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Src homology region 2 (SH-2) domain-containing phosphatase 1

" in MedChemExpress (MCE) Product Catalog:

1392

Inhibitors & Agonists

4

Screening Libraries

50

Fluorescent Dyes

63

Biochemical Assay Reagents

165

Peptides

5

MCE Kits

71

Inhibitory Antibodies

160

Natural
Products

523

Recombinant Proteins

39

Isotope-Labeled Compounds

491

Antibodies

6

Click Chemistry

45

Oligonucleotides

8

GMP Molecules

Targets Recommended:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-13818
    Stattic
    Maximum Cited Publications
    280 Publications Verification

    		 STAT Apoptosis Inflammation/Immunology Cancer
    Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) [1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3 [2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice .
    Stattic
  • HY-P2818
    Alkaline phosphatase, Bovine intestine
    1 Publications Verification

    Apase

    		 Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial Infection Inflammation/Immunology
    Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation [1] [2] .
    Alkaline phosphatase, Bovine intestine
  • HY-19776
    3α-Aminocholestane
    5+ Cited Publications

    		 Phosphatase Cancer
    3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM.
    3α-Aminocholestane
  • HY-101053
    Src Inhibitor 1
    15+ Cited Publications

    Src Kinase Inhibitor 1; Src-l1

    		 Src Cancer
    Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.
    Src Inhibitor 1
  • HY-12299
    WH-4-023
    5 Publications Verification

    Dual LCK/Src inhibitor

    		 Src Cancer
    WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.
    WH-4-023
  • HY-108599
    DCP-LA
    5+ Cited Publications

    FR236924

    		 PKC CaMK Phosphatase Apoptosis Neurological Disease
    DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( 2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis [1] [2] .
    DCP-LA
  • HY-P2818E
    Alkaline Phosphatase, Calf intestinal
    1 Publications Verification

    Apase, Calf intestinal

    		 Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial Infection Inflammation/Immunology
    Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase, Calf intestinal is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline Phosphatase, Calf intestinal reduces myeloperoxidase activity and bacterial translocation. Alkaline Phosphatase, Calf intestinal improves survival rate of mice infected with E. coli. Alkaline Phosphatase, Calf intestinal improves TNBS-induced colon inflammation [1] [2] .
    Alkaline Phosphatase, Calf intestinal
  • HY-153992
    STAT6-IN-3
    1 Publications Verification

    		 STAT Inflammation/Immunology
    STAT6-IN-3 is a phosphopeptide mimic targeting the SH2 domain of STAT6 and has a high affinity for STAT6 (IC50: 0.04 μM). STAT6-IN-3 can be used in the research of inflammation such as asthma [1].
    STAT6-IN-3
  • HY-108543
    NSC 95397
    5+ Cited Publications

    		 Phosphatase Apoptosis Cancer
    NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) [1]. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway [2].
    NSC 95397
  • HY-164607
    YL-5092

    		DNA/RNA Synthesis Apoptosis Cancer
    YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC50 of 7.4 nM and a KD of 29.6 nM. YL-5092 can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1].
    YL-5092
  • HY-N1549
    Prunin
    4 Publications Verification

    Naringenin 7-0-glucoside

    		 Enterovirus Phosphatase Infection Metabolic Disease
    Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM [1] [2].
    Prunin
  • HY-18685
    CPDA

    		Phosphatase Metabolic Disease
    CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.
    CPDA
  • HY-W040256
    Acid phosphatase, wheat

    ACP

    		 Endogenous Metabolite Metabolic Disease Cancer
    Acid phosphatase, wheat (ACP) is a hydrolase enzyme found in wheat. Acid phosphatase, wheat catalyses the hydrolysis of orthophosphate monoesters under acidic conditions [1].
    Acid phosphatase, wheat
  • HY-W017132
    2,4-PDCA

    		MOFs Histone Demethylase Cancer
    2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics [1] [2] .
    2,4-PDCA
  • HY-P3279
    EPQpYEEIPIYL
    1 Publications Verification

    		 Src Cancer
    EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains [1] [2].
    EPQpYEEIPIYL
  • HY-112647
    Stafib-1
    1 Publications Verification

    		 STAT Cancer
    Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM [1].
    Stafib-1
  • HY-W035137
    5,15-Diphenylporphyrin

    5,15-DPP

    		 STAT Cancer
    5,15-Diphenylporphyrin (5,15-DPP) is an inhibitor of the oncogenic transcription factor STAT3. 5,15-Diphenylporphyrin specifically binds to the SH2 domain of STAT3, blocking the pTyr-SH2 interaction, thereby inhibiting the dimerization, nuclear translocation and DNA binding activity of STAT3, and ultimately inhibiting the expression of cancer cell-related genes. 5,15-Diphenylporphyrin can be used in research fields related to the development of anticancer drugs[1][2].
    5,15-Diphenylporphyrin
  • HY-130514
    SMAPP1

    		HIV CDK Infection
    SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus [1].
    SMAPP1
  • HY-151577
    STAT3-SH2 domain inhibitor 1

    		STAT Apoptosis Cancer
    STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer [1].
    STAT3-SH2 domain inhibitor 1
  • HY-N2521
    Tetramethylcurcumin

    FLLL31

    		 STAT Apoptosis Inflammation/Immunology Cancer
    Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects [1] [2].
    Tetramethylcurcumin
  • HY-129800
    CGP78850
    2 Publications Verification

    		 ERK Cancer
    CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer [1].
    CGP78850
  • HY-146127A
    Grb2 SH2 domain inhibitor 1 TFA

    		Src Others
    Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.
    Grb2 SH2 domain inhibitor 1 TFA
  • HY-E70373
    λ Protein phosphatase

    		Biochemical Assay Reagents Others
    λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn 2+. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase [1]
    λ Protein phosphatase
  • HY-146127
    Grb2 SH2 domain inhibitor 1

    		MEK Cancer
    Grb2 SH2 domain inhibitor 1 is an inhibitor of the Grb2 SH2 domain with an IC50 of 0.40 μM. Grb2 SH2 domain inhibitor 1 is also a cell-permeable cyclic peptide that can enter the cytosol of mammalian cells. Grb2 SH2 domain inhibitor 1 downregulates the expression level of p-MEK. Grb2 SH2 domain inhibitor 1 can be used in the research of breast cancer [1].
    Grb2 SH2 domain inhibitor 1
  • HY-D1208
    Alkaline phosphatase substrate

    		Biochemical Assay Reagents Phosphatase Others
    Alkaline phosphatase substrate is a chemiluminescent substrate for alkaline phosphatase. Alkaline phosphatase substrate can be used for enzyme-linked immunoassays [1].
    Alkaline phosphatase substrate
  • HY-108488
    KB SRC 4

    		Src Cancer
    KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.
    KB SRC 4
  • HY-168929
    SHP1 activator 1

    		SHP1 Fluorescent Dye Phosphatase STAT Apoptosis Cancer
    SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent [1].
    SHP1 activator 1
  • HY-124644
    1E7-03

    		HIV Phosphatase Infection
    1E7-03, a low MW tetrahydroquinoline derivative targeting protein phosphatase-1, can inhibit HIV-1 transcription [1].
    1E7-03
  • HY-P10665
    pYEEI

    		Src Cancer
    pYEEI is a phosphotyrosine-containing tetrapeptide binds to Src SH2 domain with the Kd of 100 nM and with the IC50 of 6.5 μM. pYEEI plays an important role in cancer research [1].
    pYEEI
  • HY-P5464
    SRC-1 NR box peptide

    		Estrogen Receptor/ERR Others
    SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands [1].
    SRC-1 NR box peptide
  • HY-163469
    SRC-3-IN-2

    		Src Cancer
    SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity [1].
    SRC-3-IN-2
  • HY-156914
    IGF-1R/SRC-IN-1

    		IGF-1R Src Cancer
    IGF-1R/SRC-IN-1 (Compound 3b) is an inhibitor for IGF-1R (IC50 is 63 μM) and SRC [1].
    IGF-1R/SRC-IN-1
  • HY-N12613
    Sydowimide A

    		SHP1 Phosphatase Inflammation/Immunology
    Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC50 values of 1.5, 2.4 and 18.83 μM, respectively [1].
    Sydowimide A
  • HY-E70360
    Acid Phosphatase (ACP), Sweet Potato

    Non-prostatic acid phosphatase, ACP, Orthophosphoric-monoester phosphohydrolase acid optimum, Acid phosphatase, AcPase, Apase

    		 Others Others
    Acid Phosphatase (ACP), Sweet Potato (Non-prostatic acid phosphatase, ACP, Orthophosphoric-monoester phosphohydrolase acid optimum, Acid Phosphatase, AcPase, Apase) is a biological material or organic compound that can be used in life science research [1] [2].
    Acid Phosphatase (ACP), Sweet Potato
  • HY-168187
    Src Inhibitor 3

    		Src Cancer
    Src Inhibitor 3 (Compound 7d) is a Src inhibitor with an IC50 of 285 nM. Src Inhibitor 3 inhibits HepG2 cells proliferative with an IC50 of 1.55 μM [1].
    Src Inhibitor 3
  • HY-19820
    NSC45586

    		Akt Ser/Thr Protease Neurological Disease Cancer
    NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons [1].
    NSC45586
  • HY-P0200
    RR-SRC

    		Src Inflammation/Immunology
    RR-SRC is a substrate for src-tyrosine-specific protein kinase [1].
    RR-SRC
  • HY-P1377A
    Caffeic acid-pYEEIE TFA
    1 Publications Verification

    		 Src Neurological Disease Inflammation/Immunology Cancer
    Caffeic acid-pYEEIE TFA, a phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain [1].
    Caffeic acid-pYEEIE TFA
  • HY-P5464A
    SRC-1 NR box peptide acetate

    		Estrogen Receptor/ERR Endocrinology
    SRC-1 NR box peptide acetate is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide acetate can be used to study the regulatory mechanisms of estrogen receptor ligands [1].
    SRC-1 NR box peptide acetate
  • HY-P3743
    p60c-src Substrate

    		Src Others Others
    p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides [1] [2].
    p60c-src Substrate
  • HY-P3773
    p60c-src substrate II

    		Src Cancer
    p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase pp60c-src [1].
    p60c-src substrate II
  • HY-N4143
    Cyanidin 3-arabinoside

    		Phosphatase Metabolic Disease
    Cyanidin 3-arabinoside is a selective and reversible protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC50 of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes [1].
    Cyanidin 3-arabinoside
  • HY-RS13749
    SRC Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SRC Human Pre-designed siRNA Set A
    SRC Human Pre-designed siRNA Set A
  • HY-123394
    AP-22161

    		Src Metabolic Disease
    AP22161 is a potent and selective Src SH2 domain inhibitor with an IC50 of 0.24 µM. AP22161 exhibits >120-fold selectivity over Yes SH2 (IC50 = 29.38 µM) and ZAP SH2 (IC50 = 421.86 µM). AP22161 inhibits Src-dependent cellular activity and diminishes osteoclast resorptive activity. AP22161 can be used for osteoporosis research [1].
    AP-22161
  • HY-125064
    AP22408

    		Src Cancer
    AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy [1].
    AP22408
  • HY-158774
    TG2-179-1

    		Apoptosis Cancer
    TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research [1].
    TG2-179-1
  • HY-163468
    SRC-3-IN-1

    		Src Cancer
    SRC-3-IN-1 (compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor (IC50=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research [1].
    SRC-3-IN-1
  • HY-P1377
    Caffeic acid-pYEEIE

    		Src Inflammation/Immunology
    Caffeic acid-pYEEIE, a phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain [1].
    Caffeic acid-pYEEIE
  • HY-P11443
    SRC2-2 peptide

    		Androgen Receptor Cancer
    SRC2-2 peptide is a a coactivator-derived mimic targeting androgen receptor (AR) ligand. SRC2-2 peptide is promising for research of prostate cancer [1].
    SRC2-2 peptide
  • HY-16906
    T338C Src-IN-2

    		Src Cancer
    T338C Src-IN-2 is a mutant c-Src kinase inhibitor, with an IC50 of 317 nM against T338C c-Src, 57 nM against T338C/V323A c-Src, and 19 nM against T338C/V323S c-Src. T338C Src-IN-2 inhibits the kinase activity of endogenous cysteine gatekeeper MOK. T338C Src-IN-2 reduces global phosphotyrosine levels in v-Src-ES1-transformed NIH-3T3 cells [1].
    T338C Src-IN-2

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