AR - androgen receptor Gene
Also Known as KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
Species: Homo sapiens
About AR
This gene has 8 transcripts (splice variants), 276 orthologues, 8 paralogues and is associated with 136 phenotypes. Biased expression in liver (RPKM 12.9), endometrium (RPKM 10.8) and 13 other tissues.
Summary
The Androgen Receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
AR Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001348063.1 | NP_001334992.1 | androgen receptor isoform 4 |
| NM_001011645.3 | NP_001011645.1 | androgen receptor isoform 2 |
| NM_001348064.1 | NP_001334993.1 | androgen receptor isoform 5 |
| NM_001348061.1 | NP_001334990.1 | androgen receptor isoform 3 |
| NM_000044.6 | NP_000035.2 | androgen receptor isoform 1 |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
17277772 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
15572661 | GOA |
| located in nuclear speck |
IDA
IDA: Inferred from direct assay
|
23566155 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
15572661 | GOA |
| is active in plasma membrane |
IMP
IMP: Inferred from mutant phenotype
|
22031296 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
18468998 | GOA |
AR Protein Structure
Androgen_recep: Androgen receptor (6 - 449)
zf-C4: Zinc finger, C4 type (two domains) (558 - 626)
Hormone_recep: Ligand-binding domain of nuclear hormone receptor (692 - 877)
- 0
- 200
- 400
- 600
- 800
- 920 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
androgen receptor |
|
AR Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
AR | P10275 | BTG2 | Homo sapiens | P78543 | 21172304 | |
|
Intra
|
AR | P10275 | PARK7 | Homo sapiens | Q99497 | 17510388 | |
|
Intra
|
AR | P10275 | PARK7 | Homo sapiens | Q99497 | 17510388 | |
|
Intra
|
AR | P10275 | PARK7 | Homo sapiens | Q99497 | 17510388 | |
|
Intra
|
AR | P10275 | JMJD1C | Homo sapiens | Q15652 | 33640491 | |
|
Intra
|
AR | P10275 | KDM5D | Homo sapiens | Q9BY66-3 | 27185910 | |
|
Cross
|
AR | P10275 | Foxo1 | Mus musculus | Q9R1E0 | 17202144 | |
|
Cross
|
AR | P10275 | Foxo1 | Mus musculus | Q9R1E0 | 17202144 | |
|
Cross
|
AR | P10275 | Foxo1 | Mus musculus | Q9R1E0 | 17202144 | |
|
Intra
|
AR | P10275 | SMAD1 | Homo sapiens | Q15797 | 17183365 | |
|
Intra
|
AR | P10275 | DDC | Homo sapiens | P20711 | 12864730 | |
|
Intra
|
AR | P10275 | DDC | Homo sapiens | P20711 | 12864730 | |
|
Intra
|
AR | P10275 | FOXH1 | Homo sapiens | O75593 | 16120611 | |
|
Intra
|
AR | P10275 | RNF6 | Homo sapiens | Q9Y252 | 19345326 | |
|
Intra
|
AR | P10275 | NSD2 | Homo sapiens | O96028 | 19481544 | |
|
Intra
|
AR | P10275 | NSD2 | Homo sapiens | O96028 | 19481544 | |
|
Intra
|
AR | P10275 | IFI16 | Homo sapiens | Q16666 | 16494870 | |
|
Intra
|
AR | P10275 | GSN | Homo sapiens | P06396 | 19574450 | |
|
Intra
|
AR | P10275 | GSN | Homo sapiens | P06396 | 19574450 | |
|
Intra
|
AR | P10275 | PRDX1 | Homo sapiens | Q06830 | 17909037 | |
|
Intra
|
AR | P10275 | PRDX1 | Homo sapiens | Q06830 | 17909037 | |
|
Intra
|
AR | P10275 | CCND1 | Homo sapiens | P24385 | 16461912 | |
|
Intra
|
AR | P10275 | MDM2 | Homo sapiens | Q00987 | 18332867 | |
|
Intra
|
AR | P10275 | MAK | Homo sapiens | P20794 | 16951154 | |
|
Intra
|
AR | P10275 | MAK | Homo sapiens | P20794 | 16951154 | |
|
Intra
|
AR | P10275 | FOXA1 | Homo sapiens | P55317 | 23260764 | |
|
Intra
|
AR | P10275 | FOXA1 | Homo sapiens | P55317 | 33640491 | |
|
Intra
|
AR | P10275 | FOXA1 | Homo sapiens | P55317 | 22722839 | |
|
Intra
|
AR | P10275 | HIF1A | Homo sapiens | Q16665 | 17426252 | |
|
Intra
|
AR | P10275 | KAT7 | Homo sapiens | O95251 | 10930412 | |
|
Intra
|
AR | P10275 | CTNNB1 | Homo sapiens | P35222 | 21885566 | |
|
Intra
|
AR | P10275 | CTNNB1 | Homo sapiens | P35222 | 10987273 | |
|
Intra
|
AR | P10275 | CTNNB1 | Homo sapiens | P35222 | 12588987 | |
|
Intra
|
AR | P10275 | CTNNB1 | Homo sapiens | P35222 | 21741601 | |
|
Intra
|
AR | P10275 | CTNNB1 | Homo sapiens | P35222 | 12588987 | |
|
Intra
|
AR | P10275 | ASH2L | Homo sapiens | Q9UBL3 | 33640491 | |
|
Intra
|
AR | P10275 | ASH2L | Homo sapiens | Q9UBL3 | 22722839 | |
|
Intra
|
AR | P10275 | KMT2A | Homo sapiens | Q03164 | 22722839 | |
|
Intra
|
AR | P10275 | KMT2A | Homo sapiens | Q03164 | 33640491 | |
|
Intra
|
AR | P10275 | KMT2A | Homo sapiens | Q03164 | 33640491 | |
|
Intra
|
AR | P10275 | DAXX | Homo sapiens | Q9UER7 | 15572661 | |
|
Intra
|
AR | P10275 | DAXX | Homo sapiens | Q9UER7 | 15572661 | |
|
Intra
|
AR | P10275 | CASP8 | Homo sapiens | Q14790 | 17170703 | |
|
Intra
|
AR | P10275 | NCOA6 | Homo sapiens | Q14686 | 33640491 | |
|
Intra
|
AR | P10275 | ERG | Homo sapiens | P11308 | 22531786 | |
|
Intra
|
AR | P10275 | ERG | Homo sapiens | P11308 | 22722839 | |
|
Intra
|
AR | P10275 | SUMO1 | Homo sapiens | P63165 | 21242980 | |
|
Intra
|
AR | P10275 | SUMO1 | Homo sapiens | P63165 | 21242980 | |
|
Intra
|
AR | P10275 | CREBBP | Homo sapiens | Q92793 | 20541699 | |
|
Intra
|
AR | P10275 | CREBBP | Homo sapiens | Q92793 | 33640491 | |
|
Intra
|
AR | P10275 | NCOA2 | Homo sapiens | Q15596 | 33640491 | |
|
Intra
|
AR | P10275 | NCOA2 | Homo sapiens | Q15596 | 12588987 | |
|
Intra
|
AR | P10275 | NCOA2 | Homo sapiens | Q15596 | 15563469 | |
|
Intra
|
AR | P10275 | BRD4 | Homo sapiens | O60885-1 | 24759320 | |
|
Intra
|
AR | P10275 | BRD4 | Homo sapiens | O60885-1 | 24759320 | |
|
Intra
|
AR | P10275 | BRD4 | Homo sapiens | O60885-1 | 24759320 | |
|
Intra
|
AR | P10275 | BRD4 | Homo sapiens | O60885-1 | 24759320 | |
|
Cross
|
AR | P10275 | Siah2 | Mus musculus | Q06986 | 23518348 | |
|
Cross
|
AR | P10275 | Siah2 | Mus musculus | Q06986 | 23518348 | |
|
Intra
|
AR | P10275 | KMT2D | Homo sapiens | O14686 | 22722839 | |
|
Intra
|
AR | P10275 | KMT2D | Homo sapiens | O14686 | 33640491 |
Recombinant AR Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P72088 | Androgen receptor Protein, Human (His-SUMO, Myc) | P10275-1 (D551-T919) | ≥ 90%, as determined by reducing SDS-PAGE. |
AR Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80014 | Androgen receptor Antibody (YA620) | WB | Human |
| HY-P86132 | Androgen Receptor Antibody (YA5824) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Varicocele |
|
|
| Amelogenesis Imperfecta |
|
|
| Autism |
|
|
| Autosomal Dominant Cerebellar Ataxia |
|
|
| Spinal Muscular Atrophy |
|
|
| Pre-Eclampsia |
|
|
| Female Breast Cancer |
|
|
| Vulvar Sebaceous Carcinoma |
|
|
| Breast Cancer |
|
|
| Withdrawal Disorder |
|
|
| X-Linked Monogenic Disease |
|
|
| Neurofibroma |
|
|
| Machado-Joseph Disease |
|
|
| Teeth Hard Tissue Disease |
|
|
| Breast Fibroadenoma |
|
|
| Hyperandrogenism |
|
|
| Nervous System Disease |
|
|
| Disorder Of Sexual Development |
|
|
| Premature Menopause |
|
|
| Ductal Carcinoma In Situ |
|
|
| Prostate Cancer |
|
|
| Breast Ductal Carcinoma |
|
|
| Alopecia |
|
|
| Ovarian Cancer |
|
|
| Oligospermia |
|
|
| Germ Cell Cancer |
|
|
| Androgen Insensitivity Syndrome |
|
|
| Premature Ejaculation |
|
|
| Breast Lobular Carcinoma |
|
|
| Prostate Small Cell Carcinoma |
|
|
| Endometrial Cancer |
|
|
| Prostate Carcinoma In Situ |
|
|
| Prostatitis |
|
|
| Polycystic Ovary Syndrome |
|
|
| Sweat Gland Cancer |
|
|
| Spinocerebellar Ataxia 1 |
|
|
| Cryptorchidism, Unilateral Or Bilateral |
|
|
| Male Reproductive System Disease |
|
|
| Angelman Syndrome |
|
|
| Non-Syndromic X-Linked Intellectual Disability 19 |
|
|
| Diabetes Mellitus |
|
|
| Prostatic Hyperplasia, Benign |
|
|
| Androgen Insensitivity, Partial |
|
|
| Infertility |
|
|
| Prostatic Hypertrophy |
|
|
| Neuromuscular Disease |
|
|
| Lacrimal Gland Squamous Cell Carcinoma |
|
|
| Colorectal Cancer |
|
|
| Apocrine Adenocarcinoma |
|
|
| Gynecomastia |
|
|
| Peripheral Nervous System Disease |
|
|
| Microphthalmia, Syndromic 13 |
|
|
| Prostate Calculus |
|
|
| Acne |
|
|
| Inguinal Hernia |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Prader-Willi Syndrome |
|
|
| Testicular Germ Cell Cancer |
|
|
| Asthma |
|
|
| Male Reproductive Organ Cancer |
|
|
| Pseudohermaphroditism |
|
|
| Adenosquamous Breast Carcinoma |
|
|
| Androgenic Alopecia |
|
|
| Spinal Disease |
|
|
| Hair Disease |
|
|
| Motor Neuron Disease |
|
|
| Hypospadias |
|
|
| Penis Agenesis |
|
|
| Apocrine Sweat Gland Neoplasm |
|
|
| Impotence |
|
|
| Retinitis Pigmentosa |
|
|
| X-Linked Recessive Disease |
|
|
| 17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency |
|
|
| Testicular Disease |
|
|
| Autism Spectrum Disorder |
|
|
| Vaginitis |
|
|
| Male Infertility |
|
|
| Sebaceous Adenocarcinoma |
|
|
| Endometrial Hyperplasia |
|
|
| Sexual Health Disorder |
|
|
| Combined Immunodeficiency |
|
|
| Spermatogenic Failure 4 |
|
|
| Spinal And Bulbar Muscular Atrophy, X-Linked 1 |
|
|
| Hypogonadism |
|
|
| Aromatase Excess Syndrome |
|
|
| 46,Xy Sex Reversal 9 |
|
|
| Alopecia, Androgenetic, 1 |
|
|
| Dentatorubral-Pallidoluysian Atrophy |
|
|
| Muscular Atrophy |
|
|
| Asperger Syndrome |
|
|
| Ovarian Disease |
|
|
| Male Reproductive Organ Benign Neoplasm |
|
|
| Eyelid Carcinoma |
|
|
| Salivary Gland Disease |
|
|
| Myopathy |
|
|
| Lipoid Congenital Adrenal Hyperplasia |
|
|
| Prostatic Adenoma |
|
|
| Pleomorphic Adenoma |
|
|
| Barrett Esophagus |
|
|
| Prostate Disease |
|
|
| Tonsil Cancer |
|
|
| Osteoporosis |
|
|
| 46,Xy Sex Reversal |
|
|
| Estrogen-Receptor Positive Breast Cancer |
|
|
| Comedo Carcinoma |
|
|
| Prostate Adenoid Cystic Carcinoma |
|
|
| Vulvar Apocrine Adenocarcinoma |
|
|
| Castleman Disease |
|
|
| Sweat Gland Disease |
|
|
| Paget Disease, Extramammary |
|
|
| Testicular Cancer |
|
|
| Severe Combined Immunodeficiency |
|
|
| Estrogen-Receptor Negative Breast Cancer |
|
|
| Castration-Resistant Prostate Carcinoma |
|
|
| Turner Syndrome |
|
|
| Gender Incongruence |
|
|
| Pleomorphic Adenoma Carcinoma |
|
|
| Spermatogenic Failure 8 |
|
|
| Lymph Node Carcinoma |
|
|
| Non-Syndromic X-Linked Intellectual Disability Arx-Related |
|
|
| Adenosquamous Carcinoma |
|
|
| Prostate Neuroendocrine Neoplasm |
|
|
| Oncocytic Breast Carcinoma |
|
|
| Complete Androgen Insensitivity Syndrome |
|
|
| Pulmonary Sclerosing Hemangioma |
|
|
| Prostate Leiomyoma |
|
|
| Non-Syndromic X-Linked Intellectual Disability 82 |
|
|
| Telogen Effluvium |
|
|
| Breast Carcinoma In Situ |
|
|
| Hypogonadotropic Hypogonadism |
|
|
| Salivary Gland Carcinoma |
|
|
| Leukemia, Acute Myeloid |
|
|
| Amelogenesis Imperfecta, Type Ig |
|
|
| Hypospadias 1, X-Linked |
|
|
| Sebaceous Gland Disease |
|
|
| Spermatogenic Failure |
|
|
| Hepatocellular Carcinoma |
|
|
| Prostatic Acinar Adenocarcinoma |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Non-Syndromic Posterior Hypospadias |
|
|
| Huntington Disease |
|
|
| Primary Cutaneous Amyloidosis |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | AR | RGD | RGD:2147 |
| Mus musculus | AR | MGD | MGI:88064 |
| Canis familiaris | AR | VGNC | VGNC:38023 |
| Felis catus | AR | VGNC | VGNC:67988 |
| Macaca mulatta | AR | VGNC | VGNC:103789 |
| Bos taurus | AR | VGNC | VGNC:26053 |
| Others | AR | NCBI |