CAMP - cathelicidin antimicrobial peptide Gene
Also Known as LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39
Species: Homo sapiens
About CAMP
This gene has 2 transcripts (splice variants) and 249 orthologues. Restricted expression toward bone marrow (RPKM 591.5).
Summary
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The protein plays an important role in innate immunity defense against viruses. In addition to its Antibacterial, Antifungal, and Antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2021]
CAMP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004345.5 | NP_004336.4 | cathelicidin antimicrobial peptide preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
31818937 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
12759353 | GOA |
| located in specific granule |
IDA
IDA: Inferred from direct assay
|
12759353 | GOA |
CAMP Protein Structure
Cathelicidins: Cathelicidin (33 - 98)
CAP18_C: LPS binding domain of CAP18 (C terminal) (136 - 163)
- 0
- 100
- 170 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cathelicidin antimicrobial peptide |
|
CAMP Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82635 | Cathelicidin Antibody (YA2380) | WB, IHC-P, IP | Human |
| HY-P82635A | Cathelicidin Antibody (YA2380)(PBS only) | WB, IHC-P, IP | Human |
| HY-P85074 | Cathelicidin Antibody (YA4766) | ELISA | Species independent |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Rosacea |
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| Cellulitis |
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| Facial Dermatosis |
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| Mycobacterium Marinum |
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| Bacterial Infectious Disease |
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| Severe Congenital Neutropenia 3 |
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| Hidradenitis Suppurativa |
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| Hidradenitis |
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| Cystic Fibrosis |
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| Dermatitis, Atopic |
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| Psoriasis |
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| Necrotizing Fasciitis |
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| Coffin-Lowry Syndrome |
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| Skin Disease |
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| Disease By Infectious Agent |
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| Papillon-Lefevre Syndrome |
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| Toxic Shock Syndrome |
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| Eczema Herpeticum |
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| Denture Stomatitis |
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Impetigo |
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| Polycystic Kidney Disease |
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| Sebaceous Gland Disease |
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| Vaginal Disease |
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| Shigellosis |
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| Mycobacterium Tuberculosis 1 |
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| Contact Dermatitis |
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| Chancroid |
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| Vaginitis |
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| Fallopian Tube Disease |
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| Tinea Pedis |
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| Dermatophytosis |
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| Allergic Contact Dermatitis |
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| Endocardium Disease |
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| Colorectal Cancer |
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| Urethritis |
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| Gingival Disease |
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| Asthma |
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| Telangiectasis |
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| Urinary Tract Infection |
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| Severe Congenital Neutropenia |
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| Scleredema Adultorum |
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| Integumentary System Disease |
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| Inflammatory Bowel Disease |
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| Primary Bacterial Infectious Disease |
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| Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease |
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| Acute Promyelocytic Leukemia |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | CAMP | VGNC | VGNC:60340 |
| Mus musculus | CAMP | MGD | MGI:108443 |
| Canis familiaris | CAMP | VGNC | VGNC:38688 |
| Macaca mulatta | CAMP | VGNC | VGNC:84221 |
| Rattus norvegicus | CAMP | RGD | RGD:1559878 |
| Others | CAMP | NCBI |