2. Gene
  3. Bcl2 - B cell leukemia/lymphoma 2 Gene

Bcl2 - B cell leukemia/lymphoma 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik

Gene ID: 12043 | Gene type: protein coding

About Bcl2

Chromosome 1: 106,465,908-106,642,004 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 133 phenotypes. Ubiquitous expression in spleen adult (RPKM 4.5), limb E14.5 (RPKM 2.8) and 23 other tissues.

Summary

This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated Apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and Autophagy. Abnormal expression and chromosomal translocations of this gene are associated with Cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Bcl2 Products(2)

mRNA Protein Name
NM_177410.3 NP_803129.2 apoptosis regulator Bcl-2 isoform 2
NM_009741.5 NP_033871.2 apoptosis regulator Bcl-2 isoform 1

Bcl2 Protein Structure

bcl-2

bcl-2: TIGR00865 (10 - 235)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

apoptosis regulator Bcl-2

Recombinant Bcl2 Proteins

Cat. No. Product Name Accession Purity
HY-P72101 BCL2 Protein, Mouse (His) P10417 (G5-P205) ≥95%

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15531 Venetoclax 99.95% Yes
HY-B0011 Docetaxel 99.91% Unkown
HY-B0318 Metronidazole 99.92% Yes
HY-13407 Gossypol Antagonist 99.56% Yes
HY-17510 Gossypol (acetic acid) Inhibitor 99.17% Yes
HY-B0011A Docetaxel Trihydrate 99.92% Unkown
HY-118874 Oblimersen / Unkown
HY-B0318A Metronidazole hydrochloride / Unkown
HY-B0011R Docetaxel (Standard) / Unkown
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-105930 Lobaplatin ≥98.0% Phase 4
HY-10087 Navitoclax Inhibitor 99.97% Phase 3
HY-10969 Obatoclax Mesylate 99.74% Phase 3
HY-10969A Obatoclax / Phase 3
HY-50868 Bafetinib 99.77% Phase 2
HY-109185 Pelcitoclax 95.53% Phase 2
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-129179 Lisaftoclax Inhibitor 99.28% Phase 2
HY-138697 S65487 99.10% Phase 2
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
HY-138697B S65487 hydrochloride 99.67% Phase 2
HY-123823 Nitroaspirin / Phase 2
HY-138697A S65487 sulfate 98.08% Phase 2
HY-117288 S55746 Inhibitor 99.89% Phase 1
Pre-clinical Phase
Bioactive Molecules (179)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50907 ABT-737 99.96% Unkown
HY-107738 Guggulsterone 99.95% Unkown
HY-112416 AZD4320 Inhibitor 99.68% Unkown
HY-N0674 Dehydrocorydaline 99.77% Unkown
HY-N2342 Procyanidin C1 99.79% Unkown
HY-N0087 Gambogic Acid 98.79% Unkown
HY-130604 DT2216 99.97% Unkown
HY-18628 UMI-77 Inhibitor 99.66% Unkown
HY-126477 NNK 99.98% Unkown
HY-N0292 Oleuropein 99.05% Unkown
HY-N0361 Dihydrocapsaicin 99.86% Unkown
HY-125877 PROTAC Mcl1 degrader-1 Inhibitor 98.13% Unkown
HY-103243 TCPOBOP Inhibitor 98.67% Unkown
HY-N3584 Paris saponin VII 99.96% Unkown
HY-N0265 Asperosaponin VI Inhibitor 98.91% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 98.78% Unkown
HY-118119 CAY10526 Inhibitor 99.40% Unkown
HY-12020 TW-37 Inhibitor 99.27% Unkown
HY-15191 Sabutoclax Inhibitor 99.80% Unkown
HY-133557 XZ739 99.06% Unkown
HY-N2897 Dihydrokaempferol 99.88% Unkown
HY-15531S Venetoclax-d8 99.76% Unkown
HY-33350 Clofilium tosylate 99.84% Unkown
HY-N0674A Dehydrocorydaline chloride 99.72% Unkown
HY-N0674B Dehydrocorydaline (hydroxyl) 99.77% Unkown
HY-139309 PROTAC Bcl-xL degrader-2 Inhibitor 98.16% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.12% Unkown
HY-12011 HA14-1 Inhibitor ≥98.0% Unkown
HY-138832 BM-1244 Inhibitor 98.77% Unkown
HY-120882 BM-1197 Inhibitor 99.43% Unkown
HY-148026 Sonrotoclax Inhibitor 99.51% Unkown
HY-N3001 Isolinderalactone Inhibitor 98.79% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 99.86% Unkown
HY-16014 A-385358 Inhibitor 98.19% Unkown
HY-117288A S55746 hydrochloride Inhibitor 99.66% Unkown
HY-100383 BH3I-1 ≥98.0% Unkown
HY-109184 Murizatoclax Inhibitor 98.85% Unkown
HY-142209 ABBV-167 Inhibitor 97.33% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-10087S Navitoclax-d8 Inhibitor 99.71% Unkown
HY-N6690 Destruxin B 99.86% Unkown
HY-P1889 Bim BH3, Peptide IV 99.51% Unkown
HY-N4238 Dehydrocorydaline nitrate 99.90% Unkown
HY-N1440 Koumine 99.97% Unkown
HY-111329 JGB1741 99.05% Unkown
HY-119931 2-Hydroxychalcone 98.80% Unkown
HY-13408 (+)-Apogossypol Inhibitor / Unkown
HY-15464D (S)-Gossypol (acetic acid) Inhibitor 98.39% Unkown
HY-156278 FB49 Inhibitor 99.76% Unkown
HY-157176 BAX-IN-1 ≥98.0% Unkown
HY-B0011S Docetaxel-d9 ≥98.0% Unkown
HY-N0307 Ciwujianoside B Inhibitor 99.00% Unkown
HY-N1157 Thevetiaflavone ≥98.0% Unkown
HY-N2416 Taccalonolide A 99.29% Unkown
HY-P2343 BH3 hydrochloride Activator 98.02% Unkown
HY-109617 4-(4-Fluorophenyl)benzoic acid 99.01% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-128360 dMCL1-2 Inhibitor / Unkown
HY-131188 PROTAC Bcl-xL degrader-1 Inhibitor / Unkown
HY-131247 Bcl-2-IN-2 Inhibitor / Unkown
HY-135273 A-1211212 / Unkown
HY-155188 NWP-0476 Inhibitor / Unkown
HY-100762 Mcl1-IN-11 Inhibitor / Unkown
HY-100763 Mcl1-IN-12 Inhibitor / Unkown
HY-118874A Oblimersen sodium Inhibitor / Unkown
HY-146097 RMS5 / Unkown
HY-149918 Antiproliferative agent-23 / Unkown
HY-156620 Lacutoclax Inhibitor / Unkown
HY-18106 BM 957 Inhibitor / Unkown
HY-113471A (S)-(-)-Perillic acid / Unkown
HY-115974 GRPR antagonist-1 Antagonist / Unkown
HY-119833 Rubone Modulator / Unkown
HY-121934 BH3I-2' / Unkown
HY-125191 BRD1991 Inhibitor / Unkown
HY-127130 Spicamycin / Unkown
HY-129179B (Rac)-Lisaftoclax Inhibitor 97.84% Unkown
HY-129701 MCL-1/BCL-2-IN-3 Inhibitor 99.22% Unkown
HY-129702 MCL-1/BCL-2-IN-4 Inhibitor / Unkown
HY-133772 Venetoclax N-oxide / Unkown
HY-13659 KRN5500 / Unkown
HY-13846 BM-1074 / Unkown
HY-143235 BRD4 Inhibitor-15 / Unkown
HY-143872 Bcl-2-IN-4 Inhibitor / Unkown
HY-143873 Bcl-2-IN-5 Inhibitor / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-144778 IDO1/TDO-IN-1 / Unkown
HY-144791 Bcl-2-IN-6 / Unkown
HY-144792 Bcl-2-IN-7 / Unkown
HY-145288 Antitumor agent-36 / Unkown
HY-145289 Antitumor agent-37 / Unkown
HY-146095 p53 Activator 2 / Unkown
HY-146253 CDK1/2/4-IN-1 / Unkown
HY-146444 Anticancer agent 56 / Unkown
HY-146471 EGFR-IN-51 / Unkown
HY-146472 EGFR-IN-52 / Unkown
HY-146817 Tubulin polymerization-IN-11 / Unkown
HY-147504 Anticancer agent 63 / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-147906 Anticancer agent 71 / Unkown
HY-147928 Apoptotic agent-2 / Unkown
HY-147929 Apoptotic agent-3 / Unkown
HY-149009 Bcl-2-IN-9 / Unkown
HY-149024 VEGFR-2-IN-23 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-149622 Bcl-2-IN-12 Inhibitor / Unkown
HY-149623 Bcl-2-IN-13 Inhibitor / Unkown
HY-149624 Bcl-2-IN-14 / Unkown
HY-149625 Bcl-2-IN-15 Inhibitor / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-150540 Bcl-2-IN-10 / Unkown
HY-150596 CT1-3 / Unkown
HY-151428 Antitumor agent-78 / Unkown
HY-151429 Antitumor agent-77 / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-153494 Rosomidnar Inhibitor / Unkown
HY-153494A Rosomidnar sodium Inhibitor / Unkown
HY-153953 Bcl-2-IN-11 Inhibitor / Unkown
HY-155242 VEGFR-2-IN-36 / Unkown
HY-156096 HDAC3-IN-2 / Unkown
HY-156877 Bcl-2-IN-16 / Unkown
HY-157343 GD3 Ganglioside / Unkown
HY-160108 Bcl-2-IN-17 Inhibitor / Unkown
HY-161100 BDM19 Inducer / Unkown
HY-161254 ATPase-IN-3 99.89% Unkown
HY-161276 BFC1108 Inducer / Unkown
HY-162148 HNPMI Inhibitor / Unkown
HY-163077 Anticancer agent 175 Inducer / Unkown
HY-163308 Bcl-2-IN-18 Inhibitor / Unkown
HY-163309 Bcl-2-IN-19 Inhibitor / Unkown
HY-163435 Anticancer agent 201 / Unkown
HY-18628S UMI-77-d4 Inhibitor / Unkown
HY-50907S ABT-737-d8 99.11% Unkown
HY-B0011AS Docetaxel-d5 trihydrate / Unkown
HY-N0361S Dihydrocapsaicin-d3 / Unkown
HY-N10091 2,3-Dihydro-3α-methoxynimbolide / Unkown
HY-N10481 Aviculin / Unkown
HY-N2741 Vitexin B-1 Inhibitor / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-N7930 Crenulatin ≥99.0% Unkown
HY-N8579 Eugenyl benzoate / Unkown
HY-P10057 cpm-1285 Inducer / Unkown
HY-P10058 cpm-1285m / Unkown
HY-P1527 Bim BH3 / Unkown
HY-P1733 BMf-BH3 / Unkown
HY-P1889A Bim BH3, Peptide IV TFA / Unkown
HY-P5324 Bad BH3 (mouse) / Unkown
HY-P5325 Bid BH3 (80-99) / Unkown
HY-P5327 r8 Bid BH3 / Unkown
HY-RS01415 BCL2 Human Pre-designed siRNA Set A / Unkown
HY-RS01416 Bcl2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01417 BCL2 Rat Pre-designed siRNA Set A / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01424 BCL2L10 Human Pre-designed siRNA Set A / Unkown
HY-RS01425 Bcl2l10 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01426 Bcl2l10 Rat Pre-designed siRNA Set A / Unkown
HY-RS01427 BCL2L11 Human Pre-designed siRNA Set A / Unkown
HY-RS01428 Bcl2l11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01429 Bcl2l11 Rat Pre-designed siRNA Set A / Unkown
HY-RS01430 BCL2L12 Human Pre-designed siRNA Set A / Unkown
HY-RS01431 BCL2L13 Human Pre-designed siRNA Set A / Unkown
HY-RS01432 BCL2L14 Human Pre-designed siRNA Set A / Unkown
HY-RS01433 BCL2L15 Human Pre-designed siRNA Set A / Unkown
HY-RS01434 BCL2L2 Human Pre-designed siRNA Set A / Unkown
HY-RS01435 Bcl2l2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01436 Bcl2l2 Rat Pre-designed siRNA Set A / Unkown
HY-101083A (Rac)-BDA-366 Inhibitor / Unkown
HY-15191B (S)-Sabutoclax Inhibitor 95.66% Unkown
HY-101083 BDA-366 / Unkown
HY-19551 Apogossypolone / Unkown
HY-B1559 Allethrin / Unkown
HY-N1218 Stellasterol / Unkown
HY-N1930 (-)-Hinesol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2 NCBI NCBI:596
Rattus norvegicus Bcl2 NCBI NCBI:24224