ACHE - acetylcholinesterase (Cartwright blood group) Gene

Also Known as YT; ACEE; ARACHE; N-ACHE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 43

About ACHE

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,889,994-100,896,994 (from NCBI)

This gene has 14 transcripts (splice variants), 234 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 4.6), small intestine (RPKM 3.5) and 22 other tissues.

Summary

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single AChE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and Other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The Other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion[provided by RefSeq, Sep 2019]

ACHE Products (11)

mRNA	Protein	Name
NM_001282449.2	NP_001269378.1	acetylcholinesterase isoform 3 precursor
NM_001302622.2	NP_001289551.1	acetylcholinesterase isoform E4-E6 precursor
NM_001367918.1	NP_001354847.1	acetylcholinesterase isoform 5
NM_001367919.2	NP_001354848.1	acetylcholinesterase isoform 6
NM_001367917.1	NP_001354846.1	acetylcholinesterase isoform E4-E6 precursor
NR_160407.1
NR_160408.2
NM_000665.5	NP_000656.1	acetylcholinesterase isoform E4-E6 precursor
NM_001367915.1	NP_001354844.1	acetylcholinesterase isoform E4-E6 precursor
NM_015831.2
NM_001302621.3	NP_001289550.1	acetylcholinesterase isoform E4-E5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylcholine binding	IDA IDA: Inferred from direct assay	8349597	GOA
enables acetylcholinesterase activity	IDA IDA: Inferred from direct assay	1517212	GOA
enables acetylcholinesterase activity	IMP IMP: Inferred from mutant phenotype	1517212	GOA
enables cholinesterase activity	IDA IDA: Inferred from direct assay	1517212	GOA
enables collagen binding	IDA IDA: Inferred from direct assay	12524166	GOA
enables hydrolase activity	IDA IDA: Inferred from direct assay	1517212	GOA
enables laminin binding	IDA IDA: Inferred from direct assay	12524166	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10800960	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12524166	GOA
enables serine hydrolase activity	IDA IDA: Inferred from direct assay	3954986	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acetylcholine catabolic process	IDA IDA: Inferred from direct assay	1517212	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	15454088	GOA
involved in osteoblast development	IEP IEP: Inferred from expression pattern	15454088	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15454088	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	1517212	GOA
located in membrane	IDA IDA: Inferred from direct assay	16262697	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14766237	GOA
located in synapse	IDA IDA: Inferred from direct assay	8460160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACHE Protein Structure

COesterase

AChE_tetra

0
100
200
300
400
500
614 a.a.

Protein Preferred Names	Protein Names
acetylcholinesterase	Yt blood group acetylcholinesterase (Yt blood group) apoptosis-related acetylcholinesterase

ACHE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACHE	P22303	COLQ	Homo sapiens	Q9Y215	Pull Down	15526038
Intra	ACHE	P22303	RACK1	Homo sapiens	P63244	Enzymatic Study	18194455
Intra	ACHE	P22303	RACK1	Homo sapiens	P63244	Y2H	18194455
Intra	ACHE	P22303	ENO1	Homo sapiens	P06733	Y2H	18194455
Intra	ACHE	P22303	ENO1	Homo sapiens	P06733	Enzymatic Study	18194455

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACHE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79277	Acetylcholinesterase/ACHE Protein, Human (CHO, His)	P22303-1 (E32-L614)	≥ 95%, as determined by reducing SDS-PAGE.

ACHE Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84186	ACHE Antibody (YA3883)	WB, IHC-P, FC	Human, Mouse, Monkey, Rat
HY-P84186A	ACHE Antibody (YA3883)(PBS only)	WB, IHC-P, FC	Human, Mouse, Monkey, Rat

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Nephrotic Syndrome, Type 1	Finnish Congenital Nephrosis NPHS1 Cnf Finnish Congenital Nephrotic Syndrome Nephrotic Syndrome Type 1 Nephrosis, Congenital Congenital Nephrotic Syndrome Nephrotic Syndrome, Congenital Congenital Nephrotic Syndrome Finnish Type Congenital Nephrotic Syndrome 1 Nephrosis 1, Congenital, Finnish Type Congenital Nephrotic Syndrome, Finnish Type Nephrotic Syndrome 1 Congenital Nephrotic Syndrome Of The Finnish Type
Vascular Dementia	Dementia, Vascular Multi Infarct Dementia Multifocal Dementia Dementia Vascular Vascular Dementia, Susceptibility To Dementia, Multi-Infarct Multi-Infarct Dementia
Cascade Stomach	Hourglass Stricture Or Stenosis Of Stomach Hourglass Contraction Of Stomach Hourglass Stenosis Of Stomach Hourglass Stricture Of Stomach
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Alzheimer Disease 10	Ad10 Alzheimer Disease-10 Alzheimer'S Disease 10 Alzheimer Disease, Familial, 10 Alzheimer Disease Familial 10 Alzheimer'S Disease 10, Early Onset
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Myasthenic Syndrome, Congenital, 6, Presynaptic	Familial Infantile Myasthenia CMS6 Cmsea Congenital Myasthenic Syndrome 6 Familial Infantile Myasthenia Gravis 2 Fimg2 Myasthenic Syndrome, Congenital, Associated With Episodic Apnea Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea Congenital Myasthenic Syndrome Type Ia2, Formerly Cms1a2, Formerly Cms Ia2, Formerly Myasthenia, Familial Infantile, Formerly Fim, Formerly Myasthenia Gravis, Familial Infantile, 2, Formerly Fimg2, Formerly Cms Ia2 Cms1a2 Congenital Myasthenic Syndrome 6, Presynaptic Congenital Myasthenic Syndrome Type Ia2 Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea Fim Cms1a Cms-Ea Cms Ia Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea Congenital Myasthenic Syndrome Type 1a Congenital Myasthenic Syndrome Type Ia Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Simultanagnosia
Finger Agnosia
Pupil Disease	Pupil Disorders Pupillary Disorder
Aplasia Cutis Congenita	Aplasia Cutis Congenita Of Limbs Recessive Congenital Absence Of Skin On The Upper Or Lower Limbs Recessive Aplasia Cutis Congenita Of The Limbs Aplasia Cutis Congenita Nonsyndromic Congenital Defect Of Skull And Scalp Scalp Defect Congenital
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Congenital Ptosis	Congenital Blepharoptosis Congenital Eyelid Ptosis
Neuromuscular Junction Disease	Neuromuscular Junction Diseases
Neurogenic Bowel
Functional Colonic Disease	Colonic Diseases, Functional
Cerebrovascular Disease	Cerebrovascular Accident Cerebrovascular Disorder Cerebrovascular Disorders Cva Stroke
Diabetes Mellitus	Diabetes
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Spina Bifida Aperta	Open Spina Bifida Spina Bifida Without Hydrocephalus Spina Bifida Manifesta Spina Bifida Aperta With Tethered Spinal Cord
Mild Cognitive Impairment
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Congenital Myasthenic Syndrome	Congenital Myasthenia Congenital Myasthenic Syndromes Cms Myasthenic Syndromes, Congenital Myasthenic Syndromes Congenital Myasthenic Syndrome, Congenital Congenital Myasthenic Syndrome Ib Congenital And Developmental Myasthenia Developmental Myasthenia
Myopathy	Muscular Diseases Myopathies
Yt Blood Group Antigen	Cartwright Antigen
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Movement Disease	Movement Disorders Movement Disorder
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Developmental And Epileptic Encephalopathy 47	DEE47 Epileptic Encephalopathy, Early Infantile, 47 Eiee47 Developmental And Epileptic Encephalopathy, 47 Early Infantile Epileptic Encephalopathy 47
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Gastroschisis	Laparoschisis Congenital Fissure Of The Abdominal Cavity Abdominal Wall Defect Abdominal Hernia Hernia, Abdominal Omphalocele Abnormality Of The Abdominal Wall Congenital Omphalocele Coeloschisis Coelioschisis Celoschisis Congenital Para-Umbilical Hernia
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Persian Gulf Syndrome	Gulf War Syndrome
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Wernicke-Korsakoff Syndrome	Korsakoff Syndrome Transketolase Defect Korsakoff'S Syndrome Alcohol-Induced Encephalopathy Korsakoff'S Psychosis Korsakov Psychosis Korsakov'S Psychosis Alcohol Induced Encephalopathy Korsakoff Disease Korsakoff Psychosis
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Constipation
Epilepsy, Familial Temporal Lobe, 2	Familial Temporal Lobe Epilepsy 2 Temporal Epilepsy, Familial ETL2 Ftle Epilepsy, Familial Temporal Lobe Familial Temporal Lobe Epilepsy
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Congenital Megacolon Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against Hirschsprung'S Disease Congenital Intestinal Aganglionosis HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Paroxysmal Nocturnal Hemoglobinuria	Marchiafava-Micheli Disease Pnh Hemoglobinuria, Paroxysmal Marchiafava-Micheli Syndrome Paroxysmal Hemoglobinuria Nocturnal Nocturnal Haemoglobinuria Nocturnal Paroxysmal Haematuria Nocturnal Paroxysmal Haemoglobinaemia
Pure Autonomic Failure	Orthostatic Hypotension Idiopathic Orthostatic Hypotension Postural Hypotension Bradbury-Eggleston Syndrome Bradbury Eggleston Syndrome Hypotension, Orthostatic Hypotension, Postural Paf Pure Dysautonomia Pure Idiopatic Dysautonomia Hypotension Orthostatic Primary Orthostatic Hypotension Chronic Orthostatic Hypotension
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Alzheimer Disease 12	Ad12 Alzheimer'S Disease 12 Alzheimer Disease, Familial, 12 Alzheimer Disease Familial 12
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Acute Laryngopharyngitis	Pharyngolaryngitis Laryngopharyngitis Hypopharyngitis
Thiamine Deficiency Disease
Omphalocele	Omphalocoele Congenital Omphalocele Exomphalos Exumbilication
Colonic Pseudo-Obstruction	Primary Chronic Pseudo-Obstruction Of Colon
Polyneuropathy	Polyneuropathies
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Megacolon	Dilatation Of Colon
Rem Sleep Behavior Disorder	Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behavior Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Myasthenic Syndrome, Congenital, 5	Endplate Acetylcholinesterase Deficiency Congenital Myasthenic Syndrome 5 CMS5 Ead Engel Congenital Myasthenic Syndrome Myasthenic Syndrome, Congenital, Engel Type Cms Ic Congenital Myasthenic Syndrome Type Ic Congenital Myasthenic Syndrome Type Ic, Formerly Cms1c, Formerly Cms Ic, Formerly Congenital Myasthenic Syndrome Engel Type End Plate Acetylcholinesterase Deficiency Synaptic Congenital Myasthenic Syndromes Cms1c Cmse Congenital Myasthenic Syndrome Type 1c End-Plate Acetylcholinesterase Deficiency Myasthenic Syndrome, Congenital, Type 5
Myasthenia Gravis	MG Acquired Myasthenia Autoimmune Myasthenia Gravis Erb-Goldflam Disease Mg - [Myasthenia Gravis] Myasthenia Gravis Nos Myasthenia
Binswanger'S Disease	Multi-Infarct Dementia Dementia Multi-Infarct Binswanger Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0034	Donepezil Hydrochloride	Inhibitor	99.92%	Yes
HY-14566	Donepezil	Inhibitor	99.87%	Yes
HY-17368	Rivastigmine	Inhibitor	99.95%	Yes
HY-76299	Galanthamine	Inhibitor	99.90%	Yes
HY-11017	Rivastigmine tartrate	Inhibitor	99.03%	Yes
HY-B0207A	Pyridostigmine bromide	Inhibitor	98.86%	Yes
HY-17387	(-)-Huperzine A	Inhibitor	99.95%	Yes
HY-B1488	Tacrine hydrochloride	Inhibitor	99.90%	Unkown
HY-107922	Ethopropazine hydrochloride	Inhibitor	99.32%	Unkown
HY-B1266	Physostigmine salicylate	Inhibitor	99.74%	Unkown
HY-111338	Tacrine	Inhibitor	99.10%	Yes
HY-B0364A	Dyclonine hydrochloride	Inhibitor	99.12%	Unkown
HY-A0009	Galanthamine hydrobromide	Inhibitor	99.93%	Yes
HY-B0884A	Minaprine dihydrochloride	Inhibitor	99.90%	Unkown
HY-B1200	Pralidoxime chloride	Activator	99.98%	Unkown
HY-B0732	Itopride hydrochloride	Inhibitor	99.84%	Unkown
HY-B0882	Edrophonium chloride	Inhibitor	98.68%	Unkown
HY-100919	Ambenonium chloride	Inhibitor	96.18%	Yes
HY-B1738A	Pralidoxime iodide	Activator	98.0%	Unkown
HY-B2244	Tacrine hydrochloride hydrate	Inhibitor	99.98%	Unkown
HY-B2155	Acotiamide monohydrochloride trihydrate	Inhibitor	99.79%	Yes
HY-B1738	Pralidoxime	Activator	≥90.0%	Unkown
HY-B0884	Minaprine	Inhibitor	/	Unkown
HY-114899	Azamethiphos	Inhibitor	98.10%	Unkown
HY-B0732A	Itopride	Antagonist	/	Unkown
HY-B0949A	Protriptyline	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103374	Phenserine	Inhibitor	99.55%	Phase 3
HY-B0916	Propoxur	Inhibitor	99.43%	Phase 3
HY-127165	Velnacrine	Inhibitor	98.79%	Phase 3
HY-19651	Zanapezil free base	Inhibitor	99.23%	Phase 3
HY-114422	p38α-IN-13	Inhibitor	/	Phase 3
HY-105157A	Icopezil maleate	Inhibitor	/	Phase 2
HY-135427	Quilostigmine	Inhibitor	/	Phase 2
HY-106412A	Stacofylline hydrochloride	Inhibitor	/	Phase 2
HY-106440	Zifrosilone	Inhibitor	/	Phase 2
HY-117710B	AD-35	Inhibitor	/	Phase 2
HY-180141	AF03	Activator	/	Phase 1
HY-108048	Desoxypeganine	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (398)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108477	TMPyP4 tosylate	Inhibitor	98.0%	Unkown
HY-N0285	Imperatorin	Inhibitor	98.59%	Unkown
HY-107569	Garcinol	Inhibitor	98.85%	Unkown
HY-138097	α-NETA	Inhibitor	≥98.0%	Unkown
HY-B0815	Chlorpyrifos	Inhibitor	99.94%	Unkown
HY-N0528	Linarin	Inhibitor	98.02%	Unkown
HY-N0342	Scopoletin	Inhibitor	99.89%	Unkown
HY-N0226A	Epiberberine chloride	Inhibitor	98.68%	Unkown
HY-N0286	Isoimperatorin	Inhibitor	99.78%	Unkown
HY-N5077	Sinapine	Inhibitor	99.94%	Unkown
HY-N0825	Nodakenin	Inhibitor	98.70%	Unkown
HY-N0826	Corynoline	Inhibitor	98.84%	Unkown
HY-N0810	Timosaponin AIII		99.86%	Unkown
HY-N0923	Corydaline	Inhibitor	99.70%	Unkown
HY-W017423	(-)-Carvone	Inhibitor	99.91%	Unkown
HY-N0740	Jatrorrhizine chloride	Inhibitor	99.82%	Unkown
HY-75247	Coumaran	Inhibitor	99.67%	Unkown
HY-N4142	Cyanidin-3-O-galactoside chloride	Inhibitor	99.20%	Unkown
HY-Y0504	Trimethylammonium chloride	Inhibitor	98.0%	Unkown
HY-N0450	Sinapine thiocyanate	Inhibitor	99.85%	Unkown
HY-W159754	Chavicol	Inhibitor	97.99%	Unkown
HY-21629	N-Boc-4-piperidinemethanol		99.91%	Unkown
HY-N2320	Physostigmine hemisulfate	Inhibitor	99.80%	Unkown
HY-N2230	N-p-trans-Coumaroyltyramine	Inhibitor	99.28%	Unkown
HY-N0631	Cornuside	Inhibitor	99.99%	Unkown
HY-N2081	Skimmianine	Inhibitor	99.93%	Unkown
HY-106901A	Asoxime dichloride	Inhibitor	98.47%	Unkown
HY-Y0504S3	Trimethylammonium chloride-d9	Inhibitor	99.65%	Unkown
HY-B0832	Profenofos	Inhibitor	96.07%	Unkown
HY-B0841	Acephate	Inhibitor	98.0%	Unkown
HY-N0859	Schisanhenol	Inhibitor	99.99%	Unkown
HY-N1474	Picfeltarraenin IA	Inhibitor	99.85%	Unkown
HY-N0702	Tenuifolin	Inhibitor	99.73%	Unkown
HY-N4225	Aaptamine	Inhibitor	99.71%	Unkown
HY-N0241	Rhodionin	Inhibitor	99.73%	Unkown
HY-122140	ACG548B	Inhibitor	99.72%	Unkown
HY-W130025	p-Xylene bispyridinium bromide	Inhibitor	99.60%	Unkown
HY-N6895	Violanthin	Inhibitor	98.27%	Unkown
HY-135761	Penconazole	Inhibitor	98.91%	Unkown
HY-100620	RPR121056	Inhibitor	99.88%	Unkown
HY-N2425	Rhodiosin	Inhibitor	99.07%	Unkown
HY-B2015	Carbosulfan	Inhibitor	98.0%	Unkown
HY-NP192	Sericin	Antagonist	0%	Unkown
HY-17388	(±)-Huperzine A	Inhibitor	98.73%	Unkown
HY-N2511	Trimyristin	Modulator	99.72%	Unkown
HY-N4119	Neoeriocitrin	Inhibitor	99.97%	Unkown
HY-N0749A	Jatrorrhizine hydroxide	Inhibitor	98.06%	Unkown
HY-B1881	Pirimiphos-methyl	Inhibitor	98.39%	Unkown
HY-I0020	Galanthaminone	Inhibitor	99.85%	Unkown
HY-124957	β-NETA	Inhibitor	98.0%	Unkown
HY-118165	Phenthoate	Inhibitor	98.71%	Unkown
HY-N2157	Pteryxin	Inhibitor	99.55%	Unkown
HY-N3270	Methyl orsellinate	Inhibitor	99.91%	Unkown
HY-W014700	Glycyl-L-glutamic acid	Modulator	99.89%	Unkown
HY-34408	6-Methoxy-1-tetralone		99.89%	Unkown
HY-122203	PCS1055 dihydrochloride	Inhibitor	98.88%	Unkown
HY-N7612	N-Desmethyl Galanthamine	Inhibitor	99.60%	Unkown
HY-N7993	Manghaslin	Inhibitor	98.76%	Unkown
HY-P2616A	Mca-YVADAP-Lys(Dnp)-OH TFA	Chemical	98.29%	Unkown
HY-W016188	1-Naphthyl acetate		99.89%	Unkown
HY-N0801	Polygalacic acid	Inhibitor	98.92%	Unkown
HY-B0835	Fenobucarb	Inhibitor	98.62%	Unkown
HY-W017765	1,1'-Bi-2-naphthol	Inhibitor	99.94%	Unkown
HY-P4279	Ovalbumin (154-159)		99.18%	Unkown
HY-W130236	Methylene Violet 3RAX	Inhibitor	95.54%	Unkown
HY-W278867	trans-3,5-Dimethoxystilbene	Inhibitor	98.45%	Unkown
HY-N2211	Picfeltarraenin IB	Inhibitor	98.53%	Unkown
HY-B0830	Isoprocarb	Inhibitor	99.12%	Unkown
HY-B1093	Fenchlorphos	Inhibitor	99.95%	Unkown
HY-10399A	Ladostigil hydrochloride	Inhibitor	99.91%	Unkown
HY-119419	Pirimicarb	Inhibitor	99.50%	Unkown
HY-N18343	Ebelin lactone	Inhibitor	96.0%	Unkown
HY-107275	Ebeiedinone	Inhibitor	99.90%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.78%	Unkown
HY-155140	BChE-IN-17	Inhibitor	99.07%	Unkown
HY-N4191	Isorosmanol	Inhibitor	99.66%	Unkown
HY-121072	ASS234	Inhibitor	99.6%	Unkown
HY-122203A	PCS1055	Inhibitor	98.02%	Unkown
HY-164130	AChE-IN-65	Inhibitor	/	Unkown
HY-119979	Cardanol monoene		99.51%	Unkown
HY-115910A	Y13g dihydrochloride	Inhibitor	99.89%	Unkown
HY-N5120	Dihydrowithaferin A	Inhibitor	99.72%	Unkown
HY-119577	Ubretid		99.0%	Yes
HY-B2029	Phosalone	Inhibitor	98.04%	Unkown
HY-B1120	Temephos	Inhibitor	99.35%	Unkown
HY-114803	Kokusaginine	Inhibitor	98%	Unkown
HY-B0830S	Isoprocarb-d3	Inhibitor	99.95%	Unkown
HY-N2176A	(±)-Marmesin		95.0%	Unkown
HY-N7263	Galanthamine N-Oxide	Inhibitor	99.90%	Unkown
HY-110389	Pitofenone hydrochloride	Inhibitor	99.88%	Unkown
HY-N0749	Jatrorrhizine	Inhibitor	/	Unkown
HY-151368	AChE/BChE-IN-10	Inhibitor	99.67%	Unkown
HY-N12581	Kuwanon U	Inhibitor	97.30%	Unkown
HY-19651A	Zanapezil	Inhibitor	99.63%	Unkown
HY-103373	PE154	Inhibitor	99.01%	Unkown
HY-N0226	Epiberberine	Inhibitor	98.46%	Unkown
HY-N10488	BChE-IN-11	Inhibitor	98.78%	Unkown
HY-Z8890	Norneostigmine	Inhibitor	98.93%	Unkown
HY-N1989	Bacoside A	Modulator	/	Unkown
HY-105327	P11149	Inhibitor	99.23%	Unkown
HY-149212	SD-6	Inhibitor	≥98.0%	Unkown
HY-19651B	Zanapezil fumarate	Inhibitor	99.63%	Unkown
HY-W550259	Coroxon	Inhibitor	/	Unkown
HY-N7346	Lucidadiol	Inhibitor	98.0%	Unkown
HY-126765	Territrem B	Inhibitor	≥95.0%	Unkown
HY-W004287	Methyl tridecanoate	Inhibitor	99.75%	Unkown
HY-Y0504S4	Trimethylammonium chloride-d6	Inhibitor	99.35%	Unkown
HY-134137	Donepezil N-oxide	Inhibitor	99.9%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-178017	BChE/hCA II-IN-1	Inhibitor	/	Unkown
HY-106901B	Asoxime dimesylate	Inhibitor	/	Unkown
HY-118222	KBR 2822	Inhibitor	/	Unkown
HY-148412	Monarsen	Inhibitor	/	Unkown
HY-144272	AChE-IN-5	Inhibitor	/	Unkown
HY-178141	AChE/BuChE-IN-7	Inhibitor	/	Unkown
HY-170561	AChE/BuChE-IN-6	Inhibitor	/	Unkown
HY-N11641	Methyl ganoderate A acetonide	Inhibitor	/	Unkown
HY-144389	hAChE/Aβ1-42-IN-1	Inhibitor	/	Unkown
HY-174328	BChE/AChE-IN-1	Inhibitor	/	Unkown
HY-180891	Multitarget AD-IN-4	Inhibitor	/	Unkown
HY-N18289	8-Hydroxydihydrochelerythrine	Inhibitor	/	Unkown
HY-N10423	Cubebin	Inhibitor	/	Unkown
HY-161512	hAChE/hBACE-1-IN-4	Inhibitor	/	Unkown
HY-158695	Dual AChE-MAO B-IN-4	Inhibitor	/	Unkown
HY-172461	MAO-IN-6	Inhibitor	/	Unkown
HY-W165085	1,10-Bis(pyridinium)decane	Inhibitor	99.66%	Unkown
HY-180892	Multi-kinase-IN-10	Inhibitor	/	Unkown
HY-158092	ChEs/MAOs-IN-2	Inhibitor	/	Unkown
HY-175474	AChE-IN-93	Inhibitor	/	Unkown
HY-173152	AChE/BChE-IN-26	Inhibitor	/	Unkown
HY-161508	AChE/BChE-IN-19	Inhibitor	/	Unkown
HY-143291	AChE-IN-9	Inhibitor	/	Unkown
HY-182290	AChE/BChE-IN-36	Inhibitor	/	Unkown
HY-149300	SB-1436	Inhibitor	/	Unkown
HY-106412	Stacofylline	Inhibitor	/	Unkown
HY-149237	hAChE-IN-2	Inhibitor	/	Unkown
HY-155085	hAChE-IN-3	Inhibitor	/	Unkown
HY-169962	hCA I-IN-4	Inhibitor	/	Unkown
HY-N11962A	2,3,9,10-Tetrahydroxyberberine bromide	Inhibitor	/	Unkown
HY-174462	AChE-IN-90	Inhibitor	/	Unkown
HY-170417	hAChE/hBuChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-178750	AChE-IN-96	Inhibitor	/	Unkown
HY-158978	Multitarget AD inhibitor-2	Inhibitor	/	Unkown
HY-115910	Y13g	Inhibitor	/	Unkown
HY-162693	AChE-IN-68	Inhibitor	/	Unkown
HY-105853	Pitofenone	Inhibitor	/	Unkown
HY-163909	AChE-IN-72	Inhibitor	/	Unkown
HY-175973	AChE/BChE-IN-30	Inhibitor	/	Unkown
HY-162933	AChE-IN-77	Inhibitor	/	Unkown
HY-N19855	Merulinic acid	Inhibitor	/	Unkown
HY-180358	Gallamine	Inhibitor	/	Unkown
HY-W800535	Cryptolepine	Inhibitor	/	Unkown
HY-180946	AChE-IN-105	Inhibitor	/	Unkown
HY-B0916R	Propoxur (Standard)	Inhibitor	99.04%	Unkown
HY-174381	BChE-IN-41	Inhibitor	/	Unkown
HY-147870	COX-2-IN-22	Inhibitor	/	Unkown
HY-115973	AChE-IN-11	Inhibitor	/	Unkown
HY-184140	AChE-IN-117	Inhibitor	/	Unkown
HY-170925	AChE-IN-81	Inhibitor	/	Unkown
HY-134006	Stemoninine	Inhibitor	/	Unkown
HY-180819	AChE/BChE-IN-33	Inhibitor	/	Unkown
HY-181744	AChE-IN-108	Inhibitor	/	Unkown
HY-175524	BChE/MAO-B-IN-2	Inhibitor	/	Unkown
HY-149087	MR2938	Inhibitor	/	Unkown
HY-181503	AChE/BuChE-IN-8	Inhibitor	/	Unkown
HY-162681	eeAChE-IN-3	Inhibitor	/	Unkown
HY-N15452	Eseramine	Inhibitor	/	Unkown
HY-149211	AChE/BChE-IN-12	Inhibitor	/	Unkown
HY-174464	AChE/BChE-IN-28	Inhibitor	/	Unkown
HY-157441	AChE/Aβ-IN-4	Inhibitor	/	Unkown
HY-161507	hCAI/II-IN-8	Inhibitor	/	Unkown
HY-161311	AChE/BChE-IN-18	Inhibitor	/	Unkown
HY-168241	Flucopride	Inhibitor	/	Unkown
HY-N12388	AChE-IN-46	Inhibitor	/	Unkown
HY-150728	AChE-IN-22	Inhibitor	/	Unkown
HY-108048A	Desoxypeganine hydrochloride	Inhibitor	/	Unkown
HY-175523	MAO-B-IN-48	Inhibitor	/	Unkown
HY-180842	MAO-B-IN-50	Inhibitor	/	Unkown
HY-Y0504S1	Trimethylammonium chloride-d10	Inhibitor	98.0%	Unkown
HY-162812	H3R antagonist 4	Inhibitor	/	Unkown
HY-W750970	2-Acetoxyacorenone	Inhibitor	/	Unkown
HY-174419	TFSeB	Inhibitor	/	Unkown
HY-N19871	Monogynol A	Inhibitor	/	Unkown
HY-157440	AChE/Aβ-IN-3	Inhibitor	/	Unkown
HY-107272	Chuanbeinone	Inhibitor	/	Unkown
HY-184791	AChE-IN-120	Inhibitor	/	Unkown
HY-178943	Neuroprotective agent 15	Inhibitor	/	Unkown
HY-131971	AChE/BChE-IN-1	Inhibitor	/	Unkown
HY-172884	MDAR-IN-1	Inhibitor	/	Unkown
HY-N17425	Lakoochin C	Inhibitor	/	Unkown
HY-144392	AChE/BuChE-IN-1	Inhibitor	/	Unkown
HY-180146	BChE-IN-48	Inhibitor	/	Unkown
HY-157982	BChE-IN-28	Inhibitor	/	Unkown
HY-N2898	Artanin	Inhibitor	≥90.0%	Unkown
HY-Y0504S	Trimethylammonium chloride-13c3,d9	Inhibitor	98%	Unkown
HY-N21823	Methyl isoplatydesmine	Inhibitor	/	Unkown
HY-146762	MAO-B-IN-7	Inhibitor	/	Unkown
HY-180113	AChE-IN-100	Inhibitor	/	Unkown
HY-N17775	Scutellarein 4'-methyl ether 7-O-glucuronide	Inhibitor	/	Unkown
HY-172460	AChE/BChE/MAO-B-IN-5	Inhibitor	/	Unkown
HY-174399	AChE/BChE-IN-27	Inhibitor	/	Unkown
HY-N10701	AChE/BChE-IN-11	Inhibitor	/	Unkown
HY-N2511S	Trimyristin--d15	Modulator	/	Unkown
HY-180552	AChE-IN-104	Inhibitor	/	Unkown
HY-184776	Dyclonine	Inhibitor	/	Unkown
HY-180243	AChE-IN-102	Inhibitor	/	Unkown
HY-N12423	Bis-(-)-8-demethylmaritidine	Inhibitor	/	Unkown
HY-B0916S	Propoxur-d3	Inhibitor	/	Unkown
HY-135450	Dimefluthrin		/	Unkown
HY-162591	MR33317	Inhibitor	/	Unkown
HY-145235	AChE-IN-4		/	Unkown
HY-N10781	Isograndifoliol	Inhibitor	/	Unkown
HY-181110	MAO-A-IN-4	Inhibitor	/	Unkown
HY-146035	AChE-IN-14	Inhibitor	/	Unkown
HY-169163	BChE-IN-36	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-168731	AChE/BChE-IN-25	Inhibitor	/	Unkown
HY-101653	MHP 133	Inhibitor	/	Unkown
HY-159880	AChE/BChE-IN-24	Inhibitor	/	Unkown
HY-168603	AChE/CA I-IN-1	Inhibitor	/	Unkown
HY-175006	AChE-IN-91	Inhibitor	/	Unkown
HY-165341	SCR1693	Inhibitor	/	Unkown
HY-175658	AChE/BChE-IN-29	Inhibitor	/	Unkown
HY-151152	AChE-IN-24	Inhibitor	/	Unkown
HY-122080	Memoquin	Inhibitor	/	Unkown
HY-149233	hAChE-IN-1	Inhibitor	/	Unkown
HY-W746884	2-Methyl-2-butenyl (E)-Caffeate	Inhibitor	/	Unkown
HY-159116	AChE-IN-69	Inhibitor	/	Unkown
HY-N8547A	(Rac)-Sclerone	Inhibitor	/	Unkown
HY-119292	AP2238	Inhibitor	/	Unkown
HY-168052	hAChE-IN-9	Inhibitor	/	Unkown
HY-127087	Isogarcinol	Inhibitor	/	Unkown
HY-163441	BChE-IN-31	Inhibitor	/	Unkown
HY-115919	AChE-IN-8	Inhibitor	/	Unkown
HY-181161	AChE-IN-107	Inhibitor	/	Unkown
HY-144790	AChE-IN-12	Inhibitor	/	Unkown
HY-144388	ChE/Aβ1-42-IN-1	Inhibitor	/	Unkown
HY-155284	K1833	Inhibitor	/	Unkown
HY-181861	AChE/MAO-B-IN-9	Inhibitor	/	Unkown
HY-157981	AChE-IN-60	Inhibitor	/	Unkown
HY-W053641	(E)-2-Nitrocinnamic acid	Inhibitor	/	Unkown
HY-149272	tau/Aβ40 aggregation-IN-1	Inhibitor	/	Unkown
HY-152111	AChE/MAO-B-IN-3	Inhibitor	/	Unkown
HY-120131	Cyanofenphos	Inhibitor	/	Unkown
HY-175300	AChE-IN-92	Inhibitor	/	Unkown
HY-179711	AChE/BChE-IN-32	Inhibitor	/	Unkown
HY-151260	AChE/BACE1/GSK3β-IN-1	Inhibitor	/	Unkown
HY-180225	AChE-IN-101	Inhibitor	/	Unkown
HY-184279	JDS364	Activator	/	Unkown
HY-165281	Chondrocurine	Inhibitor	/	Unkown
HY-180155	Keap1/Nrf2/ARE activator 2	Inhibitor	/	Unkown
HY-W585905	Trimethylammonium chloride-13C3	Inhibitor	/	Unkown
HY-Y0504S2	Trimethylammonium chloride-15N	Inhibitor	/	Unkown
HY-177798	AChE-IN-98	Inhibitor	/	Unkown
HY-155714	AChE-IN-35	Inhibitor	/	Unkown
HY-157532	AChE-IN-55	Inhibitor	/	Unkown
HY-183303	AChE-IN-116	Inhibitor	/	Unkown
HY-162915	AChE-IN-75	Inhibitor	/	Unkown
HY-147846	AChE/PDE4-IN-1	Inhibitor	/	Unkown
HY-159898	AChE/BChE-IN-23	Inhibitor	/	Unkown
HY-181445	NSC 620023 TFA	Inhibitor	/	Unkown
HY-159482	SBN-284	Inhibitor	/	Unkown
HY-152232	BChE-IN-15	Inhibitor	/	Unkown
HY-103374B	(±)Phenserine	Inhibitor	/	Unkown
HY-B0364AS	Dyclonine-d9 hydrochloride	Inhibitor	/	Unkown
HY-181865	BuChE-IN-22	Inhibitor	/	Unkown
HY-N16715	Monardic acid A	Inhibitor	/	Unkown
HY-151562	AChE/BuChE/MAO-B-IN-1	Inhibitor	/	Unkown
HY-143252	CEase-IN-1	Inhibitor	/	Unkown
HY-149287	hAChE/hBACE-1-IN-1	Inhibitor	/	Unkown
HY-184159	AChE/BChE/MAO-A-IN-2	Inhibitor	/	Unkown
HY-161842	AChE-IN-67	Inhibitor	/	Unkown
HY-132903	eeAChE-IN-1	Inhibitor	/	Unkown
HY-157437	AChE/BChE-IN-16	Inhibitor	/	Unkown
HY-162338	BChE-IN-29	Inhibitor	/	Unkown
HY-155366	hAChE-IN-6	Inhibitor	/	Unkown
HY-163537	AChE/BuChE-IN-5	Inhibitor	/	Unkown
HY-173144	AChE-IN-85	Inhibitor	/	Unkown
HY-N15710	Magnotriol B	Inhibitor	/	Unkown
HY-161156	BChE-IN-26	Inhibitor	/	Unkown
HY-N16645	Plasiaticine B	Inhibitor	/	Unkown
HY-183341	sEH/AChE-IN-5		/	Unkown
HY-N9846	Luteolin 5,3'-dimethyl ether		/	Unkown
HY-184796	AChE-IN-119	Inhibitor	/	Unkown
HY-132904	eeAChE-IN-2	Inhibitor	/	Unkown
HY-105157	Icopezil	Inhibitor	/	Unkown
HY-149288	hAChE/hBACE-1-IN-2	Inhibitor	/	Unkown
HY-151927	AChE-IN-28	Inhibitor	/	Unkown
HY-W856819	Eseroline	Inhibitor	/	Unkown
HY-161150	AChE/BChE-IN-17	Inhibitor	/	Unkown
HY-N17416	ω-Hydroxydigitoemodin	Inhibitor	/	Unkown
HY-181851	AChE-IN-109	Inhibitor	/	Unkown
HY-157296	AChE-IN-47	Inhibitor	/	Unkown
HY-183796	GFAP/NF-κB/APOE/NLRP3-IN-1	Inhibitor	/	Unkown
HY-170583	hAChE-IN-10	Inhibitor	/	Unkown
HY-151885	Dual AChE-MAO B-IN-3	Inhibitor	/	Unkown
HY-186298	Brassicasteryl linoleate	Inhibitor	/	Unkown
HY-146663A	AChE/BChE-IN-3 hydrochloride	Inhibitor	/	Unkown
HY-161243	AChE-IN-56	Inhibitor	/	Unkown
HY-146959	K203	Activator	/	Unkown
HY-181248	BChE-IN-49	Inhibitor	/	Unkown
HY-N10384	AChE-IN-17	Inhibitor	/	Unkown
HY-184742	AJ-4	Inhibitor	/	Unkown
HY-155713	AChE-IN-34	Inhibitor	/	Unkown
HY-N15707	Isocorydine N-oxide	Inhibitor	/	Unkown
HY-163126	AChE-IN-52	Inhibitor	/	Unkown
HY-149273	hBChE-IN-1	Inhibitor	/	Unkown
HY-144762	K027	Inhibitor	/	Unkown
HY-181141	AChE/MAO-B-IN-8	Inhibitor	/	Unkown
HY-182786	MAO-B-IN-56	Inhibitor	/	Unkown
HY-143465	BChE-IN-5	Inhibitor	/	Unkown
HY-181119	AChE-IN-106	Inhibitor	/	Unkown
HY-152110	AChE/MAO-IN-2	Inhibitor	/	Unkown
HY-49373	AChE-IN-64	Inhibitor	/	Unkown
HY-175758	AChE-IN-94	Inhibitor	/	Unkown
HY-157978	AChE-IN-59	Inhibitor	/	Unkown
HY-169961	BChE-IN-38	Inhibitor	/	Unkown
HY-144689	BChE-IN-3	Inhibitor	/	Unkown
HY-177958	ACS03	Activator	/	Unkown
HY-155822	TZ3O	Inhibitor	98.17%	Unkown
HY-N16739	Circumdatin C	Inhibitor	/	Unkown
HY-179496	ChE/GSK-3β-IN-1	Inhibitor	/	Unkown
HY-169162	hBChE-IN-3	Inhibitor	/	Unkown
HY-163514	hAChE-IN-8	Inhibitor	/	Unkown
HY-181041	Multitarget AD-IN-5	Inhibitor	/	Unkown
HY-147952	AChE-IN-20	Inhibitor	/	Unkown
HY-N21822	(+)-(R)-Ribalinine	Inhibitor	/	Unkown
HY-N21824	(+)-(3S)-ψ-Ribalinine	Inhibitor	/	Unkown
HY-181167	AChE/BChE-IN-34	Inhibitor	/	Unkown
HY-161142	Carbonic anhydrase/AChE-IN-1	Inhibitor	/	Unkown
HY-N10032	(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol	Inhibitor	/	Unkown
HY-156372	AChE-IN-44	Inhibitor	/	Unkown
HY-152113	AChE/BChE/MAO-B-IN-3	Inhibitor	/	Unkown
HY-157382	AChE-IN-51	Inhibitor	/	Unkown
HY-182333	AChE-IN-112	Inhibitor	/	Unkown
HY-150545	AChE-IN-21	Inhibitor	/	Unkown
HY-170389	BChE-IN-39	Inhibitor	/	Unkown
HY-179621	EQ-04	Modulator	/	Unkown
HY-170938	AChE-IN-82	Inhibitor	/	Unkown
HY-162606	MAO-A/B-IN-3	Inhibitor	/	Unkown
HY-170560	AChE/hCA I-IN-1	Inhibitor	/	Unkown
HY-179122	BChE-IN-45	Inhibitor	/	Unkown
HY-115841	Isatin-O	Activator	/	Unkown
HY-184935	Neuroprotective agent 18	Inhibitor	/	Unkown
HY-182001	Multi-kinase-IN-13	Inhibitor	/	Unkown
HY-183760	AChE/BChE-IN-37	Inhibitor	/	Unkown
HY-N16447	Territrem C		/	Unkown
HY-19181	CI-1002	Antagonist	/	Unkown
HY-N2219	Picfeltarraegenin X	Inhibitor	/	Unkown
HY-158261	AChE-IN-63	Inhibitor	/	Unkown
HY-147938	AChE-IN-19	Inhibitor	/	Unkown
HY-182254	AChE/BChE-IN-35	Inhibitor	/	Unkown
HY-152109	AChE/MAO-IN-1	Inhibitor	/	Unkown
HY-157087	AChE/MAO-B-IN-4	Inhibitor	/	Unkown
HY-159081	AChE/BChE-IN-20	Inhibitor	/	Unkown
HY-172219	CUR-IPA	Inhibitor	/	Unkown
HY-181811	PJ17	Inhibitor	/	Unkown
HY-149090	AChE/BuChE/MAO-B-IN-2		/	Unkown
HY-147939	AChE/BuChE-IN-3	Inhibitor	/	Unkown
HY-180114	NSS-18	Inhibitor	/	Unkown
HY-176439	AChE-IN-88	Inhibitor	/	Unkown
HY-175856	AChE-IN-95	Inhibitor	/	Unkown
HY-152112	AChE/BChE/MAO-B-IN-2	Inhibitor	/	Unkown
HY-183949	Insecticidal agent 33	Inhibitor	/	Unkown
HY-178433	BChE/p38-α MAPK-IN-2	Inhibitor	/	Unkown
HY-145695	Dual AChE-MAO B-IN-1	Inhibitor	/	Unkown
HY-146315	AChE/BChE-IN-6	Inhibitor	/	Unkown
HY-185347	AChE-IN-114	Inhibitor	/	Unkown
HY-162036	α-Amylase/α-Glucosidase-IN-7	Inhibitor	/	Unkown
HY-162639	α-Glucosidase-IN-68	Inhibitor	/	Unkown
HY-180783	AChE/BChE/MAO-A-IN-1	Inhibitor	/	Unkown
HY-123887	Manumycin B	Inhibitor	/	Unkown
HY-181597	LINS05414	Inhibitor	/	Unkown
HY-144775	AChE-IN-10	Inhibitor	/	Unkown
HY-113905	ZINC12613047	Inhibitor	/	Unkown
HY-112013	Isodimethoate	Inhibitor	/	Unkown
HY-183066	AChE-IN-115	Inhibitor	/	Unkown
HY-18039	WAY-361789	Agonist	/	Unkown
HY-161029	T14-A24	Inhibitor	/	Unkown
HY-165600	Trimedoxime dichloride	Activator	/	Unkown
HY-N19401	Vescalagin	Inhibitor	/	Unkown
HY-W588214	Phorate sulfone	Inhibitor	/	Unkown
HY-W332450	Demeton-S	Inhibitor	/	Unkown
HY-117710A	AD-35 free base	Inhibitor	/	Unkown
HY-116041	Anabasamine	Inhibitor	/	Unkown
HY-120042	Heptenophos	Inhibitor	/	Unkown
HY-180506	Tyrosinase-IN-47	Inhibitor	/	Unkown
HY-169173	AL284	Inhibitor	/	Unkown
HY-N12833	Dihydrokaempferol-3-O-β-D-glucoside	Inhibitor	/	Unkown
HY-183403	Ganstigmine	Inhibitor	/	Unkown
HY-W049312	7-Methoxytacrine	Inhibitor	/	Unkown
HY-175607	AChE/nAChR-IN-1	Inhibitor	/	Unkown
HY-180448	Galactamine	Inhibitor	/	Unkown
HY-N1151	Thunberginol C	Inhibitor	/	Unkown
HY-W740798	4'-O-Methylcatechin	Inhibitor	/	Unkown
HY-N2971	Buxbodine B	Inhibitor	/	Unkown
HY-115650	TAE-1	Inhibitor	96.17%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992076	Anti-Candida auris β-1, 3 glucans Antibody (2G8)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ACHE	VGNC	VGNC:80325
Felis catus	ACHE	VGNC	VGNC:80549
Canis familiaris	ACHE	VGNC	VGNC:49076
Mus musculus	ACHE	MGD	MGI:87876
Rattus norvegicus	ACHE	RGD	RGD:69313
Others	ACHE	NCBI