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Glucocorticoid Oscillatory Rhythms in Stress Environments

Cellular Stress Chronic Inflammation Metabolic Diseases Sleep Deprivation

Glucocorticoid oscillatory rhythms describe the temporally structured secretion of cortisol in humans and corticosterone in rodents by the hypothalamic-pituitary-adrenal (HPA) axis, in which a circadian profile is constructed from recurring ultradian pulses whose amplitudes vary across the day. Acute stress raises glucocorticoid output while preserving pulsatility, whereas prolonged stress can alter hypothalamic drive, adrenal responsiveness, and hormone dynamics. Research has therefore moved beyond measurements of mean cortisol concentration toward the recognition that pulse timing, amplitude, and frequency carry biologically relevant information. Mechanistic and clinical studies now place glucocorticoid rhythmicity at the intersection of stress adaptation, neuroendocrine homeostasis, gene regulation, metabolism, cognition, and glucocorticoid pharmacology[1][2][3].

The oscillations arise from dynamic feedforward and negative-feedback interactions within the HPA axis rather than requiring a pulsatile hypothalamic generator: constant corticotropin-releasing hormone stimulation can drive physiological-frequency ACTH and glucocorticoid oscillations through a pituitary-adrenal peripheral network, while excessive CRH disrupts this oscillatory response. Target cells decode these endocrine pulses principally through the glucocorticoid receptor (GR). Ultradian hormone stimulation produces cyclic GR occupancy at regulatory elements, rapid receptor exchange and recycling through molecular chaperone machinery, and discrete bursts of nascent transcription rather than the transcriptional program generated by continuous hormone exposure. HSP90-dependent GR cycling coordinates transient CBP/p300 recruitment, histone H4 acetylation, RNA polymerase II recruitment, and pulsatile transcription of targets such as PER1. At the genomic level, pulsatile and constant stimulation also generate distinct patterns of chromatin accessibility and long-range regulatory interactions, showing that hormone temporal structure can determine transcriptional output independently of cumulative exposure alone[2][4][5][6].

These mechanisms are directly relevant to stress-related disease and glucocorticoid therapy. In healthy volunteers whose endogenous cortisol synthesis was suppressed and replaced experimentally, maintaining or removing physiological ultradian rhythmicity altered morning vigour, fatigue, concentration, diurnal mood variation, and functional connectivity within large-scale brain networks, providing human evidence that cortisol pulsatility influences neuropsychological function. The translational importance is particularly apparent in adrenal insufficiency, where conventional replacement does not reproduce natural glucocorticoid dynamics. In the PULSES trial, pulsatile subcutaneous hydrocortisone replacement was well tolerated and produced subjective improvements in fatigue and mood together with differential neural processing in glucocorticoid-sensitive brain regions, although the prespecified facial-expression recognition endpoint did not improve. These observations support investigation of physiological hormone-pattern replacement rather than treatment strategies based only on total daily glucocorticoid dose[7][8][3].

Major gaps persist in translating cellular and animal observations into clinically actionable temporal endocrinology. The transcriptional consequences of glucocorticoid pulses are strongly dependent on chromatin context and treatment pattern, while available human trials remain small and do not yet establish whether restoring ultradian dynamics improves long-term clinical outcomes. It is also unresolved which pulse characteristics—frequency, amplitude, phase, or recovery interval—are most important for particular tissues and diseases, and how stress-induced remodeling of HPA-axis dynamics interacts with these tissue-specific decoding mechanisms. Future research therefore needs high-frequency hormone measurements linked to molecular, neural, metabolic, and clinical endpoints, together with larger trials comparing physiological pulsatile replacement against conventional administration. Such work could determine whether chronotherapy that reconstructs both circadian and ultradian glucocorticoid signals can preserve GR responsiveness while reducing consequences associated with nonphysiological continuous or long-acting exposure[6][7][8][3].

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Cat. No. Product Name Information Application Publication
HY-10256 Adezmapimod
Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.
Organoid   p38 MAPK   Autophagy   Mitophagy   HSP  
Lung Cancer   Prostate Cancer   Gastric Cancer   Ovarian Cancer   Neurodegenerative Disease   Depression   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
639
HY-14648 Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.
Exosomes   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic   ADC Payloads  
Metabolic or Endocrine Disease   Prostate Cancer   Pancreatic Cancer   Viral Infection   Bacterial Infection   Fungal Infection   Pain   Autoimmune Disease   Digestive System Inflammation   Cardiovascular Disease   Non-Small Cell Lung Cancer   Lung Squamous Cell Carcinoma   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
402
HY-13757 Tamoxifen Citrate
Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice.
Estrogen Receptor/ERR   HSP   Autophagy   Apoptosis  
Neurological, Eye or Ear Disease   Digestive System Disease   Prostate Cancer   Viral Infection   Digestive System Inflammation   Luminal Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
270
HY-13757A Tamoxifen
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).
Estrogen Receptor/ERR   HSP   Autophagy   Apoptosis  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease   Digestive System Disease   Prostate Cancer   Viral Infection   Digestive System Inflammation   Luminal Breast Cancer   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
270
HY-13433 Thapsigargin
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.
Calcium Channel   SARS-CoV   Apoptosis  
Cancer   Infection  
158
HY-K0510A RT Master Mix for qPCR II

MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription. With advanced reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Molecular Biology RT-PCR Reverse transcription PCR

155
HY-N0830B Palmitic acid sodium
Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

Source: Widespread

Environmental Pollutants   HSP   Endogenous Metabolite  
Cancer  
122
HY-N0830 Palmitic acid
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.

Source: Widespread

Environmental Pollutants   HSP   Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
122
HY-N0583 Hydrocortisone
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Environmental Pollutants   Glucocorticoid Receptor   Endogenous Metabolite  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Pain   Immunosuppression  
92
HY-L014 NF-κB Signaling Compound Library
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,801 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

85
HY-L024 Histone Modification Research Compound Library
A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases. MCE owns a unique collection of 931 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Signaling Pathway Targeting Libraries

85
HY-L042 Glycoside Compound Library
Glycosides are compounds in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Many biologically active compounds are glycosides. Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids, antibiotics, etc. The glycosidic residue can be crucial for their activity or can only improve pharmacokinetic parameters. Glycosides, which exhibit anti-inflammatory, anti-infection, anti-cancer and anti-oxidative properties, play numerous important roles in living organisms, such as streptomycin, as an aminoglycoside antibiotic, has anti-infection activity. Anthracyclines possess good antibacterial and anti-cancer activities. MCE Glycoside Compound Library contains a unique collection of 921 glycoside compounds and is a useful tool to discovery glycoside drugs.

Structure Classified Libraries

85
HY-L054 Endoplasmic Reticulum Stress Compound Library
Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer. MCE Endoplasmic Reticulum Stress Compound Library contains 379 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

Signaling Pathway Targeting Libraries

85
HY-L039 Reprogramming Compound Library
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 3,231 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Signaling Pathway Targeting Libraries

83
HY-L045 Oxygen Sensing Compound Library
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 4,317 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Signaling Pathway Targeting Libraries

83
HY-L047 Endocrinology Compound Library
The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function. The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease. MCE offers a unique collection of 908 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Disease Focused Libraries

83
HY-L074 Anti-Breast Cancer Compound Library
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 3,404 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Disease Focused Libraries

83
HY-L088 Angiogenesis-Related Compound Library
Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer). MCE offers a unique collection of 3,660 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

Signaling Pathway Targeting Libraries

83
HY-L090 Transcription Factor-Targeted Library
Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential. MCE offers a unique collection of 2,569 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Signaling Pathway Targeting Libraries

83
HY-L126 Nuclear Receptor Compound Library
Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes. Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors. MCE supplies a unique collection of 1,092 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

Signaling Pathway Targeting Libraries

83
HY-L131 Osteogenesis Compound Library
Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health. Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Osteoblast formation and bone formation are regulated by hormones, growth factors, cytokines, etc. MCE offers a unique collection of 984 bone formation compounds with identified and potential inducing osteogenesis activity. MCE bone formation compound library is a useful tool for the study of bone disease drugs and pharmacology.

Signaling Pathway Targeting Libraries

83
HY-L165 Dopamine Receptor Compound Library
Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life. MCE designs a unique collection of 282 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Signaling Pathway Targeting Libraries

83
HY-L185 Anti-Fibrosis Compound Library
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 2,568 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Disease Focused Libraries

83
HY-L191 Tibetan Medicine Compound Library
Tibetan medicine, as one of the treasures of traditional Chinese medicine, carries the profound cultural heritage of the Tibetan people and their unique understanding of health. Tibet is the birthplace of Tibetan medicine, and its plateau climate and unique ecological environment have nurtured its rich medicinal resources. Among them, cordyceps, saffron and snow lily are favored by people for their excellent medicinal value and unique growth characteristics. Tibetan medicine, with its profound heritage, plays a crucial role in the management of diseases that are unique to high-altitude regions, such as altitude stress. It facilitates a swifter adaptation to high-altitude conditions and mitigates the symptoms of altitude sickness by meticulously recalibrating the internal environment within the human body. For rheumatic diseases, cardiovascular diseases, etc., Tibetan medicine has also shown its remarkable effect. MCE included 1,146 natural products from Tibetan medicine, including animal, plant and mineral sources.
83
HY-L211 Human Hormone Compound Library
Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases. MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.
83
HY-L218 Animal Drug Library
Animal drug (also veterinary drug) refers to a drug intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in animals. Animal Drugs @ FDA is a searchable online database that includes most FDA-approved and conditionally approved animal drugs. The major classes of veterinary drugs include antibiotics, anthelmintics, coccidiostats, nonsteroidal anti-inflammatory drugs, sedatives, corticosteroids, beta-agonists, and anabolic hormones. MCE has collected 166 FDA-approved veterinary drug compounds for use in scientific research.
83
HY-L228 Lipid Metabolite Compound Library
Lipids are important energy storage substances in the human body. They are involved in the regulation of cell structure and function, as well as signaling pathways and gene expression. Abnormal lipid levels in tissues or their dysregulation can lead to various diseases. These include obesity, type 2 diabetes, non-alcoholic fatty liver disease, neurodegenerative diseases, infections, and cancer. Therefore, maintaining normal levels of lipid metabolism is critical to overall health. One of the key features of cancer is aberrant lipid metabolism. This includes alterations in lipid uptake, lipid desaturation, neolipogenesis, lipid droplets, and fatty acid oxidation in cancer cells. These changes all contribute to cellular survival in an ever-changing microenvironment. They do this by modulating feed-forward oncogenic signals and key oncogenic functions. Additionally, they affect oxidative stress, other types of stress, immune responses, and intercellular communication. Alterations in lipid metabolism have a strong impact on the properties of cancer stem cells. This includes aspects such as self-renewal, differentiation, invasion, metastasis, drug sensitivity, and resistance. Furthermore, these alterations also modulate T cell responses. MCE can offer 146 metabolites of lipid metabolism pathways, which can be used for drug screening in cancer, immune-based diseases, metabolic diseases, and other diseases.

Metabolism Focused Libraries

83
HY-L234 Nucleotide Metabolite Compound Library
Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs. MCE can provide 83 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.

Metabolism Focused Libraries

83
HY-L239 Steroid Hormones Library
Steroid hormones (also known as steroidal hormones) are a class of tetracyclic aliphatic hydrocarbon compounds derived from cholesterol. Typical representatives of steroid hormones include cortisol, aldosterone, testosterone, estradiol, among others. These hormones serve diverse regulatory functions within the body. For instance, aldosterone helps maintain the homeostasis of extracellular fluid volume and circulating blood volume; testosterone and estradiol primarily promote the development and maturation of male and female reproductive organs and regulate reproductive functions. MCE designs a unique collection of 71 steroid hormones. This library can be used for research related to metabolic or immune diseases, investigations into the mechanisms of action of nuclear receptor signaling pathways, as well as identification and quantitative analysis in metabolomics studies.

Compound Characteristic Classified Libraries

83
HY-L240 Plant Hormone Library
Plant hormones are natural signaling molecules synthesized by plants themselves, serving as crucial chemical messengers that exert physiological effects on plants at extremely low concentrations. They coordinate cellular growth, division, differentiation, and organ formation, helping plants adapt to environmental changes. Major categories include abscisic acid, auxins, gibberellins, cytokinins, ethylene, and brassinosteroids, among others. MCE has included 44 plant hormones, which can be used for identification in plant metabolomics and related botanical research.

Compound Characteristic Classified Libraries

83
HY-L244 High-Efficiency Gene Editing Compound Library
In this era of rapid advancement in gene-editing technology, the CRISPR-Cas system, with its powerful programmability, is leading a transformation in life sciences research. It enables efficient and precise targeted modification of an organism's genome, providing a robust tool for studying gene function, treating genetic diseases, and improving crop varieties. However, bottlenecks such as insufficient editing efficiency, low homologous directed repair efficiency, and potential off-target risks remain major challenges in achieving precise genetic modifications and developing gene therapies. To overcome these limitations, the MCE High-Efficiency Gene Editing Compound Library systematically includes 761 small molecules that are known or have the potential to enhance gene-editing efficiency. These compounds work by targeting and modulating the DNA damage repair network, mechanistically inhibiting non-homologous end joining, promoting homologous directed repair, or regulating chromatin states and cellular responses, thereby significantly optimizing editing outcomes. This library is suitable for developing "CRISPR-small molecule" combination therapy strategies, improving gene-editing efficiency, and providing a powerful tool for in-depth research into the mechanisms of DNA damage repair in gene editing.

Signaling Pathway Targeting Libraries

83
HY-L265 Cholesterol Metabolism Compound Library
Cholesterol is a crucial lipid that maintains cell membrane structure, serves as a precursor for the synthesis of steroid hormones and bile acids, and plays an important role in cell signal transduction and membrane function regulation. Intracellular cholesterol levels are precisely controlled by multiple processes, including synthesis, uptake, transport, esterification, storage, and efflux. Dysregulation of cholesterol metabolism is closely associated with diseases such as atherosclerosis, fatty liver disease, metabolic syndrome, and various cancers. The Cholesterol Metabolism Compound Library contains 558 compounds and focuses on cholesterol metabolism and homeostatic regulation. It provides an efficient tool for mechanistic studies of cholesterol metabolism and for drug discovery in metabolism‑related diseases.
83
HY-L923 Ion Channel Lead-like Compound Library
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields. MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Focused and target libraries

83
HY-13683 Mifepristone
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
Endogenous Metabolite   Progesterone Receptor   Glucocorticoid Receptor   NO Synthase   Autophagy  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Viral Infection   Depression   Pain  
80
HY-107202 Polyinosinic-polycytidylic acid
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Digestive System Disease   Prostate Cancer   Pain   Digestive System Inflammation   Lung Fibrosis   Rheumatoid Arthritis  
73
HY-10211 Tanespimycin
Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.
HSP   Autophagy   Mitophagy   Bacterial   Apoptosis   Antibiotic  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Bacterial Infection   Digestive System Inflammation  
71
HY-B1618 Corticosterone
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Glucocorticoid Receptor   Endogenous Metabolite   iGluR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   SARS-CoV-2 Infection   Osteoarthritis  
71
HY-B0389 D-Glucose
D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.
Environmental Pollutants   Endogenous Metabolite  
Bacterial Infection   Cardiovascular Disease   Triple-Negative Breast Cancer   Metastatic Breast Cancer   Type 1 Diabetes   Type 2 Diabetes  
63
HY-10941 VER-155008
VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
HSP   Autophagy  
Cancer   Neurological, Eye or Ear Disease  
52
HY-A0070C Liothyronine hydrochloride
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
46
HY-A0070B Liothyronine sodium hydrate
Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
46
HY-A0070 Liothyronine sodium
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation   SARS-CoV-2 Infection  
46
HY-A0070A Liothyronine
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR.
Thyroid Hormone Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
46
HY-K0511A RT Master Mix for qPCR II (gDNA digester plus)

MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. With updated reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically. The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Molecular Biology RT-PCR Reverse transcription PCR

45
HY-15230 Geldanamycin
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

Source: Streptomyces hygroscopicus

HSP   Bacterial   Influenza Virus   Antibiotic  
Inflammation or Immune System Disease   Prostate Cancer   Viral Infection   Bacterial Infection  
44
HY-N0293 Paeoniflorin
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.
HSP  
Cancer   Infection   Parkinson's Disease  
43
HY-K0511 RT Master Mix for qPCR (gDNA digester plus)

MCE RT Master Mix for qPCR (gDNA digester plus) is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. The cDNA product can be directly applied as a template in a standard PCR and real time quantitative PCR (qPCR). The 100 rxns is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Molecular Biology RT-PCR Reverse transcription PCR

40
HY-12495A ISRIB
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.
Biochemical Assay Reagents   Eukaryotic Initiation Factor (eIF)  
Neurological, Eye or Ear Disease  
37
HY-B0469 Medroxyprogesterone acetate
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
Progesterone Receptor   Androgen Receptor   Glucocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
35
HY-17571 Oxytocin
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.

Source: the paraventricular and supraoptic nuclei of the hypothalamus

Oxytocin Receptor   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease   Viral Infection  
30
HY-18569 3-Indoleacetic acid
3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis.
Environmental Pollutants   Endogenous Metabolite  
Metabolic or Endocrine Disease  
25
HY-P0252 α-MSH
α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).
Melanocortin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
24
HY-B0214 Prednisone
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
Glucocorticoid Receptor   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Prostate Cancer   Viral Infection   Pain   Digestive System Inflammation   Cardiovascular Disease   Lung Fibrosis  
22
HY-B0260 Methylprednisolone
Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
Glucocorticoid Receptor   Autophagy   SARS-CoV   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Viral Infection   Coronavirus Infection   Bacterial Infection   Depression   Pain   Cardiovascular Disease   Non-Small Cell Lung Cancer  
21
HY-N0637 Eriodictyol
Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases.
Melanocortin Receptor   TRP Channel  
Cancer   Inflammation or Immune System Disease   Viral Infection   Obesity   Lung Fibrosis  
16
HY-B1829A Dexamethasone phosphate disodium
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).
Glucocorticoid Receptor   TGF-β Receptor   Interleukin Related  
Neurological, Eye or Ear Disease   Ulcerative Colitis  
13
HY-17463 Prednisolone
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Prostate Cancer   Viral Infection   Pain   Lung Fibrosis  
12
HY-P0059 Teriparatide
Teriparatide (Human parathyroid hormone-(1-34)) is a PTH1 receptor agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research.
PTHR   Thyroid Hormone Receptor  
Cancer  
12
HY-111372 Finerenone
Finerenone (BAY 94-8862) is a third-generation, selective, and orally active nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (> 500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Mineralocorticoid Receptor  
Cardiovascular Disease   Glucose Metabolism  
9
HY-103377 Antalarmin hydrochloride
Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.
CRFR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
8
HY-B0251 Eplerenone
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV).
Mineralocorticoid Receptor   Endogenous Metabolite  
Breast Cancer   Bacterial Infection   Atherosclerosis   Hypertension   Myocardial Infarction   Heart Failure   Type 2 Diabetes   Insulin Resistance   Obesity   Hyperthyroidism   Chronic Kidney Disease  
8
HY-P3465 Bulevirtide
Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research.
HBV  
Viral Infection  
8
HY-19870 Setmelanotide
Setmelanotide (RM-493) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide activates the CaMKK2/AMPK signaling pathway. Setmelanotide mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.
Melanocortin Receptor   Calmodulin   AMPK  
Blood or Cardio-cerebrovascular Disease   Respiratory Disease   Obesity   Fatty Liver Disease  
8
HY-14127 R121919
R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.
CRFR  
Metabolic or Endocrine Disease   Depression  
7
HY-B0561 Spironolactone
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca2+ channels to exert antihypertensive effects.
Mineralocorticoid Receptor   Androgen Receptor   Autophagy   Calcium Channel  
Prostate Cancer   Viral Infection   Glucose Metabolism   Parkinson's Disease   Hypertension  
7
HY-13580 Budesonide
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.
Glucocorticoid Receptor   ADC Payloads  
Cancer   Inflammation or Immune System Disease   Viral Infection   Pain  
7
HY-17461 Cortisone
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Pain   Cardiovascular Disease   Glucose Metabolism   SARS-CoV-2 Infection   Osteoarthritis  
6
HY-N6947 Lutein
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

Source: egg's yolk

Endogenous Metabolite   Apoptosis   Reactive Oxygen Species (ROS)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
6
HY-77839 Cortodoxone
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease  
5
HY-113414 Deoxycorticosterone
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM. Deoxycorticosterone could acts as an immune stimulator in fish.
Endogenous Metabolite   Mineralocorticoid Receptor  
Inflammation or Immune System Disease  
5
HY-112173 Prolylleucine
Prolylleucine (Z-Pro-D-Leu) is a dipeptide containing branched-chain amino acids. Prolylleucine (Z-Pro-D-Leu) can affect the circadian rhythms and behaviour of animals.
Others  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-P0002 Protirelin
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
Thyroid Hormone Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
4
HY-B1422 9-Aminoacridine
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections.
Bacterial   HIV  
Cancer   Klebsiella Pneumoniae Infection  
4
HY-N0743 Senkyunolide A
Senkyunolide A is a phthalide, anti-tumor cell proliferation agent with anticancer activity. Senkyunolide A protects neurons from corticosterone (HY-B1618)-induced apoptosis by decreasing protein phosphatase PP2A and α-synuclein phosphorylation and protein level. Senkyunolide A also inhibits osteoarthritis through the NLRP3 signaling pathway and suppresses the expression of CD137, a diagnostic biomarker for atherosclerosis.
α-synuclein  
Cancer   Inflammation or Immune System Disease   Depression   Parkinson's Disease  
4
HY-16276 Osilodrostat
Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS).
Mineralocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Cardiovascular Disease   SARS-CoV-2 Infection  
4
HY-P72238 HSP90AA1 Protein, Human (His-SUMO)
The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Species: Human; Source: E. coli

4
HY-K0512 microRNA RT Master Mix for qPCR Ⅲ (poly A)

MCE microRNA RT Master Mix for qPCR Ⅲ (poly A) uses poly(A)-tailing method to perform reverse transcription from miRNA first-strand to cDNA.

Molecular Biology RT-PCR Reverse transcription PCR

4
HY-N1073 Wighteone
Wighteone (6-Isopentenylgenistein; Erythrinin B) is a prenylated isoflavone that acts as a HSP90/EGFRL858R/T790M inhibitor and antifungal agent. Wighteone reduces the expression level of HSP90, blocks EGF-induced phosphorylation of EGFR, and thereby inhibits the downstream ERK and AKT signaling pathways. Wighteone induces cell cycle redistribution, inhibits proliferation and triggers apoptosis in cancer cells. Wighteone can be isolated from Erythrina suberosa, and can also be induced to synthesize in Lotus japonicus under specific conditions. Wighteone can be used to study HER2-positive breast cancer, leukemia, non-small cell lung cancer with EGFRL858R/T790M mutation, and fungal infections.
Apoptosis   EGFR   HSP   ERK   Akt  
Leukemia/Lymphoma/Myeloma   Fungal Infection   Non-Small Cell Lung Cancer   HER2-Positive Gastric Cancer  
3
HY-P0257 Astressin
Astressin is a potent corticotropin releasing factor (CRF) antagonist.
CRFR  
Neurological, Eye or Ear Disease  
3
HY-135542 NBI-27914
NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor.
CRFR  
3
HY-P0086 Corticotropin-releasing factor (human)
Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
CRFR  
Neurological, Eye or Ear Disease  
3
HY-17461A Cortisone acetate
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
3
HY-P2293 Luteinizing hormone (human)
Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction.
GnRH Receptor  
Metabolic or Endocrine Disease  
3
HY-P0227 SHU 9119
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.
Melanocortin Receptor  
Metabolic or Endocrine Disease  
3
HY-113447 11-Dehydrocorticosterone
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Cardiovascular Disease  
2
HY-B1438 Canrenone
Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
Mineralocorticoid Receptor  
Cardiovascular Disease  
2
HY-P0009A Cetrorelix acetate
Cetrorelix (SB-75) acetate is a competitive gonadotropin-releasing hormone receptor (GnRHR) antagonist with a Kd of 0.19 nM. Cetrorelix acetate inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby suppressing the secretion of downstream sex steroids. Cetrorelix acetate prevents ovulation, induces reversible reproductive shutdown and azoospermia, reduces ovarian fibrosis, improves superovulation outcomes, and inhibits chemotherapy-induced mitochondria-dependent apoptosis. Cetrorelix acetate is applicable for fertility assistance research.
GnRH Receptor   Apoptosis  
Female Reproductive System Disease  
2
HY-B1472 Deoxycorticosterone acetate
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria.
Mineralocorticoid Receptor  
Metabolic or Endocrine Disease   Hypertension  
2
HY-P70261 GH/Somatotropin Protein, Mouse
GH/Somatotropin Protein, Mouse is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the growth disorders research.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Peptide Hormone & Neuropeptides Growth Hormone/Somatotropin

2
HY-P1750 Shepherdin (79-87)
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.
HSP   Survivin  
Cancer  
1
HY-P3641 Kisspeptin 13
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
GnRH Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-W127601 Lard oil
Lard oil is an orally active biochemical reagent. Lard oil upregulates PERK, eIF2a, CHOP, OPN, TLR2, TLR4, TNF-α, and downregulates GRP78 and IRE1a. Lard oil induces responses such as body fat accumulation, elevated serum insulin levels, increased HOMA-IR, hepatic ectopic lipid deposition, hepatic endoplasmic reticulum stress, and hepatic inflammation. Lard oil can be used in studies related to diet-induced obesity, insulin resistance, and non-alcoholic fatty liver disease.
Biochemical Assay Reagents   PERK   Eukaryotic Initiation Factor (eIF)   Toll-like Receptor (TLR)   TNF Receptor   IRE1  
Insulin Resistance   Obesity  
1
HY-141567 Pseudouridine 5'-triphosphate
Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection.
DNA/RNA Synthesis  
Viral Infection  
1
HY-N3417 Kongensin A
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.
HSP   RIP kinase   Apoptosis   Necroptosis  
Inflammation or Immune System Disease  
1
HY-NP181 Testosterone/BSA
Testosterone/BSA, a conjugate of Testosterone (HY-113415) and bovine serum albumin (BSA), acts as a nuclear transporter and cytoplasmic accumulator. Testosterone/BSA can enter the nuclei of rat testicular spermatocytes, spermatids and rat liver endothelial cells, while the antigenicity of BSA remains intact. Testosterone/BSA accumulates in the cytoplasm of rat hepatocytes in granular form. Testosterone/BSA can be used to investigate the membrane-initiated or non-genomic activities of steroid hormones.
Biochemical Assay Reagents  
1
HY-113422S Tetrahydrocorticosterone-d5
Tetrahydrocorticosterone-d5 is the d5-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
1
HY-126030 (+)-Syringaresinol
(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia.
Nuclear Factor of activated T Cells (NFAT)  
Cancer  
1
HY-P1750A Shepherdin (79-87) TFA
Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity.
HSP   Survivin  
Cancer  
1
HY-N8460A Cortisol sulfate sodium
Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate sodium is a specific ligand for intracellular transcortin.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-N1455 Falcarinol
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis. Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
HSP   Apoptosis  
1
HY-N3297 Meranzin hydrate
Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
mTOR   GHSR  
Depression  
1
HY-W338584 Hydroxycitric acid tripotassium
Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation.
Keap1-Nrf2   Ferroptosis   Apoptosis   mTOR   NF-κB   ATP Citrate Lyase   AMPK   Ribosomal S6 Kinase (RSK)   DNA/RNA Synthesis  
Leukemia/Lymphoma/Myeloma   Pulmonary Hypertension   Kidney Stones   Prostatic Hyperplasia  
1
HY-P3641A Kisspeptin 13 TFA
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
GnRH Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-P2203 SAHM1
SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice.
Notch  
Inflammation or Immune System Disease  
1
HY-N0008 Orcinol glucoside
Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases.
Wnt   p38 MAPK   mTOR   Keap1-Nrf2   TGF-β Receptor  
Depression   Obesity  
1
HY-113440 5-Methoxytryptophol
5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism.
Melatonin Receptor   ERK   TNF Receptor   Interleukin Related   MMP   Endogenous Metabolite  
Digestive System Disease   Sleep-Wake Disorder   Periodontal Disease   Osteoporosis  
1
HY-A0070AG Liothyronine (GMP)
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor  
Cancer   Metabolic or Endocrine Disease  
1
HY-P99812 Ragifilimab
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab binds to and activates GITR on T cells, which stimulates the immune system to enhance its anti-tumor activity. Ragifilimab can be used for advanced or metastatic solid tumors research.

Species: Human

TNF Receptor  
Cancer   Inflammation or Immune System Disease  
1
HY-133705 Geldanamycin-FITC
Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm).
HSP  
1
HY-Z0478 (-)-Limonene
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture.
Bacterial   Antibiotic   CaMK  
Metabolic or Endocrine Disease   Bacterial Infection   Cardiovascular Disease   Parkinson's Disease  
1
HY-N0910 Notoginsenoside Ft1
Notoginsenoside Ft1 is an orally active bioactive saponin. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8+ T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca2+ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y12 receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an FXR antagonist to combat obesity and insulin resistance.
PI3K   mTOR   Akt   Apoptosis   p38 MAPK   ERK   Transmembrane Glycoprotein   Glutathione Reductase (GR)   Estrogen Receptor/ERR   Calcium Channel   Ferroptosis   G protein-coupled Bile Acid Receptor 1   FXR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Neurodegenerative Disease   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-B1183 Hydrocortisone acetate
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
1
HY-P2543 Neuropeptide Y (3-36) (human, rat)
Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides[1].
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
1
HY-P1108A Astressin 2B TFA
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2.
CRFR  
Digestive System Disease   Anxiety or Fear-Related Disease   Digestive System Inflammation  
1
HY-106373A Adrenocorticotropic hormone TFA
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone TFA stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone TFA regulates cortisol and androgen production. Adrenocorticotropic hormone TFA can promote the development of spermatogenesis. Adrenocorticotropic hormone TFA can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone TFA can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome.
Androgen Receptor   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease   Gout  
1
HY-B0389R D-Glucose (Standard)
D-Glucose (Standard) is the analytical standard of D-Glucose. This product is intended for research and analytical applications. D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.
Reference Standards   Endogenous Metabolite  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
1
HY-B1618S Corticosterone-d8
Corticosterone-d8 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-141567A Pseudouridine 5'-triphosphate trisodium solution (100 mM)
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection.
DNA/RNA Synthesis  
Viral Infection  
1
HY-P99688 Latozinemab
Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research.

Species: Human

Neurotensin Receptor  
Cancer   Neurological, Eye or Ear Disease  
1
HY-B0167S Salicylic acid-d6
Salicylic acid-d6 is a deuterium labeled Salicylic acid (HY-B0167). Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
Isotope-Labeled Compounds   COX   Autophagy   Mitophagy   Apoptosis  
Cancer   Inflammation or Immune System Disease  
1
HY-B0389S10 D-Glucose-13C
D-Glucose-13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-106373 Adrenocorticotropic hormone
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone regulates cortisol and androgen production. Adrenocorticotropic hormone can promote the development of spermatogenesis. Adrenocorticotropic hormone can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome.
Androgen Receptor   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease   Gout  
1
HY-18678A Bremelanotide Acetate
Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders.
Melanocortin Receptor  
Metabolic or Endocrine Disease  
1
HY-128730 Acetyl phosphate lithium potassium
Acetyl phosphate lithium potassium is an endogenous metabolic product. Acetyl phosphate lithium potassium is a key substance in bacterial metabolic regulation, particularly in Lysine acetylation, and plays an important role in bacterial responses to environmental stress and adaptive reactions.
Endogenous Metabolite   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
1
HY-10624 THIQ
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants.
Melanocortin Receptor  
Obesity  
1
HY-129038 GR24
(Rac)-GR24 (Strigolactone GR24) is a plant hormone analog. (Rac)-GR24 can mimic the natural germination stimulus of parasitic plant seeds, promoting seed germination in the absence of host plants, thereby reducing the number of parasitic seeds in the soil. (Rac)-GR24 can be used in agricultural research.
Biochemical Assay Reagents  
1
HY-P0267 Melanotan (MT)-II
Melanotan (MT)-II is a melanocortin receptor agonist. Melanotan (MT)-II activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.
Melanocortin Receptor  
Anxiety or Fear-Related Disease   Obesity   Erectile Dysfunction  
1
HY-N2466 Melanotan I
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction.
Melanocortin Receptor   Drug Derivative  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Urogenital Disease   Leukemia/Lymphoma/Myeloma  
1
HY-W012734 L-Pipecolic acid
L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-N0583R Hydrocortisone (Standard)
Hydrocortisone (Standard) is the analytical standard of Hydrocortisone. This product is intended for research and analytical applications. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Breast Cancer  
1
HY-P71060 PTH Protein, Human (HEK293, His)
PTH Protein, or parathyroid hormone, raises calcium levels by dissolving bone salts and inhibiting kidney excretion. It also stimulates [1-14C]-2-deoxy-D-glucose transport and glycogen synthesis in osteoblastic cells, interacting with the PTH1R receptor and binding to its N-terminal extracellular domain for these effects. PTH Protein, Human (HEK293, His) is the recombinant human-derived PTH protein, expressed by HEK293 , with N-8*His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Peptide Hormone & Neuropeptides

1
HY-P70310 EGR1/ZNF225 Protein, Human (His)
The EGR1/ZNF225 protein is a multifunctional transcriptional regulator that binds to the EGR site in the promoter of target genes and is independent of cytosine methylation. It controls the transcription of multiple target genes, affecting responses to growth factors, DNA damage, and ischemia. EGR1/ZNF225 Protein, Human (His) is the recombinant human-derived EGR1/ZNF225 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

1
HY-P703226 HSP90B1 Protein, Human (His, Strep)
HSP90B1 Protein, Human (His, Strep) is the recombinant human-derived HSP90B1, expressed by E. coli , with Strep, His labeled tag. ,

Species: Human; Source: E. coli

1
HY-P83673 Cortisol Antibody
Cortisol Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cortisol.

Host: Mouse; Reactivity: Species independent

Polyclonal Antibodies Primary Antibodies

1
HY-K0513 RT Master Mix for qPCR III

MCE MCE Reverse Transcription Kit III is suitable for the conventional synthesis of cDNA from RNA and the stem-loop method for the synthesis of cDNA from microRNA (miRNA).

Molecular Biology RT-PCR Reverse transcription PCR

1
HY-B1203S Fludrocortisone-d5
Fludrocortisone-d5 (9α-Fludrocortisone-d5) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
Isotope-Labeled Compounds   Mineralocorticoid Receptor   Glucocorticoid Receptor   Apoptosis  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P2515 Transcriptional Intermediary Factor 2 (TIF2) (740-753)
Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a TIF-2 coactivator peptide composed of 14 amino acids and covers the residue range 740-753 of TIF-2 protein.
Histone Acetyltransferase  
/
HY-113053F Prostaglandin A1-biotin
Prostaglandin A1-biotin (PGA1-biotin) is a biotin-labeled Prostaglandin A1 (HY-113053). Prostaglandin A1-biotin can be found in the culture filtrate of rhizobia, and the culture filtrate containing this compound exhibits significant antiviral activity.
Drug Derivative  
Viral Infection  
/
HY-160261S EP300/CBP-IN-2
EP300/CBP-IN-2 is a potent EP300/CBP inhibitor that has good activity in vivo. EP300/CBP-IN-2 can be used for the research of cancer.
Histone Acetyltransferase   Epigenetic Reader Domain  
Cancer  
/
HY-P2139 Ranakinin
Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion.
Neurokinin Receptor   Phospholipase  
/
HY-P991673 Asedebart
Asedebart is a CHO-expressed human antibody that targets Adrenocorticotropic hormone (ACTH). Asedebart blocks the binding of ACTH to its receptor through antagonism. Asedebart has huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Asedebart can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Asedebart can be used for inflammatory diseases such as psoriasis and ulcerative colitis research.

Species: Human

Androgen Receptor  
Inflammation or Immune System Disease  
/
HY-113422S2 Tetrahydrocorticosterone-d3-1
Tetrahydrocorticosterone-d3-1 is the d3-1-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-P1390A d[Cha4]-AVP TFA
d[Cha4]-AVP TFA is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP TFA shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.
Vasopressin Receptor  
Metabolic or Endocrine Disease  
/
HY-P5007 Copeptin (human)
Copeptin (human) is a peptide biochemical reagent corresponding to the 39 amino acid sequence at the C-terminus of human pre-provasopressin, which serves as a stable surrogate biomarker reflecting the secretion of arginine vasopressin (AVP). Copeptin (human) can be used in studies related to AVP secretion, fluid and osmotic homeostasis, stress responses, and cardiovascular biomarkers.
Cardiovascular Disease  
/
HY-P11105 Short neuropeptide F
Short neuropeptide F is an insect neurohormone involved in regulating insect locomotor activity and circadian rhythm.
Others  
Neurological, Eye or Ear Disease  
/
HY-P3979 Defensin HNP 4
Defensin HNP 4 (HNP 4) is a host-defense peptide that has antimicrobial activity against Gram-negative bacteria. Defensin HNP 4 inhibits ACTH stimulated synthesis of Corticosterone (HY-B1618) in rat adrenal cell suspensions.
Bacterial   Melanocortin Receptor  
Infection  
/
HY-17571BS Oxytocin-d10 TFA
Oxytocin-d10 TFA (α-Hypophamine-d10 TFA) is the deuterium labeled Oxytocin TFA (HY-17571B). Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
Isotope-Labeled Compounds   Endogenous Metabolite   Oxytocin Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-D3003 M-H2S
M-H2S is an endoplasmic reticulum-targeted ratio-type near-infrared fluorescent probe (Ex/Em : 480 nm/560 nm) specifically designed for the detection of hydrogen sulfide (H2S) in living cells and zebrafish. M-H2S exhibits detection limit for H2S of 39.1 nM, and the fluorescence intensity ratio (F₆₅₀/F₅₆₀) within the range of 0-40 μM shows a linear relationship with the H2S concentration. M-H2S responds best under pH = 7.2 (the normal physiological pH of the endoplasmic reticulum) conditions, making it suitable for the detection of the microenvironment of the endoplasmic reticulum. M-H2S can be used to study the role of H2S in endoplasmic reticulum function, stress response, and related diseases.
Fluorescent Dye  
/
HY-124033 Aspinonene
Aspinonene is a bioactive compound that has the function of regulating plant growth and defense mechanisms. It can participate in biochemical signaling pathways in plants and affect various physiological responses such as growth, defense and adaptation to environmental stress.
Biochemical Assay Reagents  
/
HY-50698G BI 2536 (GMP)
BI 2536 (GMP) is BI 2536 (HY-50698) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-β) gene transcription.
Polo-like Kinase (PLK)   Epigenetic Reader Domain   Apoptosis  
/
HY-113422S1 Tetrahydrocorticosterone-d3
Tetrahydrocorticosterone-d3 is the d3-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-17461AR Cortisone acetate (Standard)
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P3539 Exendin-4 (3-39)
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.
GCGR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P992450 REGN6569
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001.

Species: Human

TNF Receptor  
Cancer  
/
HY-14930S Mirodenafil-d7
Mirodenafil-d7 (SK3530-d7) is the deuterium labeled Mirodenafil (HY-14930). Mirodenafil (SK3530) is an orally active, potent, reversible, and selective?phosphodiesterase?5 (PDE5)?inhibitor. Mirodenafil is a?glucocorticoid receptor?(GR)?modulator Mirodenafil activates the?Wnt/β-catenin?signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).
Isotope-Labeled Compounds   Apoptosis   Wnt   Phosphodiesterase (PDE)   Glucocorticoid Receptor   β-catenin  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P12115 Acorbine
Acorbine is an orally active, hepatoprotective tripeptide present in the brackish-water bivalve Corbicula japonica. Hydrolysis of Acorbine yields free β-alanine and ornithine, which mediate the host defense system of Corbicula japonica in response to biological stress and changes in growth conditions. Acorbine inhibits ethanol-induced hepatocyte death and liver injury. Acorbine can be used in studies related to liver diseases.
Drug Intermediate  
Liver Disease  
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HY-N6741S β-Zearalenol-13C18
β-Zearalenol-13C18 is the 13C-labeled β-Zearalenol. β-Zearalenol is a non-steroidal estrogenic mycotoxin synthesized by Fusarium species. β-Zearalenol potentially influences transcription and effects gene expression on translational level.
Isotope-Labeled Compounds  
/
HY-W784575A dGTPαS sodium
dGTPαS sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-B0077S1 Bendamustine-d8 hydrochloride
Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties.
Isotope-Labeled Compounds   DNA Alkylator/Crosslinker   Apoptosis  
Cancer  
/
HY-W784574A dCTPαS sodium
dCTPαS sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-B1540S Beclomethasone-d5
Beclomethasone-d5 is the deuterium labeled Beclometasone. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
Glucocorticoid Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P4497 Prolylserine
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB).
ERK  
Cancer  
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HY-N12744 2-O-trans-p-Coumaroylalphitolic acid
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity.
Glucocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-P11196 Allatostatin C
Allatostatin C (AstC) is a neuropeptide that suppresses gonadotropin production. Allatostatin C generates oogenesis rhythm by regulating juvenile hormone and vitellogenesis indirectly via insulin signaling. Allatostatin C can be used for neurological research.
Others  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-W127725 Thymolphthalexon tetrasodium
Thymolphthalexon (tetrasodium) is an organic compound commonly used as a reagent in biochemical assays. It belongs to the family of thioxanthone derivatives and has strong antioxidant properties. Thymolphthalexon has several applications in the study of free radical response, oxidative stress, and aging. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.
Biochemical Assay Reagents  
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HY-W583271 Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia.
Vasopressin Receptor   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-12956S2 Dinoprost-13C5
Dinoprost-13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.
Prostaglandin Receptor   Apoptosis   Autophagy   Endogenous Metabolite   Isotope-Labeled Compounds  
Metabolic or Endocrine Disease  
/
HY-131946 Menotropin
Menotropin (Menotrophin) is a hormone that can be extracted from the urine of postmenopausal women and has both follicle stimulating hormone (FSH) and luteinizing hormone (LH) activity.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P990902A Atigotatug (FUT8-KO)
Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a Fucosyl ganglioside GM1 (fuc-GM1)-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer.

Species: Human

Others  
Cancer  
/
HY-12270S T-5224-d8
T-5224-d8 is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
Isotope-Labeled Compounds   MMP   AP-1  
/
HY-B1203S1 Fludrocortisone-d2
Fludrocortisone-d2 (9α-Fludrocortisone-d2) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
Isotope-Labeled Compounds   Mineralocorticoid Receptor   Glucocorticoid Receptor   Apoptosis  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P1238 Neuromedin U, rat
Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.
Neuromedin U Receptor (NMUR)  
Neurological, Eye or Ear Disease  
/
HY-B0271S1 Pyrazinamide-13C,15N
Pyrazinamide-13C,15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
Autophagy   Bacterial   Antibiotic   Isotope-Labeled Compounds  
Infection  
/
HY-NP0209 Hydrocortisone-OVA
Hydrocortisone-OVA is a conjugate of Hydrocortisone (HY-N0583) and OVA peptide. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Glucocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B1812S3 Veratrole-d6
Veratrole-d6 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-P1245A Neuropeptide SF (human) acetate
Neuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
CRFR  
/
HY-N6678S (Rac)-Zearalanone-d6
(Rac)-Zearalanone-d6 is the d6-labeled (Rac)-Zearalanone (HY-N6678A). (Rac)-Zearalanone is an ATP-competitive HSP90 inhibitor with an EC50 of 2.3 μM. (Rac)-Zearalanone interferes with the binding of ATP to HSP90, impairs the chaperone function of HSP90, and promotes the degradation of client proteins. (Rac)-Zearalanone reduces intracellular accumulation of Raf-1, induces cleavage of caspase-3, and promotes Her2 degradation in a dose-dependent manner by disrupting the Her2-HSP90 interaction. (Rac)-Zearalanone can be used in the research of small cell lung cancer and breast cancer.
Isotope-Labeled Compounds   HSP   Raf   Caspase   EGFR  
Breast Cancer   Non-Small Cell Lung Cancer  
/
HY-N1964B Gibberellic acid Sterile Solution (1 mg/ml)
Gibberellic acid Sterile Solution (1 mg/mL) (GA3 Sterile Solution (1 mg/mL)) is a natural plant growth regulator with oral bioactivity. Gibberellic acid Sterile Solution (1 mg/mL) governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid Sterile Solution (1 mg/mL) optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid Sterile Solution (1 mg/mL) mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid Sterile Solution (1 mg/mL) can be used in studies of plant growth, metabolism, and abiotic stress responses.
Plant Growth Regulators   Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-150516S BET-IN-12
BET-IN-12 is an orally avtive inhibitor of bromodomain and extra-terminal (BET) with an IC50 of 0.9 nM for BRD4.
Epigenetic Reader Domain  
Cancer  
/
HY-P991855 RKER-216
RKER-216 is a human monoclonal IgG antibody inhibitor targeting ALK2 with a KD of 58.7 pM. RKER-216 reduces hepcidin transcription in Hep3B.RKER-216 competes with BMP ligands for binding to the extracellular domain of ALK2, thereby inhibiting BMP-SMAD signal. RKER-216 mobilizes tissue iron effectively in inflammatory conditions. RKER-216 improves microcytic anemia in a dose-dependent manner by inhibiting SMAD signaling to reduce hepcidin and promote iron absorption and utilization in vivo. RKER-216 can be used for research on anemia of inflammation.

Species: Human

TGF-β Receptor  
Iron Deficiency Anemia  
/
HY-W778408 Tamoxifen-13C6
Tamoxifen-13C6 (ICI 47699-13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER transgenic mouse.
Isotope-Labeled Compounds   HSP   Autophagy   Apoptosis   Estrogen Receptor/ERR  
Metabolic or Endocrine Disease  
/
HY-W013179S 18-Hydroxycorticosterone-d4
18-Hydroxycorticosterone-d4 is the deuterium labeled 18-Hydroxycorticosterone. 18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone, which can lead to serious electrolyte imbalances.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P11829 ACTR-AD1 2L
ACTR-AD1 2L is a ACTR-AD1 peptide. ACTR-AD1 2L inhibits CBP/p300-NCOA3 complex formation, modulates gene transcription, inhibits CBP/p300 acetylase activity, reduces acetylation levels, and exhibits antiproliferative activity. ACTR-AD1 2L binds with stronger affinity to its target proteins than the wild-type peptide. ACTR-AD1 2L can be used for the research of breast cancer.
Histone Acetyltransferase  
Breast Cancer  
/
HY-P10509 IE1 peptide
IE1 peptide refers to an antigenic peptide encoded by the immediate early (IE) gene of mouse cytomegalovirus (mCMV). IE1 peptide is one of the key antigenic peptides expressed during mCMV infection, plays a role in transcriptional activation in the life cycle of mCMV, and is one of the earliest genes expressed in the viral replication cycle. IE1 peptide is an important target for CD8+ T cell response and can be used to study the host immune response to mCMV infection.
CMV  
/
HY-D3485 Dexamethasone fluorescein
Dexamethasone fluorescein is a fluorescently labeled steroid conjugate that binds to glucocorticoid receptors. Dexamethasone fluorescein binds to glucocorticoid receptors. Dexamethasone fluorescein serves as a marker for evaluating the delivery of drugs via subconjunctival injection and intratympanic administration. Sustained transscleral diffusion is achieved when Dexamethasone fluorescein is delivered via fibrin sealant. Dexamethasone fluorescein can be used to investigate the binding and localization of glucocorticoid receptors.
Fluorescent Dye   Glucocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-B1402G Hydrocortisone hemisuccinate (GMP)
Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) is a GMP-grade version of Hydrocortisone hemisuccinate (HY-B1402). GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers. .
Interleukin Related  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W012389 5-Bromo-1,2-difluoro-3-methoxybenzene
5-Bromo-1,2-difluoro-3-methoxybenzene (5-Bromo-2,3-difluoroanisole) is a drug synthesis intermediate that can be used to synthesize a ligand of glucocorticoid receptor (GR).
Drug Intermediate  
/
HY-P10290 Neuropeptide Y (human) free acid
Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling.
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease  
/
HY-N15154 Tasiamide B
Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90.
Cathepsin   HSP  
/
HY-10966G SB-590885 (GMP)
SB-590885 GMP is SB-590885 (HY-10966) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer.
Raf   Apoptosis  
Colorectal Cancer   Blood Disease  
/
HY-125037 Diptoindonesin G
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer.
Estrogen Receptor/ERR   HSP  
/
HY-B1812R Veratrole (Standard)
Veratrole (Standard) is the analytical standard of Veratrole. This product is intended for research and analytical applications. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Reference Standards   Cytochrome P450  
/
HY-P992150 Altrakincept
Altrakincept is a recombinant hIL-4 receptor and IL-4 neutralizer. Altrakincept neutralizes endogenous IL-4, and prevents the decline of pulmonary function and acute asthma exacerbations after abrupt withdrawal of inhaled glucocorticoids.

Species: Human

Interleukin Related  
Pulmonary Disease   Asthma  
/
HY-NP186 Helix pomatia Agglutinin
Helix pomatia Agglutinin is a N-acetylgalactosamine (GalNAc) binding lectin, found in the reproductive gland of a Roman snail. Helix pomatia Agglutinin binds with high affinity (kD = 1.9-2.4 μM) steroid hormones: testosterone and progesterone. Helix pomatia Agglutinin interacts with adenine (kD = 5.4 μM) and arylaminonaphthalene sulfonate TNS (kD = 12 μM). Helix pomatia Agglutinin is commonly used for characterizing, imaging, or targeting glycoconjugates, and is also a very useful tool for glycomics analysis . Helix pomatia Agglutinin can be used for cancer prognosis study.
Biochemical Assay Reagents  
/
HY-P1544 Cerebellin
Cerebellin is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin can be used in neurological research.
Endogenous Metabolite   Adenylate Cyclase   PKA   Calcium Channel  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P11185 Hsp90β decapeptide
Hsp90β decapeptide is a C-terminal peptide of Hsp90β, which contains conserved TPR-domain MEEVD. Hsp90β decapeptide is able to bind tightly the Tah1 protein with a Kd of 1.0 μM.
HSP  
Cancer  
/
HY-158707 dTTPαS sodium
dTTPαS sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P5950 ACTH (6-24) (human)
ACTH (6-24) (human) (Adrenocorticotropic hormone (6-24)) is an ACTH fragment. ACTH (6-24) (human) is a competitive inhibitor of steroidogenesis induced by ACTH (1-39) and ACTH (5-24) (Kd:13.4 and 3.4 nM). ACTH (6-24) (human) inhibits corticosterone production and cAMP accumulation induced by hPTH 1-34.
Mineralocorticoid Receptor  
Blood or Cardio-cerebrovascular Disease  
/
HY-N1964A Gibberellic acid, suitable for plant cell culture
Gibberellic acid, suitable for plant cell culture (GA3, suitable for plant cell culture) is a natural plant growth regulator with oral bioactivity. Gibberellic acid, suitable for plant cell culture governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid, suitable for plant cell culture optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid, suitable for plant cell culture mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid, suitable for plant cell culture can be used in studies of plant growth, metabolism, and abiotic stress responses.
Plant Growth Regulators   Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-P0059S Teriparatide-d10
Teriparatide-d10 (Human parathyroid hormone-(1-34)-d10) is the deuterium labeled Teriparatide (HY-P0059). Teriparatide (Human parathyroid hormone-(1-34)) is a PTH1 receptor agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research.
Isotope-Labeled Compounds   Thyroid Hormone Receptor   PTHR  
/
HY-10211S Tanespimycin-d5
Tanespimycin-d5 (17-AAG-d5; NSC 330507-d5; CP 127374-d5) is the deuterium labeled Tanespimycin (HY-10211). Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.
Isotope-Labeled Compounds   Autophagy   Antibiotic   Bacterial   Mitophagy   Apoptosis   HSP  
Cancer  
/
HY-167847 IRI-514
IRI-514 is a synthetic peptide analogue of Thymopentin (HY-N7122). IRI-514 plays a role in modulating behavioral and neuroendocrine responses to stress.
Drug Derivative  
Neurological, Eye or Ear Disease  
/
HY-B0389S12 D-Glucose-5-13C
D-Glucose-5-13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-182709 Arabidopsis thaliana Callus Induction Medium
Arabidopsis thaliana Callus Induction Medium is a callus induction medium for Arabidopsis thaliana containing sucrose and hormones, but not agar.
Biochemical Assay Reagents  
/
HY-W127334 N-Palmitoyl phosphatidylethanolamine
N-Palmitoyl phosphatidylethanolamine (Tripelargonin) is endogenous lipid anorectic hormone, significantly reduces food intake in a dose-dependent manner
Biochemical Assay Reagents  
/
HY-W653939 11-Deoxy Corticosterone-d7
11-Deoxy Corticosterone-d7 is the deuterium labeled 11-Deoxy Corticosterone.
Isotope-Labeled Compounds  
/
HY-14823G Sobetirome (GMP)
Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.
Thyroid Hormone Receptor  
Metabolic or Endocrine Disease  
/
HY-P990873 Anti-BRCA1 Antibody (BR64)
Anti-BRCA1 Antibody (BR64) is a kind of mouse IgG1 κ chimeric antibody, targeting to human BRCA1. Anti-BRCA1 Antibody (BR64) reacts with BRCA1 (Breast cancer susceptibility gene 1) involved in tumor suppression, transcription, genomic stability, DNA repair and recombination. Anti-BRCA1 Antibody (BR64) can be used for the detections of immunofluorescence, western blot, and immunoprecipitation in cancer, such as breast and ovarian cancer.

Species: Human

DNA/RNA Synthesis  
Cancer  
/
HY-P11920 KEGIHAQ
KEGIHAQ is a novel signal peptide and an effector of the dipeptide transporter DppA. KEGIHAQ binds to the oligopeptide transporter OppA and inhibits OppA expression, which leads to compensatory up-regulation of DppA and thereby promotes dipeptide uptake. KEGIHAQ enhances the acid tolerance of bacteria by regulating the expression of transcriptional regulators rmal and spxA, thus promoting bacterial growth. KEGIHAQ can up-regulate genes related to amino acid metabolism to facilitate amino acid synthesis, energy production and various bacterial physiological activities. KEGIHAQ can serve as a nitrogen source-targeting peptide in high-density culture of lactic acid bacteria.
Bacterial  
/
HY-P992409 MEDI-5304
MEDI-5304 is a hedgehog antibody inhibitor with human sonic hedgehog (SHH) KD of 5.13 pmol/L, and human Indian hedgehog (IHH) KD of 34.7 pmol/L. MEDI-5304 binds and neutralizes SHH and IHH, blocks downstream target gene transcription, inhibits osteoblast differentiation. MEDI-5304 can be used for the research of colon cancer.

Species: Human

Hedgehog  
KRAS/Ras Mutation Colorectal Cancer  
/
HY-17461S Cortisone-13C3
Cortisone-13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-13567S1 Bendamustine-d8
Bendamustine-d8 is the deuterium labeled Bendamustine. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties.
DNA Alkylator/Crosslinker   Apoptosis  
Cancer  
/
HY-17461S3 Cortisone-d2
Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-B1812S2 Veratrole-d10
Veratrole-d10 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-10984S Pomalidomide-d5
Pomalidomide-d5 is deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
Isotope-Labeled Compounds   Ligands for E3 Ligase   Molecular Glues   Apoptosis  
Cancer  
/
HY-W653985 Cortodoxone-d7
Cortodoxone-d7 (11-Deoxycortisol-d7) is a deuterium labeled Cortodoxone (HY-77839). Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P2061 Leualacin
Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis.
Calcium Channel  
Blood or Cardio-cerebrovascular Disease  
/
HY-158622 AcycloATP sodium
AcycloATP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P10287 Neuropeptide W-30 (human)
Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human) activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-158588 3′-Azido-ddCTP sodium
3′-Azido-ddCTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P4786 Acetyl-ACTH (7-24) (human, bovine, rat)
Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release.
Androgen Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-142100 Licoagrochalcone C
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on NF-κB transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production.
NF-κB  
Inflammation or Immune System Disease  
/
HY-P992254 Anti-LAG-3 Antibody (BAP050)
Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with Kd values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).

Species: Human

LAG-3  
Cancer  
/
HY-18341F Biotin-(L-Thyroxine)
Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4).
Thyroid Hormone Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-17461S4 Cortisone-d9
Cortisone-d9 (17-Hydroxy-11-dehydrocorticosterone-d9) is the deuterium labeled Cortisone (HY-17461). Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P10371 PKHB1
PKHB1 (txCD47) is a CD47 agonist and Thrombospondin-1 peptide mimetic. PKHB1 activates CD47 and triggers Caspase-independent, calcium-dependent cell death via mitochondrial alterations, ROS production, endoplasmic reticulum morphological changes, and dissipation of mitochondrial membrane potential. PKHB1 induces the exposure of Calreticulin, HSP70, and HSP90, thereby driving immunogenic cell death. PKHB1 promotes intratumoral CD8+ T cell infiltration and inhibits breast tumorigenesis. PKHB1 reduces HSV-1 levels and alleviates the severity of herpes simplex keratitis. PKHB1 can be used in research related to breast cancer, herpes simplex keratitis, and T-cell acute lymphoblastic leukemia.
Reactive Oxygen Species (ROS)   Thrombopoietin Receptor   Mitochondrial Metabolism   HSP   HSV   CD47  
Inflammation or Immune System Disease   Breast Cancer   Acute Lymphoblastic Leukemia   HSV Infection  
/
HY-158587 3′-Azido-ddGTP sodium
3′-Azido-ddGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-P10054 SGKtide
SGKtide is used as an SGK(Serum and glucocorticoid-inducible kinase) substrate.
Others  
/
HY-P99951 Ripafollitropin alfa (bovine)
Ripafollitropin alfa (bovine) is a recombinant follicle-stimulating hormone fusion protein with chorionic gonadotropin.
Estrogen Receptor/ERR  
Metabolic or Endocrine Disease  
/
HY-139099A Diguanosine 5′-triphosphate lithium
Diguanosine 5′-triphosphate (Gp3G) lithium is a dinucleoside triphosphates. Diguanosine 5′-triphosphate lithium also is a virus-specific oligonucleotide. Diguanosine 5′-triphosphate lithium is needed for the synthesis of RNA during the transcription process.
DNA/RNA Synthesis   Nucleoside Antimetabolite/Analog  
Cancer  
/
HY-N12011 11-Oxoisomogroside V
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81%.
PGC-1α  
/
HY-P4413 (Des-Glu5)-ACTH (1-24) (human, bovine, rat)
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production.
Androgen Receptor  
Metabolic or Endocrine Disease  
/
HY-13757AS2 Tamoxifen-d2
Tamoxifen-d2 (ICI 47699-d2) is the deuterium labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).
Isotope-Labeled Compounds   Autophagy   HSP   Estrogen Receptor/ERR   Apoptosis  
Cancer   Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P10543 SMRT peptide
SMRT peptide is one of the co-repressors of BCL6 BTB domain interaction. SMRT peptide binds to the BTB domain of BCL6 and enhances the transcriptional repression function of BCL6. SMRT peptide can be used to study protein-protein interactions.
BCL6  
Cancer  
/
HY-N8421 Tabernanthine
Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences.
Potassium Channel  
Cardiovascular Disease  
/
HY-B1834S1 Megestrol-d5
Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause glucocorticoid-like effects and an increased risk of mental disorders.
Isotope-Labeled Compounds   Progesterone Receptor   Glucocorticoid Receptor  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P4493 (Des-Ser3)-ACTH (1-24) (human, bovine, rat)
(Des-Ser3)-ACTH (1-24) (human, bovine, rat) is a peptide analog of the adrenocorticotropic hormone (ACTH). ACTH stimulates the production of cortisol.
Others  
/
HY-13689G Go 6983 (GMP)
Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury.
PKC   Histone Methyltransferase   DNA Methyltransferase   DNA/RNA Synthesis  
Ischemia-Reperfusion Injury  
/
HY-B0389S3 D-Glucose-d1-1
D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P992352 ES005
ES005 is an anti-tumor compound and LAG3 inhibitor. ES005 blocks the interactions of LAG3 with MHC-II, LSECtin and FGL1, thereby effectively reversing the LAG3-mediated inhibition of T cell activation and NFAT reporter gene expression. ES005 exhibits significant tumor growth inhibitory effects in syngeneic mouse breast tumor models using humanized LAG3 knock-in mice. ES005 can be used for breast tumor-related research.

Species: Human

/
HY-D1686 Biotin-16-UTP
Biotin-16-UTP is an active substrate for RNA polymerase. Biotin-16-UTP can replace UTP in the in vitro transcription reaction for RNA labeling.
DNA Stain  
/
HY-P10111 Histone H3K9me3 (1-15)
Histone H3K9me3 (1-15) (H3(1-15)K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin. Trimethylation of histone H3 at lysine 9 is associated with gene repression, prevents transcription factor binding.
Others  
Cancer   Inflammation or Immune System Disease  
/
HY-W751099 Corticosterone-13C3
Corticosterone-13C3 is a 13C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.
Isotope-Labeled Compounds  
/
HY-P990966 Redalsomatropin alfa
Redalsomatropin alfa (JR-142) is a recombinant long-acting growth hormone. Redalsomatropin alfa extends its half-life through fusion with modified serum albumin. Redalsomatropin alfa is well-tolerated and can maintain IGF-1 levels. Redalsomatropin alfa can be used in research related to growth hormone deficiency.

Species: Human

GHR   IGF-1R  
/
HY-B1422R 9-Aminoacridine (Standard)
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections.
Reference Standards   Bacterial   HIV  
Klebsiella Pneumoniae Infection  
/
HY-A0070AS3 Liothyronine-d3
Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Endogenous Metabolite   Thyroid Hormone Receptor   Isotope-Labeled Compounds  
Cancer   Metabolic or Endocrine Disease  
/
HY-P0009S1 Cetrorelix-d10
Cetrorelix-d10 (SB-75-d10) is the d10-labeled Cetrorelix (HY-P0009). Cetrorelix is a competitive gonadotropin-releasing hormone receptor (GnRHR) antagonist with a Kd of 0.19 nM. Cetrorelix inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby suppressing the secretion of downstream sex steroids. Cetrorelix prevents ovulation, induces reversible reproductive shutdown and azoospermia, reduces ovarian fibrosis, improves superovulation outcomes, and inhibits chemotherapy-induced mitochondria-dependent apoptosis. Cetrorelix is applicable for fertility assistance research.
Isotope-Labeled Compounds   GnRH Receptor   Apoptosis  
Female Reproductive System Disease  
/
HY-N12056 Cyclo(L-leucyl-L-valyl)
Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA..

Source: Achromobacter xylosoxidans

Fungal  
Infection  
/
HY-P991221 ALD1613
ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH). ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-induced cyclic AMP accumulation in a mouse adrenal cell line (Y1) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats. ALD1613 can be used in the study of diseases associated with elevated ACTH levels.

Species: Human

Melanocortin Receptor  
Metabolic or Endocrine Disease  
/
HY-141914S Cortisol-21-glucuronide-d4 sodium
Cortisol-21-glucuronide-d4 (sodium) is the deuterium labeled Cortisol-21-glucuronide.
Isotope-Labeled Compounds  
/
HY-B1812S4 Veratrole-d2-1
Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-N10623 5-epi-Arvestonate A
5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells.

Source: Seriphidium transiliense

Tyrosinase  
Cancer  
/
HY-N14780 Pochonin D
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D is a copper ion carrier that can induce cuproptosis in triple-negative breast cancer cells by targeting PRDX1. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer.

Source: Humicola sp. FO-2942

HSP   Interleukin Related   TNF Receptor   Enterovirus   Cuproptosis  
Cancer   Inflammation or Immune System Disease   Parasitic Infection  
/
HY-13681S Methylprednisolone acetate-d6
Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.
Glucocorticoid Receptor   Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-116364C AZT triphosphate sodium
AZT triphosphate sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing.
Biochemical Assay Reagents   DNA/RNA Synthesis  
/
HY-176351S Growth hormone 22, U-15N
Growth hormone 22, U-15N is the 15N-labeled Growth hormone 22.
Isotope-Labeled Compounds  
/
HY-D2360 O-Carboranylphenoxyacetanilide
O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC50: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity.
HIF/HIF Prolyl-Hydroxylase   HSP  
Cancer  
/
HY-D2428 OVA-PEG-Cy3
OVA-PEG-Cy3 is a Cy3 (HY-D0822)-labeled OVA-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues.
Fluorescent Dye  
Cancer   Infection   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P9S0124 Anti-CD33 Antibody (OR000283)
Anti-CD33 Antibody (OR000283) (ORM-6151 Antibody; BMS-986497 Antibody) is an antibody targeting CD33. It is generated by grafting the FAb (H&L) sequence of Gemtuzumab (HY-P99971) onto an IgG1 Fc carrying the N297A mutation, which inhibits Fc-γR binding. Anti-CD33 Antibody (OR000283) can be used to construct degrader-antibody conjugates (DACs), such as ORM-6151 (HY-171792).

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-101402AR Cyclo(his-pro) TFA (Standard)
Cyclo(his-pro) (TFA) (Standard) is the analytical standard of Cyclo(his-pro) (TFA). This product is intended for research and analytical applications. Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.
Reference Standards   NF-κB   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-113440R 5-Methoxytryptophol (Standard)
5-Methoxytryptophol (Standard) is the analytical standard of 5-Methoxytryptophol. This product is intended for research and analytical applications. 5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism.
Reference Standards   Melatonin Receptor   MMP   Endogenous Metabolite   ERK   Interleukin Related   TNF Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P990721 Inpegsomatropin
Inpegsomatropin is a pegylated long-acting recombinant human growth hormone.
GHR  
Metabolic or Endocrine Disease  
/
HY-157585S 21-Dehydro Budesonide-d8-1
21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies.
Isotope-Labeled Compounds   Glucocorticoid Receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-10984S2 Pomalidomide-d4
Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<
Isotope-Labeled Compounds   Apoptosis   Molecular Glues   Ligands for E3 Ligase  
Cancer  
/
HY-164893 ABBV-154
ABBV-154 is an anti-TNF antibody-drug conjugate (ADC). ABBV-154 is composed of the humanized antibody Adalimumab (HY-P9908) conjugated with a glucocorticoid receptor modulator (HY-137883). ABBV-154 can be used in studies of rheumatoid arthritis, Crohn's disease and polymyalgia rheumatica.
Antibody-Drug Conjugates (ADCs)   TNF Receptor   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-121982 Cyclo(L-Phe-L-Val)
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions.
Fungal  
Fungal Infection  
/
HY-A0070AS2 Liothyronine-13C6-1
Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-D1236 Fluorescent brightener 71
Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and USP14, as well as a CD40 ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes gpx-4 and sod-4, and reversibly increases the protein levels of UCHL5 and USP14 through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer.
Parasite   Deubiquitinase   PARP  
Breast Cancer   Parasitic Infection  
/
HY-13757AS1 Tamoxifen-d3
Tamoxifen-d3 is the deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse.
Isotope-Labeled Compounds   Estrogen Receptor/ERR   Apoptosis   Autophagy   HSP  
Cancer  
/
HY-N6901 Luteolin 7-sulfate
Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis.
Epigenetic Reader Domain  
Metabolic or Endocrine Disease  
/
HY-B1812S Veratrole-d4
Veratrole-d4 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-P3069 γ-Neuropeptide (rabbit)
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B1812S1 Veratrole-d2
Veratrole-d2 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-N3298 Meranzin
Meranzin is an orally active antidepressant and GHSR modulator. Meranzin significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
mTOR   GHSR  
Depression  
/
HY-P3582 sGnRH-A
sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.
GnRH Receptor  
Metabolic or Endocrine Disease  
/
HY-P1558A ACTH (11-24) acetate
ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-W751835 Baloxavir-d4
Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity.
Isotope-Labeled Compounds  
Cancer  
/
HY-W744549 20β-Dihydrocortisol
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity.
Glucocorticoid Receptor   Drug Metabolite  
Obesity  
/
HY-W415108 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate
10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples.
Fluorescent Dye  
/
HY-N2273 Gymnestrogenin
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression.
LXR  
Metabolic or Endocrine Disease  
/
HY-113457S 11-Oxo etiocholanolone-d5
11-Oxo etiocholanolone-d5 (11-Ketoetiocholanolone-d5) is the deuterium labeled 11-Oxo etiocholanolone (HY-113457). 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a steroid. 11-Oxo etiocholanolone is a key indicator for detecting cortisol metabolites in feces and urine. 11-Oxo etiocholanolone has the potential to be a pheromone.
Isotope-Labeled Compounds   Endogenous Metabolite   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P0090S Calcitonin-13C6,15N4 (salmon) TFA
Calcitonin-13C6,15N4 (salmon) (Salmon calcitonin-13C6,15N4) TFA is 13C and 15N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
CGRP Receptor  
Metabolic or Endocrine Disease  
/
HY-B0389S14 D-Glucose-13C2
D-Glucose-13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N7240S (Rac)-Juvenile Hormone III-d3
Juvenile Hormone III-d3 is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays.
Isotope-Labeled Compounds   Others  
/
HY-13757S Tamoxifen-d3 hydrochloride
Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.
Apoptosis   HSP   Autophagy   Estrogen Receptor/ERR   Isotope-Labeled Compounds  
Cancer  
/
HY-N5130 Effusol
Effusol, a phenolic constituent from Juncus effuses, exhibits potent scavenging activity for DPPH and ABTS radicals, with IC50 values of 79 μM and 2.73 μM, respectively. Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampal function against stress-induced cognitive decline.
Free Radical Scavengers  
Neurological, Eye or Ear Disease  
/
HY-14648S5 Dexamethasone-d3-1
Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Mitophagy   Exosomes   Autophagy   ADC Payloads   Bacterial   Antibiotic   SARS-CoV   Complement System  
Cancer  
/
HY-N0583S3 Hydrocortisone-d3
Hydrocortisone-d3 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N7439 Mogroside VI B
Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription.
PGC-1α  
Metabolic or Endocrine Disease  
/
HY-164147 Somapacitan
Somapacitan is a growth hormone analog. Somapacitan is used for research on growth hormone deficiency.

Species: Human

Drug Derivative  
Metabolic or Endocrine Disease  
/
HY-10984S1 Pomalidomide-d3
Pomalidomide-d3 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
Ligands for E3 Ligase   Molecular Glues   Apoptosis  
Cancer  
/
HY-77839S1 Cortodoxone-d2
Cortodoxone-d2 is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B0389S8 D-Glucose-d1-4
D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N9921 Antcin A
Antcin A is an orally active modulator of p53 and glucocorticoid receptor (GR), with an IC50 of 8.55 μM against human GR. Through transcriptional activation of p53, Antcin A induces miR-200c and inhibits ZEB1, regulates epithelial-mesenchymal transition markers, and suppresses cancer cell migration/invasion. Antcin A activates GR, inhibits Na+/K+-ATPase and NLRP3 inflammasome assembly, pyroptosis (pyroptosis) and pro-inflammatory cytokine release, reduces hepatic lipid deposition, improves liver function, and reverses metabolic changes induced by the SARS-CoV-2 spike protein. Antcin A can be used in research related to breast cancer, head and neck cancer, non-alcoholic fatty liver disease, and coronavirus disease 2019 (COVID-19).

Source: Antrodia cinnamomea

Pyroptosis   NOD-like Receptor (NLR)   MDM-2/p53   Glucocorticoid Receptor   MicroRNA   Na+/K+ ATPase   SARS-CoV  
Digestive System Disease   Breast Cancer   Coronavirus Infection   Digestive System Inflammation  
/
HY-P10289A Neuropeptide W-30 (rat) acetate
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-P1858 Urocortin III, mouse
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
CRFR  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-B0389S7 D-Glucose-d1-3
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P991358 XOMA-213
XOMA-213 (LFA-102; X213) is a human monoclonal antibody (mAb) targeting the prolactin receptor (PRLR), with a Kd value of 2 nM against the human target. XOMA-213 blocks PRL-induced cell proliferation and inhibits the activation of multiple PRLR ligands, including PRL and human growth hormone (hGH). XOMA-213 suppresses PRL-induced phosphorylation of Stat5, Akt and ERK1/2 in cells. XOMA-213 induces tumor regression, delays disease progression, and inhibits PRLR signaling as well as tumor growth. XOMA-213 can be used in research related to breast cancer.

Species: Human

Estrogen Receptor/ERR   STAT   Akt  
Breast Cancer  
/
HY-118860 Corifollitropin alfa
Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.
Estrogen Receptor/ERR  
Metabolic or Endocrine Disease  
/
HY-N0583S5 Hydrocortisone-d2
Hydrocortisone-d2 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-101013 D-SNAP
D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.
Fluorescent Dye  
/
HY-P1245 Neuropeptide SF (human)
Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
CRFR  
/
HY-D2864 Aza-CyBz
Aza-CyBz is a NaCl-responsive near-infrared heptamethine cyanine fluorescent probe. Aza-CyBz has an excitation wavelength of 740 nm and detects signals in the range of 760-900 nm. NaCl induces Aza-CyBz to form ordered aggregates, resulting in fluorescence quenching. Aza-CyBz shows no obvious response to interfering substances such as plant carbohydrates, hormones, PEG and ROS. Aza-CyBz can enter plant mitochondria and reflect changes in their salt concentration, and can be used for visual imaging of salt stress in Arabidopsis thaliana root tips and living plants.
Fluorescent Dye  
/
HY-P990233 Anti-Mouse IFNγR/CD119 Antibody (GR-20)
Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IFNγR/CD119.Anti-Mouse IFNγR/CD119 Antibody (GR-20) reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. Anti-Mouse IFNγR/CD119 Antibody (GR-20) blocks the binding of IFNγ to CD119 therefore inhibiting IFNγ signaling. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma and C. trachomatis infected genital tract inflammation.

Species: Mouse

IFNAR  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-N2509 Iristectorigenin B
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β.
LXR  
Cardiovascular Disease  
/
HY-N0583S1 Hydrocortisone-d7
Hydrocortisone-d7 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W587724S 6β-Hydroxy Cortisol-d4
6β-Hydroxy Cortisol-d4 is a deuterium labeled compound.
Isotope-Labeled Compounds  
/
HY-P3862 [MePhe7]-Neurokinin B
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P1582A ACTH (1-14) TFA
ACTH (1-14) (TFA) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.
Adrenergic Receptor  
/
HY-P11341 Kisspeptin antagonist p271
Kisspeptin antagonist p271 is a Kisspeptin antagonist with cell-penetrating ability. Kisspeptin antagonist p271 can block the binding of endogenous Kisspeptin to GPR54 on pituitary somatotropes, thereby relieving the inhibition of growth hormone secretion. Kisspeptin antagonist p271 can specifically and significantly stimulate growth hormone secretion, while inhibiting luteinizing hormone without affecting prolactin or cortisol. Kisspeptin antagonist p271 can be used in the research of diseases related to insufficient growth hormone secretion.
Kisspeptin Receptor  
Metabolic or Endocrine Disease  
/
HY-77839R Cortodoxone (Standard)
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B1618S1 Corticosterone-d4
Corticosterone-d4 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-N7666 Prosaikogenin F
Prosaikogenin F is a monoglycoside with anticancer and hemolytic properties.
Others  
Cancer   Metabolic or Endocrine Disease  
/
HY-119906 Conglobatin
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo.

Source: Streptomyces conglobatus

HSP   Apoptosis  
/
HY-107577 Gedunin
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research.
HSP  
Inflammation or Immune System Disease  
/
HY-76632 4-Hydroxyisophthalic acid
4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE, enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies.
Cholinesterase (ChE)   SOD  
Neurodegenerative Disease  
/
HY-16985S Darolutamide-d4
Darolutamide-d4 (ODM-201-d4) is deuterium labeled Darolutamide (HY-16985). Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist, with a Ki of 11 nM for rat wild-type AR (wtAR) and an IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation. Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation. Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants. Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer.
Isotope-Labeled Compounds   Androgen Receptor  
Prostate Cancer  
/
HY-P1558 ACTH (11-24)
ACTH (11-24) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-P99925 Enoticumab
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively.

Species: Human

Notch  
Cancer   Metabolic or Endocrine Disease  
/
HY-13757AS Tamoxifen-​d5
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity.
Isotope-Labeled Compounds   Estrogen Receptor/ERR   HSP   Autophagy   Apoptosis  
Cancer  
/
HY-P5244 Tripeptide-32
Tripeptide-32 is a bioactive peptide that targets the PER1 gene. Tripeptide-32 can regulate circadian rhythms and stimulate the synthesis of cellular repair proteins, with anti-aging activity.
Others  
Metabolic or Endocrine Disease  
/
HY-B0389S5 D-Glucose-d2
D-Glucose-d2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W012734R L-Pipecolic acid (Standard)
L-Pipecolic acid (Standard) is an analytical standard of L-Pipecolic acid. This product is used for research and analytical applications. L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases.
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-101402A Cyclo(his-pro) TFA
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.
NF-κB   Endogenous Metabolite  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
/
HY-113151 18-Oxocortisol
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.
Mineralocorticoid Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-18570B 1-Naphthaleneacetic acid,suitable for plant cell culture
1-Naphthaleneacetic acid,suitable for plant cell culture (NAA) is a plant growth hormone. 1-Naphthaleneacetic acid,suitable for plant cell culture promotes plant growth and induces root cluster formation. Naphthaleneacetic acid,suitable for plant cell culture is applicable for plant cell culture.
Biochemical Assay Reagents  
/
HY-D1686B Biotin-16-UTP tetrasodium
Biotin-16-UTP tetrasodium is an active substrate for RNA polymerase. Biotin-16-UTP tetrasodium can replace UTP in the in vitro transcription reaction for RNA labeling.
DNA Stain  
/
HY-B1812 Veratrole
Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Cytochrome P450  
/
HY-P99932 Eftansomatropin alfa
Eftansomatropin alfa (GX-H9) is a fusion protein composed of rhGH (growth hormone) and immunoglobulin fragments. In Eftansomatropin alfa, rhGH is fused to a hybrid Fc domain comprising sequences of both IgD and IgG4. Eftansomatropin alfa can be used for the study of growth hormone deficiency (GHD).

Species: Human

Others  
Metabolic or Endocrine Disease  
/
HY-P0243 Luteinizing Hormone Releasing Hormone (LH-RH), salmon
Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.
GnRH Receptor  
Metabolic or Endocrine Disease  
/
HY-P0060A Tetracosactide acetate
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
CRFR   Melanocortin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P1390 d[Cha4]-AVP
d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.
Vasopressin Receptor  
Metabolic or Endocrine Disease  
/
HY-N7627 Regaloside C
Regaloside C is an anti-inflammatory agent and antioxidant that scavenges ABTS and DPPH free radicals. Regaloside C targets multiple molecules including TNF-α, MMP-2, ERα, AKT1, TLR4 and HSP90-α. Regaloside C is applicable to research related to inflammatory diseases.
Estrogen Receptor/ERR   Toll-like Receptor (TLR)   Akt   MMP   HSP  
Inflammation or Immune System Disease  
/
HY-P11428 DBCO-cyclo(RGDfK)
DBCO-cyclo (RGDfK) is a clickable DBCO-modified cyclic RGD peptide, and also a DBCO derivative of cyclo (RGDfK) (HY-P0023). DBCO-cyclo (RGDfK) is synthesized via an amide coupling reaction between DBCO-NHS ester and cyclo (RGDfK). DBCO-cyclo (RGDfK) can react with azide groups through copper-free click chemistry (SPAAC) to immobilize RGD peptides onto biomaterials or hydrogels. The RGD sequence in DBCO-cyclo (RGDfK) is recognizable by cellular integrins and promotes cell adhesion. DBCO-cyclo (RGDfK) can be used in studies related to tissue engineering, 3D cell culture, and surface functionalization of biomaterials.
Drug Derivative   Biochemical Assay Reagents  
/
HY-17461R Cortisone (Standard)
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W018324 5-Hydroxymethylcytosine
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes).
Endogenous Metabolite  
Metabolic or Endocrine Disease   Lung Cancer   Leukemia/Lymphoma/Myeloma   Alzheimer's Disease   Parkinson's Disease  
/
HY-P99867 Dusigitumab
Dusigitumab is a fully human IgG2λ monoclonal antibody that targets IGF-1 and IGF-2 with picomolar binding affinity. Dusigitumab blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R as well as activation of IR-A, thereby inhibiting the activation of downstream signaling pathways. Dusigitumab is applicable to research related to advanced solid tumors and hormone receptor-positive metastatic breast cancer.

Species: Human

Others  
Breast Cancer  
/
HY-113418 Beta-Cortol
Beta-Cortol is an O-glycosylated compound and cortisol metabolite. It can be isolated from the leaves of mulberry cultivar Yu 711, and its concentration decreases significantly when the plant is subjected to drought stress. Beta-Cortol serves as a biomarker, as serum Beta-Cortol levels in early non-small cell lung cancer models are downregulated to 1/8 of the preoperative level after tumor resection. Due to such dramatic changes under specific pathological conditions, Beta-Cortol is currently widely used in studies related to early non-small cell lung cancer.
Endogenous Metabolite  
Non-Small Cell Lung Cancer  
/
HY-113422 Tetrahydrocorticosterone
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-17461S1 Cortisone-d8
Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P99114 Sugemalimab
Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research.

Species: Human

PD-1/PD-L1  
Respiratory Disease   Non-Small Cell Lung Cancer  
/
HY-101402 Cyclo(his-pro)
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.
NF-κB   Endogenous Metabolite  
Pancreatic Cancer   Pain   Digestive System Inflammation  
/
HY-N3995 5β-Dihydrocortisol
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.
Apoptosis   Drug Metabolite  
Digestive System Disease   Breast Cancer   Digestive System Inflammation  
/
HY-P990294 Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis.

Species: Mouse

Transmembrane Glycoprotein   STAT   Collagen   Reactive Oxygen Species (ROS)   Interleukin Related  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-112803 GNE-371
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).
DNA/RNA Synthesis  
Cancer  
/
HY-P10533 Cysteine peptide
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses.
Tyrosinase  
/
HY-W145486 Calcium gluconate
Calcium gluconate is an orally effective calcium salt supplement. Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury.
Environmental Pollutants   Biochemical Assay Reagents  
Postoperative Pain   Acute Lung Injury   Osteoporosis  
/
HY-A0070R Liothyronine sodium (Standard)
Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Reference Standards   Thyroid Hormone Receptor   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-101417 Diethyl phosphate
Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats.
Endogenous Metabolite   Interleukin Related  
Digestive System Disease   Digestive System Inflammation  
/
HY-P1238A Neuromedin U, rat TFA
Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.
Neuromedin U Receptor (NMUR)  
Neurological, Eye or Ear Disease  
/
HY-W010162 H-Ala-Ala-OH
H-Ala-Ala-OH is a substrate of human intestinal oligopeptide transporter (PEPT1/SLC15A1), with an IC50 of 0.25 mM and an EC50 of 0.08 mM against human PEPT1. When used as a dipeptide linker in antibody-drug conjugates (ADCs) loaded with glucocorticoid receptor regulator payloads, H-Ala-Ala-OH enables efficient intracellular payload release.
Amino Acid Derivatives  
/
HY-P1858A Urocortin III, mouse TFA
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
CRFR  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P10238 MYBMIM
MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells.
Apoptosis  
Cancer  
/
HY-B0389S6 D-Glucose-d7
D-Glucose-d77 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-W009154 3,6-Dibromocarbazole
3,6-Dibromocarbazole is a glucocorticoid receptor (GR) inhibitor and Environmental pollutant. 3,6-Dibromocarbazole induces abnormal development of zebrafish embryos and disrupts the neurohormonal function of the hypothalamic-pituitary-adrenal axis in zebrafish larvae. 3,6-Dibromocarbazole increases the α-diversity of soil bacteria, alters community structure, enhances interspecific competition, regulates metabolic functions, and changes the abundance of genes related to nitrogen fixation, nitrification and carbon cycling. 3,6-Dibromocarbazole exerts endocrine-disrupting potential by interfering with the gluconeogenesis pathway.
Environmental Pollutants   Glucocorticoid Receptor   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-P0060 Tetracosactide
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
CRFR   Melanocortin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-N7240 (Rac)-Juvenile hormone III
(Rac)-Juvenile hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile hormone III possesses morphogenetic activity in insect assays.

Source: yellow mealworm

Others  
Metabolic or Endocrine Disease  
/
HY-12071G LDN193189 (GMP)
LDN193189 GMP is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva.
Organoid   TGF-β Receptor  
Cancer  
/
HY-129630 Tetrahydrocortisol
Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer.
Drug Metabolite   Glucocorticoid Receptor  
Lung Cancer   Breast Cancer   Ocular Hypertension  
/
HY-P1298A Sauvagine TFA
Sauvagine TFA is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine TFA activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine TFA can be used for research on central nervous system and blood diseases.
CRFR  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
/
HY-B1618R Corticosterone (Standard)
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite   iGluR  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-A0070AR Liothyronine (Standard)
Liothyronine (Standard) is the analytical standard of Liothyronine. This product is intended for research and analytical applications. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor   Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease   Metastatic Breast Cancer  
/
HY-113114 Tetrahydrocortisone
Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status.
Endogenous Metabolite   Glucocorticoid Receptor  
Digestive System Disease   Digestive System Inflammation   Type 2 Diabetes  
/
HY-N1193 Sulfuretin
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM.
NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Glucose Metabolism   Parkinson's Disease   Obesity  
/
HY-111974 β-D-Glucopyranosyl abscisate
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable abscisic acid (ABA) conjugate that accumulates in the vacuole and presumably also in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate allows the rapid formation of free ABA in response to abiotic stress conditions such as dehydration and salt stress. β-D-Glucopyranosyl abscisate contributes to the maintenance of ABA homeostasis.
Proton Pump  
Metabolic or Endocrine Disease  
/
HY-P2847 Urocortin II, mouse
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.
CRFR  
Metabolic or Endocrine Disease  
/
HY-N0583S2 Hydrocortisone-d4
Hydrocortisone-d4 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P99316 Sirukumab
Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-W004049 3-Hydroxybenzoic acid
3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study.
Endogenous Metabolite   Hydroxycarboxylic Acid Receptor (HCAR)  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain  
/
HY-NP0204 MSA Protein
MSA Protein (Mouse Serum Albumin) is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD).
ELOVL   Apoptosis   NOD-like Receptor (NLR)   Caspase   Tau Protein  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-101952G Prostaglandin E2 (GMP)
Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions.
Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P1752 Urocortin II, human
Urocortin II, human is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human has an effect of promoting satiet and neuroprotective effect. Urocortin II, human also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease.
CRFR   Bacterial   Parasite   NF-κB   ERK  
Metabolic or Endocrine Disease  
/
HY-B1203 Fludrocortisone
Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
Mineralocorticoid Receptor   Glucocorticoid Receptor   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Small Cell Lung Cancer  
/
HY-P1211 Adrenocorticotropic Hormone (ACTH) (1-39), human
Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist.
Melanocortin Receptor  
Infection   Metabolic or Endocrine Disease  
/
HY-P5971 TCMCB07
TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia. TCMCB07 has potential transport capabilities.
Melanocortin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P1295 Urocortin, human
Urocortin, human, a 40-aa neuropeptide, acts as an agonist of endogenous CRF receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively.
CRFR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-132809 Baxdrostat
Baxdrostat is a aldosterone synthase inhibitor.
Mineralocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-109017 Vamorolone
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
Glucocorticoid Receptor   Mineralocorticoid Receptor   NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
/
HY-134816 D-Glucan
D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism).
C-type Lectin-like Receptors (CTLRs)   Toll-like Receptor (TLR)  
Cancer   Inflammation or Immune System Disease   Glucose Metabolism  
/
HY-P7183 GH/Somatotropin Protein, Human
GH Protein, Human is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the study of growth disorders.

Species: Human; Source: E. coli

Cytokines and Growth Factors Peptide Hormone & Neuropeptides Growth Hormone/Somatotropin

/
HY-P7360 GH/Somatotropin Protein, Human (CHO)
GH Protein, Human (CHO) is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the study of growth disorders.

Species: Human; Source: CHO

Cytokines and Growth Factors Peptide Hormone & Neuropeptides Growth Hormone/Somatotropin

/
HY-P704104 HSP90AA1 Protein, Human (sf9, His)
The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (sf9, His) is the recombinant human-derived HSP90AA1 protein, expressed by Sf9 insect cells, with N-His labeled tag.

Species: Human; Source: Sf9 insect cells

/
HY-P702562 PTHrP Protein, Human (His)
The PTHrP protein is a key neuroendocrine peptide that regulates multiple cellular processes, including growth, development, migration, differentiation, and survival. It plays an integral role in epithelial calcium transport and key developmental events such as endochondral bone development, mammary gland, and tooth formation. PTHrP Protein, Human (His) is the recombinant human-derived PTHrP protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

/
HY-P7112 PTH Protein, Human
PTH Protein, Human is a major regulator of mineral ion metabolism.

Species: Human; Source: E. coli

Cytokines and Growth Factors Peptide Hormone & Neuropeptides

/
HY-P76664 STAT4 Protein, Human (sf9, His)
The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P75931 Myocilin Protein, Human (HEK293, His)
Myofin is a secreted glycoprotein that regulates diverse cellular processes such as adhesion, cytoskeletal organization, and migration. It promotes matrix adhesion, spreading, and focal contact formation while negatively affecting cell-matrix adhesion and stress fiber assembly through Rho protein signaling. Myocilin Protein, Human (HEK293, His) is the recombinant human-derived Myocilin protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P70240 Somatoliberin/GHRH Protein, Human (HEK293, Fc)
The ghrelin/GHRH protein, also known as GRF (Growth Hormone Releasing Factor), is released by the hypothalamus and plays a key role in growth hormone regulation. It stimulates the pituitary gland to secrete growth hormone, which coordinates body growth and development. Somatoliberin/GHRH Protein, Human (HEK293, Fc) is the recombinant human-derived Somatoliberin/GHRH protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

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HY-P702781 NR3C1 Protein, Human (His)
NR3C1 Protein, Human (His) is the recombinant human-derived NR3C1, expressed by E. coli , with C-6*His labeled tag.

Species: Human; Source: E. coli

/
HY-P78448 AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag)
AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human AITRL (Q72-S199) trimer with N-terminal His and Flag tag, which is expressed in HEK293.

Species: Human; Source: HEK293

Cytokines and Growth Factors TNF Superfamily TNF Superfamily Ligands GITRL/AITRL

/
HY-P73686 PTH Protein, Human (GST)
PTH Protein, or parathyroid hormone, raises calcium levels by dissolving bone salts and inhibiting kidney excretion. It also stimulates [1-14C]-2-deoxy-D-glucose transport and glycogen synthesis in osteoblastic cells, interacting with the PTH1R receptor and binding to its N-terminal extracellular domain for these effects. PTH Protein, Human (GST) is the recombinant human-derived PTH protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

Cytokines and Growth Factors Peptide Hormone & Neuropeptides

/
HY-P700610 GH/Somatotropin Protein, Human (Biotinylated, HEK293, N-His, C-Avi)
Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (Biotinylated, HEK293, N-His, C-Avi) is the recombinant human-derived GH/Somatotropin protein, expressed by HEK293 , with C-Avi, N-10*His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Peptide Hormone & Neuropeptides Growth Hormone/Somatotropin

/
HY-P701993 Sox2 Protein, Human
Sox2 protein is a key transcription factor that forms a trimeric complex with OCT4 and controls the expression of genes critical for embryonic development (YES1, FGF4, UTF1, ZFP206). It binds the NANOG enhancer and is critical for early embryogenesis and stem cell pluripotency. Sox2 Protein, Human is the recombinant human-derived Sox2 protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

/
HY-P703571 HSP90b Protein, Human (sf9)
HSP90b Protein, Human (sf9) is the recombinant human-derived HSP90b, expressed by sf9 insect cells , with tag Free labeled tag.

Species: Human; Source: Sf9 insect cells

/
HY-P75164 GITR Protein, Mouse (HEK293, His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Mouse (HEK293, His) is a recombinant protein with a C-terminal His label and is produced in HEK293 cells.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

/
HY-P701783 SGK Protein, Human (Inactive, sf9)
SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK Protein, Human (sf9) is the recombinant human-derived SGK protein, expressed by sf9 insect cells , with tag free.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC SGK SGK1/SGK

/
HY-P73076 GITR Protein, Human (HEK293, His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, His) is a recombinant protein with a C-terminal His label, It consists of 161 amino acids (M1-E161) and is produced in HEK293 cells.

Species: Human; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

/
HY-P73085 GH/Somatotropin Protein, Human (His)
Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-10*His labeled tag.

Species: Human; Source: E. coli

Cytokines and Growth Factors Peptide Hormone & Neuropeptides Growth Hormone/Somatotropin

/
HY-P70683 GITR Protein, Human (HEK293, hFc)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, hFc) is a recombinant protein with a C-terminal Fc label, It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

Species: Human; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P78640 GITR Protein, Canine (HEK293, His)
GITR is a type I transmembrane protein. GITR mediates signal transduction through NF-kB and MAPK pathways. Protects T cells from cell death induced by TCR activation. GITR inhibits proliferation and induces apoptosis of Multiple Myeloma (MM) cells in vitro and in vivo. GITR Protein, Canine (HEK293, His) is the recombinant canine-derived GITR protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Canine; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P71357 TFIIB Protein, Human (GST)
TFIIB protein is a general transcription factor involved in the initiation of RNA polymerase II. TFIIB Protein, Human (GST) is the recombinant human-derived TFIIB protein, expressed by E. coli , with N-GST labeled tag.

Species: Human; Source: E. coli

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HY-P71587 Nmes1 Protein, Mouse (His-SUMO)
Nmes1 protein is prominently expressed in diverse tissues such as vertebrae, brain, intestine, and stomach. Nmes1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Nmes1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

Species: Mouse; Source: E. coli

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HY-P72051 HSP90AA1 Protein, Sus scrofa (sf9, His)
HSP90AA1 is a molecular chaperone that regulates target proteins involved in cell cycle control and signal transduction. It interacts with co-chaperones to regulate substrate recognition and chaperone function. HHSP90AA1 Protein, Sus scrofa (sf9, His) is the recombinant HSP90AA1 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

Species: Others; Source: Sf9 insect cells

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HY-P72631 GITR Protein, Mouse (HEK293, Fc-His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Mouse (HEK293, Fc-His) is a recombinant protein with a C-terminal Fc label and a C-terminal His label, It consists of 132 amino acids (S22-H153) and is produced in HEK293 cells.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P74176 ELK1 Protein, Human (sf9, His-GST)
The ELK1 protein is a transcription factor that binds to purine-rich DNA and forms a ternary complex with SRF on the serum response element. It induces transcription, especially upon stimulation of the JNK signaling pathway. ELK1 Protein, Human (sf9, His-GST) is the recombinant human-derived ELK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P75163 GITR Protein, Rat (HEK293, Fc)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Rat (HEK293, Fc) is a recombinant protein with a C-terminal Fc label, It consists of 121 amino acids (M1-K121) and is produced in HEK293 cells.

Species: Rat; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P75165 GITR Protein, Mouse (HEK293, Fc)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Mouse (HEK293, Fc) is a recombinant protein with a C-terminal Fc label and is produced in HEK293 cells.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P76063 SGK3 Protein, Human (Active, sf9, GST)
The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (sf9, GST) is the recombinant human-derived SGK3 protein, expressed by Sf9 insect cells , with GST tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC Cytokine-independent Survival Kinase (SGK3) SGK

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HY-P76362 GITR Protein, Cynomolgus (HEK293, His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Cynomolgus (HEK293, His) is a recombinant protein with a C-terminal His label, It consists of 155 amino acids (M1-E155) and is produced in HEK293 cells.

Species: Cynomolgus; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P77243 TMED4 Protein, Human (HEK293, Fc)
The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag.

Species: Human; Source: HEK293

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HY-P78716 GITR Protein, Cynomolgus (HEK293, Fc)
GITR Protein, Cynomolgus (HEK293, Fc) is the recombinant Rhesus Macaque-derived GITR protein, expressed by HEK293, with C-hFc labeled tag.

Species: Rhesus Macaque; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P73730 PARM-1 Protein, Human (HEK293, His)
PARM-1 Protein is a highly glycosylated, mucin-like type 1 transmembrane protein primarily located at the plasma membrane and in the endocytic pathway. PARM-1 is also a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response, and its presence in most human tissues with especially high expression in heart, kidney and placenta. PARM-1 may regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. PARM-1 Protein, Human (HEK293, His) is the recombinant human-derived PARM-1 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P75363 CDC37 Protein, Mouse (sf9)
The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells, with tag free.

Species: Mouse; Source: Sf9 insect cells

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HY-P77242 TMED4 Protein, Human (HEK293, His)
The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, His) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

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HY-P701784 SGK Protein, Human (sf9, His, GST)
SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK Protein, Human (sf9, His, GST) is the recombinant human-derived SGK protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC SGK SGK1/SGK

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HY-P701831 YSK/STK25 Protein, Human (Active, sf9, GST)
YSK Protein, an oxidant stress-activated serine/threonine kinase, plays a role in the cellular response to environmental stress. It regulates protein transport, cell adhesion, and polarity complexes at the Golgi apparatus, essential for orchestrating cell migration. YSK/STK25 Protein, Human (sf9, GST) is the recombinant human-derived YSK protein, expressed by sf9 insect cells , with N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins STE

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HY-P702904 PCAF Protein, Human (His)
PCAF Protein, Human (His) is the recombinant human-derived PCAF, expressed by E. coli , with N-6*His labeled tag. ,

Species: Human; Source: E. coli

Enzymes & Regulators Transferases (EC 2)

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HY-P703123 ETV6 Protein, Human (His, Strep)
ETV6 Protein, Human (His, Strep) is the recombinant human-derived ETV6, expressed by E. coli , with Strep, His labeled tag.

Species: Human; Source: E. coli

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HY-P703281 IRF9 Protein, Human (Sf9, His)
IRF9 Protein, Human (Sf9, His) is the recombinant human-derived IRF9 protein, expressed by E. coli, with His tag.

Species: Human; Source: E. coli

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HY-P703283 IRF9 Protein, Human (His, Strep)
IRF9 Protein, Human (His, Strep) is the recombinant human-derived IRF9, expressed by E. coli , with Strep, His labeled tag. ,

Species: Human; Source: E. coli

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HY-P703296 IRF9 Protein, Mouse
IRF9 Protein, Mouse is the recombinant mouse-derived IRF9 protein, expressed by E. coli, with tag free tag.

Species: Mouse; Source: E. coli

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HY-P703570 HSP90 Protein, Human (Biotinylated, Avi)
HSP90 Protein, Human (Biotinylated, Avi) is the recombinant human-derived HSP90, expressed by E. coli , with Avi labeled tag. ,

Species: Human; Source: E. coli

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HY-P703572 HSP90b Protein, Human (sf9, His, Strep)
HSP90b Protein, Human (sf9, His, Strep) is the recombinant human-derived HSP90b, expressed by sf9 insect cells , with Strep, His labeled tag.

Species: Human; Source: Sf9 insect cells

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HY-P705599 SGK2 Protein, Human (Active, sf9, GST)
The SGK2 protein is a serine/threonine protein kinase that complexly regulates multiple cellular processes, overseeing ion channels, membrane transporters, and critical aspects of cell growth, survival, and proliferation. Its effects include upregulation of key components such as Na(+) and K(+) channels, amino acid and glutamate transporters, receptors, Na(+)/H(+) exchangers, and Na(+)/K(+) ATPase. SGK2, Human (Active, sf9, GST) is the recombinant human-derived SGK2 protein, expressed by Sf9 insect cells, with labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC SGK SGK2

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HY-P706118 Runx3 Protein, Human (His, Myc)

Species: Human; Source: E. coli

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HY-P703083 HSP90AA1 Protein, Human (His, Avi)
The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His, Avi) is the recombinant human-derived HSP90AA1, expressed by E. coli, with C-Avi, C-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P706100 SGK Protein, Human (Active, S422D, sf9, His-GST)
SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK, Human (Active, S422D, sf9, His-GST) is the recombinant human-derived SGK protein, expressed by Sf9 insect cells, with N-6*His;N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) AGC SGK SGK1/SGK

/
HY-P706101 SGK2 Protein, Human (Active, S356D, sf9, His-GST)
The SGK2 protein is a serine/threonine protein kinase that complexly regulates multiple cellular processes, overseeing ion channels, membrane transporters, and critical aspects of cell growth, survival, and proliferation. Its effects include upregulation of key components such as Na(+) and K(+) channels, amino acid and glutamate transporters, receptors, Na(+)/H(+) exchangers, and Na(+)/K(+) ATPase. SGK2, Human (Active, S356D, sf9, His-GST) is the recombinant human-derived SGK2 protein, expressed by Sf9 insect cells, with N-6*His;N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) AGC SGK SGK2

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HY-P706229 HSP90AA1 Protein, Human (291a.a, His)
The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (291a.a, His) is the recombinant human-derived HSP90AA1, expressed by E. coli, with C-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P80714 Hsp90 alpha/beta Antibody (YA356)
Hsp90 alpha/beta Antibody (YA356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp90 alpha/beta.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80187 Hsp90 beta Antibody (YA355)
Hsp90 beta Antibody (YA355) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp90 beta.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82796 Cyclooxygenase 2 Antibody (YA2541)
Cyclooxygenase 2 Antibody (YA2541) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclooxygenase 2.

Host: Rabbit; Reactivity: Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80143 Glucocorticoid Receptor alpha Antibody (YA754)
Glucocorticoid Receptor alpha Antibody (YA754) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucocorticoid Receptor alpha.

Host: Mouse; Reactivity: Human, Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80464 Phospho-Hormone sensitive lipase (Ser853) Antibody (YA189)
Phospho-Hormone sensitive lipase (Ser853) Antibody (YA189) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Hormone sensitive lipase (Ser853).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P83433 PAX8 Antibody (YA3178)
PAX8 Antibody (YA3178) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAX8.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87175 Hsp90 alpha Antibody(YA6866)
Hsp90 alpha Antibody(YA6866) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp90 alpha.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P83995 Hsp90 alpha Antibody (YA3692)
Hsp90 alpha Antibody (YA3692) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp90 alpha.

Host: Mouse; Reactivity: Human, Mouse, Monkey

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82439 ATF5 Antibody (YA2184)
ATF5 Antibody (YA2184) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATF5.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83522 Growth Hormone 1 Antibody (YA3267)
Growth Hormone 1 Antibody (YA3267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Growth Hormone 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80687 Glucocorticoid Receptor Antibody (YA412)
Glucocorticoid Receptor Antibody (YA412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81780 SGK1 Antibody (YA1525)
SGK1 Antibody (YA1525) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SGK1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P84003 Hsp90 beta Antibody (YA3700)
Hsp90 beta Antibody (YA3700) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp90 beta.

Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P81499 Islet 1 Antibody (YA1244)
Islet 1 Antibody (YA1244) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Islet 1.

Host: Rabbit; Reactivity: Human, Mouse, Rat, Monkey, Pig

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82850 Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)
Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Glucocorticoid Receptor (Ser226).

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P85477 TRIM33 Antibody (YA5169)
TRIM33 Antibody (YA5169) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TRIM33.

Host: Mouse; Reactivity: Human, Mouse, Rat, Bovine, Dog, Pig

Monoclonal Antibodies Primary Antibodies

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HY-P86644 Hsp90 beta Antibody (YA6336)
Hsp90 beta Antibody (YA6336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp90 beta.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810358 ATF1 Antibody (YA9680)
ATF1 Antibody (YA9680) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ATF1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80687A Glucocorticoid Receptor Antibody (YA412)(PBS only)
Glucocorticoid Receptor Antibody (YA412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80714A Hsp90 alpha/beta Antibody (YA356)(PBS only)
Hsp90 alpha/beta Antibody (YA356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp90 alpha/beta.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810881 CD42c Antibody
CD42c Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CD42c.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811175 Phospho-GRLF1 (Tyr1105) Antibody
Phospho-GRLF1 (Tyr1105) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-GRLF1 (Tyr1105).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P81707 Parathyroid Hormone Receptor 1 Antibody (YA1452)
Parathyroid Hormone Receptor 1 Antibody (YA1452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82854 Phospho-Hormone Sensitive Lipase (Ser855) Antibody (YA2599)
Phospho-Hormone Sensitive Lipase (Ser855) Antibody (YA2599) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Hormone Sensitive Lipase (Ser855).

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P82906 ATF7 Antibody (YA2651)
ATF7 Antibody (YA2651) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATF7.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83522A Growth Hormone 1 Antibody (YA3267)(PBS only)
Growth Hormone 1 Antibody (YA3267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Growth Hormone 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P83672 Corticosterone Antibody
Corticosterone Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Corticosterone.

Host: Mouse; Reactivity: Species independent

Polyclonal Antibodies Primary Antibodies

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HY-P83995A Hsp90 alpha Antibody (YA3692)(PBS only)
Hsp90 alpha Antibody (YA3692) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp90 alpha.

Host: Mouse; Reactivity: Human, Mouse, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P84003A Hsp90 beta Antibody (YA3700)(PBS only)
Hsp90 beta Antibody (YA3700) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hsp90 beta.

Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey

Monoclonal Antibodies Primary Antibodies

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HY-P85339 Parathyroid Hormone Antibody (YA5031)
Parathyroid Hormone Antibody (YA5031) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Parathyroid Hormone.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85340 Parathyroid Hormone Receptor 1 Antibody (YA5032)
Parathyroid Hormone Receptor 1 Antibody (YA5032) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85596 Hsp90 beta Antibody (YA5288)
Hsp90 beta Antibody (YA5288) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp90 beta.

Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey, Hamster

Monoclonal Antibodies Primary Antibodies

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HY-P85607 BAG1 Antibody (YA5299)
BAG1 Antibody (YA5299) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BAG1.

Host: Mouse; Reactivity: Human, Mouse

Monoclonal Antibodies Primary Antibodies

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HY-P87081 SOX1 Antibody (YA6774)
SOX1 Antibody (YA6774) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOX1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P87521 PRDM16 Antibody (YA7205)
PRDM16 Antibody (YA7205) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to PRDM16.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P810551 Phospho-Hormone sensitive lipase (Ser660) Antibody (YA9820)
Phospho-Hormone sensitive lipase (Ser660) Antibody (YA9820) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Hormone sensitive lipase (Ser660).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P810879 GHRH Receptor Antibody
GHRH Receptor Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GHRH Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811029 ATF7 Antibody
ATF7 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ATF7.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811200 Zhangfei Antibody
Zhangfei Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Zhangfei.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P82850A Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)(PBS only)
Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Glucocorticoid Receptor (Ser226).

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P85192 Glucocorticoid Receptor Antibody (YA4884)
Glucocorticoid Receptor Antibody (YA4884) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86539 Glucocorticoid Receptor Antibody (YA6231)
Glucocorticoid Receptor Antibody (YA6231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-K0272 ConA Agarose

MCE ConA agarose is prepared by covalently coupling ConA to agarose and is widely used for the separation and purification of glycoproteins, membrane proteins, glycolipids, polysaccharides, membrane vesicles containing mannose or glucose residues, IgM, and lipoprotein hormones.

Protein Biology Protein Purification Agarose Beads

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HY-K2027 OptiLNP Gene Editing Kit

MCE OptiLNP Gene Editing Kit is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing in common cells (adherent or suspension cells).

Cell Biology Cell Culture Cell Transfection

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HY-K2028 OptiLNP Gene Editing Kit (Immune Cells)

MCE OptiLNP Gene Editing Kit (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing inimmune cells.

Cell Biology Cell Culture Cell Transfection

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HY-K2030 Lentivirus Packaging Kit

MCE Lentivirus Packaging Kit is based on the second-generation lentiviral packaging system and is also compatible with both second- and third-generation packaging plasmids. Lentiviruses produced using this kit exhibit high infection efficiency and a broad host range, enabling stable and sustained expression of exogenous genes in host cells.

Cell Biology Cell Culture Lentivirus

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HY-K3035 G-5 Supplement (100×)

MCE G-5 Supplement (100×) is a serum-free, chemically defined cell culture supplement developed based on the classic Bottenstein G-5 formulation. It is suitable for the culture of primary glial cells and neural cells with myelination properties. This supplement contains growth factors, hormones, insulin, transferrin, and other components related to cell growth and maintenance.

Cell Biology Cell Culture Cell Culture Supplements

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HY-KE7066 FnCas12a

FnCas12a(Cpf1), is an RNA-guided, DNA-editable recombinant endonuclease that can be used for gene editing and detection.

Molecular Biology Restriction Endonuclease

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HY-KE8010 Exonuclease I

This product is obtained by expressing the Exo I gene (E. coli) in Escherichia coli and then purifying and isolating it multiple times.

Molecular Biology Vector Construction Endonuclease

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Keywords

glucocorticoid oscillatory rhythms | ultradian rhythm | cortisol pulsatility | corticosterone | HPA axis | stress response | glucocorticoid receptor | circadian rhythm | hormone pulsatility | GR signaling | chromatin accessibility | pulsatile gene transcription | HSP90 | CBP/p300 | cortisol chronotherapy | adrenal insufficiency | neuroendocrinology | stress adaptation