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Gut Sensory Nerve Endings and the Gut-Brain Axis

Intercellular Communication & Diseases Metabolic Diseases Chronic Inflammation Calcium Homeostasis

Gut sensory nerve endings detect mechanical, chemical, nutritional, microbial, and inflammatory conditions and transmit that information to enteric, spinal, and vagal circuits. The gut-brain axis was once framed mainly as slow endocrine communication, but direct neuroepithelial connections now show that selected epithelial sensor cells can signal with synaptic speed. Enteroendocrine cells extend neuropods toward sensory neurons and contain molecular machinery for neurotransmission, forming a structural route from the intestinal lumen to the nervous system. Research interest is high because these pathways regulate satiation, feeding, nausea, pain, motility, glucose homeostasis, and inflammatory responses, while offering accessible peripheral targets for metabolic and gastrointestinal disease[1].

Distinct epithelial cells and nerve endings encode different signals. Enterochromaffin cells are electrically excitable chemosensors that detect environmental, metabolic, and homeostatic cues and activate serotonin-sensitive primary afferents. Other enteroendocrine neuropod cells form glutamatergic synapses with vagal neurons, transmitting nutrient information from lumen to brainstem within milliseconds. Vagal sensory neurons also display molecularly defined terminal architectures: intestinal mechanoreceptors strongly inhibit hunger-promoting hypothalamic AgRP neurons and reduce feeding, whereas nutrient-responsive mucosal afferents did not produce the same effect in the reported experiments. Mechanosensation, serotonin, glutamate, peptide hormones, and immune mediators therefore operate in parallel rather than through one generic vagal pathway[1][2][3][4].

Disease applications include obesity, diabetes, functional gastrointestinal disorders, nausea, visceral pain, inflammatory bowel disease, and gut-targeted neuromodulation. Therapies could modify epithelial sensing, transmitter release, receptor activation, vagal firing, or central interpretation. Nutrient formulations and drugs may engage specific neuropod or enterochromaffin circuits, while electrical stimulation could alter afferent traffic without directly changing the microbiota. However, an intervention that suppresses feeding may also affect motility, nausea, or glucose regulation, and serotonin-sensitive pathways can signal both normal information and pain. Translational studies must identify the sensory cell, transmitter, nerve subtype, central target, and behavioral output rather than assigning all effects to the “gut-brain axis”[1][2][3][4].

Major gaps include species differences, terminal accessibility, and causal measurement in humans. Mouse genetic labels do not map automatically onto human vagal populations, and organoids lack the complete mechanical, immune, vascular, microbial, and central context. Anatomical work should distinguish mucosal, intraganglionic, muscular, and serosal endings along stomach, small intestine, colon, portal region, and mesentery. Future studies should combine human tissue atlases, spatial imaging of nerve endings, organoid-neuron coculture, electrophysiology, defined luminal challenges, and brainstem imaging. Time-resolved experiments must separate direct neural transmission from later hormonal or immune effects. Microbial metabolites may act first on epithelial or immune cells, so receptor deletion and controlled microbial communities are needed to assign the sensory step. Direct human afferent recordings across centers would provide valuable independent validation. Clinical trials should measure multiple outputs—feeding, symptoms, motility, glucose, autonomic activity, and adverse sensations—to detect pathway tradeoffs. Sampling before and after meals should capture rapid and delayed signals rather than one static biomarker. Precision therapy will require ligand and receptor selectivity at a defined anatomical ending, plus evidence that altered afferent signaling changes disease rather than merely reporting it[1][2][3][4].

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Cat. No. Product Name Information Application Publication
HY-B0407A Chlorpromazine hydrochloride
Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
Dopamine Receptor   Autophagy   Cytochrome P450   5-HT Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
154
HY-12708 Chlorpromazine
Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis.
Dopamine Receptor   Cytochrome P450   Autophagy   5-HT Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
154
HY-A0190 Caerulein
Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.

Source: the skin of a tropical frog

Cholecystokinin Receptor  
Inflammation or Immune System Disease  
148
HY-P1410A GsMTx4 TFA
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
TRP Channel   Piezo Channel  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
136
HY-P1410 GsMTx4
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.
TRP Channel   Piezo Channel  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
136
HY-D0938 CFDA-SE
CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus. CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells.
Fluorescent Dye  
126
HY-18723 Yoda 1
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation.
Piezo Channel   Akt   ERK   Potassium Channel  
Pancreatic Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Lung Fibrosis  
120
HY-L004 Cell Cycle/DNA Damage Compound Library
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair. MCE owns a unique collection of 3,522 cell cycle/DNA damage-related compounds which can be used in the research of the same.

Signaling Pathway Targeting Libraries

93
HY-L003 Apoptosis Compound Library
Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease. MCE designs a unique collection of 3,650 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Signaling Pathway Targeting Libraries

90
HY-L011 Membrane Transporter/Ion Channel Compound Library
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 2,278 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

90
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L086 Neurodegenerative Disease-related Compound Library
Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour. MCE offers a unique collection of 3,759 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

Disease Focused Libraries

85
HY-L013 Neuronal Signaling Compound Library
Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders. MCE designs a unique collection of 3,961 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Signaling Pathway Targeting Libraries

84
HY-L070 Neuroprotective Compound Library
Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases. MCE offers a unique collection of 1,851 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.

Compound Characteristic Classified Libraries

84
HY-L121 5-HT Receptor Compound Library
5-HT receptors, also called Serotonin receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. These receptors are now classified into seven families, 5-HT1–7, comprising a total of 14 structurally and pharmacologically distinct mammalian 5-HT receptor subtypes. The 5-HT receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens. MCE 5-HT Receptor Compound Library consists of 430 5-HT receptor inhibitors and activators, which can be used for neuropsychiatric disorders drugs discovery.

Signaling Pathway Targeting Libraries

84
HY-L047 Endocrinology Compound Library
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function. The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease. MCE offers a unique collection of 908 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Disease Focused Libraries

83
HY-L064 Glutamine Metabolism Compound Library
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 1,827 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Signaling Pathway Targeting Libraries

83
HY-L112 Chemotherapy Drug Library
Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs. Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 156 chemotherapy drugs, which is a useful tool for cancer treatment research.

Disease Focused Libraries

83
HY-L135 Cancer Stem Cells Compound Library
With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on. Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment. MCE supplies a unique collection of 3,540 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

Compound Characteristic Classified Libraries

83
HY-L139 Pain-Related Compound Library
Pain is a kind of distressing feeling caused by the stimulation of tissue damage. According to the International Association for the Study of Pain (IASP), pain is defined as ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Pain is usually classified according to its location, duration, underlying causes, and intensity. For example, acute and chronic pain, muscle pain, and nerve pain. Pain is the main symptom of most diseases, which seriously affects the quality of life and body function of patients. In the medical treatment of pain, anti-inflammatory drugs and opioid analgesic agents have traditionally been used, but the side effects are serious. In recent years, targeted drugs targeting the ERK/MAPK pathway or other targets have gradually become a research hotspot. MCE supplies a unique collection of 3,530 compounds targeting key proteins in the pain system. MCE Pain-Related Compound Library is a useful tool for pain related research and anti-pain drug development.

Disease Focused Libraries

83
HY-L162 Cell Death Library
Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc. MCE designs a unique collection of 3,860 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.

Compound Characteristic Classified Libraries

83
HY-L162M Cell Death Inhibitor Library Mini
Cell death is a core biological process that maintains homeostasis in multicellular organisms, playing a dual role in life activities. On one hand, cell death participates in physiological processes such as cell renewal and damage repair through precise regulation; on the other hand, it actively eliminates damaged, infected, or cancerous cells, thereby blocking pathological progression and preserving organism health. Cell death not only ensures the normal development and growth regulation of organisms but is also closely associated with the occurrence and development of various diseases. Numerous studies have shown that specific types of programmed cell death play critical roles in disease progression, providing an important theoretical basis for developing novel therapeutic strategies by regulating cell death pathways. MCE offers 23 types of commonly used cell death inhibitors, such as apoptosis, ferroptosis, pyroptosis, and cuproptosis, suitable for use as positive controls in the study of novel cell death mechanisms.

Signaling Pathway Targeting Libraries

83
HY-L174 Macrophage Related Compound Library
Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 276 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L201 Cell Proliferation Compound Library
Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others. MCE collects 3,628 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Signaling Pathway Targeting Libraries

83
HY-L202 Flavor Compound Library
Flavor is an expression of smell and taste that is achieved through a variety of chemical processes triggered by molecules. Food flavor is an important attribute of food quality and in some cases determines consumers' food preferences. In addition to playing a key role in taste and smell, flavor molecules can also be involved in regulating metabolism and have an impact on health. In daily life, flavor molecules have absolute application value in food and spices. In scientific research, the study of flavor molecules is helpful to reveal the relationship between food intake and taste perception. Research on the combination behavior of flavor and food components can explore the retention, release and perception of flavor molecules. Most importantly, while exploring multi-sensory flavor perception, the food industry can fully mobilize the enthusiasm of researching new strategies for delicious and healthy food design. Based on the FlavorDB database, collects and organizes 442 flavor molecules, which can be used in taste perception and other related studies.
83
HY-L212 Neuropeptide Library
Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain. MCE can provide 128 neuropeptides that can be used for scientific research.
83
HY-L228 Lipid Metabolite Compound Library
Lipids are important energy storage substances in the human body. They are involved in the regulation of cell structure and function, as well as signaling pathways and gene expression. Abnormal lipid levels in tissues or their dysregulation can lead to various diseases. These include obesity, type 2 diabetes, non-alcoholic fatty liver disease, neurodegenerative diseases, infections, and cancer. Therefore, maintaining normal levels of lipid metabolism is critical to overall health. One of the key features of cancer is aberrant lipid metabolism. This includes alterations in lipid uptake, lipid desaturation, neolipogenesis, lipid droplets, and fatty acid oxidation in cancer cells. These changes all contribute to cellular survival in an ever-changing microenvironment. They do this by modulating feed-forward oncogenic signals and key oncogenic functions. Additionally, they affect oxidative stress, other types of stress, immune responses, and intercellular communication. Alterations in lipid metabolism have a strong impact on the properties of cancer stem cells. This includes aspects such as self-renewal, differentiation, invasion, metastasis, drug sensitivity, and resistance. Furthermore, these alterations also modulate T cell responses. MCE can offer 146 metabolites of lipid metabolism pathways, which can be used for drug screening in cancer, immune-based diseases, metabolic diseases, and other diseases.

Metabolism Focused Libraries

83
HY-L242 Flavors and Fragrances Compound Library
Flavors and fragrances serve as indispensable enhancing elements in modern industries, playing multidimensional roles in the fields of food, cosmetics, and pharmaceutical development. In the food industry, flavors and fragrances are not only used to compensate for flavor loss during processing but also to create novel sensory experiences and enhance product appeal. Natural flavors such as vanilla and citrus oils impart rich, layered aromas to foods, while synthetic flavors can precisely replicate specific tastes, meeting the demands of standardized production and extending the flavor stability of food products. In the cosmetics sector, flavors and fragrances are key to emotional design. They enhance product recognition and elevate the pleasure of use through pleasant scents. In pharmaceutical development, the application of flavors and fragrances focuses on improving compliance. Especially in formulations such as oral liquids and chewable tablets, the addition of mint, fruit, and other flavoring components effectively masks the bitter or irritating taste of medications, increasing patient acceptance. Additionally, some natural flavors may themselves possess auxiliary therapeutic benefits. MCE contains 495 kinds of flavors and fragrances, which can be used in fields such as food, cosmetics and drug development.

Compound Characteristic Classified Libraries

83
HY-L249 Lactylation Compound Library
Protein lactylation, an emerging post-translational modification identified in recent years, plays a critical role in linking cellular metabolic reprogramming, epigenetic regulation, and signaling networks. Based on a systematic framework encompassing lactate metabolism, lactylation, and downstream signaling pathways, this compound library comprehensively targets multiple regulatory layers, including histone modification enzymes (such as p300 and HDACs), key glycolytic enzymes (such as PKM2, LDHA, and GAPDH), transcriptional regulators (such as STAT3, HMGB1, and p53), as well as central signaling pathway nodes including HIF-1α, NF-κB, and PI3K-AKT-mTOR. This integrated design enables a comprehensive representation of the regulatory roles of lactylation across the “metabolism–epigenetics–signaling” axis. MCE has assembled a collection of 6,182 known bioactive compounds and potential functional molecules, making this library suitable for a wide range of applications, including high-throughput drug screening, inhibitor identification, and mechanistic studies. It can be used to systematically evaluate the functional roles of lactylation in biological processes such as tumor metabolism, immune regulation, and inflammatory responses, and to efficiently identify small-molecule candidates with regulatory potential, thereby facilitating the development of innovative therapeutics targeting the interplay between metabolism and epigenetic regulation.

Signaling Pathway Targeting Libraries

83
HY-L264 DNA Damage Repair Inhibitor Library
DNA damage response (DDR) is a fundamental mechanism for maintaining genomic stability. When DNA damage occurs, such as single- or double-strand breaks or replication fork stalling, cells rely on key proteins including ATM, ATR, PARP, and DNA-PK to sense the damage and transmit signals, thereby regulating DNA repair, cell-cycle arrest, and cell death. Inhibition of specific DNA repair or checkpoint pathways can prevent tumor cells from effectively repairing accumulated DNA damage, ultimately leading to tumor cell death. MCE DNA Damage Repair Inhibitor Library contains 1,544 compounds, focusing on key nodes involved in DNA damage response and DNA repair. The library covers multiple DNA repair and cell-cycle checkpoint pathways, providing a systematic compound screening tool for research on precision oncology, synthetic lethality, drug resistance mechanisms, and chemo- or radiosensitization.
83
HY-L923 Ion Channel Lead-like Compound Library
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields. MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Focused and target libraries

83
HY-13443 Exendin-4
Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin‑4 mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin‑4 inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin‑4 reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin‑4 can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease.
GLP Receptor   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Type 2 Diabetes  
72
HY-114118A Semaglutide TFA
Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
GLP Receptor   Apoptosis   Bcl-2 Family   α-synuclein   Autophagy   Insulin Receptor   p38 MAPK  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
50
HY-114118 Semaglutide
Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
GLP Receptor   Apoptosis   Bcl-2 Family   α-synuclein   Autophagy   Insulin Receptor   p38 MAPK  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
50
HY-10095 Olcegepant
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.
CGRP Receptor  
Neurological, Eye or Ear Disease   SARS-CoV-2 Infection  
47
HY-B1473 Serotonin hydrochloride
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist, with blood-brain barrier permeability. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
5-HT Receptor   COMT   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
46
HY-P0264 Exendin(9-39) amide
Exendin (9-39) amide (Avexitide) is a competitive GLP-1R antagonist. Exendin (9-39) amide blocks the Semaglutide (HY-114118)-induced increase in insulin secretion and also attenuates the hypoglycemic effect of Semaglutide. Exendin (9-39) amide abolishes the islet-protective effect of Liraglutide. Exendin (9-39) amide can be used in research on type 2 diabetes and type 1 diabetes.
GLP Receptor  
Type 1 Diabetes   Type 2 Diabetes  
46
HY-B1473A Serotonin
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
5-HT Receptor   COMT   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
46
HY-P0014 Liraglutide
Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.
GCGR   GLP Receptor  
Digestive System Disease   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease   Type 1 Diabetes   Psoriasis   Chronic Obstructive Pulmonary Disease   Type 2 Diabetes   Obesity  
43
HY-19545A SCH-23390 hydrochloride
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
Dopamine Receptor   5-HT Receptor   Potassium Channel  
Depression   Alzheimer's Disease   Obesity  
37
HY-B0282A Acetylcholine bromide
Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.
Biochemical Assay Reagents  
33
HY-N0145 Puerarin
Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which in turn leads to decreased fat absorption.
5-HT Receptor  
Cancer   Inflammation or Immune System Disease   Cardiovascular Disease   Glucose Metabolism   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease  
33
HY-13749 Sitagliptin
Sitagliptin (MK-0431) is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes.
Dipeptidyl Peptidase   ERK   PKA   GLP Receptor  
Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Digestive System Inflammation   SARS-CoV-2 Infection   Obesity  
31
HY-N0737A Harmine
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.
DYRK   5-HT Receptor  
Cancer   Inflammation or Immune System Disease   Alzheimer's Disease   Parkinson's Disease   Obesity  
29
HY-N0455B L-Arginine (L-glutamate)
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research.
Endogenous Metabolite   NO Synthase  
Metabolic or Endocrine Disease  
27
HY-D1421 PKH 67
PKH67 is a fluorescent cell binding dye with green fluorescence. PKH67 can stain the cell membrane and the Ex/Em is 490/502 nm. PKH67 is often used in combination with the non-specific red fluorescent dye PKH26 (Ex/Em=551/567 nm) to label cells, detect cell proliferation in vitro, and trace cells in vitro and in vivo.
Fluorescent Dye  
20
HY-P1097 Gastrin I, human
Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.
Cholecystokinin Receptor  
Metabolic or Endocrine Disease  
18
HY-126010 Dooku1
Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research.
Piezo Channel  
17
HY-14608 L-Glutamic acid
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
Environmental Pollutants   Ferroptosis   iGluR   Endogenous Metabolite   Apoptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
17
HY-14608A L-Glutamic acid monosodium salt
L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors.

Source: mammalian brain

Environmental Pollutants   Ferroptosis   Apoptosis   iGluR   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
16
HY-14541 Olanzapine
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.
5-HT Receptor   Dopamine Receptor   mAChR   Adrenergic Receptor   Autophagy   Mitophagy   Apoptosis  
Cancer   Digestive System Disease   Depression   Digestive System Inflammation   SARS-CoV-2 Infection   Alzheimer's Disease   Parkinson's Disease   Hypertension  
14
HY-14539 Clozapine
Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
Dopamine Receptor   mAChR   Adrenergic Receptor   5-HT Receptor   Ligands for E3 Ligase  
Schizophrenia  
14
HY-106224A Orexin A (human, rat, mouse) TFA
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Orexin Receptor (OX Receptor)  
Neurological, Eye or Ear Disease  
13
HY-106224 Orexin A (human, rat, mouse)
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Orexin Receptor (OX Receptor)  
Neurological, Eye or Ear Disease  
13
HY-15498 Rimegepant
Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine .
CGRP Receptor  
Migraine  
12
HY-P0278A RGD Trifluoroacetate
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.
Integrin  
Cancer  
11
HY-P3212 Allo-aca
Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.
Neuropeptide Y Receptor   Others  
Cancer  
10
HY-P0055 GLP-1(7-37)
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
GLP Receptor  
Metabolic or Endocrine Disease  
10
HY-P1430A 11R-VIVIT TFA
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy.
Nuclear Factor of activated T Cells (NFAT)  
Metabolic or Endocrine Disease  
9
HY-P1430 11R-VIVIT
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy.
Nuclear Factor of activated T Cells (NFAT)  
Metabolic or Endocrine Disease  
9
HY-P0209 Rat CGRP-(8-37)
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
CGRP Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
9
HY-P0203 α-CGRP (mouse, rat)
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.
CGRP Receptor  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
9
HY-19870C Setmelanotide monoacetate
Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.
Melanocortin Receptor   Calmodulin   AMPK  
Blood or Cardio-cerebrovascular Disease   Respiratory Disease   Obesity   Fatty Liver Disease  
8
HY-110066 (Z)-Guggulsterone
(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection.
Apoptosis   VEGFR   Akt   Angiotensin-converting Enzyme (ACE)   SARS-CoV   FXR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Pain   Digestive System Inflammation   Hypertension   Obesity   Lung Fibrosis  
8
HY-B1811 Vasopressin
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
7
HY-P1410C D-GsMTx4 TFA
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis.
Piezo Channel   Calcium Channel   mTOR   PI3K   Akt  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
6
HY-106301 Devazepide
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.
Cholecystokinin Receptor  
Metabolic or Endocrine Disease  
6
HY-N0816 Polyphyllin VI
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer.
Apoptosis   Pyroptosis  
Digestive System Disease   Lung Cancer   Depression   Digestive System Inflammation  
6
HY-P1410B D-GsMTx4
D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 inhibits [Ca2+]i elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis.
Piezo Channel   Calcium Channel   mTOR   PI3K   Akt  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
6
HY-P1071 α-CGRP (human)
α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects.
CGRP Receptor  
Hypertension  
6
HY-P80920 TREM2 Antibody
TREM2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TREM2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

6
HY-B1661 Hexamethonium chloride
Hexamethonium Chloride Dihydrate is a synthetic organic compound commonly used as a ganglion blocking agent, which means it blocks the transmission of nerve impulses between ganglion cells in the autonomic nervous system. Hexamethonium Chloride Dihydrate is used in various medical applications such as lowering blood pressure or inhibiting certain types of neuropathic pain. It works by inhibiting the release of acetylcholine, a neurotransmitter that plays a key role in regulating many bodily functions.
Biochemical Assay Reagents  
Blood or Cardio-cerebrovascular Disease  
5
HY-P73316 Beta-NGF Protein, Human (CHO)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (CHO) is produced by CHO cells (S122-R239), with tag free.

Species: Human; Source: CHO

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

5
HY-N6779 Patulin
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.

Source: Penicillium and Aspergillus

Bacterial   Apoptosis   Autophagy   Antibiotic  
Digestive System Disease   Bacterial Infection   Digestive System Inflammation  
4
HY-P1471 Adrenomedullin (AM) (22-52), human
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.
CGRP Receptor  
Blood or Cardio-cerebrovascular Disease  
4
HY-107725 BIBO3304
BIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
Neuropeptide Y Receptor  
Obesity  
4
HY-P0093 Sincalide
Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK.
Cholecystokinin Receptor   Apoptosis   PI3K   Akt  
Cancer   SARS-CoV-2 Infection  
4
HY-P702778 beta-NGF Protein, Rat (HEK293, His)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss.

Species: Rat; Source: HEK293

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

4
HY-W247131 DASPEI
DASPEI is a cationic styrenyl mitochondrial dye with large Stokes shift. DASPEI has excitation and emission wavelength at 550/573 nm, which has good light chromogenic property. DASPEI can stain mitochondria in living cells with good labeling property. And DASPEI can also be used to stain presynaptic nerve endings independently of neuronal activity.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
3
HY-P0198A Neuropeptide Y (human,rat,mouse) TFA
Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
3
HY-P0198 Neuropeptide Y (human,rat,mouse)
Neuropeptide Y (human,rat,mouse) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
Neuropeptide Y Receptor  
Metabolic or Endocrine Disease   Alzheimer's Disease  
3
HY-D0970 Diphenyl Blue
Diphenyl Blue (Trypan Blue) is a cell active dye, the most commonly used dye for the identification of dead cells, of en used to test cell membrane integrity and cell viability. Diphenyl Blue staining is one of the methods for tissue and cell culture. When cells are deactivated or have incomplete cell membranes, Diphenyl Blue can stain them Blue. Normal living cells with intact cell membranes reject Diphenyl blue and do not stain them blue. However, macrophages are capable of phagocytosis of Diphenyl Blue, so it can be used as a living stain for macrophages.
Fluorescent Dye  
3
HY-P3462A Cagrilintide acetate
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.
CGRP Receptor  
Metabolic or Endocrine Disease  
3
HY-P0090 Calcitonin (salmon)
Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
CGRP Receptor  
Cancer  
3
HY-P3462 Cagrilintide
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.
CGRP Receptor  
Metabolic or Endocrine Disease  
3
HY-P3506 Retatrutide
Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity.
GCGR   GLP Receptor  
Obesity  
3
HY-K0353 Human CD3/CD28 T Cell Activation Magnetic Beads

MCE Human CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

Cell Biology Cell Isolation

3
HY-P3419A PAMP-12 (unmodified) TFA
PAMP-12 (unmodified) TFA is an endogenous peptide and is a MrgX2 agonist. PAMP-12 (unmodified) TFA can reduce cAMP accumulation, increase Ca2+ levels, enhance beta-arrestin recruitment, decrease IP-1, and increases phosphoERK. PAMP-12 (unmodified) TFA can elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. PAMP-12 (unmodified) TFA can be used for the research of hypotension and ulcerative colitis.
Mas-related G-protein-coupled Receptor (MRGPR)   PERK   Calcium Channel  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
2
HY-P2537 Apelin-12
Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.
HIV   Apelin Receptor (APJ)  
Neurological, Eye or Ear Disease   Viral Infection  
2
HY-N1374 Magnolin
Magnolin, a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
ERK  
Inflammation or Immune System Disease   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Pain   Obesity   Lung Fibrosis  
2
HY-P2932 Cholecystokinin
Cholecystokinin is a peptide hormone. Cholecystokinin, as a hunger suppressant, inhibits food intake and stimulates the digestion of fat and protein. Cholecystokinin can be used for the research of gastrointestinal system.
Cholecystokinin Receptor  
Metabolic or Endocrine Disease  
2
HY-P99463 Batiraxcept
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((KD <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis.
TAM Receptor   PI3K   Akt   p38 MAPK  
Cancer  
2
HY-P1848 Pep-1 (uncapped)
Pep-1 (uncapped) is a specific ligand of IL-13Ra2. Pep-1 (uncapped) exerts cell penetrating activity through receptor-mediated endocytosis, can cross the blood-tumor barrier (BTB) and target glioma cells. Pep-1 (uncapped) can enhance the uptake of nanoparticles by tumor cells and enhance the cell penetration ability of nanoparticles, and can be used to develop targeted drug delivery systems for glioma.
Interleukin Related  
Cancer  
2
HY-B0025 Voglibose
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

Source: Streptomyces hygroscopicies var. limonons.

Glycosidase  
Colorectal Cancer   Glucose Metabolism   SARS-CoV-2 Infection   Parkinson's Disease  
2
HY-106840 L-365260
L-365260 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance.
Cholecystokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
2
HY-P99051 Tinurilimab
Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system.

Species: Human

Transmembrane Glycoprotein  
Cancer   Inflammation or Immune System Disease  
2
HY-131018 Jedi2
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM.
Piezo Channel  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
2
HY-P3419 PAMP-12 (unmodified)
PAMP-12 (unmodified) is an endogenous peptide and is a MrgX2 agonist. PAMP-12 (unmodified) can reduce cAMP accumulation, increase Ca2+ levels, enhance beta-arrestin recruitment, decrease IP-1, and increases phosphoERK. PAMP-12 (unmodified) can elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. PAMP-12 (unmodified) can be used for the research of hypotension and ulcerative colitis.
Mas-related G-protein-coupled Receptor (MRGPR)   PERK   Calcium Channel  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
2
HY-101986 BIIE-0246
BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
Neuropeptide Y Receptor  
Glucose Metabolism   Obesity  
2
HY-P99011 Cibisatamab
Cibisatamab, a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab can be used for colorectal cancer research.

Species: Human

CD3  
Colorectal Cancer  
2
HY-W014666 Xanthurenic acid
Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
Endogenous Metabolite   mGluR   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation  
2
HY-N0122 5-Hydroxytryptophan
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .
Endogenous Metabolite   5-HT Receptor  
Glucose Metabolism   Alzheimer's Disease   Obesity  
2
HY-P73317 Beta-NGF Protein, Mouse (CHO)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (CHO) is produced by CHO cells (S122-G241), with tag free.

Species: Mouse; Source: CHO

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

2
HY-K0310 Mouse CD8+ Cell Positive Selection Kit

MCE Mouse CD8+ Cells Positive Selection Kit is designed for the isolation of CD8+ cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

Cell Biology Cell Isolation

2
HY-113308AS Taurolithocholic acid-d4 sodium
Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
1
HY-W016145S L-Glutamic acid-13C5 hydrate salt
L-Glutamic acid-13C5 hydrate salt is the 13C labeled L-Glutamic acid hydrate salt. L-Glutamic acid monosodium hydrate is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium hydrate has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium hydrate can be used in the study of neurological diseases. L-Glutamic acid monosodium hydrate acts at ionotropic and?metabotropic glutamate receptors.
Isotope-Labeled Compounds   Endogenous Metabolite   iGluR   Ferroptosis   Apoptosis  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
1
HY-D0994A 4-Methylumbelliferyl phosphate disodium
4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant.
Phosphatase  
1
HY-P3641 Kisspeptin 13
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
GnRH Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-W040074 Glycylglycine hydrochloride hydrate
Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
1
HY-A0022 Azaphen
Azaphen (Azafen) is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen can be used in studies related to depression.

Source: from the cadaveric material

Serotonin Transporter   5-HT Receptor  
Depression  
1
HY-P0285 Rabies Virus Glycoprotein
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

Source: Rabies Virus Glycoprotein

RABV  
Infection  
1
HY-B1173 (+)-Camphor
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation.
Environmental Pollutants   Bacterial  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Breast Cancer   Leukemia/Lymphoma/Myeloma   Bacterial Infection  
1
HY-P5982 PTPσ Inhibitor, ISP
PTPσ Inhibitor, ISP is a PTPσ intracellular wedge domain mimetic peptide containing a TAT cell-penetrating domain, which acts as a PTPσ inhibitor. PTPσ Inhibitor, ISP binds to and inhibits PTPσ, thereby relieving CSPG-mediated axonal growth inhibition. PTPσ Inhibitor, ISP enhances CSPG degradation by promoting the secretion of Cathepsin B or MMP-2, and promotes DRG axonal growth, OPC migration and remyelination. PTPσ Inhibitor, ISP promotes nerve regeneration and improves sensory, motor and urinary functions in animal models of spinal cord injury, dorsal root injury and multiple sclerosis. PTPσ Inhibitor, ISP also increases the phosphorylation of ERK and AKT in colorectal cancer cells. PTPσ Inhibitor, ISP can be used in studies related to PTPσ/CSPG signaling, nerve regeneration, demyelinating diseases and RAS/ERK signaling.
Phosphatase   Transmembrane Glycoprotein   MMP   ERK   Akt   Cathepsin  
Neurological, Eye or Ear Disease   Colorectal Cancer  
1
HY-P3641A Kisspeptin 13 TFA
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
GnRH Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-100894 Biotin-VAD-FMK
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.
Caspase  
Cancer  
1
HY-Z0478 (-)-Limonene
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture.
Bacterial   Antibiotic   CaMK  
Metabolic or Endocrine Disease   Bacterial Infection   Cardiovascular Disease   Parkinson's Disease  
1
HY-125556 Tetragastrin
Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist. Gastric mucosal protection.
Cholecystokinin Receptor  
Obesity  
1
HY-P2543 Neuropeptide Y (3-36) (human, rat)
Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides[1].
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
1
HY-126437H Poly-L-lysine hydrobromide (MW 4000-15000)
Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery.
Biochemical Assay Reagents  
1
HY-P99419 Acasunlimab
Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer.

Species: Human

PD-1/PD-L1  
Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer  
1
HY-B1473S Serotonin-d4 hydrochloride
Serotonin-d4 (5-Hydroxytryptamine-d4) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473). Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Isotope-Labeled Compounds   COMT   Endogenous Metabolite   5-HT Receptor  
1
HY-P990001 Anti-Mouse IL-10 Antibody (JES5-2A5)
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for researches on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM).

Species: Mouse

Interleukin Related  
Cancer   Metabolic or Endocrine Disease   Neurodegenerative Disease   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
1
HY-14450 JNJ-31020028
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Obesity  
1
HY-P1127 Galanin (1-30), human
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-D0994 4-Methylumbelliferyl phosphate
4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate is also a nerve agent simulant.
Phosphatase  
1
HY-107726 BIBP3226 TFA
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
1
HY-162501 Yaddle1
Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants.
Piezo Channel  
Inflammation or Immune System Disease  
1
HY-18569B 3-Indoleacetic acid,suitable for plant cell culture
3-Indoleacetic acid, suitable for plant cell culture (IAA), is a naturally occurring plant growth hormone that is widely present in plants, bacteria, and fungi. 3-Indoleacetic acid, suitable for plant cell culture, is a plant growth-promoting hormone that not only promotes plant growth but also protects bacteria from the toxic damage to cell membrane potential caused by other indole intermediate products (such as I3P) produced during their own metabolic processes. 3-Indoleacetic acid, suitable for plant cell culture, can be used in plant cell culture.
Endogenous Metabolite  
Bacterial Infection  
1
HY-Y1147 Diethyl maleate
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].
Biochemical Assay Reagents  
1
HY-W250122 Glutamic acid sodium salt
Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders.
Biochemical Assay Reagents   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Apoptosis   HSP   Bcl-2 Family  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
1
HY-Y0367 Maleic acid
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
Environmental Pollutants   Bacterial   Endogenous Metabolite  
Bacterial Infection  
1
HY-14608R L-Glutamic acid (Standard)
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. IC50 & Target:DA. In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus.
L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma.
In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice.
L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats.
Reference Standards   Endogenous Metabolite   iGluR   Ferroptosis   Apoptosis  
Neurological, Eye or Ear Disease  
1
HY-B1473AS Serotonin-d4
Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Isotope-Labeled Compounds   5-HT Receptor   COMT   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
1
HY-P99144A Anti-Mouse PD-1 Antibody (S-5001)
Anti-Mouse PD-1 Antibody (S-5001) is a selective inhibitor targeting PD-1, blocking the PD-1/PD-L1 immune checkpoint axis through competitive binding to PD-1. Anti-Mouse PD-1 Antibody (S-5001) works by reversing the tumor immunosuppressive microenvironment and reactivating the anti-tumor activity of cytotoxic T lymphocytes. It can be used in research on tumors such as melanoma and HPV-positive oropharyngeal squamous cell carcinoma. Anti-Mouse PD-1 Antibody (S-5001) is often combined with photothermal therapy, chemotherapy, etc., to enhance efficacy.

Species: Mouse

PD-1/PD-L1  
Cancer Immunology   Immunotherapy for Melanoma   Squamous Cell Carcinoma  
1
HY-A0261 Pentagastrin
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCKB) receptor agonist with an EC50 value of 11 nM. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury.
Cholecystokinin Receptor  
Cancer   Metabolic or Endocrine Disease  
1
HY-W015273A trans-3-Indoleacrylic acid
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis
Endogenous Metabolite   Ferroptosis  
Metabolic or Endocrine Disease   Colorectal Cancer  
1
HY-170230 Bovine Endothelial cell growth supplement,suitable for cell culture
Bovine Endothelial cell growth supplement, suitable for cell culture (ECGS, Bovine) is a culture medium supplement, endothelial cell growth supplement (ECGS), which promotes the proliferation of human saphenous vein endothelial cells (HSVEC) and human umbilical vein endothelial cells (HUVEC).
Biochemical Assay Reagents  
1
HY-DY3003 Tissue and Cell Fixative (4% Paraformaldehyde, PFA)
Tissue and Cell Fixative (4% Paraformaldehyde, PFA) is mainly composed of paraformaldehyde, phosphate, and deionized water, with a pH of 7.0-7.4. Tissue and Cell Fixative (4% Paraformaldehyde, PFA) is suitable for fixing most tissues and cells, and can effectively protect the morphology and structure of tissues and cells as well as nucleic acids.
Biochemical Assay Reagents  
1
HY-P2671 [Leu15]-Gastrin I (human)
[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer.
Cholecystokinin Receptor  
Cancer  
1
HY-P99024 Glofitamab
Glofitamab (RO7082859) is a T-cell-engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab leads to T-cell activation, proliferation, and tumor cell killing upon binding to CD20 on malignant cells. Glofitamab induces durable complete remissions in relapsed or refractory B-Cell non-Hodgkin lymphoma (B-NHL).

Species: Human

CD20   CD3  
Cancer   Inflammation or Immune System Disease  
1
HY-K0306 Mouse CD3+ T Cells Negative Selection Kit

MCE Mouse CD3+ T Cells Negative Selection Kit is designed for the isolation of CD3+ T cells from single cell suspensions of mouse spleen cells and lymph nodes.

Cell Biology Cell Isolation

1
HY-K0307 Mouse CD4+ T Cells Negative Selection Kit

MCE Mouse CD4+ T Cells Negative Selection Kit is designed for the isolation of CD4+ T cells from single cell suspensions of mouse spleen cells and lymph nodes.

Cell Biology Cell Isolation

1
HY-P11700 AAPDARETA
AAPDARETA is a mutated MHC-associated peptide with reduced binding affinity to H-2Db MHC molecules. AAPDARETA activates subsets of mouse main olfactory epithelium sensory neurons and induces Ca2+ transients.
MHC  
Inflammation or Immune System Disease  
/
HY-109077S Tigolaner-d4
Tigolaner-d4 is deuterium labeled Tigolaner. Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.
Isotope-Labeled Compounds   GABA Receptor   Parasite   Chloride Channel  
Infection   Neurological, Eye or Ear Disease  
/
HY-114558S Resmethrin-d5
Resmethrin-d5 (Benzofuroline-d5) is the deuterium labeled Resmethrin (HY-114558). Resmethrin (Benzofuroline) is a reproductively toxic compound that inhibits spermatogenesis and induces apoptosis of germ cells in mouse testis culture in vitro, but has no significant toxicity to supporting cells and interstitial cells.
Isotope-Labeled Compounds   Environmental Pollutants   Insecticide  
/
HY-B1473S2 Serotonin-13C,D4
Serotonin-13C,D4 (5-Hydroxytryptamine-13C,D4) is a 13C- and deuterated labeled Serotonin (HY-B1473A). Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Isotope-Labeled Compounds   Endogenous Metabolite   COMT   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-14608AR L-Glutamic acid monosodium salt (Standard)
L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases.
Reference Standards   iGluR   Apoptosis   Ferroptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-P10690 CCHa1 peptide
CCHa1 peptide is a signaling peptide that plays a role in inhibiting sleep arousal. It is produced by enteroendocrine cells in the gut and modulates the animal's response to sensory inputs such as mechanical vibrations by acting on specific dopamine neurons in the brain, thereby helping to suppress arousal responses. CCHa1 peptide holds potential for research in fields related to sleep quality and sensory adaptation.
Others  
Neurological, Eye or Ear Disease  
/
HY-131384 8,11,14-Eicosatriynoic acid
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
COX  
/
HY-P990248 Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) is an anti-mouse E-Cadherin/CD324 IgG1 monoclonal antibody. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can downregulate the HER signaling axis and PI3K/Akt/mTOR signaling pathway. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can inhibit the proliferation of tumor cells and induce their apoptosis. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can be used for researches on cancer and inflammation conditions such as breast cancer, chronic compression injury (CCI) and asthma.

Species: Mouse

Cadherin   EGFR   PERK   Akt   mTOR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Breast Cancer  
/
HY-136820S1 Taurultam-d2 hydrochloride
Taurultam-d2 hydrochloride is the d2-labeled Taurultam (HY-136820) hydrochloride. Taurultam is the major active hydrolytic metabolite of Taurolidine (HY-W011522), which selectively activates hTRPA1 to trigger effects in sensory neurons. Taurultam exhibits activity against SARS-CoV-2 variants, influenza A viruses (H1N1, H3N2) and influenza B viruses. Taurultam induces mild tracheal sensory nerve stimulation and CGRP release in mice. Taurultam can be used in studies related to SARS-CoV-2 infection, influenza virus infection, and co-infection with SARS-CoV-2 and influenza A virus.
Isotope-Labeled Compounds   Drug Metabolite   TRP Channel   SARS-CoV   Influenza Virus  
Viral Infection  
/
HY-N12760 Lobophorin CR-2
Lobophorin CR-2 is a lobophorin congener which induces UPR-associated gene expression, inhibits oral squamous cell carcinoma cell growth, and causes UPR-dependent cell death in MEF cells.

Source: marine microorganisms

Others  
/
HY-138794G XL177A (GMP)
XL177A GMP is XL177A (HY-138794) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections.
Deubiquitinase   SARS-CoV   Histone Demethylase  
/
HY-172166B TRITC-lysine-dextran (MW 70kDa)
TRITC-lysine-dextran (MW 70kDa) is a fluorescent label prepared by the conjugation of TRITC (HY-D0791), lysine and dextran. TRITC-lysine-dextran (MW 70kDa) serves multiple functions as an axonal tracer, non-viral nanocarrier and fixable fluorescent clonal marker. TRITC-lysine-dextran (MW 70kDa) undergoes anterograde and retrograde transport within axons of sensory neurons, and acts as a non-viral delivery system to precisely deliver biomolecules to neurons. TRITC-lysine-dextran (MW 70kDa) remains stably retained during histological preparation, thereby supporting continuous observation in live or fixed samples.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-130921 Sulfo-Cyanine7 carboxylic acid potassium
Sulfo-Cyanine7 carboxylic acid potassium is a near-infrared fluorescent dye. Sulfo-Cyanine7 carboxylic acid potassium is applicable to ex vivo histological imaging of the trigeminal nerve in rats as well as studies on the distribution and retention in brain tissues. Sulfo-Cyanine7 carboxylic acid potassium can serve as a model hydrophilic probe for multiplex biomedical fluorescence imaging (Ex=750 nm, Em=773 nm).
Fluorescent Dye  
/
HY-P3539 Exendin-4 (3-39)
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.
GCGR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-126169 L-Glutamine amide
L-Glutamine amide is a metabolite involved in glutamate metabolism.
Endogenous Metabolite  
Infection  
/
HY-D1367 Sulfo-Cyanine7 carboxylic acid
Sulfo-Cyanine7 carboxylic acid is a near-infrared fluorescent dye. Sulfo-Cyanine7 carboxylic acid is applicable to ex vivo histological imaging of the trigeminal nerve in rats as well as studies on the distribution and retention in brain tissues. Sulfo-Cyanine7 carboxylic acid can serve as a model hydrophilic probe for multiplex biomedical fluorescence imaging (Ex=750 nm, Em=773 nm).
Fluorescent Dye  
/
HY-124410S Mitoquinol-d15
Mitoquinol-d15 is deuterium labeled Mitoquinol (HY-124410). Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs.
Isotope-Labeled Compounds   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-149448 Poly-γ-benzyl-L-glutamate (MW 150000-350000)
Poly-γ-benzyl-L-glutamate (MW 150000-350000) is aamino acid polymer.
Amino Acid Derivatives  
/
HY-16974S Afoxolaner-d6
Afoxolaner-d6 is the deuterium labeled Afoxolaner (HY-16974). Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
Isotope-Labeled Compounds   Parasite   Chloride Channel   GABA Receptor  
Infection  
/
HY-180635 N-Succinyl-L-glutamate 5-semialdehyde
N-Succinyl-L-glutamate 5-semialdehyde is a metabolite in the glutamate metabolic pathway.
Endogenous Metabolite  
/
HY-N0390G L-Glutamine (GMP)
L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
mTOR   NF-κB   STAT   HIF/HIF Prolyl-Hydroxylase  
Inflammation or Immune System Disease   Ischemic Stroke   Osteoporosis   Osteoarthritis  
/
HY-14794S Dextromilnacipran-d6
Dextromilnacipran-d6 is the deuterium labeled Dextromilnacipran (HY-14794). Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia.
Isotope-Labeled Compounds   Serotonin Transporter   Adrenergic Receptor  
Metabolic or Endocrine Disease  
/
HY-109841S Oleoyl Serotonin-d17
Oleoyl Serotonin-d17 is the deuterium labeled Oleoyl Serotonin.
TRP Channel   Isotope-Labeled Compounds  
/
HY-B2046S Simazine-d10
Simazine-d10 is the deuterium labeled Simazine (HY-B2046). Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.
Isotope-Labeled Compounds   Herbicide   Apoptosis   Reactive Oxygen Species (ROS)   Bcl-2 Family   Caspase  
Inflammation or Immune System Disease  
/
HY-100821 2,4-Dihydroxyphenylacetylasparagine
2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes.

Source: Nephila clavata

Bacterial  
Infection  
/
HY-P992377 HY-0102
HY-0102 is a humanized IgG anti-NKG2A monoclonal antibody and immune checkpoint inhibitor targeting the NKG2A/HLA-E axis. HY-0102 is applicable for the research of advanced solid tumors.

Species: Human

C-type Lectin-like Receptors (CTLRs)  
Cancer  
/
HY-B0356G Ciprofloxacin (GMP)
Ciprofloxacin GMP is Ciprofloxacin (HY-B0356) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Ciprofloxacin (Bay-09867) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity.
Bacterial   Topoisomerase   Akt   β-catenin  
Digestive System Disease   Periodontal Disease  
/
HY-P5065 Galanin-Like Peptide (rat)
Galanin-Like Peptide (rat) is a 60 amino acid neuropeptide. Galanin-Like Peptide (rat) plays an important role in the regulation of feeding, body weight and energy metabolism.
Neuropeptide Y Receptor  
Metabolic or Endocrine Disease  
/
HY-W480392 1,9-Dimethylxanthine
1,9-Dimethylxanthine is an adenosine receptor antagonist that has the activity of blocking the effects of adenosine on the central nervous system. 1,9-Dimethylxanthine enhances nerve excitability by regulating the adenosine system. 1,9-Dimethylxanthine is used as a pharmacological tool in research to help explore physiological and pathological processes related to adenosine.
Adenosine Receptor  
/
HY-P1134 Galanin (1-15) (porcine, rat)
Galanin (1-15) (porcine, rat) is the N-terminal 15 amino acids peptide fragment of the neuropeptide galanin. Galanin (1-15) (porcine, rat) interacts with the 5-HT1A receptor in the dorsal hippocampus of the rat brain, reduces the affinity of 5-HT1A receptors, and regulates the serotonin neuronal networks.
5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-106224AS Orexin A-13C6,15N (human, rat, mouse) TFA
Orexin A-13C6,15N (human, rat, mouse) (Hypocretin-1-13C6,15N (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Isotope-Labeled Compounds   Orexin Receptor (OX Receptor)  
/
HY-W141786 Magnesium L-glutamate
Magnesium L-glutamate is a cysteine derivative. Magnesium L-glutamate s a flavor enhancer used to reduce the amount of salt needed in meat products.
Amino Acid Derivatives  
/
HY-A0144AR Etilefrine hydrochloride (Standard)
Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output.
Reference Standards   AMPK   Adrenergic Receptor   Akt  
Blood or Cardio-cerebrovascular Disease  
/
HY-149773S HPK1-IN-40-d2
HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity.
MAP4K  
Cancer   Inflammation or Immune System Disease  
/
HY-N0059S1 D-Arabinose-13C-1
D-Arabinose-13C-1 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).
Isotope-Labeled Compounds   Parasite   Bacterial   AMPK   PPAR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-144201S Serotonin glucuronide-d4
Serotonin glucuronide-d4 is the deuterium labeled Serotonin glucuronide.
Isotope-Labeled Compounds  
/
HY-P992366 HFB200901
HFB200901 is a galectin LGALS9 inhibitor and immunostimulant that can be used in studies related to pancreatic adenocarcinoma, pancreatic intraepithelial neoplasia, KRASG12C-mutant colon cancer, and prostate cancer. HFB200901 disrupts the LGALS9/TIM-3 axis, while blocking the internalization and vacuolization of recombinant LGALS9. HFB200901 reduces the proportion of regulatory T cells (Treg) and enhances dendritic cell activation, thereby inducing polyfunctional and memory CD8+ T cell responses. HFB200901 inhibits the progression of pancreatic neoplastic lesions and effectively improves the efficacy of PSMA-based vaccination.

Species: Human

Galectin   Tim3  
Prostate Cancer  
/
HY-N10272 (±)-Avenaciolide
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation.

Source: Aspergillus avenaceaus

Fungal   Bacterial  
Bacterial Infection  
/
HY-P11701 SEIDLILGY
SEIDLILGY is a nonapeptide identified as a peptide ligand derived from mouse major histocompatibility complex class I (MHC). SEIDLILGY serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the particular vomeronasal receptor (V2rf2).
MHC  
/
HY-113308AS2 Taurolithocholic acid-d4-1 sodium
Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
/
HY-B0383AS2 Almotriptan-d3 benzoate
Almotriptan-d3 benzoate (PNU180638 free base-d3) is deuterated labeled Almotriptan benzoate. Almotriptan benzoate is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan benzoate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan benzoate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan benzoate can be used in research related to migraine.
Isotope-Labeled Compounds   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-W698686 β-Galactosyl-C18-ceramide
β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.
Biochemical Assay Reagents  
/
HY-180687 N-Formyl-L-glutamate
N-Formyl-L-glutamate (N-Formyl-L-glutamic acid) can be obtained from the conversion of L-histidine. N-Formyl-L-glutamate can be degraded into L-glutamate.
Nucleoside Antimetabolite/Analog  
/
HY-D0919 NIR-Red Dead Cell-3 Dye
NIR-Red Dead Cell-3 Dye is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
Fluorescent Dye  
/
HY-P991800 Anti-Mouse Dendritic Cells Antibody (33D1)
Anti-Mouse Dendritic Cells Antibody (33D1) reacts with the mouse dendritic cells. Dendritic cells (DC) are a small subpopulation of lymphoid cells with distinctive cytologic features, surface properties, and functions. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).

Species: Mouse

Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-17372S Rofecoxib-d5
Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
Isotope-Labeled Compounds   COX  
Cancer   Inflammation or Immune System Disease  
/
HY-113308S Taurolithocholic acid-d5
Taurolithocholic acid-d5 is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
/
HY-B1430S Butamben-d9
Butamben-d9 is the deuterium labeled Butamben. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions.
Isotope-Labeled Compounds   Calcium Channel   Sodium Channel   Potassium Channel  
Neurological, Eye or Ear Disease  
/
HY-D3171 AD-BChE/HClO
AD-BChE/HClO is a dual-target two-photon fluorescent probe. AD-BChE/HClO produces strong fluorescence only in the simultaneous presence of BChE and HClO. AD-BChE/HClO enables two-photon imaging in nerve cells and mouse brain tissues via tail vein injection. AD-BChE/HClO can be used for the research of Alzheimer's disease (Ex/Em = 450 nm/500 nm).
Fluorescent Dye   Cholinesterase (ChE)  
Alzheimer's Disease  
/
HY-115402 DAz-1
DAz-1 is a sulfonic acid probe for living cells, which can directly detect sulfonic acid-modified proteins in living cells and is cell-permeable.
Fluorescent Dye  
/
HY-P4610 H-Trp-Tyr-OH
H-Trp-Tyr-OH is an orally active tryptophan-tyrosine dipeptide with blood-brain barrier permeability. H-Trp-Tyr-OH exerts physiological regulatory effects by stimulating enteroendocrine cells to secrete glucagon-like peptide GLP-1. In mouse models of tauopathies, H-Trp-Tyr-OH inhibits tau phosphorylation, reduces the level of neurofibrillary tangles, increases dopamine turnover, upregulates synapsin expression, and elevates cecal short-chain fatty acid levels, thereby improving behavioral deficits and extending lifespan. H-Trp-Tyr-OH can be used in research related to impaired glucose tolerance and tauopathies.
GLP Receptor  
Glucose Metabolism  
/
HY-B0383AS Almotriptan hydrochloride-d6
Almotriptan-d6 (PNU180638-d6) hydrochloride is the deuterium labeled Almotriptan hydrochloride. Almotriptan hydrochloride is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan hydrochloride shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan hydrochloride induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan hydrochloride can be used in research related to migraine.
Isotope-Labeled Compounds   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-N6779S Patulin-13C7
Patulin-13C7 (Terinin-13C7) is the 13C labeled Patulin (HY-N6779). Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.
Isotope-Labeled Compounds  
Infection  
/
HY-P5163 NMB-1
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC50: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain.
Others  
Inflammation or Immune System Disease  
/
HY-D3189 5GluAF-2MeTG
5GluAF-2MeTG is an activatable fluorescent probe targeting the glutamate carboxypeptidase (CP) activity of PSMA (Ex/Em=490/500-600 nm). After being hydrolyzed by PSMA, 5GluAF-2MeTG releases a cell membrane-permeable fluorescent product, and achieves fluorescence activation by disrupting donor-excited photoinduced electron transfer (d-PeT). 5GluAF-2MeTG enables fluorescence imaging of live PSMA-expressing prostate cancer cells in vitro and visualizes the carboxypeptidase activity of PSMA. 5GluAF-2MeTG can be used to detect prostate cancer regions in preclinical excised tissue specimens.
Fluorescent Dye   PSMA  
/
HY-W779386 N-Acetylglycine-13C2,15N
N-Acetylglycine-13C2,15N (Aceturic acid-13C2,15N) is the 13C- and 15N-labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods. N-Acetylglycine is a flavor enhancer which elicits Monosodium glutamate (MSG)-like sensory experiencesN-Acetylglycine.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-P10287 Neuropeptide W-30 (human)
Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human) activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-D3172 BD-105
BD-105 (Glucagon Yellow) is a glucagon-binding fluorescent probe with a KD value of 13.3 μM. BD-105 exhibits changes in fluorescence intensity upon interaction with glucagon, and colocalizes with glucagon in cells and tissues. BD-105 is a selective cell stain that labels glucagon-secreting cells without staining insulin-secreting cells or non-endocrine control cells. BD-105 serves as an imaging reagent for glucagon in live cells and tissues (Ex/Em = 540 nm/580 nm).
Fluorescent Dye  
Metabolic or Endocrine Disease  
/
HY-W745139 5-Octyl D-Glutamate
5-Octyl D-Glutamate is aamino acids and their derivatives.
Amino Acid Derivatives  
/
HY-P11702 f-MFFINTLTL
f-MFFINTLTL is a formylated nonapeptide and a natural ligand from mitochondria or bacteria. f-MFFINTLTL serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the specific vomeronasal receptor (V2rf2).
Bacterial  
/
HY-W037817 Dimethyl L-glutamate
Dimethyl L-glutamate (Dimethyl glutamate) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate can be used in research related to bone defects and non-insulin-dependent diabetes mellitus.
iGluR   Phosphatase  
Metabolic or Endocrine Disease   Musculoskeletal and Skin Disease  
/
HY-P5063 Galanin-Like Peptide (human)
Galanin-Like Peptide (human) is a 60 amino acid neuropeptide. Galanin-Like Peptide (human) plays an important role in the regulation of feeding, body weight and energy metabolism.
Neuropeptide Y Receptor  
Metabolic or Endocrine Disease  
/
HY-W724404 N-Oleoyl serinol-d5
N-Oleoyl serinol-d5 (Oleoyl serinol-d5) is the deuterium labeled N-Oleoyl serinol (HY-122788). N-Oleoyl serinol is a ceramide analog that can be used in stem cell therapy to prevent stem cells from developing into teratomas. N-Oleoyl serinol induces apoptosis in residual pluripotent embryoid body-derived cells (EBCs), prevents teratoma formation, and enriches EBC cells that undergo neural differentiation after transplantation.
Isotope-Labeled Compounds   Apoptosis  
Cancer  
/
HY-143797S Almotriptan-d6 maleate
Almotriptan-d6 (PNU180638-d6) maleate is the deuterium labeled Almotriptan maleate. Almotriptan malate is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan malate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan malate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan malate can be used in research related to migraine.
Isotope-Labeled Compounds   5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-B0158S4 Cytidine-d1
Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol
Isotope-Labeled Compounds   Endogenous Metabolite   Nucleoside Antimetabolite/Analog  
Neurological, Eye or Ear Disease  
/
HY-103279 BIM187
BIM187 is a Bombesin Receptor agonist that induces satiety. BIM187 significantly reduces short-term food intake in rats, but does not alter the total 6 h food intake of rats. BIM187 can be used in studies related to feeding behavior and satiety regulation in rats.
Bombesin Receptor  
Metabolic or Endocrine Disease  
/
HY-134141 5-Octyl hydrogen L-glutamate
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate).
Drug Intermediate  
Metabolic or Endocrine Disease  
/
HY-117526 (-)-Mesembrine
(-)-Mesembrine is a serotonin transporter (SERT) inhibitor. (-)-Mesembrine inhibits serotonin reuptake. (-)-Mesembrine exerts anxiolytic, mood-enhancing and anti-addictive effects. (-)-Mesembrine is applicable to research on mild-to-moderate depression, anxiety disorders and stress-related conditions.
Serotonin Transporter  
Depression   Anxiety or Fear-Related Disease  
/
HY-P3095 α-Latrotoxin
α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-N18390 5-Methyltetrahydropteroyltri-L-glutamate
5-Methyltetrahydropteroyltri-L-glutamate is an amino acid derivative. 5-Methyltetrahydropteroyltri-L-glutamate is present in the dried extract of Allium sativum (Hisar Garlic No. 17). 5-Methyltetrahydropteroyltri-L-glutamate participates in the remethylation of homocysteine to methionine via cobalamin-independent methionine synthase. 5-Methyltetrahydropteroyltri-L-glutamate is a biomarker associated with altered one-carbon transfer reactions in glioblastoma. 5-Methyltetrahydropteroyltri-L-glutamate can be used in glioblastoma-related research.
Amino Acid Derivatives  
Glioblastoma  
/
HY-N14853 Ossamycin
Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC50s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively.

Source: Str. hygroscopicus, Var. ossamyceticus C 8158 (ATCC 15420)

Bacterial   Fungal  
Infection  
/
HY-N20639 Clerodin
Clerodin (3-Deoxycaryoptinol) is a natural diterpenoid compound that can be isolated from traditional Chinese medicinal plants such as Clerodendrum infortunatum. Clerodin exhibits caspase-3 regulation, apoptosis induction, cell cycle arrest, ROS induction and glutathione depletion effects, along with anti-cancer and antifeedant activities. It shows selective cytotoxicity against leukemia cells and breast cancer cells, but has no obvious toxicity to normal human blood cells and lymphocytes. Clerodin also reduces the feeding behavior of Helicoverpa armigera larvae on cabbage leaf discs, but has no significant contact toxicity to these larvae. Clerodin can be used in research related to acute monocytic leukemia and human breast cancer.
Caspase   Apoptosis   Reactive Oxygen Species (ROS)   Glutathione Peroxidase  
Breast Cancer   Leukemia/Lymphoma/Myeloma  
/
HY-N14658 Phosmidosine B
Phosmidosine B can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells.
Others  
Cancer  
/
HY-N14190 Macrosphelide L
Macrosphelide L is a cell adhesion inhibitor. Macrosphelide L inhibits the adhesion of HL-60 cells to HU-VEC cells with an IC50 of 5.6 μM.

Source: Periconia byssoides OUPS-N133

Others  
Cancer  
/
HY-B1473AR Serotonin (Standard)
Serotonin (Standard) is the analytical standard of Serotonin (HY-B1473A). This product is intended for research and analytical applications. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Reference Standards   5-HT Receptor   COMT   Endogenous Metabolite  
/
HY-B1173R (+)-Camphor (Standard)
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation.
Reference Standards   Bacterial  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-179551S (±)11(12)-EET-d11 Methyl ester
(±)11(12)-EET-d11 Methyl ester is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis.
Isotope-Labeled Compounds  
/
HY-W751874 Acetyl methylene blue
Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease  
/
HY-N15110 Phosmidosine
Phosmidosine can inhibit the cell cycle progression and cell morphology recovery of srcts-NRK cells. Phosmidosine A has antifungal effects.

Source: Streptomyces sp. RK-16

Fungal  
Infection  
/
HY-129440R N-(p-Coumaroyl) Serotonin (Standard)
N-(p-Coumaroyl) Serotonin (Standard) is the analytical standard of N-(p-Coumaroyl) Serotonin (HY-129440). This product is intended for research and analytical applications. N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
Reference Standards   PDGFR   ERK   Caspase   NF-κB   Toll-like Receptor (TLR)   p38 MAPK   NO Synthase   COX   MyD88   Reactive Oxygen Species (ROS)   Apoptosis  
Neurodegenerative Disease   Glioblastoma   Atherosclerosis and Inflammation   Renal Failure  
/
HY-W588263S1 Indole-3-acetyl glutamate-d4
Indole-3-acetyl glutamate-d4 (IAGlu-d4) is deuterium labeled Indole-3-acetyl glutamate. Indole-3-acetyl glutamate (IAGlu) is a derivative of the plant hormone indole-3-acetic acid (IAA). As a conjugated form of IAA, Indole-3-acetyl glutamate involves in the transport, storage, and homeostatic regulation of IAA within the plant. Indole-3-acetyl glutamate can be used for research into the effects of plant hormones on the growth and development of plants.
Isotope-Labeled Compounds   Others  
/
HY-126855S Cholic acid 7-sulfate-d4
Cholic acid 7-sulfate-d4 (7-Sulfocholic acid-d4) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.
Isotope-Labeled Compounds   G protein-coupled Bile Acid Receptor 1   MHC  
Metabolic or Endocrine Disease  
/
HY-121203S Citalopram-d4 hydrobromide
Citalopram-d4 (hydrobromide) is the deuterium labeled Citalopram hydrobromide. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI).
Isotope-Labeled Compounds   Serotonin Transporter  
Neurological, Eye or Ear Disease  
/
HY-NP144 Nerve Growth Factor 7S,murine submaxillary gland
Nerve Growth Factor 7S,murine submaxillary gland is a high-molecular-weight α2β2γ2 neurotrophic factor complex isolated from murine submaxillary glands. Nerve Growth Factor 7S,murine submaxillary gland prevents the binding of active β-NGF dimers to neuronal receptors by sequestering the receptor-interacting region of β-NGF within the complex. Nerve Growth Factor 7S,murine submaxillary gland lacks neurotrophic activity due to the sequestration of β-NGF dimers and the occlusion of receptor-binding sites. Nerve Growth Factor 7S,murine submaxillary gland can be used in research related to neurodegenerative diseases.
Biochemical Assay Reagents  
Neurodegenerative Disease  
/
HY-142598S Serotonin-d4 β-D-glucuronide
Serotonin-d4 β-D-glucuronide is the deuterium labeled Serotonin β-D-glucuronide.
Isotope-Labeled Compounds  
/
HY-126380 Nardosinonediol
Nardosinonediol (Tetrahydronardosinon) is a serotonin transporter (SERT) inhibitor.
Serotonin Transporter  
Neurological, Eye or Ear Disease  
/
HY-W749516 Voglibose-13C3
Voglibose-13C3 is the 13C-labeled Voglibose (HY-B0025). Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.
Isotope-Labeled Compounds   Glycosidase  
Metabolic or Endocrine Disease  
/
HY-N13170 Glycoside H2
Glycoside H2 is a potentiator of NGF-mediated nerve fiber outgrowth.
Others  
Neurological, Eye or Ear Disease  
/
HY-B1811R Vasopressin (Standard)
Vasopressin (Standard) is the analytical standard of Vasopressin. This product is intended for research and analytical applications. Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
Endogenous Metabolite   Reference Standards  
Neurological, Eye or Ear Disease  
/
HY-113308AS1 Taurolithocholic Acid-d5 sodium salt
Taurolithocholic Acid-d5 (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic Acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic Acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic Acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic Acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic Acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic Acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
Isotope-Labeled Compounds   Calcium Channel   Ferroptosis   PI3K   Reactive Oxygen Species (ROS)   Akt   HBV  
Metabolic or Endocrine Disease  
/
HY-70050CS Alosetron-d3 hydrochloride
Alosetron-d3 (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.
5-HT Receptor  
Neurological, Eye or Ear Disease  
/
HY-P990046 Tuparstobart
Tuparstobart (Incagn-02385) is an IgG1κ antibody targeting LAG-3. LAG-3 is an immune checkpoint receptor protein mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells.

Species: Human

LAG-3  
Inflammation or Immune System Disease   Triple-Negative Breast Cancer  
/
HY-B1145S Chlorhexidine-d8 dihydrochloride
Chlorhexidine-d8 (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).
Isotope-Labeled Compounds   Antibiotic   Bacterial   Necroptosis   Apoptosis  
Infection  
/
HY-Y1322S Triphenyl phosphate-d15
Triphenyl phosphate-d15 is the deuterium labeled Triphenyl phosphate. Triphenyl phosphate is an orally active, blood-brain barrier-permeable aryl organophosphate flame retardant and endocrine disruptor. Triphenyl phosphate disrupts mitochondrial dynamic balance through oxidative stress, induces excessive mitophagy and apoptosis, and ultimately leads to myocardial fibrosis. In the brain, Triphenyl phosphate activates the NF-κB inflammatory pathway by disrupting the gut microbiota, alters tryptophan metabolism and elevates neurotoxins, thereby inducing anxiety- and depression-like behaviors. In the skeletal and reproductive systems, Triphenyl phosphate inhibits osteoblast differentiation and induces germ cell apoptosis by suppressing the MAPK/ERK pathway and activating the JNK signal, respectively. In adipose and placental tissues, Triphenyl phosphate promotes lipid accumulation by activating the PI3K/AKT-PPARγ axis, and disrupts placental metabolism via the MAOA/ROS/NF-κB cascade, impairing neurodevelopment of offspring.
JNK   Apoptosis   Isotope-Labeled Compounds   Indoleamine 2,3-Dioxygenase (IDO)   Akt   Reactive Oxygen Species (ROS)   PPAR   ERK   NF-κB   Mitophagy   PI3K   Environmental Pollutants   p38 MAPK   Monoamine Oxidase  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Urogenital Disease  
/
HY-W040198 Phenosafranine
Phenosafranine is a phenazine dye. Phenosafranine exhibits higher binding affinity for triple-stranded RNA than for double-stranded RNA, and binds to both types of RNA via intercalation. Phenosafranine interacts with hemoglobin. Phenosafranine can be used for plant cell staining, as well as the detection of hemoglobin, dopamine, serotonin, etc.
Fluorescent Dye  
/
HY-B0862S Pendimethalin-d5
Pendimethalin-d5 is the deuterium labeled Pendimethalin. Pendimethalin is an herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin inhibits cell division and cell elongation.
Isotope-Labeled Compounds  
/
HY-B0649S Propofol-d17
Propofol-d17 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties.
GABA Receptor   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-Y0069S1 N-Acetylglycine-d2
N-Acetylglycine-d2 (Aceturic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods. N-Acetylglycine is a flavor enhancer which elicits Monosodium glutamate (MSG)-like sensory experiencesN-Acetylglycine.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-P3069 γ-Neuropeptide (rabbit)
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-NP134 Flagellin from S. typhimurium
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases.
Toll-like Receptor (TLR)   MyD88   NF-κB   Interleukin Related   IFNAR  
Inflammation or Immune System Disease   Melanoma  
/
HY-W010785 Dibenzyl L-glutamate tosylate
Dibenzyl L-glutamate tosylate is a glutamic acid derivative.
Amino Acid Derivatives  
/
HY-P10809 VAMP
VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 1.00 μM and a Kd of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes.
Dipeptidyl Peptidase  
Glucose Metabolism  
/
HY-P991088 HPN536
HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation.

Species: Human

CD3  
Cancer  
/
HY-P992142 Vonaprument
Vonaprument (ANX-007) is an intravitreally injected C1q antibody fragment (with a molecular weight of approximately 48 kDa) and a human monoclonal antibody. Vonaprument inhibits the activation of the classical complement cascade by specifically recognizing the globular head of C1q and blocking substrate binding. After intravitreal injection, Vonaprument distributes to the retina, choroid and optic nerve, and achieves complete C1q target binding in the aqueous humor and retinal tissues. Vonaprument can be used in research related to neurodegenerative eye diseases such as age-related macular degeneration and glaucoma.

Species: Human

Complement System  
Metabolic or Endocrine Disease   Neurodegenerative Disease   Glaucoma  
/
HY-NP143 Nerve Growth Factor 2.5S,murine submaxillary gland
Nerve Growth Factor 2.5S,murine submaxillary gland is a neurotrophic polypeptide and protein growth factor isolated from murine submaxillary glands. Nerve Growth Factor 2.5S,murine submaxillary gland increases the survival rate, phagocytic capacity and superoxide anion production level of mouse cells. Nerve Growth Factor 2.5S,murine submaxillary gland acts through cell membrane surface receptors to mediate the differentiation and maintenance of adrenergic neurons in the sympathetic nervous system. Nerve Growth Factor 2.5S,murine submaxillary gland loses its activity and undergoes dimer dissociation due to oxidation; it remains active after modification of specific tryptophan residues, while its tyrosine residues are not essential for activity. Nerve Growth Factor 2.5S,murine submaxillary gland may play a role in the inflammatory process.
Reactive Oxygen Species (ROS)   Adrenergic Receptor  
Inflammation or Immune System Disease  
/
HY-106224AS1 Orexin A-13C18,15N3 (human, rat, mouse) TFA
Orexin A-13C18,15N3 (human, rat, mouse) ((Hypocretin-1-13C18,15N3 (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
Isotope-Labeled Compounds   Orexin Receptor (OX Receptor)  
/
HY-B0172AS Isoallolithocholic acid-d2
Isoallolithocholic acid-d2 is the deuterium labeled Isoallolithocholic acid (HY-B0172A). Isoallolithocholic acid is a T cell regulator and enhances regulatory T cells (Tregs) differentiation.
Autophagy   Isotope-Labeled Compounds   Endogenous Metabolite   Apoptosis  
Neurological, Eye or Ear Disease  
/
HY-100801A DL-threo-3-Hydroxyaspartic acid
DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat.
Others  
/
HY-113080S N-Acetylornithine-d2
N-Acetylornithine-d2 is the deuterium labeled N-Acetylornithine (HY-113080). N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-B0304AS Dapoxetine-d7 hydrochloride
Dapoxetine-d7 (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI).
Serotonin Transporter  
Neurological, Eye or Ear Disease  
/
HY-Y0749A Dimethyl D-glutamate hydrochloride
Dimethyl D-glutamate hydrochloride is a glutamic acid derivative.
Amino Acid Derivatives  
/
HY-P1520A Prolactin Releasing Peptide (1-31), human acetate
Prolactin Releasing Peptide (1-31), human (acetate) is a high affinity GPR10 ligand that causes the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with Ki values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis.
GnRH Receptor  
Neurological, Eye or Ear Disease  
/
HY-P10289A Neuropeptide W-30 (rat) acetate
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-136490S Psychosine-d5
Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.
PKC  
Cancer   Neurological, Eye or Ear Disease  
/
HY-101329S Anthracene-9-carboxylic acid-d9
Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.
Chloride Channel  
/
HY-Y1365C Fish Gelatin,suitable for cell culture
Fish Gelatin,suitable for cell culture is an essential natural biopolymer. Fish Gelatin,suitable for cell culture can be isolated from fish processing by-products, such as fish skin, scales, bones and fish maw. Fish Gelatin,suitable for cell culture has been considered as a feasible substitute for mammalian gelatin. Modified Fish gelatin shows significant promise across various industries, including nanomaterials, 3D printing, thin films, coatings, and biopharmaceuticals. Fish Gelatin,suitable for cell culture can be used for cell culture.
Biochemical Assay Reagents  
/
HY-P1079 ω-Agatoxin TK
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-P1245 Neuropeptide SF (human)
Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
CRFR  
/
HY-N0737AG Harmine (GMP)
Harmine (GMP) (Telepathine (GMP)) is Harmine (HY-N0737A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.
DYRK   5-HT Receptor  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-165607S MCB-22-174
MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP).
Piezo Channel   Isotope-Labeled Compounds   ERK   CaMK  
Metabolic or Endocrine Disease  
/
HY-D2335 SERTlight
SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems.
Fluorescent Dye  
Neurological, Eye or Ear Disease  
/
HY-Y1365E Porcine skin Gelatin,suitable for cell culture(medium gel strength)
Porcine skin Gelatin, suitable for cell culture (medium gel strength) can be used to coat cells to improve cell attachment.
Biochemical Assay Reagents  
/
HY-30232 L-Glutamate-γ-benzyl ester
L-Glutamate-γ-benzyl ester is a glutamic acid derivative.
Amino Acid Derivatives  
/
HY-122808 (-)-Camphoric acid
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid induces glutamate receptor expression. Camphoric acid also significantly induces the activation of NF-κB and AP-1. Camphoric acid significantly stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Camphoric acid has weak regulatory function towards glutamate receptors. Camphoric acid can induce mRNA expression of glutamate signaling molecules and activate transcription factors, thereby stimulating osteoblast differentiation.
mGluR   NF-κB   AP-1  
Metabolic or Endocrine Disease   Pancreatic Cancer   Pain   Digestive System Inflammation  
/
HY-P99200 Fulranumab
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain.

Species: Human

Trk Receptor  
Neurological, Eye or Ear Disease  
/
HY-B0649S1 Propofol-d18
Propofol-d18 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission.
GABA Receptor   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-P99627 Frunevetmab
Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats.

Species: Felcat

Trk Receptor  
Inflammation or Immune System Disease  
/
HY-P4104 pVEC (Cadherin-5)
pVEC (Cadherin-5) is a cell-penetrating 18-amino acid-long peptide derived from the murine sequence of the cell adhesion molecule vascular endothelial cadherin. pVEC (Cadherin-5) is efficiently and rapidly taken up into cells, it can be used as a carrier peptide.
Others  
/
HY-100993 α-Methylserotonin maleate
α-Methylserotonin maleate is a potent and selective agonist of 5-HT2 receptor. α-Methylserotonin maleate is an analogue of serotonin formed in vivo from α-Methyltryptophan. α-Methylserotonin maleate mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis.
5-HT Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-A0144A Etilefrine hydrochloride
Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output.
Adrenergic Receptor   Akt   AMPK  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Obesity   Lung Fibrosis  
/
HY-P991797 Anti-Mouse IL-17A Antibody (BZN035)
Anti-Mouse IL-17A Antibody (BZN035) is an antibody targeting mouse IL-17A, which binds to and neutralizes the activity of mouse IL-17A. Anti-Mouse IL-17A Antibody (BZN035) alleviates motor symptoms in mice with experimental autoimmune encephalomyelitis and prevents atrophy of their retinal nerve fiber layer and ganglion cell-inner plexiform layer. Anti-Mouse IL-17A Antibody (BZN035) is applicable to research related to experimental autoimmune encephalomyelitis. The recommended isotype control is Mouse IgG2a kappa, Isotype Control (HY-P99978).

Species: Mouse

Interleukin Related  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-DY1009 CFDA-SE (solution)
CFDA-SE (solution) is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus. CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells.
Solvent and concentration: DMSO: 5 mM
Fluorescent Dye  
/
HY-P1520 Prolactin Releasing Peptide (1-31), human
Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with Ki values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis.
GnRH Receptor  
Neurological, Eye or Ear Disease  
/
HY-Y0367S Maleic acid-d2
Maleic Acid-d2 is the deuterium labeled Maleic Acid. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
Bacterial   Endogenous Metabolite  
Escherichia Coli Infection  
/
HY-118622 Isogentisin
Isogentisin is a cell protector. Isogentisin can shield human umbilical vein endothelial cells (HUVEC) from cell death caused by H202 and UV exposure. Isogentisin can also prevent endothelial damage triggered by smoking by activating cell repair functions to promote cell survival.
Others  
Neurological, Eye or Ear Disease  
/
HY-P2500 (Arg)9, FAM-labeled
(Arg)9, FAM-labeled, a cell-penetrating peptide (CPP), is a nona-arginine (ARG) with FAM label. CPPs have emerged as powerful tools for delivering bioactive cargoes into the cytosol of intact cells.
Fluorescent Dye  
/
HY-P991748 Anti-Human/Mouse Amphiregulin Antibody (AR37)
Anti-Human/Mouse Amphiregulin Antibody (AR37) is an antibody targeting amphiregulin (AREG), with a Kd value of 3.24 nM for the human protein and 6.40 nM for the mouse protein. Anti-Human/Mouse Amphiregulin Antibody (AR37) blocks the autocrine activation of the AREG-EGFR-ERK axis. Anti-Human/Mouse Amphiregulin Antibody (AR37) inhibits the proliferation and migration of ovarian cancer cells. Anti-Human/Mouse Amphiregulin Antibody (AR37) prolongs the survival of immunocompetent mice bearing syngeneic ovarian cancer tumors. Anti-Human/Mouse Amphiregulin Antibody (AR37) is applicable to ovarian cancer-related research.

Species: Human/Mouse

EGFR   ERK  
Ovarian Cancer  
/
HY-W025811 1-(tert-Butyl) 5-methyl L-glutamate hydrochloride
1-(tert-Butyl) 5-methyl L-glutamate hydrochloride is a glutamic acid derivative.
Amino Acid Derivatives  
/
HY-18570B 1-Naphthaleneacetic acid,suitable for plant cell culture
1-Naphthaleneacetic acid,suitable for plant cell culture (NAA) is a plant growth hormone. 1-Naphthaleneacetic acid,suitable for plant cell culture promotes plant growth and induces root cluster formation. Naphthaleneacetic acid,suitable for plant cell culture is applicable for plant cell culture.
Biochemical Assay Reagents  
/
HY-B1473R Serotonin hydrochloride (Standard)
Serotonin (5-Hydroxytryptamine) (Standard) hydrochloride is the analytical standard of Serotonin hydrochloride (HY-B1473). This product is intended for research and analytical applications. Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
5-HT Receptor   Reference Standards   COMT   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-P99195 Fasinumab
Fasinumab (Anti-Human NGF) is a human IgG4 monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies.

Species: Human

Trk Receptor  
Inflammation or Immune System Disease  
/
HY-N1428CA Ferric citrate,suitable for cell culture
Ferric citrate, suitable for cell culture is a natural preservative and food tartness enhancer. Ferric citrate, suitable for cell culture induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Ferric citrate, suitable for cell culture causes oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Ferric citrate, suitable for cell culture is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
Apoptosis   Endogenous Metabolite   Bacterial  
Cancer   Infection   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-175416 Yoda2
Yoda2 (KC289), the potassium salt of Yoda1 (HY-18723), is a PIEZO1 agonist with an EC50 of 150 nM. Yoda2 evokes Ca2+ elevation and NO-dependent relaxation. Yoda2 induces relaxation in mouse arterial and cavernous tissues. Yoda2 inhibits glucocorticoid-induced osteoclast formation and bone resorptive activity, reverses glucocorticoid-induced bone density loss and architectural deterioration, and does not induce medication-related osteonecrosis of the jaw in mice. Yoda2 can be used for the researches of hypertension and osteoporosis.
Piezo Channel   Calcium Channel  
Hypertension   Osteoporosis  
/
HY-P99677 Izenivetmab
Izenivetmab (ZTS-00075623) is an anti-NGFB IgG2κ monoclonal antibody. Izenivetmab shows anti-inflammatory and analgesic effects by targeting anti-nerve growth factor (NGF). Izenivetmab can be used for the research of osteoarthritis.

Species: Canlupfam

Trk Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Osteoarthritis  
/
HY-D0917 NIR-Red Dead Cell-1 Dye
NIR-Red Dead Cell-1 Dye is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). NIR-Red Dead Cell-1 Dye can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. NIR-Red Dead Cell-1 Dye is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. NIR-Red Dead Cell-1 Dye can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. NIR-Red Dead Cell-1 Dye can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies.
DNA Stain  
Cancer  
/
HY-118166 Gentisein
Gentisein (NSC 329491) is a metabolite of Mangiferin (HY-N0290) that inhibits the serotonin transporter (5-HT uptake system). Gentisein suppresses serotonin uptake and can be used in studies related to depression.
5-HT Receptor   Serotonin Transporter  
Depression   Alzheimer's Disease  
/
HY-129440 N-(p-Coumaroyl) Serotonin
N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
NF-κB   Toll-like Receptor (TLR)   p38 MAPK   NO Synthase   COX   ERK   Caspase   PDGFR   MyD88   Reactive Oxygen Species (ROS)   Apoptosis  
Neurodegenerative Disease   Glioblastoma   Atherosclerosis and Inflammation   Renal Failure  
/
HY-109538 Secretin (swine)
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.
Secretin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P2193 TAT-amide
TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells.
Others  
Infection  
/
HY-P990635 NGM-120
NGM-120 is a fully humanized IgG1 monoclonal antibody targeting GFRAL, which functions by blocking the GDF15-GFRAL axis. NGM-120 reduces serum GDF15 levels, increases body weight, expands central memory and proliferative CD8+ T cell populations, and decreases immunosuppressive and naive regulatory T cell populations. NGM-120 can be used for research on advanced prostate cancer.

Species: Human

TGF-β Receptor  
Prostate Cancer  
/
HY-Y0749 Dimethyl L-glutamate hydrochloride
Dimethyl L-glutamate hydrochloride (Dimethyl glutamate hydrochloride) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate hydrochloride binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate hydrochloride replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate hydrochloride can be used in research related to bone defects and non-insulin-dependent diabetes mellitus.
iGluR   Phosphatase  
Metabolic or Endocrine Disease   Musculoskeletal and Skin Disease  
/
HY-P99798 Pacanalotamab
Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3E. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines.

Species: Human

CD3  
Cancer  
/
HY-P3432 DfTat
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection.
Biochemical Assay Reagents  
/
HY-P3245A HXR9 hydrochloride
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells.
Apoptosis  
/
HY-Y0069S N-Acetylglycine-d5
N-Acetylglycine-d5 (Aceturic acid-d5) is the deuterium labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods. N-Acetylglycine is a flavor enhancer which elicits Monosodium glutamate (MSG)-like sensory experiencesN-Acetylglycine.
Isotope-Labeled Compounds   Endogenous Metabolite  
/
HY-W014666S Xanthurenic acid-d4
Xanthurenic acid-d4 is the deuterium labeled Xanthurenic acid. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
Apoptosis   mGluR   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N0442 5-O-Methylvisammioside
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the NF-κB pathway.
NF-κB   p38 MAPK   JNK   Src   TNF Receptor   NOD-like Receptor (NLR)   Amyloid-β   MEK   ERK   Ferroptosis   VEGFR   Anaplastic lymphoma kinase (ALK)   Reactive Oxygen Species (ROS)  
Liver Cancer   Depression   Hyperuricemia   Ulcerative Colitis   Liver Injury  
/
HY-P0246 Mastoparan
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

Source: a wasp venom peptide

Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P99781 Plozalizumab
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

CCR  
Cancer   Inflammation or Immune System Disease  
/
HY-Y1365L Porcine skin Gelatin,suitable for cell culture(high gel strength)
Porcine skin Gelatin,suitable for cell culture(high gel strength) can be used to coat cells to improve cell attachment.
Biochemical Assay Reagents  
/
HY-18569R 3-Indoleacetic acid (standard)
3-Indoleacetic acid (standard) (Indole-3-acetic acid (standard)) is the analytical standard of 3-Indoleacetic acid (HY-18569). This product is intended for research and analytical applications. 3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis.

Source: Human Blood, Cerebrospinal Fluid (CSF), Feces, Saliva, Urine

Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-11077 SR 146131
SR 146131 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.
Cholecystokinin Receptor  
Obesity  
/
HY-W009154 3,6-Dibromocarbazole
3,6-Dibromocarbazole is a glucocorticoid receptor (GR) inhibitor and Environmental pollutant. 3,6-Dibromocarbazole induces abnormal development of zebrafish embryos and disrupts the neurohormonal function of the hypothalamic-pituitary-adrenal axis in zebrafish larvae. 3,6-Dibromocarbazole increases the α-diversity of soil bacteria, alters community structure, enhances interspecific competition, regulates metabolic functions, and changes the abundance of genes related to nitrogen fixation, nitrification and carbon cycling. 3,6-Dibromocarbazole exerts endocrine-disrupting potential by interfering with the gluconeogenesis pathway.
Environmental Pollutants   Glucocorticoid Receptor   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-W014666R Xanthurenic acid (Standard)
Xanthurenic acid (Standard) is the analytical standard of Xanthurenic acid. This product is intended for research and analytical applications. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
Reference Standards   Endogenous Metabolite   mGluR   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-N8847 α-Ionone
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro.
Environmental Pollutants   Apoptosis   YAP   Large Tumor Suppressor (LATS)   Hippo (MST)   Olfactory Receptor  
Cancer   Digestive System Disease   Digestive System Inflammation  
/
HY-Y1365D Bovine Gelatin,suitable for cell culture
Bovine Gelatin, suitable for cell culture can be used for cell culture to induce cell attachment.
Biochemical Assay Reagents  
/
HY-W250174 Lithium 3,5-diiodosalicylate
Lithium 3,5-diiodosalicylate is a compound used in the study of bipolar disorder and other psychiatric disorders. It contains lithium and a salicylate. Lithium 3,5-diiodosalicylate works by affecting the levels of certain neurotransmitters in the brain, including dopamine and serotonin.
Biochemical Assay Reagents  
/
HY-P99297 Bedinvetmab
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.

Species: Canine

Trk Receptor  
Inflammation or Immune System Disease   Osteoarthritis  
/
HY-P99301 Lokivetmab
Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs.

Species: Canine

Interleukin Related  
Atopic Dermatitis  
/
HY-D2865 Celltrack Deep Red
Celltrack Deep Red is a fluorescent dye with a fluorescence signal that can be maintained for at least 72 h and has good stability. Celltrack Deep Red can be used for cell tracing and multi-generation cell movement tracking. Within a cell population, Celltrack Deep Red is only transferred to daughter cells and not to neighboring cells (Ex/Em = 630/650 nm).
Fluorescent Dye  
/
HY-P10000 Peptide YY (PYY) (3-36), Human
Peptide YY (PYY) (3-36), Human is an endogenous appetite-suppressing peptide that acts as a selective agonist of neuropeptide Y (NPY) Y2 receptor. Peptide YY (PYY) (3-36), Human inhibits intestinal fluid secretion, colonic propulsion, and reduces fecal output in mouse models. Peptide YY (PYY) (3-36), Human inhibits dmPGE2-, 5HT (HY-B1473A)-, and Castor oil (HY-107799)-induced diarrhea in mice. Peptide YY (PYY) (3-36), Human improves metabolic parameters and mitochondrial function in obese rat MASLD models. Peptide YY (PYY) (3-36), Human can be used for research on intestinal diseases such as diarrhea and metabolic dysfunction-associated steatotic liver disease.
Neuropeptide Y Receptor  
Digestive System Disease   Type 2 Diabetes   Obesity  
/
HY-P1514 Peptide YY (PYY), human
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P0281 TAT
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins.

Source: HIV-1

HIV  
Infection  
/
HY-P9989 Linvoseltamab
Linvoseltamab (REGN5458) is a bispecific T-cell engager (BiTE) antibody that specifically binds to B cell maturation antigen (BCMA) and CD3 of T cells, thereby directing T cells to multiple myeloma (MM) cells expressing BCMA and activating T cells to kill tumor cells. Linvoseltamab can be used in research of relapsed/refractory multiple myeloma (RRMM).

Species: Human

CD3   TNF Receptor  
Cancer  
/
HY-Y0069 N-Acetylglycine
N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods. N-Acetylglycine is a flavor enhancer which elicits Monosodium glutamate (MSG)-like sensory experiencesN-Acetylglycine.
Endogenous Metabolite  
/
HY-W019599 4-Chloro-L-phenylalanine
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease.
5-HT Receptor   Tryptophan Hydroxylase  
Parkinson's Disease  
/
HY-P99904 Siplizumab
Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody against CD2. Siplizumab depletes T cells, decreases T cell activation, inhibites T cell proliferation and enriches naïve and bona fide regulatory T cells.

Species: Human

CD2  
Cancer   Inflammation or Immune System Disease  
/
HY-P4146 Survodutide
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
GLP Receptor   GCGR  
Digestive System Disease   Digestive System Inflammation   Type 2 Diabetes   Obesity  
/
HY-P3375 Mazdutide
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D).
GCGR   GLP Receptor  
Metabolic or Endocrine Disease  
/
HY-P2273 Calcitonin (human)
Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research.
CGRP Receptor  
Metabolic or Endocrine Disease  
/
HY-P99392 Teclistamab
Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM).

Species: Human

CD3  
Cancer  
/
HY-P7660 Beta-NGF Protein, Human (HEK293)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (HEK293) is produced by HEK293 cells (S122-R239), with tag free.

Species: Human; Source: HEK293

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

/
HY-P70534 TREM-2 Protein, Human (HEK293, His)
TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2 Protein, Human (HEK293, His) is the recombinant human-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

/
HY-P70530 Beta-NGF Protein, Mouse (110a.a)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse is produced by E.coli (M130-R239), with tag free.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

/
HY-P71381 TREM-2 Protein, Mouse (HEK293, His)
TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Mouse; Source: HEK293

/
HY-P700162AF Animal-Free Beta-NGF Protein, Mouse (His)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Mouse (His) is produced by E.coli, with C-terminal His-tag.This product is for cell culture use only.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

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HY-P70449 Beta-NGF Protein, Human (120a.a)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (120a.a) is produced by E.coli (S122-A241), with tag free.

Species: Human; Source: E. coli

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

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HY-P700018AF Animal-Free Beta-NGF Protein, Human (His)
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Human (His) is produced by E.coli (S122-A241), with C-terminal His-tag.This product is for cell culture use only.

Species: Human; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

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HY-P72488 pro-Beta-NGF Protein, Human (223a.a)
Pro-Beta-NGF protein plays a crucial role in the development and maintenance of the nervous system by binding to NTRK1 and NGFR receptors. Immature NGF precursors act as ligands for the SORCS2-NGFR complex, triggering signaling pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. pro-Beta-NGF Protein, Human (223a.a) is the recombinant human-derived pro-Beta-NGF protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

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HY-P704363 Beta-NGF Protein, Mouse (HEK293)
Beta-NGF protein is essential for the development and maintenance of the nervous system and binds to NTRK1 and NGFR receptors to initiate signaling cascades that regulate neuronal processes. The NGF precursor proNGF acts as a ligand for the SORCS2-NGFR receptor and activates pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. Beta-NGF Protein, Mouse (HEK293) is the recombinant mouse-derived Beta-NGF protein, expressed by HEK293, with tag free.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Neurotrophic Factors Neurotrophins/NGF Nerve Growth Factor-β (Beta-NGF)

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HY-P71240 PSMA Protein, Mouse (HEK293, His)
PSMA Protein, a multifunctional enzyme, acts as a folate hydrolase and NAALADase with a preference for tri-alpha-glutamate peptides. In the intestine, it aids folate uptake for metabolic processes. In the brain, PSMA modulates neurotransmission by hydrolyzing NAAG, releasing glutamate. It also shows dipeptidyl-peptidase IV type activity and effectively cleaves Gly-Pro-AMC, highlighting its versatile enzymatic functions. PSMA Protein, Mouse (HEK293, His) is the recombinant mouse-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Carboxypeptidase

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HY-P72438 TREM-2 Protein, Cynomolgus (HEK293, His)
TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Cynomolgus; Source: HEK293

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HY-P704940 TREM-2 Protein, Mouse (HEK293, Fc)
TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2, Mouse (HEK293, Fc) is the recombinant mouse-derived TREM-2 protein, expressed by HEK293, with C-His labeled tag.

Species: Mouse; Source: HEK293

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HY-P76703 PSMA Protein, Human (Biotinylated, HEK293, His)
PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Biotinylated Proteins Carboxypeptidase

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HY-P701054 TREML1 Protein, Human (HEK293, hFc)
TREML1 is a trigger receptor 1 expressed on myeloid cells that activates myeloid cells via the adaptor protein DAP12. TREML1 promotes microglial phagocytosis of Aβ and is associated with the immune response to AD. TREML1 Protein, Human (HEK293, hFc) is the recombinant human-derived TREML1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P78026 PSMA Protein, Cynomolgus (HEK293, His)
PSMA protein is an important peptidase M28 family member in the M28B subfamily and plays an important role as a peptidase involved in the hydrolysis of peptide bonds. PSMA may share conserved features with related proteins, emphasizing its role in cellular processes related to peptide metabolism. PSMA Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PSMA protein, expressed by HEK293 , with N-His labeled tag.

Species: Cynomolgus; Source: HEK293

Enzymes & Regulators Carboxypeptidase

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HY-P71382 TREML1 Protein, Human (HEK293, His)
TREML1 (triggering receptor expressed on myeloid cells, like 1) is a cell surface receptor that may play a role in innate and adaptive immune responses. When phosphorylated, TREML1 interacts with the proteins PTPN6 and PTPN11, suggesting that it may be involved in regulating signaling pathways related to immune processes. TREML1 Protein, Human (HEK293, His) is the recombinant human-derived TREML1 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

Receptor Proteins

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HY-P72774 CD300LB Protein, Human (HEK293, hFc)
CD300LB Protein, an activating immune receptor, engages in immune modulation by interacting with the ITAM-bearing adapter TYROBP and recruiting GRB2 independently. The interaction with TYROBP enhances cell surface expression and activation properties. In the presence of FYN, CD300LB also interacts with GRB2, showcasing its multifaceted contribution to immune signaling pathways. CD300LB Protein, Human (HEK293, hFc) is the recombinant human-derived CD300LB protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

CD Antigens Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins CLM-7/CD300b

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HY-P700836 TREML1 Protein, Mouse (HEK293, hFc)
TREML1 is a trigger receptor 1 expressed on myeloid cells that activates myeloid cells via the adaptor protein DAP12. TREML1 promotes microglial phagocytosis of Aβ and is associated with the immune response to AD. TREML1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TREML1 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Mouse; Source: HEK293

Receptor Proteins

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HY-P702971 NFATC1 Protein, Human (sf9, GST)
NFATC1 Protein, Human (sf9, GST) is the recombinant human-derived NFATC1, expressed by Sf9 insect cells , with GST labeled tag. ,

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators

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HY-P703149 5HT2A Protein, Human (S162K, M164W, sf9, Flag, His)
5HT2A Protein, Human (S162K, M164W, sf9, Flag, His) is the recombinant human-derived 5HT2A, expressed by sf9 insect cells, with His, Flag labeled tag.,

Species: Human; Source: Sf9 insect cells

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HY-P703150 5HT2A Protein, Human (L247A, L371A, sf9, Flag, His)
5HT2A Protein, Human (L247A, L371A, sf9, Flag, His) is the recombinant human-derived 5HT2A, expressed by sf9 insect cells, with His, Flag labeled tag.,

Species: Human; Source: Sf9 insect cells

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HY-P703209 SERT Protein, Human (HEK293)
SERT Protein, Human (HEK293) is the recombinant human-derived SERT, expressed by HEK293 , with tag Free labeled tag. ,

Species: Human; Source: HEK293

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HY-P703210 SERT Protein, Human (HEK293, Strep)
SERT Protein, Human (HEK293, Strep) is the recombinant human-derived SERT, expressed by HEK293 , with Strep labeled tag. ,

Species: Human; Source: HEK293

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HY-P702805 AANAT Protein, Human (His-GST)
AANAT Protein, Human (His-GST) is the recombinant human-derived AANAT, expressed by E. coli, with N-10*His, N-GST labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P704852 FITC-Labeled PSMA Protein, Human (HEK293, His)

Species: Human; Source: HEK293

Enzymes & Regulators Fluorescent-labeled Recombinant Proteins Carboxypeptidase

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HY-P704853 PSMA Protein, Human (HEK293, Fc)
PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA, Human (HEK293, Fc) is the recombinant human-derived PSMA protein, expressed by HEK293, with C-mFc labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Carboxypeptidase

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HY-P704854 PSMA Protein, Mouse (HEK293, Fc)
The PSMA protein is a multifunctional enzyme with folate hydrolase and NAALADase activities and a preference for tri-alpha-glutamic acid peptides. It absorbs folate in the intestines, aids in important metabolic processes, and modulates excitatory neurotransmission in the brain by hydrolyzing NAAG to release glutamate. PSMA, Mouse (HEK293, Fc) is the recombinant mouse-derived PSMA protein, expressed by HEK293, with C-mFc labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Carboxypeptidase

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HY-P704937 TREM-2 Protein, Human (HEK293, mFc)
TREM-2 Protein is a receptor for amyloid beta protein 42, lipoprotein particles, and apolipoprotein. TREM-2 Protein is involved in cell proliferation and apoptosis through Wnt/β, MTOR, PI3K and NF-kappa-B signaling pathways. TREM-2 Protein is expressed by macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia to activate the immune response. TREM-2, Human (HEK293, mFc) is the recombinant human-derived TREM-2 protein, expressed by HEK293, with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P705073 PSMA Protein, Human (Biotinylated, HEK293, His-Avi)
PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PSMA protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Biotinylated Proteins Carboxypeptidase

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HY-P705074 PSMA Protein, Human (Biotinylated, HEK293, Fc-Avi)
PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived PSMA protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.

Species: Human; Source: HEK293

Enzymes & Regulators Biotinylated Proteins Carboxypeptidase

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HY-P705075 PSMA Protein, Mouse (Biotinylated, HEK293, His-Avi)
The PSMA protein is a multifunctional enzyme with folate hydrolase and NAALADase activities and a preference for tri-alpha-glutamic acid peptides. It absorbs folate in the intestines, aids in important metabolic processes, and modulates excitatory neurotransmission in the brain by hydrolyzing NAAG to release glutamate. PSMA, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived PSMA protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Biotinylated Proteins Carboxypeptidase

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HY-P705076 PSMA Protein, Mouse (Biotinylated, HEK293, Fc-Avi)
The PSMA protein is a multifunctional enzyme with folate hydrolase and NAALADase activities and a preference for tri-alpha-glutamic acid peptides. It absorbs folate in the intestines, aids in important metabolic processes, and modulates excitatory neurotransmission in the brain by hydrolyzing NAAG to release glutamate. PSMA, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived PSMA protein, expressed by HEK293, with C-Avi;C-hFc labeled tag.

Species: Mouse; Source: HEK293

Enzymes & Regulators Biotinylated Proteins Carboxypeptidase

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HY-P81121 NGF Antibody (YA3533)
NGF Antibody (YA3533) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NGF.

Host: Rabbit; Reactivity: Human, Mouse, Rat, Zebrafish

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86758 5-HT (Serotonin) Antibody (YA6451)
5-HT (Serotonin) Antibody (YA6451) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 5-HT (Serotonin).

Host: Rabbit; Reactivity: Species independent

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83029 p75 NGF Receptor Antibody (YA2774)
p75 NGF Receptor Antibody (YA2774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82477 Axin 2 Antibody (YA2222)
Axin 2 Antibody (YA2222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Axin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86115 Glutamate Receptor 1 (AMPA Subtype) Antibody (YA5807)
Glutamate Receptor 1 (AMPA Subtype) Antibody (YA5807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutamate Receptor 1 (AMPA Subtype).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82336 Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)
Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845).

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P85817 Glutamine synthetase Antibody (YA5509)
Glutamine synthetase Antibody (YA5509) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glutamine synthetase.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P86451 Melan-A Antibody (YA6143)
Melan-A Antibody (YA6143) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Melan-A.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81893 Serotonin Transporter Antibody (YA1638)
Serotonin Transporter Antibody (YA1638) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Serotonin Transporter.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81398 Ionotropic Glutamate Receptor 2 Antibody (YA1143)
Ionotropic Glutamate Receptor 2 Antibody (YA1143) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ionotropic Glutamate Receptor 2.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86524 Glutamine Synthetase Antibody (YA6216)
Glutamine Synthetase Antibody (YA6216) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutamine Synthetase.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85677 NFkB p65 Antibody (YA5369)
NFkB p65 Antibody (YA5369) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NFkB p65.

Host: Mouse; Reactivity: Human, Mouse,

Monoclonal Antibodies Primary Antibodies

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HY-P81121A NGF Antibody (YA3533)(PBS only)
NGF Antibody (YA3533) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NGF.

Host: Rabbit; Reactivity: Human, Mouse, Rat, Zebrafish

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HY-P86313 PSMA Antibody (YA6005)
PSMA Antibody (YA6005) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMA.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80407 Glutamate Receptor 1 (AMPA Subtype) Antibody (YA407)
Glutamate Receptor 1 (AMPA Subtype) Antibody (YA407) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glutamate Receptor 1 (AMPA Subtype).

Host: Rabbit; Reactivity: Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810892 Human IgG1 Antibody
Human IgG1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Human IgG1.

Host: Rabbit; Reactivity: Human

Polyclonal Antibodies Primary Antibodies

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HY-P811873 LAT2 Antibody(YA10344)
LAT2 Antibody(YA10344) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LAT2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811873A LAT2 Antibody(YA10344) (PBS only)
LAT2 Antibody(YA10344) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LAT2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811930 Ninjurin 2 Antibody(YA10401)
Ninjurin 2 Antibody(YA10401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ninjurin 2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P811930A Ninjurin 2 Antibody(YA10401) (PBS only)
Ninjurin 2 Antibody(YA10401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ninjurin 2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81398A Ionotropic Glutamate Receptor 2 Antibody (YA1143)(PBS only)
Ionotropic Glutamate Receptor 2 Antibody (YA1143) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ionotropic Glutamate Receptor 2.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82336A Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)(PBS only)
Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845).

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P82477A Axin 2 Antibody (YA2222)(PBS only)
Axin 2 Antibody (YA2222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Axin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83029A p75 NGF Receptor Antibody (YA2774)(PBS only)
p75 NGF Receptor Antibody (YA2774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p75 NGF Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83295 Melan-A Antibody (YA3040)
Melan-A Antibody (YA3040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Melan-A.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P85188 GluR-3 Antibody (YA4880)
GluR-3 Antibody (YA4880) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GluR-3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85296 NGFR p75 Antibody (YA4988)
NGFR p75 Antibody (YA4988) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to NGFR p75.

Host: Rabbit; Reactivity: Human, Rat, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85396 Trk-A Antibody (YA5088)
Trk-A Antibody (YA5088) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Trk-A.

Host: Rabbit; Reactivity: Mouse, Rat, Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85699 NFAT5 Antibody (YA5391)
NFAT5 Antibody (YA5391) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NFAT5.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

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HY-P85918 Melan-A Antibody (YA5610)
Melan-A Antibody (YA5610) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Melan-A.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86022 Melan-A Antibody (YA5714)
Melan-A Antibody (YA5714) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Melan-A.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86247 Trk pan Antibody (YA5939)
Trk pan Antibody (YA5939) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Trk pan.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86813 CHD8 Antibody (YA6506)
CHD8 Antibody (YA6506) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CHD8.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810890 5-HT2A Antibody
5-HT2A Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to 5-HT2A.

Host: Rabbit; Reactivity: Human, Mouse, Rat, Monkey, Pig, Bovine

Polyclonal Antibodies Primary Antibodies

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HY-P811130 5-HT2C Antibody
5-HT2C Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to 5-HT2C.

Host: Rabbit; Reactivity: Human, Mouse, Dog

Polyclonal Antibodies Primary Antibodies

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HY-P81744 Trk-A Antibody (YA1489)
Trk-A Antibody (YA1489) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Trk-A.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86492 NF-κB p65 Antibody (YA6184)
NF-κB p65 Antibody (YA6184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-κB p65.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P89684 5HT2A Receptor Antibody (YA9028)
5HT2A Receptor Antibody (YA9028) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to 5HT2A Receptor.

Host: Mouse; Reactivity: human, mouse, rat

Monoclonal Antibodies Primary Antibodies

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HY-K0308 Mouse CD4+ Cell Positive Selection Kit

MCE Mouse CD4+ Cells Positive Selection Kit is designed for the isolation of CD4+ cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

Cell Biology Cell Isolation

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HY-K0309 Mouse CD8+ T Cells Negative Selection Kit

MCE Mouse CD8+ T Cells Negative Selection Kit is designed for the isolation of CD8+ T cells from single cell suspensions of mouse spleen cells and lymph nodes.

Cell Biology Cell Isolation

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HY-K0354 Mouse CD3/CD28 T Cell Activation Magnetic Beads

MCE Mouse CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

Cell Biology Cell Isolation

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HY-K0357 Mouse Mature B Cell Negative Selection Kit

MCE Mouse Mature B Cell Negative Selection Kit enables the efficient isolation of mature B cells from single-cell suspensions prepared from mouse spleen, lymph nodes, or bone marrow. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells (non-B cells), followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of mouse mature B cells.

Cell Biology Cell Isolation

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HY-K1046 L-Glutamine (100×), Sterile

L-glutamine is an important amino acid supplement commonly added to mammalian cell culture media. L-glutamine serves as an auxiliary energy source, especially when cells are rapidly dividing. L-glutamine is also important in the production of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate, other amino acids, and plays a role in protein synthesis and glucose production.

Cell Biology Cell Culture Cell Culture Supplements

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HY-K2034 OptiLNP Antibody-ctLNP RNA Transfection Reagent (Human Primary T Cells)

MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology and is specifically optimized for human primary T cells. It enables efficient and targeted RNA delivery, improving transfection efficiency in difficult-to-transfect primary T cells. The kit is ideally suited for applications including CAR-T and TCR-T cell engineering, cancer immunology research, immune cell engineering, and in vitro T cell functional studies.

Cell Biology Cell Culture Cell Transfection

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HY-K3037 McCoy’s 5A (Modified) Medium

MCE McCoy's 5A Modified Medium is a nutrient-rich medium designed for culturing a wide range of cell types, particularly suitable for supporting the growth of primary cells. It is widely used for the culture of various mammalian cells, including normal and tumor-derived cells, epithelial cells, fibroblasts, bone marrow cells, and other cell types. The product specifications are based on the 500 mL format, and larger volume packages are provided as multiples of this standard specification.

Cell Biology Cell Culture Basal Cell Culture Media

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Keywords

gut-brain axis | vagal afferents | sensory nerve endings | enteroendocrine cells | neuropod cells | enterochromaffin cells | serotonin | glutamate | mechanosensation | feeding regulation