecular-weight long-chain polymer of D-glucose. Blue dextran (MW 2000000) serves as an important model macromolecular drug and molecular weight estimation marker, and can be used as a standard for gel permeation chromatography. The release of Blue dextran (MW 2000000) from alginate microspheres is regulated by preparation conditions; its release rate in a pH 6.8 environment is significantly faster than that in pH 1.2, and it exhibits release characteristics close to zero-order kinetics under this condition.
Biochemical Assay Reagents  
/
HY-P9992 Pelgifatamab
Peligifatamab is a PSMA-targeted α-radioimmunoconjugate with an EC50 of 1.2 nM against human targets. Peligifatamab induces DNA damage, DNA double-strand breaks, cell cycle arrest and apoptosis (Apoptosis) in PSMA-positive prostate cancer cells. Peligifatamab reduces cell viability in a manner dependent on cellular PSMA expression levels. Peligifatamab inhibits tumor growth and tumor-induced abnormal bone growth in prostate cancer bone metastasis models. Peligifatamab exhibits antitumor efficacy in subcutaneous prostate cancer models and xenograft models. Peligifatamab can be used for the research of metastatic castration-resistant prostate cancer.

Species: Human

PSMA   Apoptosis  
Castration-Resistant Prostate Cancer  
/
HY-W127702 Scopolamine methyl nitrate
Scopolamine methyl nitrate is an organic compound commonly used in neuroscience research and pharmacology research. It can be used to study the role and structure of acetylcholine receptors, and is widely used in drug development and research in related fields. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.
Biochemical Assay Reagents  
/
HY-W007577 4-Nitrobenzaldehyde
4-Nitrobenzaldehyde is a widely used industrial chemical intermediate and also the main photodegradation product of the broad-spectrum antibiotic Chloramphenicol (HY-B0239). 4-Nitrobenzaldehyde has genotoxic and mutagenic effects and poses a certain threat to human health and ecosystems.
Drug Metabolite  
/
HY-W250978A Ovalbumin, low endotoxin
Ovalbumin, low endotoxin are the major proteins in egg white. Ovalbumin, low endotoxin act as an allergen and inducer, and can be applied to mouse models of allergic diseases. Ovalbumin, low endotoxin can induce allergic rhinitis in mice via sensitization and nasal challenge. Ovalbumin, low endotoxin can be used to establish asthma models.
Interleukin Related   IFNAR  
Inflammation or Immune System Disease  
/
HY-W012642 2-Aminopurine
2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics.
DNA Stain  
/
HY-21170B Trifluoromethanesulfonate lithium
Trifluoromethanesulfonate (Triflate;Trifluoromethylsulfonate) lithium is a stable lithium salt and dopant with four resonance states, which is commonly used as an electrolyte component in polymer light-emitting electrochemical cells and primary lithium batteries. Trifluoromethanesulfonate lithiumalso acts as a catalyst for the preparation of the herbicide Imazapyr. In MEH-PPV-based light-emitting electrochemical cells, Trifluoromethanesulfonate lithium promotes electrochemical p-type doping at the anode interface under applied bias, thereby facilitating the formation of p-i-n junctions, exciton generation, and light emission. Trifluoromethanesulfonate lithiumexhibits strong ion pairing in non-aqueous electrolytes, but its electrochemical stability window is narrower than that of lithium bistrifluoromethylsulfonyl imidee.
Biochemical Assay Reagents   Herbicide  
/
HY-D2906 Alexa fluor 647 maleimide
Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics.
Fluorescent Dye  
/
HY-W115721 Rhodizonic acid disodium
Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits Aconitase activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures.
Reactive Oxygen Species (ROS)   DNA/RNA Synthesis  
/
HY-NP0204 MSA Protein
MSA Protein (Mouse Serum Albumin) is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD).
ELOVL   Apoptosis   NOD-like Receptor (NLR)   Caspase   Tau Protein  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-D1056A3 Lipopolysaccharides, from E. coli O26:B6
Lipopolysaccharides, from E. coli (Escherichia coli) O26:B6 are lipopolysaccharide endotoxins and TLR-4 activators derived from E. coli, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from E. coli O26:B6 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A, and can be recognized by the core-specific monoclonal antibody MAb J8-4C10. Lipopolysaccharides, from E. coli O26:B6 can promote an increase in pro-inflammatory cytokines in plasma, thereby triggering hypothalamic-pituitary-adrenal (HPA) activation and leading to adrenal oxidative damage. The pathogenic effects of Lipopolysaccharides, from E. coli O26:B6 can be used to construct various models, such as cellular inflammation models, sepsis, acute lung injury models, adrenal dysfunction models, and bladder infection models, etc.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Toll-like Receptor (TLR)  
Inflammation or Immune System Disease  
/
HY-P99797 Pabinafusp alfa
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.
Transferrin Receptor  
Neurological, Eye or Ear Disease  
/
HY-P99849 Depatuxizumab
Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer.

Species: Human

EGFR  
Cancer  
/
HY-D0904 Acetylthiocholine iodide
Acetylthiocholine iodide can be used as a substrate for certain enzymes, such as cholinesterase, etc., and can be used to determine the activity level of these enzymes. In addition, the compound is used in some medical research, for example in the fields of neuroscience and organ physiology.
Biochemical Assay Reagents  
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HY-NP163A Wheat germ agglutinin-AF488
Wheat germ agglutinin-AF488 (WGA-AF488) is a cell membrane-specific staining agent prepared by conjugating wheat germ agglutinin with the Alexa Fluor 488 (HY-D1304) fluorescent dye, and it binds to cell surface glycoproteins with high affinity. Wheat germ agglutinin-AF488 is applied in fluorescence microscopy and confocal imaging techniques, and it can clearly label the membrane structures of various cells including breast cancer cells, enabling high-resolution visual observation. Wheat germ agglutinin-AF488 is used in studies of breast cancer and triple-negative breast cancer to observe cell morphology and membrane dynamic changes.
Fluorescent Dye  
Cancer  
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HY-D1005H Poloxamer 188 (F68)
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
Environmental Pollutants   Fluorescent Dye   Biochemical Assay Reagents  
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HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery.
Biochemical Assay Reagents  
Cancer  
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HY-100355 C18-Ceramide (d18:1/18:0)
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
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HY-P70687 NCAM-1/CD56 Protein, Human (HEK293, His)
Neural cell adhesion molecule 1 (NCAM1) is a cell adhesion molecule which enables LRR domain binding activity and phosphatase binding activity. NCAM1 plays a role in the cell development and differentiation as well as immune surveillance. NCAM1 plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and activating FAK, MAPK and PI3K. NCAM-1/CD56 Protein, Human (HEK293, His) is the recombinant human-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

CD Antigens NK Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins NCAM-1/CD56

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HY-P78764 NCAM-1/CD56 Protein, Mouse (HEK293, His)
NCAM-1/CD56 protein is an important cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, and neurite outgrowth. It interacts with MDK and forms a complex with SLC39A6 and SLC39A10, complexly regulating NCAM-1 phosphorylation. NCAM-1/CD56 Protein, Mouse (HEK293, His) is the recombinant mouse-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-His, C-10*His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens NK Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins NCAM-1/CD56

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HY-P70843 NEDD8 Protein, Human
NEDD8 is an important ubiquitin-like protein that plays a key role in cell cycle regulation and embryogenesis by binding to specific proteins such as cullin and p53/TP53. Its binding to cullin is critical for recruiting E2 enzymes to the cullin-RING-based E3 ubiquitin-protein ligase complex, thereby enabling degradation of regulatory proteins. NEDD8 Protein, Human is the recombinant human-derived NEDD8 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

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HY-P700890 Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His)
Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors TGF-beta Superfamily Neurotrophic Factors TGF-β TGF-β3

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HY-P71168 NPDC-1 Protein, Human (HEK293, His)
NPDC-1 protein critically hinders oncogenic transformation in neural and non-neural cells, suppressing neural cell proliferation. Its multifaceted impact extends to transcriptional regulation, emphasizing its role as a regulator with implications for mitigating oncogenic processes and modulating cellular proliferation in diverse cell systems. NPDC-1 Protein, Human (HEK293, His) is the recombinant human-derived NPDC-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P75932 NCAM-1/CD56 Protein, Human (HEK293, His-Avi)
Neural cell adhesion molecule 1 (NCAM1) is a cell adhesion molecule which enables LRR domain binding activity and phosphatase binding activity. NCAM1 plays a role in the cell development and differentiation as well as immune surveillance. NCAM1 plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and activating FAK, MAPK and PI3K. NCAM-1/CD56 Protein, Human (HEK293, His-Avi) is the recombinant human-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Species: Human; Source: HEK293

CD Antigens NK Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins NCAM-1/CD56

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HY-P78802 Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His-Avi)
Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with C-Avi, N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His-Avi) is 389 a.a., with molecular weight of 40-45 kDa.

Species: Human; Source: HEK293

Cytokines and Growth Factors TGF-beta Superfamily Neurotrophic Factors TGF-β TGF-β3

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HY-P75281 DPP10 Protein, Human (HEK293, His)
The DPP10 protein is a key regulator that promotes cell surface expression of the potassium channel KCND2, modulating its activity and gating properties. Despite its name, DPP10 lacks dipeptidyl aminopeptidase activity. DPP10 Protein, Human (HEK293, His) is the recombinant human-derived DPP10 protein, expressed by HEK293 , with N-His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

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HY-P701026 NCAM-1/CD56 Protein, Cynomolgus (HEK293, His)
NCAM-1/CD56 protein is an important cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, and neurite outgrowth. It interacts with MDK and forms a complex with SLC39A6 and SLC39A10, complexly regulating NCAM-1 phosphorylation. NCAM-1/CD56 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-His labeled tag.

Species: Cynomolgus; Source: HEK293

CD Antigens NK Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins NCAM-1/CD56

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HY-P76278 CNTN6/Contactin-6 Protein, Human (HEK293, Fc)
The Contactin-6 (CNTN6) protein is a key player in nervous system development, promoting critical cell surface interactions. It actively participates in oligodendrocyte generation by acting as a ligand for NOTCH1. CNTN6/Contactin-6 Protein, Human (HEK293, Fc) is the recombinant human-derived CNTN6/Contactin-6 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs)

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HY-P76842 CNTN5/Contactin-5 Protein, Mouse (HEK293, His)
The CNTN5/Contactin-5 protein is a member of the contactin family and plays a crucial role in mediating cell surface interactions during nervous system development. Although it exhibits neurite growth-promoting activity in cerebral cortical neurons, it does not exhibit the same effect in hippocampal neurons, highlighting its cell type-specific function in neuronal growth. CNTN5/Contactin-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CNTN5/Contactin-5 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs)

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HY-P79307 Latent TGF-beta bp4 Protein, Human (HEK293, His)
Latent TGF-β binding protein 4 (LTBP4) plays a critical role in the TGFB1, TGFB2, and TGFB3 signaling pathways, maintaining TGF-β in a latent state during extracellular storage. LTBP4 complexly regulates integrin-dependent TGF-β activation through specific disulfide interactions with latency-associated peptide (LAP). Latent TGF-beta bp4 Protein, Human (HEK293, His) is the recombinant human-derived Latent TGF-beta bp4 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P76841 CNTN5/Contactin-5 Protein, Human (HEK293, His)
CNTN5/Contactin-5 protein mediates cell surface interactions in nervous system development, promoting neurite outgrowth in cerebral cortical neurons but not in hippocampal neurons. It is involved in auditory system neuronal activity and interacts with PTPRG, potentially regulating neuronal functions and connectivity. CNTN5/Contactin-5 Protein, Human (HEK293, His) is the recombinant human-derived CNTN5/Contactin-5 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs)

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HY-P701080 Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His)
Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Biotinylated Proteins TGF-beta Superfamily Neurotrophic Factors TGF-β TGF-β3

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HY-P703416 UfSP1 Protein, Human
UfSP1 Protein, Human is the recombinant human-derived UfSP1, expressed by E. coli , with tag Free labeled tag. ,

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P704630 Latent GDF-8 Protein, Human (CHO, His)
GDF-8 (Growth Differentiation Factor 8) functions as a specific negative regulator of skeletal muscle growth. It forms homodimers linked by disulfide bonds and inhibits WFIKKN2 activity through interaction. GDF-8 also interacts with FST3, playing a regulatory role in skeletal muscle growth modulation. GDF-8 Protein, Human (CHO, His) is the recombinant rat/mouse/human-derived GDF-8 protein, expressed by CHO, with N-His labeled tag.

Species: Human; Source: CHO

Cytokines and Growth Factors TGF-beta Superfamily Growth Differentiation Factor Growth Differentiation Factor-8 (GDF-8)

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HY-P86522 N Cadherin Antibody (YA6214)
N Cadherin Antibody (YA6214) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to N Cadherin.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83477 CD56 Antibody (YA3222)
CD56 Antibody (YA3222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD56.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811598 THOC5 Antibody
THOC5 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to THOC5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811665 NCAM2 Antibody (YA10136)
NCAM2 Antibody (YA10136) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to NCAM2.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811805 THOC5 Antibody (YA10276)
THOC5 Antibody (YA10276) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to THOC5.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811805A THOC5 Antibody (YA10276) (PBS only)
THOC5 Antibody (YA10276) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to THOC5.

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P812022 MTREX Antibody(YA10493)
MTREX Antibody(YA10493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTREX.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P812022A MTREX Antibody(YA10493) (PBS only)
MTREX Antibody(YA10493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTREX.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P84998 CD56 Antibody (YA4690)
CD56 Antibody (YA4690) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD56.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Nanobodies Primary Antibodies

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HY-P85195 HAND1 Antibody (YA4887)
HAND1 Antibody (YA4887) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HAND1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P85195A HAND1 Antibody (YA4887)(PBS only)
HAND1 Antibody (YA4887) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HAND1.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86359 SLUG Antibody (YA6051)
SLUG Antibody (YA6051) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLUG.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86767 AIMP2 Antibody (YA6460)
AIMP2 Antibody (YA6460) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AIMP2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86850 Delta-catenin Antibody (YA6543)
Delta-catenin Antibody (YA6543) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Delta-catenin.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85951 CD56 Antibody (YA5643)
CD56 Antibody (YA5643) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD56.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-K0002 Bacterial Protein Extraction Reagent

MCE Bacterial Protein Extraction Reagent integrates both lysozyme and nuclease activities and is specifically formulated for E. coli lysis. It efficiently disrupts the peptidoglycan layer under mild conditions to rapidly release intracellular proteins. Simultaneously, the incorporated nucleases degrade genomic DNA/RNA, significantly reducing lysate viscosity and minimizing nucleic-acid interference, thereby preserving the native conformation and functional integrity of target proteins to the greatest extent.

Protein Biology Protein Sample Preparation Cell Lysis

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HY-K0226 CHO Magnetic Beads (200 nm, 10 mg/mL)

MCE CHO Magnetic Beads (200 nm, 10 mg/mL) contain CHO functional groups, which react with primary amines on proteins or other molecules to form stable amide linkages，can covalently immobilize proteins for the affinity purification of antibodies, antigens and other biomolecules.

Protein Biology Protein Purification Magnetic Beads

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HY-K0227 NHS Magnetic Beads (200nm, 10 mg/mL)

MCE NHS Magnetic Beads (200 nm, 10 mg/mL) contain N-hydroxysuccinimide (NHS) functional groups, which react with primary amines on proteins or other molecules to form stable amide linkages，can covalently immobilize proteins for the affinity purification of antibodies, antigens and other biomolecules.

Protein Biology Protein Purification Magnetic Beads

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HY-K0608 Masson Staining Kit

MCE Masson Staining Kit can simultaneously stain various tissue components, such as cell nuclei, collagen fibers, and muscle fibers. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Cell Biology Cell Analysis Staining Kit

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HY-K0609 Modified Masson Staining Kit

MCE Modified Masson Staining Kit employs Celestine Blue hematoxylin for light nuclear staining, offering shorter differentiation time compared to conventional methods. It features low toxicity, environmental friendliness, simple operation, and stable performance. The staining results show clear coloration and high contrast. The stained sections can be stored for long periods with minimal fading, facilitating long-term preservation and image analysis. This kit is widely used in studies of connective tissue, muscle tissue, and collagen fibers, and is suitable for histological observation and related pathological analyses.

Cell Biology Cell Analysis Staining Kit

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HY-K3035 G-5 Supplement (100×)

MCE G-5 Supplement (100×) is a serum-free, chemically defined cell culture supplement developed based on the classic Bottenstein G-5 formulation. It is suitable for the culture of primary glial cells and neural cells with myelination properties. This supplement contains growth factors, hormones, insulin, transferrin, and other components related to cell growth and maintenance.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K6022 ECM Gentle Dissociation Solution

MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation. This product is compatible with a wide range of cell types, including stem cell colonies, primary cells, neural cells, and organoids, and is particularly well suited for gentle yet effective dissociation of brain organoids and other complex 3D structures.

Cell Biology Cell Culture 3D Cell Culture Dissociation Reagents PSC Induction Product Series

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HY-K6025 Cell Invasion Basement Membrane Matrix (Ready-to-Use)

MCE Cell Invasion Basement Membrane Matrix (Ready-to-Use) is formulated in high-glucose DMEM and contains 50 μg/mL gentamicin. With an optimized formulation and working concentration, it requires no additional dilution or preparation and can be directly used for Transwell cell invasion assays to establish an in vitro extracellular matrix barrier model for evaluating the invasive capacity and invasion potential of cells, particularly in studies of tumor cell invasion.

Cell Biology 3D Cell Culture Basement Membrane Matrix

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HY-K6026 In Vitro Angiogenesis Basement Membrane Matrix (Ready-to-Use)

MCE In Vitro Angiogenesis Basement Membrane Matrix (Ready-to-Use) is formulated in high-glucose DMEM and contains 50 μg/mL gentamicin. With an optimized formulation and working concentration, it requires no additional dilution or preparation and can be directly used for in vitro tube formation assays with HUVECs and other endothelial cells, supporting the establishment of in vitro angiogenesis models and related research.

Cell Biology 3D Cell Culture Basement Membrane Matrix

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HY-K6101A Human Breast Cancer Organoid Complete Culture Medium

MCE Human Breast Cancer Organoid Complete Culture Medium is a pre-mixed, ready-to-use formulation composed of a basal breast cancer organoid medium and multiple key culture supplements at optimized ratios. This medium requires no additional preparation and enables the efficient and stable establishment of human breast cancer organoid models.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6104A Human Colorectal Cancer Organoid Complete Culture Medium

MCE Human Colorectal Cancer Organoid Complete Culture Medium is a pre-mixed, ready-to-use formulation composed of a basal colorectal cancer organoid medium and multiple key culture supplements at optimized ratios. This medium requires no additional preparation and enables the efficient and stable establishment of human colorectal cancer organoid models.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6105A Human Gastric Cancer Organoid Complete Culture Medium

MCE Human Gastric Cancer Organoid Complete Culture Medium is a pre-mixed, ready-to-use formulation composed of a basal gastric cancer organoid medium and multiple key culture supplements at optimized ratios. This medium requires no additional preparation and enables the efficient and stable establishment of human gastric cancer organoid models.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6123A Human Ovarian Cancer Organoid Complete Culture Medium

MCE Human Ovarian Cancer Organoid Complete Culture Medium is a pre-mixed, ready-to-use formulation composed of a basal ovarian cancer organoid medium and multiple key culture supplements at optimized ratios. This medium requires no additional preparation and enables the efficient and stable establishment of human ovarian cancer organoid models.

Cell Biology 3D Cell Culture Tumor Organoid Culture Medium

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HY-K6303 Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit

MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

Cell Biology 3D Cell Culture PSC Induction Product Series

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HY-K6304 Human iPSC/ESC Hepatocyte Induction Differentiation Kit

MCE Human iPSC/ESC Hepatocyte Induction Differentiation Kit enables the efficient generation of hepatocyte-like cells with a high degree of maturation within 21 d. The resulting cells stably express multiple key hepatic functional markers, including albumin (ALB), cytochrome P450 (CYP) family enzymes, and other liver-specific functional molecules, and exhibit typical hepatocellular phenotypes and functions.

Cell Biology 3D Cell Culture PSC Induction Product Series

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HY-K6305 Human PSC Islet Organoid Differentiation Kit

MCE Human PSC Islet Organoid Differentiation Kit enables the efficient directed differentiation of human pluripotent stem cells (PSCs) into structurally intact and functionally mature islet organoids within 26 d.

Cell Biology 3D Cell Culture PSC Induction Product Series

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HY-K6504 Human iPSC/ESC Cortical Brain Organoid Maturation Medium

MCE Human iPSC/ESC Cortical Brain Organoid Maturation Medium is a ready-to-use culture system specifically formulated for the long-term maintenance and maturation of cortical brain organoids. It serves as a seamless transition from the induction phase and supports the continued growth and functional development of the organoids. Upon switching PSC-derived cortical brain organoids to this medium, organoid viability and structural stability are markedly enhanced, enabling a robust and extended culture period of up to 180 d.

Cell Biology 3D Cell Culture PSC Induction Product Series

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Keywords

artificial intelligence | joint brain-behavior modeling | brain-behavior dynamics | neural dynamics | behavioral dynamics | multimodal neural data | dynamic functional connectivity | machine learning | deep learning | pose estimation | latent neural states | dynamic dictionary learning | LSTM | neural decoding | brain-computer interface | computational neuroscience | interpretable AI