Ache - acetylcholinesterase Gene
Species: Mus musculus
About Ache
This gene has 9 transcripts (splice variants), 234 orthologues, 25 paralogues and is associated with 50 phenotypes. Broad expression in cerebellum adult (RPKM 25.6), thymus adult (RPKM 23.5) and 19 other tissues.
Summary
Enables several functions, including acetylcholinesterase activity; identical protein binding activity; and protein self-association. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including acetylcholine catabolic process; acetylcholine receptor signaling pathway; and regulation of receptor recycling. Located in several cellular components, including basement membrane; cell surface; and neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human AChE (acetylcholinesterase (Cartwright blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Ache Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_009599.4 | NP_033729.1 | acetylcholinesterase precursor |
| NM_001290010.1 | NP_001276939.1 | acetylcholinesterase precursor |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables acetylcholinesterase activity |
IDA
IDA: Inferred from direct assay
|
7512968 | MGI |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
8626792 | MGI |
| enables laminin binding |
IPI
IPI: Inferred from physical interaction
|
15474030 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20053883 | MGI |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| acts upstream of or within acetylcholine catabolic process |
IDA
IDA: Inferred from direct assay
|
7512968 | MGI |
| acts upstream of or within acetylcholine receptor signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
14645660 | MGI |
| involved in positive regulation of cold-induced thermogenesis |
IMP
IMP: Inferred from mutant phenotype
|
17038428 | MGI |
| acts upstream of or within receptor internalization |
IMP
IMP: Inferred from mutant phenotype
|
14645660 | MGI |
| acts upstream of or within regulation of receptor recycling |
IMP
IMP: Inferred from mutant phenotype
|
14645660 | MGI |
| acts upstream of or within retina development in camera-type eye |
IMP
IMP: Inferred from mutant phenotype
|
15579149 | MGI |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in basement membrane |
IDA
IDA: Inferred from direct assay
|
7885444 | MGI |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
16434405 | MGI |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
8626792 | MGI |
| located in neuromuscular junction |
IDA
IDA: Inferred from direct assay
|
7885444 | MGI |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
8626792 | MGI |
| located in synapse |
IDA
IDA: Inferred from direct assay
|
10995443 | MGI |
Ache Protein Structure
COesterase: pfam00135 (36 - 562)
AChE_tetra: pfam08674 (577 - 610)
- 0
- 100
- 200
- 300
- 400
- 500
- 614 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
acetylcholinesterase |
|
Recombinant Ache Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P72811 | Acetylcholinesterase/ACHE Protein, Mouse (HEK293, His) | P21836-1/NP_033729.1 (E32-L614) | ≥ 95%, as determined by reducing SDS-PAGE. |
Ache Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P810614 | Acetylcholinesterase Antibody (YA9876) | WB, IHC-F, IHC-P | Mouse, Rat |
| HY-P86779 | Acetylcholinesterase Antibody (YA6472) | WB, IHC-F | Mouse, Rat |