1. Gene
  2. Ar - androgen receptor Gene

Ar - androgen receptor Gene

Mus musculus

Also known as Tfm

Gene ID: 11835 | Gene type: protein coding

About Ar

Chromosome X: 97,192,375-97,366,821 forward strand.GRCm39:CM001013.3

This gene has 1 transcript (splice variant), 277 orthologues, 8 paralogues and is associated with 89 phenotypes. Biased expression in adrenal adult (RPKM 4.7), genital fat pad adult (RPKM 4.4) and 12 other tissues.

Summary

This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid Hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male Animals. Loss of function in female Animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]

Ar Products(1)

mRNA Protein Name
NM_013476.4 NP_038504.1 androgen receptor

Ar Protein Structure

Androgen_recep

Androgen_recep: cl27454 (5 - 439)

NR_DBD_AR

NR_DBD_AR: cd07173 (533 - 614)

NR_LBD_AR

NR_LBD_AR: cd07073 (651 - 896)

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  • 899 a.a.
Protein Preferred Names Protein Names

androgen receptor

dihydrotestosterone receptor

nuclear receptor subfamily 3 group C member 4

testicular feminization

Orthologs Information

Species Symbol Source ID
Homo sapiens Ar NCBI NCBI:367
Canis familiaris Ar NCBI NCBI:403588
Macaca fascicularis Ar NCBI NCBI:102117720
Canis lupus familiaris Ar NCBI
Susscrofa domestica Ar NCBI
Leporidae Ar NCBI
Rattus norvegicus Ar NCBI NCBI:24208
Macaca mulatta Ar NCBI NCBI:574293