Crbn - cereblon Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 297498

Summary

Enables transmembrane transporter binding activity. Involved in negative regulation of ion transmembrane transport; negative regulation of protein-containing complex assembly; and positive regulation of protein-containing complex assembly. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (Cereblon). [provided by Alliance of Genome Resources, Apr 2022]

Crbn Products (1)

mRNA Protein Name
NM_001015003.2 NP_001015003.1 protein cereblon
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19166841 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
16045448 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
16045448 RGD
involved in negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
16045448 RGD
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
16045448 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16045448 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein cereblon

Orthologs Information

Species Symbol Source ID
Homo sapiens Crbn NCBI NCBI:51185