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Cortisol Circadian Rhythm and Disease

Cellular Stress Chronic Inflammation Sleep Deprivation Metabolic Diseases

Cortisol circadian rhythm describes the time-organized pattern of glucocorticoid secretion generated by the hypothalamic-pituitary-adrenal (HPA) axis and coordinated with the circadian clock. Glucocorticoids have been investigated for more than 80 years, and modern work has established that their daily variation is superimposed on a faster ultradian rhythm of repeated hormonal pulses. The circadian system contains a central pacemaker in the suprachiasmatic nucleus (SCN) and peripheral clocks in tissues, while adrenal hormones act as strong rhythmic signals that help disseminate time information through the body. This framework has moved cortisol biology beyond static hormone concentration toward temporal dynamics, because altered rhythmicity is linked in the literature to neuropsychiatric, metabolic, immune, cardiovascular, and malignant disorders. The growing emphasis on rhythm-sensitive diagnosis, chronotherapy, and continuous or repeated cortisol profiling reflects the biological importance of preserving both the amplitude and timing of glucocorticoid signals[1][2][3].

The SCN controls HPA-axis activity and autonomic input to the adrenal gland, whereas the adrenal clock modulates responsiveness to adrenocorticotropic hormone. Cortisol then enters target cells and signals through the glucocorticoid receptor, while tissue clocks reciprocally shape glucocorticoid responsiveness. A central molecular interaction involves the CLOCK-BMAL1 heterodimer: CLOCK-BMAL1 helps maintain circadian rhythmicity and can regulate glucocorticoid receptor activity through receptor acetylation, creating a mechanism by which circulating cortisol and tissue sensitivity may become uncoupled. At the HPA-axis level, varying-amplitude glucocorticoid pulses arise from feed-forward and feedback interactions between pituitary and adrenal components, and cells decode this oscillating signal through glucocorticoid and mineralocorticoid receptors. Circadian clock proteins also intersect with inflammation: Cryptochrome and REV-ERB proteins modulate innate immune responses and regulate glucocorticoid receptor function, connecting cortisol timing to inflammatory and metabolic control[4][5][3][6].

Disease research increasingly uses these mechanisms to explain why timing can change biological outcomes. Disruption of adrenal glucocorticoid rhythms has been linked to neuropsychiatric, metabolic, immune, and malignant disorders, while disturbed clock-HPA coupling may produce obesity, metabolic syndrome, and cardiovascular disease by separating circulating cortisol from tissue glucocorticoid sensitivity. In the brain, glucocorticoid oscillations may be crucial for neural stem/progenitor-cell proliferation and adult hippocampal neurogenesis, and experimentally changing cortisol delivery patterns in humans alters emotional processing, sleep quality, attention, and working memory even when the total cortisol dose is unchanged. Cancer provides a direct mechanistic case: glioblastoma models show that daily glucocorticoids can promote or suppress tumor growth through glucocorticoid-receptor signaling depending on circadian time and the clock genes BMAL1 and CRY; disrupting glucocorticoid or vasoactive-intestinal-peptide timing slows tumor progression in experimental systems[2][5][7][8][9].

A key limitation is that many clinical measurements and replacement regimens still compress a dynamic endocrine signal into isolated concentrations or nonphysiological dosing schedules. Current evidence indicates that loss of pulsatility or circadian alignment can alter cellular, cognitive, metabolic, and disease-related outputs, yet the optimal rhythm for diagnosis or therapy remains incompletely defined across diseases and individuals. Future work should therefore integrate high-resolution cortisol profiling with tissue-clock biology, glucocorticoid-receptor sensitivity, and disease-specific endpoints. Chronotherapy is a particularly important translational direction: physiological replacement strategies that reproduce circadian and ultradian patterns, and time-of-day optimization of glucocorticoid or anticancer treatment, may improve efficacy while reducing rhythm-related disruption. Important priorities are defining clinically meaningful cortisol dysrhythmia, identifying molecular signatures of tissue glucocorticoid sensitivity, and directly testing whether restoration of temporal organization changes long-term disease outcomes[3][8][9].

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Cat. No. Product Name Information Application Publication
HY-14648 Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.
Exosomes   Glucocorticoid Receptor   SARS-CoV   Autophagy   Complement System   Mitophagy   Bacterial   Antibiotic   ADC Payloads  
Metabolic or Endocrine Disease   Prostate Cancer   Pancreatic Cancer   Viral Infection   Bacterial Infection   Fungal Infection   Pain   Autoimmune Disease   Digestive System Inflammation   Cardiovascular Disease   Non-Small Cell Lung Cancer   Lung Squamous Cell Carcinoma   Metastatic Breast Cancer   SARS-CoV-2 Infection   Lung Fibrosis  
402
HY-B2176B ATP dimagnesium
ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation. ATP dimagnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP dimagnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Bacterial Infection  
178
HY-108353A Isoprenaline hemisulfate
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.
Adrenergic Receptor  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
97
HY-B0468 Isoprenaline hydrochloride
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.
Adrenergic Receptor  
Obesity  
97
HY-N0583 Hydrocortisone
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Environmental Pollutants   Glucocorticoid Receptor   Endogenous Metabolite  
Breast Cancer   Prostate Cancer   Pancreatic Cancer   Pain   Immunosuppression  
92
HY-L026 Clinical Compound Library
New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication, such as lower risk and less investment. Clinical drugs have confirmed bioactivities, clear mechanisms and high safety that are suitable for drug repurposing. MCE owns a unique collection of 2,568 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc.

Drug Repurposing Series

90
HY-L007 Immunology/Inflammation Compound Library
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 8,643 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Signaling Pathway Targeting Libraries

89
HY-L017 Stem Cell Signaling Compound Library
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 2,931 compounds that can be used for stem cell regulatory and signaling pathway research.

Signaling Pathway Targeting Libraries

86
HY-L026P Clinical Compound Library Plus
New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication, such as lower risk and less investment. Clinical drugs have confirmed bioactivities, clear mechanisms and high safety that are suitable for drug repurposing. MCE owns a unique collection of 3,298 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc. Clinical Compound Library Plus, with powerful screening capability, further complements Clinical Compound Library (HY-L026) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Drug Repurposing Series

86
HY-L077 Anti-Pancreatic Cancer Compound Library
Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer. MCE offers a unique collection of 4,336 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

Disease Focused Libraries

85
HY-L091 Lipid Metabolism Compound Library
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 1,026 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Signaling Pathway Targeting Libraries

85
HY-L092 Glucose Metabolism Compound Library
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 1,777 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Signaling Pathway Targeting Libraries

85
HY-L046 Anti-Cardiovascular Disease Compound Library
Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 2,468 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Disease Focused Libraries

84
HY-L056 Terpenoids Library
Terpenoids, also known as isoprenoids, are the most numerous and structurally diverse natural products found in many plants. Terpenoids are divided into monoterpenes, sesquiterpenes, diterpenes, sesterpenes, and triterpenes depending on its carbon units. Several studies, in vitro, preclinical, and clinical have confirmed that this class of compounds displays a wide array of very important pharmacological properties in the fight against cancer, malaria, inflammation, and a variety of infectious diseases. Naturally occurring terpenoids provide new opportunities to discover new drugs with minimum side effects. MCE designs a unique collection of 784 terpenoid compounds that all come from natural products. MCE Terpenoids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Structure Classified Natural Product Libraries

84
HY-L059 Pyroptosis Compound Library
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 2,034 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Signaling Pathway Targeting Libraries

84
HY-L075 Anti-Lung Cancer Compound Library
Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 3,061 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Disease Focused Libraries

84
HY-L080 Targeted Therapy Drug Library
Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecular targets that are involved in the growth, progression, and spread of cancer. There are several different types of targeted therapy. The most common types are small-molecule drugs and monoclonal antibodies. Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells, while monoclonal antibodies are usually used for targets that are located outside the cells. Because of high specificity, low side effect and potent anticancer activity, targeted therapy has become the mainstream of new anti-tumor drugs. Various targeted therapies have been approved by FDA and used in the treatment of diseases. MCE carefully collects a unique of 106 targeted therapy drugs used in cancer treatment. MCE Targeted therapy drug library is a useful tool for the research of targeted therapy.

Disease Focused Libraries

84
HY-L114 Anti-inflammatory Traditional Chinese Medicine Active Compound Library
Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes. Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1,665 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Disease Focused Libraries Traditional Chinese Medicine Libraries

84
HY-L121 5-HT Receptor Compound Library
5-HT receptors, also called Serotonin receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. These receptors are now classified into seven families, 5-HT1–7, comprising a total of 14 structurally and pharmacologically distinct mammalian 5-HT receptor subtypes. The 5-HT receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens. MCE 5-HT Receptor Compound Library consists of 430 5-HT receptor inhibitors and activators, which can be used for neuropsychiatric disorders drugs discovery.

Signaling Pathway Targeting Libraries

84
HY-L146 Metabolic Enzyme Compound Library
Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc. MCE designs a unique collection of 4,407 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.

Signaling Pathway Targeting Libraries

84
HY-L149 Membrane Protein-targeted Compound Library
A membrane protein is a protein molecule that is attached to or associated with the membrane of a cell or an organelle. Membrane proteins can be classified into two groups based on how the protein is associated with the membrane: integral membrane proteins and peripheral membrane proteins. In humans, about 30% genome encodes membrane proteins. Membrane proteins perform a variety of functions vital to the survival of organisms, for example, signal transduction, molecules or ion transportation, enzymatic catalysis, and intercellular communication. Membrane proteins also play important roles in drug discovery. As reported, more than 60% of current drug targets are membrane proteins. MCE supplies a unique collection of 7,999 compounds targeting a variety of membrane proteins. MCE Membrane Protein-targeted Compound Library can be used for membrane protein-focused screening and drug discovery.

Signaling Pathway Targeting Libraries

84
HY-L151 PROTAC Library
PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy. MCE supplies a unique collection of 544 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

Compound Characteristic Classified Libraries

84
HY-L0116V Asinex Macrocycles for RNA Library
Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
83
HY-L034M Anti-Aging Compound Library Mini
Research has shown that drugs targeting aging pathways demonstrate promising potential in models of age-related diseases such as Alzheimer's disease, cardiovascular diseases, metabolic syndrome, osteoarthritis, and various malignancies. This suggests that intervening in the biological processes of aging may enable synergistic prevention and treatment of multiple chronic diseases. Against the backdrop of the gradual elucidation of core aging mechanisms-including cellular senescence, telomere attrition, epigenetic dysregulation, and chronic inflammation anti-aging research has shifted from traditional phenotypic interventions toward targeting key pathways that regulate biological age. The MCE Anti-Aging Compound Library Mini is precisely built upon this cutting-edge concept. It focuses on aging-related targets validated through genetic or functional studies, comprising 381 compounds designed to provide systematic research tools for aging biology and intervention strategy development. The library covers core mechanisms such as mTOR, SIRT, energy metabolism, clearance of senescent cells, optimization of mitochondrial function, and telomere maintenance. For each target, 1-5 compounds with clear activity and strong representativeness have been carefully selected, spanning the entire translational spectrum from preclinical tool molecules to clinically investigational drugs.

Disease Focused Libraries

83
HY-L074 Anti-Breast Cancer Compound Library
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 3,404 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Disease Focused Libraries

83
HY-L079 Anti-Blood Cancer Compound Library
Blood cancers, also called hematologic cancers, occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection and produce new blood cells. Most blood cancers start in the bone marrow, which is where blood is produced. There are three main types of blood cancers: leukemia, lymphoma and myeloma, which afflict millions of children and adults every year, and are often deadly. Some common blood cancer treatments include stem cell transplantation, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. As we begin to understand the key signaling pathways and molecular drivers of malignant transformation in haematological disorders, new treatment strategies will continue to be developed. MCE offers a unique collection of 4,333 compounds with identified and potential anti-blood cancer activity. These compounds target blood cancer’s major targets and signaling pathways. MCE anti-blood cancer compound library is a useful tool for anti-blood cancer drugs screening and other related research.

Disease Focused Libraries

83
HY-L085 Anti-Parkinson's Disease Compound Library
Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD. MCE offers a unique collection of 2,199 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Disease Focused Libraries

83
HY-L087 Anti-Obesity Compound Library
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 3,741 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Disease Focused Libraries

83
HY-L131 Osteogenesis Compound Library
Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health. Osteoblasts play important roles in the process of osteogenesis and prevention of osteonecrosis. Osteoblast formation and bone formation are regulated by hormones, growth factors, cytokines, etc. MCE offers a unique collection of 984 bone formation compounds with identified and potential inducing osteogenesis activity. MCE bone formation compound library is a useful tool for the study of bone disease drugs and pharmacology.

Signaling Pathway Targeting Libraries

83
HY-L171 Anti-Hematopathy Compound Library
Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs. MCE designs a unique collection of 4,388 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

Disease Focused Libraries

83
HY-L174 Macrophage Related Compound Library
Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 276 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L175 Inflammasomes related Compound Library
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-L178 Radioprotector Library
Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells. MCE designs a unique collection of 3,066 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.

Compound Characteristic Classified Libraries

83
HY-L189 Amino Acid Metabolism Compound Library
Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases. MCE designs a unique collection of 352 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.
83
HY-L203 Methylation Compound Library
Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation. MCE contains 351 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.
83
HY-L204 Lactic Acid Metabolic Compound Library
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 582 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.
83
HY-L208 Bile Acids Library
Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases. MCE included 62 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.
83
HY-L210 Anti-Rheumatic Arthritis Compound Library
Rheumatoid Arthritis (RA) is a autoimmune disease characterized by persistent joint inflammation. The pathology of RA includes immune cell infiltration, synovial lining proliferation, pannus formation, and the destruction of joint cartilage and bone, which is highly disabling. Due to long-term chronic inflammation, RA not only severely affects the quality of life of patients but can also damage multiple organs, leading to lung diseases, cardiovascular diseases, and malignant tumors. The pathogenesis of RA is complex, involving genetic, environmental, and immune factors. With the advancement of high-throughput screening technology, screening for compounds targeting JAK, CCR, MEK, MMP targets may contribute to the development of more effective drugs against Rheumatoid Arthritis (RA). MCE has collected 2,023 small molecule compounds with definite or potential anti-rheumatoid arthritis activity. This library is of significant value for researching the anti-RA drugs.
83
HY-L211 Human Hormone Compound Library
Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases. MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.
83
HY-L217 Mouse Metabolite Compound Library
Metabolic abnormalities lead to dysfunction of metabolic pathways and the accumulation or lack of metabolites, which are recognized hallmarks of the disease. The metabolite signature is closely related to the disease phenotype and is very useful for predicting the diagnosis and prognosis of the disease as well as monitoring treatment. Metabolites can be used as disease markers for diagnostic therapy. As the classic model of disease experiment in vivo, mice metabolites also play a role in disease diagnosis and mechanism research. MCE provides 330 mouse metabolites that can be used in disease research.

Metabolism Focused Libraries

83
HY-L227 Amino Acid Metabolite Compound Library
Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 195 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Metabolism Focused Libraries

83
HY-L239 Steroid Hormones Library
Steroid hormones (also known as steroidal hormones) are a class of tetracyclic aliphatic hydrocarbon compounds derived from cholesterol. Typical representatives of steroid hormones include cortisol, aldosterone, testosterone, estradiol, among others. These hormones serve diverse regulatory functions within the body. For instance, aldosterone helps maintain the homeostasis of extracellular fluid volume and circulating blood volume; testosterone and estradiol primarily promote the development and maturation of male and female reproductive organs and regulate reproductive functions. MCE designs a unique collection of 71 steroid hormones. This library can be used for research related to metabolic or immune diseases, investigations into the mechanisms of action of nuclear receptor signaling pathways, as well as identification and quantitative analysis in metabolomics studies.

Compound Characteristic Classified Libraries

83
HY-L250 Lactic Acid Metabolite Compound Library
In the progression of various diseases, metabolic reprogramming has emerged as a key hallmark. Lactate, as an important metabolic signaling molecule, is widely involved in tumorigenesis, immune regulation, and inflammatory responses. Particularly within the tumor microenvironment, the abnormal accumulation of lactate not only affects cellular energy metabolism but also promotes disease progression by modulating immune cell functions and mediating protein lactylation, thereby participating in epigenetic regulation and signaling networks. Therefore, systematic investigation of lactate metabolic pathways and their associated metabolites is of great significance for understanding disease mechanisms and developing novel therapeutic strategies. The MCE lactic acid metabolite compound library contains 61 compounds and is constructed around key metabolic pathways involving lactate production, transport, and utilization. This library systematically includes core intermediates from glycolysis, the tricarboxylic acid (TCA) cycle, and the lactate cycle. Focusing on disease-associated metabolic reprogramming, it is suitable for research in oncology, inflammation, and metabolic disorders. The library can be used to elucidate the roles of lactate in tumor microenvironment regulation, immune evasion, and epigenetic modifications (such as protein lactylation). In addition, it provides high-quality small-molecule resources for drug screening, facilitating the discovery of potential modulators targeting key enzymes (such as LDH) or transporters (such as MCTs) involved in lactate metabolism.

Signaling Pathway Targeting Libraries

83
HY-L252 Carbohydrate Metabolite Compound Library
Carbohydrate metabolism serves as a central hub for energy supply and biosynthesis in living organisms and plays a critical role in the onset and progression of various diseases. In recent years, studies have shown that tumor cells reprogram their energy metabolism through aerobic glycolysis (the Warburg effect) to support rapid proliferation. Immune cells also rely on specific carbohydrate metabolic pathways to regulate their activation and differentiation states, while disorders such as diabetes and metabolic syndrome arise directly from dysregulation of carbohydrate metabolism. In addition, enzymes and key metabolic nodes involved in carbohydrate metabolism have become important targets for drug discovery, and therapeutic strategies targeting glycolysis, the pentose phosphate pathway, and energy metabolism are continuously advancing the treatment of cancer and metabolic diseases. Therefore, systematic analysis of carbohydrate metabolic networks and their associated metabolites is of great significance for elucidating disease mechanisms and developing novel therapeutic approaches. The MCE Carbohydrate Metabolism Metabolite Library is constructed based on classical carbohydrate metabolic pathways and contains 76 metabolites. It systematically integrates key metabolic networks, including glycolysis, the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle, monosaccharide metabolism, and sugar acid interconversions. The library comprehensively covers core metabolic nodes from glucose uptake and utilization to energy production and biosynthesis, while also incorporating important upstream and downstream intermediates. It enables accurate representation of intracellular metabolic flux dynamics and is well suited for applications such as metabolic flux analysis, target validation, and mechanistic studies. Furthermore, it provides robust support for multi-omics integration and the development of precision intervention strategies.
83
HY-L263 Energy Metabolites Library
Energy metabolism is the most fundamental biochemical process in living organisms, encompassing glycolysis, the TCA cycle, oxidative phosphorylation, the pentose phosphate pathway, and fatty acid oxidation. These core pathways directly regulate cell survival, proliferation, differentiation, and apoptosis. Dysregulation of energy metabolism is closely linked to major diseases including cancer, diabetes, obesity, cardiovascular diseases, neurodegenerative disorders, and ischemia‑reperfusion injury. Targeting these metabolic pathways has become a frontier in drug discovery and mechanistic research. The MCE Energy Metabolite Compound Library features 89 structurally defined small‑molecule compounds. It covers energy substrates, pathway intermediates, coenzymes and redox carriers, nucleotide derivatives, and microenvironmental modulators. This library is applicable to research areas including tumor metabolism, insulin resistance, mitochondrial dysfunction, oxidative stress, neuroprotection, and cardiometabolic diseases, providing a high‑quality tool for mechanistic studies, biomarker discovery, and high‑throughput drug screening.

Signaling Pathway Targeting Libraries

83
HY-L265 Cholesterol Metabolism Compound Library
Cholesterol is a crucial lipid that maintains cell membrane structure, serves as a precursor for the synthesis of steroid hormones and bile acids, and plays an important role in cell signal transduction and membrane function regulation. Intracellular cholesterol levels are precisely controlled by multiple processes, including synthesis, uptake, transport, esterification, storage, and efflux. Dysregulation of cholesterol metabolism is closely associated with diseases such as atherosclerosis, fatty liver disease, metabolic syndrome, and various cancers. The Cholesterol Metabolism Compound Library contains 558 compounds and focuses on cholesterol metabolism and homeostatic regulation. It provides an efficient tool for mechanistic studies of cholesterol metabolism and for drug discovery in metabolism‑related diseases.
83
HY-L923 Ion Channel Lead-like Compound Library
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields. MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Focused and target libraries

83
HY-13683 Mifepristone
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
Endogenous Metabolite   Progesterone Receptor   Glucocorticoid Receptor   NO Synthase   Autophagy  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Viral Infection   Depression   Pain  
80
HY-B1618 Corticosterone
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.
Glucocorticoid Receptor   Endogenous Metabolite   iGluR  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   SARS-CoV-2 Infection   Osteoarthritis  
71
HY-B0469 Medroxyprogesterone acetate
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
Progesterone Receptor   Androgen Receptor   Glucocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
35
HY-B0214 Prednisone
Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
Glucocorticoid Receptor   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Prostate Cancer   Viral Infection   Pain   Digestive System Inflammation   Cardiovascular Disease   Lung Fibrosis  
22
HY-B0260 Methylprednisolone
Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
Glucocorticoid Receptor   Autophagy   SARS-CoV   Bacterial  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Viral Infection   Coronavirus Infection   Bacterial Infection   Depression   Pain   Cardiovascular Disease   Non-Small Cell Lung Cancer  
21
HY-14415 SR8278
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease.
REV-ERB  
Metabolic or Endocrine Disease   Alzheimer's Disease  
17
HY-B1829A Dexamethasone phosphate disodium
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).
Glucocorticoid Receptor   TGF-β Receptor   Interleukin Related  
Neurological, Eye or Ear Disease   Ulcerative Colitis  
13
HY-B1779 Sucrose
Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
Environmental Pollutants   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
12
HY-D1168 Oil Red O
Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses.
Environmental Pollutants   Fluorescent Dye  
Metabolic or Endocrine Disease   Escherichia Coli Infection  
12
HY-17463 Prednisolone
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Prostate Cancer   Viral Infection   Pain   Lung Fibrosis  
12
HY-14414 GSK4112
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways.
REV-ERB   Apoptosis  
Metabolic or Endocrine Disease   Digestive System Disease   Digestive System Inflammation  
11
HY-N0421 Cinobufagin
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models.

Source: toad

Apoptosis  
Cancer   Neurological, Eye or Ear Disease   Digestive System Disease   Digestive System Inflammation  
9
HY-111372 Finerenone
Finerenone (BAY 94-8862) is a third-generation, selective, and orally active nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (> 500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Mineralocorticoid Receptor  
Cardiovascular Disease   Glucose Metabolism  
9
HY-16988A SR9011 hydrochloride
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
REV-ERB  
Breast Cancer  
8
HY-16988 SR9011
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
REV-ERB  
Breast Cancer  
8
HY-B0251 Eplerenone
Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV).
Mineralocorticoid Receptor   Endogenous Metabolite  
Breast Cancer   Bacterial Infection   Atherosclerosis   Hypertension   Myocardial Infarction   Heart Failure   Type 2 Diabetes   Insulin Resistance   Obesity   Hyperthyroidism   Chronic Kidney Disease  
8
HY-N0010 Geniposidic acid
Geniposidic acid is an orally active FXR modulator and SIRT6 activator. Geniposidic acid binds to the Ser332 and His447 sites on the FXR ligand-binding domain, thereby driving nuclear translocation, coactivator recruitment, and transcription of downstream bile acid and cholesterol metabolism-related genes. Geniposidic acid improves metabolic dysfunction-related fatty liver disease by activating the SIRT6 signaling pathway. Geniposidic acid inhibits inflammation and modulates gut microbiota to alleviate colitis. Geniposidic acid can be used in research on drug-induced liver injury, inflammatory bowel disease, metabolic dysfunction-related fatty liver disease, and metabolic dysfunction-related steatohepatitis.
FXR   Sirtuin   TNF Receptor   Interleukin Related  
Metabolic or Endocrine Disease  
7
HY-13421 SR1001
SR1001 is a selective RORα and RORγt inverse agonist with Kis 172 and 111 nM, respectively.
REV-ERB   ROR  
Cancer   Inflammation or Immune System Disease  
7
HY-B1811 Vasopressin
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
Endogenous Metabolite  
Neurological, Eye or Ear Disease  
7
HY-B0561 Spironolactone
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca2+ channels to exert antihypertensive effects.
Mineralocorticoid Receptor   Androgen Receptor   Autophagy   Calcium Channel  
Prostate Cancer   Viral Infection   Glucose Metabolism   Parkinson's Disease   Hypertension  
7
HY-13580 Budesonide
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.
Glucocorticoid Receptor   ADC Payloads  
Cancer   Inflammation or Immune System Disease   Viral Infection   Pain  
7
HY-139414 Lysophosphatidylcholines
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.
Interleukin Related   p38 MAPK   ERK   Apoptosis  
Inflammation or Immune System Disease  
7
HY-108749 Olive oil
Olive oil (Cropure OL) is an oleaginous compound found in the fruit of the Olea europaea tree. Olive oil contains many phenolic components and exerts antioxidant activity. Olive oil exhibits hydroxyl radical scavenging, platelet aggregation inhibition and xanthine oxidase inhibitory activity. Olive oil can promote wound healing and relieve inflammation. Olive oil can be used for the research of inflammation, cancer, metabolic and cardiovascular disease, such as diabetic foot ulcers and inflammatory bowel disease.
Environmental Pollutants   Xanthine Oxidase  
Cancer   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease   Inflammatory Bowel Disease  
7
HY-W127737 Methylcobalamin hydrate
Methylcobalamin Hydrate is a coenzyme required for methionine biosynthesis. Vitamins (hematopoiesis). It acts as a histamine receptor, Alzheimer study. Methylcobalamin is also used in the research of peripheral neuropathy, diabetic neuropathy, and as an initial research for amyotrophic lateral sclerosis. It can be used to prevent or research pathologies caused by vitamin B12 deficiency, such as pernicious anemia.
Biochemical Assay Reagents  
6
HY-N0901A Corynoxine B
Corynoxine B is an alkaloid-based autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances α-synuclein (α-syn) clearance in Parkinson's disease mice.
α-synuclein  
Cancer   Parkinson's Disease  
6
HY-17461 Cortisone
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Pain   Cardiovascular Disease   Glucose Metabolism   SARS-CoV-2 Infection   Osteoarthritis  
6
HY-19939S VX-984
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium.
DNA-PK  
5
HY-113414 Deoxycorticosterone
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM. Deoxycorticosterone could acts as an immune stimulator in fish.
Endogenous Metabolite   Mineralocorticoid Receptor  
Inflammation or Immune System Disease  
5
HY-112173 Prolylleucine
Prolylleucine (Z-Pro-D-Leu) is a dipeptide containing branched-chain amino acids. Prolylleucine (Z-Pro-D-Leu) can affect the circadian rhythms and behaviour of animals.
Others  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
4
HY-115672 KS15
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity.
Cryptochrome  
Breast Cancer  
4
HY-16276 Osilodrostat
Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome (CS).
Mineralocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Cardiovascular Disease   SARS-CoV-2 Infection  
4
HY-17461A Cortisone acetate
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
3
HY-I0626 Cytosine
Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. Cytosine can be used in cancer research.
Endogenous Metabolite  
Cancer   SARS-CoV-2 Infection  
3
HY-108537 L 012 sodium salt
L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)).
Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease  
3
HY-P99575 Tarlatamab
Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the KDs of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the KDs of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research.

Species: Human

Notch  
Inflammation or Immune System Disease   Respiratory Disease   Small Cell Lung Cancer  
3
HY-D0150A (Z)-Thiazole Orange iodide
(Z)-Thiazole Orange iodide is an asymmetric cyanine dye whose fluorescence highly depends on the local environment.(Z)-Thiazole Orange iodide is essentially dark in solution; however, its fluorescence increases a thousandfold when (Z)-Thiazole Orange iodide is introduced into double-stranded DNA and RNA (dsDNA or dsRNA). The maximum absorption of Thiazole Orange in complex with DNA is 509 nm, and the maximum emission is 532 nm. Thiazole Orange solution is widely used for determining the percentage of reticulocytes in human peripheral blood with microscopy and flow cytometry.
Fluorescent Dye  
2
HY-P3609 CR 665
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain.
Opioid Receptor  
Depression   Pain  
2
HY-119506 KL044
KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.
Cryptochrome  
Metabolic or Endocrine Disease  
2
HY-134194 KL201
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues.
Cryptochrome  
Metabolic or Endocrine Disease  
2
HY-P2476 Peripheral Myelin P0 Protein (180-199), mouse
Peripheral Myelin P0 Protein (180-199), mouse, a neuritogenic peptide, is a purified component of murine peripheral nerve myelin.
Others  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
2
HY-113447 11-Dehydrocorticosterone
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast.
Endogenous Metabolite  
Metabolic or Endocrine Disease   Cardiovascular Disease  
2
HY-B1438 Canrenone
Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
Mineralocorticoid Receptor  
Cardiovascular Disease  
2
HY-148711 STL1267
STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1.
REV-ERB  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
2
HY-108468 KL001
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis.
Cryptochrome  
Metabolic or Endocrine Disease  
2
HY-B1472 Deoxycorticosterone acetate
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria.
Mineralocorticoid Receptor  
Metabolic or Endocrine Disease   Hypertension  
2
HY-P990222 Anti-Mouse/Rat IL-17A Antibody (17F3)
Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat IL-17A. Anti-Mouse IL-17A Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes.

Species: Mouse

Interleukin Related  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
2
HY-Y0808 Dimethyl succinate
Dimethyl succinate is an orally active cell permeable succinate analogue. Dimethyl succinate can disrupt the TCA cycle by elevating intracellular succinate levels, leading to reduced protein synthesis and impairs myogenic differentiation. Dimethyl succinate can induce apoptosis. Dimethyl succinate can decrease maximal cellular respiration and reserve capacity. Dimethyl succinate can rescue synapse loss in AD. Dimethyl succinate can be used for the researches of metabolic and neurological disease.
Environmental Pollutants   Apoptosis  
Metabolic or Endocrine Disease   Alzheimer's Disease  
2
HY-W001171 3-Hydroxyanthranilic acid
3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.3-hydroxyanthranilic acid has anti-inflammatory, neuroprotective, and lipid-lowering effects. 3-hydroxyanthranilic acid can be used for researches of cardiovascular diseases, tumors, and metabolic diseases.
Endogenous Metabolite  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Cardiovascular Disease  
2
HY-B1773A Sodium propionate
Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
Environmental Pollutants   Bacterial   PPAR   NO Synthase   Endogenous Metabolite   HSV   COX   Apoptosis   Autophagy   NF-κB  
Breast Cancer   Colorectal Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Bacterial Infection   Depression   Pain   Digestive System Inflammation   Alzheimer's Disease   Obesity   Rheumatoid Arthritis  
2
HY-P3641 Kisspeptin 13
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
GnRH Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-N8460 Cortisol sulfate
Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate is a specific ligand for intracellular transcortin.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-N1989 Bacoside A
Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na+/K+-ATPase, Ca2+-ATPase and Mg2+-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme.
Na+/K+ ATPase   CaMK   Apoptosis   Cholinesterase (ChE)   NO Synthase   NF-κB  
Glioblastoma   Parkinson's Disease  
1
HY-113422S Tetrahydrocorticosterone-d5
Tetrahydrocorticosterone-d5 is the d5-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
1
HY-N7832 Petunidin-3-O-glucoside chloride
Petunidin-3-O-glucoside chloride is a blood-brain barrier-penetrating tyrosinase inhibitor with an IC50 of 10.3 μM and a Ki of 9.0 μM. Petunidin-3-O-glucoside also acts as an α-glucosidase inhibitor with an IC50 of 218.2 µM. Petunidin-3-O-glucoside chloride inhibits the SIRT3/p53-mediated mitochondrial pathway and the PI3K/Akt-ERK pathway, suppresses glycolysis, and induces cell apoptosis. Petunidin-3-O-glucoside chloride scavenges ROS to exert antioxidant activity. It can be used in research related to glioblastoma multiforme, skin anti-aging and whitening, as well as obesity.
Tyrosinase   Glycosidase   Apoptosis   PI3K   Akt   ERK   Reactive Oxygen Species (ROS)   MDM-2/p53  
Neurological, Eye or Ear Disease   Ovarian Cancer   Glucose Metabolism  
1
HY-N8460A Cortisol sulfate sodium
Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate sodium is a specific ligand for intracellular transcortin.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-117147A GSK2945 hydrochloride
GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
REV-ERB   Cytochrome P450  
Metabolic or Endocrine Disease  
1
HY-P3641A Kisspeptin 13 TFA
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
GnRH Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
1
HY-N0008 Orcinol glucoside
Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases.
Wnt   p38 MAPK   mTOR   Keap1-Nrf2   TGF-β Receptor  
Depression   Obesity  
1
HY-A0070AG Liothyronine (GMP)
Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
Thyroid Hormone Receptor  
Cancer   Metabolic or Endocrine Disease  
1
HY-P99812 Ragifilimab
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab binds to and activates GITR on T cells, which stimulates the immune system to enhance its anti-tumor activity. Ragifilimab can be used for advanced or metastatic solid tumors research.

Species: Human

TNF Receptor  
Cancer   Inflammation or Immune System Disease  
1
HY-Z0478 (-)-Limonene
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture.
Bacterial   Antibiotic   CaMK  
Metabolic or Endocrine Disease   Bacterial Infection   Cardiovascular Disease   Parkinson's Disease  
1
HY-N0910 Notoginsenoside Ft1
Notoginsenoside Ft1 is an orally active bioactive saponin. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8+ T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca2+ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y12 receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an FXR antagonist to combat obesity and insulin resistance.
PI3K   mTOR   Akt   Apoptosis   p38 MAPK   ERK   Transmembrane Glycoprotein   Glutathione Reductase (GR)   Estrogen Receptor/ERR   Calcium Channel   Ferroptosis   G protein-coupled Bile Acid Receptor 1   FXR  
Lung Cancer   Breast Cancer   Colorectal Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Neurodegenerative Disease   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-15108G Purmorphamine (GMP)
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
Smo  
Cancer   Neurological, Eye or Ear Disease  
1
HY-B1183 Hydrocortisone acetate
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids.
Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Pain   Cardiovascular Disease  
1
HY-NP159 House Dust Mite Extract, from D.farinae
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation.
Mucin   Interleukin Related  
Allergic Asthma  
1
HY-P2543 Neuropeptide Y (3-36) (human, rat)
Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides[1].
Neuropeptide Y Receptor  
Neurological, Eye or Ear Disease   Cardiovascular Disease  
1
HY-P990210 Anti-Mouse/Human IL-7 Antibody (M25)
Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for researches on inflammation conditions such as airway inflammation.

Species: Human/Mouse

Interleukin Related  
Inflammation or Immune System Disease  
1
HY-106373A Adrenocorticotropic hormone TFA
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone TFA stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone TFA regulates cortisol and androgen production. Adrenocorticotropic hormone TFA can promote the development of spermatogenesis. Adrenocorticotropic hormone TFA can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone TFA can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome.
Androgen Receptor   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease   Gout  
1
HY-D1244 CO probe 1
CO probe 1 (probe 2) is a highly efficient fluorescent CO probe (Ex=493 nm) with an allyl ether reaction site. In the presence of PdCl₂, CO reduces Pd2+ to Pd0, triggering a Tsuji-Trost reaction that removes the allyl protecting group, releases fluorescein, and generates a significant fluorescence signal. CO probe 1 has high selectivity, rapid response (fluorescence enhancement of 150 times within 20 minutes), and low cytotoxicity, and can be used for real-time imaging of CO in living cells. CO probe 1 may be used to study pathological mechanisms involving CO signaling regulation, such as inflammation, vascular disease, or cancer.
Fluorescent Dye  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
1
HY-148764 M47
M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer.
Molecular Glues   Cryptochrome   Apoptosis  
Cancer   Digestive System Disease   Digestive System Inflammation  
1
HY-P990806 Anti-Mouse CD20 Antibody (MB20-11)
Anti-Mouse CD20 Antibody (MB20-11) is a kind of mouse IgG2c antibody inhibitor, targeting to CD20. Anti-Mouse CD20 Antibody (MB20-11) can deplete mature B cells in lymphoid tissues. Anti-Mouse CD20 Antibody (MB20-11) can be used for the researches of cancer, immunology and metabolic Disease, such as lymphoma and diabetes.

Species: Mouse

CD20  
Cancer   Metabolic or Endocrine Disease   Blood Disease  
1
HY-125527 Resolvin D1
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.
Endogenous Metabolite  
Inflammation or Immune System Disease  
1
HY-Y1147 Diethyl maleate
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].
Biochemical Assay Reagents  
1
HY-106373 Adrenocorticotropic hormone
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone regulates cortisol and androgen production. Adrenocorticotropic hormone can promote the development of spermatogenesis. Adrenocorticotropic hormone can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome.
Androgen Receptor   Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease   Gout  
1
HY-148765 CLK8
CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms.
Cryptochrome  
Cancer   Metabolic or Endocrine Disease  
1
HY-W012734 L-Pipecolic acid
L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
1
HY-W013215 Adrenic acid
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a naturally polyunsaturated fatty acid in the adrenal gland, brain, kidney, and vasculature. Adrenic Acid can regulate the vascular tone in arteries of the adrenal cortex. Adrenic Acid also is an inflammation enhancer in non-alcoholic fatty liver disease.
Endogenous Metabolite  
Digestive System Disease   Digestive System Inflammation  
1
HY-N0583R Hydrocortisone (Standard)
Hydrocortisone (Standard) is the analytical standard of Hydrocortisone. This product is intended for research and analytical applications. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Breast Cancer  
1
HY-P83673 Cortisol Antibody
Cortisol Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cortisol.

Host: Mouse; Reactivity: Species independent

Polyclonal Antibodies Primary Antibodies

1
HY-K0304 Human CD3+ T Cells Negative Selection Kit

MCE Human CD3+ T Cells Negative Selection Kit is designed for the isolation of CD3+ T cells from human peripheral blood mononuclear cells (PBMC).

Cell Biology Cell Isolation

1
HY-K0351 Human CD8+ T Cells Negative Selection Kit

MCE Human CD8+ T Cells Negative Selection Kit is designed to isolate CD8+ T cells from human peripheral blood mononuclear cells (PBMCs).

Cell Biology Cell Isolation

1
HY-K0352 Human CD4+ T Cells Negative Selection Kit

MCE Human CD4+ T Cells Negative Selection Kit is designed to isolate CD4+ T cells from human peripheral blood mononuclear cells (PBMCs).

Cell Biology Cell Isolation

1
HY-K3012 N-2 Supplement (100×), Sterile

This product is serum-free and supports cell growth and survival. It has been associated with the growth and expression of neuroblastoma, and with post-mitotic neuronal survival and expression in primary cultures of both the peripheral nervous system (PNS) and central nervous system (CNS). This product is formulated with water-for-injection. The 5 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cell Biology Cell Culture Cell Culture Supplements

1
HY-P11274 Zenagamtide
Zenagamtide (Amycretin; NN 9487) is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases.
Amylin Receptor   GCGR   Insulin Receptor  
Metabolic or Endocrine Disease  
/
HY-18719S Endoxifen-d5 (Z-isomer)
Endoxifen-d5 (Z-isomer) is the deuterated-labeled Endoxifen (Z-isomer methanesulfonate) (HY-18719H). Endoxifen-d5 Z-isomer is an orally active selective PKCβ1 inhibitor with an IC50 of 360 nM against human PKCβ1. It also acts as an estrogen receptor modulator and antiestrogen. Endoxifen-d5 Z-isomer binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen-d5 Z-isomer inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. It can be used in research related to ER+ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors
PKC   Estrogen Receptor/ERR   PI3K   Akt   mTOR   Apoptosis   Reactive Oxygen Species (ROS)  
Breast Cancer   Melanoma   Glioblastoma  
/
HY-13526G YO-01027 (GMP)
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor.
Notch   γ-secretase  
Cancer  
/
HY-12186G 3-Deazaneplanocin A hydrochloride (GMP)
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor.
Histone Methyltransferase   Orthopoxvirus  
Cancer   Infection  
/
HY-B0672S Estradiol valerianate-d9
Estradiol valerianate-d9 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
Isotope-Labeled Compounds   Estrogen Receptor/ERR  
Cancer   Metabolic or Endocrine Disease  
/
HY-P11674 Zantrutide
Zantrutide is a glucagon, gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Zantrutide can be used for the study of metabolic diseases.
GLP Receptor  
Metabolic or Endocrine Disease  
/
HY-P992345 DS002
DS002 is a human monoclonal antibody targeting NGF/bNGF, with an IC50 of 6.60 nM against human NGF, 1.98 nM against rat NGF, and 8.46 nM against mouse NGF. DS002 blocks NGF-TrkA binding, interrupts pain signal transduction, inhibits TrkA-mediated downstream signaling pathways, and alters aromatic amino acid metabolic pathways. DS002 inhibits cancer cell proliferation. DS002 exerts a preventive effect on Paclitaxel-, Cisplatin- and Vincristine-induced peripheral neuropathy in rats. DS002 can be used in studies related to chronic pain and chemotherapy-induced peripheral neuropathy.

Species: Human

Trk Receptor  
Pain  
/
HY-113422S2 Tetrahydrocorticosterone-d3-1
Tetrahydrocorticosterone-d3-1 is the d3-1-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-172439S Simedeutirom
Simedeutirom is the agonist for thyroid hormone beta receptor (THRβ) and can be used for researchs of metabolic diseases, such as obesity and diabetes mellitus.
Isotope-Labeled Compounds   Thyroid Hormone Receptor  
Metabolic or Endocrine Disease  
/
HY-P991552 AFM15
AFM15 is a humanized monoclonal antibody inhibitor targeting CD3E. AFM15 can be used to study metabolic and immune system diseases, such as type 1 diabetes and inflammatory bowel disease (IBD).

Species: Human

CD3  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N20162 Peonyflower extract
Peonyflower extract is an extract from the peony (Paeonia) plant and can be used in research on various metabolic diseases.
Others  
Metabolic or Endocrine Disease  
/
HY-P3543 T-kinin
T-kinin (Ile-Ser-bradykinin) is a peptide containing bradykinin. T-kinin can be used for the research of inflammation.
Bradykinin Receptor  
Infection   Inflammation or Immune System Disease  
/
HY-B0114S1 Oxcarbazepine-d4-1
Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
Isotope-Labeled Compounds   Sodium Channel   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-149696 IR-Crizotinib
IR-Crizotinib is a NF-κB-inducing kinase (NIK) inhibitor that crosses the blood-brain barrier and fluorescently localizes intracranial glioblastoma (GBM) in mice (IC50=3.381 μM). IR-Crizotinib is conjugated from the near-infrared dye IR-786 and the NF-κB-inducing kinase (NIK) inhibitor Crizotinib. IR-Crizotinib can effectively inhibit the growth and invasion of glioma in vitro and in vivo and can be used in cancer research.
NF-κB  
/
HY-137474 Purpurin 18 methyl ester
Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death.

Source: sponge Stelletta clavosa

Photosensitizer  
/
HY-N0608S Myrislignan-13C,d2
Myrislignan-13C,d2 is the 13C, d2 deuterated-labeled Myrislignan (HY-N0608). Myrislignan is a PI3K/AKT/NF-κB inhibitor that can cross the blood-brain barrier. Myrislignan exerts anticancer activity by inducing apoptosis and ferroptosis. Myrislignan inhibits the replication and invasion of Toxoplasma gondii; it induces reactive oxygen species (ROS) imbalance, autophagy, and the death of Toxoplasma gondii tachyzoites. Myrislignan inhibits mitochondrial function and ERK1/2 phosphorylation to improve ovariectomy-induced osteoporosis. Myrislignan can be used in studies related to gastric cancer, glioblastoma, osteoporosis, and toxoplasmosis.
Isotope-Labeled Compounds   NF-κB   PI3K   Akt   Apoptosis   Ferroptosis   Reactive Oxygen Species (ROS)   Autophagy   ERK  
Gastric Cancer   Glioblastoma   Toxoplasma Infection   Osteoporosis  
/
HY-N0421R Cinobufagin (Standard)
Cinobufagin (Standard) is the analytical standard of Cinobufagin. This product is intended for research and analytical applications. Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models.
Reference Standards   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P1582 ACTH (1-14)
ACTH (1-14) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.
Adrenergic Receptor  
Cancer  
/
HY-P5297 DOTA-CXCR4-L
DOTA-CXCR4-L is a CXCR4 targeting peptide. DOTA-CXCR4-L can be used in the study of cancers, including glioblastoma and triple-negative breast cancer. NODAGA-LM3 can be labeled with [68Ga]/[177Lu] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
Radionuclide-Drug Conjugates (RDCs)   CXCR  
Cancer  
/
HY-D3330 APC-Cy7
APC-Cy7 is an APC-tandem fluorochrome (allophycocyanin-cyanine 7) and degradable fluorochrome, with maximum absorption at ~650 nm, peak emission at 767 nm when excited by a 633 nm red laser, and cell-dependent degradation. APC-Cy7 undergoes time-dependent degradation (decoupling) when bound to peripheral blood leukocytes, leading to nonspecific APC channel signal, with degradation cell type-dependent. APC-Cy7 shows reduced degradation when immunolabeled cells have inhibited metabolic activity or are incubated with vitamin C. APC-Cy7 serves as a tandem fluorochrome in multiparametric flow cytometry for detection of leukocyte surface proteins when conjugated to specific antibodies (Ex/Em = 650 nm/778 nm).
Fluorescent Dye  
/
HY-113422S1 Tetrahydrocorticosterone-d3
Tetrahydrocorticosterone-d3 is the d3-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Isotope-Labeled Compounds   Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-B1895S Levodropropizine-d8
Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
Isotope-Labeled Compounds   Histamine Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-17461AR Cortisone acetate (Standard)
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P3539 Exendin-4 (3-39)
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis.
GCGR  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P10433 EGFRvIII peptide
EGFRvIII peptide is an EGFRvIII-derived epitope for binding to MHC I molecules. EGFRvIII peptide induces apoptosis, and causes specific immune responses against glioblastoma, especially in combination with Flagellin B.
Apoptosis  
Cancer  
/
HY-P992450 REGN6569
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001.

Species: Human

TNF Receptor  
Cancer  
/
HY-14930S Mirodenafil-d7
Mirodenafil-d7 (SK3530-d7) is the deuterium labeled Mirodenafil (HY-14930). Mirodenafil (SK3530) is an orally active, potent, reversible, and selective?phosphodiesterase?5 (PDE5)?inhibitor. Mirodenafil is a?glucocorticoid receptor?(GR)?modulator Mirodenafil activates the?Wnt/β-catenin?signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).
Isotope-Labeled Compounds   Apoptosis   Wnt   Phosphodiesterase (PDE)   Glucocorticoid Receptor   β-catenin  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D3432 WazaGaY-1
WazaGaY-1 is an aza-BODIPY derivative, functions as a NIR-I/NIR-II fluorescent contrast agent. WazaGaY-1 undergoes internalization into tumor cells predominantly via clathrin-coated pits. WazaGaY-1 can be used for the research of glioblastoma, ovarian carcinoma and melanoma (Ex/Em = 685/820 nm).
Fluorescent Dye  
Ovarian Cancer   Cancer Immunology   Immunotherapy for Melanoma   Glioblastoma  
/
HY-N8835 Cannabisin D
Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling.
p38 MAPK  
Neurological, Eye or Ear Disease  
/
HY-P991516 TB-402
TB-402, a human IgG4 anticoagulant monoclonal antibody, is a partial Factor VIII inhibitor. TB-402 has a prolonged antithrombotic effect. TB-402 can be used for the prevention of venous thromboembolism (VTE) after total knee replacement (TKR).

Species: Human

Factor VIII  
Blood or Cardio-cerebrovascular Disease  
/
HY-P10255 K90-114TAT
K90-114TAT is an inhibitor for EAG2-Kvβ2 interaction, and exhibits antitumor efficacy against glioblastomas.
Potassium Channel  
Cancer  
/
HY-B1540S Beclomethasone-d5
Beclomethasone-d5 is the deuterium labeled Beclometasone. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
Glucocorticoid Receptor  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-12519G Oltipraz (GMP)
Oltipraz (GMP) is Oltipraz (HY-12519) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Oltipraz has an inhibitory effect on HIF-1α activation. Oltipraz is a potent Nrf2 activator.
HIF/HIF Prolyl-Hydroxylase   HIV   Keap1-Nrf2   Parasite  
Cancer  
/
HY-N12744 2-O-trans-p-Coumaroylalphitolic acid
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity.
Glucocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-100596G AS1842856 (GMP)
AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1.
Autophagy  
Metabolic or Endocrine Disease  
/
HY-P2719 Fibronectin Type III Connecting Segment Fragment 1-25
Fibronectin Type III Connecting Segment Fragment 1-25 is a peptide that is responsible for melanoma cell adhesion, and plays an important role in development of the peripheral nervous system in chicken.
Integrin  
Neurological, Eye or Ear Disease  
/
HY-P10277 Palopegteriparatide
Palopegteriparatide (Transcon PTH) is a prodrug of parathyroid hormone PTH 1-34, which can maintain normal and stable calcium concentrations without the need for calcium and active vitamin D replacement. Palopegteriparatide can be used in research on hypoparathyroidism.
Others  
Metabolic or Endocrine Disease  
/
HY-184895 CM002
CM002 is a circadian clock activator. CM002 inhibits the lineage commitment and terminal differentiation of preadipocytes by activating the circadian clock, thereby blocking the adipogenesis process driven by Wnt signaling-mediated transcriptional induction. CM002 attenuates lipid storage in a clock-dependent manner via inhibition of the lipogenic program in mature adipocytes. CM002 enhances circadian clock output across various adipose depots in both lean and obese mice through BMAL1/CLOCK-dependent metabolic reprogramming, inhibits adipocyte development and hypertrophy, and improves insulin sensitivity. CM002 can be used in research on obesity and type 2 diabetes.
Cryptochrome   REV-ERB   Nuclear Hormone Receptor 4A/NR4A   FABP   PARP   Fatty Acid Synthase (FASN)   Wnt   β-catenin   Hormone-Sensitive Lipase (HSL)   PGC-1α   ROR   GLUT  
Type 2 Diabetes   Obesity  
/
HY-P990177 Anti-Mouse Notch4 Antibody (HMN4-14)
Anti-Mouse Notch4 Antibody (HMN4-14) is an anti-mouse Notch4 IgG monoclonal antibody. Anti-Mouse Notch4 Antibody (HMN4-14) reduces inflammation by restoring the expression of bispecific proteins. Anti-Mouse Notch4 Antibody (HMN4-14) can inhibit Th2/Th17 cell differentiation and improve Treg cell function. Anti-Mouse Notch4 Antibody (HMN4-14) can be used for research on inflammation conditions such as viral pneumonia and airway inflammation.

Species: Mouse

Notch   Influenza Virus  
Infection   Inflammation or Immune System Disease  
/
HY-D3347 DUPA-FITC
DUPA-FITC is a fluorescent reagent targeting PSMA, which specifically binds to prostate cancer cells expressing PSMA without non-specific binding to normal blood cells. DUPA-FITC can label PSMA-expressing prostate cancer cells in whole blood, followed by internalization and trafficking to acidic intracellular endosomes, during which the fluorescence is quenched. When combined with flow cytometry and density gradient centrifugation enrichment, DUPA-FITC enables quantitative analysis of circulating tumor cells in peripheral blood samples from prostate cancer patients.
Fluorescent Dye  
Prostate Cancer  
/
HY-P4098 SynB1
SynB1 is a cell-penetrating peptide with blood-brain barrier permeability, derived from the antimicrobial peptide Protegrin 1. SynB1 enhances the cellular uptake efficiency and cytoplasmic localization level of conjugated constructs. SynB1 can be used in studies related to rabies and glioblastoma.
Others  
Glioblastoma   Rabies Virus Infection  
/
HY-P4971 C5a Anaphylatoxin (human)
C5a Anaphylatoxin (human) is a pro-inflammatory peptide and a leukocyte chemoattractant. C5a Anaphylatoxin (human) can be used to study inflammation and immunity, such as allergic asthma.
Complement System  
Inflammation or Immune System Disease  
/
HY-P11196 Allatostatin C
Allatostatin C (AstC) is a neuropeptide that suppresses gonadotropin production. Allatostatin C generates oogenesis rhythm by regulating juvenile hormone and vitellogenesis indirectly via insulin signaling. Allatostatin C can be used for neurological research.
Others  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P3990 Coibamide A
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.
VEGFR   Autophagy   Apoptosis  
/
HY-B0672S1 Estradiol valerianate-d4
Estradiol valerianate-d4 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
Isotope-Labeled Compounds   Estrogen Receptor/ERR  
Cancer   Metabolic or Endocrine Disease  
/
HY-P990809 Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection.

Species: Mouse

TNF Receptor  
Cancer   Infection   Inflammation or Immune System Disease  
/
HY-180396 Ikarisoside B
Ikarisoside B is a potent and selective Organic cation transporter 1 (OCT1) inhibitor with an IC50 of 11.18 μM. Ikarisoside B shows selectivity over OCT2 (IC50 = 56.54 μM). Ikarisoside B can be used for the research of metabolic disease.
Others  
Metabolic or Endocrine Disease  
/
HY-D3169 IETDC
IETDC is a caspase 8-responsive fluorescent probe. IETDC is cleaved by activated caspase 8 to release D-cysteine, which then reacts with 6-hydroxy-2-cyanobenzothiazole (HCBT) ​​to form firefly luciferin in situ. IETDC must be used in conjunction with PCL-2 (HY-D3168) to detect the co-existence of hydrogen peroxide and caspase 8. IETDC is applicable to studies related to acute inflammation.
Fluorescent Dye   Caspase  
Inflammation or Immune System Disease  
/
HY-N4024 Hyptadienic acid
Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID50 value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation.
Others  
Inflammation or Immune System Disease  
/
HY-W127407 Glycerophospho-N-arachidonoyl ethanolamine
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.
Biochemical Assay Reagents  
/
HY-W665456 Fmoc-PNA-U-OH
Fmoc‑PNA‑U‑OH is a peptide nucleic acid monomer that can be used for the synthesis of peptide nucleic acids (PNAs). Fmoc‑PNA‑U‑OH exhibits specific binding to adenine, resistance to enzymatic degradation, and strong hybridization properties. Fmoc‑PNA‑U‑OH can be applied in research fields such as gene diagnosis, molecular biology, and antisense therapy.
Drug Intermediate  
/
HY-NP077A Phaseolus vulgaris Lectin-P
Phaseolus vulgaris Lectin-P is the protein form of Phytohemagglutinin before the separation and purification of Phytohemagglutinin-L (PHA-L) and PHA-E. Phaseolus vulgaris Lectin-P can be used to stimulate the proliferation of peripheral mononuclear cells, promote the production of certain cytokines and the expression of membrane surface proteins.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-NP0209 Hydrocortisone-OVA
Hydrocortisone-OVA is a conjugate of Hydrocortisone (HY-N0583) and OVA peptide. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Glucocorticoid Receptor  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B1812S3 Veratrole-d6
Veratrole-d6 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-125911R Gossypin (Standard)
Gossypin (Standard) is the analytical standard of Gossypin. This product is intended for research and analytical applications. Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study.
Reference Standards   NF-κB   Aurora Kinase   Ribosomal S6 Kinase (RSK)   Apoptosis   Bcl-2 Family   Caspase   Cryptochrome  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P5923 E70K
E70K is a CXCL8 C-terminal peptide with a substitution of glutamic acid (E) 70 with lysine (K). E70K can reduce neutrophil adhesion and migration during inflammation.
CXCR  
Inflammation or Immune System Disease  
/
HY-P1245A Neuropeptide SF (human) acetate
Neuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
CRFR  
/
HY-B0114S2 Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects.
Sodium Channel   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-120971 N-Decanoyl p-Nitroaniline
N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity.1 FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate anandamide (AEA). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. Exposure of DepNA to FAAH activity results in the release of the yellow colorimetric dye p-nitroaniline (ε=13,500 at 410 nm). This allows the fast and convenient measurement of FAAH activity using a 96 well plate spectrophotometer.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P4115 CooP
CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles.
FABP  
Cancer  
/
HY-10585AG Valproic acid sodium (GMP)
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.
Organoid   HDAC   Autophagy   Mitophagy   HIV   Notch   Apoptosis   Endogenous Metabolite  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P991210 Efzimfotase alfa
Efzimfotase alfa (ALXN-1850) is enzyme replacement therapy agent targeting the deficiency of tissue-nonspecific alkaline phosphatase (TNSALP). Efzimfotase alfa functions by hydrolyzing the substrates of TNSALP, reducing the concentrations of substrates such as inorganic pyrophosphate (PPi) and pyridoxal 5′-phosphate (PLP). Efzimfotase alfa is promising for research of hypophosphatasia (HPP).
Phosphatase  
Blood or Cardio-cerebrovascular Disease  
/
HY-P3952 (D-Trp8,D-Cys14)-Somatostatin-14
(D-Trp8,D-Cys14)-Somatostatin-14 is a Somatostatin synthetic analogue. (D-Trp8,D-Cys14)-Somatostatin-14 can be used for the research of metabolic related diseases.
Somatostatin Receptor  
Metabolic or Endocrine Disease  
/
HY-160266 THR-β agonist 7
THR-β agonist-1 (Example 2) is a THR-β agonist, with EC50 values of 52 nM and 1017 nM for THR-β and THR-α, respectively.
Thyroid Hormone Receptor  
Cancer   Metabolic or Endocrine Disease  
/
HY-P10656 Ac-DEVDD-TPP
Ac-DEVDD-TPP is a porphyrin derivative that can be converted into D-TPP by caspase-3 cleavage and laser irradiation. The formed porphyrin nanofibers can effectively induce Apoptosis and Pyroptosis. Ac-DEVDD-TPP has antitumor activity.
Apoptosis   Pyroptosis  
Cancer  
/
HY-D3485 Dexamethasone fluorescein
Dexamethasone fluorescein is a fluorescently labeled steroid conjugate that binds to glucocorticoid receptors. Dexamethasone fluorescein binds to glucocorticoid receptors. Dexamethasone fluorescein serves as a marker for evaluating the delivery of drugs via subconjunctival injection and intratympanic administration. Sustained transscleral diffusion is achieved when Dexamethasone fluorescein is delivered via fibrin sealant. Dexamethasone fluorescein can be used to investigate the binding and localization of glucocorticoid receptors.
Fluorescent Dye   Glucocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-P990262 Anti-Mouse CD8 Antibody (HB-129)
Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8+ T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD).

Species: Mouse

Transmembrane Glycoprotein  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B0311S1 Carbidopa-d3-1
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth.
Aryl Hydrocarbon Receptor   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-NP077B Phaseolus vulgaris Lectin-M
Phaseolus vulgaris Lectin-M is a sticky protein form of lectin. Phaseolus vulgaris Lectin-M is mainly used to stimulate the proliferation of peripheral mononuclear cells, promote the production of certain cytokines and the expression of membrane surface proteins 。
Biochemical Assay Reagents  
/
HY-W012389 5-Bromo-1,2-difluoro-3-methoxybenzene
5-Bromo-1,2-difluoro-3-methoxybenzene (5-Bromo-2,3-difluoroanisole) is a drug synthesis intermediate that can be used to synthesize a ligand of glucocorticoid receptor (GR).
Drug Intermediate  
/
HY-B0233S1 Isradipine-d6
Isradipine-d6 is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
Calcium Channel   Autophagy  
Neurological, Eye or Ear Disease  
/
HY-B1319S1 Pramocaine-d9 hydrochloride
Pramocaine-d9 (Pramoxine-d9) hydrochloride is the d9-labeled Pramocaine hydrochloride (HY-B1319). Pramocaine hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.
Isotope-Labeled Compounds   Sodium Channel  
Neurological, Eye or Ear Disease  
/
HY-B2162H Chondroitin sulfate (from fish)
Chondroitin sulfate (from fish), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate (from fish) reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
NO Synthase   Endogenous Metabolite   MMP  
Inflammation or Immune System Disease  
/
HY-182832 Skim Milk powder
Skim Milk powder (Dry skim milk) is an orally effective, dairy-derived non-fat milk solid powder. Skim Milk powder serves as a nutrient source in microbial culture media and can also be used for blocking procedures in WB assays. Skim Milk powder protects zebrafish sperm from oxidative stress, DNA damage, membrane disruption and morphological abnormalities during cryopreservation, and improves their survival rate. After undergoing high Maillard reaction during moist-heat storage, Skim Milk powder exhibits negative metabolic activities such as inhibiting GLP-1/GIP and promoting intestinal inflammation. Skim Milk powder can be used in studies related to intestinal inflammation, diabetes and obesity.
DNA/RNA Synthesis   GLP Receptor  
Glucose Metabolism   Inflammatory Bowel Disease   Obesity  
/
HY-10966G SB-590885 (GMP)
SB-590885 GMP is SB-590885 (HY-10966) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer.
Raf   Apoptosis  
Colorectal Cancer   Blood Disease  
/
HY-D3197 CDg16
CDg16 is a selective fluorescent dye targeting SLC18B1 (λabs/λem=458/544 nm) that is actively transported into lysosomal vesicles of activated macrophages independent of the endocytic pathway. CDg16 enables highly specific vesicle localization in live cells. CDg16 exhibits no cytotoxicity and accurately distinguishes activated M1 and M2 subsets from different origins. CDg16 shows low background staining in non-activated cells and normal organs, making it suitable for time-lapse imaging. In preclinical animal models of inflammatory sites, atherosclerotic plaques and liver inflammation, CDg16 allows visualization of activated macrophages. CDg16 can be used to study inflammation-related diseases and atherosclerosis.
Fluorescent Dye  
Atherosclerosis and Inflammation  
/
HY-P4063 Pegylated synthetic human c-peptide
Pegylated synthetic human c-peptide retains bioactivity comparable to that of natural (i.e. non-polyethylene glycolated) C-peptides and has a prolonged circulating residence time in plasma for use in diabetic peripheral neuropathy studies.
Others  
Metabolic or Endocrine Disease  
/
HY-113066S3 Guanosine 5'-diphosphate-13C10,15N5 dilithium
Guanosine 5'-diphosphate-13C10,15N5 (GDP-13C10,15N5) dilithium is 13C and 15N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
Isotope-Labeled Compounds   Endogenous Metabolite   Potassium Channel  
Inflammation or Immune System Disease  
/
HY-P992150 Altrakincept
Altrakincept is a recombinant hIL-4 receptor and IL-4 neutralizer. Altrakincept neutralizes endogenous IL-4, and prevents the decline of pulmonary function and acute asthma exacerbations after abrupt withdrawal of inhaled glucocorticoids.

Species: Human

Interleukin Related  
Pulmonary Disease   Asthma  
/
HY-126675G AS2863619 (GMP)
AS2863619 GMP is AS2863619 (HY-126675) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS2863619 is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets Stat5a-CDK8/19 to promote the differentiation of CD4+ T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects.
CDK   Apoptosis   TGF-beta/Smad   STAT  
Digestive System Disease   Periodontal Disease  
/
HY-N16556 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside
2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside (Compound 45) is a phenolic compound. 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside can be isolated from Shorea roxburghii. 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside can be used in the research of Cyclophosphamide (HY-17420)-induced peripheral neuropathy.
Others  
Nervous System Injury  
/
HY-171561G DOTAM-Maleimide triTFA (GMP)
DOTAM-Maleimide triTFA (GMP) is DOTAM-Maleimide triTFA (HY-171561) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAM-Maleimide triTFA is a bifunctional chelator.
Biochemical Assay Reagents  
/
HY-125567 Antileukinate
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
CXCR  
Inflammation or Immune System Disease  
/
HY-16900G Rolipram (GMP)
Rolipram GMP is Rolipram (HY-16900) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis.
Phosphodiesterase (PDE)   Epigenetic Reader Domain   Amyloid-β  
Depression   Glioblastoma Multiforme   Alzheimer's Disease   Multiple Sclerosis  
/
HY-P1160A Bay 55-9837 TFA
Bay 55-9837 TFA is a potent and highly selective agonist of VPAC2, with a Kd of 0.65 nM. Bay 55-9837 TFA may be a useful therapy for the research of type 2 diabetes.
GCGR  
Metabolic or Endocrine Disease  
/
HY-N15728 2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside
2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside (Compound 5) is an orally active chromone glycoside found in the roots of Rumex patientia. 2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related fields such as inflammation and metabolic diseases.
Others  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D3274 PE-Cy5
PE-Cy5 is a tandem fluorescent dye commonly used in flow cytometry, immunofluorescence, and cell biology research. It is formed by the covalent linkage of two fluorescent molecules, namely phycoerythrin and CY5. PE-Cy5 binds to human FcγRI (CD64), and this binding can be blocked by human pooled serum, anti-CD64 monoclonal antibodies targeting the ligand-binding region, or aggregated IgG. PE-Cy5 supports three-color flow cytometry analysis, and whole blood staining can partially reduce its non-specific binding (Ex/Em = 450-500 nm/665 nm).
Fluorescent Dye  
/
HY-141944S Cortisol sulfate-d4 sodium
Cortisol-21-sulfate-d4 (sodium) is the deuterium labeled Cortisol-21-sulfate.
Isotope-Labeled Compounds  
/
HY-P992040 HAIL-12
HAIL-12 (16G2) is anan anti-human Interleukin-12 (IL-12p70) monoclonal antibody. HAIL-12 inhibits IL-12-mediated proliferation of T cells from human peripheral blood mononuclear cells.

Species: Human

Interleukin Related  
/
HY-P991918 KHK2840
KHK2840 is a potent CD40 agonist with a Kd value of 0.485 nM for hCD40. KHK2840 delivers agonistic signals in tumor-bearing hCD40 transgenic mice and human peripheral blood B cells. KHK2840 upregulates CD80, CD86, CD95 and IL-12p70 expression. KHK2840 enhances antitumor efficacy of anti-PD-1 antibody and Paclitaxel (HY-B0015). KHK2840 can be used for the research of cancer, such as colon cancer and melanoma.

Species: Human

Transmembrane Glycoprotein   Interleukin Related  
Colorectal Cancer   Cancer Immunology   Immunotherapy for Melanoma  
/
HY-N19874 Mukurozioside Ia
Mukurozioside Ia is an acyclic sesquiterpene oligoglycoside found in the pericarps of Sapindus rarak. Mukurozioside Ia can be used in the study of metabolic diseases.
Metabolic or Endocrine Disease  
/
HY-131306B 2-Hexadecenoic acid
2-Hexadecenoic acid is a natural unsaturated fatty acid. It is ubiquitously present in various animal and plant tissues, especially adipose tissue and certain vegetable oils, such as macadamia nut oil. 2-Hexadecenoic acid has unique chemical properties that make it an important component of cell membranes and storage lipids, and participates in various metabolic processes such as lipid metabolism and inflammation. It's also been linked to potential health benefits, including improved insulin sensitivity and a lower risk of heart disease.
Biochemical Assay Reagents  
/
HY-15772GL Osimertinib (GMP Like)
Osimertinib (AZD-9291; Mereletinib) GMP Like is the GMP Like level of Osimertinib (HY-15772). GMP Like small molecules works appropriately as an auxiliary reagent for cell research manufacture. Osimertinib GMP Like is an inhibitor that selectively targets EGFRT790M and activated EGFR mutants. Osimertinib GMP Like exerts multiple anti-tumor mechanisms, including radiosensitization, induction of apoptosis and ferroptosis, as well as inhibition of cancer stemness. Osimertinib GMP Like suppresses EGFR nuclear translocation and downstream survival signaling pathways, significantly reduces cell viability and lipid droplet content, and also exerts synergistic effects with radiotherapy or specific targeted agents to effectively overcome drug resistance and radioresistance. Formulations of Osimertinib GMP Like modified with liposomes or iRGD enable sustained release, tumor-specific accumulation, and breakthrough of the blood-brain barrier limitation. Osimertinib GMP Like can be used in research related to radioresistant glioblastoma and non-small cell lung cancer.
EGFR   Apoptosis   Ferroptosis  
Cancer  
/
HY-P5373 Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2
Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 is a biological active peptide. (Structure-activity studies of thrombin receptor-tethered ligand SFLLRNP have revealed the importance of the Phe-2-phenyl group in receptor recognition and the replacement of the Phe-2 by para-fluorophenylalanine [(p-F)Phe] was found to enhance its activity)
Others  
/
HY-P11149 Human Defensin-5 (1-9)
Human Defensin-5 (1-9) is an orally active antimicrobial peptide. Human Defensin-5 (1-9) can inhibit metabolic disorders induced by Western-style diet (WSD) or Western-style diet with fructose (WSDF). Human Defensin-5 (1-9) enhances intestinal barrier function by upregulating the gene expression of ileal tight junction protein and mucins. Human Defensin-5 (1-9) can be used for the study of obesity and related metabolic diseases.
Bacterial  
Infection   Metabolic or Endocrine Disease  
/
HY-P992012 CA1001
CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.

Species: Human

Opioid Receptor  
Melanoma   Pain  
/
HY-159060 Coriolus Versicolor Extract
Coriolus Versicolor Extract is a biological response modifier (BRM) with anti-cancer and anti-migratory properties. Coriolus Versicolor Extract can also inhibit the expression of tumorigenic factors associated with inflammation and can be used in cancer research.
MMP   Interleukin Related   Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-N16394 4-Hydroxyscytalone
4-Hydroxyscytalone (Compound 3) is a microbial secondary metabolite. 4-Hydroxyscytalone can be isolated from the oak fungus Diplodia corticola. 4-Hydroxyscytalone has toxicity against Artemia salina with a LC50 of 90.6 μ/mL, but no significant antifungal activity. 4-Hydroxyscytalone can be used for cancer therapy research.

Source: Xylaria polymorpha

Endogenous Metabolite  
Cancer  
/
HY-15772G Osimertinib (GMP)
Osimertinib (AZD-9291; Mereletinib) GMP is the GMP level of Osimertinib (HY-15772). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Osimertinib GMP is an inhibitor that selectively targets EGFRT790M and activated EGFR mutants. Osimertinib GMP exerts multiple anti-tumor mechanisms, including radiosensitization, induction of apoptosis and ferroptosis, as well as inhibition of cancer stemness. Osimertinib GMP suppresses EGFR nuclear translocation and downstream survival signaling pathways, significantly reduces cell viability and lipid droplet content, and also exerts synergistic effects with radiotherapy or specific targeted agents to effectively overcome drug resistance and radioresistance. Formulations of Osimertinib GMP modified with liposomes or iRGD enable sustained release, tumor-specific accumulation, and breakthrough of the blood-brain barrier limitation. Osimertinib GMP can be used in research related to radioresistant glioblastoma and non-small cell lung cancer.
EGFR   Apoptosis   Ferroptosis  
Cancer  
/
HY-174267S ATX-IN-2
ATX-IN-2 (Compound 25) is an orally active and potent ATX inhibitor with an IC50 value of 3.27 nM. ATX-IN-2 reduces lysophosphatidic acid (LPA) secretion. ATX-IN-2 is promising for research of ATX-mediated diseases, such as inflammation, pulmonary fibrosis.
Phosphodiesterase (PDE)  
Inflammation or Immune System Disease  
/
HY-B0358AS Flunarizine-d8 dihydrochloride
Flunarizine-d8 dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
Sodium Channel   Calcium Channel   Dopamine Receptor   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease  
/
HY-14397G Indomethacin (GMP)
Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research.
Antibiotic   COX   Bacterial   Influenza Virus  
Inflammation or Immune System Disease  
/
HY-P991409 GSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. GSK2800528 can be used in inflammation and psoriasis research.

Species: Human

TNF Receptor  
Inflammation or Immune System Disease  
/
HY-P3103 PINT-87aa
PINT-87aa, an 87-amino acid (aa) peptide, is encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT). PINT-87aa directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. PINT-87aa suppresses glioblastoma cell proliferation in vitro and in vivo.
DNA/RNA Synthesis  
/
HY-17461S Cortisone-13C3
Cortisone-13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-P4976 TGF α (1-50) (rat)
TGF α (1-50) (rat) TGF alpha (1-50) (rat) is an anti-inflammatory peptide useful in the study of inflammation and immunity.
Biochemical Assay Reagents  
Inflammation or Immune System Disease  
/
HY-P991970 REGN3124
REGN3124 is a fully human antibody with binding to EGFRvIII. REGN3124 forms REGN3124-PBD via conjugation to pyrrolobenzodiazepine linker-payload SG-3249. REGN3124 can be used for the research of glioblastoma multiforme.

Species: Human

EGFR  
/
HY-17461S3 Cortisone-d2
Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P10562 BMV Gag-(7−25)
BMV Gag-(7 25) is an arginine-rich peptide with cell-penetrating ability. BMV Gag-(7 25) can be used in drug delivery and gene therapy research.
TMV  
/
HY-172836S GLP-1 receptor agonist 17-d3
GLP-1 receptor agonist 17-d3 (Compound 701) is the deuterium labeled GLP-1R agonist 17 (HY-148212). GLP-1R agonist 17 is a GLP-1 receptor agonist that can be used for the research of cardiovascular metabolic diseases.
GCGR  
Blood or Cardio-cerebrovascular Disease  
/
HY-P10287 Neuropeptide W-30 (human)
Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human) activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-B0835S Fenobucarb-d3
Fenobucarb-d3 is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals.
Isotope-Labeled Compounds   Apoptosis   Reactive Oxygen Species (ROS)   Caspase   Cholinesterase (ChE)  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P3778 γ-Bag cell peptide
γ-bag cell peptide is a peptide. γ-bag cell peptide is located near the N-terminus of the egg laying prohormone, the vesicle is released upon insulin stimulation. γ-bag cell peptide can be used for the research of the central and peripheral nervous systems.
Others  
Neurological, Eye or Ear Disease  
/
HY-P991573 Anti-EGFR Antibody (D2C7)
Anti-EGFR Antibody (D2C7) is a monoclonal antibody against EGFR. The recombinant immunotoxin D2C7-(scdsFv)-PE38KDEL constructed based on Anti-EGFR Antibody (D2C7) has antineoplastic activity in glioblastoma models.

Species: Human

EGFR  
Cancer  
/
HY-113217F BODIPY 480/508-cholesteryl oleate
BODIPY 480/508-cholesteryl oleate is a fluorescently tagged derivative of Cholesteryl oleate (HY-113217). BODIPY 480/508-cholesteryl oleate can be used to monitor lipid transport mechanisms in mammalian cells (Ex/Em = 480/508 nm).
Fluorescent Dye   Liposome  
Metabolic or Endocrine Disease  
/
HY-134192 TH301
TH301 is a Phenylpyrazole derivative. TH301 selectively stabilize CRY2. TH301 dose-dependently prolongs circadian period.
Drug Derivative   Cryptochrome  
/
HY-17461S4 Cortisone-d9
Cortisone-d9 (17-Hydroxy-11-dehydrocorticosterone-d9) is the deuterium labeled Cortisone (HY-17461). Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-D3168 PCL-2
PCL-2 is a reactive oxygen species (ROS)-responsive fluorescent probe. PCL-2 reacts with ROS to release 6-hydroxy-2-cyanobenzothiazole (HCBT), which then reacts with D-cysteine ​​to form firefly luciferin in situ. PCL-2 must be used in conjunction with IETDC (HY-D3169) to detect the co-existence of hydrogen peroxide and caspase 8. PCL-2 is applicable to studies related to acute inflammation.
Fluorescent Dye   Reactive Oxygen Species (ROS)  
Inflammation or Immune System Disease  
/
HY-B0347S1 Lacidipine-13C8
Lacidipine-13C8 is the deuterium labeled Lacidipine. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI).
Apoptosis   Caspase   Calcium Channel   Reactive Oxygen Species (ROS)  
Blood or Cardio-cerebrovascular Disease  
/
HY-D3153 PbQ
PbQ is a tubulin inhibitor (with an IC50 of 5 μM against goat tubulin) and a fluorescent probe for cuprous ions Cu (I). PbQ can penetrate the membrane of peripheral blood mononuclear cells, form a stable 1:1 complex with Cu+ ions, and exhibits low toxicity and good biocompatibility toward macrophage cell lines. In addition, PbQ promotes tubulin degradation and disrupts the microtubule network in lung epithelial cells without affecting actin. PbQ also possesses genotoxicity by forming DNA base adducts, and it can activate caspase-3 and apoptosis-related genes, induce loss of mitochondrial membrane potential, and trigger cell apoptosis. PbQ can be used in studies related to chronic obstructive pulmonary disease.
Apoptosis   Caspase   Microtubule/Tubulin  
/
HY-P10054 SGKtide
SGKtide is used as an SGK(Serum and glucocorticoid-inducible kinase) substrate.
Others  
/
HY-P5874 Myr-TAT-CBD3
Myr-TAT-CBD3 is CRMP2-CaV2.2 interaction inhibitor. Myr-tat-CBD3 can significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity induced in a rat model of postoperative pain. Myr-TAT-CBD3 can be used to study inflammation and postoperative pain.
Calcium Channel  
Inflammation or Immune System Disease  
/
HY-N19801 N-Palmitoyl-D-glucosamine
N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds MD-2 with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy.

Source: Pseudomonas aeruginosa

Toll-like Receptor (TLR)   NF-κB   Interleukin Related   TNF Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-163253S HSD17B13-IN-56-d3
HSD17B13-IN-56-D3 (Compound 169) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-56-D3 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI).
17β-HSD  
Metabolic or Endocrine Disease  
/
HY-P4040 Ac-D-DGla-LI-Cha-C
Ac-D-DGla-LI-Cha-C is a potent HCV protease inhibitor peptide. Ac-D-DGla-LI-Cha-C can be used for the research of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases.
HCV Protease  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-B0233S2 Isradipine-d7
Isradipine-d7 is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
Calcium Channel   Autophagy   Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P10110 retro-inverso TAT-Beclin 1 (D-amino acid)
retro-inverso TAT-Beclin 1 D-amino acid is has higher activity and resistance to proteolytic degradation in vivo compared to L-amino acids peptide. TAT-Beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice.
Autophagy  
Neurological, Eye or Ear Disease  
/
HY-N21629 Phanginin J
Phanginin J is a Cassane-type furanoditerpene found in the seeds of Caesalpinia sappan L. Phanginin J docks with the TRPV1 molecule and may inhibit nociceptive sensory signal transduction by antagonizing TRPV1. Phanginin J can be used in research related to chemotherapy-induced peripheral neuropathy (CIPN).
Drug Derivative   TRP Channel  
Neurological, Eye or Ear Disease  
/
HY-113344S2 16α-Hydroxyestrone-d3
16α-Hydroxyestrone-d3 (16αOHE-d3) is the deuterium labeled 16α-Hydroxyestrone (HY-113344). 16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease.
Isotope-Labeled Compounds   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-N0610S2 Cinnamic acid-d7
Cinnamic acid-d7 (3-Phenylacrylic acid-d7) is the deuterium labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
Isotope-Labeled Compounds   Endogenous Metabolite   Environmental Pollutants  
Cancer  
/
HY-P4413 (Des-Glu5)-ACTH (1-24) (human, bovine, rat)
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH; HY-106373). ACTH is a polypeptide tropic hormone produced by the anterior pituitary gland, regulating cortisol and androgen production.
Androgen Receptor  
Metabolic or Endocrine Disease  
/
HY-P4493 (Des-Ser3)-ACTH (1-24) (human, bovine, rat)
(Des-Ser3)-ACTH (1-24) (human, bovine, rat) is a peptide analog of the adrenocorticotropic hormone (ACTH). ACTH stimulates the production of cortisol.
Others  
/
HY-D3227 HOTN
HOTN is a hypochlorous acid (HClO) Fluorescent indicator. HOTN is oxidized by HClO, causing cleavage of its Py+-N+ moiety and a change in hydrophobicity, which in turn triggers aggregation-induced emission to generate a strong fluorescent signal. HOTN is used for in vivo imaging of inflammation and hepatocellular carcinoma, as these diseases typically result in high levels of HClO.
Fluorescent Dye  
Inflammation or Immune System Disease   Liver Cancer  
/
HY-B0114S3 Oxcarbazepine-d10
Oxcarbazepine-d10 (GP 47680-d10) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
Isotope-Labeled Compounds   Sodium Channel   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-N15307 Trigraecum
Trigraecum is a flavonoid compound found in Dracaena steudneri and Dalbergia cochinchinensis, exhibiting anti-inflammatory activity. It can inhibit the LPS (HY-D1056)-induced production of IL-1β, IL-2, GM-CSF, and TNF-α in human peripheral blood mononuclear cells. Trigraecum holds promise for research on inflammatory diseases.
Interleukin Related   TNF Receptor  
Inflammation or Immune System Disease  
/
HY-B0114S Oxcarbazepine-d4
Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
Isotope-Labeled Compounds   Sodium Channel   Apoptosis  
Cancer   Neurological, Eye or Ear Disease  
/
HY-P1558B ACTH (11-24) hexaacetate
ACTH (11-24) (hexaacetate) is a type of adrenocorticotropic hormone that can trigger cortisol secretion in bovine adrenal cortex cells.
Endogenous Metabolite  
/
HY-N18390 5-Methyltetrahydropteroyltri-L-glutamate
5-Methyltetrahydropteroyltri-L-glutamate is an amino acid derivative. 5-Methyltetrahydropteroyltri-L-glutamate is present in the dried extract of Allium sativum (Hisar Garlic No. 17). 5-Methyltetrahydropteroyltri-L-glutamate participates in the remethylation of homocysteine to methionine via cobalamin-independent methionine synthase. 5-Methyltetrahydropteroyltri-L-glutamate is a biomarker associated with altered one-carbon transfer reactions in glioblastoma. 5-Methyltetrahydropteroyltri-L-glutamate can be used in glioblastoma-related research.
Amino Acid Derivatives  
Glioblastoma  
/
HY-W011425A NTPO trisodium
NTPO trisodium is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO trisodium are abrogated by base excision repair (BER) but not nucleotide excision repair (NER).
Others  
Cancer  
/
HY-A0096R Iloprost (Standard)
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research.
Reference Standards   Prostaglandin Receptor   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-N12531 Molephantin
Molephantin is a blood-brain barrier permeable anti-glioblastoma compound. Molephantin induces ROS generation, leading to mitochondrial damage, Mitophagy flux blockage and Apoptosis induction. Molephantin can suppress the PI3K/Akt/mTOR signaling pathway. Molephantin demonstrates antitumor effects against glioblastoma.
Reactive Oxygen Species (ROS)   Mitochondrial Metabolism   Mitophagy   Apoptosis   PI3K   Akt   mTOR  
Glioblastoma  
/
HY-W767656 Dropropizine-d4
Dropropizine-d4 ((±)-Dropropizine-d4) is deuterium labeled Dropropizine. Dropropizine ((±)-Dropropizine) belongs to the phenylpiperazine group of organic compounds. Dropropizine is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
Isotope-Labeled Compounds   Others  
Neurological, Eye or Ear Disease  
/
HY-P10358A TAT-CBD3A6K acetate
TAT-CBD3A6K acetate, is a modified TAT-CBD3 peptide. TAT-CBD3A6K acetate reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K acetate shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-124329AS BS3 Crosslinker-d4 disodium
BS3 Crosslinker-d4 disodium is the deuterated-labeled BS3 Crosslinker disodium (HY-124329A). BS3 Crosslinker disodium is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker disodium "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker disodium can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
Cancer  
/
HY-141914S Cortisol-21-glucuronide-d4 sodium
Cortisol-21-glucuronide-d4 (sodium) is the deuterium labeled Cortisol-21-glucuronide.
Isotope-Labeled Compounds  
/
HY-B0468R Isoprenaline hydrochloride (Standard)
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma.
Reference Standards   Adrenergic Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-108537R L 012 sodium salt (Standard)
L 012 sodium salt (Standard) is the analytical standard of L 012 (sodium salt) (HY-108537). This product is intended for research and analytical applications. L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)).
Reactive Oxygen Species (ROS)   Reference Standards  
/
HY-P991677 Efmirenpase alfa
Efmirenpase alfa is an Fc-ENPP1 fusion protein (human IgG1 Fc domain linked to a modified human ENPP1). Efmirenpase alfa has prolonged half-life and enhanced receptor affinity compared with native human ENPP1. Efmirenpase alfa can be used as an enzyme replacement therapy for ENPP1 deficiency such as arterial calcification and hypophosphatemic rickets research.

Species: Human

Phosphodiesterase (PDE)  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-N12535 Tagitinin C
Tagitinin C is a sesquiterpenoid compound isolated from the Tithonia diversifolia. Tagitinin C has anticancer activity and can inhibit the proliferation of human glioblastoma U373 cells with an IC50 of 6.1 μg/mL. Tagitinin C can induce U373 cell death and be used in glioblastoma research.
Others  
Cancer  
/
HY-107737R 1,2-DLPC (Standard)
1,2-DLPC (Standard) is the analytical standard of 1,2-DLPC (HY-107737). This product is intended for research and analytical applications. 1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breaKdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.
Reference Standards   Liposome   Apoptosis   TNF Receptor   PPAR  
/
HY-P991958 GIGA-564
GIGA-564 is a fully human anti-CTLA4 IgG1 monoclonal antibody with a Kd of 9.8 nM. GIGA-564 binds to a unique epitope of CTLA-4, mediates FcR-dependent signaling pathways, depletes CTLA-4-highly-expressing regulatory T cells within tumors, and inhibits the proliferation of peripheral regulatory T cells. GIGA-564 exhibits anti-tumor activity in mouse models. GIGA-564 can be used for tumor research.

Species: Human

CTLA-4  
Cancer  
/
HY-105047 Cholyl-Lys-fluorescein
Cholyl-Lys-fluorescein is a fluorescent-labelled bile salt and a marker of hepatic biliary transporter function. Cholyl-Lys-fluorescein can be used for metabolic research.
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-B1811R Vasopressin (Standard)
Vasopressin (Standard) is the analytical standard of Vasopressin. This product is intended for research and analytical applications. Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
Endogenous Metabolite   Reference Standards  
Neurological, Eye or Ear Disease  
/
HY-P990846 Anti-Fy3 Antibody (MIMA-29)
Anti-Fy3 Antibody (MIMA-29) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Fy3. Anti-Fy3 Antibody (MIMA-29) binds to erythrocytes and induces RBC (red blood cells) clearance. Anti-Fy3 Antibody (MIMA-29) can be used for the research of metabolic disease .

Species: Human

Transmembrane Glycoprotein  
Metabolic or Endocrine Disease  
/
HY-B2176BR ATP dimagnesium (Standard)
ATP (dimagnesium) (Standard) is the analytical standard of ATP (dimagnesium). This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation.
Endogenous Metabolite   Reference Standards  
Inflammation or Immune System Disease  
/
HY-14397S2 Indometacin-d7
Indometacin-d7 is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research.
Bacterial   COX   Antibiotic   Influenza Virus   Isotope-Labeled Compounds  
Cancer   Inflammation or Immune System Disease  
/
HY-P990138 Anti-Monkey/Human CD20 Antibody (2H7)
Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to monkey/human CD20. Anti-Monkey/Human CD20 Antibody (2H7) specifically depletes B cells. Anti-Monkey/Human CD20 Antibody (2H7) can be used for the researches of inflammation and metabolic disease, such as diabetes and experimental autoimmune encephalomyelitis.

Species: Monkey/Human

CD20  
Metabolic or Endocrine Disease   Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
/
HY-157585S 21-Dehydro Budesonide-d8-1
21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies.
Isotope-Labeled Compounds   Glucocorticoid Receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-164893 ABBV-154
ABBV-154 is an anti-TNF antibody-drug conjugate (ADC). ABBV-154 is composed of the humanized antibody Adalimumab (HY-P9908) conjugated with a glucocorticoid receptor modulator (HY-137883). ABBV-154 can be used in studies of rheumatoid arthritis, Crohn's disease and polymyalgia rheumatica.
Antibody-Drug Conjugates (ADCs)   TNF Receptor   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-D2911 Pantetheine probe PP-3
Pantetheine probe PP-3 (Compound PP-3) is an alkynyl group connector probe. Pantetheine probe PP-3 selectively enriches and maps modification sites (e.g., Ser231 on DHRS2). Pantetheine probe PP-3 is promising for research of metabolic disorders (e.g., fatty acid synthesis dysregulation).
Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-W060216 N-Acetyl-DL-penicillamine
2-Acetamido-3-methyl-3-sulfanylbutanoic acid is an organic compound that belongs to the class of amino acids. It is a derivative of methionine, an essential amino acid commonly found in various foods. 2-Acetamido-3-methyl-3-sulfanylbutanoic acid contains a thiol group and an acetamido group at specific positions in the amino acid chain. It has various applications in the food industry, especially as a flavor enhancer and umami seasoning. Additionally, it has potential research utility in liver disease and other metabolic disorders.
Biochemical Assay Reagents  
/
HY-N9854 Icariside E4
Icariside E4 is an antinociceptive agent, and can be isolated from Tabebuia roseo-alba. Icariside E4 has peripheral analgesic activity by ATP-sensitive K+ channel-dependent mechanisms. Icariside E4 also has anti-oxidant, anti-Alzheimer and anti-inflammatory effects.
Potassium Channel  
Inflammation or Immune System Disease  
/
HY-B1779S5 Sucrose-13C6
Sucrose-13C6 is the 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-P992073 OpSCF
OpSCF (INS1148) is an antibody that specifically binds and inactivates inflammatory stem cell factor (SCF), blocks the positive feedback cycle of chronic inflammation, and aids tissue repair. OpSCF can be used for research related to asthma, pulmonary fibrosis, and interstitial lung disease.

Species: Human

Others  
Asthma  
/
HY-P11326 Ac-FR-AFC TFA
Ac-FR-AFC TFA is a fluorometric substrate for cathepsin L. Ac-FR-AFC TFA can be used for the research of glioblastoma.
Cathepsin   Fluorescent Dye  
Glioblastoma  
/
HY-B0233S Isradipine-d3
Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
Isotope-Labeled Compounds   Calcium Channel   Autophagy  
Neurological, Eye or Ear Disease   Blood or Cardio-cerebrovascular Disease  
/
HY-P992101 Aritinercept
Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus.

Species: Human

TNF Receptor   IFNAR   Interleukin Related  
Systemic Lupus Erythematosus  
/
HY-P3819 Delta (Phospho) Sleep Inducing Peptide
Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats.
Others  
Neurological, Eye or Ear Disease  
/
HY-122767 Romurtide
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and IL-6 in vitro.
Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P10302 GLP-1R/GIPR agonist-1
GLP-1R/GIPR AgonIST-1 is a double-receptor agonist for GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulin releasing peptide). GLP-1R/GIPR agonist-1 lowers blood sugar by mimicking the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while inhibiting glucagon secretion. GLP-1R/GIPR agonist-1 can be used in the study of metabolic diseases such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH).
GLP Receptor   Insulin Receptor  
Metabolic or Endocrine Disease  
/
HY-113066S2 Guanosine 5'-diphosphate-d13 dilithium
Guanosine 5'-diphosphate-d13 (GDP-d13) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
Isotope-Labeled Compounds   Endogenous Metabolite   Potassium Channel  
Inflammation or Immune System Disease  
/
HY-P3103A PINT-87aa TFA
PINT-87aa TFA, an 87-amino acid (aa) peptide, is encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT). PINT-87aa TFA directly interacts with polymerase associated factor complex (PAF1c) and inhibits the transcriptional elongation of multiple oncogenes. PINT-87aa TFA suppresses glioblastoma cell proliferation in vitro and in vivo.
DNA/RNA Synthesis  
/
HY-B1812S Veratrole-d4
Veratrole-d4 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-P3069 γ-Neuropeptide (rabbit)
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.
Neurokinin Receptor  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-B1812S1 Veratrole-d2
Veratrole-d2 is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Isotope-Labeled Compounds   Cytochrome P450  
/
HY-P991689 Girancitug
Girancitug is a humanized IgG1κ monoclonal antibody inhibitor targeting VEGFR2/KDR/CD309. Girancitug effectively inhibits angiogenesis. Girancitug can be used for anti-angiogenic therapy in cancers like colorectal and ovarian cancer research.

Species: Human

VEGFR  
Cancer  
/
HY-P11280A PRAME peptide (425-433) acetate
PRAME peptide (425-433) acetate is a proteasome-degraded peptide derived from the cancer-testis antigen PRAME (Preferentially Expressed Antigen in Melanoma). PRAME peptide (425-433) acetate is restricted by HLA-A*02:01 and can serve as a target for bispecific T cell engager therapy in the context of major histocompatibility complex I presentation. PRAME peptide (425-433) acetate shows application potential in various malignant tumors and is widely suitable for research related to solid tumors, melanoma, ovarian cancer, endometrial cancer, and lung cancer (including lung adenocarcinoma and lung squamous cell carcinoma). PRAME peptide (425-433) acetate can be used to explore disease of triple-negative breast cancer, diffuse large B-cell lymphoma, and head and neck squamous cell carcinoma.
Melanocortin Receptor  
Breast Cancer   Leukemia/Lymphoma/Myeloma   Ovarian Cancer   Lung Squamous Cell Carcinoma   Squamous Cell Carcinoma  
/
HY-148775 PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25)
PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) is a biodegradable amphipathic polymeric nanocarrier of poly (lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) modified with Angiopep-2 can cross the blood-brain barrier and exhibits targeting selectivity for glioblastoma cells. PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) can capture tumor-derived protein antigens, and exerts immunomodulatory effects when conjugated with anti-OX40 antibody; when used in combination with A2-CL/Dbait nanoparticles and radiotherapy, it prolongs survival time and reduces tumor volume in glioblastoma mouse models. PLGA-PEG-MAL (60kDa-3.4kDa, LA:GA ratio 75:25) can be used for studies related to bacterial wound infections and glioblastoma.
Biochemical Assay Reagents  
Bacterial Infection   Glioblastoma  
/
HY-P1558A ACTH (11-24) acetate
ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-15682G TTNPB (GMP)
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist.
RAR/RXR  
Cancer  
/
HY-P10358 TAT-CBD3A6K
TAT-CBD3A6K, is a modified TAT-CBD3 peptide. TAT-CBD3A6K reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. TAT-CBD3A6K shows anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy by preventing CRMP-2-mediated enhancement of T- and R-type calcium channel function.
Calcium Channel  
Neurological, Eye or Ear Disease  
/
HY-P10239 Tyr3-Octreotate
Tyr3-Octreotate is a ligand for somatostatin receptor subtype 2 (sst2), with an IC50 value of 1.3 nM against sst2 when labeled with [111In-DTPA], and an IC50 value of 1.6 nM against sst2 when labeled with [90Y-DOTA]. Radiolabeled Tyr3-Octreotate generates cell-associated radioactivity, and acts as both a tumor growth inhibitor and a tumor cytotoxic agent. When radiolabeled with 177Lu or 90Y, Tyr3-Octreotate serves as a peptide receptor radionuclide therapy (PRRT) analog. Tyr3-Octreotate can be used in studies related to pancreatic tumors.
Somatostatin Receptor   Radionuclide-Drug Conjugates (RDCs)  
Pancreatic Cancer  
/
HY-W744549 20β-Dihydrocortisol
20β-Dihydrocortisol (20β-DHF) is a metabolite of Hydrocortisone (Cortisol) (HY-N0583). 20β-Dihydrocortisol is a weak endogenous agonist of the glucocorticoid receptor (GR). 20β-Dihydrocortisol can be converted from Hydrocortisone via CBR1 catalysis, a process dependent on NADPH. 20β-Dihydrocortisol can be used for the study of obesity.
Glucocorticoid Receptor   Drug Metabolite  
Obesity  
/
HY-W759404 Clascoterone-d5
Clascoterone-d5 (Cortexolone 17 alpha-propionate-d5) is the deuterated analog of Clascoterone. Clascoterone is a topical and peripheral androgen antagonist.
Isotope-Labeled Compounds  
Metabolic or Endocrine Disease  
/
HY-128922S Dexamethasone palmitate-d31
Dexamethasone palmitate-d31 is the deuterium labeled Dexamethasone palmitate(HY-128922).Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation.
Isotope-Labeled Compounds   Sodium Channel  
Inflammation or Immune System Disease  
/
HY-113457S 11-Oxo etiocholanolone-d5
11-Oxo etiocholanolone-d5 (11-Ketoetiocholanolone-d5) is the deuterium labeled 11-Oxo etiocholanolone (HY-113457). 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a steroid. 11-Oxo etiocholanolone is a key indicator for detecting cortisol metabolites in feces and urine. 11-Oxo etiocholanolone has the potential to be a pheromone.
Isotope-Labeled Compounds   Endogenous Metabolite   Biochemical Assay Reagents  
Metabolic or Endocrine Disease  
/
HY-P990805 Anti-Human/Mouse GRP78 Antibody (C38)
Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b antibody inhibitor, targeting to GRP78. Anti-Human/Mouse GRP78 Antibody (C38) inhibits RhoA, ROCK and AKT activation. Anti-Human/Mouse GRP78 Antibody (C38) can be used for the researches of cancer and metabolic disease, such as melanoma and diabetes.

Species: Human/Mouse

HSP  
Cancer   Metabolic or Endocrine Disease  
/
HY-113066S Guanosine 5'-diphosphate-15N5 dilithium
Guanosine 5'-diphosphate-15N5 (GDP-15N5) dilithium is 15N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
Isotope-Labeled Compounds   Endogenous Metabolite   Potassium Channel  
Inflammation or Immune System Disease  
/
HY-180944 BE2012
BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels.
REV-ERB  
Muscle Disease  
/
HY-P99768 Olinvacimab
Olinvacimab (TTAC-0001) is a fully human anti-VEGFR2 monoclonal antibody. Olinvacimab inhibits VEGF binds to KDR with a Kd value of 0.23 nM. Olinvacimab has antiangiogenic activity. Olinvacimab can be used for the research of recurrent glioblastoma and breast cancer.

Species: Human

VEGFR  
Triple-Negative Breast Cancer  
/
HY-W014787S Decanedioic acid-d4
Decanedioic acid-d4 is the deuterium labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-112764GL mPEG2000-DMG (GMP Like)
mPEG2000-DMG (GMP Like) is mPEG2000-DMG (HY-112764) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
Liposome  
Metabolic or Endocrine Disease  
/
HY-P990295 Anti-Mouse CD103 Antibody (M290)
Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD103. Anti-Mouse CD103 Antibody (M290) can neutralize CD103. Anti-Mouse CD103 Antibody (M290) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as B16.gp33 tumor, colitis and diabetes.

Species: Mouse

Integrin  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-76025S 1,4-Dibromobenzene-d4
1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans.
Isotope-Labeled Compounds  
Inflammation or Immune System Disease  
/
HY-P5014 Cortistatin-29 (human)
Cortistatin-29 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain.
Somatostatin Receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-14648S5 Dexamethasone-d3-1
Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Mitophagy   Exosomes   Autophagy   ADC Payloads   Bacterial   Antibiotic   SARS-CoV   Complement System  
Cancer  
/
HY-N0583S3 Hydrocortisone-d3
Hydrocortisone-d3 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-113066S1 Guanosine 5'-diphosphate-13C10 dilithium
Guanosine 5'-diphosphate-13C10 (GDP-13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
Isotope-Labeled Compounds   Endogenous Metabolite   Potassium Channel  
Inflammation or Immune System Disease  
/
HY-P5003 Collagen Type II Fragment
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity.
MMP  
Inflammation or Immune System Disease  
/
HY-W250151 Leishman's stain
Leishman's stain is an essential staining tool for for staining of the peripheral blood and bone marrow smears (displayed pale bluish-grey to deep blue under oil-immersion lens).
Fluorescent Dye  
/
HY-N16579 (+)-Catechin 3-O-β-D-glucopyranoside
(+)-Catechin 3-O-β-D-glucopyranoside (Compound 13) is an anti-allergic agent found in Edulis Superba. (+)-Catechin 3-O-β-D-glucopyranoside can be used for the research of inflammation and immunology.
Others  
Inflammation or Immune System Disease  
/
HY-N9794 Isoboldine
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice.
Others  
Inflammation or Immune System Disease  
/
HY-77839S1 Cortodoxone-d2
Cortodoxone-d2 is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N9921 Antcin A
Antcin A is an orally active modulator of p53 and glucocorticoid receptor (GR), with an IC50 of 8.55 μM against human GR. Through transcriptional activation of p53, Antcin A induces miR-200c and inhibits ZEB1, regulates epithelial-mesenchymal transition markers, and suppresses cancer cell migration/invasion. Antcin A activates GR, inhibits Na+/K+-ATPase and NLRP3 inflammasome assembly, pyroptosis (pyroptosis) and pro-inflammatory cytokine release, reduces hepatic lipid deposition, improves liver function, and reverses metabolic changes induced by the SARS-CoV-2 spike protein. Antcin A can be used in research related to breast cancer, head and neck cancer, non-alcoholic fatty liver disease, and coronavirus disease 2019 (COVID-19).

Source: Antrodia cinnamomea

Pyroptosis   NOD-like Receptor (NLR)   MDM-2/p53   Glucocorticoid Receptor   MicroRNA   Na+/K+ ATPase   SARS-CoV  
Digestive System Disease   Breast Cancer   Coronavirus Infection   Digestive System Inflammation  
/
HY-P10289A Neuropeptide W-30 (rat) acetate
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses.
Neuropeptide B/W Receptor  
Neurological, Eye or Ear Disease  
/
HY-17447AG Tranylcypromine hydrochloride (GMP)
Tranylcypromine (SKF 385) hydrochloride (GMP) is Tranylcypromine hydrochloride (HY-17447A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine hydrochloride is a potent monoamine oxidase (MAO) inhibitor.
Monoamine Oxidase  
Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-D2188 IMP-2373
IMP-2373 is a low-toxicity activity-based probe targeting covalent pan-deubiquitinase (DUB), which modulates and monitors DUB activity via covalent binding to the catalytic cysteine and active site of DUB. IMP-2373 enables real-time tracking of dynamic intracellular DUB activity in physiologically relevant living cell systems, and quantitative analysis of activity changes induced by pharmacological inhibition or MYC dysregulation. IMP-2373 can be used for research on related diseases such as B-cell lymphoma.
Deubiquitinase  
Leukemia/Lymphoma/Myeloma  
/
HY-P991461 AMG-424
AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3.

Species: Human

CD38  
Cancer  
/
HY-P991470 Anti-Tenascin C Antibody
Anti-Tenascin C Antibody (Neuradiab antibody) is a human monoclonal antibody (mAb) targeting Tenascin C. Anti-Tenascin C Antibody can be used in Glioblastoma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Species: Human

Transmembrane Glycoprotein  
Cancer  
/
HY-P99702 Levilimab
Levilimab (BCD-089) is a fully humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody. Levilimab is an inflammation-alleviating antibody. Levilimab can be used for the research of rheumatoid.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-N0583S5 Hydrocortisone-d2
Hydrocortisone-d2 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-P99608 Exbivirumab
Exbivirumab is a monoclonal antibody directed against highly conserved HBsAg epitopes. Exbivirumab enhances the antiviral activity of hepatitis B immunoglobulin (HBIG). Exbivirumab combined with Libivirumab (HY-P99703) decreases circulating HBsAg and hepatitis B virus (HBV) DNA levels in a chronically infected chimpanzee. Exbivirumab can be used for HBV re-infection in liver transplant.

Species: Virus

HBV  
Infection  
/
HY-N3225 Myricanol
Myricanol is a diarylheptanoid and a Nampt activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through AMPK activation.
NAMPT   Sirtuin   Microtubule/Tubulin   Apoptosis   Autophagy   PDGFR   NF-κB   AMPK  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-P1245 Neuropeptide SF (human)
Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
CRFR  
/
HY-N9377 Platyconic acid A
Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation.
Others  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-N8167 Plantanone B
Plantanone B is a moderate antioxidant-agent with an IC50 of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research.
Free Radical Scavengers   COX  
Inflammation or Immune System Disease  
/
HY-P990801 Anti-Mouse CD11a/LFA-1α Antibody (M17/4)
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is an anti-mouse CD11a/LFA-1α IgG2a monoclonal antibody. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can reduce the recruitment of effector memory CD8 T cells. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) promotes the formation of xenograft tumors by reducing immune rejection reactions. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can be used for researches on cancer, infection conditions and immunology such as glioblastoma, parasitic and bacterial infections. The recommend isotype control of Anti-Mouse CD11a/LFA-1α Antibody (M17/4): Rat IgG2a kappa, Isotype Control (HY-P990679).

Species: Mouse

Integrin   Parasite   Bacterial  
Cancer   Infection   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-59320 4-Thiazolecarboxylic acid
4-Thiazolecarboxylic acid (Compound 1e) is an intermediate. 4-Thiazolecarboxylic acid can be used in the synthesis of MGL-IN-2 (HY-177534). MGL-IN-2 inhibits wild-type MGL enzyme activity with an IC50 of 0.0121 μM. 4-Thiazolecarboxylic acid can be used in the research of metabolic diseases.
Biochemical Assay Reagents   Drug Intermediate  
Metabolic or Endocrine Disease  
/
HY-P99948 Etevritamab
Etevritamab (AMG-596) is a bispecific T-cell engager that targets EGFRvIII and CD3. Etevritamab simultaneously binds CD3 on T cells and EGFRvIII on glioblastoma multiforme cells, thereby forming a bridge structure. Etevritamab triggers T-cell activation, proliferation, secretion of cytotoxic substances, and tumor cell lysis. Etevritamab extends overall survival and induces tumor regression in mouse models of glioblastoma multiforme. Etevritamab can be used for research related to glioblastoma.

Species: Human

EGFR   CD3  
Glioblastoma  
/
HY-D1299 meso-CF3-BODIPY 2
meso-CF3-BODIPY 2 (CF3-substituted Tetramethyl BODIPY) is a fluorescent dye with the absorption wavelength (λabs) of 553 nm and emission wavelength (λem) of 622 nm. meso-CF3-BODIPY 2 can be used in labeling reagents and photodynamic therapy.
Fluorescent Dye  
Cancer  
/
HY-N0583S1 Hydrocortisone-d7
Hydrocortisone-d7 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D2871 DAyne
DAyne is a Dopamine (DA)-mimetic probe. DAyne covalently binds to proteins modified by dopamine oxidation products (e.g., dopaquinone, DQ) to form adducts. DAyne is promising for research of Parkinson’s disease (PD), particularly neurotoxicity, protein modification, and related pathways (e.g., endoplasmic reticulum stress, cytoskeletal instability) caused by dopamine dysregulation.
Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-W587724S 6β-Hydroxy Cortisol-d4
6β-Hydroxy Cortisol-d4 is a deuterium labeled compound.
Isotope-Labeled Compounds  
/
HY-N8487 7-Methoxyflavone
7-Methoxyflavone is a flavonoid compound that can be isolated from Zornia brasiliensis. 7-Methoxyflavone can bind to human serum albumin and is an aromatase inhibitor. 7-Methoxyflavone has peripheral analgesic and certain antitumor activities. 7-Methoxyflavone is effective against chemical pain but has no significant effect on thermal pain.
Cytochrome P450  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-B1779S3 Sucrose-d14
Sucrose-d14 is the deuterium labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preferen
Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-P1582A ACTH (1-14) TFA
ACTH (1-14) (TFA) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.
Adrenergic Receptor  
/
HY-P11341 Kisspeptin antagonist p271
Kisspeptin antagonist p271 is a Kisspeptin antagonist with cell-penetrating ability. Kisspeptin antagonist p271 can block the binding of endogenous Kisspeptin to GPR54 on pituitary somatotropes, thereby relieving the inhibition of growth hormone secretion. Kisspeptin antagonist p271 can specifically and significantly stimulate growth hormone secretion, while inhibiting luteinizing hormone without affecting prolactin or cortisol. Kisspeptin antagonist p271 can be used in the research of diseases related to insufficient growth hormone secretion.
Kisspeptin Receptor  
Metabolic or Endocrine Disease  
/
HY-W011927R 4,4'-Sulfonyldiphenol (Standard)
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
Reference Standards   Estrogen Receptor/ERR   Histone Methyltransferase   Thyroid Hormone Receptor   PI3K   Akt   mTOR   Androgen Receptor   Drug Derivative  
Cancer   Inflammation or Immune System Disease   Blood or Cardio-cerebrovascular Disease   Metabolic or Endocrine Disease  
/
HY-W768340 Sucrose-13C6-1
Sucrose-13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
Isotope-Labeled Compounds  
Cancer   Metabolic or Endocrine Disease  
/
HY-76632 4-Hydroxyisophthalic acid
4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE, enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies.
Cholinesterase (ChE)   SOD  
Neurodegenerative Disease  
/
HY-P1558 ACTH (11-24)
ACTH (11-24) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
Melanocortin Receptor  
Neurological, Eye or Ear Disease  
/
HY-113215 Allotetrahydrocortisol
Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes.
Endogenous Metabolite  
/
HY-P5244 Tripeptide-32
Tripeptide-32 is a bioactive peptide that targets the PER1 gene. Tripeptide-32 can regulate circadian rhythms and stimulate the synthesis of cellular repair proteins, with anti-aging activity.
Others  
Metabolic or Endocrine Disease  
/
HY-W012734R L-Pipecolic acid (Standard)
L-Pipecolic acid (Standard) is an analytical standard of L-Pipecolic acid. This product is used for research and analytical applications. L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases.
Reference Standards   Endogenous Metabolite  
Metabolic or Endocrine Disease  
/
HY-113151 18-Oxocortisol
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.
Mineralocorticoid Receptor   Endogenous Metabolite  
Blood or Cardio-cerebrovascular Disease  
/
HY-B1812 Veratrole
Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii.
Cytochrome P450  
/
HY-B1779R Sucrose (Standard)
Sucrose (Standard) is the analytical standard of Sucrose. This product is intended for research and analytical applications. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al.
Reference Standards   Endogenous Metabolite  
Cancer   Metabolic or Endocrine Disease  
/
HY-P99223 Tovetumab
Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC).

Species: Human

PDGFR  
Respiratory Disease   Non-Small Cell Lung Cancer  
/
HY-P0060A Tetracosactide acetate
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
CRFR   Melanocortin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P10018 Bamadutide
Bamadutide (SAR425899) is a potent dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist. Bamadutide improves post-meal blood glucose control by significantly enhancing β-cell function and slowing down the rate of glucose absorption in the body. Bamadutide can be used for the research of metabolic diseases such as type 2 diabetes.
GLP Receptor   GCGR  
Metabolic or Endocrine Disease  
/
HY-17461R Cortisone (Standard)
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Reference Standards   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-W718300 Indole-3-pyruvic acid-d5
Indole-3-pyruvic acid-d5 is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety.
Isotope-Labeled Compounds  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P990260 Anti-Mouse CD86/B7-2 Antibody (GL-1)
Anti-Mouse CD86/B7-2 Antibody (GL-1) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD86/B7-2. Anti-Mouse CD86/B7-2 Antibody (GL-1) can be used for the researches of inflammation and immunology, such as allergic pulmonary inflammation.

Species: Mouse

Transmembrane Glycoprotein  
Inflammation or Immune System Disease  
/
HY-N6255 Ilexgenin A
Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer.
TNF Receptor  
Cancer   Autoimmune Disease  
/
HY-113418 Beta-Cortol
Beta-Cortol is an O-glycosylated compound and cortisol metabolite. It can be isolated from the leaves of mulberry cultivar Yu 711, and its concentration decreases significantly when the plant is subjected to drought stress. Beta-Cortol serves as a biomarker, as serum Beta-Cortol levels in early non-small cell lung cancer models are downregulated to 1/8 of the preoperative level after tumor resection. Due to such dramatic changes under specific pathological conditions, Beta-Cortol is currently widely used in studies related to early non-small cell lung cancer.
Endogenous Metabolite  
Non-Small Cell Lung Cancer  
/
HY-P99292 Fontolizumab
Fontolizumab (HuZAF) is a human monoclonal antibody targeting interferon γ (IFN-γ). Fontolizumab binds specifically and with high affinity to secreted IFN-γ, neutralizes its activity, blocks receptor binding, and inhibits downstream signal transduction and the expression of IFNγ-responsive genes. Fontolizumab reduces serum C-reactive protein levels, inhibits the expression of IL-1α, IL-1β and IL-12Rβ2, and decreases the number of IFNγ-producing T cells in activated peripheral blood mononuclear cells. Fontolizumab can be used in research related to Crohn's disease.

Species: Human

IFNAR  
Digestive System Disease   Digestive System Inflammation   Crohn's Disease  
/
HY-W768338 Sucrose-13C
Sucrose-13C is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.
Isotope-Labeled Compounds  
Cancer   Metabolic or Endocrine Disease  
/
HY-113422 Tetrahydrocorticosterone
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
Endogenous Metabolite   Glucocorticoid Receptor  
Inflammation or Immune System Disease  
/
HY-17461S1 Cortisone-d8
Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
Isotope-Labeled Compounds   Glucocorticoid Receptor   Endogenous Metabolite  
Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-101018 Propionyl-DL-carnitine chloride
Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation.
Endogenous Metabolite  
Inflammation or Immune System Disease  
/
HY-117516 SR10067
SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders.
REV-ERB  
Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-P5011 Cortistatin-17 (human)
Cortistatin-17 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain.
Somatostatin Receptor  
Cancer   Inflammation or Immune System Disease  
/
HY-129440 N-(p-Coumaroyl) Serotonin
N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure.
NF-κB   Toll-like Receptor (TLR)   p38 MAPK   NO Synthase   COX   ERK   Caspase   PDGFR   MyD88   Reactive Oxygen Species (ROS)   Apoptosis  
Neurodegenerative Disease   Glioblastoma   Atherosclerosis and Inflammation   Renal Failure  
/
HY-125911 Gossypin
Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study.
NF-κB   Aurora Kinase   Ribosomal S6 Kinase (RSK)   Apoptosis   Caspase   Bcl-2 Family   PARP   Cryptochrome  
Breast Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease   Glucose Metabolism   Obesity  
/
HY-112624F CY7-Dextran (MW 4000)
CY7-Dextran (MW 4000) is a fluorescent dye that consists of CY7 (HY-D0825) and Dextran (HY-112624) (Ex=740 nm; Em=770 nm). CY7-Dextran (MW 4000) can be used as a cell volume indicator and delineates the thin peripheral edges of the cells.
Fluorescent Dye  
/
HY-P99943 Erfonrilimab
Erfonrilimab (KN-046) is a monoclonal antibody targeting PD-L1/CTLA-4. Erfonrilimab blocks the PD-L1 and CTLA-4 pathways, thereby regulating T cell function. Erfonrilimab enhances the secretion of IL-2 in superantigen-stimulated peripheral blood mononuclear cells. Erfonrilimab inhibits tumor growth in xenograft and double gene knock-in mouse models. Erfonrilimab can be used in research related to a variety of advanced solid tumors, including non-small cell lung cancer and nasopharyngeal carcinoma.

Species: Human

PD-1/PD-L1   CTLA-4  
Non-Small Cell Lung Cancer   Nasopharyngeal Cancer  
/
HY-148103 SR12418
SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research.
REV-ERB  
Inflammation or Immune System Disease  
/
HY-P2479 Peripheral Myelin Protein P2 (53-78), bovine
Peripheral Myelin Protein P2 (53-78), bovine is derived from bovine peripheral myelin P2 protein amino acid residues 53-78. Peripheral Myelin Protein P2 (53-78), bovine is a T cell epitope for the induction of experimental autoimmune neuritis (EAN) in Lewis rats.
Others  
Inflammation or Immune System Disease  
/
HY-15001G Stemregenin 1 (GMP)
Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC50 of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases.
Aryl Hydrocarbon Receptor  
Cancer  
/
HY-N3995 5β-Dihydrocortisol
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.
Apoptosis   Drug Metabolite  
Digestive System Disease   Breast Cancer   Digestive System Inflammation  
/
HY-162160 NR12S
NR12S is a fluorescent probe that specifically binds to the outer leaflet of membranes. NR12S exhibits phase-sensitive red edge excitation shift, emission wavelength shift and lifetime changes, which depend on membrane phase, cholesterol content and lipid acyl chain properties. NR12S can be used to study cholesterol and lipid order in biological membranes.
Fluorescent Dye  
/
HY-NP009 α-Lactalbumin
α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca2+, Mg2+, Mn2+, Na+, K+ and Zn2+ ions; among these, Ca2+ binding enhances protein stability, while Zn2+ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions.
Bacterial  
Infection   Depression   Anxiety or Fear-Related Disease  
/
HY-116583 Resorufin butyrate
Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm).
Cholinesterase (ChE)  
Metabolic or Endocrine Disease  
/
HY-W250120 Konjac glucomannan (Viscosity≥15000mPa.s)
Konjac glucomannan (Viscosity≥15000mPa.s) is an orally active acetylated (1-4)-β-D-glucomannan with multiple biological activities including anti-diabetic, anti-obesity, anti-inflammatory effects, as well as film-forming and gelling properties. Konjac glucomannan (Viscosity≥15000mPa.s) forms a defensive coating on the intestinal surface, reducing levels of blood glucose, cholesterol, triglycerides and blood pressure; it is specifically degraded by colonic β-mannanase produced by human colonic bacteria. Konjac glucomannan (Viscosity≥15000mPa.s) can be used as a food additive, dietary supplement and excipient for oral colon-targeted drug delivery systems. Konjac glucomannan (Viscosity≥15000mPa.s) is applicable to research related to various diseases such as type 2 diabetes, obesity, atopic dermatitis and metabolic syndrome, as well as research in fields including biotechnology, pharmaceuticals and tissue engineering.
Biochemical Assay Reagents   Drug Intermediate  
Atopic Dermatitis   Type 2 Diabetes   Obesity  
/
HY-P11099 Cys-LT7
Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma.
Transferrin Receptor  
Lung Cancer   Liver Cancer   Glioblastoma  
/
HY-N10610 Ethyl rosmarinate
Ethyl rosmarinate is a phenolic compound that can be isolated from Lycopus lucidus. Ethyl rosmarinate has antioxidative activity. Ethyl rosmarinate inhibits lung inflammation.
Others  
Inflammation or Immune System Disease  
/
HY-P10473A CPN-351 TFA
CPN-351 TFA (compound 9a), a pentapeptide, is a selective antagonist of human NMUR1 with a pA2 of 7.35. The antagonistic effect of CPN-351 TFA on human NMUR1 is 10 times higher than that on NMUR2. CPN-351 TFA can be used in the study of inflammation. X
Neuromedin U Receptor (NMUR)  
Inflammation or Immune System Disease  
/
HY-P99266 Zanolimumab
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody targets CD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma.

Species: Human

Transmembrane Glycoprotein  
Cancer   Inflammation or Immune System Disease  
/
HY-119575 Tetramethyluric acid
Tetramethyluric acid (1,3,7,9-Tetramethyluric acid) is an orally active purine alkaloid in Coffea species and Camellia kucha. Tetramethyluric acid exhibits antiviral, and anti-inflammatory activity. Tetramethyluric acid can be used for the research of inflammation disease, and influenza virus infection.
Influenza Virus   Collagen   Sirtuin   Interleukin Related   TGF-beta/Smad   ERK   p38 MAPK  
Inflammation or Immune System Disease  
/
HY-N0610AS Cinnamic acid-d6
Cinnamic acid-d6 is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
Endogenous Metabolite  
/
HY-W010162 H-Ala-Ala-OH
H-Ala-Ala-OH is a substrate of human intestinal oligopeptide transporter (PEPT1/SLC15A1), with an IC50 of 0.25 mM and an EC50 of 0.08 mM against human PEPT1. When used as a dipeptide linker in antibody-drug conjugates (ADCs) loaded with glucocorticoid receptor regulator payloads, H-Ala-Ala-OH enables efficient intracellular payload release.
Amino Acid Derivatives  
/
HY-N3266 Methyl rosmarinate
Methyl rosmarinate is an orally active hydroxycinnamic acid. Methyl rosmarinate exhibits an IC50 of 24.70 μM and a Ki of 15.29 μM against PTP1B, an IC50 of 41.46 μg/mL against BChE, a Ki of 0.61 mM against mushroom tyrosinase, and an IC50 of 2.50 μM against SARS-CoV-2 3CLpro. Methyl rosmarinate downregulates the phosphorylation levels of ERK, JNK, p38, Smad2 and Smad3. Methyl rosmarinate activates erythrocyte BPGM and promotes the production of 2,3-BPG. Methyl rosmarinate induces apoptosis of fibroblasts. Methyl rosmarinate prolongs the survival time of hypoxic mice. Methyl rosmarinate improves insulin sensitivity. Methyl rosmarinate binds to SARS-CoV-2 3CLpro and inhibits viral replication. Methyl rosmarinate induces glioblastoma cell death. Methyl rosmarinate activates the TGR5/AMPK axis and reduces the levels of ROS and MDA. Methyl rosmarinate shows inhibitory activity against MMP-1. Methyl rosmarinate can be used in research related to pulmonary fibrosis, hypoxia-induced injury, type 2 diabetes, Alzheimer's disease, hyperpigmentation disorders, COVID-19, glioblastoma and myocardial ischemia-reperfusion injury.
Tyrosinase   Phosphatase   Cholinesterase (ChE)   SARS-CoV   PERK   JNK   p38 MAPK   TGF-beta/Smad   Apoptosis   Reactive Oxygen Species (ROS)   AMPK   MMP  
Cancer   Blood or Cardio-cerebrovascular Disease   Autoimmune Disease   SARS-CoV-2 Infection   Alzheimer's Disease   Lung Fibrosis  
/
HY-W583212 Zn(II) Mesoporphyrin IX
Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention.
Biochemical Assay Reagents   Heme Oxygenase (HO)  
Inflammation or Immune System Disease  
/
HY-P99246 Bermekimab
Bermekimab (MABp1) is a human monoclonal antibody targeting interleukin-1α(IL-1α) . Bermekimab can prevent tumor-related inflammation. Bermekimab can be used in the research of atopic dermatitis.

Species: Human

Interleukin Related  
Cancer   Inflammation or Immune System Disease  
/
HY-114118CP Semaglutide (crude)
Semaglutide (crude) is the crude form of Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances Autophagy, inhibits oxidative stress and Apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.
GLP Receptor   Insulin Receptor   α-synuclein   Apoptosis   p38 MAPK   Autophagy   Bcl-2 Family  
Cancer   Neurological, Eye or Ear Disease   Metabolic or Endocrine Disease  
/
HY-13257G Thiazovivin (GMP)
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor.
ROCK  
Cancer  
/
HY-W009154 3,6-Dibromocarbazole
3,6-Dibromocarbazole is a glucocorticoid receptor (GR) inhibitor and Environmental pollutant. 3,6-Dibromocarbazole induces abnormal development of zebrafish embryos and disrupts the neurohormonal function of the hypothalamic-pituitary-adrenal axis in zebrafish larvae. 3,6-Dibromocarbazole increases the α-diversity of soil bacteria, alters community structure, enhances interspecific competition, regulates metabolic functions, and changes the abundance of genes related to nitrogen fixation, nitrification and carbon cycling. 3,6-Dibromocarbazole exerts endocrine-disrupting potential by interfering with the gluconeogenesis pathway.
Environmental Pollutants   Glucocorticoid Receptor   Bacterial  
Metabolic or Endocrine Disease   Bacterial Infection  
/
HY-P0060 Tetracosactide
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
CRFR   Melanocortin Receptor  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-13027G DAPT (GMP)
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor.
γ-secretase  
Cancer   Neurological, Eye or Ear Disease   Inflammation or Immune System Disease  
/
HY-P99806 Pritumumab
Pritumumab is a natural human IgG1kappa mAb originally isolated from a regional draining lymph node of a patient with cervical carcinoma. Pritumumab recognizes vimentin expressing on the cell surface of the malignant tumor. Pritumumab can be used for glioblastoma research.

Species: Human

Others  
Cancer  
/
HY-129630 Tetrahydrocortisol
Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer.
Drug Metabolite   Glucocorticoid Receptor  
Lung Cancer   Breast Cancer   Ocular Hypertension  
/
HY-W073080 Coproporphyrin I dihydrochloride
Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research.
MOFs  
/
HY-108786 Asfotase alfa
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 / knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP).

Species: Human

Phosphatase  
Metabolic or Endocrine Disease  
/
HY-113114 Tetrahydrocortisone
Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status.
Endogenous Metabolite   Glucocorticoid Receptor  
Digestive System Disease   Digestive System Inflammation   Type 2 Diabetes  
/
HY-D0168 Orcinol
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases.

Source: Aspergillus niger

Fluorescent Dye   Free Radical Scavengers   Tyrosinase   p38 MAPK   ERK  
Cancer   Metabolic or Endocrine Disease  
/
HY-Y1673 Potassium bromide, 99%
Potassium bromide, 99% is a salt, widely used as an anticonvulsant and a sedative. Potassium bromide is a redox reagent that can be used to remove peripheral membrane proteins in molecular biology.
Environmental Pollutants   Biochemical Assay Reagents  
Neurological, Eye or Ear Disease  
/
HY-P990213 Anti-Mouse/Human IL-5 Antibody (TRFK5)
Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived anti-mouse IL-5 IgG1 κ type antibody inhibitor. Anti-Mouse/Human IL-5 Antibody (TRFK5) can significantly decrease eosinophils. Anti-Mouse/Human IL-5 Antibody (TRFK5) shows potent anti- inflammation effect on pulmonary inflammation and asthma.

Species: Human/Mouse

Interleukin Related  
Inflammation or Immune System Disease   Lower Respiratory Inflammation  
/
HY-ER013C Sodium carbonate anhydrous, 99.8%
Sodium carbonate, SP is a biochemical reagent and a buffer component that can be used to remove peripheral membrane proteins.
Environmental Pollutants   Biochemical Assay Reagents  
/
HY-P1160 Bay 55-9837
Bay 55-9837 is a potent and highly selective agonist of VPAC2, with a Kd of 0.65 nM. Bay 55-9837 may be a useful therapy for the research of type 2 diabetes.
GCGR  
Metabolic or Endocrine Disease  
/
HY-P991504 LAE-102
LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity.

Species: Human

Anaplastic lymphoma kinase (ALK)   TGF-β Receptor   TGF-beta/Smad  
Obesity  
/
HY-129109 NBD-Pen
NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λex: 470 nm, λem: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H2O2, ClO-, O2-?, and ?OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma.
Fluorescent Dye  
Cancer   Inflammation or Immune System Disease  
/
HY-N0583S2 Hydrocortisone-d4
Hydrocortisone-d4 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
Glucocorticoid Receptor   Endogenous Metabolite  
Cancer   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
/
HY-D1122 Janus green B
Janus green B is a supravital stain. Janus green B staining reaction is oxygen dependent, and is reversibly inhibited by cyanide. Janus Green B has been used to stain structures such as peripheral nerves in living insects, rabbit lymphatic vessels, mitochondria, and mast cells.
Fluorescent Dye  
/
HY-P99908 Efineptakin alfa
Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4+ and CD8+ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research.
Interleukin Related  
Cancer  
/
HY-19204 Zinc phthalocyanine
Zinc phthalocyanine (ZnPc) is commonly applied in industry (catalysts, photoconductors) and biomedical (photodynamic therapy, PDT). Zinc phthalocyanine can be used to photooxidise cyclohexane and is promising for research of solar-cell applications.
Ligands for Target Protein for PROTAC   Reactive Oxygen Species (ROS)   Apoptosis   Caspase  
Cancer  
/
HY-150097 Recombinant Human Serum Albumin(rHSA)
Recombinant Human Serum Albumin (rHSA) is a non-glycosylated monomeric plasma protein that acts as a core factor for maintaining plasma colloid osmotic pressure. Recombinant Human Serum Albumin (rHSA) possesses multiple physiological functions including carrier, metabolic regulation, detoxification, antioxidation and enzyme mimicking. Recombinant Human Serum Albumin (rHSA) not only scavenges reactive oxygen and nitrogen species via specific residues and binds a variety of endogenous and exogenous compounds to maintain redox homeostasis, but also serves as a biomarker for multiple diseases such as cancer and inflammation. Recombinant Human Serum Albumin (rHSA) broadly supports the development of implantable materials, surgical adhesives and ligand capture, and can be used for research on critical illnesses including hypovolemia, liver failure, severe sepsis and various types of trauma resuscitation.
Biochemical Assay Reagents  
Cancer   Inflammation or Immune System Disease   Liver Failure  
/
HY-P3160C Fibronectin, bovine plasma
Fibronectin, bovine plasma is a fibronectin derived from bovine plasma. Fibronectin is an extracellular matrix protein that is upregulated and essential in many developmental processes, and also exists in the pathological progression of tissues and wound healing. Fibronectin specifically binds to a large number of molecules, including other components of the extracellular matrix, signaling molecules and cell adhesion molecules. The interaction between cells and fibronectin leads to bidirectional crosstalk, which regulates cell functions and induces cell-dependent changes in the extracellular matrix. Fibronectin, bovine plasma inhibits the production of bovine leukemia virus (BLV) p24 core protein in naturally infected bovine peripheral blood mononuclear cells.
Biochemical Assay Reagents  
Viral Infection  
/
HY-B1203 Fludrocortisone
Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
Mineralocorticoid Receptor   Glucocorticoid Receptor   Apoptosis  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Metabolic or Endocrine Disease   Small Cell Lung Cancer  
/
HY-P990125 Anti-Mouse CSF1R/CD115 Antibody (AFS98)
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis.

Species: Mouse

c-Fms  
Neurological, Eye or Ear Disease   Inflammation or Immune System Disease   Arthritis   Atherosclerosis   Type 2 Diabetes  
/
HY-132809 Baxdrostat
Baxdrostat is a aldosterone synthase inhibitor.
Mineralocorticoid Receptor  
Metabolic or Endocrine Disease  
/
HY-Y0651 Sodium sulfite
Sodium sulfite is an inorganic salt used as an antioxidant and preservative. Sodium sulfite is also used in sulfonation and sulfomethylation reactions. Sodium sulfite can also be used as a bleaching agent, desulfurizer, and dechlorinator. Sodium sulfite inhibits hepatocyte proliferation, promotes hepatocyte apoptosis and necrosis, and impairs mitochondrial integrity. Sodium sulfite induces superoxide anion production, primes neutrophils for enhanced superoxide anion generation, and induces neutrophil gene expression. Sodium sulfite can be used in studies related to pulmonary inflammation and gastric tissue injury.
Free Radical Scavengers   Biochemical Assay Reagents  
Infection   Antioxidant Agent  
/
HY-W011927 4,4'-Sulfonyldiphenol
4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
Estrogen Receptor/ERR   Histone Methyltransferase   Thyroid Hormone Receptor   PI3K   Akt   mTOR   Androgen Receptor   Drug Derivative  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Cardiovascular Disease  
/
HY-P11274A Zenagamtide sodium
Zenagamtide (Amycretin; NN 9487) sodium is an orally active, blood-brain barrier permeable triple agonist that targets GLP-1, amylin (Amylin Receptor) and calcitonin receptor (Calcitonin Receptor). Zenagamtide sodium is a single peptide consisting of 68 amino acids that can target brain regions regulating food intake, significantly suppress appetite and reduce energy intake. Therefore, Zenagamtide sodium improves body weight, waist circumference, glycated hemoglobin and lipid profile, and also alleviates the histological features of metabolic dysfunction-associated steatotic liver disease (MASLD) and enhances insulin sensitivity. Zenagamtide sodium may cause transient increases in heart rate and fluctuations in serum calcium levels, but it is an important compound for the study of overweight, obesity, insulin resistance and related metabolic diseases.
Amylin Receptor   Insulin Receptor   GCGR  
Metabolic or Endocrine Disease  
/
HY-W087830 L-p-Boronophenylalanine
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma.
Biochemical Assay Reagents  
Cancer  
/
HY-P99111 Golimumab
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.

Species: Human

TNF Receptor   Apoptosis   Interleukin Related   Caspase  
Cancer   Rheumatoid Arthritis  
/
HY-P4153 Enlicitide chloride
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC50 of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders.
PCSK9  
Blood or Cardio-cerebrovascular Disease  
/
HY-P990798 Anti-Mouse IFN gamma Antibody (XMG1.2)
Anti-Mouse IFN gamma Antibody (XMG1.2) is a kind of rat-derived IgG1 antibody inhibitor, targeting to IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can neutralize IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can be used for the researches of cancer, inflammation and immunology, such as multiple myeloma and chronic inflammation.

Species: Mouse

IFNAR  
Inflammation or Immune System Disease   Multiple Myeloma  
/
HY-109017 Vamorolone
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
Glucocorticoid Receptor   Mineralocorticoid Receptor   NF-κB  
Breast Cancer   Prostate Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Depression   Pain   Digestive System Inflammation   Obesity  
/
HY-P71628 FOXP3 Protein, Human (His)
FOXP3 is a key transcriptional regulator essential for the development and function of regulatory T cells (Tregs), ensuring immune system homeostasis. It acts as a dual repressor and activator, regulating Treg suppressive function and stability while affecting conventional T cell expansion. FOXP3 Protein, Human (His) is the recombinant human-derived FOXP3 protein, expressed by E. coli , with N-His labeled tag.

Species: Human; Source: E. coli

/
HY-P73929 HER2/CD340 Protein, Mouse (HEK293, His)
The HER2/CD340 protein is a multifunctional tyrosine kinase that is a component of the neuregulin receptor complex and regulates microtubule dynamics. Activated HER2/CD340 triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B on the cell membrane and promotes the binding of APC and CLASP2, which is critical for microtubule stability. HER2/CD340 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HER2/CD340 protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

/
HY-P75931 Myocilin Protein, Human (HEK293, His)
Myofin is a secreted glycoprotein that regulates diverse cellular processes such as adhesion, cytoskeletal organization, and migration. It promotes matrix adhesion, spreading, and focal contact formation while negatively affecting cell-matrix adhesion and stress fiber assembly through Rho protein signaling. Myocilin Protein, Human (HEK293, His) is the recombinant human-derived Myocilin protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

/
HY-P75369 CD97 Protein, Human (HEK293, His)
CD97, a receptor crucial for leukocyte migration, participates in adhesion and signaling during early leukocyte activation. Forming a heterodimer with a large extracellular alpha subunit and a seven-transmembrane beta subunit, CD97 interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) specifically engages with chondroitin sulfate, showcasing its diverse roles in cellular processes. CD97 Protein, Human (HEK293, His) is the recombinant human-derived CD97 protein, expressed by HEK293 , with C-His labeled tag.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Cell Adhesion-related CD Proteins G-Protein-Coupled Receptors (GPCRs) Adhesion GPCRs CD97

/
HY-P702781 NR3C1 Protein, Human (His)
NR3C1 Protein, Human (His) is the recombinant human-derived NR3C1, expressed by E. coli , with C-6*His labeled tag.

Species: Human; Source: E. coli

/
HY-P78448 AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag)
AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) is a recombinant human AITRL (Q72-S199) trimer with N-terminal His and Flag tag, which is expressed in HEK293.

Species: Human; Source: HEK293

Cytokines and Growth Factors TNF Superfamily TNF Superfamily Ligands GITRL/AITRL

/
HY-P70759 HER2/CD340 Protein, Human (HEK293, Fc)
HER2/CD340 Protein, Human (HEK293, Fc) is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (HEK293, Fc) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

/
HY-P702478 TSPO Protein, Mouse (Cell-Free, His)
The TSPO protein was originally thought to be a peripheral benzodiazepine receptor that binds protoporphyrin IX and isoquinoline carboxamide. TSPO Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived TSPO protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

Species: Mouse; Source: E. coli Cell-free

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HY-P75805 HER2/CD340 Protein, Cynomolgus (HEK293, His)
Erb-b2 receptor tyrosine kinase 2 is a member of EGFR family. Erb-b2 receptor tyrosine kinase 2 is over-expressed in the tumors of many types of cancers. Erb-b2 receptor tyrosine kinase 2 enables ATP binding and transmembrane receptor protein tyrosine kinase activity. HER2/CD340 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived HER2/CD340 protein, expressed by HEK293 , with C-His labeled tag.

Species: Cynomolgus; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P74895 HER2/CD340 Protein, Rat (HEK293, His)
The HER2/CD340 protein is a multifunctional tyrosine kinase that is a component of the neuregulin receptor complex and regulates microtubule dynamics.Activated HER2/CD340 triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B on the cell membrane and promotes the binding of APC and CLASP2, which is critical for microtubule stability.HER2/CD340 Protein, Rat (HEK293, His) is the recombinant rat-derived HER2/CD340 protein, expressed by HEK293 , with C-10*His labeled tag.

Species: Rat; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P75164 GITR Protein, Mouse (HEK293, His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Mouse (HEK293, His) is a recombinant protein with a C-terminal His label and is produced in HEK293 cells.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P75370 CD97 Protein, Human (HEK293, hFc)
CD97, a receptor crucial for leukocyte migration, participates in adhesion and signaling during early leukocyte activation. Forming a heterodimer with a large extracellular alpha subunit and a seven-transmembrane beta subunit, CD97 interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) specifically engages with chondroitin sulfate, showcasing its diverse roles in cellular processes. CD97 Protein, Human (HEK293, hFc) is the recombinant human-derived CD97 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Human; Source: HEK293

CD Antigens Receptor Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Cell Adhesion-related CD Proteins G-Protein-Coupled Receptors (GPCRs) Adhesion GPCRs CD97

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HY-P73097 HER2/CD340 Protein, Rat (HEK293)
The HER2/CD340 Protein is a member of the receptor tyrosine kinase family.HER2/CD340 Protein participates in the PI3K/Akt signaling pathway to regulate the differentiation and apoptosis of neural stem cells in the cochlear nucleus.HER2/CD340 Protein is an overexpressed oncogenic factor in bladder cancer that activates the oncogenic signaling pathway, thereby promoting tumor cell survival/proliferation.HER2/CD340 Protein, Rat (HEK293) is the recombinant rat-derived HER2/CD340 protein, expressed by HEK293 , with tag free.

Species: Rat; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P701783 SGK Protein, Human (Inactive, sf9)
SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK Protein, Human (sf9) is the recombinant human-derived SGK protein, expressed by sf9 insect cells , with tag free.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC SGK SGK1/SGK

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HY-P703462 VSD4-NaV1.7-NaVPas Protein, Human (HEK293, Flag, Strep)
VSD4-NaV1.7-NaVPas Protein, Human (HEK293, Flag, Strep) is the recombinant human-derived VSD4-NaV1.7-NaVPas, expressed by HEK293 , with Strep, Flag labeled tag.

Species: Human; Source: HEK293

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HY-P704620 FOXP3 Protein, Human (431a.a, His)
FOXP3 is a key transcriptional regulator essential for the development and function of regulatory T cells (Tregs), ensuring immune system homeostasis. It acts as a dual repressor and activator, regulating Treg suppressive function and stability while affecting conventional T cell expansion. FOXP3 Protein, Human (431a.a, His) is the recombinant human-derived FOXP3 protein, expressed by E. coli, with N-His labeled tag.

Species: Human; Source: E. coli

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HY-P7S0151 CRY1 Protein, Human (His, Myc)
CRY1 Protein, Human (His, Myc) is the recombinant human-derived CRY1, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of CRY1 Protein, Human (His, Myc) is 586 a.a.,

Species: Human; Source: E. coli

Receptor Proteins

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HY-P73076 GITR Protein, Human (HEK293, His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, His) is a recombinant protein with a C-terminal His label, It consists of 161 amino acids (M1-E161) and is produced in HEK293 cells.

Species: Human; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P70328 Myelin protein P0/MPZ Protein, Human (HEK293, His)
Myelin protein P0 (MPZ) is a crucial adhesion molecule essential for normal myelination in the peripheral nervous system. Acting as an adhesion mediator between adjacent myelin wraps, MPZ plays a pivotal role in myelin compaction. Its homodimeric and homotetrameric structures underscore its significance in establishing necessary cellular interactions for myelin formation and integrity in the peripheral nervous system. Myelin protein P0/MPZ Protein, Human (HEK293, His) is the recombinant human-derived Myelin protein P0/MPZ protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Human; Source: HEK293

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HY-P70683 GITR Protein, Human (HEK293, hFc)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (HEK293, hFc) is a recombinant protein with a C-terminal Fc label, It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

Species: Human; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P71066 PMP2 Protein, Human (His)
The PMP2 protein may act as a lipid transporter within Schwann cells, suggesting a role in lipid transport and cellular homeostasis. PMP2 may also bind cholesterol, suggesting involvement in cholesterol-related pathways. PMP2 Protein, Human (His) is the recombinant human-derived PMP2 protein, expressed by E. coli , with N-6*His labeled tag.

Species: Human; Source: E. coli

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HY-P74349 CASK Protein, Human (sf9)
CASK protein is a Mg(2+)-independent multidomain scaffold kinase that catalyzes phosphate transfer to proteins, including NRXN1, thereby contributing to synaptic transmembrane protein anchoring and ion channel trafficking. It plays a critical role in neural development, regulation of gene expression through TBR1 interactions, and mediates connections between the extracellular matrix, multiligands, and the actin cytoskeleton. CASK Protein, Human (sf9) is the recombinant human-derived CASK protein, expressed by Sf9 insect cells , with tag free.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CASK

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HY-P74897 HER2/CD340 Protein, Canine (HEK293, His)
The HER2/CD340 Protein is a member of the receptor tyrosine kinase family. HER2/CD340 Protein participates in the PI3K/Akt signaling pathway to regulate the differentiation and apoptosis of neural stem cells in the cochlear nucleus. HER2/CD340 Protein is an overexpressed oncogenic factor in bladder cancer that activates the oncogenic signaling pathway, thereby promoting tumor cell survival/proliferation. HER2/CD340 Protein, Canine (HEK293, His) is the recombinant canine-derived HER2/CD340 protein, expressed by HEK293 , with C-His labeled tag.

Species: Canine; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P78640 GITR Protein, Canine (HEK293, His)
GITR is a type I transmembrane protein. GITR mediates signal transduction through NF-kB and MAPK pathways. Protects T cells from cell death induced by TCR activation. GITR inhibits proliferation and induces apoptosis of Multiple Myeloma (MM) cells in vitro and in vivo. GITR Protein, Canine (HEK293, His) is the recombinant canine-derived GITR protein, expressed by HEK293 , with C-6*His labeled tag.

Species: Canine; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P72626 HER2/CD340 Protein, Rat (His)
The HER2/CD340 protein is a key protein tyrosine kinase that is a component of multiple cell surface receptor complexes and requires coreceptors for ligand binding.Its interaction within the neuregulin-receptor complex depends on neuregulin, and GP30 emerges as a potential ligand.HER2/CD340 Protein, Rat (His) is the recombinant rat-derived HER2/CD340 protein, expressed by E.coli , with C-6*His labeled tag.

Species: Rat; Source: E. coli

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P72631 GITR Protein, Mouse (HEK293, Fc-His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Mouse (HEK293, Fc-His) is a recombinant protein with a C-terminal Fc label and a C-terminal His label, It consists of 132 amino acids (S22-H153) and is produced in HEK293 cells.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P73930 HER2/CD340 Protein, Mouse (HEK293, Fc)
The HER2/CD340 protein is a multifunctional tyrosine kinase that is a component of the neuregulin receptor complex and regulates microtubule dynamics. Activated HER2/CD340 triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B on the cell membrane and promotes the binding of APC and CLASP2, which is critical for microtubule stability. HER2/CD340 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived HER2/CD340 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P75163 GITR Protein, Rat (HEK293, Fc)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Rat (HEK293, Fc) is a recombinant protein with a C-terminal Fc label, It consists of 121 amino acids (M1-K121) and is produced in HEK293 cells.

Species: Rat; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P75165 GITR Protein, Mouse (HEK293, Fc)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Mouse (HEK293, Fc) is a recombinant protein with a C-terminal Fc label and is produced in HEK293 cells.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P76063 SGK3 Protein, Human (Active, sf9, GST)
The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (sf9, GST) is the recombinant human-derived SGK3 protein, expressed by Sf9 insect cells , with GST tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC Cytokine-independent Survival Kinase (SGK3) SGK

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HY-P76362 GITR Protein, Cynomolgus (HEK293, His)
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Cynomolgus (HEK293, His) is a recombinant protein with a C-terminal His label, It consists of 155 amino acids (M1-E155) and is produced in HEK293 cells.

Species: Cynomolgus; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P78716 GITR Protein, Cynomolgus (HEK293, Fc)
GITR Protein, Cynomolgus (HEK293, Fc) is the recombinant Rhesus Macaque-derived GITR protein, expressed by HEK293, with C-hFc labeled tag.

Species: Rhesus Macaque; Source: HEK293

Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens Receptor Proteins TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Cytokine Receptors TNF Receptor Superfamily GITR/CD357

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HY-P74896 HER2/CD340 Protein, Rat (HEK293, Fc)
The HER2/CD340 protein is a multifunctional tyrosine kinase that is a component of the neuregulin receptor complex and regulates microtubule dynamics.Activated HER2/CD340 triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B on the cell membrane and promotes the binding of APC and CLASP2, which is critical for microtubule stability.HER2/CD340 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER2/CD340 protein, expressed by HEK293 , with C-hFc labeled tag.

Species: Rat; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P701784 SGK Protein, Human (sf9, His, GST)
SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK Protein, Human (sf9, His, GST) is the recombinant human-derived SGK protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC SGK SGK1/SGK

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HY-P703275 KCC3 Protein, Human (HEK293, His, MBP, Flag)
KCC3 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived KCC3, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

Species: Human; Source: HEK293

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HY-P703276 KCC3 Protein, Human (HEK293)
KCC3 Protein, Human (HEK293) is the recombinant human-derived KCC3, expressed by HEK293 , with tag Free labeled tag. ,

Species: Human; Source: HEK293

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HY-P703277 KCC3 Protein, Human (HEK293, Strep, His)
KCC3 Protein, Human (HEK293, Strep, His) is the recombinant human-derived KCC3, expressed by HEK293 , with Strep, His labeled tag. ,

Species: Human; Source: HEK293

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HY-P705599 SGK2 Protein, Human (Active, sf9, GST)
The SGK2 protein is a serine/threonine protein kinase that complexly regulates multiple cellular processes, overseeing ion channels, membrane transporters, and critical aspects of cell growth, survival, and proliferation. Its effects include upregulation of key components such as Na(+) and K(+) channels, amino acid and glutamate transporters, receptors, Na(+)/H(+) exchangers, and Na(+)/K(+) ATPase. SGK2, Human (Active, sf9, GST) is the recombinant human-derived SGK2 protein, expressed by Sf9 insect cells, with labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins AGC SGK SGK2

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HY-P706194 TSPO Protein, Human (Cell-Free, His)
The TSPO protein was originally thought to be a peripheral benzodiazepine receptor that binds protoporphyrin IX and isoquinoline carboxamide. TSPO Protein, Human (Cell-Free, His) is the recombinant human-derived TSPO protein, expressed by E. coli Cell-free, with N-10*His labeled tag.

Species: Human; Source: E. coli Cell-free

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HY-P704335 HER2/CD340 Protein, Human (HEK293, mFc)
The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (HEK293, mFc) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293, with C-mFc labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Receptor Proteins Enzymes & Regulators EGF Superfamily ErbB2/HER2 Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Cytokine Receptors Protein Tyrosine Kinases EGFR/ErbB family

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HY-P705753 CASK Protein, Human (sf9, His-GST)
CASK protein is a Mg(2+)-independent multidomain scaffold kinase that catalyzes phosphate transfer to proteins, including NRXN1, thereby contributing to synaptic transmembrane protein anchoring and ion channel trafficking. It plays a critical role in neural development, regulation of gene expression through TBR1 interactions, and mediates connections between the extracellular matrix, multiligands, and the actin cytoskeleton. CASK, Human (sf9, His-GST) is the recombinant human-derived CASK protein, expressed by sf9 insect cells, with N-Avi labeled tag.

Species: Human; Source: sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) CAMK CASK

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HY-P706100 SGK Protein, Human (Active, S422D, sf9, His-GST)
SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK, Human (Active, S422D, sf9, His-GST) is the recombinant human-derived SGK protein, expressed by Sf9 insect cells, with N-6*His;N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) AGC SGK SGK1/SGK

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HY-P706101 SGK2 Protein, Human (Active, S356D, sf9, His-GST)
The SGK2 protein is a serine/threonine protein kinase that complexly regulates multiple cellular processes, overseeing ion channels, membrane transporters, and critical aspects of cell growth, survival, and proliferation. Its effects include upregulation of key components such as Na(+) and K(+) channels, amino acid and glutamate transporters, receptors, Na(+)/H(+) exchangers, and Na(+)/K(+) ATPase. SGK2, Human (Active, S356D, sf9, His-GST) is the recombinant human-derived SGK2 protein, expressed by Sf9 insect cells, with N-6*His;N-GST labeled tag.

Species: Human; Source: Sf9 insect cells

Enzymes & Regulators Kinases Transferases (EC 2) AGC SGK SGK2

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HY-P82796 Cyclooxygenase 2 Antibody (YA2541)
Cyclooxygenase 2 Antibody (YA2541) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclooxygenase 2.

Host: Rabbit; Reactivity: Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P80143 Glucocorticoid Receptor alpha Antibody (YA754)
Glucocorticoid Receptor alpha Antibody (YA754) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucocorticoid Receptor alpha.

Host: Mouse; Reactivity: Human, Mouse

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P80687 Glucocorticoid Receptor Antibody (YA412)
Glucocorticoid Receptor Antibody (YA412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P81780 SGK1 Antibody (YA1525)
SGK1 Antibody (YA1525) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SGK1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82175 CLOCK Antibody (YA1920)
CLOCK Antibody (YA1920) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLOCK.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P82850 Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)
Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Glucocorticoid Receptor (Ser226).

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P82040 PBR Antibody (YA1785)
PBR Antibody (YA1785) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PBR.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86778 ATP5F1 Antibody (YA6471)
ATP5F1 Antibody (YA6471) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP5F1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P810934 TGF beta 2 Antibody
TGF beta 2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TGF beta 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P811220 TGF beta 2/ TGFB2 Antibody
TGF beta 2/ TGFB2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TGF beta 2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P810816 TGF beta 2 Antibody (YA10059)
TGF beta 2 Antibody (YA10059) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to TGF beta 2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P810925 Nav1.7 Antibody
Nav1.7 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Nav1.7.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P80687A Glucocorticoid Receptor Antibody (YA412)(PBS only)
Glucocorticoid Receptor Antibody (YA412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P811175 Phospho-GRLF1 (Tyr1105) Antibody
Phospho-GRLF1 (Tyr1105) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-GRLF1 (Tyr1105).

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P82040A PBR Antibody (YA1785)(PBS only)
PBR Antibody (YA1785) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PBR.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82459 TIMELESS Antibody (YA2204)
TIMELESS Antibody (YA2204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TIMELESS.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P82459A TIMELESS Antibody (YA2204)(PBS only)
TIMELESS Antibody (YA2204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TIMELESS.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P85104 CLOCK Antibody (YA4796)
CLOCK Antibody (YA4796) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CLOCK.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P85607 BAG1 Antibody (YA5299)
BAG1 Antibody (YA5299) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BAG1.

Host: Mouse; Reactivity: Human, Mouse

Monoclonal Antibodies Primary Antibodies

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HY-P86697 GPR84 Antibody (YA6389)
GPR84 Antibody (YA6389) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPR84.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86719 C-erbB-2/HER2 Antibody (YA6411)
C-erbB-2/HER2 Antibody (YA6411) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to C-erbB-2/HER2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P86719A C-erbB-2/HER2 Antibody (YA6411)(PBS only)
C-erbB-2/HER2 Antibody (YA6411) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to C-erbB-2/HER2.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P87004 PBR Antibody (YA6697)
PBR Antibody (YA6697) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PBR.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87329 PER3 Antibody (YA7012)
PER3 Antibody (YA7012) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PER3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P87329A PER3 Antibody (YA7012)(PBS only)
PER3 Antibody (YA7012) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PER3.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Primary Antibodies

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HY-P811125 GAS3 Antibody
GAS3 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GAS3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

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HY-P82850A Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)(PBS only)
Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Glucocorticoid Receptor (Ser226).

Host: Rabbit; Reactivity: Human, Rat

Monoclonal Antibodies Recombinant Antibodies Modification Specific Antibodies Primary Antibodies

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HY-P85192 Glucocorticoid Receptor Antibody (YA4884)
Glucocorticoid Receptor Antibody (YA4884) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Mouse; Reactivity: Human

Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies

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HY-P86539 Glucocorticoid Receptor Antibody (YA6231)
Glucocorticoid Receptor Antibody (YA6231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86799 CASK Antibody (YA6492)
CASK Antibody (YA6492) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CASK.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-P86916 FOXP3 Antibody(YA6609)
FOXP3 Antibody(YA6609) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXP3.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

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HY-K0305 Human CD34+ Cells Negative Selection Kit

MCE Human CD34+ Cells Negative Selection Kit is designed for the isolation of CD34+ cells from human cord blood mononuclear cells (CBMC) or human peripheral blood mononuclear cells (PBMC).

Cell Biology Cell Isolation

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HY-K0356 Human CD3 Cell Depletion Magnetic Beads (Positive Selection)

MCE Human CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-human CD3 antibodies, enabling the specific binding and magnetic removal of CD3+ cells from single-cell suspensions derived from human peripheral blood mononuclear cells (PBMCs) or human peripheral blood leukocytes (WBCs). This allows efficient enrichment of the non-CD3+ cell population.

Cell Biology Cell Isolation

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HY-K0358 Human CD66b+ Cell Positive Selection Kit

MCE Human CD66b+ Cell Positive Selection Kit is designed for the efficient isolation of CD66b+ cells from human peripheral blood single-cell suspensions. CD66b+ cells are first specifically labeled with the CD66b Capture Antibody and subsequently captured using Releasable Magnetic Beads. Following magnetic separation, the beads are detached from the cell surface using Magnetic Beads Release Buffer, resulting in highly purified CD66b+ cells free of residual magnetic bead labeling.

Cell Biology Cell Isolation

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HY-K0359 Human Neutrophil Negative Selection Kit

MCE Human Neutrophil Negative Selection Kit can isolate neutrophils from fresh peripheral blood. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells, followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of human neutrophils.

Cell Biology Cell Isolation

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Keywords

cortisol circadian rhythm | cortisol ultradian rhythm | hypothalamic-pituitary-adrenal axis | HPA axis | glucocorticoid signaling | glucocorticoid receptor | circadian clock | CLOCK-BMAL1 | cortisol pulsatility | peripheral clocks | chronotherapy | cortisol dysregulation | metabolic disease | inflammation | neuropsychiatric disease | glioblastoma | glucocorticoid replacement therapy