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Glycosylation Regulates Cell Adhesion

Intercellular Communication & Diseases Tumor Microenvironment Chronic Inflammation Proteostasis

Glycosylation is the enzyme-directed addition and remodeling of carbohydrate structures on proteins and lipids in the endoplasmic reticulum and Golgi apparatus. Unlike nucleic-acid or protein sequences, glycans are not copied from a direct template; their final structures reflect substrate availability, glycosyltransferases, glycosidases, trafficking, and cell state. Cell-surface glycans regulate adhesion by changing receptor folding, stability, clustering, conformation, and recognition by carbohydrate-binding proteins. This control is fundamental to development, epithelial organization, leukocyte trafficking, fertilization, and tissue repair. Research has expanded from structural carbohydrate chemistry to glycoproteomics and glycoengineering because altered glycosylation accompanies inflammation, congenital disorders, infection, and cancer. The same adhesion protein can therefore behave differently when its glycan occupancy, branching, fucosylation, or sialylation changes[1][2].

Several mechanisms connect glycosylation to physical attachment. Selectins recognize specialized sialylated and fucosylated glycoconjugates on leukocytes, enabling tethering and rolling on vascular endothelium under flow before integrin-dependent arrest. N-linked glycans can alter integrin and cadherin trafficking, surface retention, and lateral organization, thereby changing cell-matrix and cell-cell adhesion. Glycosylation of CD44 modifies its binding to hyaluronan, demonstrating that a receptor’s carbohydrate state can gate ligand recognition. Mucin-type O-glycans create extended surface structures that present or mask adhesion epitopes, while galectins crosslink glycoproteins into membrane lattices. These effects are context-specific: removing one glycan may strengthen one interaction, weaken another, or cause misfolding before the receptor reaches the surface[1][2][3][4].

Disease applications center on inflammation and metastasis. Selectin ligands guide immune-cell recruitment, so blocking a defined selectin-glycan interaction may reduce pathological trafficking without suppressing every leukocyte function. Cancer cells remodel N- and O-glycans, selectin ligands, cadherins, integrins, and mucins to alter detachment, vascular adhesion, immune recognition, and colonization of distant tissue. Glycan signatures can support biomarkers, while therapeutic strategies include glycosyltransferase or glycosidase inhibitors, antibodies and lectin-like binders, selectin antagonists, and glycoengineered immune cells. However, glycosylation is ubiquitous and many enzymes act on numerous substrates. A phenotype attributed to one adhesion receptor must be distinguished from simultaneous changes in growth-factor signaling, membrane organization, and protein quality control[3][4][5].

The main gap is assigning a specific glycan structure to a specific protein and adhesive function in living tissue. Lectin staining reports motif classes but rarely identifies the carrier protein or complete glycan. Future studies should combine site-resolved glycoproteomics, glycosyltransferase editing, structural analysis, adhesion assays under physiological force, and rescue with defined glycoforms. Spatial profiling must capture heterogeneity across tumor cells, endothelium, fibroblasts, and immune cells, while longitudinal sampling should test whether glycan remodeling causes invasion or follows it. Measurements should also distinguish receptor abundance from glycan-dependent changes in receptor organization, ligand affinity, and force resistance. Comparative models can determine whether a candidate glycoform is conserved across species, disease stages, and tissue niches. Drug development requires tissue-selective delivery and biomarkers that confirm alteration of the intended glycoform rather than global glycosylation stress. Mapping enzyme, glycosylation site, glycan structure, receptor organization, ligand, and mechanical outcome in one causal chain will turn descriptive cancer and inflammation signatures into precise adhesion targets[1][2][3][4][5].

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Cat. No. Product Name Information Application Publication
HY-N0162 Luteolin
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells.
Keap1-Nrf2   Apoptosis   Autophagy   Endogenous Metabolite  
Lung Cancer   Colorectal Cancer   Ovarian Cancer   Digestive System Inflammation   Glucose Metabolism   Obesity  
96
HY-14596 Genistein
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
EGFR   Autophagy   Apoptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Lung Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation   SARS-CoV-2 Infection   Hepatitis C Virus Infection   Obesity  
94
HY-L016 Protein Tyrosine Kinase Compound Library
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1,688 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Signaling Pathway Targeting Libraries

84
HY-L112 Chemotherapy Drug Library
Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs. Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 158 chemotherapy drugs, which is a useful tool for cancer treatment research.

Disease Focused Libraries

83
HY-L132 Chemokine Compound Library
Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system. The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases. MCE supplies a unique collection of 256 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.

Signaling Pathway Targeting Libraries

83
HY-L135 Cancer Stem Cells Compound Library
With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on. Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment. MCE supplies a unique collection of 3,524 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

Compound Characteristic Classified Libraries

83
HY-L226 Posttranslational Modification Library
Post-translational modifications (PTMs) refer to chemical modifications that occur on amino acid residues of proteins after translation, involving the addition or removal of specific functional groups. These modifications regulate protein activity, localization, folding, and interactions with other biomolecules. By influencing protein function, PTMs play a crucial role in various pathophysiological processes. Common types of PTMs include protein phosphorylation, methylation, acetylation, ubiquitination, glycosylation, and more. MCE offers 3,693 PTM-targeting compounds, which can be used for drug screening in cancer, neurodegenerative diseases, metabolic disorders, etc.
83
HY-L228 Lipid Metabolite Compound Library
Lipids are important energy storage substances in the human body. They are involved in the regulation of cell structure and function, as well as signaling pathways and gene expression. Abnormal lipid levels in tissues or their dysregulation can lead to various diseases. These include obesity, type 2 diabetes, non-alcoholic fatty liver disease, neurodegenerative diseases, infections, and cancer. Therefore, maintaining normal levels of lipid metabolism is critical to overall health. One of the key features of cancer is aberrant lipid metabolism. This includes alterations in lipid uptake, lipid desaturation, neolipogenesis, lipid droplets, and fatty acid oxidation in cancer cells. These changes all contribute to cellular survival in an ever-changing microenvironment. They do this by modulating feed-forward oncogenic signals and key oncogenic functions. Additionally, they affect oxidative stress, other types of stress, immune responses, and intercellular communication. Alterations in lipid metabolism have a strong impact on the properties of cancer stem cells. This includes aspects such as self-renewal, differentiation, invasion, metastasis, drug sensitivity, and resistance. Furthermore, these alterations also modulate T cell responses. MCE can offer 146 metabolites of lipid metabolism pathways, which can be used for drug screening in cancer, immune-based diseases, metabolic diseases, and other diseases.

Metabolism Focused Libraries

83
HY-L234 Nucleotide Metabolite Compound Library
Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs. MCE can provide 83 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.

Metabolism Focused Libraries

83
HY-16141 Cilengitide
Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC50 values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors.
Integrin   TGF-β Receptor   Apoptosis   PD-1/PD-L1   STAT   Akt   mTOR  
Melanoma   Glioblastoma  
75
HY-P0023A Cyclo(-RGDfK) TFA
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
Integrin  
32
HY-P0023 Cyclo(-RGDfK)
Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
Integrin  
Cancer  
32
HY-B0633A Hyaluronic acid
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer.
Endogenous Metabolite   Bacterial   Akt   PI3K  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   SARS-CoV-2 Infection  
21
HY-100506 GLPG0187
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM. GLPG0187 inhibits migrasome biogenesis without cytotoxicity.
Integrin  
Cancer  
19
HY-P1860A TNF-α (31-45), human TFA
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.
TNF Receptor   NF-κB   Apoptosis  
Inflammation or Immune System Disease  
13
HY-P1860 TNF-α (31-45), human
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.
TNF Receptor   NF-κB   Apoptosis  
Inflammation or Immune System Disease  
13
HY-N0250 Saikosaponin D
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
STAT   NF-κB   Estrogen Receptor/ERR   Bacterial  
Lung Cancer   Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Obesity  
12
HY-P9915 Daratumumab
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

Species: Human

CD38   ADC Antibodies  
Inflammation or Immune System Disease   Leukemia/Lymphoma/Myeloma  
12
HY-P0278 RGD
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
Integrin  
11
HY-P3160 Fibronectin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans.
This product is a human Fibronectin obtained by recombinant expression in a rice expression system.
Integrin  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
11
HY-13541A ADH-1 trifluoroacetate
ADH-1 trifluoroacetate is an N-cadherin antagonist, which inhibits N-cadherin mediated cell adhesion.
Cadherin  
10
HY-P1740A RGD peptide (GRGDNP) TFA
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation.
Integrin   Apoptosis  
Cancer   Inflammation or Immune System Disease  
10
HY-13541 ADH-1
ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
Cadherin  
10
HY-P1740 RGD peptide (GRGDNP)
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation.
Integrin   Apoptosis   Caspase  
Digestive System Disease   Digestive System Inflammation  
10
HY-P7387 MIF Protein, Human
MIF Protein, Human has assumed an important role as a pivotal regulator of innate immunity. MIF Protein, Human promotes the pro-inflammatory functions of immune cells.

Species: Human; Source: E. coli

Cytokines and Growth Factors

10
HY-15526 PSI-697
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM.
P-selectin  
Cancer  
9
HY-P5321 bFGF (119-126)
bFGF (119-126) is a ligand of bFGF. The complex formed by bFGF (119-126) and bFGF can bind to FGFR1, while inhibiting the bFGF-FGFR1 interaction, FGFR1 phosphorylation and downstream signaling pathways. Therefore, bFGF (119-126) induces cell apoptosis and inhibits cell proliferation, migration, angiogenesis and metastasis. When conjugated with a carrier, bFGF (119-126) enhances cellular uptake via FGFR-mediated endocytosis and serves as an effective FGFR-targeted ligand. When used in combination with ultrasound and Doxorubicin (HY-15142A), bFGF (119-126) significantly enhances the inhibitory effect on tumors. bFGF (119-126) is applicable to research related to lung cancer, breast cancer, glioblastoma and ovarian cancer.
FGFR  
Lung Cancer   Breast Cancer   Ovarian Cancer  
6
HY-14571 E7820
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML).
Molecular Glues   Integrin  
Cancer   SARS-CoV-2 Infection   Obesity  
5
HY-N2098 Obtusifolin
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.
NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
4
HY-P1408 Obtustatin
Obtustatin is a non-RGD disintegrin consisting of 41 residues. Obtustatin inhibits the adhesion of α1β1 integrin to type IV Collagen (HY-NP003), blocks α1β1 integrin signaling in endothelial cells, and suppresses FGF2-induced angiogenesis. Obtustatin inhibits tumor progression in mouse models and upregulates VEGF expression in sarcoma-bearing mice. Obtustatin can be used in research related to Lewis lung carcinoma and S-180 sarcoma.
Integrin   VEGFR  
Lung Cancer  
4
HY-106139 Bimosiamose
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.
P-selectin   L-Selectin   E-Selectin  
Inflammation or Immune System Disease   SARS-CoV-2 Infection  
4
HY-108831 Natalizumab
Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4+ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses.

Species: Human

Integrin  
Leukemia/Lymphoma/Myeloma   Experimental Autoimmune Encephalomyelitis   Multiple Sclerosis   Experimental Autoimmune Encephalomyelitis  
4
HY-137561 Bexotegrast
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung.
Integrin  
Inflammation or Immune System Disease  
4
HY-149897 HA-CD44 interaction inhibitor 2
HA-CD44 interaction inhibitor 2 is a CD44 inhibitor that can inhibit the interaction between Hyaluronic acid (HA) (HY-B0633A) and CD44. HA-CD44 interaction inhibitor 2 acts as an antiproliferative agent against CD44+ cancer cells. HA-CD44 interaction inhibitor 2 can disrupt the integrity of cancer spheres and reduce cancer cell viability in a dose-dependent manner. HA-CD44 interaction inhibitor 2 is applicable for tumor research.
Transmembrane Glycoprotein   CD44  
Triple-Negative Breast Cancer  
3
HY-P9911 Vedolizumab
Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.

Species: Human

Integrin  
Inflammation or Immune System Disease  
3
HY-P99126 Anti-Mouse/Human CD44 Antibody (IM7)
Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody that recognizes a conserved epitope outside the HA-binding domain of the CD44 molecule. Anti-Mouse/Human CD44 Antibody (IM7) exerts a potent anti-inflammatory effect by inducing the shedding of cell surface CD44, significantly improving symptoms in mice with rheumatoid arthritis without affecting relevant immune responses. Anti-Mouse/Human CD44 Antibody (IM7) can be used for researches on inflammation conditions and cancer such as arthritis and osteosarcoma.

Species: Human/Mouse

Transmembrane Glycoprotein   CD44  
Cancer   Inflammation or Immune System Disease   Arthritis  
3
HY-108910 Chymotrypsin
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration.
Toll-like Receptor (TLR)   NF-κB   MMP  
Breast Cancer   Digestive System Inflammation   Gastric Disease   Metastatic Melanoma   Pharyngitis   Rheumatoid Arthritis  
3
HY-P7388 MIF Protein, Mouse
MIF Protein, Mouse has assumed an important role as a pivotal regulator of innate immunity.MIF Protein, Mouse promotes the pro-inflammatory functions of immune cells.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors

3
HY-P80447 CD31 Antibody (YA541)
CD31 Antibody (YA541) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD31.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

3
HY-P2284 AD 01
AD 01, a 24 amino acid peptide of FKBPL (FK506-binding protein like), possesses potent anti-angiogenic activity. AD 01 bind to the CD44 receptor and inhibit tumour cell migration in a CD44 dependant manner.
Transmembrane Glycoprotein  
Cancer  
2
HY-113439S 12-HETE-d8
12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway.12-HETE has both anti-thrombotic and pro-thrombotic effects. 12-HETE is a neuromodulator.
Apoptosis  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
2
HY-N1966 (E)-Osmundacetone
(E)-Osmundacetone is an inhibitor of the MAPK pathway. (E)-Osmundacetone inhibits the activation of the MAPK signaling pathway and restores the expression of PPARα/ACOX1. (E)-Osmundacetone abrogates abnormal cell proliferation, migration and liver metastasis induced by PTPRO silencing in colorectal cancer cells. (E)-Osmundacetone blocks OA-RD17-mediated activation of the MAPK signaling pathway, thereby reducing macrophage proliferation and migration. (E)-Osmundacetone is applicable to relevant research on colorectal cancer.

Source: Inonotus hispidus

p38 MAPK   PPAR  
Colorectal Cancer  
2
HY-P990859 Anti-CD44 Antibody (Hermes-1)
Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derived Growth Factor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic.

Species: Human

Transmembrane Glycoprotein  
Cancer  
2
HY-103358 KF38789
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.
P-selectin  
Inflammation or Immune System Disease  
2
HY-P9984 Etrolizumab
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD).

Species: Human

Integrin  
Cancer  
2
HY-P2230 Angstrom6
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.
PAI-1  
Cancer  
2
HY-P99051 Tinurilimab
Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system.

Species: Human

Transmembrane Glycoprotein  
Cancer   Inflammation or Immune System Disease  
2
HY-P2300 Cyclo(Arg-Gly-Asp-D-Phe-Cys)
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors.
Integrin  
2
HY-P7467 AGER Protein, Human (HEK293, His)
AGER Protein, Human (HEK293, His) is human recombinant AGER with a His tag at the C-terminus. AGER Protein, Human (HEK293, His) is expressed by mammalian expression system and the target gene encoding Ala23-Ala344 is expressed.

Species: Human; Source: HEK293

Receptor Proteins

2
HY-P70832 HABP2 Protein, Human (HEK293, His)
HABP2 is a protein that cleaves the alpha chain of fibrinogen as well as the beta chain between "Lys-53" and "Lys-54" at multiple sites, preventing direct formation of a fibrin clot. It activates coagulation factor VII and converts prourokinase into its active form. HABP2 Protein, Human (HEK293, His) is the recombinant human-derived HABP2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Hydrolases (EC 3)

2
HY-P86463 CD44 Antibody (YA6155)
CD44 Antibody (YA6155) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD44.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

2
HY-NP163 Wheat germ agglutinin-AF350
Wheat germ agglutinin-AF350 (WGA-AF350) is a plant lectin that contains the fluorescent dye AF350, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF350 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA.
Fluorescent Dye  
Cancer  
1
HY-10201S4 Sorafenib-d3 tosylate
Sorafenib-d3 (Donafenib) tosylate is the deuterated-labeled Sorafenib tosylate (HY-10201A). Sorafenib (Bay 43-9006) tosylate is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib tosylate induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib tosylate inhibits tumor growth and metastasis in mouse and rat models. Sorafenib tosylate can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
Isotope-Labeled Compounds   Raf   VEGFR   FLT3   Autophagy   Apoptosis   STAT   Akt   MMP   Cadherin   p38 MAPK   ERK   MEK   PI3K   PARP   Bcl-2 Family  
Neurological, Eye or Ear Disease   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Digestive System Inflammation   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
1
HY-E70182 Hyaluronidase 2
Hyaluronidase 2 (EC:3.2.1.35; HYAL2) is a hyaluronidase. Hyaluronidase 2 cleaves high-molecular-weight hyaluronan into intermediate, ~20 kDa, and tetrasaccharide fragments. Hyaluronidase 2 directly interacts with CD44 and ERM proteins, reduces CD44 hyaluronan binding capacity and ERM activation. Hyaluronidase 2 can be used for the research of gliomas, inflammatory bowel disease, congenital heart defects, heart failure.
CD44  
Glioma   Inflammatory Bowel Disease   Heart Failure  
1
HY-P9987A Crizanlizumab (anti-P-selectin)
Crizanlizumab (anti-P-selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease.
P-selectin  
Inflammation or Immune System Disease  
1
HY-N0620 Mulberroside C
Mulberroside C is one of the main bioactive components in white mulberry (Morus alba L.). Mulberroside C exhibits antiplatelet, antiviral and neutrophil-regulating activities, and binds to EV-A71 VP1 with a Kd value of 1.289 nM. Mulberroside C reduces the phosphorylation level of ERK, promotes the phosphorylation of IP3RI at the Ser1756 site, and decreases calcium influx and calcium mobilization. Mulberroside C inhibits the expression of P-selectin (P-selectin). Mulberroside C upregulates the cyclic nucleotide signaling pathway in human platelets. Mulberroside C binds to IL-23R, upregulates the expression of G-CSF, GM-CSF and RASGRP1, and activates the RAS/ERK signaling pathway. Mulberroside C promotes neutrophil maturation, accelerates the recovery of leukopenia, and enhances the antibacterial activity of neutrophils. Mulberroside C inhibits the replication of hepatitis C virus in replicon cells. Mulberroside C prevents the uncoating and genome release of EV-A71, and inhibits the synthesis of viral proteins and RNA. Mulberroside C can be used in studies related to thrombosis-mediated cardiovascular diseases, chemotherapy- and radiotherapy-induced leukopenia, hepatitis C virus infection, and hand, foot and mouth disease.
HCV   Enterovirus   PERK   Calcium Channel   P-selectin   HCN Channel   Ras   ERK   DNA/RNA Synthesis  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Hepatitis C Virus Infection   Staphylococcus Aureus Infection  
1
HY-N1480R (-)-Fucose (Standard)
(-)-Fucose (Standard) is the analytical standard of (-)-Fucose. This product is intended for research and analytical applications. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth.
Reference Standards   Endogenous Metabolite   Parasite  
Cancer   Infection   Metabolic or Endocrine Disease  
1
HY-129099 N-Desmethyltamoxifen
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
PKC   Estrogen Receptor/ERR   Drug Metabolite  
Cancer  
1
HY-P990247 Anti-Mouse E-selectin/CD62E Antibody (9A9)
Anti-Mouse E-selectin/CD62E Antibody (9A9) is an anti-mouse E-selectin/CD62E IgG2b monoclonal antibody. Anti-Mouse E-selectin/CD62E Antibody (9A9) has an inhibitory effect on cancer cell colonization. Anti-Mouse E-selectin/CD62E Antibody (9A9) can be used for researches on inflammation conditions and cancer such as acute microvascular inflammation and breast cancer.

Species: Mouse

E-Selectin  
Cancer   Inflammation or Immune System Disease  
1
HY-10201S2 Sorafenib-13C,d3
Sorafenib-13C,d3 (Bay 43-9006-13C,d3) is the 13C, deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
Isotope-Labeled Compounds   Raf   VEGFR   FLT3   Autophagy   Apoptosis   STAT   Akt   MMP   Cadherin   p38 MAPK   ERK   MEK   PI3K   PARP   Bcl-2 Family  
Gastric Cancer   Liver Cancer   Ovarian Cancer   Digestive System Inflammation   Small Cell Lung Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   Metastatic Colorectal Cancer   Metastatic Prostate Cancer   Multiple Myeloma   Metastatic Pancreatic Cancer   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Obesity   Lung Fibrosis  
1
HY-P99891 Rovelizumab
Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke.

Species: Human

Integrin  
Blood or Cardio-cerebrovascular Disease  
1
HY-E70157 Fucosyltransferase 8
Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans.
Glucosylceramide Synthase (GCS)  
Infection  
1
HY-P99411 Ontamalimab
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease.

Species: Human

Integrin  
Inflammation or Immune System Disease  
1
HY-P99263 Inclacumab
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion.

Species: Human

P-selectin  
Blood or Cardio-cerebrovascular Disease  
1
HY-P2975 Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)
Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural element in animal tissues, forming part of the scaffolding that supports tissue architecture. It interacts with type IV collagen through entactin and perlecan, connects to cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins, and contains functional domains that facilitate collagen binding, cell adhesion, heparin interaction, and promote neurite outgrowth.
Endogenous Metabolite   Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
1
HY-113230B Galactosylhydroxylysine hydrochloride
Galactosylhydroxylysine hydrochloride is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine hydrochloride is released during bone resorption and has been shown to be elevated in metabolic bone loss.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-N0554 Escin IA
Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions.
HIV Protease   Monoamine Oxidase  
Cancer   Infection   Gastric Disease  
1
HY-N7694 Isotoosendanin
Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation.
TGF-β Receptor   JAK   STAT   Apoptosis  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-N2456 Mogroside IV-E
Mogroside IV-E is a PUS1 inhibitor that reduces PUS1 expression and inhibits bone metastasis of prostate cancer. Mogroside IV-E can be used in prostate cancer-related research.
DNA/RNA Synthesis  
Prostate Cancer  
1
HY-W020790 Sialyl-Lewis X
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin). Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation.
Endogenous Metabolite  
Inflammation or Immune System Disease  
1
HY-N2013 Aristolactam I
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.
Drug Metabolite   Aquaporin   Cadherin   TGF-beta/Smad  
Metabolic or Endocrine Disease   Breast Cancer   Liver Cancer  
1
HY-129099A N-Desmethyltamoxifen hydrochloride
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
PKC   Estrogen Receptor/ERR   Drug Metabolite  
Digestive System Disease   Breast Cancer   Ovarian Cancer   Digestive System Inflammation  
1
HY-B0579S Cyclosporin A-d4
Cyclosporin A-d4 (Cyclosporine A-d4) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.
Isotope-Labeled Compounds   Molecular Glues   Complement System   Antibiotic   Cyclophilin  
Neurological, Eye or Ear Disease   Breast Cancer   Prostate Cancer   Viral Infection   Autoimmune Disease   SARS-CoV-2 Infection   Lung Fibrosis  
1
HY-P9987 Crizanlizumab
Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease.

Species: Human

P-selectin  
Blood or Cardio-cerebrovascular Disease  
1
HY-P3448 Certepetide
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
Integrin   Complement System  
1
HY-NP132A Recombinant humanized type III collagen (MW 55900)
Recombinant humanized type III collagen (MW 55900) is a type III collagen with a molecular weight of 55900 Da. Recombinant humanized type III collagen has various biological functions, such as promoting skin extracellular matrix regeneration and improving the cell microenvironment. Recombinant humanized type III collagen inhibits the proliferation, migration, and invasion of breast cancer cells. Type III collagen functions in cell adhesion, migration, proliferation and differentiation through its interaction with integrins.
Biochemical Assay Reagents   Integrin   Autophagy   Apoptosis   Discoidin Domain Receptor  
Breast Cancer  
1
HY-P9947 Efalizumab
Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research.

Species: Human

Integrin  
Infection  
1
HY-N1347 Robinetin
Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation.
Fungal   HIV Integrase   Bacterial  
Infection  
1
HY-P5133 Synstatin (92-119)
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R with anti-angiogenic, anti-proliferative, antioxidant and anti-tumor activities. Synstatin (92-119) competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupts the formation of the syndecan-1 : integrin : IGF1R ternary complex, inhibits integrin activation and talin-mediated signaling pathways, and blocks VEGF-induced angiogenesis. Synstatin (92-119) is applicable to research related to cancer and hepatocellular carcinoma.
Integrin  
Cancer  
1
HY-W008859 Tetrac
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.
Integrin   Endogenous Metabolite  
Cancer  
1
HY-126437B Poly-L-lysine hydrobromide (MW 70000-150000)
Poly-L-lysine (hydrobromide) (MW 70000-150000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine (hydrobromide) (MW 70000-150000) has good biocompatibility. Poly-L-lysine (hydrobromide) (MW 70000-150000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface.
Biochemical Assay Reagents  
1
HY-W591424 m-PEG2000-NHS ester
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions.
Biochemical Assay Reagents   MMP  
Colorectal Cancer  
1
HY-N2124 Parishin B
Parishin B is a multi-target biological agent with anti-epileptic, anti-fascioliasis and anti-breast cancer lung metastasis activities. Parishin B regulates the gene/protein activities of ACLY, unc13c, γ-aminobutynergic system, pro-inflammatory system, antioxidant system, monoaminergic system, ferroptosis-related pathways, as well as GST, CatL, Trx and TRIB3. Parishin B modulates energy-lipid metabolism, synaptic function, neurotransmitter balance, neuroinflammation, oxidative stress, parasite detoxification/invasion processes, as well as apoptosis, cell cycle, proliferation and metastasis of cancer cells. Parishin B can be used for related research of epilepsy, fascioliasis and breast cancer lung metastasis
Reactive Oxygen Species (ROS)   Ferroptosis   Apoptosis  
Lung Cancer   Breast Cancer   Parasitic Infection   Epilepsy   Antioxidant Agent  
1
HY-N0162R Luteolin (Standard)
Luteolin (Standard) is the analytical standard of Luteolin. This product is intended for research and analytical applications. Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells.
Reference Standards   Keap1-Nrf2   Apoptosis   Autophagy   Endogenous Metabolite  
Inflammation or Immune System Disease   Lung Cancer  
1
HY-145934A UDP-GlcNAz disodium
UDP-GlcNAz disodium is the analogue of UDP-GlcNAc disodium (HY-112174). UDP-GlcNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GlcNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GlcNAc disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
OGT   Biochemical Assay Reagents   Glycosidase  
Metabolic or Endocrine Disease  
1
HY-W009783 1-Deoxymannojirimycin hydrochloride
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. 1-Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . 1-Deoxymannojirimycin hydrochloride increases high mannose structures. 1-Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer.
HIV   Influenza Virus  
Colorectal Cancer   Liver Cancer   Viral Infection  
1
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis.
Endothelin Receptor   Integrin  
Neurological, Eye or Ear Disease  
1
HY-10201S Sorafenib-d3
Sorafenib-d3 (Donafenib) is the deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
Isotope-Labeled Compounds   Raf   VEGFR   FLT3   Autophagy   Apoptosis   STAT   Akt   MMP   Cadherin   p38 MAPK   ERK   MEK   PI3K   PARP   Bcl-2 Family  
Gastric Cancer   Liver Cancer   Ovarian Cancer   Digestive System Inflammation   Small Cell Lung Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   Metastatic Colorectal Cancer   Metastatic Prostate Cancer   Multiple Myeloma   Metastatic Pancreatic Cancer   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Obesity   Lung Fibrosis  
1
HY-154812 Gintemetostat
Gintemetostat (KTX-1001) is an orally active, highly specific NSD2/MMSET histone methyltransferase inhibitor with human NSD2 IC50 values ranging 0.460-2.17 nM and NSD2 SET domain IC50 of 2.32 nM and Kd values ranging 6.3-70.4 nM.Gintemetostat reduces H3K36me2 levels, impairs multiple myeloma cell adhesion and colony formation, enhances cytotoxicity, boosts T-cell activation, and sensitizes resistant multiple myeloma cells to other agents.Gintemetostat can be used for the research of multiple myeloma and relapsed and refractory multiple myeloma.
Histone Methyltransferase   CD44  
Multiple Myeloma  
1
HY-P3161 Lactoferrin from Bovine milk
Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities.
HSV  
Inflammation or Immune System Disease  
1
HY-P70507 CD44 Protein, Human (HEK293, His)
CD44 Protein is a type of cell surface receptor protein. CD44 Protein mediates various signaling pathways, including protein kinases, changes in the cytoskeleton, intracellular pathways, proteases, and transcription factors, which promote cancer cell division, proliferation, invasion, angiogenesis, and metabolic changes. The expression level of CD44 Protein is positively correlated with the malignancy and invasiveness of glioblastoma. CD44 Protein, Human (HEK293, His) is a recombinant CD44 protein tagged with a C-6*His label, expressed by HEK293. CD44 Protein, Human (HEK293, His) consists of 200 amino acids and has a molecular weight of 38-50 kDa.

Species: Human; Source: HEK293

CD Antigens B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

1
HY-P72892 CD31/PECAM-1 Protein, Human (HEK293)
CD31/PECAM-1 Protein, a pivotal cell adhesion molecule, is essential for leukocyte transendothelial migration (TEM) in most inflammatory conditions. PECAM1 modulates bradykinin receptor BDKRB2 activation and regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Signaling through PECAM-1 leads to the activation of neutrophils, monocytes and leukocytes. CD31/PECAM-1 Protein, Human (HEK293) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with tag free.

Species: Human; Source: HEK293

CD Antigens Macrophage CD Proteins CD31/PECAM-1

1
HY-P75347 CHL1 Protein, Human (HEK293, His)
CHL1 Protein, Human (HEK293, His) is the recombinant human-derived CHL1 protein, expressed by HEK293, with C-His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs) Immunoglobulin-like Cell Adhesion Molecules Neural Cell Adhesion Molecule L1-Like Protein (CHL1)

1
HY-P76185 HABP1/C1QBP Protein, Mouse (His)
The HABP1/C1QBP proteins are part of the MAM33 family, related to a unique family of proteins known for unique characteristics and functions. Among the MAM33 family, HABP1 may play an important role in related cellular processes, but its specific function still needs to be explored. HABP1/C1QBP Protein, Mouse (His) is the recombinant mouse-derived HABP1/C1QBP protein, expressed by E. coli , with N-His labeled tag.

Species: Mouse; Source: E. coli

Complement System Complement Regulatory Proteins HABP1/C1QBP

1
HY-P72490 CD31/PECAM-1 Protein, Human (HEK293, His)
CD31/PECAM-1 Protein is a cell-cell adhesion protein that is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. CD31/PECAM-1 Protein, Human (HEK293, His) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

CD Antigens Macrophage CD Proteins CD31/PECAM-1

1
HY-P81087 AGEs Antibody
AGEs Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to AGEs.

Host: Rabbit; Reactivity: Human, Mouse, Rat,

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

1
HY-P82167 MIF Antibody (YA1912)
MIF Antibody (YA1912) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MIF.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

1
HY-KE7057 O-Glycosidase

O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.

Molecular Biology Restriction Endonuclease

1
HY-10201S1 Sorafenib-d4
Sorafenib-d4 (Bay 43-9006-d4) is the deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
Isotope-Labeled Compounds   Raf   VEGFR   FLT3   Autophagy   Apoptosis   STAT   Akt   MMP   Cadherin   p38 MAPK   ERK   MEK   PI3K   PARP   Bcl-2 Family  
Gastric Cancer   Liver Cancer   Ovarian Cancer   Digestive System Inflammation   Small Cell Lung Cancer   Non-Small Cell Lung Cancer   Metastatic Breast Cancer   Metastatic Colorectal Cancer   Metastatic Prostate Cancer   Multiple Myeloma   Metastatic Pancreatic Cancer   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Obesity   Lung Fibrosis  
/
HY-N7603 Rubrofusarin triglucoside
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM.
Monoamine Oxidase  
Neurological, Eye or Ear Disease  
/
HY-P4027 HCV-1 e2 Protein (554-569)
HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2.
HCV  
Infection  
/
HY-P991254 VPI-2690B
VPI-2690B is a human monoclonal antibody (mAb) targeting Integrin aVb3. VPI-2690B inhibits TGF-β signaling. VPI-2690B can be used in Diabetic nephropathies research.

Species: Human

Integrin   TGF-β Receptor  
Metabolic or Endocrine Disease  
/
HY-P5351 Hyaluronan-binding peptide, biotin labeled
Hyaluronan-binding peptide, biotin labeled is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.)
Others  
Cancer  
/
HY-P990248 Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) is an anti-mouse E-Cadherin/CD324 IgG1 monoclonal antibody. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can downregulate the HER signaling axis and PI3K/Akt/mTOR signaling pathway. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can inhibit the proliferation of tumor cells and induce their apoptosis. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can be used for researches on cancer and inflammation conditions such as breast cancer, chronic compression injury (CCI) and asthma.

Species: Mouse

Cadherin   EGFR   PERK   Akt   mTOR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Breast Cancer  
/
HY-P991328 MAb604.107
MAb604.107 is a human monoclonal antibody (mAb) targeting NOTCH1. MAb604.107 inhibits the proliferation and CD34/CD44 expression of primary T-ALL cells. MAb604.107 has anti-tumor activity in four tumor xenograft mouse models: MDA-MB-231, HCC-1806, BT-474, and HCT-116. MAb604.107 can be used in T acute lymphoblastic leukemia research.

Species: Human

Notch  
Cancer  
/
HY-N17650 Salviamarinic acid A
Salviamarinic acid A is a water-soluble phenolic acid that can be extracted from Salvia miltiorrhiza with potent anti-pulmonary fibrosis activity. Salviamarinic acid A significantly increases cell viability, cell index, cell motility and E-cadherin expression, and reduces TGF-β1, α-SMA and Collagen I levels. Salviamarinic acid A can be used for pulmonary fibrosis research.
TGF-β Receptor   Collagen   Cadherin  
Respiratory Disease  
/
HY-P992436 PAS-003
PAS-003 is a humanized monoclonal antibody targerting α5β1 integrin. PAS-003 modulates immune cell migration, immune cell adhesion, improves behavior, and improves survival in ALS mouse models. PAS-003 can be used for the research of amyotrophic lateral sclerosis.

Species: Human

Integrin  
Amyotrophic Lateral Sclerosis  
/
HY-B0094S3 Artemisinin-13C,d4
Artemisinin-13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.
Ferroptosis   HCV   Parasite   Akt   Isotope-Labeled Compounds  
Infection   Neurological, Eye or Ear Disease  
/
HY-P992392 JM1-24-3
JM1-24-3 is an anti-MUC18 mouse monoclonal antibody with a Kd value of 1.60e-9 M. JM1-24-3 reduces the phosphorylation levels of p-AKT (Ser473) and p-mTOR (Ser2448) in a time-dependent manner. JM1-24-3 exhibits anticancer activity against melanoma. JM1-24-3 can be used in studies related to metastatic melanoma.

Species: Human

Transmembrane Glycoprotein   Akt   mTOR  
Metastatic Melanoma  
/
HY-P11052 A8 peptide
A8 peptide is a Hsp72 antagonist. A8 peptide inhibits tumor progression and metastasis as well as enhances the cancer cells' sensitivity to apoptosis induced by chemotherapeutic agents (such as Cisplatin (HY-17394)) by blocking the Hsp72-TLR2 interaction and the subsequent activation of MDSCs. A8 peptide can be used for cancers research.
HSP  
/
HY-158528 A3 glycan
A3 glycan (A3 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-N1480S2 (-)-Fucose-13C-2
(-)-Fucose-13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
Isotope-Labeled Compounds   Endogenous Metabolite   Parasite  
Infection   Metabolic or Endocrine Disease  
/
HY-P992437 PF-03475952
PF-03475952 is a fully human IgG2 monoclonal antibody targeting CD44. PF-03475952 binds an epitope in CD44’s constant exons, blocks CD44-hyaluronic acid interaction, reduces cell surface CD44, and does not cross-react with rodent CD44 or LYVE-1. PF-03475952 induces cancer cell apoptosis, inhibits LPS (HY-D1056)-induced leukocyte cytokine release and cancer metastasis, and reduces CD44 expression on circulating CD3+ lymphocytes in cynomolgus monkeys. PF-03475952 can be used for the research of rheumatoid arthritis and hepatocellular carcinoma.

Species: Human

CD44   Apoptosis  
Liver Cancer   Rheumatoid Arthritis  
/
HY-P10403 IGFBP-3 peptide
IGFBP-3 peptide is a 18-amino acid insulin-like growth factor binding protein-3. IGFBP-3 peptide binds Humanin (HY-P1928) and Hyaluronan (HY-B0633A), blocks the interaction of CD44 and hyaluronan.
IGF-1R  
Cancer   Inflammation or Immune System Disease  
/
HY-D2836I FITC-HA (MW 5000)
FITC-HA (MW 5000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-N1127S Tricin-d6
Tricin-d6 is the deuterium labeled Tricin. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.
CMV  
Cancer   Cytomegalovirus Infection  
/
HY-NP216 PA-IIL
PA-IIL (LecB) is a lectin produced by Pseudomonas aeruginosa. PA-IIL binds to glycosylated β1-integrin, fucose-containing glycosphingolipids, fucosylated/mannosylated neutrophil glycoconjugates, and pre-formed neutrophil extracellular traps. PA-IIL disrupts host defenses: it creates favorable conditions for Pseudomonas aeruginosa infection and dissemination by modulating the bactericidal activity of neutrophils, impairing the trafficking and recruitment of immune cells, and compromising the repair capacity of epithelial barriers. PA-IIL can be used in studies related to Pseudomonas aeruginosa infection.
Integrin   Endogenous Metabolite   Bacterial  
Pseudomonas Aeruginosa Infection  
/
HY-158472 Sialylated Core 1 O-glycan (C1S(3)1)
Sialylated Core 1 O-glycan (C1S(3)1) () is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-P990455 Anti-Integrin a11/ITAG11 Antibody
The Anti-Integrin a11/ITAG11 Antibody is a CHO-expressed human antibody targeting Integrin a11/ITAG11. The Anti-Integrin a11/ITAG11 Antibody is composed of huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-Integrin a11/ITAG11 Antibody can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).

Species: Human

Others  
Inflammation or Immune System Disease  
/
HY-158452 A3G3 glycan (G3)
A3G3 glycan (G3) (A3G3 N-linked oligosaccharide; A3G(4)3 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-N21980 5α-Epoxyalantolactone
5α-Epoxyalantolactone is an orally active, blood-brain barrier-permeable ANXA2 inhibitor. 5α-Epoxyalantolactone binds to ANXA2, blocks the formation of ANXA2-S100A10 heterotetramers, inhibits the membrane trafficking of E-cadherin, and prevents metastasis of breast cancer cells as well as proliferation of breast cancer stem cells. 5α-Epoxyalantolactone improves cognitive and memory impairments by inhibiting the iNOS/COX-2/NF-κB pathway and reducing the activity of cerebral AChE. 5α-Epoxyalantolactone can be used in studies related to Alzheimer's disease and triple-negative breast cancer.
Annexin A   NO Synthase   COX   NF-κB   Cholinesterase (ChE)  
Triple-Negative Breast Cancer   Alzheimer's Disease  
/
HY-158458 A2[3]G1F1(α-1-3) glycan
A2[3]G1F1(α-1-3) glycan (A2[3]G1F1(a1-3) glycan) is an asymmetric Lewis X polysaccharide and N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions.
Biochemical Assay Reagents  
/
HY-158466 Human IgG Glycoprotein
Human IgG Glycoprotein is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-D2836K FITC-HA (MW 4000000)
FITC-HA (MW 4000000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-139201C Poly-D-lysine hydrobromide (MW 1000-5000)
Poly-D-lysine hydrobromide (MW 1000-5000) (PDLHB (MW 1000-5000)) is a synthetic cationic polypeptide polymer commonly used as a cell adhesion promoter and surface coating molecule. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide.
CaSR  
/
HY-W008859R Tetrac (Standard)
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities.
Reference Standards   Integrin   Endogenous Metabolite  
Cancer  
/
HY-158459 A2G2F2 glycan
A2G2F2 glycan (A2G2F2(a1-3) glycan) is a Lewis X polysaccharide containing two Lewis X epitopes and is a symmetric N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions.
E-Selectin   Biochemical Assay Reagents  
/
HY-E70140 α-1,4-N-Acetylglucosaminyltransferase 4
α-1,4-N-Acetylglucosaminyltransferase 4 (EC 2.4.1, A4GNT) catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans and suppresses H. pylori growth.
Bacterial  
Infection  
/
HY-158448 FA2G2 glycan (G2F)
FA2G2 glycan (G2F) (FA2G2 N-linked oligosaccharide; F(6)A2G2) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-187267S [U-15N]-TNF-α
[U-15N]-TNF-α is the 15N-labeled TNF-α. Overexpression of TNF-α triggers chronic inflammation (linked to autoimmune diseases) and contributes to tumor invasion and metastasis, acting as a key molecule connecting inflammation and cancer. This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis.
Isotope-Labeled Compounds  
Cancer   Inflammation or Immune System Disease  
/
HY-158467 Core 1 O-glycan (C1), 2AB labelled
Core 1 O-glycan (C1), 2AB labeled is a 2AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-D2062 ATTO 740 NHS ester
ATTO 740 NHS ester is a near-infrared fluorescent dye and a multimodal fluorescence/photoacoustic contrast agent with excellent near-infrared emission properties and extremely high photostability. The photoacoustic signal of ATTO 740 NHS ester shows no significant decrease after continuous irradiation with a 750 nm laser for 30 min, making it suitable for in vivo fluorescence imaging and photoacoustic contrast imaging. When conjugated with the cystine knot peptide R01, ATTO 740 NHS ester enables precise detection of integrin αvβ6-positive cells and tumors in nude mouse xenograft models.
Fluorescent Dye   Integrin  
Cancer  
/
HY-181781 LSD1-IN-48
LSD1-IN-48 is a tranylcypromine-pyrimidine derivative and selective LSD1 inhibitor with a human IC50 of 7.87 nM. LSD1-IN-48 increases H3K4me1/2 histone methylation levels. LSD1-IN-48 induces apoptosis, upregulates CD86, downregulates SOX2 and CD44, inhibits proliferation in cancer cells. LSD1-IN-48 can be used for the research of acute myeloid leukemia.
Histone Demethylase   CD44   Apoptosis  
Acute Myeloid Leukemia  
/
HY-158468 Sialylated Core 1 O-glycan (C1S(3)1), 2AB labelled
Sialylated Core 1 O-glycan (C1S(3)1), 2AB labelled () is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-P4027A HCV-1 e2 Protein (554-569) TFA
HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2.
HCV  
Infection  
/
HY-P11018 (123B9)2-L2-PTX
(123B9)2-L2-PTX is an EphA2-agonistic peptide-drug conjugate (PDC). (123B9)2-L2-PTX consists of a dimeric 123B9 (HY-P10579) and Paclitaxel (HY-B0015). (123B9)2-L2-PTX significantly reduces circulating tumor cells and inhibits lung tumor metastasis in breast-cancer-Metastasis mice model. (123B9)2-L2-PTX can be used for cancers research, such as melanomas and ovarian and breast cancers.
Peptide-Drug Conjugates (PDCs)   Ephrin Receptor  
Cancer  
/
HY-P10988 LVTX-8
LVTX-8 is a peptide toxin, exacted from Lycosa vittata. LVTX-8 has potent anticancer and and anti-metastasis activities towards lung cancer with strong cytotoxicity. LVTX-8 significantly induces apoptosis and inhibits the proliferation, invasion and migration of lung cancer cells through P53 hypoxia pathways and integrin signaling. LVTX-8 significantly inhibits the tumor growth and metastasis in A549/H460 xenograft mice model.
Apoptosis   MDM-2/p53   Integrin  
/
HY-136699 Excisanin A
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer.
MMP   Integrin   Src   FAK  
Cancer  
/
HY-P990871 Anti-CD11a/LFA-1α Antibody (R7-1)
Anti-CD11a/LFA-1α Antibody (R7-1) is a kind of mouse IgG1 chimeric antibody inhibitor, targeting to human CD11a/LFA-1α. Anti-CD11a/LFA-1α Antibody (R7-1) can neutralize LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. Anti-CD11a/LFA-1α Antibody (R7-1) can be used for the research of inflammation.

Species: Human

Integrin  
Inflammation or Immune System Disease  
/
HY-P992209 Anti-CD318/CDCP1 Antibody (25A11)
Anti-CD318/CDCP1 Antibody (25A11) is an anti-CDCP1 antibody. Anti-CD318/CDCP1 Antibody (25A11) drives the internalization of antibody-CDCP1 complexes, inhibits cancer cell migration and invasion, and blocks downstream migration/invasion signaling pathways. When conjugated with saponin, Anti-CD318/CDCP1 Antibody (25A11) mediates the killing of prostate cancer cells. When conjugated with saponin, this antibody acts as an immunotoxin to inhibit the growth and metastasis of primary prostate tumors in mouse xenograft models. Anti-CD318/CDCP1 Antibody (25A11) is applicable to prostate cancer-related research.

Species: Human

Transmembrane Glycoprotein  
Prostate Cancer  
/
HY-P3118 Bz-IEGR-pNA acetate
Bz-IEGR-pNA acetate is a trypsin substrate that can be hydrolyzed by prostate kinase release enzyme-related peptide KLKs.
Biochemical Assay Reagents  
/
HY-P11798 P-Selectin binding peptide
P‑Selectin binding peptide is a short peptide that specifically targets P‑selectin. P‑Selectin binding peptide binds with high affinity to P‑selectin, which is highly expressed on activated platelets, inflamed endothelium, and in the tumor microenvironment. P‑Selectin binding peptide is used for precise targeted delivery and intervention in inflammation, thrombosis, and tumors.
P-selectin  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-N16010 4-HNE-Dimethylacetal
4-HNE-Dimethylacetal is an α,β-unsaturated hydroxyalkenal that can be produced by lipid peroxidation in cells. 4-HNE-Dimethylacetal can be studied in research on cell signal transduction including pathways from cell cycle events to cellular adhesion.
Biochemical Assay Reagents  
/
HY-106428 Icrocaptide
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca2+-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders.
P-selectin  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P11019 IS4
IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases.
CXCR   Calcium Channel  
Cancer  
/
HY-D2836B FITC-HA (MW 200000)
FITC-HA (MW 200000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-158464 Fetuin glycoprotein
Fetuin glycoprotein is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-P992212 Anti-CD62L Antibody (DREG-200)
Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).

Species: Human

L-Selectin  
Ischemia-Reperfusion Injury  
/
HY-P991794 Anti-Rat L-selectin Antibody (OX-85)
Anti-Rat L-selectin Antibody (OX-85) reacts with rat L-selectin (CD62L). Anti-Rat L-selectin Antibody (OX-85) inhibits L-selectin in vivo and in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Rat

L-Selectin  
Cancer   Inflammation or Immune System Disease  
/
HY-P3627 Nagrestipen
Nagrestipen, a human macrophage inflammatory protein-1 alpha (MIP-1α) variant, also known as ECI 301. Nagrestipen has antitumor activity and can be used in therapeutic trials to study cancer, tumors, metastases, radiation oncology, and tumor metastasis.
Drug Derivative  
/
HY-N1480S3 (-)-Fucose-13C-3
(-)-Fucose-13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
Isotope-Labeled Compounds   Endogenous Metabolite   Parasite  
Infection   Metabolic or Endocrine Disease  
/
HY-N16719 Picrasidine J
Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and Snail, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors.
Kallikrein   β-catenin   Cadherin   ERK  
Squamous Cell Carcinoma  
/
HY-D2836E FITC-HA (MW 10000)
FITC-HA (MW 10000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-P992414 MS17-38
MS17-38 is a monoclonal antibody targeting PODXL-v2. MS17-38 binds to a specific conformational epitope of PODXL-v2 on gastric cancer cells, modulates target function, inhibits gastric cancer cell growth and migration, and blocks tumor growth and lung metastasis. MS17-38 can be used for the research of gastric cancer.

Species: Human

Others  
Gastric Cancer  
/
HY-N0250R Saikosaponin D (Standard)
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
Reference Standards   STAT   NF-κB   Estrogen Receptor/ERR   Bacterial  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-P11288 ANT308
ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 can be used for the studies of acute myeloid leukemia (AML) and uveal melanoma (UVM).
PACAP Receptor   Apoptosis  
/
HY-P4130 MPS-Gαi2
MPS-Gαi2 is a membrane-permeable inhibitory peptide corresponding to the C-terminal sequence of Gαi2 involved in receptor interaction. MPS-Gαi2 blocks Hep I-induced binding of Gαi2 to LRP, thereby inhibiting pertussis toxin-sensitive Gαi2 signaling and focal adhesion disassembly mediated by thrombospondin/Hep I-calreticulin-LRP. MPS-Gαi2 can be used in studies on G protein signaling and cell adhesion regulation.
Others  
Bacterial Infection  
/
HY-P11033 Pep2 Peptide
Pep2 Peptide (also known as scavenger receptor B2) is a peptide ligand for the transmembrane glycoprotein CD36. Pep2 Peptide selectively binds to CD36 over HAS, IgG and CD44. Pep2 Peptide can be studied in research on enhancing delivery of anticancer agent.
Transmembrane Glycoprotein  
Cancer  
/
HY-P991652 MINT1526A
MINT1526A (RG-7594) is a humanized IgG1 monoclonal antibody inhibitor targeting α5β1 integrin. MINT1526A has significant anti-angiogenic activity. MINT1526A can be used for cancers research.

Species: Human

Integrin  
Cancer  
/
HY-N14915 Adxanthromycin A
Adxanthromycin A, a microbial metabolite, is a ICAM-1/LFA-1 mediated cell adhesion inhibitor.

Source: Streptomyces sp. NA-148

Integrin  
Cancer  
/
HY-N1480S1 (-)-Fucose-13C-1
(-)-Fucose-13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
Isotope-Labeled Compounds   Endogenous Metabolite   Parasite  
Infection   Metabolic or Endocrine Disease  
/
HY-D2836J FITC-HA (MW 3000)
FITC-HA (MW 3000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-135876 γ-Elemene
γ-Elemene ((-)-γ-Elemene) is a lipid-lowering agent. γ-Elemene increases superoxide dismutase (SOD). γ-Elemene reduces the expression of adhesion molecules (VCAM-1, ICAM-1) in cells damaged by H2O2. γ-Elemene regulates lipid peroxidation. γ-Elemene protects cells from peroxidative damage induced by high fat and H2O2. γ-Elemene decreases lipid content. γ-Elemene can be used in the research of atherosclerosis.
SOD   Integrin  
Atherosclerosis and Inflammation  
/
HY-158471 Core 1 O-glycan (C1)
Core 1 O-glycan (C1) is an important O-linked glycan with core structure 1 (MUC1-M). Core 1 O-glycan (C1), 2AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-D2836D FITC-HA (MW 50000)
FITC-HA (MW 50000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-158522 A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labelled
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions.
Biochemical Assay Reagents  
/
HY-D2836C FITC-HA (MW 100000)
FITC-HA (MW 100000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-D3228 IR-820 NHS ester
IR-820 NHS ester is a near-infrared Fluorescent dye. IR-820 NHS ester can be used for the preparation of IR820-E[c (RGDfK)]2.
Fluorescent Dye   Drug Intermediate  
/
HY-P99658A Imaprelimab (powder)
Imaprelimab (powder) is a humanized IgG1κ anti-CD146 antibody. Imaprelimab (powder) exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab (powder) can be used in studies related to brain metastasis of non-small cell lung cancer.

Species: Human

Transmembrane Glycoprotein  
Cerebrovascular Disease   Non-Small Cell Lung Cancer  
/
HY-158442 A2G2 glycan (G2)
A2G2 glycan (G2) (A2G2 N-linked oligosaccharide; A2G(4)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-P10941 VSLRGDTRG
VSLRGDTRG is a synthetic peptide containing the RGD motif from cadherin 17 (CDH17), which binds to α2β1 integrin and activates its signaling pathway. VSLRGDTRG promotes the high-affinity conformational change of β1 integrin through the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. VSLRGDTRG can be used in research on cancers expressing CDH17, such as colon cancer and pancreatic cancer.
Integrin   ERK   FAK  
Inflammation or Immune System Disease  
/
HY-158495 A2 glycan (G0), 2-AA labelled
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions.
Biochemical Assay Reagents  
/
HY-E70142 Glucosaminyl (N-acetyl) Transferase 1
Glucosaminyl (N-acetyl) Transferase 1 ( EC:2.4.1.102, GCNT1) is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch and play an important role in cancer.
Others  
Cancer  
/
HY-W740977 4-Methyl-1-pentanol-d7
4-Methyl-1-pentanol-d7 (Isohexanol-d7) is the deuterium labeled 4-Methyl-1-pentanol (HY-W007511). 4-Methyl-1-pentanol is a volatile aroma component of red wine, which is often used in the production and blending of wine. 4-Methyl-1-pentanol can also be used as an alcohol antagonist to antagonize the effects of ethanol and 1-butanol on cell-cell adhesion, and is used in the study of fetal alcohol syndrome.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-B0094S Artemisinin-d3
Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.
Akt   Parasite   HCV   Ferroptosis  
Infection   Neurological, Eye or Ear Disease  
/
HY-P10770 P-ESBP-DOX
P-ESBP-DOX is a HPMA copolymer-drug conjugate, which is consistituted of the E-selectin binding peptide and the Doxorubicin (HY-15142). P-ESBP-DOX exhibits cytotoxicity against TNFα-activated human vascular endothelial cells IVECs with an IC50 of 0.28 μM. P-ESBP-DOX can be used in research about tumor vasculature.
Peptide-Drug Conjugates (PDCs)   E-Selectin  
Blood or Cardio-cerebrovascular Disease  
/
HY-D2836H FITC-HA (MW 7000)
FITC-HA (MW 7000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-158457 A2[3]G1 N-glycan
A2[3]G1 N-glycan (N/A) is a Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions.
Biochemical Assay Reagents  
/
HY-E70159 Fucosyltransferase 11
Fucosyltransferase 11 (EC:2.4.1.-, FUT11) links alpha-l-fucose onto conalbumin glycopeptides and biantennary N-glycan acceptors. Fucosyltransferase 11 plays an important role in cancer.

Species: Human

Glycosyltransferase  
Cancer  
/
HY-N15267 Ovalitenone
Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42).
FAK   Akt   mTOR  
/
HY-19344S1 Lifitegrast-d6
Lifitegrast-d6 (SAR 1118-d6) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-N14190 Macrosphelide L
Macrosphelide L is a cell adhesion inhibitor. Macrosphelide L inhibits the adhesion of HL-60 cells to HU-VEC cells with an IC50 of 5.6 μM.

Source: Periconia byssoides OUPS-N133

Others  
Cancer  
/
HY-W001288S Indole-4-carboxaldehyde-13C
Indole-4-carboxaldehyde-13C is the 13C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor that regulates glycosylation and inflammation. Indole-4-carboxaldehyde upregulates Glo-1, inhibits MGO-induced NF-κB activation, and suppresses MGO-induced expression of TNF-α and IFN-γ. Indole-4-carboxaldehyde inhibits MGO-induced formation of advanced glycation end products (AGE) and expression of their receptor (RAGE). Indole-4-carboxaldehyde is a core metabolite produced in the pedicels of Summer Black grapes after exogenous gibberellin treatment, and it directly promotes fruit enlargement and fruit set of Summer Black grapes. Indole-4-carboxaldehyde can be used in studies related to hepatic steatosis and plant growth regulation.
Isotope-Labeled Compounds   Glyoxalase (GLO)   NF-κB   TNF Receptor   Drug Intermediate  
Fatty Liver Disease  
/
HY-168943C PLGA nanoparticles, 1μm
PLGA nanoparticles, 1μm, are biodegradable tumor-targeting nanocarriers that can serve as drug delivery enhancers and multidrug resistance inhibitors. PLGA nanoparticles, 1μm, passively enriched through the EPR effect and actively targeted via ligand-mediated endocytosis, can encapsulate various antitumor active molecules. PLGA nanoparticles, 1μm can specifically recognize multiple types of tumor cells and improve cellular uptake, cytotoxicity and antiproliferative effects after modification with ligands such as transferrin, folic acid, and RGD. PLGA nanoparticles, 1μm can encapsulate various therapeutic drugs and can be surface modified to achieve targeting, imaging, and prolonged circulation time, making them suitable for cancer-related research.
Biochemical Assay Reagents  
Cancer  
/
HY-N8380 (-)-Latifolin
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.
Apoptosis   PI3K   Autophagy   Necroptosis  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-125849 Chrysin 7-O-beta-gentiobioside
Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) is the glycosylation product of Chrysin.
Drug Derivative  
Cancer  
/
HY-N10626 Neu5Gcα(2-6) N-Glycan
Neu5Gcα(2-6) N-Glycan is an glycan. Neu5Gcα(2-6) N-Glycan can be used for the various biochemical studies.
Biochemical Assay Reagents  
/
HY-B1234S Octinoxate-13C,d3
Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
Cytochrome P450   Thyroid Hormone Receptor   Androgen Receptor   Estrogen Receptor/ERR   Isotope-Labeled Compounds  
Metabolic or Endocrine Disease  
/
HY-P991756 Anti-Mouse CD44 Antibody (KM703)
Anti-Mouse CD44 Antibody (KM703) recognizes mouse CD44. CD44 is the main receptor for hyaluronan (HA). Anti-Mouse CD44 Antibody (KM703) does not recognize the HA binding site of CD44. Anti-Mouse CD44 Antibody (KM703) is a non-HA-blocking antibody. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).

Species: Mouse

CD44  
Cancer  
/
HY-P990847 Anti-E-Selectin Antibody (CL2)
Anti-E-Selectin Antibody (CL2) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human E-Selectin. Anti-E-Selectin Antibody (CL2) reacts with human E-selectin also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), and leukocyte-endothelial cell adhesion molecule 2 (LECAM2). Anti-E-Selectin Antibody (CL2) directly blocks the binding of E selectin to carbohydrate ligands. Anti-E-Selectin Antibody (CL2) can be used for the detection of flow cytometry.

Species: Human

E-Selectin  
Inflammation or Immune System Disease  
/
HY-N2110R Phellopterin (Standard)
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
Reference Standards   Akt   Sirtuin   Integrin   STAT   PI3K   Apoptosis   ERK   PPAR   PKC   Toll-like Receptor (TLR)   HIV  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-19344S Lifitegrast-d4
Lifitegrast-d4 (SAR 1118-d4) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-19344S2 Lifitegrast-d4-1
Lifitegrast-d4-1 is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
Isotope-Labeled Compounds   Integrin  
Inflammation or Immune System Disease  
/
HY-131300 Colchicoside
Colchicoside is a monoglycosylated colchicine alkaloid glycoside with anti-leishmanial activity. Colchicoside can be obtained by specific glycosylation of Colchicine (HY-16569) by Astragalus vesicarius plant suspension cells, and is also found in Gloriosa superba seeds. Colchicoside can serve as a precursor for the synthesis of Thiocolchicoside (HY-N0301). Colchicoside can be used in research related to anti-leishmanial infection.
Parasite   Drug Derivative   Drug Intermediate  
Leishmania Infection  
/
HY-P3448S Certepetide-13C6,15N2
Certepetide-13C6,15N2 (CEND-1-13C6,15N2) is the 13C- and 15N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
Isotope-Labeled Compounds   Integrin   Complement System  
/
HY-16304 Mannose 1-phosphate
Mannose 1-phosphate is a phosphorylated mannose that serves as a precursor of GDP-mannose, a constituent unit of glycosylation biosynthetic pathways. Mannose 1-phosphate increases intracellular GDP-mannose concentration, promotes normalization of lipid-linked oligosaccharide structures, and enhances the formation of mature N-glycans on cellular proteins. Mannose 1-phosphate can be used in studies related to glycosylation disorders.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N3262 Methylisopelletierine
Methylisopelletierine is a piperidine alkaloid found in the leaves and stem barks of Punica granatum. It serves as the direct biosynthetic precursor of pseudopelletierine and can undergo cyclization to form pseudopelletierine. Methylisopelletierine can be used in studies related to colorectal cancer.
Others  
Colorectal Cancer  
/
HY-P991341 FF-21101
FF-21101 is a human IgG1 monoclonal antibody (mAb) targeting CDH3/P-cadherin. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Cadherin  
Inflammation or Immune System Disease  
/
HY-N15201 Betavulgarin
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44+/CD24− subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling.
STAT  
Breast Cancer  
/
HY-P991559 Anti-CD44 Antibody
Anti-CD44 Antibody (VB6-008 antibody) is an IgG1 monoclonal antibody against CD44, which can be used in the study of cancer.

Species: Human

CD44  
Cancer  
/
HY-B0579S1 Cyclosporin A-d3
Cyclosporin A-d3 (Cyclosporine A-d3) is the deuterated-labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.
Isotope-Labeled Compounds   Molecular Glues   Complement System   Antibiotic   Cyclophilin  
Neurological, Eye or Ear Disease   Breast Cancer   Prostate Cancer   Viral Infection   Autoimmune Disease   SARS-CoV-2 Infection   Lung Fibrosis  
/
HY-N2013R Aristolactam I (Standard)
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.
Reference Standards   Caspase   Apoptosis  
Inflammation or Immune System Disease  
/
HY-N10628 Neu5Acα(2-6) N-Glycan
Neu5Acα(2-6) N-Glycan is a N-Glycan, and can be used for labeling and modification of proteins.

Source: human serotransferrin

Biochemical Assay Reagents  
/
HY-N14886 Pyridindolol K2
Pyridindolol K2 is an alkaloid antibiotic found in Str. Sp. K93-0711. Pyridindolol K2 can inhibit the adhesion of HL-60 cells.
Antibiotic   Bacterial  
Infection  
/
HY-P3448S1 Certepetide-13C2,15N
Certepetide-13C2,15N (CEND-1-13C2,15N) is the 13C- and 15N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
Isotope-Labeled Compounds   Integrin   Complement System  
/
HY-119684S Maresin 2
Maresin 2-d5 is the d5-labeled Maresin 2 (HY-119684). Maresin 2 is an anti-inflammatory and pro-resolving mediator. Maresin 2 drives intestinal epithelial cell migration by activating the focal cell-matrix adhesion signaling pathway in primary human intestinal epithelial cells, thereby promoting mucosal wound repair. Maresin 2 alleviates nociceptive and anxiety-like behaviors in rats with type 1 diabetes by inhibiting IL-1β in the spinal cord and prefrontal cortex. Maresin 2 attenuates allergic airway inflammation in mice by inhibiting the activation of the NLRP3 inflammasome, Th2-type immune responses, and oxidative stress. Maresin 2 inhibits inflammatory and neuropathic trigeminal neuralgia and reduces neuronal activation in the trigeminal ganglion. Maresin 2 promotes inflammation resolution and mucosal repair after DSS-induced colitis or biopsy-induced colonic mucosal injury.
Isotope-Labeled Compounds   NOD-like Receptor (NLR)   Interleukin Related  
Digestive System Disease   Anxiety or Fear-Related Disease   Pain   Colitis  
/
HY-152003S Ganglioside GM2-d3 ammonium
Ganglioside GM2-d3 (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling.
Isotope-Labeled Compounds  
/
HY-122552 Chrysotobibenzyl
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394).
Integrin  
/
HY-111413 c(phg-isoDGR-(NMe)k)
c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM.
Integrin  
Cancer  
/
HY-W047324 4-Aminophenyl-α-D-mannopyranoside, 98%
4-Aminophenyl-α-D-mannopyranoside, 98% is a synthetic glycoside primarily used as a molecular tool in biochemical research for studying glycosylation processes and enzyme-substrate interactions.
Biochemical Assay Reagents  
/
HY-N7486 Chamaejasmenin B
Chamaejasmenin B can be extracted from Stellera chamaejasme L. Chamaejasmenin B suppresses cancer cells migration and invasion. Chamaejasmenin B inhibits tumor metastasis. Chamaejasmenin B can be used in the research of cancers, such as breast cancers.
Others  
/
HY-P991644 IMGN388 Antibody
IMGN388 Antibody is an Integrin targeting humanized monoclonal antibody. IMGN388 Antibody can be used for synthesis ADCs.

Species: Human

Integrin   ADC Antibodies  
Cancer  
/
HY-P5352 Hyaluronan-IN-1
Hyaluronan-IN-1 (Pep-1) is a Hyaluronan inhibitor with a Kd value of 1.65 μM. Hyaluronan-IN-1 blocks CD44-dependent cell adhesion. Hyaluronan-IN-1 inhibits cell adhesion to hyaluronan substrates. Hyaluronan-IN-1 suppresses the development of contact hypersensitivity in mice by blocking the homing process of inflammatory cells to the skin. Hyaluronan-IN-1 also inhibits responses during the sensitization phase. Hyaluronan-IN-1 reduces lung metastasis of melanoma and prolongs the survival of mice. Hyaluronan-IN-1 can be used in research related to contact hypersensitivity, chronic skin inflammation, and melanoma.
CD44  
Allergy   Cancer Immunology   Immunotherapy for Melanoma  
/
HY-111413A c(phg-isoDGR-(NMe)k) TFA
c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM.
Integrin  
Cancer  
/
HY-N6737 Aureothricin
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin.

Source: Streptomyces kasugaensis

Bacterial   Antibiotic  
Infection  
/
HY-N1480S (-)-Fucose-13C
(-)-Fucose-13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti
Isotope-Labeled Compounds   Endogenous Metabolite   Parasite  
Infection   Metabolic or Endocrine Disease  
/
HY-W415798 Ac4GalNAlk
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers.
Endogenous Metabolite  
/
HY-139201H Poly-D-lysine hydrobromide (MW ≥300000)
Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide.
CaSR  
/
HY-D2836A FITC-HA (MW 500000)
FITC-HA (MW 500000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-158482 M3 glycan (Man3)
M3 glycan (Man3) (Mannose-3 N-linked oligosaccharide; Oligomannose 3 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans.
Biochemical Assay Reagents  
/
HY-158470 Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labelled
Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is a 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 2. Disialylated Core 2 O-glycan (C2S(3,3)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-158469 Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled
Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is a disialylated, 2-AB (2-aminobenzamide) labeled O-linked glycan with core structure 1 (MUC1-M). Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labeled is related to sialylation and participates in life activities including cell recognition, protection, immune regulation and disease markers.
Biochemical Assay Reagents  
/
HY-P990362 Anti-CDH1/E-cadherin/CD324 Antibody
Anti-CDH1/E-cadherin/CD324 Antibody is a humanized antibody expressed in CHO, targeting CDH1/E-cadherin/CD324. The Anti-CDH1/E-cadherin/CD324 Antibody contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 146.6 kDa. The isotype control for Anti-CDH1/E-cadherin/CD324 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Cadherin  
Inflammation or Immune System Disease  
/
HY-W015860 3-Methylbenzene-1,2-diamine
3-Methylbenzene-1,2-diamine (Tolylene-2,3-diamine) is a CD44 hyaluronic acid-binding domain ligand, with a Kd of 8.5 mM for hCD44 HABD and a Kd of 6.4 mM for mCD44 HABD. 3-Methylbenzene-1,2-diamine acts as a non-inhibitor that does not interfere with the binding of CD44 HABD to polymeric hyaluronic acid in vitro.
CD44  
/
HY-123023 12(S)-HETE-d8
12(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. 12(S)-HETE-d8 is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS). 12(S)-HETE-d8 is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.
Isotope-Labeled Compounds   DNA/RNA Synthesis   p38 MAPK   ERK  
Cancer  
/
HY-P991660 ARGX-111
ARGX-111 is an anti-MET antibody. ARGX-111 blocks HGF-dependent and -independent signaling, downregulating MET expression on the tumor cell surface. ARGX-111 depletes MET-expressing circulating tumor cells through enhanced antibody-dependent cell-mediated cytotoxicity (ADCC), thereby inhibiting tumor metastasis. ARGX-111 depletes circulating tumor cells and inhibits bone and lung metastasis in an orthotopic mouse model of metastatic breast cancer. ARGX-111 is promising for research in breast cancer and other cancers.

Species: Human

c-Met/HGFR  
Breast Cancer  
/
HY-N9454 Garcinoic acid
Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2, porcine α-amylase, Saccharomyces cerevisiae α-glucosidase and human DNA polymerase β (IC50=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia.
Pregnane X Receptor (PXR)   COX   NF-κB   Amylases   β-glucuronidase   DNA/RNA Synthesis   Amyloid-β   NOD-like Receptor (NLR)   Pyroptosis  
Cancer  
/
HY-N19791 6-Methoxymellein
6-Methoxymellein, a phytoalexin, is a NF-κB inhibitor. 6-Methoxymellein reduces nuclear localization and DNA binding activity of NF-κB p65 and p50 subunits. 6-Methoxymellein decreases mRNA transcription and secretion of IL-6 and IL-8. 6-Methoxymellein reduces the proportion of CD44+/CD24− breast cancer cells, decreases expression of c-Myc, Sox-2 and Oct4, inhibits proliferation and migration of breast cancer cells, and reduces mammosphere growth. 6-Methoxymellein inhibits fungal growth of Trichophyton rubrum and Botrytis cinerea, and inhibits Trichophyton rubrum biofilm formation via hyphal disintegration. 6-Methoxymellein can be used for the research of breast cancer, tinea corporis, and carrot post-harvest storage rot.
NF-κB   Fungal   Interleukin Related  
Breast Cancer   Fungal Infection  
/
HY-B0633E Hyaluronic acid, low endotoxin
Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating disaccharide units containing low levels of endotoxin. Hyaluronic acid is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid activates PI3K-Akt signaling. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid can lubricate the corneal endothelium. Hyaluronic acid can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases.
Endogenous Metabolite   CD44   Bacterial   Akt   PI3K  
Cancer   Inflammation or Immune System Disease   Visual System Disease   Liver Disease   Osteoarthritis  
/
HY-P990082 Suvemcitug
Suvemcitug (APX-003) is a selective humanized rabbit monoclonal IgG1 (κ) anti-VEGF antibody. Suvemcitug inhibits the binding of VEGF to purified VEGFR1 (IC50 = 21.0 ng/mL) and VEGFR2 (IC50 = 275.4 ng/mL). Suvemcitug suppresses tumor angiogenesis, tumor growth and metastasis. Suvemcitug is applicable to research related to epithelial ovarian cancer, fallopian tube cancer and primary peritoneal cancer.

Species: Human

VEGFR  
Blood or Cardio-cerebrovascular Disease   Epithelial Ovarian Cancer  
/
HY-P11017 LNSMGQD
LNSMGQD is a cyclic peptide fragment derived from desmoglein 1 (amino acids 81-86), which mimics trans-interactions and acts as part of the tandem peptide binding interface of desmoglein 2. LNSMGQD not only binds to desmoglein 1 and 3, but also effectively inhibits their homophilic trans-interactions, while reducing the probability of homophilic or heterophilic binding between desmoglein 2 and Dsc2, N-cadherin and E-cadherin. LNSMGQD is applicable to the research on disease mechanisms such as Crohn's disease and pemphigus vulgaris.
p38 MAPK   Cadherin  
Digestive System Disease   Digestive System Inflammation   Crohn's Disease  
/
HY-W713284 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate
2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
Isotope-Labeled Compounds   Androgen Receptor   Estrogen Receptor/ERR   Cytochrome P450   Thyroid Hormone Receptor  
Metabolic or Endocrine Disease  
/
HY-W540687 Disialyloctasaccharide
Disialyloctasaccharide is a class of biochemical reagents used in glycobiology research. Disialyloctasaccharide serves as an internal standard for serum glycomics analysis, including absolute quantification of N-glycans and quantification of serum sialylated glycans via MALDI-TOF/MS. Disialyloctasaccharide can be applied to research related to hepatocellular carcinoma.
Biochemical Assay Reagents  
Liver Cancer  
/
HY-D2439 RGD-PEG-Cy3
RGD-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, peptide (RGD) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. RGD is a peptide sequence (CRGDKGPDCiRGD) that binds to αvβ3 and αvβ5 integrin receptors on tumor neovasculogenesis to achieve specific tumor tissue targeting.
Fluorescent Dye  
/
HY-P991342 CQY684
CQY684 (PCA062 antibody) is a monoclonal antibody targeting CDH3/P-cadherin, which locks P-cadherin in an X-dimer conformation and enhances the stability of this adhesion structure. CQY684 induces P-cadherin phosphorylation and promotes its dissociation from the cytoplasmic region of P-cadherin. As an endocytosis inducer and lysosome-targeting agent, CQY684 facilitates the internalization of the P-cadherin-CQY684 complex and improves the turnover efficiency of P-cadherin. CQY684 serves as a platform for the delivery of intracellular anticancer compounds, which is achieved through the targeted lysosomal transport of the antibody-P-cadherin complex. CQY684 is applicable to the research of breast cancer, esophageal cancer, and head and neck cancer.

Species: Human

Cadherin  
Breast Cancer   Esophageal Cancer  
/
HY-P99560 Tadocizumab
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research.

Species: Human

Integrin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P99324 Tomuzotuximab
Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects.

Species: Human

EGFR   Apoptosis  
Cancer  
/
HY-P99946 Erlizumab
Erlizumab (rhuMAb) is a monoclonal antibody against the Integrin b2/ITGB2/CD18 subunit of the Mac-1 receptor. Erlizumab can reduce reperfusion injury in myocardial infarction.

Species: Human

Integrin  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Breast Cancer  
/
HY-P0095 Acetyl tetrapeptide-5
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care.
Angiotensin-converting Enzyme (ACE)  
/
HY-P5232 Tetrapeptide-21
Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin). Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient.
Collagen  
Metabolic or Endocrine Disease  
/
HY-W134005 Mg(Ⅱ)-EDTA disodium tetrahydrate
Mg(Ⅱ)-EDTA (Ethylenediaminetetraacetic acid magnesium) disodium tetrahydrate is a divalent metal chelator and ferroptosis inducer. Mg (Ⅱ)-EDTA disodium tetrahydrate reduces E-cadherin expression by chelating Ca2+ on the surface of tumor cells, thereby triggering cell dissociation and inducing epithelial-mesenchymal transition (EMT). Mg (Ⅱ)-EDTA disodium tetrahydrate further chelates lysosomal iron to form EDTA-Fe, induces ferroptosis through the Fenton reaction, and synergistically enhances immune responses to inhibit tumor metastasis. Mg (Ⅱ)-EDTA (disodium tetrahydrate) can be used in tumor-related research.
Ferroptosis   Cadherin  
/
HY-W674039 6-Azido-6-deoxy-D-glucose, 95%
6-Azido-6-deoxy-D-glucose, 95% is used for visualizing protein-specific glycosylation in living cells.
Biochemical Assay Reagents  
/
HY-P991646 ING-1
ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers.

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-P10887 Pegevongitide
Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.
Tie   ANGPTL   SARS-CoV   Aquaporin   TNF Receptor   PAI-1   CXCR   P-selectin  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   SARS-CoV-2 Infection  
/
HY-41588 2,3,4,6-Tetra-O-acetyl-D-glucopyranose, 96%
2,3,4,6-Tetra-O-acetyl-D-glucopyranose, 96% can be used in simulated glycosylation experiments.
Biochemical Assay Reagents  
/
HY-P3726 Lys-Gln-Ala-Gly-Asp-Val
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs).
Integrin  
Cancer   Inflammation or Immune System Disease  
/
HY-106275 FX-06
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS).
Flavivirus   Dengue Virus  
Blood or Cardio-cerebrovascular Disease  
/
HY-W718137 6-Azido-6-deoxy-D-galactose, 95%
6-Azido-6-deoxy-D-galactose, 95% can be used as a substrate in enzymology to study the activity and specificity of galactosyltransferases and other glycosylation enzymes.
Biochemical Assay Reagents  
/
HY-P991723 Varsetatug
Varsetatug (CX-2051 antibody) is a humanized IgG1κ monoclonal antibody inhibitor targeting EpCAM/TROP1/CD326. Varsetatug serves as the antibody component of the ADC compound CX-2051. It can be used in research on cancers including breast cancer, prostate cancer and ovarian cancer.

Species: Human

ADC Antibodies   Transmembrane Glycoprotein  
Breast Cancer   Prostate Cancer   Ovarian Cancer  
/
HY-P990656 RG-6125
RG-6125 is a humanized antibody expressed in CHO, targeting CDH11/Cadherin-11. RG-6125 has a huIgG2 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for RG-6125 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Species: Human

Others  
Inflammation or Immune System Disease  
/
HY-P5098 E(c(RGDfK))2
E (c (RGDfK)) 2 is a αvβ3 integrin ligand and tumor-targeting agent. E (c (RGDfK)) 2 binds to αvβ3 integrin, mediates receptor-mediated endocytosis of conjugated payloads, and inhibits integrin-dependent cell adhesion to fibrinogen. E (c (RGDfK)) 2 inhibits the proliferation of cancer cells and endothelial cells. E (c (RGDfK)) 2 preferentially accumulates in orthotopic mouse breast tumors and human ovarian cancer xenograft tumors. E (c (RGDfK)) 2 can be used in research related to glioblastoma, lung cancer, breast adenocarcinoma and ovarian cancer.
Integrin  
Lung Cancer   Breast Cancer   Ovarian Cancer   Glioblastoma  
/
HY-P4104 pVEC (Cadherin-5)
pVEC (Cadherin-5) is a cell-penetrating 18-amino acid-long peptide derived from the murine sequence of the cell adhesion molecule vascular endothelial cadherin. pVEC (Cadherin-5) is efficiently and rapidly taken up into cells, it can be used as a carrier peptide.
Others  
/
HY-P6442 Chemerin15
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury.
Chemerin Receptor   Syk   ERK   Src   p38 MAPK   P-selectin  
Cerebrovascular Disease   Cardiovascular Disease   Ischemia-Reperfusion Injury  
/
HY-P990645 PF-03732010
PF-03732010 is a humanized antibody expressed in CHO, targeting CDH3/P-cadherin. PF-03732010 has a huIgG1 type heavy chain and a huλ type light chain, with a predicted molecular weight (MW) of 142.7 kDa. The isotype control for PF-03732010 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Cadherin  
Inflammation or Immune System Disease  
/
HY-P99443 Aselizumab
Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma.

Species: Human

P-selectin  
Inflammation or Immune System Disease  
/
HY-P1189A Echistatin TFA
Echistatin TFA is a naturally derived RGD-containing snake venom peptide. Echistatin TFA exhibits an IC50 of 0.6 nM against mouse αvβ3 integrin, and acts as an antagonist against αvβ3, αIIbβ3, α5β1 integrins, pp125FAK and paxillin. Echistatin TFA reduces the phosphorylation of pp125FAK and paxillin, inhibits the autophosphorylation and kinase activity of pp125FAK, and weakens its binding to pp60src and paxillin. Echistatin TFA disrupts the actin cytoskeleton and focal adhesions, induces melanoma cell detachment from fibronectin, and regulates cell adhesion and motility. Echistatin TFA inhibits osteoclast maturation and migration, bone resorption, platelet aggregation, bone loss, as well as adhesion and metastasis of Lewis lung cancer cells; it also increases the number of osteoclasts and bone coverage area in mice with secondary hyperparathyroidism. Echistatin TFA can be used in research related to melanoma, lung cancer and secondary hyperparathyroidism.

Source: snake venoms

Integrin  
Melanoma   Hyperparathyroidism  
/
HY-176559 LacNAc-VC-PAB-MMAE
LacNAc-VC-PAB-MMAE is a component of an Antibody-Drug Conjugate (ADC). LacNAc-VC-PAB-MMAE is assembled onto the N-glycosylation site of Trastuzumab (HY-P9907) by WT Endo-S2.
Drug-Linker Conjugates for ADC  
Cancer  
/
HY-N10534 Lewis X trisaccharide
Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis.

Source: human

Parasite  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-P11288A ANT308 TFA
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 TFA significantly enhances the activation and proliferation of T cells. ANT308 TFA inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 TFA can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM).
PACAP Receptor   Apoptosis  
/
HY-34666 (4S)-4-Hydroxy-D-proline
(4S)-4-Hydroxy-D-proline is a D-proline derivative and aglycon core for synthesis of cell wall O-glycans of the green alga Chlamydomonas reinhardtii.
Amino Acid Derivatives  
/
HY-P5351A Hyaluronan-binding peptide, biotin labeled TFA
Hyaluronan-binding peptide, biotin labeled TFA is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.).
Transmembrane Glycoprotein  
Cancer   Inflammation or Immune System Disease  
/
HY-P1189 Echistatin
Echistatin is a naturally derived RGD-containing snake venom peptide. Echistatin exhibits an IC50 of 0.6 nM against mouse αvβ3 integrin, and acts as an antagonist against αvβ3, αIIbβ3, α5β1 integrins, pp125FAK and paxillin. Echistatin reduces the phosphorylation of pp125FAK and paxillin, inhibits the autophosphorylation and kinase activity of pp125FAK, and weakens its binding to pp60src and paxillin. Echistatin disrupts the actin cytoskeleton and focal adhesions, induces melanoma cell detachment from fibronectin, and regulates cell adhesion and motility. Echistatin inhibits osteoclast maturation and migration, bone resorption, platelet aggregation, bone loss, as well as adhesion and metastasis of Lewis lung cancer cells; it also increases the number of osteoclasts and bone coverage area in mice with secondary hyperparathyroidism. Echistatin can be used in research related to melanoma, lung cancer and secondary hyperparathyroidism.

Source: snake Echis carinatus

Integrin  
Melanoma   Hyperparathyroidism  
/
HY-W011338S Benzyl butyl phthalate-d4
Benzyl butyl phthalate-d4 is the deuterium labeled Benzyl butyl phthalate. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs).
Aryl Hydrocarbon Receptor  
/
HY-P991108 Anti-CDH6/K-Cadherin Antibody
Anti-CDH6/K-Cadherin Antibody (HKT288 antibody) is a human antibody expressed in CHO cells, targeting CDH6. Anti-CDH6/K-Cadherin Antibody (HKT288 antibody) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-W654264 2-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine chloride (2MBC chloride) is an orally active short-chain branched-chain acylcarnitine and a gut microbiota co-metabolite produced from 2-methylbutyric acid via branched-chain amino acid catabolism. 2-Methylbutyrylcarnitine chloride activates platelet integrin α2β1 (Kd = 10.6 μM), initiates the downstream p38‑cPLA2 signaling cascade, elevates TXA2 production, and thereby enhances platelet hyperreactivity. 2-Methylbutyrylcarnitine chloride can be used in research on atherosclerosis and thrombosis.
Endogenous Metabolite   Drug Metabolite   Integrin   Phospholipase  
Digestive System Inflammation   Cardiovascular Disease   Atherosclerosis and Inflammation  
/
HY-P990201 Anti-Mouse L-Selectin/CD62L Antibody (Mel-14)
Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is an anti-mouse L-Selectin/CD62L IgG2a monoclonal antibody. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can significantly inhibit the migration of T cells and B cells. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can block initial lymphocyte homing. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can be used for researches on inflammation, metabolic and infection conditions such as diabetes and parasitic infections.

Species: Mouse

L-Selectin  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P99184 Abrilumab
Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD).

Species: Human

Integrin  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-NP163E Wheat germ agglutinin-AF647
Wheat germ agglutinin-AF647 (WGA-AF647) is a plant lectin that contains the fluorescent dye AF647, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF647 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA.
Fluorescent Dye  
Cancer  
/
HY-100133A DOTA-ADIBO TFA
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator (BFC) that allows drug conjugation via an uncatalyzed, copper-free cycloaddition reaction. DOTA-ADIBO TFA enables the construction of fusion chelator systems that can be further used to synthesize radiotracers after Cu[64] modification. Positron emission tomography imaging of tumors expressing integrin αvβ6.
Integrin  
Cancer  
/
HY-P1613A Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia.
Integrin   Apoptosis  
/
HY-132828 Odatroltide
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities.
P-selectin  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-126437D Poly-L-lysine hydrobromide (MW ＞300000)
Poly-L-lysine hydrobromide (MW 150000-300000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine hydrobromide (MW 150000-300000) has good biocompatibility. Poly-L-lysine hydrobromide (MW 150000-300000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface.
Biochemical Assay Reagents  
/
HY-B2162D Chondroitin sulfate (from chicken)
Chondroitin sulfate (from chicken) (Chondroitin polysulfate (from chicken)) is an orally active, sulfated linear polysaccharide extracted from chickens, which belongs to glycosaminoglycans. Chondroitin sulfate (from chicken) reduces the phosphorylation levels of ERK1/2 and p38MAPK, inhibits the expression of inflammatory cytokines and MMP, and downregulates the levels of IL-1β, IL-6, TNF-α and PGE2. Chondroitin sulfate (from chicken) improves motor function, protects cartilage tissue, reverses chondrocyte aggregation, and regulates the structure of intestinal flora. Chondroitin sulfate (from chicken) can be used in research related to osteoarthritis.
ERK   p38 MAPK   Interleukin Related   TNF Receptor   Prostaglandin Receptor   MMP   Endogenous Metabolite  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P991558 RO-5429083
RO-5429083 (RG-7356) is a humanized monoclonal antibody targeting CD44. RO-5429083 binds to the extracellular domain of CD44 and inhibits constitutive EGFR phosphorylation. RO-5429083 suppresses tumor growth in xenograft models and can be used in research related to head and neck squamous cell carcinoma and acute myeloid leukemia.

Species: Human

Transmembrane Glycoprotein  
Leukemia/Lymphoma/Myeloma   Squamous Cell Carcinoma  
/
HY-NP175 Collagen (bovine skin)
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development.
Biochemical Assay Reagents   Integrin   Discoidin Domain Receptor  
/
HY-P5755 SWELYYPLRANL-NH2
SWELYYPLRANL-NH2 is an E-cadherin and N-cadherin antagonist. SWELYYPLRANL-NH2 inhibits phage clone binding to E- or N-cad/Fc chimeric protein (IC50: 0.7 and 0.09 μM respectively). SWELYYPLRANL-NH2 inhibits cell aggregation. SWELYYPLRANL-NH2 can be used to promote drug delivery through epithelial and endothelial permeability barriers.
Others  
Cancer  
/
HY-P991487 LASN01
LASN01 is a humanized antibody targeting IL-11R, with a Kd of 37 pM. LASN01 blocks the IL-11 signaling pathway via IL-11Rα, and inhibits the phosphorylation of STAT3 and ERK, as well as the expression of pro-inflammatory cytokines, hyaluronic acid, procollagen and fibrotic markers. LASN01 can be used in studies related to thyroid eye disease.

Species: Human

/
HY-N3677 Dammarenediol II
Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy.
OGT   Akt   mTOR   GSK-3   Reactive Oxygen Species (ROS)   Apoptosis   PARP   MDM-2/p53  
Liver Cancer   Autoimmune Disease  
/
HY-NP0196 Mouse immunoglobulin G
Mouse Immunoglobulin G (Mouse IgG) is the most abundant glycoprotein in mouse serum, which bridges innate and adaptive immune responses. A conserved asparagine-297 residue on each heavy chain contains an N-linked glycosylation site. Mouse Immunoglobulin G shares many glycosylation features with human IgG, but contains N-Glycolylneuraminic acid (HY-128965) instead of N-acetylneuraminic acid (HY-I0400). Mouse Immunoglobulin G is widely used as a negative isotype control, immunoassay coating protein and research standard in the life sciences.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-W008201 tert-Butyl 3-formylpyrrolidine-1-carboxylate
tert-Butyl 3-formylpyrrolidine-1-carboxylate is a drug intermediate that can be used for the synthesis nonpeptidic αvβ6 Integrin inhibitors.
Drug Intermediate  
Inflammation or Immune System Disease  
/
HY-B0633D Hyaluronic acid sodium (MW 200-1560)
Hyaluronic acid sodium (MW 200-1560) is a biopolymer composed of repeating disaccharide units, with a molecular weight of 200-1560. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid sodium exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid sodium activates PI3K-Akt signaling. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid sodium is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid sodium can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid sodium can lubricate the corneal endothelium. Hyaluronic acid sodium can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid sodium has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid sodium can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases.
CD44   Endogenous Metabolite   Bacterial   Akt   PI3K  
Cancer   Inflammation or Immune System Disease   Visual System Disease   Liver Disease   Osteoarthritis  
/
HY-P99697 Leronlimab
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.

Species: Human

CCR   HIV  
Cancer   Infection  
/
HY-P99296 Intetumumab
Intetumumab (CNTO 95) is a human monoclonal antibody targeting αv integrin, with a Kd value of 1-24 nM. Through high-affinity binding to αv integrin, Intetumumab inhibits its interaction with extracellular matrix proteins (such as vitronectin and fibronectin), thereby blocking the downstream focal adhesion kinase signaling pathway. This further inhibits the adhesion, migration and invasion of tumor cells as well as the proliferation of vascular endothelial cells, promotes cell apoptosis, and exerts anti-tumor and anti-angiogenic effects. Intetumumab can be used in research related to head and neck cancer, non-small cell lung cancer and uterine serous papillary carcinoma.

Species: Human

Integrin   Apoptosis  
Cancer  
/
HY-P99788 Praluzatamab
Praluzatamab is a monoclonal antibody targeting the activated leukocyte cell adhesion molecule (ALCAM/CD116). Praluzatamab can be used to synthesize Praluzatamab ravtansine (antibody-drug conjugates). Praluzatamab can be used for research of cancers.

Species: Human

ADC Antibodies   ALCAM/CD166  
Cancer  
/
HY-B1234 Octinoxate
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
Environmental Pollutants   Cytochrome P450   Androgen Receptor   Estrogen Receptor/ERR   Thyroid Hormone Receptor  
Metabolic or Endocrine Disease   Digestive System Disease   Breast Cancer   Digestive System Inflammation  
/
HY-P10941A VSLRGDTRG acetate
VSLRGDTRG acetate is a synthetic peptide containing the RGD motif from cadherin 17 (CDH17), which binds to α2β1 integrin and activates its signaling pathway. VSLRGDTRG acetate promotes the high-affinity conformational change of β1 integrin through the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. VSLRGDTRG acetate can be used in research on cancers expressing CDH17, such as colon cancer and pancreatic cancer.
Integrin   ERK   FAK  
Inflammation or Immune System Disease  
/
HY-14596S Genistein-d4
Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
EGFR   Autophagy   Apoptosis   Endogenous Metabolite  
Cancer  
/
HY-P991100 Anti-CDH17/Cadherin-17 Antibody (10C12)
Anti-CDH17/Cadherin-17 Antibody (10C12) is a human antibody expressed in CHO cells, targeting CDH17/Cadherin-17. Anti-CDH17/Cadherin-17 Antibody (10C12) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001). Anti-CDH17/Cadherin-17 Antibody (10C12) can be used in the study of cancer.

Species: Human

Cadherin  
Cancer  
/
HY-P99781 Plozalizumab
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

CCR  
Cancer   Inflammation or Immune System Disease  
/
HY-P99322 Tesidolumab
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex.

Species: Human

Complement System  
Inflammation or Immune System Disease  
/
HY-B0633B Hyaluronic acid (MW 50000-100000)
Hyaluronic acid (MW 50000-100000) (Hyaluronan (MW 50000-100000)) is a biopolymer composed of repeating units of disaccharides with a molecular weight of 50000-100000 Da. Hyaluronic acid (MW 50000-100000) can be used as a drug carrier for drug delivery.
Biochemical Assay Reagents   PI3K  
/
HY-N2110 Phellopterin
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
Akt   Sirtuin   Integrin   STAT   PI3K   Apoptosis   ERK   PPAR   PKC   Toll-like Receptor (TLR)   HIV  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Digestive System Inflammation   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
/
HY-D2836 FITC-HA (MW 1000000)
FITC-HA (MW 1000000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).
Fluorescent Dye  
/
HY-P10586A Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL).
Toll-like Receptor (TLR)   NO Synthase  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-150287A Insulin-Transferrin-Selenium-Ethanolamine
Insulin-Transferrin-Selenium-Ethanolamine (ITS-X) is a cell culture supplement as well as a cell growth and adhesion promoter. Insulin-Transferrin-Selenium-Ethanolamine supports adhesion, pseudopodium formation, pseudopodium elongation and proliferation of adherent cancer cells in serum-free culture systems.
Biochemical Assay Reagents  
/
HY-P3732 RGD-4C
RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models.
Integrin  
Cancer  
/
HY-W040294 Methyl α-D-glucoside
Methyl α-D-glucoside (Methyl α-D-glucopyranoside) can be used for protein glycosylation modification. Methyl α-D-glucoside is a kind of biological materials or organic compounds that are widely used in life science research.
Biochemical Assay Reagents  
/
HY-P1654 A20FMDV2
A20FMDV2 is a highly selective αvβ6 integrin inhibitor with human IC50 values of 3 nM and binds with at least 1000-fold selectivity over other RGD-binding integrins. A20FMDV2 binds to the integrin’s RGD-binding site, induces rapid integrin internalization, and delays post-internalization integrin recycling to the cell surface. A20FMDV2 can be used for the research of pancreatic cancer, breast cancer, colorectal cancer, ovarian cancer, oral squamous cell carcinoma.
Integrin  
Breast Cancer   Colorectal Cancer   Pancreatic Cancer   Ovarian Cancer  
/
HY-P9992 Pelgifatamab
Peligifatamab is a PSMA-targeted α-radioimmunoconjugate with an EC50 of 1.2 nM against human targets. Peligifatamab induces DNA damage, DNA double-strand breaks, cell cycle arrest and apoptosis (Apoptosis) in PSMA-positive prostate cancer cells. Peligifatamab reduces cell viability in a manner dependent on cellular PSMA expression levels. Peligifatamab inhibits tumor growth and tumor-induced abnormal bone growth in prostate cancer bone metastasis models. Peligifatamab exhibits antitumor efficacy in subcutaneous prostate cancer models and xenograft models. Peligifatamab can be used for the research of metastatic castration-resistant prostate cancer.

Species: Human

PSMA   Apoptosis  
Castration-Resistant Prostate Cancer  
/
HY-P3522 REDV
REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV can be used for the research of cell adhesion. REDV is used to study the effects of gene vectors containing REDV on cells.
Integrin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P991728 Zarutatug
Zarutatug (TORL-3-600 antibody) is an IgG1κ humanized antibody targeting cadherin 17 (CDH17). It selectively binds to cell-surface CDH17, triggering endocytosis and trafficking to lysosomes. Zarutatug can be used to construct ADCs, such as TORL-3-600.

Species: Human

Cadherin   ADC Antibodies  
Cancer  
/
HY-B0665 Fibrin
Fibrin is an insoluble protein found in blood that is produced in response to bleeding. As the main component of blood clots, fibrin functions in blood coagulation. Fibrin binds to the integrins ICAM-1, VE-cadherin, αIIbβ3, αMβ2, αvβ3 and α5β1. Fibrin is used in research related to chronic wounds.

Source: bovine blood

Integrin  
Blood Disease  
/
HY-N2587 Irigenin
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.
Integrin   Apoptosis  
Gastric Cancer   Digestive System Inflammation  
/
HY-P10580 Vasculotide
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability. Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury.
Tie   PI3K   Akt   Cadherin   Claudin  
Infection   Blood or Cardio-cerebrovascular Disease   Skin Inflammation  
/
HY-P99281 Bivatuzumab
Bivatuzumab (Anti-CD44 Recombinant Antibody; BIWA 4) is a humanized monoclonal antibody directed against CD44v6. CD44v6 could acts as a sarcoma target for CAR-redirected CIK cells.

Species: Human

Others  
Cancer  
/
HY-P990045 Lixudebart
Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis.

Species: Human

Claudin  
Renal Disease  
/
HY-137042 Cyanine5 alkyne
Cyanine5 alkyne (Alkyne-Cy5) is a fluorescent dye used to label azide proteins and can be used to analyse post-translational modifications of proteins, glycosylation etc. Cyanine5 alkyne can also be used as a mitochondrial OXPHOS inhibitor to inhibit the growth of cancer stem cells (CSC). Cyanine5 alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Oxidative Phosphorylation   Mitochondrial Metabolism  
/
HY-NP132 Recombinant Humanized Type III Collagen 28.6kDa
Recombinant Humanized Type III Collagen 28.6kDa is a 28.6 kDa recombinant humanized type III collagen. Recombinant Humanized Type III Collagen possesses a variety of biological functions, such as promoting the regeneration of the skin extracellular matrix and improving the cellular microenvironment. Recombinant Humanized Type III Collagen can also inhibit the proliferation, migration and invasion of breast cancer cells. Recombinant Humanized Type III Collagen plays a role in cell adhesion, migration, proliferation and differentiation by interacting with Integrin.
Biochemical Assay Reagents   Integrin   Autophagy   Apoptosis   Discoidin Domain Receptor  
Breast Cancer  
/
HY-NP163D Wheat germ agglutinin-AF594
Wheat germ agglutinin-AF594 (WGA-AF594) is a plant lectin that contains the fluorescent dye AF594, which can be used to identify carbohydrate chains. Wheat germ agglutinin-AF594 can be used to assess abnormal glycosylation levels in the body. The specific glycosylation detection sites of Wheat germ agglutinin is bis-GlcNAc, SA.
Fluorescent Dye  
Cancer  
/
HY-P0322 GRGDSPK
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption.
Integrin  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W133898 Tryptone
Tryptone is a peptide-rich bacterial culture medium component that can regulate bacterial cell surface proteins and biofilm-related genes. Tryptone promotes the expression and assembly of bacterial adhesion proteins (such as LapA and LapF) by providing peptide substances as structural factors, enhancing cell surface hydrophobicity and intercellular adhesion, thereby stabilizing the biofilm matrix and supporting the maturation and maintenance of bacterial biofilms. The peptide mixture contained in Tryptone can specifically regulate the transcription of bacterial adhesion-related genes (such as activating LapA and inhibiting LapF), affecting the synthesis and localization of biofilm structural proteins.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-P990363 Anti-CDH17/Cadherin-17 Antibody (PTA001_A4)
Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) is a CHO-expressed human-mouse chimeric antibody targeting CDH17/Cadherin-17. Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) contains an IgG1-type heavy chain and a kappa-type light chain, with a predicted molecular weight (MW) of 149.12 kDa.

Species: Human

Cadherin  
Cancer  
/
HY-112948 2-Methylbutyrylcarnitine
2-Methylbutyrylcarnitine (2MBC) is an orally active short-chain branched-chain acylcarnitine and a gut microbiota co-metabolite produced from 2-methylbutyric acid via branched-chain amino acid catabolism. 2-Methylbutyrylcarnitine activates platelet integrin α2β1 (Kd = 10.6 μM), initiates the downstream p38‑cPLA2 signaling cascade, elevates TXA2 production, and thereby enhances platelet hyperreactivity. 2-Methylbutyrylcarnitine can be used in research on atherosclerosis and thrombosis.
Endogenous Metabolite   Drug Metabolite   Integrin   Phospholipase  
Digestive System Inflammation   Cardiovascular Disease   Atherosclerosis and Inflammation  
/
HY-149898 HA-CD44 interaction inhibitor 1
HA-CD44 interaction inhibitor 1 is a CD44 inhibitor that can inhibit the interaction between Hyaluronic acid (HA) (HY-B0633A) and CD44. HA-CD44 interaction inhibitor 1 exerts an antiproliferative effect on CD44+ cancer cell lines. HA-CD44 interaction inhibitor 1 can be used for the research of cancer.
Transmembrane Glycoprotein   CD44  
Cancer  
/
HY-177434 Precemtabart tocentecan
Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC.
Antibody-Drug Conjugates (ADCs)   Transmembrane Glycoprotein   Topoisomerase  
Cancer  
/
HY-N1480 (-)-Fucose
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth.
Endogenous Metabolite   Parasite  
Cancer   Parasitic Infection   Glucose Metabolism   SARS-CoV-2 Infection  
/
HY-126436A Poly-L-ornithine hydrobromide (MW 30000-70000)
Poly-L-ornithine hydrobromide (MW 30000-70000) is a poly-lysine derivative with a molecular weight of 30000-70000. Poly-L-ornithine hydrobromide (MW 30000-70000) binds to the surface of cell culture vessels through positively charged amino acid residues to form a coating that promotes cell adhesion and provides cells with a matrix environment required for growth. Poly-L-ornithine hydrobromide (MW 30000-70000) is used as a coating agent in cell culture and can be used for the study of primary culture of neurons (such as dopaminergic neurons and oligodendrocytes).
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-131498 Mca-PLGL-Dpa-AR-NH2
MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer.\n
Fluorescent Dye   MMP  
Cancer   Digestive System Cancer   Urogenital Cancer  
/
HY-P74291 CD44 Protein, Mouse (HEK293, His)
The CD44 protein binds to hyaluronic acid and TGF-β receptors and contributes to cytokine function. CD44 is involved in T cell activation, protein phosphorylation, and Wnt signaling and is strategically located in the plasma membrane and microvilli. CD44 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD44 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

CD Antigens B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

/
HY-P72222 HAS2 Protein, Mouse (His)
The HAS2 protein adds GlcNAc or GlcUA monosaccharides to hyaluronic acid, playing a crucial role in its synthesis. HAS2 Protein, Mouse (His) is the recombinant mouse-derived HAS2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Mouse; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

/
HY-P74425 AGER Protein, Mouse (HEK293, His)
AGER proteins have multiple activities, including binding to S100 proteins, advanced glycation end products, and heparin. It is involved in cellular responses to amyloid, regulation of synaptic potentiation, and cytokine production. AGER Protein, Mouse (HEK293, His) is the recombinant mouse-derived AGER protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins

/
HY-P7692 HABP1/C1QBP Protein, Human (His)
HABP1/C1QBP Protein, Human (His) is a recombinant human HABP1 (hyaluronan-binding protein 1)/C1QBP (complement component 1, q subcomponent binding protein) produced in HEK293 cells, with His tag. HABP1/C1QBP is a ubiquitously present glycoprotein having specific affinity towards hyaluronan (HA).

Species: Human; Source: E. coli

Complement System Complement Regulatory Proteins HABP1/C1QBP

/
HY-P70407 ITIH3 Protein, Human (HEK293, His)
The ITIH3 protein has a dual role: as a carrier of hyaluronic acid in serum and as a binding protein that facilitates interactions with various matrix proteins. These interactions regulate the localization, synthesis, and degradation of hyaluronic acid, which is critical for multiple cellular activities. ITIH3 Protein, Human (HEK293, His) is the recombinant human-derived ITIH3 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Protease Inhibitors Inter-Alpha-Trypsin Inhibitors (ITI) ITIH3

/
HY-P74605 AGER Protein, Human (HEK293)
AGER proteins are cell surface pattern recognition receptors that expertly sense endogenous stress signals utilizing an extensive library of ligands, including advanced glycation end products, S100 proteins, high mobility Group Box 1 proteins/HMGB1, starch Like protein β/APP oligomers, nucleic acids, phospholipids, and glycosaminoglycans. AGER Protein, Human (HEK293) is the recombinant human-derived AGER protein, expressed by HEK293 , with tag free.

Species: Human; Source: HEK293

Receptor Proteins

/
HY-P7676 BCAN Protein, Human (HEK293, His)
BCAN Protein, Human (HEK293, His) is a recombinant human brevican core protein produced in HEK293 cells. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a 145-kDa full-length form and an 80-kDa C-terminal fragment.

Species: Human; Source: HEK293

/
HY-P700967 CD44 Protein, Human (242a.a, HEK293, His)
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (242a.a, HEK293, His) is the recombinant human-derived CD44 protein, expressed by HEK293, with C-His labeled tag.

Species: Human; Source: HEK293

CD Antigens B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

/
HY-P74604 AGER Protein, Human (HEK293, hFc)
AGER proteins are cell surface pattern recognition receptors that expertly sense endogenous stress signals utilizing an extensive library of ligands, including advanced glycation end products, S100 proteins, high mobility Group Box 1 proteins/HMGB1, starch Like protein β/APP oligomers, nucleic acids, phospholipids, and glycosaminoglycans. AGER Protein, Human (HEK293, hFc) is the recombinant human-derived AGER protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

/
HY-P70288A MIF Protein, Human (His)
The MIF protein is a pro-inflammatory cytokine that is critical for the innate immune response against bacterial pathogens. Its presence at sites of inflammation suggests a role in modulating macrophage function to promote host defense. MIF Protein, Human (His) is the recombinant human-derived MIF protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Cytokines and Growth Factors

/
HY-P70341 MIF Protein, Mouse (His)
The MIF protein is a pro-inflammatory cytokine that plays a crucial role in the innate immune response against bacterial pathogens.Its presence at sites of inflammation suggests its role as a mediator in the regulation of macrophage function during host defense.MIF Protein, Mouse (His) is the recombinant mouse-derived MIF protein, expressed by E.coli , with C-6*His labeled tag.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors

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HY-P75346 CHL1 Protein, Mouse (HEK293)
CHL1 Protein, Mouse (HEK293) is the recombinant mouse-derived CHL1 protein, expressed by HEK293, with tag free.

Species: Mouse; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs) Immunoglobulin-like Cell Adhesion Molecules Neural Cell Adhesion Molecule L1-Like Protein (CHL1)

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HY-P7823 CEACAM21 Protein, Human (HEK293, His)
CEA21/CEACAM21, a carcinoembryonic antigen (CEA)-related cell adhesion molecule, is expressed on granulocytes. CEACAM21 is also a biological candidate gene for schizophrenia and type I diabetes, with SNPs consistently associated with the disease. CEACAM21 Protein, Human (HEK293, His) is the recombinant human-derived CEACAM21 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs) Immunoglobulin-like Cell Adhesion Molecules CEA Cell Adhesion Molecule 21

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HY-P700402 CD44 Protein, Human (Biotinylated, HEK293, mFc-Avi)
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag.

Species: Human; Source: HEK293

CD Antigens Biotinylated Proteins B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

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HY-P705137 CEACAM5 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)
CEACAM5 protein is a cell surface glycoprotein that cooperates with carcinoembryonic antigen-related molecules (such as CEACAM6) to participate in cell adhesion, intracellular signaling, and tumor progression. CEACAM5, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived CEACAM5 protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.

Species: Cynomolgus; Source: HEK293

CD Antigens Receptor Proteins Biotinylated Proteins Stem Cell CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs) CD66e/CEACAM5 Immunoglobulin-like Cell Adhesion Molecules

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HY-P79168 Hyaluronan Lyase Protein, S. agActiae (His)
Hyaluronate lyase is a polysaccharide-derived carboxylase, also known as a diffusion factor or mucin. This enzyme can cleave hyaluronic acid salts at the β-D-GalNAc-(1→4)-β-D-GlcA glycosidic bond site through a β-elimination reaction, and the resulting unsaturated disaccharide can initiate downstream reaction pathways. Hyaluronan Lyase Protein, S. agActiae (His) is a recombinant hyaluronic acid lyase protein with the N-6*His tag.

Species: Others; Source: E. coli

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HY-P74293 CD44 Protein, Human (HEK293, Fc)
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (HEK293, Fc) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

CD Antigens B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

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HY-P70838 HEPACAM Protein, Human (HEK293, His)
HEPACAM proteins are key regulators of cell motility, interacting with the extracellular matrix to inhibit cell growth and maintain cellular homeostasis. HEPACAM forms homodimers through cis interactions, is a component of the MLC1, TRPV4, AQP4 and ATP1B1 complexes and participates in key molecular interactions. HEPACAM Protein, Human (HEK293, His) is the recombinant human-derived HEPACAM protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs)

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HY-P73024 Ephrin-A1/EFNA1 Protein, Mouse (HEK293, His)
The Ephrin-A1/EFNA1 protein is a GPI-binding ligand critical for migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It binds to nearby Eph receptors, initiating bidirectional signaling. Ephrin-A1/EFNA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Ephrin/Eph Family Ephrins Ephrin-A1

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HY-P75344 CHL1 Protein, Mouse (HEK293, His)
CHL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHL1 protein, expressed by HEK293, with C-His labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs) Immunoglobulin-like Cell Adhesion Molecules Neural Cell Adhesion Molecule L1-Like Protein (CHL1)

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HY-P75345 CHL1 Protein, Mouse (HEK293, hFc)
CHL1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived CHL1 protein, expressed by HEK293, with C-hFc labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins Cell Adhesion Molecules (CAMs) Immunoglobulin-like Cell Adhesion Molecules Neural Cell Adhesion Molecule L1-Like Protein (CHL1)

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HY-P700966 CD44 Protein, Human (242a.a, HEK293, hFc)
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (242a.a, HEK293, hFc) is a recombinant protein dimer complex containing human-derived CD44 protein, expressed by HEK293 , with C-hFc labeled tag. CD44 Protein, Human (242a.a, HEK293, hFc), has molecular weight of 70-100 kDa.

Species: Human; Source: HEK293

CD Antigens B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

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HY-P700146AF Animal-Free AGER Protein, Human (His)
AGER proteins are cell surface pattern recognition receptors that expertly sense endogenous stress signals utilizing an extensive library of ligands, including advanced glycation end products, S100 proteins, high mobility Group Box 1 proteins/HMGB1, starch Like protein β/APP oligomers, nucleic acids, phospholipids, and glycosaminoglycans. Animal-Free AGER Protein, Human (His) is the recombinant human-derived animal-FreeAGER protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Species: Human; Source: E. coli

Receptor Proteins Animal-free Recombinant Proteins

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HY-P700439 CD44 Protein, Macaca fascicularis (HEK293, His)
The CD44 protein is characterized by a lack of conserved residues critical for annotation of propagation signatures. This defective residue in CD44 prevents the propagation of specific functional features associated with this protein. CD44 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived CD44 protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Cynomolgus; Source: HEK293

CD Antigens B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins CD44/ECMR-III

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HY-P701085 AGER Protein, Cynomolgus (HEK293, His)
AGER protein is a cell surface pattern recognition receptor that can sense endogenous stress signals from a variety of ligands, such as S100 protein, HMGB1, β-amyloid, etc. AGER Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived AGER protein, expressed by HEK293 , with C-His labeled tag.

Species: Cynomolgus; Source: HEK293

Receptor Proteins

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HY-P706132 Colicin-E1 Protein, E.coli (Cell-Free, His, Twin-Strep)
Colicin-E1, a channel-forming colicin, serves as a transmembrane toxin inducing cytoplasmic membrane depolarization and cellular energy dissipation. It is part of a broader class of polypeptide toxins synthesized by and active against Escherichia coli and related bacterial strains. Colicin-E1 Protein, E.coli (Cell-Free, His, Twin-Strep) is the recombinant E. coli-derived Colicin-E1 protein, expressed by E. coli Cell-free, with N-10*His, C-Twin-Strep labeled tag.

Species: E.coli; Source: E. coli Cell-free

Receptor Proteins

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HY-P706014 CEMIP Protein, Human (His)

Species: Human; Source: E. coli

Enzymes & Regulators Hydrolases (EC 3)

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HY-P81086 RAGE Antibody
RAGE Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to RAGE.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80602 CD44 Antibody (YA801)
CD44 Antibody (YA801) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD44.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P81086A RAGE Antibody(YA3549)
RAGE Antibody(YA3549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAGE.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P84704 HAS2 Antibody (YA4401)
HAS2 Antibody (YA4401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS2.

Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P86096 RAGE Antibody (YA5788)
RAGE Antibody (YA5788) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAGE.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82566 GC1q R Antibody (YA2311)
GC1q R Antibody (YA2311) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GC1q R.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81080 CEA Antibody (YA917)
CEA Antibody (YA917) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CEA.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86711 CD31 Antibody (YA6403)
CD31 Antibody (YA6403) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CD31.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86478 MIF Antibody (YA6170)
MIF Antibody (YA6170) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MIF.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82699 NrCAM Antibody (YA2444)
NrCAM Antibody (YA2444) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NrCAM.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810439 CD168 Antibody (YA9749)
CD168 Antibody (YA9749) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to CD168.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83786 HAS3 Antibody (YA3483)
HAS3 Antibody (YA3483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P810525 CD168 Antibody (YA9798)
CD168 Antibody (YA9798) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to CD168.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P83060 HAPLN1 Antibody (YA2805)
HAPLN1 Antibody (YA2805) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HAPLN1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83060A HAPLN1 Antibody (YA2805)(PBS only)
HAPLN1 Antibody (YA2805) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HAPLN1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83786A HAS3 Antibody (YA3483)(PBS only)
HAS3 Antibody (YA3483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P84704A HAS2 Antibody (YA4401)(PBS only)
HAS2 Antibody (YA4401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS2.

Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P84998 CD56 Antibody (YA4690)
CD56 Antibody (YA4690) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD56.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Nanobodies Primary Antibodies

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HY-P85009 CD82 Antibody (YA4701)
CD82 Antibody (YA4701) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD82.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Nanobodies Primary Antibodies

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HY-P85083 CD166 Antibody (YA4775)
CD166 Antibody (YA4775) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD166.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86703 CD31 Antibody (YA6395)
CD31 Antibody (YA6395) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD31.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86711A CD31 Antibody (YA6403)(PBS only)
CD31 Antibody (YA6403) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to CD31.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86924 RAGE Antibody(YA6617)
RAGE Antibody(YA6617) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAGE.

Host: Rabbit; Reactivity: Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87282 BRMS1 Antibody (YA6965)
BRMS1 Antibody (YA6965) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRMS1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P89533 CEMIP Antibody (YA8877)
CEMIP Antibody (YA8877) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CEMIP.

Host: Mouse; Reactivity: human

Monoclonal Antibodies Primary Antibodies

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HY-P8F060A FITC-conjugated CD44 Antibody (IM7)
FITC-conjugated CD44 Antibody (IM7) is a Rat-derived and FITC conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F060C PE-conjugated CD44 Antibody (IM7)
PE-conjugated CD44 Antibody (IM7) is a Rat-derived and PE conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F060D PE-Cy7-conjugated CD44 Antibody (IM7)
PE-Cy7-conjugated CD44 Antibody (IM7) is a Rat-derived and PE-Cy7 conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F060I APC-conjugated CD44 Antibody (IM7)
APC-conjugated CD44 Antibody (IM7) is a Rat-derived and APC conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F060J APC-Cy7-conjugated CD44 Antibody (IM7)
APC-Cy7-conjugated CD44 Antibody (IM7) is a Rat-derived and APC-Cy7 conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F060K AF700-conjugated CD44 Antibody (IM7)
AF700-conjugated CD44 Antibody (IM7) is a Rat-derived and AF700 conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P8F060L PC Blue-conjugated CD44 Antibody (IM7)
PC Blue-conjugated CD44 Antibody (IM7) is a Rat-derived and PC Blue conjugated monoclonal antibody, targeting to CD44.

Host: Rat; Reactivity: Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Conjugated Primary Antibodies Primary Antibodies

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HY-P80602A CD44 Antibody (YA801)(PBS only)
CD44 Antibody (YA801) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD44.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P811131 CADM2 Antibody
CADM2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CADM2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P85951 CD56 Antibody (YA5643)
CD56 Antibody (YA5643) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD56.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-K6018 Organoid Anti-Adhesion Rinsing Solution

MCE Organoid Anti-Adhesion Rinsing Solution is specifically formulated to prevent non-specific cell adhesion in cell culture applications.

Cell Biology 3D Cell Culture Organoid Research

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HY-KE8012 Protein Deglycosylation Kit(for O-linked Glycans)

Protein Deglycosylation Kit (for O-linked Glycans)contains O-Glycosidase and a2-3,6,8,9 Neuraminidase.Both enzymes are crucial tool enzymes for glycosylation research and are used in combination to enzymatically release O-linked glycans from glycoproteins.O-Glycosidase is capable of cleaving and releasing Core 1 (Gal-B(1-3)-GalNAc-)and Core 3(GIcNAc-B(1-3)-GalNAc-)O-linked disaccharides,which are linked to the hydroxyl groups of Ser or Thr residues in glycoproteins.a2-3,6,8,9 Neuraminidase can remove a(2,3)-,a(2,6)-,a(2,8)-,and a(2,9)-sialic acid residues from the non-reducing termini of O-linked glycans.

Molecular Biology Restriction Endonuclease

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Keywords

glycosylation | cell adhesion | N-glycans | O-glycans | selectins | integrins | cadherins | CD44 | hyaluronan | cancer metastasis