Ar - androgen receptor Gene

Also Known as Tfm; Andr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24208

About Ar

Primary_assembly X: 63,104,771-63,273,925 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 277 orthologues, 8 paralogues and is associated with 62 phenotypes. Biased expression in Adrenal (RPKM 352.8), Uterus (RPKM 74.9) and 7 other tissues.

Summary

Enables several functions, including androgen binding activity; Androgen Receptor binding activity; and nuclear receptor activity. Involved in several processes, including cellular response to hormone stimulus; mating; and regulation of transcription, DNA-templated. Located in several cellular components, including axon; dendrite; and nucleus. Used to study hypertension; osteoporosis; prostate adenocarcinoma; prostate cancer; and prostatic hypertrophy. Biomarker of acute kidney failure and androgen insensitivity syndrome. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorder of sexual development (multiple); reproductive organ Cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (Androgen Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ar Products (1)

mRNA Protein Name
NM_012502.2 NP_036634.2 androgen receptor
Molecular Function GO Annotation Evidence References Source
enables androgen binding IMP
IMP: Inferred from mutant phenotype
2341409 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
3499428 RGD
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
9710597 RGD
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
2341409 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12350225 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17223690 RGD
enables ribonucleotide binding IDA
IDA: Inferred from direct assay
6193790 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10385402 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
11875111 RGD
Biological Process GO Annotation Evidence References Source
involved in androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
2341409 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
2502458 RGD
involved in cellular response to steroid hormone stimulus IEP
IEP: Inferred from expression pattern
2341409 RGD
involved in copulation IMP
IMP: Inferred from mutant phenotype
15178162 RGD
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
28776866 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
2598758 RGD
involved in locomotion IMP
IMP: Inferred from mutant phenotype
28776866 RGD
involved in male courtship behavior IMP
IMP: Inferred from mutant phenotype
15178162 RGD
involved in male sex differentiation IMP
IMP: Inferred from mutant phenotype
2341409 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10385402 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10385402 RGD
involved in positive regulation of hippocampal neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18289534 RGD
involved in positive regulation of locomotion IMP
IMP: Inferred from mutant phenotype
28776866 RGD
involved in positive regulation of penile erection IMP
IMP: Inferred from mutant phenotype
21315100 RGD
involved in prostate gland growth IEP
IEP: Inferred from expression pattern
3628973 RGD
involved in reproductive behavior IDA
IDA: Inferred from direct assay
20392832 RGD
involved in response to environmental enrichment IMP
IMP: Inferred from mutant phenotype
28776866 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10913783 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
3678734 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
15596216 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
16286851 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
27602328 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
2644508 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
10913783 RGD
involved in skeletal muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
7957162 RGD
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
15347734 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
12865346 RGD
located in cytosol IDA
IDA: Inferred from direct assay
3678734 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12865346 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
6466649 RGD
located in nucleus IDA
IDA: Inferred from direct assay
3678734 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ar Protein Structure

Androgen_recep

Androgen_recep: cl27454 (5 - 442)

NR_DBD_AR

NR_DBD_AR: cd07173 (536 - 617)

NR_LBD_AR

NR_LBD_AR: cd07073 (654 - 899)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 902 a.a.
Protein Preferred Names Protein Names

androgen receptor

  • androgen receptor (Testicular feminization), same as Tfm

  • dihydrotestosterone receptor

  • nuclear receptor subfamily 3 group C member 4

Orthologs Information

Species Symbol Source ID
Homo sapiens Ar NCBI NCBI:367