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Mechanical-Energy Decoupling In Cardiovascular Disease

Mitochondrial Dysfunction Calcium Homeostasis Cellular Stress Proteostasis

Mechanical-energy decoupling is a failure to match cardiac work with ATP production and efficient excitation-contraction coupling. In healthy myocardium, calcium links electrical activation to sarcomere shortening while mitochondrial oxidative phosphorylation replenishes ATP for myosin and calcium pumps. Heart failure disrupts this coupling through altered calcium handling, mitochondrial dysfunction, oxidative stress, cytoskeletal resistance, and abnormal loading. In reduced-ejection-fraction heart failure, impaired excitation-contraction machinery is prominent; in preserved-ejection-fraction disease, obesity, hypertension, aging, and vascular stiffness increase preload and afterload beyond the capacity of mitochondrial tricarboxylic-acid-cycle activity and ATP supply. Both routes produce inefficient work and maladaptive remodeling Mechanical load and ATP supply are normally synchronized beat by beat, so small inefficiencies become consequential when sustained across billions of contractions[1][2].

Structural systems mediate the mismatch. Cardiac microtubules support transport and organize membrane domains required for contraction, but stress-induced densification, stabilization, and post-translational modification make them mechanically resistant and increase myocardial stiffness. Junctophilin-2 maintains transverse-tubule alignment with sarcoplasmic reticulum; calpain cleavage disrupts this architecture, alters calcium homeostasis, and accelerates failure. A calpain-resistant junctophilin-2 variant preserves RYR2, CACNA1C, and ATP2A2, reduces hypertrophy and fibrosis, and slows experimental heart failure when delivered by gene therapy. These results connect proteolysis and cytoskeletal remodeling directly to energetic demand because inefficient calcium cycling consumes ATP without generating effective force Cytoskeletal stiffening increases the energetic cost of shortening, while disorganized calcium release spends ATP on ion cycling that produces less coordinated force[1][2][3].

Mitochondrial calcium provides feedback from workload to supply. Close sarcoplasmic-reticulum-mitochondrial microdomains allow calcium released through ryanodine receptors to stimulate oxidative phosphorylation, while VDAC2 contributes to mitochondrial calcium transport and can support contraction and rhythm. When this spatial unit fails, reduced ATP impairs myosin and SERCA, worsening calcium cycling in a self-reinforcing loop. Therapies include load reduction, metabolic optimization, microtubule modification, calcium-handling stabilization, junctophilin protection, and sarcomere-directed agents. Conventional catecholamine or phosphodiesterase inotropes can raise energetic demand and mortality, motivating agents that improve force without excessive intracellular calcium HFpEF and HFrEF can share energetic failure yet differ in the mechanical disturbance that initiates it, requiring different target selection and outcome measures[3][4][5][6].

The main gap is measuring coupling in patients. Ejection fraction does not quantify ATP supply, mechanical efficiency, regional load, cytoskeletal resistance, or mitochondrial reserve. Future studies should combine pressure-volume analysis, magnetic-resonance energetics, metabolic imaging, calcium and mitochondrial biomarkers, and exercise stress. Patient selection should distinguish excitation-contraction failure, excessive afterload, microtubule-related stiffness, and primary metabolic limitation. Interventions must show that improved force does not accelerate energy depletion, arrhythmia, or cell injury. The concept of myocardial fatigue suggests that some dysfunction may be transient and reversible when workload and supply are rebalanced. Precision therapy should identify the limiting link in the sarcomere-calcium-mitochondria unit and restore matched energy delivery rather than increase contraction indiscriminately Therapeutic studies should quantify efficiency as work generated per energetic cost and test whether gains persist during exercise, when reserve limitations become most visible. Repeated assessment could distinguish reversible myocardial fatigue from progressive structural failure. Rhythm and oxidative injury must be monitored concurrently[1][5][6][7].

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Cat. No. Product Name Information Application Publication
HY-15763 Erastin
Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.
VDAC   Ferroptosis   Disulfidptosis  
Cancer  
905
HY-B0015 Paclitaxel
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
Microtubule/Tubulin   ADC Payloads   Apoptosis   Autophagy  
Lung Cancer   Prostate Cancer   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Cardiovascular Disease  
396
HY-D1055 MitoSOX Red
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.
Fluorescent Dye   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism  
Cancer  
328
HY-15534 JC-1
JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm).
Fluorescent Dye  
245
HY-112879 Mito-TEMPO
Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke.
Calcium Channel   Apoptosis   Mitochondrial Metabolism   NOD-like Receptor (NLR)   PINK1/Parkin   Autophagy  
Ischemic Stroke   Osteoporosis   Chronic Kidney Disease  
186
HY-B0011 Docetaxel
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity.
Microtubule/Tubulin   Apoptosis   Endogenous Metabolite  
Prostate Cancer   Pancreatic Cancer   Viral Infection   Digestive System Inflammation   Non-Small Cell Lung Cancer   Lung Adenocarcinoma   Lung Squamous Cell Carcinoma   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
175
HY-K0601 JC-1 Mitochondrial Membrane Potential Assay Kit

MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

Cell Biology Cell Analysis Cell Apoptosis and Necrosis

169
HY-13433 Thapsigargin
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.
Calcium Channel   SARS-CoV   Apoptosis  
Cancer   Infection  
158
HY-13434 Ionomycin
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

Source: Streptomyces conglobatus

Calcium Channel   PKC   Bacterial   Apoptosis   Antibiotic  
Cancer   Infection  
138
HY-13520 Nocodazole
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.
Bcr-Abl   Apoptosis   Microtubule/Tubulin   Autophagy   Mitosis  
Digestive System Disease   Lung Cancer   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation   Alzheimer's Disease   Parkinson's Disease  
130
HY-15575 VcMMAE
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
Drug-Linker Conjugates for ADC   Microtubule/Tubulin  
97
HY-14275 Verapamil
Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.
Calcium Channel   P-glycoprotein   Cytochrome P450  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Ovarian Cancer   Viral Infection   Hypertension  
93
HY-B0166A L-Ascorbic acid sodium salt
L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.
Environmental Pollutants   Calcium Channel   Endogenous Metabolite   Apoptosis   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Pancreatic Cancer   Digestive System Inflammation   Hypertension  
91
HY-B0166 L-Ascorbic acid
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
Endogenous Metabolite   Apoptosis   Reactive Oxygen Species (ROS)   Calcium Channel  
Neurological, Eye or Ear Disease   Pancreatic Cancer   Digestive System Inflammation   Glucose Metabolism   SARS-CoV-2 Infection   Hypertension  
91
HY-L089 Mitochondria-Targeted Compound Library
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,182 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Signaling Pathway Targeting Libraries

89
HY-D0985A TMRE
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
Fluorescent Dye  
87
HY-L046 Anti-Cardiovascular Disease Compound Library
Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 2,468 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Disease Focused Libraries

84
HY-L060 Cytoskeleton Compound Library
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 2,313 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L075 Anti-Lung Cancer Compound Library
Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 3,061 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Disease Focused Libraries

84
HY-L076 Drug-Induced Liver Injury (DILI) Compound Library
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver. MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 641 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Compound Characteristic Classified Libraries

84
HY-L180 Mitophagy Compound Library
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 655 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Signaling Pathway Targeting Libraries

84
HY-L182 Fatty Acids Compound Library
Fatty acids (FAs) are the main components of lipids. The synthesis of fatty acids mainly involves the Triglyceride (TG) cycle and De Novo Lipogenesis (DNL). Fatty acids which exist widely in organisms are components of cell membranes and play an indispensable role in cell signaling. In addition, FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β-oxidation and the citric acid cycle to release large amounts of energy in the form of ATP. Abnormal fatty acid metabolism is associated with the occurrence and development of cardiovascular diseases, diabetes, fatty liver, hyperthyroidism, and other diseases. MCE offers a unique collection of fatty acid compounds. Fatty Acids Compound Library is an important tool for the study of energy metabolism and drug development of metabolism-related diseases.

Structure Classified Libraries

84
HY-L064 Glutamine Metabolism Compound Library
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 1,827 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Signaling Pathway Targeting Libraries

83
HY-L087 Anti-Obesity Compound Library
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 3,741 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Disease Focused Libraries

83
HY-L108 Antidepressant Compound Library
Depression is a serious global affective disorder and one of the most common neurological diseases whose clinical manifestations are low mood, loss of interest, anhedonia, loss of energy, and fatigue, people with major depressive disorder (MDD) can even have suicidal thoughts and behaviors. Currently available antidepressants have significant limitations, including a long time lag for a therapeutic response (weeks to months) and low response rates. This is particularly problematic for a disease with a high suicide rate. Therefore, the development of new antidepressant drugs is particularly urgent. MCE offers a unique collection of 3,059 compounds with antidepressant activities or targeting the unique targets of depression. MCE Antidepressant Compound Library is a useful tool for exploring the mechanism of depression and discovering new drugs for depression.

Disease Focused Libraries

83
HY-L118 Sodium Channel Blocker Library
Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion. MCE offers a unique collection of 199 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Signaling Pathway Targeting Libraries

83
HY-L133 Cuproptosis Compound Library
Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis". The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis. Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism. Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis. MCE supplies a unique collection of 446 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Signaling Pathway Targeting Libraries

83
HY-L144 Mitochondrial Protection Compound Library
Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases. The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 1,112 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.

Signaling Pathway Targeting Libraries

83
HY-L155 Mitochondrial Toxicity Compound Library
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity. MCE contains 545 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

Compound Characteristic Classified Libraries Signaling Pathway Targeting Libraries

83
HY-L185 Anti-Fibrosis Compound Library
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 2,568 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Disease Focused Libraries

83
HY-L193 PBCRBS Traditional Chinese Medicine Compound Library
Since ancient times, promoting blood circulation for removing blood stasis (PBCRBS) has been one of the most popular research contents in the area of traditional Chinese medicine (TCM) and integrated medicine. Rhizoma, Persicae Semen, Carthami Flos, Curcumae Longae Rhizoma and so on are common TCM with PBCRBS characteristic. Studies have shown that the mechanism of action of PBCRBS TCM is to promote blood circulation (improving cardiovascular and cerebrovascular functions, physical and chemical properties of blood, platelet and coagulation system and other physiological functions) and remove blood stasis (anti-myocardial ischemia, cerebral ischemia, inhibition of platelet aggregation, anti-coagulation, anti-thrombosis, etc.). Not only that, PBCRBS TCM has anti-infection, inhibit inflammation, regulate immune function, inhibit immune response, inhibit abnormal tissue proliferation and other functions. Therefore, PBCRBS TCM has high research value in all- field disease research fields. MCE can supply 1,006 monomer component from more than a hundred sources of PBCRBS TCM, which can be used in TCM studies, drug development and mechanism-based studies.
83
HY-L204 Lactic Acid Metabolic Compound Library
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 582 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
83
HY-L225 Cardiotoxic Compound Library
Drug development is both expensive and time-consuming, with approximately one-third of drug discontinuations caused by severe adverse drug reactions (ADRs). Among these, drug-induced cardiotoxicity (DICT) is one of the primary reasons for late-stage clinical drug failures and market withdrawals. To date, cardiotoxicity has been observed in multiple drug classes, such as anticancer drugs, antipsychotics, antidepressants, antibiotics, and neurodegenerative disease medications. To reduce cardiac ADRs, it is crucial to determine the clinical relevance of DICT to treatment, elucidate the underlying molecular mechanisms, identify reliable biomarkers, and develop new diagnostic and therapeutic approaches. MCE offers 260 cardiotoxicity compounds, including some FDA-approved drugs as well as inhibitors/blockers of the hERG potassium channel.
83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L257 Azide PROTAC Linker Library
Linkers, as key structural units in PROTAC molecules that connect the two functional ends, not only determine the overall molecular conformation and spatial compatibility but also directly influence the stability of the ternary complex, as well as cellular permeability and degradation efficiency. In recent years, with the widespread application of click chemistry in medicinal chemistry, the incorporation of bioorthogonal reactive groups such as azides (-N3) into PROTAC linker design has become an emerging research focus, providing an important tool for modular assembly and rapid structural optimization. The MCE Azide PROTAC Linker Library contains 0 linkers specifically designed for targeted protein degradation molecule design and optimization. These linkers serve as efficient “click handles,” enabling rapid and highly selective covalent coupling with alkyne reaction partners, thereby facilitating modular assembly and structural diversification of PROTAC molecules. In drug development, this design not only improves the efficiency of molecular construction but also significantly accelerates the screening and optimization of lead compounds. Meanwhile, by tuning linker properties such as length, flexibility, and polarity, the ability to form ternary complexes and degradation activity can be optimized.
83
HY-L923 Ion Channel Lead-like Compound Library
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields. MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Focused and target libraries

83
HY-LD002 DEL B Kit Regular Library
The discovery of hit molecule is a cornerstone of drug development. Among the diverse tools available, DNA-encoded libraries have emerged a revolutionary platform for high-throughput screening. Compared with traditional HTS, DEL features shorter screening processes, lower costs, simpler assays, and larger library capacities. DEL Construction utilizes split-and-pool synthesis, a combinatorial chemistry approach that involves iterative splitting, reaction, and pooling. This strategy enables rapid, exponential assembly of fragments in minimal steps without the need for individual compound synthesis andassoicicated isolation or purification steps, thus greatly reducing overall costs. The technology enables simultaneous affinity screeningof massive compound collections to target proteins in a single step. By coupling chemical structures with unique DNA barcodes, each compound is tagged with a distinct DNA sequence for convenient tracking and decoding.DELs readily enable the construction and efficient screening of libraries containing millions to billions of compounds. As a result, DEL screening combines the dual advantages of high efficiency and low cost, making DEL a transformative technology in modern drug discovery. The DEL kit consists of 50 independent libraries with a total scale of 100 billion compounds. It is constructed through stepwise combinatorial chemistry strategies involving 2-, 3-, and 4-round synthesis. By employing diverse scaffolds and flexible linking strategies, it encompasses various ring systems, linear frameworks, and heterocyclic structures. Screening can be achieved solely through affinity, independent of target-specific activity detection methods. This library is suitable for DEL screening against a wide range of targets.

DNA Encoded Libraries

83
HY-W009724 2-Aminoethyl diphenylborinate
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue.
Calcium Channel   TRP Channel   CRAC Channel  
Inflammation or Immune System Disease   Pain   Hypertension   Lung Fibrosis  
82
HY-N0488 Vincristine sulfate
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas.
Apoptosis   Microtubule/Tubulin   Mitosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Lung Cancer   Viral Infection   Digestive System Inflammation  
79
HY-16569 Colchicine
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.
Environmental Pollutants   Microtubule/Tubulin   Autophagy   Apoptosis   NOD-like Receptor (NLR)  
Digestive System Disease   Lung Cancer   Prostate Cancer   Viral Infection   Coronavirus Infection   Depression   Pain   Autoimmune Disease   Digestive System Inflammation   Alzheimer's Disease   Lung Fibrosis  
77
HY-17412 Minocycline hydrochloride
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
Bacterial   Antibiotic   HIF/HIF Prolyl-Hydroxylase   Apoptosis   MDM-2/p53   Potassium Channel   Calcium Channel  
Metabolic or Endocrine Disease   Breast Cancer   Colorectal Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Depression   Digestive System Inflammation   Cardiovascular Disease   SARS-CoV-2 Infection   Lung Fibrosis  
76
HY-15162 Monomethyl auristatin E
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
Microtubule/Tubulin   ADC Payloads   Apoptosis  
Non-Small Cell Lung Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
61
HY-108841 Raleukin
Raleukin (Kineret) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction.

Species: Human

Interleukin Related  
Metastatic Breast Cancer   SARS-CoV-2 Infection   Rheumatoid Arthritis  
57
HY-B0445A NAD sodium
NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance.
Endogenous Metabolite  
Glucose Metabolism  
53
HY-13813 Blebbistatin
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration.
Myosin  
49
HY-D0711 Indocyanine green
Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography (Ex/Em = 785/813 nm).
Fluorescent Dye  
Cancer  
49
HY-D0984 TMRM
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
Fluorescent Dye  
Inflammation or Immune System Disease  
44
HY-D0984A TMRM Perchlorate
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
Fluorescent Dye  
44
HY-B0282 Acetylcholine chloride
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent and BBB-permeable cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.
nAChR   Calcium Channel   Endogenous Metabolite  
Breast Cancer   Viral Infection   Alzheimer's Disease  
33
HY-W250119 Calcium disodium edetate hydrate
Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn2+, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold.
Biochemical Assay Reagents   Fungal   Mitochondrial Metabolism  
Fungal Infection   Plant Infection  
29
HY-D0816 Rhodamine 123
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
Fluorescent Dye  
Blood or Cardio-cerebrovascular Disease  
29
HY-13441 (-)-Blebbistatin
(-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II.
Myosin  
Cancer   Blood or Cardio-cerebrovascular Disease  
29
HY-18980 Rottlerin
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection.
PKC   Autophagy   Apoptosis   HIV   RABV  
Cancer   Digestive System Disease   Viral Infection   Digestive System Inflammation  
26
HY-N6687 Calcimycin
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy.

Source: Streptomyces chartreusensis

Oxidative Phosphorylation   Bacterial   Fungal   Apoptosis   Autophagy   Antibiotic  
Cancer   Digestive System Disease   Bacterial Infection   Fungal Infection   Digestive System Inflammation  
26
HY-15417 ML-7 hydrochloride
ML-7 hydrochloride is a selective and highly specific myosin light chain kinase (MLCK) inhibitor that acts as a trabecular meshwork (TM) relaxant. ML-7 hydrochloride enhances Quinocetone (HY-123581)-induced phosphorylation of ERK, p38 MAPK and JNK, attenuates Akt activation, and promotes apoptosis of hepatocellular carcinoma cells. ML-7 hydrochloride reduces Th2 cytokine secretion by inhibiting MLCK, while alleviating smooth muscle hyperplasia and collagen deposition. As a non-antibiotic adjuvant, ML-7 hydrochloride restores the sensitivity of drug-resistant bacteria to Tigecycline (HY-B0117). ML-7 hydrochloride can be used in research related to glaucoma, hepatocellular carcinoma, asthma, and Klebsiella pneumoniae infection.
Myosin   ERK   JNK   p38 MAPK   Akt   Apoptosis   Bacterial  
Bacterial Infection   Hepatitis B Virus Related Hepatocellular Carcinoma   Glaucoma   Asthma  
25
HY-D0086 DIDS sodium salt
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research.
VDAC   RAD51  
Cancer  
23
HY-W105518 L-Carnitine tartrate
L-Carnitine tartrate is a highly polar, small zwitterion. L-Carnitine tartrate is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine tartrate functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine tartrate is an antioxidant. L-Carnitine tartrate can ameliorate metabolic imbalances in many inborn errors of metabolism[3].
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
22
HY-17389 Genipin
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.
Autophagy  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Glucose Metabolism  
22
HY-K1060 Mitochondria Isolation Kit for Cultured Cells

MCE Mitochondria Isolation Kit for Cultured Cells enables the fast and efficient isolation of intact mitochondria from cells using differential centrifugation.


Cell Biology Cell Analysis Mitochondrial Isolation

21
HY-129122 VBIT-4
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases.
VDAC  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
20
HY-109037 Mavacamten
Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
Myosin  
Cardiovascular Disease   SARS-CoV-2 Infection  
16
HY-12273 DMH-1
DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons.
TGF-β Receptor   Organoid   Microtubule/Tubulin  
Neurological, Eye or Ear Disease   Heart Disease  
15
HY-F0001 NADH disodium salt
NADH disodium salt (Disodium NADH) is an orally effective reduced coenzyme. NADH disodium salt plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium salt regulates calcium homeostasis by promoting the opening of IP3-gated Ca2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium salt is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction.
Endogenous Metabolite   Calcium Channel   VDAC  
Neurodegenerative Disease   Cerebrovascular Disease   Cellular Senescence  
11
HY-108937 NSC 15364
NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
VDAC   Apoptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation   Cardiovascular Disease  
10
HY-100912 W-7 hydrochloride
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.
Phosphodiesterase (PDE)   Myosin   Apoptosis   Calmodulin   Potassium Channel  
Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Digestive System Inflammation   Alzheimer's Disease  
10
HY-K1061 Mitochondria Isolation Kit for Tissue

MCE Mitochondria Isolation Kit for Tissue enables the fast and efficient isolation of intact mitochondria from tissue using differential centrifugation.


Cell Biology Cell Analysis Mitochondrial Isolation

10
HY-135885 VBIT-12
VBIT-12 is a potent VDAC1 inhibitor. VBIT-12 directly interacts with VDAC1 and prevents VDAC1 oligomerization, and thus inhibits apoptotic action of VDAC1.
VDAC  
Neurological, Eye or Ear Disease  
9
HY-15579 MMAF
MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.
Microtubule/Tubulin   ADC Payloads  
9
HY-P9921 Trastuzumab emtansine
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer.
Antibody-Drug Conjugates (ADCs)   EGFR  
HER-2 Positive Breast Cancer   Metastatic Breast Cancer  
8
HY-P99974 Nab-Paclitaxel
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11).
Microtubule/Tubulin   Apoptosis   Autophagy  
Non-Small Cell Lung Cancer   HER-2 Positive Breast Cancer   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
8
HY-N0391A L-Citrulline DL-malate
L-Citrulline (DL-malate) is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate also plays an important role in some industrial fields, for example, it is used in the field of agriculture to enhance plant immunity.
Endogenous Metabolite  
7
HY-D2295 Mito-FerroGreen
Mito-FerroGreen is a mitochondria-specific Fluorescent indicator used to detect mitochondrial Fe2+ levels (excitation: 488 nm; emission: 500-550 nm). Mito-FerroGreen can be applied to research related to colorectal cancer and chronic heart failure.
Fluorescent Dye  
Colorectal Cancer   Heart Failure  
7
HY-15552 Podofilox
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.
Microtubule/Tubulin  
Lung Cancer   Viral Infection  
6
HY-W250303A Malic acid disodium hydrate
Malic acid disodium hydrate is an organic compound that is commonly used as a food additive, buffering agent, and nutritional supplement. It contains sodium and malic acid. Malic acid disodium hydrate has a variety of properties that make it suitable for these applications, including the ability to enhance food flavor, improve texture, and regulate acidity. In addition, due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance, Malic acid disodium hydrate can be used as a dietary supplement.
Biochemical Assay Reagents  
5
HY-W250303 Malic acid disodium salt
Sodium DL-Malate is an organic compound commonly used as a food additive, buffer and nutritional supplement. It contains sodium and malic acid. Malic acid disodium salt has several properties suitable for these applications, including the ability to enhance food flavor, improve texture and regulate acidity. Additionally, it can be used as a dietary supplement due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance.
Biochemical Assay Reagents  
5
HY-W018772 D-Ribose(mixture of isomers)
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner.
Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
5
HY-D0098 Fluorescein-5-maleimide
Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm.
Fluorescent Dye  
5
HY-W127780 Rhodamine 6G perchlorate
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
Fluorescent Dye  
4
HY-P99016C Enfortumab (powder)
Enfortumab (powder) is a humanized derived anti-Nectin-4 antibody that can be conjugated with the highly efficient microtubule disruptor MMAE (HY-15162) to generate the antibody agent conjugate (ADC) Enfortumab vedotin-ejfv (HY-P99016A). Enfortumab (powder) can be used for the study of locally advanced and metastatic urothelial carcinoma.
ADC Antibodies   Nectin-4  
Cancer  
4
HY-106262 Delcasertib
Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).
PKC  
Blood or Cardio-cerebrovascular Disease   Ischemia-Reperfusion Injury  
4
HY-106262B Delcasertib hydrochloride
Delcasertib (KAI-9803) hydrochloride is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).
PKC  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-N0227 7-epi-Taxol
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
Microtubule/Tubulin  
Lung Cancer  
4
HY-N2146 Combretastatin A4
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
Microtubule/Tubulin  
Colorectal Cancer   Leukemia/Lymphoma/Myeloma   Non-Small Cell Lung Cancer  
4
HY-D0309 Rhodamine 6G
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.
Environmental Pollutants   Fluorescent Dye  
Cancer  
4
HY-14233 Omecamtiv mecarbil
Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.
Myosin  
Cardiovascular Disease   SARS-CoV-2 Infection  
4
HY-112537A D-Glucose 6-phosphate dipotassium
D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.
Endogenous Metabolite   mTOR  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
3
HY-145237 BM213
BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury.
Complement System   Apoptosis   Reactive Oxygen Species (ROS)  
Cancer  
3
HY-N0824 Syringin
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc.
Environmental Pollutants   Autophagy  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Cardiovascular Disease  
3
HY-139465 Aficamten
Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM).
Myosin  
Cardiovascular Disease  
3
HY-12522S PF-06380101-d8
PF-06380101-d8 (Aur0101-d8) is a deuterium labeled PF-06380101 (HY-12522). PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue.
Microtubule/Tubulin   ADC Payloads  
Cancer  
2
HY-17435 4'-Demethylepipodophyllotoxin
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.
Microtubule/Tubulin  
Lung Cancer  
2
HY-128777 WEHI-9625
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.
VDAC   Apoptosis  
Cancer  
2
HY-113447 11-Dehydrocorticosterone
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Cardiovascular Disease  
2
HY-120870 para-Nitroblebbistatin
para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology.
Myosin  
2
HY-P4094 CTP
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs.
Others  
Cardiovascular Disease  
2
HY-P1428A RFRP-1(human) TFA
RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
Neuropeptide Y Receptor  
Blood or Cardio-cerebrovascular Disease  
1
HY-E70182 Hyaluronidase 2
Hyaluronidase 2 (EC:3.2.1.35; HYAL2) is a hyaluronidase. Hyaluronidase 2 cleaves high-molecular-weight hyaluronan into intermediate, ~20 kDa, and tetrasaccharide fragments. Hyaluronidase 2 directly interacts with CD44 and ERM proteins, reduces CD44 hyaluronan binding capacity and ERM activation. Hyaluronidase 2 can be used for the research of gliomas, inflammatory bowel disease, congenital heart defects, heart failure.
CD44  
Glioma   Inflammatory Bowel Disease   Heart Failure  
1
HY-W795960 D-myo-Inositol 1,4,5-trisphosphate sodium salt
D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P3 receptor with an EC50 of 0.12 μM and inhibits bovine PLC-δ1, with an IC50 of 5.4 μM for binding and an IC50 of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P2 and Ins (1,3,4,5) P4. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP2 hydrolysis and Ca2+-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways.
Biochemical Assay Reagents   Calcium Channel   Phospholipase  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-106150 Eniporide
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
Na+/H+ Exchanger (NHE)  
1
HY-P2196 ELA-32(human)
ELA-32 (human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor.
Apelin Receptor (APJ)  
Blood or Cardio-cerebrovascular Disease  
1
HY-D2171 AF488 DBCO
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm).
Fluorescent Dye  
1
HY-16022 Acetyldigitoxin
Acetyldigitoxin (Digitoxin 3'''-Acetate) is a cardiac glycoside. Acetyldigitoxin can come from the leaves of Digitalis species. Acetyldigitoxin reduces the heart rate and can be used for cardiac failure rasearch.
Others  
1
HY-P99177 Enibarcimab
Enibarcimab is a humanized, non-neutralizing monoclonal antibody targeting adrenomedullin (ADM). Enibarcimab binds to the N-terminus of ADM, retains ADM in the circulation, and mobilizes interstitial ADM to increase the level of active bio-ADM, ultimately stabilizing blood vessels. Enibarcimab can be used in research related to septic shock and acute heart failure.

Species: Human

Others  
Infection   Blood or Cardio-cerebrovascular Disease  
1
HY-B1742 Proxyphylline
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator.
Phosphodiesterase (PDE)   Adenosine Receptor  
Cancer   SARS-CoV-2 Infection   Parkinson's Disease   Hypertension  
1
HY-P99891 Rovelizumab
Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke.

Species: Human

Integrin  
Blood or Cardio-cerebrovascular Disease  
1
HY-B2246S L-Carnitine-d9 chloride
L-Carnitine-d9 (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-15933 TOPS
TOPS is a chromogenic substrate. TOPS undergoes an oxidative coupling reaction with 4-aminoantipyrine in the presence of H2O2 and nanocrystalline cobalt selenide. TOPS is used in studies related to uric acid detection.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
1
HY-N6998 Paederosidic acid
Paederosidic acid is isolated from P.?scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.
Apoptosis  
Digestive System Disease   Lung Cancer   Digestive System Inflammation  
1
HY-N4104 Agaric acid
Agaric acid (Agaricinic Acid) is an orally active inhibitor of adenine nucleotide translocase found in specific fungi. Agaric acid can inhibit the biofilm formation of various bacteria such as Salmonella. Agaric acid can also induce mitochondrial permeability transition, prompting mitochondria to release Ca2+, disrupting the transmembrane potential, and causing mitochondrial swelling. In addition, Agaric acid can also inhibit citrate transport in liver mitochondria and participate in the inhibition of fatty acid synthesis, affecting multiple metabolic processes.

Source: Polyporus officinalis, Polyporus igniarius

Mitochondrial Metabolism   Bacterial   Calcium Channel  
Metabolic or Endocrine Disease   Digestive System Disease   Bacterial Infection   Digestive System Inflammation  
1
HY-129139 Cyanidin-3-O-arabinoside
Cyanidin-3-O-arabinoside is a p38 MAPK phosphorylation inhibitor. Cyanidin-3-O-arabinoside reduces the expression of VDAC1, inhibits mtROS accumulation, reverses cellular senescence, blocks excessive mitochondrial calcium influx, reduces the formation of mitochondria-associated endoplasmic reticulum membranes, and suppresses the VDAC1-IP3R1 interaction. Cyanidin-3-O-arabinoside activates hair follicle stem cell proliferation and improves the condition of slowed hair growth. Cyanidin-3-O-arabinoside is applicable to research related to colon cancer and androgenetic alopecia.
p38 MAPK   VDAC   Interleukin Related   Reactive Oxygen Species (ROS)  
Colorectal Cancer   Gonadal Disease  
1
HY-W016647 For-Met-OH
For-Met-OH (N-Formylmethionine) can be involved in the translation process of bacteria, chloroplasts, and mitochondria. For-Met-OH plays different roles in different species and organelles, such as promoting the formation of protein complexes in mitochondria and acting as a degradation signal in bacteria and yeast. The level of For-Met-OH is closely related to certain diseases, for example, For-Met-OH is a potential biomarker for metabolic disorders and poor prognosis in critically ill patients.
Endogenous Metabolite   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
1
HY-105066 Davunetide
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.
Microtubule/Tubulin   Amyloid-β  
Lung Cancer   Glucose Metabolism   Alzheimer's Disease  
1
HY-128700 Nicotinic acid mononucleotide
Nicotinic acid mononucleotide acts as a SARM1 inhibitor and a NAD+ biosynthesis intermediate, with an IC50 value of 93.3 μM against SARM1. Nicotinic acid mononucleotide exerts axon-protective effects, delays axonal degeneration, elevates NAD+ levels, enhances Sirt1 activity, improves myocardial capillary density and alleviates myocardial fibrosis. Nicotinic acid mononucleotide reverses diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD+ levels. Nicotinic acid mononucleotide is applicable to research related to cancer, multiple sclerosis, diabetic cardiomyopathy, neurodegenerative diseases and Huntington's disease.
Endogenous Metabolite   Sirtuin  
Cancer   Huntington's Disease   Multiple Sclerosis  
1
HY-W008646 7,8-Dihydro-L-biopterin
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases.
SOD   Apoptosis   NO Synthase  
Neurodegenerative Disease   Hypertension  
1
HY-D1696 MitoTracker Orange CMTMRos
MitoTracker Orange CMTMRos is a fluorescent dye that labels mitochondria within live cells utilizing the mitochondrial membrane potential (Ex/Em: 551/576 nm).
Fluorescent Dye  
1
HY-113168 Butyrylcarnitine
Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer.
Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease   Cardiovascular Disease  
1
HY-D2171A AF488 DBCO ditriethylamine
AF488 DBCO ditriethylamineis a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO ditriethylaminemediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm).
Fluorescent Dye  
1
HY-109128 Danicamtiv
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
Myosin  
Cancer  
1
HY-P99205 Glembatumumab
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity.

Species: Human

ADC Antibodies  
Lung Cancer   Melanoma   Triple-Negative Breast Cancer   Metastatic Breast Cancer  
1
HY-W012722 4-Methyl-2-oxopentanoic acid
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease.
Endogenous Metabolite   Autophagy   mTOR   SOD  
Renal Disease   Obesity  
1
HY-KD1029 Mito Red Kit

Mito Red is a red-fluorescent fluorescent probe that specifically labels mitochondria in living mammalian cells.

Cell Biology Cell Analysis Organelle Research

1
HY-N7052 Tubulysin I
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis.

Source: Myxobacteria

ADC Payloads   Microtubule/Tubulin  
Cancer  
/
HY-18204S1 Valsartan-d3
Valsartan-d3 is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-N7050 Tubulysin G
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis.

Source: Myxobacteria

ADC Payloads   Microtubule/Tubulin  
Cancer  
/
HY-N2347 Tubulysin C
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis.

Source: Archangium gephyra and Angiococcus disciformis

ADC Payloads   Microtubule/Tubulin  
Cancer  
/
HY-136610S Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d10 is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.
Isotope-Labeled Compounds   Cholinesterase (ChE)  
Neurological, Eye or Ear Disease  
/
HY-113447S 11-Dehydrocorticosterone-d10
11-Dehydrocorticosterone-d10 is the deuterium labeled 11-Dehydrocorticosterone (HY-113447). 11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast.
Isotope-Labeled Compounds   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-107131 ALM-201
ALM-201 is a peptide inhibitor of angiogenesis targeting microtubule. ALM-201 can inhibit cells migration, tubule formation and microvessel formation. ALM-201 can be used for the research of cancer.
Microtubule/Tubulin  
Cancer  
/
HY-B0817S Pyridaben-d13
Pyridaben-d13 is the deuterium labeled Pyridaben. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function.
Parasite  
Infection  
/
HY-W018772S D-Ribose-18O
D-Ribose-18O is the 18O labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-P990995A Etalanetug (Mouse IgG2a)
Etalanetug (Mouse IgG2a) (7G6 Antibody) is a mouse monoclonal antibody targeting the HVPGG motif in the microtubule-binding domain of tau protein. Etalanetug (Mouse IgG2a) reduces the levels of insoluble tau protein in multiple brain regions and inhibits the seeding and spread of pathological tau protein. Etalanetug (Mouse IgG2a) is applicable to research related to Alzheimer's disease.
Tau Protein  
Alzheimer's Disease  
/
HY-B0592S Trandolapril-d5
Trandolapril-d5 is a deuterium labeled Trandolapril (RU44570). Trandolapril is an orally active angiotensin converting enzyme (ACE) inhibitor for hypertension and congestive heart failure (CHF).
Angiotensin-converting Enzyme (ACE)  
Blood or Cardio-cerebrovascular Disease  
/
HY-B1746R Pyridoxamine 5′-phosphate (Standard)
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19.
Reference Standards   Endogenous Metabolite  
Neurological, Eye or Ear Disease  
/
HY-W018772S9 D-Ribose-d-3
D-Ribose-d-3 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-165346 Cuspidoside
Cuspidoside is a cardiac glycoside and can be used for the research of cardiovascular disease, such as heart failure.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-P2696 EP 80317
EP 80317 is a selective CD36 ligand. EP 80317 protects the heart against damage and dysfunction elicited by myocardial ischaemia and reperfusion (MI/R), along with a transient reduction in peripheral lipolysis. EP 80317 can be used for the study of cardiovascular disease.
Transmembrane Glycoprotein  
Blood or Cardio-cerebrovascular Disease  
/
HY-12879G IWP-4 (GMP)
IWP-4 (GMP) is the GMP-grade form of IWP-4 (HY-12879). IWP-4 is a Wnt inhibitor with an IC50 of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC50 of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC50 = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure.
Wnt   Casein Kinase  
Cancer   Alzheimer's Disease   Heart Failure  
/
HY-P11911 Cyclo(Val-Val-Ile-d-Ala-Trp(7-Br)-Gly)
Cyclo(Val-Val-Ile-d-Ala-Trp(7-Br)-Gly) is a cyclic peptide containing 7-bromotryptophan, designed as a precursor for Sonogashira cross-coupling to generate a BODIPY-conjugated probe selective for prefibrillar Aβ1−42 oligomers.
Biochemical Assay Reagents   Amyloid-β  
Neurological, Eye or Ear Disease  
/
HY-W653461 4,5-Dimethyloctane
4,5-Dimethyloctane is a product from n-pentane/iso-butane coupling.
Biochemical Assay Reagents  
/
HY-B0399G L-Carnitine (GMP)
L-Carnitine (GMP) is L-Carnitine (HY-B0399) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. L-Carnitine, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease  
/
HY-164107 Auristatin S
Auristatin S is a potent Auristatin payload. Auristatin S binds to the vinca-binding site on tubulin, thereby inhibiting microtubule assembly and inducing cell cycle arrest and apoptosis. Auristatin S acts as a cytotoxic component of antibody-drug conjugates (ADCs) and exerts target-specific cytotoxicity against cancer cells. Auristatin S can be used in the research of lymphoma, anaplastic large cell lymphoma and Hodgkin lymphoma.
ADC Payloads   Microtubule/Tubulin   Apoptosis  
Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
/
HY-125857B Cytochrome C (Saccharomyces cerevisiae)
Cytochrome C (Saccharomyces cerevisiae) is a type C cytochrome located in the intermembrane space of the mitochondria. As an electron carrier, Cytochrome C (Saccharomyces cerevisiae) transfers electrons between complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase, CIV) of the respiratory chain. Cytochrome C (Saccharomyces cerevisiae) can play a crucial role in triggering apoptosis by being released from the mitochondria into the cytosol.
Biochemical Assay Reagents   Apoptosis   Caspase  
Metabolic or Endocrine Disease  
/
HY-D3484 AF 532 carboxylic acid
AF 532 carboxylic acid is a derivative of Alexa Fluor 532 containing a carboxylic acid group; it is used for amide coupling reactions (Ex/Em = 531/554 nm) .
Fluorescent Dye  
/
HY-N10511 GM1a Ganglioside oligosaccharide
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses.
Others  
Inflammation or Immune System Disease  
/
HY-N11250 Scillaren A
Scillaren A is a cardiac glycoside, can be isolated from the bulbs of D. coromandeliana.
Others  
/
HY-18204S3 (Rac)-Valsartan-d9
(Rac)-Valsartan-d9 is deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
Isotope-Labeled Compounds   Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P990194 Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159)
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft.

Species: Mouse

MHC  
Inflammation or Immune System Disease  
/
HY-D3306 Tubulin-RedTracker
Tubulin-RedTracker is a paclitaxel-derived fluorescent microtubule-binding probe. Tubulin-RedTracker induces F-actin cytoskeleton defects at relatively high concentrations. (Ex/Em=652/669).
Fluorescent Dye  
/
HY-Y0747S1 Iodobenzene-d2
Iodobenzene-d2 is the deuterium labeled 1-Iodobenzene. Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl.
Isotope-Labeled Compounds  
/
HY-N15196 Andrographolide-lipoic acid
Andrographolide-lipoic acid is an Andrographolide (HY-N0191) analogue, which is formed by the coupling of Andrographolide and Lipoic acid (HY-18733). Andrographolide-lipoic acid inhibits NF-κB and has anti-diabetic and β-cell protective activities.
NF-κB  
Metabolic or Endocrine Disease  
/
HY-148978R 18:0,18:1 PS sodium (Standard)
Resorantel (Standard) is the analytical standard of Resorantel. This product is intended for research and analytical applications. 18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage.
Reference Standards   Exosomes   Endogenous Metabolite   Liposome  
Metabolic or Endocrine Disease  
/
HY-148031 MC-Ala-Ala-Asn-PAB-PNP
MC-Ala-Ala-Asn-PAB-PNP is a peptide, can be used to synthesize specifically activated micromolecular target coupling body.
ADC Linkers  
/
HY-124410S Mitoquinol-d15
Mitoquinol-d15 is deuterium labeled Mitoquinol (HY-124410). Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs.
Isotope-Labeled Compounds   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-145547S 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27
1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27 (14:0 Lyso PE-d27) is the deuterium labeled 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine. 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells .
Isotope-Labeled Compounds  
/
HY-120286 K-13
K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.

Source: M. halophytica exilisia

Drug Intermediate  
/
HY-P10104 Smac-N7, Penetratin conjugated
Smac-N7, Penetratin conjugated is a caspase activator derived from the second mitochondria-derived activator of caspases (SMAC).
Caspase  
Cancer  
/
HY-P1876D Cys-NLS
Cys-NLS is a cysteine-containing nuclear localization signal peptide derived from the simian virus 40 large T antigen, which enhances nuclear import. Cys-NLS can undergo a coupling reaction through the common backbone of Cys.
Others  
/
HY-P2687 Ularitide
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
Natriuretic Peptide Receptor (NPR)  
Blood or Cardio-cerebrovascular Disease  
/
HY-A0084S Procainamide-d4 hydrochloride
Procainamide-d4 hydrochloride is deuterated labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
Isotope-Labeled Compounds  
Cancer  
/
HY-P11472 Keratin K18-C
Keratin K18-C is a phosphopeptide corresponding to amino acids 26-38 of human K18, with a cysteine residue added at the end for coupling. Keratin K18-C can be coupled to Keyhole limpet hemocyanin via m-maleimidobenzoyl-N-hydroxysuccinimide ester.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-P5315 eNOS pT495 decoy peptide
eNOS pT495 decoy peptide is a specific decoy peptide to prevent T495 phosphorylation reduced eNOS uncoupling and mitochondrial redistribution. eNOS pT495 decoy peptide is used in ventilator-induced lung injury research.
NO Synthase  
/
HY-P991921 TNX-1500
TNX-1500 is a crystallizable fragment-modified anti-CD154 antibody. TNX-1500 contains the hu5c8 fragment antigen-binding (Fab) domain from Ruplizumab (HY-P99315) and an IgG4 Fc region engineered to reduce FcγRIIa binding. TNX-1500 has significantly weaker binding affinity to FcγRI, FcγRIIaH, FcγRIIbF, FcγRIIIaF, and FcγRIIIaV compared to hu5c8 (Kd values: 8.7 nM, 7100 nM, 4900 nM, 8000 nM, 6000 nM respectively). TNX-1500 prolongs nonhuman primate renal allograft survival, prolongs nonhuman primate cardiac allograft survival. TNX-1500 can be used for the research of allograft rejection[1].

Species: Human

TNF Receptor   Fc Receptor (FcR)  
Heart Disease   Renal Disease  
/
HY-W099504S 1-Heptanol-d15
n-Heptyl Alcohol-d15 is the deuterium labeled 1-Heptanol. 1-Heptanol (n-Heptyl alcohol) is a linear primary fatty alcohol. 1-Heptanol selectively inhibits the activating phosphorylation of SAPK/JNK and reduces the phosphorylation level of IκB-α. 1-Heptanol increases plasma membrane fluidity, decreases membrane thermal stability, alters the coupling kinetics of STIM1-ORAI1, inhibits the production of ROS and LTC4, and induces the expression of HSP70. 1-Heptanol is used in the fragrance industry due to its pleasant odor.
Isotope-Labeled Compounds  
/
HY-P991928 SGN-CD48A Antibody
SGN-CD48A Antibody an anti-human CD48 antibody. SGN-CD48A Antibody can generate antibody drug conjugate (ADC) (SGN-CD48A) with a microtubule inhibitor Monomethyl auristatin E (MMAE) (HY-15162). SGN-CD48A Antibody can be used for the study of multiple myeloma.

Species: Human

ADC Antibodies   Transmembrane Glycoprotein  
Multiple Myeloma  
/
HY-163315 YPLP
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active.
Keap1-Nrf2   AMPK  
Metabolic or Endocrine Disease  
/
HY-P1219 Jingzhaotoxin-III
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype.
Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-120521 Urodilatin
Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc.
Natriuretic Peptide Receptor (NPR)  
Neurological, Eye or Ear Disease  
/
HY-N15743 Anti-Heart Failure Agent 2
Anti-Heart Failure Agent 2 (Compound 1) is an anti-heart failure agent with anti-inflammatory activity found in processed Cornus officinalis. Anti-Heart Failure Agent 2 inhibits NO release in LPS-induced RAW264.7 cells. Anti-Heart Failure Agent 2 alleviates myocardial ischemia-reperfusion injury, reduces myocardial infarction size, and improves myocardial histopathological changes. Anti-Heart Failure Agent 2 is promising for research of heart failure.
NO Synthase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P11124 MGF24
MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research.
Apoptosis   PKC   Keap1-Nrf2   Heme Oxygenase (HO)   Drug Derivative  
Neurological, Eye or Ear Disease  
/
HY-P10285S d-KLA Peptide-d30
d-KLA Peptide (D-(KLAKLAK)2)-d30 is the deuterium labeled d-KLA Peptide (HY-P10285). d-KLA Peptide, KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models.
Isotope-Labeled Compounds   Apoptosis   Mitochondrial Metabolism   Caspase  
Cancer  
/
HY-P10162 Ac-DMQD-AMC
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP).
Caspase  
Cancer  
/
HY-P3631 SALMF amide 2
SALMF amide 2, a neuropeptide S2 from the starfish Asterias rubens, is involved in the regulation of eversion of the cardiac stomach in starfish.
Others  
Neurological, Eye or Ear Disease  
/
HY-P11638 Mitochondrial-targeted peptide BP29
Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P2696A EP 80317 acetate
EP 80317 acetate is a selective CD36 ligand. EP 80317 acetate protects the heart against damage and dysfunction elicited by myocardial ischaemia and reperfusion (MI/R), along with a transient reduction in peripheral lipolysis. EP 80317 acetate can be used for the study of cardiovascular disease.
Transmembrane Glycoprotein  
Blood or Cardio-cerebrovascular Disease  
/
HY-P4565 Phe-Arg-Arg-Gly
Phe-Arg-Arg-Gly is a polypeptide that can be used for agent coupling.
Cathepsin  
/
HY-W701476 Ethyl phenylglyoxylate-d5
Ethyl phenylglyoxylate-d5 (Ethyl benzoylformate-d5; Phenylglyoxylic acid ethyl ester-d5) is the deuterium labeled Ethyl phenylglyoxylate (HY-W016618). Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions.
Isotope-Labeled Compounds   Carboxylesterase (CES)   Drug Intermediate   Biochemical Assay Reagents  
/
HY-P10052 CBO-P11
CBO-P11 specifically binds to receptor of VEGFR-2 and is used as targeting ligand for tumor angiogenesis. CBO-P11 is modified with a nearinfrared cyanine dye bearing an alkyne function, allowing both “click” coupling on azido-modified nanoparticles and fluorescence labelling.
VEGFR  
/
HY-N20270 Trichosanthis fructus extract
Trichosanthis fructus extract is an extract of Trichosanthis fructus that can be used in research on angina pectoris, heart failure, myocardial infarction, pulmonary heart disease, and cerebral ischemia.
Others  
Pain  
/
HY-15552S Podofilox-d6
Podofilox-d6 is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.
Microtubule/Tubulin  
Cancer  
/
HY-Y1009S Methoxyacetic acid-d3
Methoxyacetic acid-d3 is the deuterium labeled Methoxyacetic acid (HY-Y1009). Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether. When the concentration of methoxyacetic acid reaches a certain level, it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria. Methoxyacetic acid is somewhat toxic.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-DY1027 Indocyanine green (solution)
Indocyanine green (Foxgreen) (solution) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography (Ex/Em = 785/813 nm) .
Solvent and concentration: DMSO: 10 mM
Fluorescent Dye  
/
HY-B1505G Acefylline (GMP)
Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research.
Adenosine Receptor   Protein Arginine Deiminase   Phosphodiesterase (PDE)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-A0144AR Etilefrine hydrochloride (Standard)
Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output.
Reference Standards   AMPK   Adrenergic Receptor   Akt  
Blood or Cardio-cerebrovascular Disease  
/
HY-P3430 JM3A
JM3A is a highly specific peptoid reagent that targets newly appears cell surface vimentin (CSV) on tumor-transformed early lung cancer cells. JM3A can detect and stain CSV by coupling with fluorophores.
Biochemical Assay Reagents  
/
HY-N10272 (±)-Avenaciolide
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation.

Source: Aspergillus avenaceaus

Fungal   Bacterial  
Bacterial Infection  
/
HY-B1729S1 Phenoxyethanol-d4
Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
Isotope-Labeled Compounds   Oxidative Phosphorylation   Bacterial   Fungal  
Infection  
/
HY-D3250 PYSNO
PYSNO is a lysosome-targeted fluorescent probe based on a pyridazinone skeleton (λem=515-565 nm, λex=405 nm) that can be used to track nitric oxide (NO) production in vivo. PYSNO exhibits a rapid, highly sensitive and highly selective "turn-on" response to endogenous and exogenous NO by blocking photoinduced electron transfer and regulating radiative decay rates. PYSNO enables precise in vivo monitoring in a mouse model of myocardial fibrosis and can be applied to the research of related diseases.
Fluorescent Dye   NO Synthase  
Cardiomyopathy  
/
HY-N15744 Anti-Heart Failure Agent 3
Anti-Heart Failure Agent 3 (Compound 2) is an anti-heart failure agent with anti-inflammatory activity found in processed Cornus officinalis. Anti-Heart Failure Agent 3 inhibits NO release in LPS-induced RAW264.7 cells. Anti-Heart Failure Agent 3 alleviates myocardial ischemia-reperfusion injury, reduces myocardial infarction size, and improves myocardial histopathological changes. Anti-Heart Failure Agent 3 is promising for research of heart failure.
NO Synthase  
Blood or Cardio-cerebrovascular Disease  
/
HY-W018772S7 D-Ribose-d-1
D-Ribose-d-1 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-P992212 Anti-CD62L Antibody (DREG-200)
Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).

Species: Human

L-Selectin  
Ischemia-Reperfusion Injury  
/
HY-D3531 TAMRA-C6-acid
TAMRA-C6-acid is a derivative of TAMRA (tetramethylrhodamine) featuring a carboxylic acid group for use in amide coupling reactions. TAMRA-C6-acid is primarily used for further bioconjugation and derivatization (Ex/Em = 553/576 nm).
Fluorescent Dye  
/
HY-N0859A Schisanhenol B
Schisanhenol B is one of the active ingredients of schisandra chinensis. Schisanhenol B is a tyrosinase inhibitor. Schisanhenol B has good binding activity with PIK3CG and can be used in the study of heart failure.
PI3K   Tyrosinase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P991895 PLG-101
PLG-101 is a human anti-CD8 antibody. PLG-101 can be used in research on acute myocardial infarction .

Species: Human

Transmembrane Glycoprotein  
Myocardial Infarction  
/
HY-N15745 Anti-Heart Failure Agent 4
Anti-Heart Failure Agent 4 (Compound 3) is an anti-heart failure agent with anti-inflammatory activity found in processed Cornus officinalis. Anti-Heart Failure Agent 4 inhibits NO release in LPS-induced RAW264.7 cells. Anti-Heart Failure Agent 4 alleviates myocardial ischemia-reperfusion injury, reduces myocardial infarction size, and improves myocardial histopathological changes. Anti-Heart Failure Agent 4 is promising for research of heart failure.
NO Synthase  
Blood or Cardio-cerebrovascular Disease  
/
HY-W018772S4 D-Ribose-13C-3
D-Ribose-13C-3 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-15581S MMAD-d8
MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
ADC Payloads   Microtubule/Tubulin  
/
HY-107629 Flutax 1
Flutax 1 is a fluorescent Paclitaxel (HY-B0015) derivative, which can be used for microtubule staining (Ex/Em = 495 nm/520 nm).
Fluorescent Dye  
Cancer  
/
HY-P3894 P34cdc2 Kinase Fragment
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis.
Microtubule/Tubulin   Mitosis  
/
HY-W014240S1 Chlorpropham-d7
Chlorpropham-d7 is the deuterium labeled Chlorpropham. Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules.
Isotope-Labeled Compounds   Plant Growth Regulators   Mitosis  
/
HY-P4754 Microtubule-Associated Protein (142-161) (human)
Microtubule-Associated Protein (142-161) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
Others  
/
HY-P3436A WLSEAGPVVTVRALRGTGSW TFA
WLSEAGPVVTVRALRGTGSW TFA is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW TFA can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure).
Exosomes  
Blood or Cardio-cerebrovascular Disease  
/
HY-164107A Auristatin S TFA
Auristatin S TFA is a potent Auristatin payload. Auristatin S TFA binds to the vinca-binding site on tubulin, thereby inhibiting microtubule assembly and inducing cell cycle arrest and apoptosis. Auristatin S TFA acts as a cytotoxic component of antibody-drug conjugates (ADCs) and exerts target-specific cytotoxicity against cancer cells. Auristatin S TFA can be used in the research of lymphoma, anaplastic large cell lymphoma and Hodgkin lymphoma.
ADC Payloads   Microtubule/Tubulin   Apoptosis  
Hodgkin Lymphoma   Diffuse Large B-cell Lymphoma  
/
HY-P11729 Mitochondria rRNA blocker
Mitochondria rRNA blocker is a PCR blocker based on peptide nucleic acid (PNA). Mitochondria rRNA blocker targets the conserved 16S rRNA sequence of mitochondria and can be used in research involving PCR, sequencing, and gene detection.
Biochemical Assay Reagents  
/
HY-P1129 AR-M1896
AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-P992358 GSK2394002
GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys.

Species: Human

ADAMTS  
Cardiovascular Disease  
/
HY-N2348 Tubulysin D
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis.

Source: Archangium geophyra、Angiococcus disciformis

ADC Payloads   Microtubule/Tubulin  
Cancer  
/
HY-P11812 MLS peptide
MLS peptide is a Mitochondria-targeting peptide. MLS peptide participates in respiratory chain function via encoding Cytochrome C oxidase.
Mitochondrial Metabolism   Cytochrome P450  
Metabolic or Endocrine Disease  
/
HY-P991590 1D09C3
1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL).

Species: Human

MHC   Apoptosis   JNK   Reactive Oxygen Species (ROS)  
Cancer  
/
HY-D2341 6FC-GABA-Taxol
6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors.
Fluorescent Dye  
Cancer  
/
HY-B1729S Phenoxyethanol-d2
Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
Isotope-Labeled Compounds   Oxidative Phosphorylation   Bacterial   Fungal  
Infection  
/
HY-78824 Glycine, N-[(1,1-dimethylethoxy)carbonyl]thio-L-phenylalanyl-, methyl ester
Glycine, N-[(1,1-dimethylethoxy)carbonyl]thio-L-phenylalanyl-, methyl ester (compound 3b) is a polypeptide compound containing sulfamide, can be used to synthesis peptide-agent coupling compounds.
Others  
/
HY-N11636 Ganoderic acid S
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway.

Source: Ganoderma lucidum

Apoptosis  
Cancer  
/
HY-P2307A Tat-NR2Baa TFA
Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.
iGluR   NO Synthase  
Neurological, Eye or Ear Disease  
/
HY-P10640 [Sar1,Thr8]-Angiotensin II
[Sar1,Thr8]-Angiotensin II is a potent angiotensin II antagonist. [Sar1,Thr8]-Angiotensin II does not alter cardiac performance. [Sar1,Thr8]-Angiotensin II might be safe for patients with cardiac disease.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-P991940 JBH492 Antibody
JBH492 Antibody is a humanized, Fc-silenced anti-CCR7 IgG1 antibody. JBH492 Antibody can generate antibody drug conjugate (ADC) (JBH492) with a maytansinoid microtubule DM4 (HY-12454). JBH492 Antibody can be used for the study of lymphoma.

Species: Human

ADC Antibodies   CCR  
Cancer  
/
HY-W018772S6 D-Ribose-d
D-Ribose-d is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gly
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-P11041 VS-IP1
VS-IP1 is an interfering peptide that blocks viperin-mediated STAT1 degradation, thereby preventing coxsackievirus B3 (CVB3)-induced acute heart failure (AHF).
STAT  
Blood or Cardio-cerebrovascular Disease  
/
HY-D1916 ATTO 594
ATTO 594 is a Fluorescent dye (excitation/emission = 603/626 nm). ATTO 594 is covalently conjugated to Mucin via carbodiimide coupling.
Fluorescent Dye   Mucin  
/
HY-B0209S Metolazone-d7
Metolazone-d7 is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
Thrombin  
Blood or Cardio-cerebrovascular Disease  
/
HY-W754654 Epothilone B-d3 (synthetic)
Epothilone B-d3 (synthetic) is the deuterium labeled Epothilone B (HY-17029). Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.
Isotope-Labeled Compounds   Apoptosis   Fungal   Antibiotic   Microtubule/Tubulin   Bacterial  
Cancer  
/
HY-W099504S1 1-Heptanol-d7
1-Heptanol-d7 is the deuterium labeled 1-Heptanol. 1-Heptanol (n-Heptyl alcohol) is a linear primary fatty alcohol. 1-Heptanol selectively inhibits the activating phosphorylation of SAPK/JNK and reduces the phosphorylation level of IκB-α. 1-Heptanol increases plasma membrane fluidity, decreases membrane thermal stability, alters the coupling kinetics of STIM1-ORAI1, inhibits the production of ROS and LTC4, and induces the expression of HSP70. 1-Heptanol is used in the fragrance industry due to its pleasant odor.
Isotope-Labeled Compounds  
/
HY-W741940 Evomonoside
Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer.
Others  
/
HY-P991906 TRPH-222 Antibody
TRPH-222 Antibody (CD22-4AP Antibody) is an anti-human CD22 antibody site-specifically modified at one site per heavy chain to express formylglycine (FG), allowing site-specific conjugation of a maytansinoid payload, a protease-insensitive spacer, and a functional group for coupling to an aldehyde on antibody FG residues. TRPH-222 Antibody can generate antibody drug conjugate (ADC) (TRPH-222) with an ADC payload and a linker. TRPH-222 Antibody can be used for the study of NHL (non-Hodgkin's lymphoma).

Species: Human

ADC Antibodies   CD22  
Cancer  
/
HY-P11702 f-MFFINTLTL
f-MFFINTLTL is a formylated nonapeptide and a natural ligand from mitochondria or bacteria. f-MFFINTLTL serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the specific vomeronasal receptor (V2rf2).
Bacterial  
/
HY-D3340 AMCA-PEG4-acid
AMCA-PEG4-acid is a derivative of AMCA featuring a carboxylic acid group for use in amide coupling reactions. It incorporates a PEG4 linker to enhance solubility and reduce steric hindrance (Ex/Em = 347/444 nm).
Fluorescent Dye  
/
HY-W099504S2 1-Heptanol-d1
1-Heptanol-d1 is the deuterium labeled 1-Heptanol. 1-Heptanol (n-Heptyl alcohol) is a linear primary fatty alcohol. 1-Heptanol selectively inhibits the activating phosphorylation of SAPK/JNK and reduces the phosphorylation level of IκB-α. 1-Heptanol increases plasma membrane fluidity, decreases membrane thermal stability, alters the coupling kinetics of STIM1-ORAI1, inhibits the production of ROS and LTC4, and induces the expression of HSP70. 1-Heptanol is used in the fragrance industry due to its pleasant odor.
Isotope-Labeled Compounds  
/
HY-103271 Bax inhibitor peptide, negative control
Bax inhibitor peptide, negative control is a inhibitor of Bax. Bax inhibitor peptide, negative control inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
Bcl-2 Family  
Cancer  
/
HY-P11743 Mitochondrial penetrating peptide
Mitochondrial penetrating peptide is a peptide sequence (FrFKFrFK-CONH2) that selectively transports cargo into mitochondria. Mitochondrial penetrating peptide possesses special physicochemical properties, enabling it to selectively translocate dinuclear Ru (II) polypyridine complexes into mitochondria of living mammalian cells without the aid of solvents or membrane permeabilization treatments, thus achieving precise mitochondrial localization and enrichment of the complexes while excluding their distribution in the nucleus. Mitochondrial penetrating peptide enables dynamic monitoring of mitochondrial oxygen concentration and ROS production in living mammalian cells via changes in the luminescence lifetime of the coupled Ru (II) complex.
Biochemical Assay Reagents   Reactive Oxygen Species (ROS)  
Metabolic or Endocrine Disease  
/
HY-109128S1 Danicamtiv-d3
Danicamtiv-d3 (MYK-491-d3) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-D3153 PbQ
PbQ is a tubulin inhibitor (with an IC50 of 5 μM against goat tubulin) and a fluorescent probe for cuprous ions Cu (I). PbQ can penetrate the membrane of peripheral blood mononuclear cells, form a stable 1:1 complex with Cu+ ions, and exhibits low toxicity and good biocompatibility toward macrophage cell lines. In addition, PbQ promotes tubulin degradation and disrupts the microtubule network in lung epithelial cells without affecting actin. PbQ also possesses genotoxicity by forming DNA base adducts, and it can activate caspase-3 and apoptosis-related genes, induce loss of mitochondrial membrane potential, and trigger cell apoptosis. PbQ can be used in studies related to chronic obstructive pulmonary disease.
Apoptosis   Caspase   Microtubule/Tubulin  
/
HY-P10846 HYNIC-CTP
HYNIC-CTP is a conjugate of HYNIC and CTP (cardiac-targeting peptide). HYNIC-CTP can bind with the radionuclide 99mTc through HYNIC acting as a chelator, forming 99mTc-HYNIC-CTP. 99mTc-HYNIC-CTP is specifically taken up by the heart and used for cardiac imaging, thereby facilitating research into heart diseases.
Isotope-Labeled Compounds  
Blood or Cardio-cerebrovascular Disease  
/
HY-13689G Go 6983 (GMP)
Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury.
PKC   Histone Methyltransferase   DNA Methyltransferase   DNA/RNA Synthesis  
Ischemia-Reperfusion Injury  
/
HY-107080 RPR-109891
RPR-109891 is an orally active glycoprotein IIb/IIIa peptide antagonist. RPR-109891 can decrease platelet count and reduce platelet survival time. RPR-109891 can be used for the research of cardiovascular disease, such as myocardial infarction.
Integrin  
Blood or Cardio-cerebrovascular Disease  
/
HY-D3359 Cy5.5 bis-acid
Cy5.5 bis-acid is a derivative of Cyanine5.5 (Cy5.5) containing carboxylic acid groups, used for amide coupling reactions (Ex/Em = 675/694 nm).
Fluorescent Dye  
/
HY-16569B Colchicine,suitable for plant cell culture
Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture.
Biochemical Assay Reagents   Microtubule/Tubulin  
Cancer   Inflammation or Immune System Disease  
/
HY-103321 N-Acetyl-L-leucyl-L-leucyl-L-methional
N-Acetyl-L-leucyl-L-leucyl-L-methional is a Calpain II inhibitor with an IC50 of 0.24 μM against porcine Calpain II. N-Acetyl-L-leucyl-L-leucyl-L-methional forms a stable tetrahedral adduct with the thiol group at the active site of Calpain II, thereby inhibiting proteolytic activity. N-Acetyl-L-leucyl-L-leucyl-L-methionally inhibits cathepsins in a non-selective manner. N-Acetyl-L-leucyl-L-leucyl-L-methional reduces SARS-CoV-2 infection levels in human coronary artery endothelial cells in vitro. N-Acetyl-L-leucyl-L-leucyl-L-methional can be used in research related to cataracts and coronavirus infections.
Proteasome   Calpain   SARS-CoV  
Coronavirus Infection   Cataract  
/
HY-Y1009R Methoxyacetic acid (Standard)
Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether. When the concentration of methoxyacetic acid reaches a certain level, it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria. Methoxyacetic acid is somewhat toxic.
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W744953 Carbimazole-d3
Carbimazole-d3 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
Isotope-Labeled Compounds   p38 MAPK  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-119987 Sudan orange G
Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions.
Fluorescent Dye  
/
HY-W012241S1 Dodecanedioic acid-d4
Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N8735 k-Strophanthoside
k-Strophanthoside is a cardiac glycoside compound that can be isolated from the seeds of Strophanthus kombe.
Others  
Blood or Cardio-cerebrovascular Disease  
/
HY-109037S Mavacamten-d6
Mavacamten-d6 (MYK461-d6; SAR439152-d6) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-W032022S3 1-Hexanol-d5
1-Hexanol-d5 is the deuterium labeled 1-Hexanol. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.
Mitochondrial Metabolism  
/
HY-18206S1 (S)-Lisinopril-d5 sodium
(S)-Lisinopril-d5 (sodium) (MK-521-d5 (sodium)) is deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
Isotope-Labeled Compounds   Angiotensin-converting Enzyme (ACE)  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-N4283R Coniferyl alcohol (Standard)
Coniferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation.
Reference Standards   Drug Intermediate   Fungal  
Infection   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-W032022S4 1-Hexanol-d2
1-Hexanol-d2 is deuterated labeled 1-Hexanol (HY-W032022). 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.
Isotope-Labeled Compounds   Mitochondrial Metabolism  
/
HY-P992108 Efadirelaxin alfa
Efadirelaxin alfa (RELAX10) is a highly selective agonist of relaxin/insulin-like family peptide receptor RXFP1. After subcutaneous administration in animal experiments, Efadirelaxin alfa exhibits a significantly prolonged terminal half-life (7 days in mice, 3.75 days in rats), and shows no activity against related receptors such as RXFP2 and RXFP3. Efadirelaxin alfa has significant anti-cardiac hypertrophy and anti-fibrotic effects. Efadirelaxin alfa effectively attenuates and reverses cardiac hypertrophy and collagen deposition by regulating the TGF-β1/Smad2 and AKT/eNOS signaling pathways. Efadirelaxin alfa improves cardiac systolic function without causing fluctuations in blood pressure or heart rate, demonstrating favorable safety. Efadirelaxin alfa is currently mainly used in studies related to heart failure.

Species: Human

RXFP Receptor   Akt   NO Synthase   VEGFR  
Heart Failure  
/
HY-109037S2 Mavacamten-d1
Mavacamten-d1 (MYK461-d1; SAR439152-d1) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-W032022S2 1-Hexanol-d3
1-Hexanol-d3 is the deuterium labeled 1-Hexanol. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.
Isotope-Labeled Compounds   Mitochondrial Metabolism  
/
HY-B0558S Carbimazole-d5
Carbimazole-d5 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-114625 Amquinate
Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection).

Source: Mitochondria from Eimeria tenella

Parasite   Mitochondrial Metabolism  
Parasitic Infection  
/
HY-18206S2 Lisinopril-13C5,15N
Lisinopril-13C5,15N (MK-521-13C5,15N) is 13C and 15N labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
Isotope-Labeled Compounds  
Cancer   Blood or Cardio-cerebrovascular Disease  
/
HY-116054 Ibulocydine
Ibulocydine is an isobutyrate prodrug of the Cdk inhibitor BMK-Y101 (HY-188159), with oral activity, and exhibits IC50 values of approximately 50 nM against CDK1/CDK2, 530 nM against CDK7/cyclin H/Mat1, and 85 nM against CDK9/cyclin T. Ibulocydine reduces the phosphorylation levels of Rb, nucleolin, and RNA polymerase II CTD Ser-5 and Ser-2, downregulates the expression of Mcl-1, survivin, and XIAP, decreases MMP-9 expression, and lowers the Bcl-2/Bax ratio, activates calpain-mediated Bax cleavage, cytochrome c release, and caspase activation. Ibulocydine induces apoptosis, inhibits the growth of cancer cells and xenografts, enhances the sensitivity of cancer cells to TRAIL and radiotherapy, and blocks cancer cell metastasis. Ibulocydine can be used in research related to various cancers, including hepatocellular carcinoma, triple-negative breast cancer, lung cancer, and colon cancer.
CDK   DNA/RNA Synthesis   Survivin   MMP   Bcl-2 Family   Calpain   Caspase   Apoptosis  
Lung Cancer   Colorectal Cancer   Liver Cancer   Triple-Negative Breast Cancer  
/
HY-18204S Valsartan-d9
Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-118824 Moschamine
Moschamine acts as an inhibitor of excessive superoxide production in mitochondria.
Endogenous Metabolite  
/
HY-P3429 SAMβA
SAMβA is conjugated to the cell permeable peptide TAT47-57. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
PKC  
Blood or Cardio-cerebrovascular Disease  
/
HY-P3557A Mibenratide TFA
Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research.
Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-P10641 Heart-homing peptide
Heart-homing peptide is a heart-targeting peptide with the sequence CRPPR that mediates cardiac endothelial targeting and accumulates in cardiac tissues. Heart-homing peptide mediates the translocation of liposomal and exosomal cargos across cardiac endothelium into interstitial tissues, enhances the accumulation of exosomes in the heart, and inhibits the GP130-STAT3/ERK1/2/AKT pathway. Heart-homing peptide accumulates at sites of ischemia/reperfusion, myocardial infarction and hypertrophy in mice. Heart-homing peptide can be used for the research of cardiovascular diseases.
Exosomes   STAT   ERK   Akt  
Blood or Cardio-cerebrovascular Disease  
/
HY-P11501 AAKLVFF
AAKLVFF is an oligopeptide capable of self-assembling into nanotubes. AAKLVFF can be derived from the core section of β-amyloid. AAKLVFF becomes the first methanol compatible LC alignment medium for residual dipolar coupling measurement.
Amyloid-β   Biochemical Assay Reagents  
Alzheimer's Disease  
/
HY-109128S Danicamtiv-d6
Danicamtiv-d6 (MYK-491-d6) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P11117 TAT-EE3
TAT-EE3 is a neuroprotective peptide which can uncouple TRPM2-NMDARs interaction. TAT-EE3 inhibits TRPM2-induced enhancement of NMDAR surface expression and current amplitude.TAT-EE3 protects neurons against ischemic injury in vitro and in vivo. TAT-EE3can be used for the study of ischemic stroke.
TRP Channel   iGluR   Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-N11067 Taccalonolide E
Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.
Apoptosis  
/
HY-DY1088 Fluorescein-5-maleimide (solution)
Fluorescein-5-maleimide (solution) (N-(5-Fluoresceinyl)maleimide (solution)) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm.

Solvent and concentration: DMSO: 10 mM
Fluorescent Dye  
/
HY-109128S2 Danicamtiv-d3-1
Danicamtiv-d3-1 (MYK-491-d3-1) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P99886 Pexelizumab
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction.

Species: Human

Complement System   Apoptosis  
Blood or Cardio-cerebrovascular Disease   Ischemia-Reperfusion Injury  
/
HY-W018772S14 D-Ribose-d5
D-Ribose-d5 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gl
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-128536 KMG-104AM
KMG-104AM is a Mg2+ fluorescent probe. KMG-104AM is a membrane-permeable ester-modified derivative of KMG-104, which serves as a reporter and imaging agent. KMG-104AM can track the increase in intracellular free magnesium ion concentration induced by mitochondrial uncoupling. KMG-104AM enables visualization of the three-dimensional distribution of intracellular magnesium ion concentration. KMG-104AM is applicable to research related to the functions of intracellular magnesium ions.
Fluorescent Dye  
/
HY-P11751A RES-701-3 peptide TFA
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ETB, with an IC50 of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia.
Endogenous Metabolite   Endothelin Receptor  
Fungal Infection   Hypertension   Myocardial Infarction  
/
HY-133883 Cyanine7.5 amine
Cyanine7.5 amine is a near-infrared Cy7.5-based dye and also a substrate for amide bond coupling (Ex/Em = 788 nm/808 nm). Cyanine7.5 amine contains a free amino group and can be used for coupling with activated carboxylic acid derivatives.
Fluorescent Dye  
/
HY-P2307 Tat-NR2Baa
Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.
iGluR   NO Synthase  
Neurological, Eye or Ear Disease  
/
HY-N10483 Telekin
Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity.
Apoptosis  
Cancer  
/
HY-P11638A Mitochondrial-targeted peptide BP29 acetate
Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia.
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P0181 Microtubule-associated protein tau (26-44)
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.
Tau Protein  
Neurological, Eye or Ear Disease  
/
HY-N1922 Mesaconine
Mesaconinean, an ingredient from Aconitum carmichaelii Debx., has cardiac effect.
Others  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-152006S Propionyl-L-carnitine-d3 hydrochloride
Propionyl-L-carnitine-d3 (hydrochloride) is deuterium labeled Propionyl-L-carnitine. Propionyl-L-carnitine is a carnitine derivative and has a high affinity for muscular carnitine transferase. Propionyl-L-carnitine increases cellular carnitine content, thereby allowing free fatty acid transport into the mitochondria. Propionyl-L-carnitine alleviates the symptoms of PAD through a metabolic pathway, thereby improving exercise performance.
Isotope-Labeled Compounds   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-78738G MC-Val-Cit-PAB (GMP)
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.
ADC Linkers  
Cancer  
/
HY-W145695 Chitoheptaose
Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis.
Biochemical Assay Reagents   Apoptosis   Interleukin Related   IFNAR  
Inflammation or Immune System Disease   Cardiomyopathy  
/
HY-18206S Lisinopril-d5
Lisinopril-d5 is the deuterium labeled Lisinopril. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
Isotope-Labeled Compounds   Angiotensin-converting Enzyme (ACE)  
Blood or Cardio-cerebrovascular Disease  
/
HY-N1356A (R)-Reticuline
(R)-Reticuline is a key intermediate and precursor in the biosynthetic pathway of morphinan alkaloids. (R)-Reticuline plays a central role in the metabolism of opium poppy (Papaver somniferum). (R)-Reticuline can either undergo O-methylation catalyzed by PSOMT1, or be converted to (+)-Salutaridine via regioselective and stereoselective oxidative coupling under the action of salutaridine synthase (CYP719B1). (R)-Reticuline serves as a direct precursor for the synthesis of important alkaloids such as morphine, codeine and thebaine.
Cytochrome P450  
Inflammation or Immune System Disease  
/
HY-126474S MitoB-d15 bromide
MitoB-d15 (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals.
Isotope-Labeled Compounds   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease  
/
HY-172164B FITC-lysine-dextran (MW 70kDa)
FITC-lysine-dextran, 70kDa is a dextran with lysine coupling with a fluorescent group FITC (HY-66019). Lysine-dextran exhibits higher Glu-plasminogen binding ability than dextran alone.
Fluorescent Dye  
/
HY-N12799 Digitalin
Digitalin (Digitalinum verum) is a cardiac glycoside and can be isolated from Digitalis.
Others  
/
HY-P990791 Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71+ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft.

Species: Mouse

Transferrin Receptor  
Infection   Inflammation or Immune System Disease   Lung Cancer  
/
HY-P4968 Tau Peptide (337-368) (Repeat 4 Domain)
Tau Peptide (337-368) (Repeat 4 Domain) is a 32-amino acid peptide derived from the fourth microtubule-binding repeat sequence (R4) of the tau protein. Tau Peptide (337-368) (Repeat 4 Domain) can be used in research on neurodegenerative diseases.
Tau Protein  
/
HY-16569S Colchicine-d6
Colchicine-d6 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs).
Isotope-Labeled Compounds   Microtubule/Tubulin   NOD-like Receptor (NLR)   Autophagy   Apoptosis  
Cancer  
/
HY-W018772S1 D-Ribose-13C
D-Ribose-13C is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-16569S1 Colchicine-d3
Colchicine-d3 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs).
Isotope-Labeled Compounds   Microtubule/Tubulin   NOD-like Receptor (NLR)   Autophagy   Apoptosis  
Cancer  
/
HY-N0824R Syringin (Standard)
Syringin (Standard) is the analytical standard of Syringin. This product is intended for research and analytical applications. Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc.
Reference Standards   Autophagy  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P3557 Mibenratide
Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research.
Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990264 Anti-Mouse CD70 Antibody (FR70)
Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4+, CD8+ T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models.

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-D0798 Catechol violet
Catechol violet is an efficient and versatile ligand for Cu(I)-catalyzed C-S coupling reactions. Catechol violet is also a complexometric indicator dye.
Fluorescent Dye  
/
HY-P10103 Smac-N7 peptide
Smac-N7 peptide, the seven N-terminal amino acid of the mitochondrial protein Smac (second mitochondria-derived activator of caspase), cannot pass through the cell membrane.
Caspase  
Cancer  
/
HY-P3678 Neuropeptide Y (18-36) (porcine)
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-136903 SNJ-1945
SNJ-1945 is an orally active, blood-brain barrier-penetrant Calpain inhibitor. SNJ-1945 inhibits Cathepsin L, Cathepsin B, and Ca2+ -independent proteases. SNJ-1945 suppresses ROS production and downregulates Cyclooxygenase-2 and Caspase-1. SNJ-1945 alleviates left ventricular systolic dysfunction, reduces cerebral ischemia-induced injury, and decreases the score of experimental autoimmune encephalomyelitis in mouse models. SNJ-1945 can be used in research related to post-cardiac arrest reperfusion injury, Parkinson's disease, multiple sclerosis, and proliferative retinopathy.
Reactive Oxygen Species (ROS)   Calpain   Cathepsin   COX   Caspase  
Visual System Disease   Heart Disease   Parkinson's Disease   Multiple Sclerosis  
/
HY-W070306 PDK1-IN-1
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor. PDK1-IN-1 is also useful as inhibitor of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. PDK1-IN-1 selectively inhibits microtubule affinity regulating kinase (MARK). PDK1-IN-1 can be used for researches of myeloproliferative disorders, cancer and Alzheimer's disease.
PDK-1   FGFR   Wee1   MARK  
Lung Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Pancreatic Cancer   Alzheimer's Disease   Obesity  
/
HY-P991704 Moponetug
Moponetug (PRX-005), an anti-microtubule binding region (MTBR) tau monoclonal antibody, is a humanized monoclonal tri-epitopic antibody. Moponetug binds with high affinity to the R1, R2, and R3 repeats in the MTBR region of tau, and targets both 3R and 4R tau isoforms. Moponetug can be used for the study of Alzheimer’s disease.

Species: Human

Tau Protein  
Alzheimer's Disease  
/
HY-N0542 Pseudoginsenoside RT5
Pseudoginsenoside RT5 is an orally active ocotillol-type ginsenoside and Antibacterial agent. Pseudoginsenoside RT5 can be isolated from American ginseng, transgenic American ginseng crown gall tumors and Panax japonicus. Pseudoginsenoside RT5 exerts cardioprotective effects against myocardial injury, and also possesses antibacterial and antitumor activities. Pseudoginsenoside RT5 can be used in research related to Alzheimer's disease, myocardial injury, tumors and bacterial infections.
Bacterial  
Cancer   Bacterial Infection   Heart Disease   Alzheimer's Disease  
/
HY-W032022S 1-Hexanol-d13
1-Hexanol-d13 is the deuterium labeled 1-Hexanol. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.
Isotope-Labeled Compounds   Mitochondrial Metabolism  
/
HY-W032022S1 1-Hexanol-d11
1-Hexanol-d11 is the deuterium labeled 1-Hexanol. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.
Isotope-Labeled Compounds   Mitochondrial Metabolism  
/
HY-15579AS MMAF-d8 hydrochloride
MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
Microtubule/Tubulin   ADC Payloads  
Cancer  
/
HY-P99645 Goflikicept
Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI).
Interleukin Related  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P99946 Erlizumab
Erlizumab (rhuMAb) is a monoclonal antibody against the Integrin b2/ITGB2/CD18 subunit of the Mac-1 receptor. Erlizumab can reduce reperfusion injury in myocardial infarction.

Species: Human

Integrin  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Breast Cancer  
/
HY-186130 CAST-calpain-2 stabilizer-1
CAST-calpain-2 stabilizer-1 is a blood-brain barrier permeable stabilizer of CAST-calpain-2 interaction. CAST-calpain-2 stabilizer-1 shows no activity against GSK3. CAST-calpain-2 stabilizer-1 can be used in the research of Huntington's disease and tauopathies.
Calpain  
Huntington's Disease  
/
HY-W008719S MPP+-d3iodide
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).
Mitochondrial Metabolism  
Neurological, Eye or Ear Disease  
/
HY-18204S2 Valsartan-d8
Valsartan-d8 is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
Angiotensin Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-14233S Omecamtiv mecarbil-d8
Omecamtiv mecarbil-d8 is the deuterium labeled Omecamtiv mecarbil. Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-113495 Deoxypyridinoline
Deoxypyridinoline is an endogenous metabolite present in Urine that can be used for the research of Heart Failure.
Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-172262 WEHI-3773
WEHI-3773 is a VDAC2 ligand and apoptosis modulator. WEHI-3773 directly binds to the β7-β10 region of VDAC2 and disrupts its interaction with BAX and BAK. WEHI-3773 regulates BAX-mediated apoptosis in BAK-deficient cells by modulating conformational activation of BAX, mitochondrial redistribution, and cytochrome c release. WEHI-3773 overcomes Venetoclax (HY-15531) resistance, resensitizes leukemia cells carrying BAX mutations to BH3 mimetics, and enables long-term clonogenic survival of BAK-deficient cells treated with BH3 mimetics. WEHI-3773 is applicable to research related to acute myeloid leukemia.
VDAC   Bcl-2 Family   Apoptosis  
Acute Myeloid Leukemia  
/
HY-D2502 Cy7 hydrazide
Cy7 hydrazide is a Cy7 (HY-D0825) dye derivative with hydrazine functionality. The hydrazide group of Cy7 hydrazide can form hydrazinone coupling with molecules containing aldehydes or ketones to form covalent bonds.
Fluorescent Dye  
/
HY-P3429A SAMβA TFA
SAMβA TFA is a rationally designed selective antagonist of Mfn1-βIIPKC association and can bind to TAT (HY-P0281). SAMβA TFA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
PKC  
Blood or Cardio-cerebrovascular Disease  
/
HY-P99685 Laprituximab emtansine
Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research.
EGFR   Antibody-Drug Conjugates (ADCs)  
/
HY-15407S Sacubitril-d4
Sacubitril-d4 is the deuterium labeled Sacubitril. Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.
Neprilysin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P3003S Cereulide-13C6
Cereulide-13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.
Isotope-Labeled Compounds   Mitochondrial Metabolism   Potassium Channel   Reactive Oxygen Species (ROS)   Apoptosis   Autophagy  
Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-109037S4 Mavacamten-d7
Mavacamten-d7 (MYK461-d7) is deuterium labeled Mavacamten. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-N11222 Nonanoylcarnitine
Nonanoylcarnitine is a metabolite associated with chronic environmental exposure to polycyclic aromatic hydrocarbons (PAH) and fragmented QRS waves in acute myocardial infarction. Nonanoylcarnitine can be used as a potential biomarker for the metabolic outcome of PAH exposure and the prognosis of acute myocardial infarction.
Endogenous Metabolite  
Cancer   Cardiovascular Disease  
/
HY-P4808 PHF6
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein.
Amyloid-β   Autophagy  
Neurological, Eye or Ear Disease  
/
HY-N7053 Tubulysin M
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis.

Source: Archangium gephyra

ADC Payloads   Microtubule/Tubulin  
Cancer  
/
HY-P3436 WLSEAGPVVTVRALRGTGSW
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure).
Exosomes  
Heart Disease  
/
HY-N7133 Diphenylamine hydrochloride
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent.
Fungal   Bacterial  
Bacterial Infection   Fungal Infection   Glucose Metabolism  
/
HY-P3003 Cereulide
Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning.

Source: Bacillus cereus

Potassium Channel   Apoptosis   Autophagy   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Fungal Infection  
/
HY-A0144A Etilefrine hydrochloride
Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output.
Adrenergic Receptor   Akt   AMPK  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Obesity   Lung Fibrosis  
/
HY-W018772S12 D-Ribose-d6
D-Ribose-d6 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gl
Isotope-Labeled Compounds   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease  
/
HY-NP192 Sericin
Sericin is an orally active globular protein produced by silkworm cocoons. Sericin inhibits the expression of COX2, iNOS, TLR4, MAPK and NF-κB; reduces the levels of IL-18, IL-1 and CCL2; antagonizes the activity of AChE; and downregulates the expression of Bcl-2. Sericin enhances the PI3K/AKT-mediated insulin signaling pathway. Sericin inhibits the activity of tyrosinase (Tyrosinase), scavenges ROS, chelates metal ions, and increases the levels of antioxidant enzymes. Sericin induces apoptosis and arrests the cell cycle. Sericin exhibits antibacterial, moisturizing, cardioprotective and anticoagulant properties. Sericin can be used in research related to type 2 diabetes, hyperlipidemia, obesity, Alzheimer's disease, colon cancer, peripheral nerve injury and ischemic myocardial infarction.
Reactive Oxygen Species (ROS)   Bacterial   COX   NO Synthase   Toll-like Receptor (TLR)   p38 MAPK   NF-κB   Interleukin Related   Cholinesterase (ChE)   Bcl-2 Family   Tyrosinase   PI3K   Akt  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W018772S15 D-Ribose(mixture of isomers)-13C5
D-Ribose(mixture of isomers)-13C5 isomers)-13C5 is the 13C labeled D-Ribose(mixture of isomers). D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner.
Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-132260 Naratuximab emtansine
Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis.
Antibody-Drug Conjugates (ADCs)   Apoptosis  
/
HY-14881S1 (Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d6 is the deuterium labeled Bedaquiline (HY-14881). Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis.
Isotope-Labeled Compounds   Antibiotic   Bacterial  
/
HY-N6790 Nonactin
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity.

Source: Streptomyces griseus ETH A7796

Oxidative Phosphorylation   Potassium Channel   Mitochondrial Metabolism   Bacterial   Influenza Virus   Apoptosis   Antibiotic   HSP  
Cancer   Digestive System Disease   Viral Infection   Bacterial Infection   Digestive System Inflammation   Alzheimer's Disease  
/
HY-W099504 1-Heptanol
1-Heptanol (n-Heptyl alcohol) is a linear primary fatty alcohol. 1-Heptanol selectively inhibits the activating phosphorylation of SAPK/JNK and reduces the phosphorylation level of IκB-α. 1-Heptanol increases plasma membrane fluidity, decreases membrane thermal stability, alters the coupling kinetics of STIM1-ORAI1, inhibits the production of ROS and LTC4, and induces the expression of HSP70. 1-Heptanol is used in the fragrance industry due to its pleasant odor.
JNK   Reactive Oxygen Species (ROS)   Leukotriene Receptor   HSP  
/
HY-111217 AKOS-22
AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction.
VDAC   Mitochondrial Metabolism  
Cancer   Digestive System Disease   Digestive System Inflammation   Parkinson's Disease  
/
HY-B0445AR NAD sodium (Standard)
NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP.
Endogenous Metabolite   Reference Standards  
/
HY-W087952 (R)-(-)-2-Butanol
(R)-(-)-2-Butanol is the isomer of 2-Butanol, which is found in the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol is an intermediate of pharmaceutical synthesis by coupling.

Source: endophytic bacterium ETR-B22

Drug Intermediate  
Metabolic or Endocrine Disease  
/
HY-N6811 1-Octacosanol
1-Octacosanol is a straight-chain aliphatic 28-carbon fatty alcohol and a major component of the cholesterol-lowering agent Policosanol. 1-Octacosanol exhibits various activities such as anti-fatigue, anti-angiogenic, cholesterol-lowering, and insecticidal effects.
Insecticide  
Infection   Blood or Cardio-cerebrovascular Disease  
/
HY-W032022 1-Hexanol
1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism.

Source: Alfalfa Plant Bug

Environmental Pollutants   Mitochondrial Metabolism   Biochemical Assay Reagents  
/
HY-109037S3 Mavacamten-d5
Mavacamten-d5 (MYK461-d5; SAR439152-d5) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
Isotope-Labeled Compounds   Myosin  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990951 Vixticibart
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension.

Species: Human

Natriuretic Peptide Receptor (NPR)  
Hypertension   Heart Failure  
/
HY-138207 N-Oleoyl-L-phenylalanine
N-Oleoyl-L-phenylalanine is a long-chain N-acyl-L-phenylalanine and also a mitochondrial uncoupler. N-Oleoyl-L-phenylalanine uncouples UCP1-independent respiration in mitochondria, thereby helping to regulate glucose homeostasis. As an endogenous metabolite, the level of N-Oleoyl-L-phenylalanine increases in patients with ulcerative colitis after a high-fat diet. N-Oleoyl-L-phenylalanine can be used in studies related to ulcerative colitis.
Mitochondrial Metabolism   Drug Metabolite  
Digestive System Disease   Colitis  
/
HY-Y1009 Methoxyacetic acid
Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether. When the concentration of methoxyacetic acid reaches a certain level, it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria. Methoxyacetic acid is somewhat toxic.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P990294 Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis.

Species: Mouse

Transmembrane Glycoprotein   STAT   Collagen   Reactive Oxygen Species (ROS)   Interleukin Related  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-148978 18:0,18:1 PS sodium
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage.
Exosomes   Endogenous Metabolite   Liposome  
Metabolic or Endocrine Disease  
/
HY-P4808A PHF6 TFA
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein.
Amyloid-β   Autophagy  
Neurological, Eye or Ear Disease  
/
HY-32951 2-Fluoropyridine-4-boronic acid
2-Fluoropyridine-4-boronic acid is a coupling reagent and chemical intermediate. 2-Fluoropyridine-4-boronic acid facilitates the synthesis of Rho kinase (ROCK) inhibitor Compound 37.
Drug Intermediate  
/
HY-N9608 6-Ketocholestanol
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential.
Cytochrome P450  
/
HY-Y0537B Potassium chloride, for molecular biology
Potassium chloride, for molecular biology is potassium chloride that can be used in molecular biology. Potassium chloride, for molecular biology affects the stability of biological membranes by disrupting the electrostatic interactions between proteins and lipids. Potassium chloride, for molecular biology affects the solubility of myofibrillar proteins and the integrity of mitochondria. Potassium chloride, for molecular biology is commonly used in homogenization buffers and protein extraction procedures.
Environmental Pollutants   Mitochondrial Metabolism   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-113371S 2-Methylcitric acid-d3
2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W003601 2-Bromo-4-fluoropyridine
2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.
Biochemical Assay Reagents  
/
HY-P10646 Muscle homing peptide M12
Muscle homing peptide M12 is a muscle-homing peptide with high affinity for skeletal muscle and cardiac muscle. Muscle homing peptide M12 can mediate the targeted delivery of loaded drugs to skeletal muscle and cardiac muscle tissues.
Others  
/
HY-129763 Di-4-ANEPPS
Di-4-ANEPPS is a voltage-sensitive dye that acts on voltage-gated ion channels (such as sodium channels) and inhibits sodium current, significantly reducing sodium current density, although specific values like IC50 remain unclear. It mainly binds to the voltage-sensitive regions on the cell membrane, changing its fluorescence properties to reflect membrane potential changes and thus affecting the function of ion channels to exert its activity. This substance can be used in cardiovascular research, such as the electrophysiology of cardiomyocytes, myocardial ischemia, and the effects of drugs on cardiomyocytes. It is of great value in evaluating drug cardiotoxicity and exploring the mechanisms of arrhythmias.
Fluorescent Dye  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990995 Etalanetug
Etalanetug (E2814) is a humanized high-affinity IgG1 antibody that targets tau protein and can cross the blood-brain barrier. Etalanetug inhibits the spread of pathological tau protein through high-affinity binding to the microtubule-binding region (MTBR). Etalanetug can be used in research related to Alzheimer's disease.

Species: Human

Tau Protein  
Alzheimer's Disease  
/
HY-DY1003 JC-1 (solution)
JC-1 (CBIC2) (solution) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells, tissues or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm) ; When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
Solvent and concentration: DMSO: 1.5 mM
Fluorescent Dye  
/
HY-13442AS Eribulin-d3 mesylate
Eribulin-d3 (mesylate) is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer.
Microtubule/Tubulin   Apoptosis  
Cancer  
/
HY-N4283 Coniferyl alcohol
Coniferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation.
Drug Intermediate   Fungal  
Inflammation or Immune System Disease   Fungal Infection   Cardiovascular Disease  
/
HY-Y0747 Iodobenzene
Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl.
Biochemical Assay Reagents  
/
HY-P99555 Tomaralimab
Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury.

Species: Human

Toll-like Receptor (TLR)   MyD88   NOD-like Receptor (NLR)   Tau Protein   Interleukin Related  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P991219 Anti-IL11RA Antibody (X209)
Anti-IL11RA Antibody (X209) (EnX209) is a human-derived IgG4, κ-type antibody inhibitor targeting IL11RA, with a KD of 6 nM. Anti-IL11RA Antibody (X209) blocks the IL11RA signaling pathway, inhibits ERK-dependent activation, and reduces the activation level of ERK1/2. Anti-IL11RA Antibody (X209) exerts a protective effect against fibrosis. Anti-IL11RA Antibody (X209) is applicable to studies related to liver fibrosis, cardiac fibrosis and other related conditions. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003).

Species: Human

Interleukin Related   ERK   MMP  
Inflammation or Immune System Disease  
/
HY-P99047 Simtuzumab
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis.

Species: Human

Monoamine Oxidase  
Cardiomyopathy   Lung Fibrosis  
/
HY-NP007 Myoglobin
Myoglobin is an oxygen-binding heme protein. Myoglobin scavenges ROS via its peroxidase activity, and binds to and inactivates NO in the heart and oxidative skeletal muscle. Myoglobin stores, buffers and facilitates intracellular oxygen diffusion, maintains aerobic metabolism under hypoxic/anoxic conditions, and provides oxygen supply support for mitochondria. Myoglobin alleviates oxidative stress, protects cardiac function and affects cardiac redox pathways. Myoglobin can be used in studies related to ischemia-reperfusion injury, oxidative stress-induced cardiac dysfunction and acute myocardial infarction.
Reactive Oxygen Species (ROS)   NO Synthase  
Ischemia-Reperfusion Injury   Myocardial Infarction  
/
HY-W012241 Dodecanedioic acid
Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
Endogenous Metabolite   PROTAC Linkers  
Glucose Metabolism  
/
HY-P99139 Anti-Mouse IL-1b Antibody (B122)
Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combined with Sulfasalazine (SAS) (HY-14655). Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for researches on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure.

Species: Mouse

Interleukin Related   Reactive Oxygen Species (ROS)   Ferroptosis  
Blood or Cardio-cerebrovascular Disease   Glioma  
/
HY-113371 2-Methylcitric acid
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W011412 TSTU
TSTU is used as a coupling reagent in peptide chemistry. TSTU can convert carboxylic acids into the corresponding N-hydroxysuccinimidyl (NHS) esters. TSTU can be applied to the attachment of labels to peptides, proteins, etc.
Biochemical Assay Reagents  
/
HY-Y0413 Biacetyl monoxime
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release.
Na+/K+ ATPase   Myosin  
Metabolic or Endocrine Disease   Cardiovascular Disease  
/
HY-D0843S N-Ethylmaleimide-d5
N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor.
Cathepsin   Deubiquitinase  
/
HY-P1928 Humanin
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging.
Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG.
Bcl-2 Family  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
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HY-D1711 MHI-148
MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and research. MHI-148 is immediately taken up and accumulated by lysosomes and mitochondria of tumor cells, but not in lysosomes and mitochondria of normal cells.
Fluorescent Dye  
Cancer  
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HY-P99956 Zilovertamab vedotin
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer.
Antibody-Drug Conjugates (ADCs)   Apoptosis  
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HY-126358 Acetylcarnitine
Acetylcarnitine is a CNS-penetrant endogenous metabolite. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Acetylcarnitine attenuates oxidative stress and neuroinflammation. Acetylcarnitine can be used for fatigue-associated diseases research. Acetylcarnitine can be used as a candidate diagnostic and prognostic biomarker of hepatocellular carcinoma.
Endogenous Metabolite   Mitochondrial Metabolism  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
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HY-P99386 Vesencumab
Vesencumab (MNRP-1685A) is IG1 antibody against neuropilin-1 (NRP-1). Vesencumab binds to NRP-1 and prevents the subsequent coupling of NRP-1 to VEGFR-2. Vesencumab has anti-angiogenic and anti-neoplastic activities. Vesencumab can be used in the research of metastatic solid tumors, including ovarian cancer.

Species: Human

Complement System   EGFR   PDGFR   p38 MAPK  
Cancer  
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HY-P991047 Anti-CD71/TfR1 Antibody
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Transferrin Receptor  
Cancer   Neurological, Eye or Ear Disease  
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HY-W011556 N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate
N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate (TCFH) is a powerful coupling and derivatizing reagent for ester prodrug synthesis. N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate can be used for antitumor drugs before medicine research.
Drug Isomer  
Cancer  
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HY-B1770 Sodium Iodide,99%
Sodium Iodide is a compound composed of sodium ions and iodine ions. Sodium Iodide scavenges hydrogen peroxide. Sodium Iodide maintains the level of thyroid hormone T3 through its iodine component. Sodium Iodide protects tissues from oxidative damage and regulates thyroid homeostasis. Sodium Iodide relieves acute myocardial infarction.
Environmental Pollutants   Biochemical Assay Reagents  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
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HY-41456 Ethyl 2-cyano-2-(hydroxyimino)acetate
Ethyl 2-cyano-2-(hydroxyimino) acetate (Oxyma) is a peptide coupling additive. Ethyl 2-cyano-2-(hydroxyimino) acetate suppresses racemization during peptide coupling and improves the coupling efficiency of both solution-phase and solid-phase peptide synthesis.
Biochemical Assay Reagents  
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HY-107754 Cesium chloride
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na+ transport produced by Alloxan. Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models.
Potassium Channel  
Cardiovascular Disease   Alzheimer's Disease  
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HY-21623 Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a common dichloromethane solvate of the palladium catalyst Pd(dppf)Cl2, a phosphine ligand palladium(II) complex, which can be used as a versatile precatalyst for various cross-coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can stabilize reaction intermediates and lower the reaction activation energy in coupling reactions, and can be used in Suzuki-Miyaura coupling reaction studies.
Biochemical Assay Reagents  
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HY-P703374 AIFM2 Protein, Human (Strep)
AIFM2 Protein, Human (Strep II) is the recombinant human-derived AIFM2, expressed by E. coli, with Strep II labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Oxidoreductases (EC 1)

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HY-P72094 ATP2A2 Protein, Human (His)
The ATP2A2 protein is a magnesium-dependent enzyme that hydrolyzes ATP and transfers calcium from the cytoplasm to the sarcoplasmic reticulum. It participates in autophagy during starvation and interacts with VMP1 to achieve ER isolating membrane contact. ATP2A2 Protein, Human (His) is the recombinant human-derived ATP2A2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

Enzymes & Regulators Translocases (EC 7)

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HY-P71469 Cardiac troponin I/Tnni3 Protein, Mouse (His-SUMO)
Cardiac troponin I, also known as Tnni3, plays a key role as an inhibitory subunit in the troponin complex, a key regulator of calcium sensitivity in actomyosin ATPase activity in striated muscle.Tnni3 interacts with TRIM63, emphasizing its involvement in complex cellular processes.Cardiac troponin I/Tnni3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Cardiac troponin I/Tnni3 protein, expressed by E.coli , with N-SUMO, N-6*His labeled tag.

Species: Mouse; Source: E. coli

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HY-P75961 PDE3A Protein, Human (sf9, His-GST)
PDE3A protein, a cyclic nucleotide phosphodiesterase, targets cAMP, cGMP, and cUMP, crucial in diverse physiological processes. In an E2/17beta-estradiol-induced pro-apoptotic pathway, E2 stabilizes the PDE3A/SLFN12 complex, leading to SLFN12 dephosphorylation and activating its pro-apoptotic ribonuclease activity. This pathway is implicated in tissues with high E2 concentrations, potentially contributing to processes like placenta remodeling. PDE3A Protein, Human (sf9, His-GST) is the recombinant human-derived PDE3A protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators

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HY-P73416 SMAC/Diablo Protein, Human (His)
SMAC/Diablo protein is a core participant in apoptosis and activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway. It antagonizes inhibitors of apoptosis proteins (IAPs), inhibits the binding of BIRC6/bruce to caspases and destabilizes XIAP/BIRC4. SMAC/Diablo Protein, Human (His) is the recombinant human-derived SMAC/Diablo protein, expressed by E. coli , with C-His labeled tag.

Species: Human; Source: E. coli

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HY-P701199 CSRP3 Protein, Human (HEK293, His)
CSRP3 Protein, Human (HEK293, His) is the recombinant human-derived CSRP3 protein, expressed by HEK293, with C-6*His tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors

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HY-P71372 Troponin C/TNNC1 Protein, Human (His, solution)
Troponin C, represented by the TNNC1 gene, centrally regulates striated muscle contraction. In the troponin complex consisting of Tn-I, Tn-T, and Tn-C, Tn-I inhibits the actomyosin ATPase, while Tn-T binds to tropomyosin. Troponin C/TNNC1 Protein, Human (His) is the recombinant human-derived Troponin C/TNNC1 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P71532 MYBPC3 Protein, Human (His-SUMO)
MYBPC3 Protein, positioned in the crossbridge region of vertebrate striated muscle A bands, binds to myosin heavy chain (MHC), F-actin, and native thin filaments, influencing actin-activated myosin ATPase. Its presence suggests potential modulation of muscle contraction, indicating a functional impact on the contractile apparatus, or a structural role in muscle fibers. MYBPC3 Protein, Human (His-SUMO) is the recombinant human-derived MYBPC3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P72275 Cardiac phospholamban/PLN, Human (P.pastoris, GST)
Cardiac phospholamban (PLN) strictly regulates ATP2A2 in the cardiac sarcoplasmic reticulum, reversibly inhibits ATPase activity and affects myocardial contractility. Modulation of PLN reduces the affinity of ATPase for Ca(2+), thereby affecting calcium reuptake during muscle relaxation and maintaining cardiac calcium homeostasis. Cardiac phospholamban/PLN, Human (P.pastoris, GST) is the recombinant human-derived Cardiac phospholamban/PLN, expressed by P. pastoris , with N-GST labeled tag.

Species: Human; Source: P. pastoris

Enzymes & Regulators

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HY-P71532A MYBPC3 Protein, Human (HEK293, His)
MYBPC3 Protein, positioned in the crossbridge region of vertebrate striated muscle A bands, binds to myosin heavy chain (MHC), F-actin, and native thin filaments, influencing actin-activated myosin ATPase. Its presence suggests potential modulation of muscle contraction, indicating a functional impact on the contractile apparatus, or a structural role in muscle fibers. MYBPC3 Protein, Human (HEK293, His) is the recombinant human-derived MYBPC3 protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P71367 TIM-16 Protein, S. cerevisiae
TIM-16 protein is an important component of the PAM complex, which uses ATP to promote the transfer of transit peptide-containing proteins from the inner membrane to the mitochondrial matrix. TIM-16 Protein, S. cerevisiae is the recombinant TIM-16 protein, expressed by E. coli , with tag free.

Species: Others; Source: E. coli

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HY-P7856 PDCD8/AIFM1 Protein, Human (His)
PDCD8/AIFM1 protein has the dual functions of NADH oxidoreductase and apoptosis regulator, and translocates from the mitochondrial intermembrane space to the cytoplasm and nucleus in response to apoptotic stimuli. It acts through a caspase-independent pathway, inducing “parthanatos” characterized by fragmentation of chromosomal DNA. PDCD8/AIFM1 Protein, Human (His) is the recombinant human-derived PDCD8/AIFM1 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P702438 SLC25A19 Protein, Human (Cell-Free, His)
SLC25A19, a pivotal mitochondrial transporter, facilitates thiamine diphosphate uptake into mitochondria. While the specifics of its antiporter activity regarding the influence of membrane potential or proton electrochemical gradient remain unclear, SLC25A19's role as a transporter underscores its importance in mitochondrial processes, particularly the transport of thiamine diphosphate, a vital coenzyme in various metabolic pathways. SLC25A19 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC25A19 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.

Species: Human; Source: E. coli Cell-free

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HY-P703646 Tnnt2 Protein, Mouse (His, Flag)
Tnnt2 Protein, Mouse (His, Flag) is the recombinant mouse-derived Tnnt2, expressed by E. coli , with C-6*His, C-Flag labeled tag. ,

Species: Mouse; Source: E. coli

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HY-P705691 Cardiac troponin I/Tnni3 Protein, Human (His)

Species: Human; Source: E. coli

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HY-P71372A Troponin C/TNNC1 Protein, Human (N-His)
Troponin C, represented by the TNNC1 gene, centrally regulates striated muscle contraction. In the troponin complex consisting of Tn-I, Tn-T, and Tn-C, Tn-I inhibits the actomyosin ATPase, while Tn-T binds to tropomyosin. Troponin C/TNNC1 Protein, Human (N-His) is the recombinant human-derived Troponin C/TNNC1 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P86432 Cardiac Troponin T Antibody (YA6124)
Cardiac Troponin T Antibody (YA6124) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin T.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81877 Phospholamban Antibody (YA1622)
Phospholamban Antibody (YA1622) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospholamban.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82974 Cardiac Troponin T Antibody (YA2719)
Cardiac Troponin T Antibody (YA2719) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin T.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86928 Junctophilin-2 Antibody (YA6621)
Junctophilin-2 Antibody (YA6621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Junctophilin-2.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81144 Cardiac Troponin I Antibody (YA3484)
Cardiac Troponin I Antibody (YA3484) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin I.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811586 Alpha-cardiac actin Antibody (YA10111)
Alpha-cardiac actin Antibody (YA10111) is a Mouse-derived and non-conjugated IgG1 recombinant monoclonal antibody, targeting to Alpha-cardiac actin.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81877A Phospholamban Antibody (YA1622)(PBS only)
Phospholamban Antibody (YA1622) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospholamban.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85398 Cardiac Troponin I Antibody (YA5090)
Cardiac Troponin I Antibody (YA5090) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cardiac Troponin I.

Host: Mouse; Reactivity: Human, Rat, Mouse

Monoclonal Antibodies Primary Antibodies

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HY-P85398A Cardiac Troponin I Antibody (YA5090)(PBS only)
Cardiac Troponin I Antibody (YA5090) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cardiac Troponin I.

Host: Mouse; Reactivity: Human, Rat, Mouse

Monoclonal Antibodies Primary Antibodies

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HY-P86427 Cardiac Troponin I Antibody (YA6119)
Cardiac Troponin I Antibody (YA6119) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cardiac Troponin I.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86834 Calsequestrin 2 Antibody (YA6527)
Calsequestrin 2 Antibody (YA6527) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calsequestrin 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-K0257 CM Agarose 6FF

MCE CM Agarose 6FF is a weak cation exchanger formed by covalently coupling carboxymethyl (CM) groups to agarose microspheres. It is suitable for both laboratory research and large-scale industrial purification processes.

Protein Biology Protein Purification Agarose Beads

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HY-K0258 SP Agarose 6FF

MCE SP Agarose 6FF is a strong cation exchanger formed by covalently coupling sulfopropyl (SP) groups to agarose microspheres. It is suitable for both laboratory research and large-scale industrial purification processes.

Protein Biology Protein Purification Agarose Beads

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HY-K0259 DEAE Agarose 6FF

MCE DEAE Agarose 6FF is a weak cation exchanger formed by covalently coupling diethylaminoethyl (DEAE) groups to agarose microspheres. It is suitable for both laboratory research and large-scale industrial purification processes.

Protein Biology Protein Purification Agarose Beads

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HY-K0260 Q Agarose 6FF

MCE Q Agarose 6FF is a strong cation exchanger formed by covalently coupling quarternary ammonium (Q) groups to agarose. It is suitable for both laboratory research and large-scale industrial purification processes.

Protein Biology Protein Purification Agarose Beads

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HY-K0264 Butyl Agarose 4FF

MCE Butyl Agarose 4FF is a hydrophobic chromatography medium formed by covalently coupling butyl ligands to agarose. It is suitable for both laboratory use and large-scale industrial purification.

Protein Biology Protein Purification Agarose Beads

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HY-K0265 Butyl Agarose HP

MCE Butyl Agarose HP is a high-resolution hydrophobic chromatography medium formed by covalently coupling butyl ligands to agarose. It is suitable for both laboratory use and large-scale industrial purification.

Protein Biology Protein Purification Agarose Beads

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HY-K0266 Octyl Agarose 6FF

MCE Octyl Agarose 6FF is a hydrophobic chromatography medium formed by covalently coupling butyl ligands to agarose. It is suitable for both laboratory use and large-scale industrial purification.

Protein Biology Protein Purification Agarose Beads

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HY-K0267 Octyl Agarose HP

MCE Octyl Agarose HP is a high-resolution hydrophobic chromatography medium formed by covalently coupling octyl ligands to agarose. It is suitable for both laboratory use and large-scale industrial purification.

Protein Biology Protein Purification Agarose Beads

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HY-K0270 Phenyl Agarose HP

MCE Phenyl Agarose HP is a high-resolution hydrophobic chromatography medium formed by covalently coupling phenyl ligands to agarose. It is suitable for laboratory-scale and industrial-scale purification of biomolecules.

Protein Biology Protein Purification Agarose Beads

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HY-K0272 ConA Agarose

MCE ConA agarose is prepared by covalently coupling ConA to agarose and is widely used for the separation and purification of glycoproteins, membrane proteins, glycolipids, polysaccharides, membrane vesicles containing mannose or glucose residues, IgM, and lipoprotein hormones.

Protein Biology Protein Purification Agarose Beads

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HY-K6303 Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit

MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

Cell Biology 3D Cell Culture PSC Induction Product Series

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HY-KD1030 Tubulin Deep Red Kit

Tubulin Deep Red is a fluorescent probe with red fluorescence that can specifically label microtubules in living mammalian cells.

Cell Biology Cell Analysis Organelle Research

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Keywords

mechano-energetic uncoupling | heart failure | cardiac energetics | excitation-contraction coupling | mitochondria | microtubules | junctophilin-2 | myocardial fatigue